МЕДИЦИНСКОЕ УСТРОЙСТВО ДЛЯ ЧРЕСКОЖНОГО ВВЕДЕНИЯ ВВОДИМОГО ЭЛЕМЕНТА В ТКАНЬ ОРГАНИЗМА

БИОПСИЙНАЯ ИГЛА С БОЛЬШИМ МЕЖВОЛОКОННЫМ РАССТОЯНИЕМ НА НАКОНЕЧНИКЕ

... 1. Биопсийное устройство, содержащее:стержень (10) и трубчатый элемент (50), при этом стержень размещается с возможностью перемещения внутри трубчатого элемента,причем стержень имеет продольную ось (14) и дистальный конец (12), причем на дистальном конце стержня сформирован скос (30), причем скос обращен вверх,причем, по меньшей мере, два канала сформированы внутри стержня (10) в продольном направлении стержня, причем каждый канал формирует отверстие в скошенной поверхности, причем оптическое волокно (40) размещается внутри каждого из каналов, ипричем углубление (20) сформировано в стержне рядом с дистальным концом стержня;характеризующееся тем, что углубление обращено в боковом направлении; причем, направление вверх и боковое направление являются направлениями, которые взаимно смещены в окружном направлении вокруг продольной оси (14) стержня.2. Биопсийное устройство по п. 1, в котором расстояние (45) между двумя отверстиями в скошенной поверхности больше, чем диаметр стержня.3. Биопсийное ...

DEVICES FOR THE LOCALIZATION OF LESIONS IN FIRM FABRIC

PROBE FOR THE DIELECTRIC AND OPTICAL DIAGNOSTICS

FIBER OPTICS FOR SCANNING ANALYTEN AND MANUFACTURING PROCESSES FOR IT

SAND YIELDING SENSOR FOR THE DETERMINATION OF A ANALYTKONZENTRATION

ELECTRODE ARRANGEMENT AND MEASURING DEVICE FOR THE MEASUREMENT OF THE ELECTRICAL ACTIVITY IN AN ELECTRICALLY ACTIVE FABRIC

INTEGRATED LANZETTE AND TESTSTREIFEN FOR ANALYTIC MEASUREMENT

PROCEDURE AND PROBE FOR THE DETERMINATION OF THE DISCHARGE POSITION OF VENTRICULAEREN TACHYCARDIAS.

LIQUID DELIVERY DEVICE REGULARLY BY A ANALYTEN AND A MONITORING OF THE ANALYTEN

CATHETER FOR THE IMAGING OF MEANS OF ACOUSTIC ENERGY

REAL TIME SELF-ADJUSTING CALIBRATION ALGORITHM

A multipolar transmural probe

Wireless nerve integrity monitoring systems and devices

A nerve integrity monitoring device includes a control module and a physical layer module. The control module is configured to generate a payload request. The payload request (i) requests a data payload from a sensor in a wireless nerve integrity monitoring network, and (ii) indicates whether a stimulation probe device is to generate a stimulation pulse. The physical layer module is configured to (i) wirelessly transmit the payload request to the sensor and the stimulation probe device, or (ii) transmit the payload request to a console interface module. The physical layer module is also configured to, in response to the payload request, (i) receive the data payload from the sensor, and (ii) receive stimulation pulse information from the stimulation probe device. The data payload includes data corresponding to an evoked response of a patient. The evoked response is generated based on the stimulation pulse.

Methods of measuring the concentration of an analyte in a subject

APPARATUS AND METHOD FOR DETERMINING VISCOSITY OF THE BLOOD OF A LIVING BEING

CLOSED LOOP/SEMI-CLOSED LOOP THERAPY MODIFICATION SYSTEM

A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to compare the measured blood glucose value to a target blood glucose value and adjust a therapy delivery parameter if the measured blood glucose value is not consistent with the target blood glucose value, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter.

SYSTEM AND METHOD FOR DETERMINING THE POINT OF HYDRATION AND PROPER TIME TO APPLY POTENTIAL TO A GLUCOSE SENSOR

According to an embodiment of the invention, a method of determining hydration of a sensor having a plurality of electrodes is disclosed. In particular embodiments, the method couples a sensor electronics device to the sensor and measures the open circuit potential between at least two of the plurality of electrodes. Then, the open circuit potential measurement is compared to a predetermined value. In some embodiments, the plurality of electrodes includes a working electrode, a reference electrode, and a counter electrode. In still further embodiments, the open circuit potential between the working electrode and the reference electrode is measured. In other embodiments, the open circuit potential between the working electrode and the counter electrode is measured. In still other embodiments, the open circuit potential between the counter electrode and the reference electrode is measured.

ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM

Glucose sensor for implantation within a mammal, the analyte sensor comprising a flexible substrate, a conductive layer disposed on the substrate and comprising a reference electrode, a working electrode and a counter electrode. The sensor further comprises an analyte sensing layer, an analyte modulating layer and a cover layer disposed on the analyte sensor apparatus, wherein the cover layer comprises an aperture positioned on the cover layer so as to facilitate an analyte present in the mammal contacting and diffusing through the analyte modulating layer and contacting the analyte sensing layer. The device further comprises a processor for noise reduction and data processing A fuse element for avoiding overuse, circuitry for generating a pulsed sensing current and means for sensing if the sensor is sufficiently hydrated. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM

Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes, comprising : a plurality of sensor wires (301, 302, 303, 304) having a first end and second end and each arranged in a substanially common orientation, the plurality of sensor wires being electically conductive and including: a first sensor wire (303, 304) substantially covered by a first electically insulating cover (310), wherein a aperture in the first electrically insulating cover defines a working electrode area (313, 314); a second sensor wire (301) substantially covered by a second electrically insulating cover (310), wherein an aperture in the second electrically insulating cover defines a reference electrode area (311); and a third sensor wire (302) substantially covered by a third electrically insulating insulating cover ...

DEVICES AND METHODS FOR PERCUTANEOUS INTRATUMORAL THERAPY DELIVERY

Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.

ELECTRODE FABRICATION AND DESIGN

Disclosed are biocompatible multi-electrode devices capable of being implanted in sensitive tissue, such as the brain, and methods for fabricating such arrays. The disclosed arrays can be implanted in living biological tissue with a single needle insertion. The devices can include linear arrays with contacts along an edge, linear arrays with multiple electrodes per opening in a parylene support layer, multi-thread electrode arrays, tree-like electrode arrays, and combinations thereof. In an embodiment, a compliant electrode apparatus can comprise a biocompatible and bio-implantable compliant dielectric having a top edge defined by a top and a side along a length of the dielectric, insulated electrical traces oriented along the length of the dielectric, and electrode contacts coupled to the traces and situated on the side along the length of the dielectric, wherein an exposed portion of a respective electrode contact protrudes beyond the top edge of the dielectric.

SENSING SYSTEM FOR PERICARDIAL ACCESS

A surgical instrument includes an impedance sensing system for monitoring the position of the tip of the surgical instrument relative to the pericardial space. The surgical instrument consists of a guidewire or needle including a conductive core terminating at a distal tip of the guidewire or needle. The distal tip has a conductive surface exposed to patient tissues and/or fluids. The impedance sensing system includes a first electrode formed by the exposed surface of the guidewire or needle, and at least a second electrode isolated from the conductive core of the guidewire or needle. The second electrode may be formed on an outer surface of the guidewire or needle, or may be a pad electrode applied to the patient skin. The impedance sensing system also includes an impedance analyzer for measuring impedance and phase using one or more frequencies.

INTEGRATED LANCE AND STRIP FOR ANALYTE MEASUREMENT

The present invention relates, in general, to lancing elements for use in drawing bodily fluids out of a patient and, more particularly, to an improved lancing element including first and second elements positioned relative to each other such that an incision formed by the first element is held open by the second element and bodily fluids are pulled up the lancing element by surface tension on the first and second lancing elements.

SYSTEM AND METHOD FOR OPTICAL CONTINUOUS DETECTION OF AN ANALYTE IN BLOODSTREAM

A method for performing a blood assay includes the steps of positioning an optical biosensor in fluid communication with a blood vessel whereby bloo d from the blood vessel contacts the biosensor. The biosensor includes at least one material adapted to bind to an analyte. The method also includes the steps of detecting a change in at least one optical property of the biosensor resulting from binding of the at least one material with the analyte and transmitting a continuous signal representative of the change in at least one optical property of the biosensor to a display module to provide real time analysis by a clinician.

NEEDLE HUB FOR OVER-THE-NEEDLE CATHETER

The present disclosure is directed to an over-the-needle (OTN) catheter assembly having an improved needle hub. The OTN catheter assembly includes a catheter defining a lumen extending from a proximal end to a distal end. A needle having a proximal end and a distal end is configured within the lumen of the catheter. The needle hub is configured with the proximal end of the needle and includes a bore defined therethrough. The needle hub also includes at least one cavity extending from the bore to an exterior surface of the needle hub. Thus, the needle extends at least partially through the bore of the needle hub such that the needle is exposed via the cavity from the exterior surface of the needle hub so as to engage a nerve stimulator apparatus.

CANNULA INSERTION DETECTION

Sensors are disclosed that detect whether a cannula is properly inserted to its full depth in a subject's skin. The sensors may be used with a blood glucose monitor, or with a continuous insulin infusion pump, infusion set, or other system involving intermittent or continuous testing and/or drug delivery.

APPARATUS AND METHOD FOR DETECTING AN ABDOMINAL ELECTROPHYSIOLOGICAL SIGNAL

The invention concerns a multi-electrode patch for abdominal electrophysiological detection. The patch has a flexible substrate interconnecting multiple electrodes and a module unit for removably engaging with an electronic readout device for detecting a maternal and/or fetal electrophysiological signal from the electrodes. The module has a mechanical module unit for removable mechanical engagement with a housing of the readout device, and an electrical module unit for making an electrical connection from the electrodes to the readout device. Engaging the patch with the readout device comprises engaging both the mechanical module unit and the electrical module unit. The patch may be flexible in a manner that allows variation in the relative positioning between the electrodes. The patch and/or electronic readout device may comprise a security device for communication of an authentication code.

WIRELESS NERVE INTEGRITY MONITORING SYSTEMS AND DEVICES

A nerve integrity monitoring device includes a control module and a physical layer module. The control module is configured to generate a payload request. The payload request (i) requests a data payload from a sensor in a wireless nerve integrity monitoring network, and (ii) indicates whether a stimulation probe device is to generate a stimulation pulse. The physical layer module is configured to (i) wirelessly transmit the payload request to the sensor and the stimulation probe device, or (ii) transmit the payload request to a console interface module. The physical layer module is also configured to, in response to the payload request, (i) receive the data payload from the sensor, and (ii) receive stimulation pulse information from the stimulation probe device. The data payload includes data corresponding to an evoked response of a patient. The evoked response is generated based on the stimulation pulse.

ACCESS NEEDLE PRESSURE SENSOR DEVICE AND METHOD OF USE

A tool and method of positioning and delivering medical devices and thera peutics within the pericardial space, as well as other body part or space. A needle is inserted into the chest through a sub-xiphoid puncture, and the p ressure within the needle is monitored manometrically or otherwise sensed as the needle is advanced towards the pericardial space. By reading the pressu re within the needle while it is advanced, the clinician is able to know tha t he or she is avoiding insertion of it into organs or spaces not intended t o be the target location. In addition the retractable sharp edge allows the operator to access the space and cut tissue but do so safely by retracting t he sharp edge.

DEVICE AND METHOD FOR POSITIONING A CANNULA FOR A NERVE BLOCK

An apparatus for positioning a cannula or a catheter for nerve block, comprising a stimulation unit (20) for generating electrical signals, comprising a unipolar cannula (10), which is electrically insulated at its circumference over its axial length and has an electrically conducting, exposed stimulation electrode (12) at its distal end, and comprising a skin electrode (14), which can be applied with electrically conducting contact to the surface (26) of the body of a patient, wherein the stimulation electrode (12) and the skin electrode (14) can be connected to the stimulation unit (20) such that the electrical signals are made to pass from the stimulation electrode (12) through the body (28) of the patient to the skin electrode (14), wherein the stimulation unit (20) has a measuring device (22) for measuring the electrical resistance between the stimulation electrode (12) and the skin electrode (14) and wherein the stimulation unit (20) has an alarm device (24), which generates a perceptible ...

INTEGRATED OPTICAL NEURAL PROBE

In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.

SUB-EPIDERMAL ELECTRIC WARNING DEVICE

A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention.

BIOPSY DEVICE WITH INTEGRATED OPTICAL SPECTROSCOPY GUIDANCE

An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures.

MEASURING THE CONCENTRATION OF A SUBSTANCE

A system for measuring the concentration of an assay substance comprising a sensor having an optical fibre (10) on one end of which is coated a body (22). A fluorophor is dispersed within the body (22), the fluorescent activity of which is altered in relationship to the concentration of the assay substance. Light from a source such as an LED (40) is carried by the fibre (10) to the body (22). Light emitted by the fluorophor is carried to a detector unit (54) along the fibre (10). Concentration of the assay substance is determined by measurement of the characteristics of the growth in emitted light following activation of the LED (40).

Zelle für polarographische Analysen

ENDOSCOPE-TYPE DEVICE PARTICULARLY FOR MEDICAL USE.

SYSTEM FOR MONITORING BODY BY ELECTROPHORESIS

Body tissue impedance measuring electrode - has surface of stainless steel contact tip sanded to increase surface area

Physiological signal monitoring device and sensor holder thereof

The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting therethrough the sensor and containing a part of the sensor, and a containing indentation containing the signal output end, wherein the containing indentation has a surrounding wall kept apart from the signal output end to define a space.

METHODS AND INSTRUMENTS FOR ASSESSING BONE FRACTURE RISK

Methods and instruments for assessing bone, for example fracture risk, in a subject in which a test probe is inserted through the skin of the subject so that the test probe contacts the subject's bone and the resistance of the test bone to microscopic fracture by the test probe is determined. Macroscopic bone fracture risk is assessed by measuring the resistance of the bone to microscopic fractures caused by the test probe. The microscopic fractures are so small that they pose negligible health risks. The instrument may also be useful in characterizing other materials, especially if it is necessary to penetrate a layer to get to the material to be characterized.

DEVICE FOR MEASURING URINARY DETRUSOR PRESSURE

The present invention relates to a device for measuring bladder pressure, comprising: a measurement rod inserted into the abdomen of a user to measure both abdomen pressure and bladder pressure; and a body unit provided to be worn on the waist of the user and electrically connected to the measurement rod so as to calculate and store urinary detrusor pressure measured by subtracting a measurement abdomen pressure from a measurement bladder pressure measured by the measurement rod.

APPARATUS AND METHOD FOR POSITIONING A CANNULA FOR NERVE BLOCK

An apparatus for positioning a cannula or a catheter for nerve block, comprising a stimulation unit (20) for generating electrical signals, comprising a unipolar cannula (10), which is electrically insulated at its circumference over its axial length and has an electrically conducting, exposed stimulation electrode (12) at its distal end, and comprising a skin electrode (14), which can be applied with electrically conducting contact to the surface (26) of the body of a patient, wherein the stimulation electrode (12) and the skin electrode (14) can be connected to the stimulation unit (20) such that the electrical signals are made to pass from the stimulation electrode (12) through the body (28) of the patient to the skin electrode (14), wherein the stimulation unit (20) has a measuring device (22) for measuring the electrical resistance between the stimulation electrode (12) and the skin electrode (14) and wherein the stimulation unit (20) has an alarm device (24), which generates a perceptible ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. The system can include an applicator 12, a mounting unit 14, and an electronics unit 16.

DEVICE FOR BLOOD TEMPERATURE MEASUREMENT IN-VIVO

A device for the measurement of the temperature of blood in-vivo which includes a penetrator configured for the penetration of a blood vessel and a temperature sensor residing on the penetrator.

BIOPSY GUIDANCE BY ELECTROMAGNETIC TRACKING AND PHOTONIC NEEDLE

A system for providing integrated guidance for positioning a needle in a body has two levels of guidance: a coarse guidance and a fine guidance. The system comprises a non-invasive tracking system for tracing the biopsy device in the body, for providing the coarse guidance. Furthermore, the system comprises an optical detector mounted on the needle for obtaining optical information discriminating tissue in the body, for providing the fine guidance.

TRANSCUTANEOUS ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. In a preferred embodiment, a transcutaneous analyte sensor system 10 is provided including an applicator 12, a mounting unit 14, and an electronics unit 16. The mounting unit 14 includes a base 24 adapted for mounting on the skin of a host and one or more contacts 28 configured to provide secure electrical contact between the sensor and the electronics unit 16. The applicator 12 includes an applicator body 18 that guides the applicator components and an applicator body base 60 configured to mate with the mounting unit 14 during insertion of the sensor into the host. One or more release latches 30 enable release of the applicator body base 60.

SENSOR WITH LAYERED ELECTRODES

A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

SUB-EPIDERMAL ELECTRIC WARNING DEVICE

A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention.

FLUORESCENCE SENSOR

This fluorescence sensor (4) is equipped with: an indicator (17) for producing a fluorescence corresponding to an analyte quantity when excitation light is received; a PD element (12) for converting the fluorescence to an electrical signal; an LED (15) for producing the excitation light, the indicator (17) being disposed on an upper surface side and side surface side thereof; a filter (14) for blocking the excitation light, the filter (14) covering the PD element (12); and a light-blocking layer (18) by which outside light is blocked from entering the indicator (17) but through which the analyte passes.

BLOOD WITHDRAWAL CANNULA OF A PUMP REPLACING OR ASSISTING ACTIVITY OF THE HEART

The invention relates to a blood withdrawal cannula (4) for connecting a pump (2) assisting or replacing activity of the heart to the inner volume of a heart ventricle (1), in particular the left ventricle. At the end thereof that is located in the ventricle the cannula has a pressure sensor (7a, 7b) for measuring the ventricle pressure and/or ventricle pressure differences and at the same end of the cannula has a volume sensor (3a, 3b, 5, 6) for measuring the volume and/or volume changes of the ventricle (1) in at least a partial region of the ventricle. The invention further relates to a measuring device for monitoring the ventricle contractions and/or the function of a pump replacing or assisting activity of the heart. The measuring device can be/is connected to the pressure sensor (7a, 7b) and to the volume sensor of a blood withdrawal cannula according to any one of the preceding claims and is designed to detect pressure changes and volume changes of a ventricle (1) as the heart is ...

COMBINED DRUG DELIVERY AND ANALYTE SENSOR APPARATUS

Embodiments of the present invention provide methods and apparatuses for analyte sensing combined with drug delivery in an integrated system. In an embodiment, a device may be utilized to sense an analyte, and in response to a measurement obtained therefrom, introduce a controlled amount of a drug to a user as a corrective action.

METHOD AND APPARATUS FOR MEASURING CONCENTRATION OF SUBSTANCE IN LIVING BODY

A fluorescence indicator (P) in a container (11) is injected into a measurement subject living body (S) through an inlet port (11A) for combination with a substance in the measurement subject living body (S). Then, excitation light (L) is emitted from excitation light sources (12) to irradiate the measurement subject living body (S) therewith. Then, the reflected light (R) obtained is multiple-reflected by a reflection film (14) disposed on the side wall of the container (11) and is introduced into a detecting section (13). Then, fluorescence response based on combination between the substance in the living body and the fluorescence indicator (P) included by the reflected light (R) is detected by the detecting section (13) disposed in the direction of injection of the fluorescence indicator (P).

METHOD AND/OR SYSTEM FOR SENSOR ARTIFACT FILTERING

Disclosed are a method and/or system for filtering sensor measurements. In one particular implementation, a sensor signal may be processed concurrently in a plurality of signal-filter paths. A particular signal-filter path may be selected to provide an output signal for obtaining a measurement based, at least in part, on a measurement of noise associated with the sensor signal.

MEDICO-TECHNICAL PROCESS AND MEANS FOR MEASURING BLOOD IRRIGATION OF ORGANS

A measurement device relates to a patient (500) connected by a coded mask (501) to a hydrogen container (502). A perfusion container (503) is connected by corresponding connecting elements to a perfusion needle (504). Measurement probes (506), as well as a surgical instrument (507), are also connected to the measurement device (507) by connecting elements provided with corresponding fittings. Implanted probes (505) are provided with an electromagnetically readable code. Similarly, all used utensils and instruments are provided with a code (510).

Particle-containing membrane and particulate electrode for analyte sensors

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

ENDOSCOPIC DEVICE INTENDED, IN PARTICULAR, FOR A MEDICAL USAGE

An endoscopic device includes an optical guide head configured to be at least partially inserted into a body or a cavity in order to view or image an object or a site that is poorly accessible to the naked eye. The optical guide head of such an endoscopic device is formed from an optical rod with a refractive index gradient.

TRANSCUTANEOUS ANALYTE SENSOR

Abstract of the Disclosure The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Noninvasive system for characterizing tissue in vivo

A tool for nondestructive interrogation of the tissue including a light source emitter and detector which may be mounted directly on the surgical tool in a tissue contacting surface for interrogation or mounted remotely and guided to the surgical field with fiber optic cables. The light source may be broadband and wavelength differentiation can be accomplished at the detector via filters or gratings, or using time, frequency, or space resolved methods. Alternatively, n discrete monochromatic light sources may be provided which are subsequently multiplexed into a single detector by time or by frequency multiplexing. The optical sensing elements can be built into a surgical tool end effector tip such as a tissue grasping tool which has cooperating jaws (bivalve or multi-element). In the preferred embodiment the light source (or the fiber optic guide) is mounted on one jaw and the detector (or fiber optic guide) is mounted in the opposing jaw so that the light emitter and detector are facing ...

Fetal probe apparatus

Disclosed is a fetal probe that is insertable through the mother's vagina and cervixes and connectable to a pulse oximeter for monitoring the EKG and oxygen saturation of hemoglobin of a fetus during labor and delivery. The probe incorporates at least one spiral electrode and optical fiber or fibers and/or solid state light sources for monitoring oxygen saturation. Light emitting diodes, or an optical fiber or fiber pair, transmit light of two different wavelengths through the fetal skin to perfused fetal tissue while either the EKG needle or another needle extends into fetal tissue and contains a light collecting optical fiber having a distal light collecting surface adjacent the relative needle distal end for collecting transmitted light that has passed through perfused fetal tissue that is interior of the fetal skin.

METHOD AND AZIMUTHAL PROBE FOR LOCALIZING THE EMERGENCE POINT OF VENTRICULAR TACHYCARDIAS

PCT No. PCT/FR88/00525 Sec. 371 Date Aug. 28, 1989 Sec. 102(e) Date Aug. 28, 1989 PCT Filed Oct. 27, 1988 PCT Pub. No. WO89/03657 PCT Pub. Date May 5, 1989.Device permitting localization of the emergence point of ventricular tachycardias in cardiological medicine, characterized, in comparison with traditional cardiac mapping, by: a precision of the same order, its speed of use, its low cost and the further possibility of localizing the macro-re-entry pathway (around aneurysms, for example). In distinction to traditional mapping, this device dispenses with the construction of a map of isochrones (14). The principle of the device according to the invention is based on localization of the propagation of the myocardial cell depolarization, or of the muscle contraction of the heart (15) which results directly therefrom. This localization is carried out in stages (17) over the length of its pathway (13) from an arbitrary point (16) on the heart chosen by the operator, retracing this pathway as ...

Analyte sensor

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Method of mapping a nerve

A method of modeling a nerve disposed within an intracorporeal treatment area of a patient includes locating an electrode at a plurality of locations within a virtual workspace and providing an electrical stimulus from the electrode to the intracorporeal treatment area. The response of a muscle to the electrical stimulus is monitored and used to determine a distance to the nerve from each of the plurality of locations. A virtual model of the nerve is then constructed within the virtual workspace using the determined distance to the nerve from each of the different positions, and the plurality of locations within the virtual workspace.

Method and system for providing integrated medication infusion and analyte monitoring system

Method and system for integrating infusion device and analyte monitoring system including medication infusion device such as an insulin pump and an analyte monitoring system such as a glucose monitoring system are provided.

Transcutaneous analyte sensor systems and methods

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Transcutaneous analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Splittable needle with fiber probe

A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.

Systems and devices to identify and limit nerve conduction

Methods and devices for improved precision in finding one or more nerves and then interrupting the transmission of neural signals through the target nerve. The treated nerve can be rendered incapable of transmitting neural signals for a select duration of time, where such a duration can be on a temporarily basis (e.g., hours, days or weeks) or a longer term/permanent basis (e.g., months or years). One embodiment of the apparatus includes a precise energy source system which features energy transfer elements that are capable of creating areas of nerve destruction, inhibition and ablation with precision.

Devices and monitoring systems for locating a blood vessel

Devices detect and assist in the avoidance of blood vessels during a surgical procedure, to avoid rupturing these blood vessels. Devices may be any penetration sensor device, such as a dilator sensor device, a hollow needle sensor device, or a trocar sensor device, which penetrates the skin and subcutaneous layers to reach a target location inside the body. The penetration sensor device includes a sensor probe which can make optical measurements to determine various parameters of the tissue at the tip of the sensor probe. These parameters may include an optical signal level returned from tissue contacting the tip of the sensor probe, an oxygen saturation level of the tissue, a total hemoglobin concentration, a blood flow, and a pulse. Based on these parameters, the presence or absence of a blood vessel at the tip of the penetration sensor device can be determined while the device travels towards the target location for surgery.

PHYSIOLOGICAL SIGNAL MONITORING DEVICE

A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of conducting springs disposed at two opposite sides of the socket. The sensing member is removably inserted into the socket. The conducting springs are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the conducting springs is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Insertion devices and methods

Devices and methods relating to analyte sensor insertion devices and methods are provided.

Transcutaneous analyte sensor systems and methods

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

SPINAL PROBE WITH TACTILE FORCE FEEDBACK AND PEDICLE BREACH PREDICTION

A system for enabling generation of photoacoustic images

The invention relates to a system (10) for enabling generation of photoacoustic images, comprising a light source (3) arranged to generate pulsed or modulated light having a wavelength in the range of 200 - 2500 nm, a biopsy needle having a needle body (4) with a distal portion (4a), the needle body being provided with an optical fiber (5) having a distal portion (5a) and adapted to conduct the light from the light source (3) via the distal portion (5a) towards a target region (2) located inside a patient (1). Photoacoustic signals (7) generated in the target region (2) are advantageously intercepted by a suitable detector, such as a per se known ultrasonic probe (6). The ultrasonic probe (6) may be connected to a data processing system (8) for visualizing suitable images (9a) on a display (9). The invention further relates to a method of generating photoacoustic images and to a biopsy needle.

SANDWICH SENSOR FOR THE DETERMINATION OF AN ANALYTE CONCENTRATION

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

A MULTIPOLAR TRANSMURAL PROBE

ANALYTE-CONTROLLED LIQUID DELIVERY DEVICE AND ANALYTE MONITOR

ELECTRODE WITH A THROTTLE FOR PREVENTING BURNS INDUCED BY HF LEAK CURRENTS

УСТРОЙСТВО ДЛЯ МОНИТОРИНГА ПОЛОЖЕНИЯ ДИСТАЛЬНОГО КОНЦА ТРУБКИ ОТНОСИТЕЛЬНО КРОВЕНОСНОГО СОСУДА

Изобретение относится к медицинской технике. Система для подачи жидкости пациенту через кровеносный сосуд содержит трубку. Трубка оборудована устройством мониторинга положения ее дистального конца относительно кровеносного сосуда для определения, занимает ли дистальный конец положение внутри кровеносного сосуда. Устройство мониторинга содержит нагревательный элемент для нагрева дистального конца, узел датчика для генерирования измерительного сигнала и узел компаратора для сравнения уровня измерительного сигнала с опорным уровнем. Измерительный сигнал является показателем тепла, переданного наружной частью дистального конца. Опорный уровень равен величине, которую достигает измерительный сигнал в ответ на минимальную скорость потока в кровеносном сосуде. Применение изобретения обеспечит отслеживание подачи жидкости в кровеносный сосуд. 14 з.п. ф-лы, 11 ил.

АППАРАТ И СПОСОБ ДЛЯ ОБНАРУЖЕНИЯ АБДОМИНАЛЬНОГО ЭЛЕКТРОФИЗИОЛОГИЧЕСКОГО СИГНАЛА

Группа изобретений относится к медицине, а именно к абдоминальному обнаружению материнских и/или фетальных электрофизиологических сигналов. Накладка с электродами содержит гибкую подложку, взаимосвязывающую электроды, и блок модуля для разъемного сопряжения с электронным считывающим устройством для обнаружения материнского и/или фетального электрофизиологического сигнала на электродах. Блок модуля содержит блок механического модуля для разъемного механического сопряжения с корпусом считывающего устройства и блок электрического модуля для создания электрического соединения электродов со считывающим устройством. Сопряжение накладки со считывающим устройством включает сопряжение как с блоком механического модуля, так и с блоком электрического модуля. Устройство безопасности накладки для предоставления электронному считывающему устройству аутентификационного кода, связанного с накладкой, предотвращает использование считывающего устройства с накладкой, которая не содержит устройство безопасности ...

КЛАССИФИКАЦИЯ ОПУХОЛЕВОЙ ТКАНИ С ИСПОЛЬЗОВАНИЕМ ПЕРСОНИФИЦИРОВАННОГО ПОРОГОВОГО ЗНАЧЕНИЯ

... 1. Система для получения, по меньшей мере, одного порогового значения для распознавания различных типов тканей, при этом система содержит:- оптический зонд (130), выполненный с возможностью получения результатов световых измерений в одном или более местах в ткани первого типа, а также- консоль (110), выполненную с возможностью спектрального анализа результатов световых измерений и определения точек данных на графике показателей многовариантного статистического анализа для формирования первого типового класса ткани на основе заданных спектральных характеристик, полученных из соответствий в результатах световых измерений, при этом консоль (110) выполнена с возможностью определения первого порогового значения для облака точек данных, принадлежащих этому первому типовому классу ткани, путем использования спектральных характеристик эталонной ткани,при этом оптический зонд (130) дополнительно выполнен с возможностью получения дополнительных результатов световых измерений в дополнительных местах ...

ИГЛА С ОПТИЧЕСКИМ ВОЛОКНОМ, ВСТРОЕННЫМ В УДЛИНЕННУЮ ВСТАВКУ

... 1. Игла, содержащая:полый стержень (100), имеющий продольную ось, и первый срез (110), образованный на участке дистального конца полого стержня и с острым первым углом (a) к продольной оси,удлиненную вставку (200), имеющую второй срез (210), образованный на участке дистального конца удлиненной вставки и с острым вторым углом (b) к продольной оси,причем первый угол (a) меньше, чем второй угол (b), иоптическое волокно (300), причем оптическое волокно расположено в удлиненной вставке (200) и оптическое волокно выступает за пределы поверхности второго среза,причем удлиненная вставка расположена и закреплена в полом стержне таким образом, что второй срез и передняя поверхность (310) волокна (300) расположены в полом стержне (100).2. Игла по п. 1, в которой передняя поверхность (310) оптического волокна (300) образована под третьим углом (c) к продольной оси, причем третий угол больше второго угла (b).3. Игла по п. 1, в которой удлиненная вставка (200) съемно закреплена в полом стержне (100).4 ...

ФОТОННАЯ СИСТЕМА ИГЛЫ С ВРЕМЕНАМИ ИНТЕГРАЦИИ ИЗМЕРЕНИЯ, ЗАВИСЯЩИМИ ОТ СКОРОСТИ СМЕЩЕНИЯ ИГЛЫ

... 1. Система (10) наведения для наведения инструмента (12, 100, 100A, 100B, 112) внутри тела (14), при этом система (10) наведения содержит:устройство (18) медицинской визуализации, выполненное с возможностью формирования изображения внутренней области тела (14),устройство (16, 102) определения типа ткани, выполненное с возможностью получения сигнала ткани из инструмента (12, 100, 100A, 100B, 112), причем устройство (16, 102) определения типа ткани выполнено с возможностью определения набора указывающих на тип ткани параметров на основании сигнала ткани из инструмента (12, 100, 100A, 100B, 112),причем система (10) наведения выполнена с возможностью определения положения инструмента (12, 100, 100A, 100B, 112) и сохранения последовательности положений,причем система (10) наведения выполнена с возможностью создания отображаемого изображения, сочетающего в себе изображение внутренней области тела и набор указывающих на тип ткани параметров, отображаемых в записанных положениях инструмента (12 ...

Vorrichtung zur in vivo Messung einer elektrophysiologischen Größe

Um eine Vorrichtung (2, 6, 7) zur verbesserten, weniger fehleranfälligen in vivo Messung einer elektrophysiologischen Größe eines Organs (1), insbesondere Herz, Hirn und/oder periphere Nerven, umfassend eine Messsonde (2) mit einem proximalen Messabschnitt (5) zum Kontaktieren des Organs (1), anzugeben, wird vorgeschlagen, dass die elektrophysiologische Größe ein von dem Organ (1) ausgehendes induktiv-magnetisches Feld ist, wobei die Messsonde (2) zum Messen eines Magnetfeldes ausgestaltet ist.

MESSUNG VON ENZYMKATALISIERTEN REAKTIONEN.

An apparatus and method for detecting displacement of a cannula

Cannula with proximally mounted camera

A minimally invasive monitoring system

Improvements in or relating to the measuring of electrochemical values

... 1,009,373. pH electrode assembly. HONEYWELL Inc. April 9,1962 [April 10, 1961], No. 13595/62. Heading G1N [Also in Division A5] A pH measuring instrument, for measuring pH values in situ and in vivo in a biological substance, comprises a pH electrode pair disposed entirely within a hollow needle to contact the substance when the needle in inserted therein. For measuring blood pH, hypodermic needle 2, on syringe barrel 3, has an end opening 9 and a cutaway portion forming a window 8. Glass electrode 14 and reference electrode 15 are surrounded by insulating material (silicone rubber) 24, 25 except in the region of window 8. Glass electrode 14 comprises a spiral ribbon member 17 immersed in HC1 and contained in a pH sensitive glass tube 16. Reference electrode 15 comprises a flat member 26 immersed in Kc1 in agar contained in a glass tube 27 having a small hole 32 at the end extending beyond material 24 into opening 9. The electrodes each consist of platinum coated with silver superficially ...

Apparatus and method for detecting an abdominal electrophysiological signal

INSERTION OF SENSORS INTO SOFT TISSUE

A sensor device, for positioning in soft tissue in the human or animal body, comprises a tubular member 1 containing at least one sensor, the tubular member having a distal end 7 supporting an apertured member 30. The apertured member 30 is connected to a surgical needle 25 by passing a suture (24) through the aperture of the apertured member 30 and the eye of the needle (25). The sensor device is positioned by passing the needle 25 through the soft tissue and drawing the suture 24 though the soft tissue to pull the tubular member 1 into the soft tissue. The needle 25 is disconnected from the sensor device by cutting the suture 24 or removing the apertured member 30. By pulling the sensor device into position, the sensor device follows the track of the needle and suture. This reduces tissue damage and also reduces the risk of damaging the sensor device as it is positioned.

PH SENSOR

A pH sensor comprises a reference electrode 4,5,6 and a sensing electrode 1,2, the sensing electrode comprising an electronically conducting matrix incorporating an anion of a weak acid. The anion may be acetate or lactate and the matrix is preferably an electronically conducting polymer such as polypyrrole, polyindole or an oxidation polymer of a heterocyclic compound such as thiophene, indole or furan. The reference electrode may be silver/silver chloride, a metal/metal ion electrode on a redox polymer such as poly(vinyl ferrocene). As shown, a disposable pH sensor for measuring foetal scalp blood comprises a hollow surgical needle 1 bearing a polypyrrole acetate film 2, plugged with agar 3 buffered to the pH of blood. The agar 3 forms a reference solution in contact with a silver/silver chloride reference electrode 6. The pH of the blood causes the polypyrrole backbone 2 to withdraw/release electrons to the needle 1. The potential between 1 and 4 indicates the pH. ...

Cannula with proximally mounted camera

ANALYSIS DEVICE TO IN-VIVO-ANALYSIS IN THE BODY OF A PATIENT

OPTICAL LOCALIZATION FIBER

Insertion system

An insertion system for inserting a sensor into fatty tissue, comprising an insertion device and an insertion needle containing a sensor, wherein the insertion device comprises a holder for the insertion needle, and a piercing mechanism so as to move the holder, with the needle held by the same, in a feed direction for a puncture. The piercing mechanism changes the feed direction during the puncture so that, at the end of the puncture, an insertion needle held by the holder is oriented obliquely or perpendicular to the initial feed direction. Also provided are methods for controlling a needle moved by an insertion device.

Re-calibration of pre-recorded images during interventions using a needle device

Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.

Lancet integrated test element tape dispenser

A lancet integrated test element tape includes a plurality of lancet integrated test elements. The lancet integrated test elements each include a lancet configured to form an incision in tissue and a test element configured to analyze body fluid from the incision in the tissue. A cartridge includes a supply compartment configured to store an unused section of the tape. The tape is folded within the supply compartment to limit damage to the lancet integrated test elements. The cartridge can further include a waste compartment in which a used section of the tape is stored. An indexing mechanism moves the tape between the supply and waste compartments.

Optical probe with feedback correction

The present invention relates to an optical probe ( 1 ) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system ( 9, 10 ) comprising drive coils ( 9 ) capable of displacing the distal end ( 3 ) of an optical guide ( 2 ) housed ( 4 ) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Systems and methods for determining location of an access needle in a subject

Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

Systems and methods for replacing signal artifacts in a glucose sensor data stream

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

Expandable catheter system for fluid injection into and deep to the wall of a blood vessel

A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

Optical sensing systems and methods

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

INTERVENTIONAL PHOTOACOUSTIC IMAGING SYSTEM

An interventional photoacoustic imaging system and method for cancer treatment comprises an optical source for applying laser energy to optically excite a treatment area, a needle, ablation tool or catheter for inserting the optical source into a body of a patient adjacent the treatment area, and an ultrasonic transducer for detecting the acoustic waves. A processor receives the raw data from the ultrasound system and processes it to thereby form a photoacoustic image of the tissue in real time. As such, image formation may be performed preoperatively, intraoperatively, and postoperatively. 1. An interventional photoacoustic imaging system for cancer treatment , comprising:an energy source including an optical source for applying laser energy to optically excite a treatment area;means for inserting the optical source into a body of a patient adjacent the treatment area;an ultrasonic transducer for detecting the acoustic waves; anda processor for analyzing the acoustic waves to thereby form a photoacoustic image of the tissue in real time.2. The interventional photoacoustic imaging system of claim 1 , wherein said inserting means is a needle and said optical source is an optical fiber coupled within a shaft of the needle claim 1 , said optical source operatively connected to a pulsed laser source.3. The interventional photoacoustic imaging system of claim 1 , wherein said inserting means is a brachytherapy needle claim 1 , a biopsy needle or an ablation tool.4. The interventional photoacoustic imaging system of claim 1 , wherein said inserting means is a needle and said optical source is an optical fiber disposed on an outer surface of a shaft of the needle claim 1 , said optical source operatively connected to a pulsed laser source.5. The interventional photoacoustic imaging system of claim 4 , wherein said inserting means is a brachytherapy needle claim 4 , a biopsy needle or an ablation tool.6. The interventional photoacoustic imaging system of claim 5 , wherein ...

IMPLANTABLE SENSOR DEVICE AND SYSTEM

The implantable medical device for measuring pressure is disclosed. The implantable medical device is connectable to a medical lead and comprises an outer sheath and a helically shaped needle arranged at the outer sheath. A pressure sensing body having a distal part is movably arranged in the outer sheath. The pressure sensing body is arranged such that the distal part is located within the outer sheath in an initial state of the pressure sensing body, wherein the pressure sensing body is arranged to be advanced from the initial state to protrude from the outer sheath and such that it is at least partially surrounded by the helically shaped needle; and a pressure sensor arranged at or adjacent to the distal part of the pressure sensing body for sensing pressure. 115-. (canceled)16. An implantable medical device for measuring pressure connectable to a medical lead , comprising:an outer sheath;a helically shaped needle arranged at said outer sheath;a pressure sensing body having a distal part and being movably arranged in said outer sheath, said pressure sensing body being arranged such that said distal part is located within said outer sheath in an initial state of said pressure sensing body, wherein said pressure sensing body is arranged to be advanced from said initial state to protrude from said outer sheath such that it is at least partially surrounded by said helically shaped needle; anda pressure sensor arranged at or adjacent to said distal part of said pressure sensing body for sensing pressure.17. The implantable medical device according to claim 16 , wherein said helically shaped needle is fixed at said outer sheath or at a distal element fitted in a distal opening of said outer sheath.18. The implantable medical device according to claim 17 , wherein said distal element comprises a through hole arranged such that said pressure sensing body can be advanced through said through hole.19. The implantable medical device for measuring pressure connectable to a ...

BIO-DIAGNOSTIC TESTING SYSTEM AND METHODS

An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein. 1. A bio-diagnostic system comprising:a probe assembly configured for insertion into an animate object, the probe assembly comprising:an optical waveguide configured for propagating a light beam; andan optical resonator incorporating a capture agent placed upon a binding site that is exposed to a fluid, the optical resonator configured to receive at least a portion of the propagated light beam and generate therefrom, a first resonant wavelength when no binding reaction is present at the binding site, and a second resonant wavelength when a binding reaction is present at the first binding site, the binding reaction modifying a refractive index of the optical resonator.2. The bio-diagnostic system of claim 1 , wherein the probe assembly is at least one of: a) a needle comprising a first bio-sensor chip that includes the optical waveguide and the first optical resonator claim 1 , b) a catheter comprising a second bio-sensor chip that includes the optical waveguide and the first optical resonator claim 1 , or c) a third bio-sensor chip configured for insertion into the vein claim 1 , the third bio-sensor chip comprising the optical waveguide and the first optical resonator.3. The bio-diagnostic system of claim 2 , wherein at least one of the needle or the catheter is a part of an intravenous (IV) apparatus.4. The bio-diagnostic system of claim 2 , wherein the needle has a sub-mm diameter.5. The bio-diagnostic system of claim 4 , wherein the fluid is one of: blood claim 4 , lymphatic fluid claim 4 , ...

MULTIPLE MEDICAL DEVICE GUIDANCE

A system and method for providing image guidance for placement of one or more medical devices at a target location. The system receives emplacement information of medical devices within a predetermined area. The system calculates a viewing angle in a virtual 3D space of a plurality of virtual medical devices corresponding to the plurality of medical devices. The system also causes a display device to display the plurality of virtual medical devices based at least on the calculated viewing angle. 1. A method , comprisingreceiving emplacement information of a plurality of needles;receiving emplacement information of a medical imaging device;receiving at least one image from the medical imaging device;calculating a first viewing angle in a virtual 3D space of the at least one image based at least on the emplacement information of the medical imaging device with respect to a perspective view;calculating a second viewing angle in the virtual 3D space of a virtual medical imaging device corresponding to the medical imaging device based at least on the emplacement information of the medical imaging device with respect to the perspective view;calculating a plurality of viewing angles in the virtual 3D space of a plurality of virtual needles corresponding to the plurality of needles based at least on the emplacement information of the plurality of needles with respect to the perspective view;causing the display device to display the at least one image based at least on the first calculated viewing angle in the virtual 3D space;causing the display device to display the virtual medical imaging device based at least on the second calculated viewing angle in the virtual 3D space; andcausing a display device to display the plurality of virtual needles based at least on the plurality of calculated viewing angles in the virtual 3D space.2. A method , comprisingreceiving emplacement information of a plurality of medical devices within a predetermined area;calculating a viewing angle ...

THREE-DIMENSIONAL METAL-COATED NANOSTRUCTURES ON SUBSTRATE SURFACES, METHOD FOR PRODUCING SAME AND USE THEREOF

The invention relates to a method for producing column-shaped or conical nanostructures, wherein the substrate surface is covered with an arrangement of metal nanoparticles and etched, the nanoparticles acting as an etching mask and the etching parameters being set such that column structures or cone structures are created below the nanoparticles and the nanoparticles are preserved as a structural coating. 1. A method for generating on substate surfaces nanostructures with a column-like or conical shape , which have a metal coating on an upper side thereof , said method comprising the steps of:{'sub': 2', '2, 'a) providing a substrate surface coated with SiOor consisting of SiO;'}b) covering the substrate surface with an arrangement of metal nanoparticles;c) contacting the substrate surface with a metal salt solution under reducing conditions,whereby a reduction of the metal salt and currentless deposition of elemental metal on the metal nanoparticles and a corresponding enlargement of the metal nanoparticles is caused; andd) etching to a depth of 10-500 nm of the substrate surface covered with the nanoparticles obtained in step c), wherein the nanoparticles act as an etching mask and etching parameters are adjusted in such a way that column-like structures or conical structures are formed underneath the nanoparticles and the nanoparticles remain kept there as a structure coating.2. The method according to claim 1 , wherein the etching step comprises a treatment with an etchant which is selected from the group consisting of chlorine claim 1 , gaseous chlorine compounds claim 1 , fluorinated hydrocarbons claim 1 , fluorocarbons claim 1 , oxygen claim 1 , argon claim 1 , SFand mixtures thereof.3. The method according to claim 1 , wherein the etching step is performed for a period of time in a range from 10 s to 60 min.4. The method according to claim 1 , wherein the nanoparticles in step b) have a predetermined two-dimensional geometric arrangement.5. The method ...

Evoked Stapedius Reflex Threshold Tile Electrode

An electrode arrangement is described for sensing electrical activity in target tissue. An inner electrode has an elongate electrode body formed as a cylindrical section with an inner penetrating end for insertion into the stapedius muscle target tissue. An outer electrode fits over the inner electrode and an outer penetrating end for insertion into the target tissue. The two electrodes are joined together with their electrode bodies in parallel so that the penetrating ends of the electrodes penetrate in the same direction into the target tissue to sense electrical activity in the target tissue.

Device for diagnosing condition of liver and method of examining condition of liver

The diagnostic device disclosed in this application is a device for diagnosing liver condition. The diagnostic device comprises a nitric oxide sensor and an information output unit. The nitric oxide sensor can be brought into contact with hepatocytes making up the liver and detects the concentration of nitric oxide produced by the hepatocytes. The information output unit, based on the nitric oxide concentration detected by the nitric oxide sensor, outputs information for diagnosing the condition of the liver. The information output unit can, for example, output a graph showing the change over time in the nitric oxide concentration detected by the nitric oxide sensor.

BODY FLUID COMPONENT MEASURING SYSTEM

A body fluid component measuring system which is capable of continuous measurement and reduces downtime includes a sensor unit which is positionable indwelling in the skin of a subject and which measures a predetermined body fluid component included in the body fluid of the subject; and a transmission unit which is detachably attached to the sensor unit and which calculates blood glucose level based on measurement data measured by the sensor unit, and transmits the calculated blood glucose level to a display unit. Identification information for establishing communication between the transmission unit and the display unit is stored in the sensor unit, and the transmission unit, upon activation, uses the identification information read out by the sensor unit to establish communication with the display unit. 1. A body fluid component measuring system comprising:a display unit;a sensor unit attachable to a body of a subject, the sensor unit comprising: a needle possessing a point configured to be indwelled in skin of the subject when the sensor unit is attached to the body of the subject to obtain a body fluid sample of the subject; a component measuring section which is connected to the needle to receive the body fluid sample obtained by the needle and which measures a predetermined body fluid component of the body fluid sample; and a memory;a transmitting unit detachably attachable to the sensor unit, the transmitting unit comprising: memory storing a calculating program which calculates a concentration of the predetermined body fluid component included in the body fluid sample based on the predetermined body fluid component of the body fluid sample measured by the component measuring section; and a transmitting module which transmits a result of the calculation of the concentration of the predetermined body fluid component to the display device which displays the concentration of the predetermined body fluid component; andthe memory of the sensor unit storing ...

Cardiac stimulation system

Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue. In certain embodiments, the wireless electrode assembly may include one or more biased tines that shift from a first position to a second position to secure the wireless electrode assembly into the inner wall of the heart chamber.

CLASSIFICATION OF TUMOR TISSUE WITH A PERSONALIZED THRESHOLD

The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database. 1. A system for obtaining at least one threshold for the discrimination among different tissue types , the system comprising:an optical probe arranged for obtaining light measurements at one or more positions in a tissue of a first type; anda console arranged for spectrally analyzing the light measurements and defining data points in a score plot of a multivariate statistical analysis to form a first tissue type class on the basis of predetermined spectral characteristics derived from fits in the light measurements, wherein the console is arranged for defining a first threshold for the cloud of data points belonging to this first tissue type class by using spectral characteristics of reference tissue,wherein the optical probe is further arranged for obtaining further light measurements at further positions in the tissue; andwherein the console is further arranged for testing whether the predetermined spectral characteristics of the further light measurements fall outside the first threshold in said score plot and if this is the ...

Instrument Penetration Detector Using Dynamic Frequency Adjustment, and Method of Operation

A method, and an apparatus to perform the method, of determining a location of a medical instrument in a patient during a medical procedure, the method including connecting at least a portion of the medical instrument to a first body region of the patient, propagating a plurality of signals at different frequencies along a conductive path of the medical instrument, measuring one or more feedback parameters corresponding to each of the plurality of signals at the first body region, determining an operational frequency from the different frequencies according to a comparison of the one or more feedback parameters, propagating a signal having the operational frequency along the conductive path as the medical instrument penetrates the body of the patient during the medical procedure, and measuring the one or more feedback parameters corresponding to the operational frequency to determine a penetration location of the medical instrument in the body of the patient. 1. A method of determining a location of a medical instrument in a patient during a medical procedure , the method comprising:connecting at least a portion of the medical instrument to a first body region of the patient;propagating a plurality of signals at different frequencies along a conductive path of the medical instrument;measuring one or more feedback parameters corresponding to each of the plurality of signals at the first body region;determining an operational frequency from the different frequencies according to a comparison of the one or more feedback parameters;propagating a signal having the operational frequency along the conductive path as the medical instrument penetrates the body of the patient during the medical procedure; andmeasuring the one or more feedback parameters corresponding to the operational frequency to determine a penetration location of the medical instrument in the body of the patient.2. The method of claim 1 , further comprising generating at least one indicator to indicate ...

METHODS FOR LOCALIZING IMPLANTED VASCULAR ACCESS DEVICES

Disclosed are vascular access devices, implantable dialysis grafts, and systems including them useful for improved access to implanted medical devices. Also disclosed are implantable hemodialysis vascular access graft devices that facilitate easy, accurate and reproducible cannulation or needle entry into the implanted device by magnetically-locating a portion of the graft that includes one or more paramagnetic materials operably defining the physical boundaries of the target cannulation site/entry port. 135-. (canceled)36. A method for identifying the placement of an implanted dialysis graft that comprises at least a first and a second region each including a substantially magnetic or a substantially paramagnetic material and each positioned longitudinally along the substantially tubular dialysis graft thereby defining a first cannulation site within the graft , the method comprising , localizing the presence of the first cannulation site by passing over the skin proximate to the implant a detector that comprises one or more magnets sized and dimensioned to correspond to , and to localize to , the first cannulation site within the graft , by the attraction of the one or more magnets within the detector to the first and the second regions of the device that include the magnetic or the paramagnetic material , thereby identifying the first cannulation site within the implanted dialysis graft.37. A method for improving the accuracy of localization and cannulation of an implanted AV graft device , comprising , 1) employing a system that comprises (a) a vascular device; and (b) at least one magnet sized and dimensioned to detect the implanted vascular graft when placed in proximity to the skin of a patient into which the graft or device has been implanted to preferentially identify the location of at least a first cannulation site within the graft that is defined by the position of a plurality of magnetic or paramagnetic rings disposed along , on , or within the graft ...

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Calibration Methods for a Bandage-Type Analyte Sensor

A flexible, body-mountable analyte sensing device includes a flexible substrate configured for mounting to skin of a living body. The sensing device additionally includes a sensor probe attached to the flexible substrate and configured to penetrate the skin such that a sensor disposed on the end of the sensor probe can be exposed to an analyte in interstitial fluid. The sensor could be an electrochemical sensor that includes two or more electrodes disposed at the end of the sensor probe and configured to electrochemically detect the analyte. The sensing device is configured to display detected concentrations or other information about the analyte in the interstitial fluid. The flexible substrate of the sensing device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the living body. 1. A body-mountable device comprising:a flexible substrate, wherein the flexible substrate is configured to be mounted to a skin surface;a sensor configured to generate an electrical signal, wherein the electrical signal is related to a physiological property;an analog-to-digital converter, wherein the analog-to-digital converter is configured to receive the electrical signal generated by the sensor and to generate digital codes related to the received electrical signal, wherein the analog-to-digital converter is disposed on the flexible substrate; and obtaining calibration data;', 'operating the sensor to generate a plurality of samples of the electrical signal related to the physiological property;', 'operating the analog-to-digital converter to generate a plurality of digital codes corresponding to respective samples of the electrical signal generated by the sensor;', 'recording the generated plurality of digital codes;', 'determining that a trigger condition is met; and', 'determining, responsive to determining that the trigger condition is met, at least one value of the physiological property based on at least one recorded ...

Automated measurement and control system for tattoo delivery

Tattooing, or delivery of pigment into the skin, producing temporary or permanent markings on the skin, is practiced for aesthetic and practical purposes. Human and mechanical control of tattooing may be augmented by sensors, coupled to an adaptive control system capable of improving the results, and relieving demands on the operator.

DIAGNOSIS AND TREATMENT OF TISSUE

A method of evaluating an image indicating a potential presence of a cancer lesion at a location within a prostate of a patient by transmitting light from an optical probe toward a location, receiving fluorescence spectra by the optical probe from the location, and generating a visual display of a diagnosis classification so as to confirm or contradict the existence of the cancer lesion at the location. 1. A method of evaluating an image indicating a potential presence of a cancer lesion at a location within a prostate of a patient , the method comprising:positioning an optical probe so as to target the location within the prostate of the patient;transmitting light from the optical probe toward the location and receiving fluorescence spectra by the optical probe from the location which is utilized by a tissue classification system having at least one algorithm that generates a diagnosis classification based only on selected data of the fluorescence spectra; andgenerating a visual display of the diagnosis classification at the location overlapping the image so as to confirm or contradict the existence of the cancer lesion at the location.2. A method as in claim 1 , wherein the image comprises an MRI image claim 1 , an ultrasound image claim 1 , a CT image or an MM image.3. A method as in claim 1 , wherein the image comprises an MRI/US fusion image.4. A method as in claim 1 , wherein the diagnosis classification is visualized on the visual display by a color indicating the diagnosis classification.5. A method as in claim 1 , further comprising selecting a view for the visual display wherein the view comprises a two-dimensional image or a three-dimensional image.6. A method as in claim 1 , further comprising selecting an option for the visual display claim 1 , wherein the option comprises a black-and-white image claim 1 , a color image claim 1 , and/or a line image.7. A method as in claim 1 , wherein positioning the probe comprises introducing the probe under ...

Wireless sensors and corresponding systems and methods for intra-operative nerve root decompression monitoring

A sensor including an array of pins, a sensing element, a control module, and a physical layer module. The array of pins or needles is configured to be inserted in tissue of a patient. The sensing element is separate from the array of pins or needles and is configured to (i) detect a first parameter of the tissue, and (ii) generate a first signal indicative of the first parameter. The control module is configured to (i) receive the first signal, (ii) monitor a second parameter of the tissue based on a second signal received from the array of pins or needles, and (ii) generate a third signal based on the first signal and the second parameter, where the third signal is indicative of a level of decompression of a nerve of the patient. The physical layer module is configured to wirelessly transmit the third signal from the sensor to a console interface module or a nerve integrity monitoring device.

Apparatus and Method for Assessment of Interstitial Tissue

A handheld optical coherence tomography imaging and tissue sampling system and method of imaging and sampling a tissue is disclosed. The method includes inserting a catheter probe into a biopsy needle. The biopsy needle can be attached to a hand-held scanning and sampling device. The biopsy needle is maneuvered to an investigation site. A three-dimensional image of the tissue at the investigation site is captured with the catheter probe.

REAL-TIME AND LABEL FREE ANALYZER FOR IN-VITRO AND IN-VIVO DETECTING THE SUSPICIOUS REGIONS TO CANCER

An apparatus for in-vivo measuring HOoxidation within a living tissue. The apparatus includes an electrochemical probe and an electrochemical stimulator-analyzer. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode, a counter electrode, and a reference electrode. The working electrode includes a first biocompatible conductive needle coated with a layer of vertically aligned multi-walled carbon nanotubes. The counter electrode includes a second biocompatible conductive needle. The reference electrode includes a third biocompatible conductive needle. The electrochemical stimulator-analyzer is configured to generate a set of electrical currents in a portion of the living tissue. 1. An apparatus for in-vivo measuring HOoxidation within a living tissue , comprising: [ a working electrode comprising a first biocompatible conductive needle coated with a layer of vertically aligned multi-walled carbon nanotubes (VAMWCNTs);', 'a counter electrode comprising a second biocompatible conductive needle; and', 'a reference electrode comprising a third biocompatible conductive needle; and, 'a sensing part, comprising, 'a handle, comprising an insertion part attached to the sensing part, the insertion part configured to be inserted the into a portion of the living tissue; and', generate a set of electrical currents in the portion of the living tissue by applying a set of electrical potentials to the electrochemical probe; and', 'record the set of electrical currents by measuring an electric current flowing from the counter electrode to the working electrode., 'an electrochemical stimulator-analyzer configured to], 'an electrochemical probe comprising2. The method of claim 1 , wherein electrochemical stimulator-analyzer is further configured to:apply the set of electrical potentials by applying a sweeping range of electrical potentials between −1 V and 1 V to the working electrode; andmeasure the electric currents at the ...

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Medical device inserters and processes of inserting and using medical devices

An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Embodiments include removing a substantially cylindrical cap from an inserter to expose a substantially cylindrical sleeve, removing a cover from a substantially cylindrical container holding sensor components, and fitting the sensor components into the inserter.

Photoacoustic measurement apparatus

A photoacoustic measurement apparatus includes: a main light source; a sub-light source; a light guide member that guides the light which has been emitted from the main light source and the sub-light source and has been incident on a base end to a leading end; an insert of which at least a leading end portion is inserted into a subject and which includes at least the leading end of the light guide member and a light absorption member that absorbs the pulsed laser light, and generates photoacoustic waves; and a photoacoustic wave detection unit that detects the photoacoustic waves. The photoacoustic measurement apparatus has, as an operation mode, a failure detection mode that drives the sub-light source and detects a failure of a photoacoustic wave generation unit including the light guide member and the light absorption member.

METHOD AND APPARATUS FOR MINIMALLY INVASIVE INSERTION OF INTERVERTEBRAL IMPLANTS

A dilation introducer for orthopedic surgery is provided for minimally invasive access for insertion of an intervertebral implant. The dilation introducer may be used to provide an access position through Kambin's triangle from a posterolateral approach. A first dilator tube with a first longitudinal axis is provided. An access cannula may be introduced over the first dilator tube. A drill may be inserted through the access cannula and used to perform a foraminoplasty. Surgical instruments may pass through the access cannula to operate on an intervertebral disc and/or insert an intervertebral implant. 127-. (canceled)28. A method of performing an endoscopic procedure through a Kambin's triangle of a human , the method comprising the steps of:introducing a Jamshidi® needle through the Kambin's triangle so as to define a path to an intervertebral disc space, wherein the Jamshidi® needle includes a removable handle;removing the handle from the Jamshidi® needle;after the removing step, advancing at least one dilation tube over the Jamshidi® needle through the Kambin's triangle; andafter the advancing step, advancing an access cannula over the at least one dilation tube through the Kambin's triangle, and removing the at least one dilation tube from the access cannula; andperforming the endoscopic procedure on the intervertebral disc space using the at least one surgical tool through the access cannula.29. The method as recited in claim 28 , wherein the step of advancing the access cannula comprises abutting an intervertebral disc with the access cannula.30. The method as recited in claim 28 , wherein the intervertebral disc space is defined between a superior vertebra and an inferior vertebral vertebra claim 28 , the method further comprising the step of removing bone from the inferior vertebra so as to enlarge the Kambin's triangle.31. The method as recited in claim 30 , wherein the step of removing bone comprises removing bone from a superior articular process of the ...

METHOD AND APPARATUS FOR MINIMALLY INVASIVE INSERTION OF INTERVERTEBRAL IMPLANTS

A dilation introducer for orthopedic surgery is provided for minimally invasive access for insertion of an intervertebral implant. The dilation introducer may be used to provide an access position through Kambin's triangle from a posterolateral approach. A first dilator tube with a first longitudinal axis is provided. An access cannula may be introduced over the first dilator tube. A drill may be inserted through the access cannula and used to perform a foraminoplasty. Surgical instruments may pass through the access cannula to operate on an intervertebral disc and/or insert an intervertebral implant. 127-. (canceled)28. A method for accessing a patient's intervertebral disc to be treated in orthopedic surgery through a Kambin's triangle , the method comprising the steps of:passing an instrument along a first longitudinal axis until it abuts a superior articular process of a vertebra;passing an access cannula over the instrument along an axis, wherein the access cannula has a discontinuous outer perimeter along a plane that is oriented perpendicular to the axis;passing a drill bit through the access cannula until it abuts the superior articular process of the vertebra; anddrilling along the first longitudinal axis to the intervertebral disc so as to remove bone from the superior articulating process.29. The method as recited in claim 28 , wherein the first longitudinal axis defines a posterolateral trajectory.30. The method as recited in claim 29 , wherein the posterolateral trajectory is between about 45 and 55 degrees with respect to the sagittal plane.31. The method as recited in claim 28 , wherein drilling along the first longitudinal axis comprises using a power drill.32. The method as recited in claim 28 , further comprising removing the drill bit while leaving the access cannula in place.33. The method as recited in claim 32 , further comprising accessing the intervertebral disc by passing surgical tools through the access cannula.34. The method as recited in ...

METHOD AND APPARATUS FOR MINIMALLY INVASIVE INSERTION OF INTERVERTEBRAL IMPLANTS

A dilation introducer for orthopedic surgery is provided for minimally invasive access for insertion of an intervertebral implant. The dilation introducer may be used to provide an access position through Kambin's triangle from a posterolateral approach. A first dilator tube with a first longitudinal axis is provided. An access cannula may be introduced over the first dilator tube. A drill may be inserted through the access cannula and used to perform a foraminoplasty. Surgical instruments may pass through the access cannula to operate on an intervertebral disc and/or insert an intervertebral implant. 127-. (canceled)28. A method of performing an endoscopic procedure through a Kambin's triangle of a human , the method comprising the steps of:introducing an access cannula through the Kambin's triangle toward an intervertebral space that is defined between a superior vertebra and an inferior vertebra;inserting an intervertebral implant through the access cannula and into the intervertebral space in a collapsed position whereby opposed vertebral facing surfaces face respective ones of the superior and inferior vertebrae;after the inserting step, expanding the intervertebral implant so as to cause the opposed vertebral facing surfaces to bear against the respective ones of the superior and inferior vertebrae; anddriving a pedicle screw into one of the superior and inferior vertebrae.29. The method as recited in claim 28 , wherein the opposed vertebral facing surfaces are substantially planar.30. The method as recited in claim 28 , further comprising the step of removing bone from a superior articular process of the inferior vertebra.31. The method as recited in claim 30 , wherein the step of removing bone comprises rotating a drill bit.32. The method as recited in claim 28 , further comprising the step of inserting a dilation tube along a trajectory through Kambin's triangle claim 28 , and introducing the access cannula over the dilation tube.33. The method as recited ...

Integrated Injection System and Communication Device

An integrated system for injection including an injection device in electronic connection with a communication device is provided. The external communication device may be a handheld electronic device such as a Smartphone or a dedicated reader such as a reader capable of reading information contained on an RFID tag. The injection device includes a needle and a drug delivery portion enclosed within an external housing. Optionally, a plurality of sensors is affixed to the surface of the needle to collect data about the injection and physical characteristics of the patient. The data may be recorded on a data capture module. The electronic chip may be a readable and writable electronic chip such as a non-volatile memory chip. Alternatively, the electronic chip is a passive RFID tag. The injection device may further include a data transmitter for sending information obtained from the data capture module to the external communications device. 1. An integrated injection system , the system comprising an injection device comprising a drug delivery portion and a data transmitter , and a communication device that is external to the injection device ,wherein the injection device further comprises a data capture module including at least one sensor, the module being configured to sense information about at least one of a physical condition and a behavior of a patient during an injection event by the at least one sensor,wherein the data transmitter is configured to be in electronic communication with the communication device,wherein the data transmitter is configured to transmit at least a portion of the sensed information to the communication device,wherein the injection device further comprises an external housing enclosing the drug delivery portion and the data transmitter,wherein the drug delivery portion includes an internal reservoir containing a pharmaceutical agent to be delivered to the patient, wherein the internal reservoir is formed within a substrate layer of the ...

TRANSCUTANEOUS ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A sensor system for measuring an analyte concentration in a host , the sensor system comprising:a sensor comprising at least one electrode; andsensor electronics configured to measure the analyte concentration in the host when the sensor is implanted therein, wherein the sensor electronics comprise a data sampling portion in data communication with the at least one electrode, wherein the data sampling portion comprises an analog portion configured to measure the current flowing at the at least one electrode and to convert the current measurement to digital values representative of the current, wherein the digital values are acquired at a predetermined time interval.2. The system of claim 1 , wherein the predetermined time interval is programmed.3. The system of claim 1 , wherein the predetermined time interval is programmable.4. The system of claim 1 , wherein the predetermined time interval is programmable at an interval from about 6 seconds to about 3600 seconds.5. The system of claim 1 , wherein the sensor electronics comprise a transmitter portion for transmitting a signal indicating a level of the analyte in the host at a programmable transmission interval.6. The system of claim 5 , wherein the programmable transmission interval is a multiple of the predetermined time interval.7. The system of claim 5 , wherein the transmission interval is programmable from about 30 seconds to about 60 minutes.8. The system of claim 1 , wherein the sensor electronics are configured to measure the current flow in at least a picoAmp range.9. The system of claim 1 , wherein the sensor electronics comprise an integrated circuit.10. The system of claim 9 , wherein the integrated circuit comprises the data sampling portion.11. The system of claim 1 , wherein ...

Methods, systems, and apparatuses for detecting activation of an electronic device

Disclosed are devices and methods for detecting activation of an electronic device, including a biomedical and biometric device. The electronic device can operate in a low-power mode until it is determined that the electronic device is in close proximity to or in contact with a body, and activated. The electronic device can include a first sensor including a first capacitance sensor, a second sensor, and a controller coupled to the first sensor and the second sensor. The controller can receive a first signal from the first sensor and determine that the electronic device is in close proximity to or in contact with a body based on the first signal, and receive a second signal from the second sensor and determine that the electronic device is activated based on one or both of the first signal and the second signal. The electronic device can transition from the low-power mode to an active mode in response to determining that the electronic device is activated.

BIOPSY NEEDLE AND PHOTOACOUSTIC MEASUREMENT APPARATUS

In a biopsy needle having a hollow tubular outer needle, an inner needle that is disposed in a hollow portion of the outer needle so as to be movable in the tube axis direction relative to the outer needle, and a recessed sample collection portion that is cut inward from a circumferential surface of the inner needle, an outer groove extending in the tube axis direction of the outer needle is provided on at least the distal end side and the rear end side of the sample collection portion in the inner needle, and a light guide member is disposed in the outer groove. At least a part of the light guide member is fixed by fillers filled in the outer groove. 1. A biopsy needle , comprising:a hollow tubular outer needle;an inner needle that is movable in a tube axis direction relative to the outer needle and that is disposed in a hollow portion of the outer needle;a sample collection portion that has a recessed shape and that is provided on a circumferential surface of the inner needle;an outer groove that is provided on each of at least a distal end side and a rear end side of the sample collection portion in the inner needle and that is opened to the circumferential surface of the inner needle and extends in the tube axis direction;a first light guide member that is disposed in the outer groove and that is disposed from the rear end side of the inner needle to vicinity of the distal end of the inner needle;a first light absorber that absorbs light emitted from a distal end of the first light guide member and emits a photoacoustic wave; anda filler that is filled in the outer groove to fix at least a part of the first light guide member.2. The biopsy needle according to claim 1 ,wherein the filler disposed in the outer groove provided on the distal end side of the sample collection portion in the inner needle also serves as the first light absorber.3. The biopsy needle according to claim 1 ,wherein the first light guide member is fixed to a bottom surface of the sample ...

APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media. 1. A catheter for sensing the activity from nerves outside of the lumen of a target vessel of a human body comprising:a catheter body having a distal end for insertion into a patient, a proximal end for controlling the movement of at least one needle, and a central axis extending in a longitudinal direction;a connector configured to connect to external electronic equipment outside of a proximal end of the catheter, said equipment having a sensing subsystem configured for sensing local nerve activity within a patient, and configured to be connected to at least one additional electrode in electrical contact with the patient;at least one needle guiding element adapted to expand outwardly from the catheter body toward the interior wall of the target vessel;at least one needle, the needle having at least one distal electrode, the needle adapted to be advanced outwardly, guided by the at least one needle guiding element to penetrate and advance through the interior wall of the ...

Transcutaneous analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

PROBE FOR OPTICAL SPECTROSCOPY

A probe () comprising a body portion () and a tip portion (). The body portion comprises: a first mounting portion () comprising a plurality of first carriers supporting elongate first waveguides, and disposed in an equiangular arrangement around a longitudinal axis (A) of the body portion; a body end fitting () at which first ends of the first waveguides are supported such that the first waveguides can transmit electromagnetic radiation signals from an energy source to the body end fitting and/or transmit electromagnetic radiation signals from the body end fitting to a receiver. The tip portion comprises: a second mounting portion () comprising a plurality of second carriers supporting elongate second waveguides, the second carriers being disposed in the equiangular arrangement around a longitudinal axis of the tip portion; and a tip end fitting () at which first ends of the second waveguides are supported in the equiangular arrangement around the longitudinal axis of the tip portion; and an elongate conduit () for piercing human tissue. 1. A probe comprising: a first mounting portion comprising a plurality of first carriers, each first carrier being arranged to support an elongate first waveguide, the first carriers being disposed in an equiangular arrangement around a longitudinal axis of the body portion;', 'a plurality of first waveguides, each first waveguide being supported in a respective one of the plurality of first carriers; and', 'a body end fitting at which first ends of the first waveguides are supported in the equiangular arrangement around the longitudinal axis of the body portion such that the first waveguides can transmit electromagnetic radiation signals from an energy source to the body end fitting and/or transmit electromagnetic radiation signals from the body end fitting to a receiver; and, 'a body portion, the body portion comprising a second mounting portion comprising a plurality of second carriers, each second carrier being arranged to ...

Intravascular catheter with peri-vascular nerve activity sensors

An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

NEEDLE ASSEMBLY WITH TEMPERATURE MEASUREMENT DEVICE

A needle assembly includes an elongated, hollow, hypodermic needle and a temperature measurement device at least partially disposed within the needle. The temperature measurement device comprises a plurality of parallel thermal sensors collectively retained in a fixed relationship within a common dielectric sheath. Each thermal sensor includes a temperature-sensing region which is capable of generating a voltage in proportion to the sensed temperature. The temperature-sensing regions for the plurality of thermal sensors are arranged in an offset relationship within the hypodermic needle, with each temperature-sensing region located at a different position relative to the sharpened tip of the hypodermic needle. Accordingly, in use, needle assembly is designed to compile temperature measurements at multiple locations along the length of the needle, thereby yielding a comprehensive and accurate temperature profile of the body into which the hypodermic needle is inserted. 1. A needle assembly , comprising:(a) an elongated, hollow needle having a first end and a second end; and(b) a temperature measurement device at least partially disposed within the needle, the temperature measurement device comprising a plurality of thermal sensors, each thermal sensor comprising a temperature-sensing region;(c) wherein the temperature-sensing regions for the plurality of thermal sensors are located within the hollow needle at different positions relative to the first end.2. The needle assembly as claimed in further comprising a tubular sheath into which the plurality of thermal sensors is coaxially disposed.3. The needle assembly as claimed in wherein the temperature-sensing regions for the plurality of thermal sensors is located within the tubular sheath.4. The needle assembly as claimed in wherein the tubular sheath is constructed of a dielectric material.5. The needle assembly as claimed in wherein the temperature-sensing regions for the plurality of thermal sensors are ...

SENSOR HOLDER DEVICE FOR INVASIVE BIOSENSORS

In some examples, a sensor holder device is described. The sensor holder device may include a rigid body, a set legs attached to the rigid body, a sensor guiding structure, a sensor retaining structure, and an electrical trace. The sensor retaining structure may be sized to accommodate a sensor wire. The electrical trace may extend proximate the sensor retaining structure and along one of the legs. 1. A sensor holder device , comprising: a rigid body; a set of legs attached to the rigid body and extending from one side of the rigid body; a sensor guiding structure attached to the rigid body and extending from the one side of the rigid body , the sensor guiding structure defining a guiding hole or a guiding opening , wherein the rigid body comprises a groove that extends from the sensor guiding structure and is sized to accommodate a sensor wire; and an electrical trace electrically coupling the groove and a distal end of a first leg of the set of legs.2. The sensor holder device of claim 1 , wherein the groove is formed on the one side of the rigid body or on a side of the rigid body that is opposite the one side.3. The sensor holder device of claim 1 , wherein the groove defines: a first region having a first cross-sectional area and sized to accommodate a first portion of the sensor wire; and a second region having a second cross-sectional area and sized to accommodate a second portion of the sensor wire claim 1 , the first cross-sectional area being different from the second cross-sectional area.4. The sensor holder device of claim 1 , wherein the guiding hole intersects with the groove and terminates at a distal end of the sensor guiding structure disposed below the rigid body.5. The sensor holder device of claim 4 , wherein: the rigid body is oriented in a first plane; and the distal end of the sensor guiding structure and the distal end of the first leg are oriented in a second plane claim 4 , the first plane different from the second plane.6. The sensor ...

Fiber Optic Device for Sensing Analytes and Method of Making Same

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

CONTINUOUS GLUCOSE MONITORING ON-BODY SENSOR

An on-body sensor (OBS) () having a continuous monitoring (CGM) device is disclosed for use in identifying an analyte, such as glucose in blood or interstitial fluid (ISF), using a biomaterial, such as glucose binding protein (GBP), that is brought into contact with the analyte. The on-body sensor () incorporating the CGM device includes a housing () which provides protection to the CGM device while providing comfort to a user wearing the device. The OBS also includes an adhesive structure that provides a comfortable, discreet and secure user experience. 1. An on-body device for sensing an analyte in a living body , comprising:a cover at least partially containing a glucose monitoring sensor; anda first bottom surface adapted to be adhered to skin, and further adapted to reduce at least one of skin irritation and nuisance to a user.2. The on-body device of claim 1 , further comprising a handle adapted to force the cover in a direction of a user.3. The on-body device of claim 2 , wherein the handle is removable.4. The on-body device of claim 2 , wherein the handle is made of a fabric material.5. The on-body device of claim 2 , wherein the handle has a substantially narrow and elongated shape claim 2 , and wherein the cover is formed by silicone.6. The on-body device of claim 2 , wherein the cover and the handle have an hourglass-like shape.7. The on-body device of claim 1 , wherein the first bottom surface comprises a first adhesive.8. The on-body device of claim 7 , further comprising a first adhesive release paper that can be removed to expose the first adhesive9. The on-body device of claim 8 , first adhesive release paper comprises opposing flaps that are adapted to be joined together above the cover.10. The on-body device of claim 1 , further comprising a handle hinged to a top surface of the cover.11. The on-body device of claim 10 , wherein the handle is adapted to be rotated to a substantially parallel position with respect to a top surface of the cover.12. ...

NEUROMONITORING PROBE SYSTEMS AND METHODS

A neuromonitoring system comprises a plurality of needle electrodes, a ground electrode, a monopolar stimulating probe having an electrode tip and configured to be coupled to a cable, and a stimulating probe sleeve. The sleeve is adapted and configured to be removably coupled to the monopolar stimulating probe. The sleeve has a slot and is configured and adapted to coaxially slide relative to the monopolar stimulating probe between a first retracted position and a second advanced position. The electrode tip generates an omnidirectional signal when in use while the sleeve is in the retracted position or in an uncoupled position. The electrode tip generates a unidirectional signal when in use while the sleeve is in the advanced position. 1. A neuromonitoring system comprising:a plurality of needle electrodes;a ground electrode;a monopolar stimulating probe having an electrode tip and configured to be coupled to a cable; anda stimulating probe sleeve adapted and configured to be removably coupled to the monopolar stimulating probe, wherein the sleeve has a slot and is configured and adapted to coaxially slide relative to the monopolar stimulating probe between a first retracted position and a second advanced position, wherein the electrode tip generates an omnidirectional signal when in use while the sleeve is in the retracted position or in an uncoupled position, and wherein the electrode tip generates a unidirectional signal when in use while the sleeve is in the advanced position.2. The system of claim 1 , comprising a slot extending an entire length of the sleeve from a proximal portion to a distal portion.3. The system of claim 1 , comprising a slot extending a partial length of the sleeve.4. The system of claim 1 , wherein the sleeve is rotatable about a longitudinal axis of the stimulating probe when coupled.5. The system of claim 1 , wherein the sleeve has a tapered shape.6. The system of claim 1 , wherein the probe is disposable.7. The system of claim 1 , ...

Device for Biosensing With Indwelling Venous Catheter

The specification and drawings show an embodiment of the present invention in the form of a device comprising one or more biosensors either placed or imbedded in a catheter, needle or combination of the two. The catheter or needle comprises exclusionary slits upstream of the biosensor(s), angled so that fluid flows in through the slits and down past the biosensors. The wires connecting the biosensors to external monitoring and/or analytical apparatus are wired through the catheter or needle material. Also provided herein are methods for detection of small molecules using the device described herein. 1. A device comprising a catheter or needle comprising a lumen , a proximal opening , a distal opening , a plurality of exclusionary slits , at least one sensor , and wiring connected to the sensor , wherein the wiring is configured to permit an external connection at the proximal end of the device.2. The device of claim 1 , wherein the sensor is mounted to the interior wall of the catheter or needle.3. The device of claim 1 , wherein the sensor is positioned within the lumen.4. The device of claim 3 , wherein the sensor is slidably positioned within the lumen.5. The device of claim 4 , wherein the device is configured to permit the sensor to be positioned outside the lumen following insertion of the catheter or needle into a subject.6. The device of claim 1 , wherein the sensor is an aptasensor claim 1 , enzyme sensor claim 1 , or ion-sensitive field-effect transistor sensor.7. The device of claim 1 , wherein the slits are located closer to the proximal opening than the sensor.8. The device of claim 1 , wherein the sensor is located at the distal end of the device.9. The device of claim 1 , wherein the slits are small enough to exclude blood cells and proteins while allowing plasma to pass through.10. The device of claim 1 , wherein the slits are configured to reduce flow of fluid through the lumen past the biosensor.11. The device of claim 1 , wherein the wiring ...

Stapedius Muscle Reflex Recording Electrode with a Sacrificial Part

A stapedius muscle recording electrode arrangement is described having one or more wire electrodes with an inner conducting wire covered by an outer layer of electrical insulation. There is an electrode opening in the electrical insulation that exposes underlying conducting wire. A curved needle has a tip configured for insertion into stapedius muscle tissue, and a base end coupled to the at least one wire electrode. The wire electrode and the needle are configured for insertion of the curved needle through the stapedius muscle tissue or between the stapedius muscle surface and the inner bony surface of the pyramidal eminence to embed the wire electrode in the stapedius muscle tissue or between the stapedius muscle surface and the inner bony surface of the pyramidal eminence for electrical interaction of the conducting wire at the electrode opening with the stapedius muscle tissue. 1. A stapedius muscle electrode arrangement comprising:at least one wire electrode having an inner conducting wire covered by an outer layer of electrical insulation with an electrode opening that exposes underlying conducting wire; and i. a tip configured for insertion into contact with stapedius muscle tissue, and', 'ii. a base end coupled to the at least one wire electrode;, 'a curved needle havingwherein the at least one wire electrode and the curved needle are configured for insertion of the needle through or along the stapedius muscle tissue to embed the at least one wire electrode into galvanic contact with the stapedius muscle tissue to provide for electrical interaction of the conductive wire with the stapedius muscle tissue.2. The electrode arrangement according to claim 1 , wherein a section of suture material couples the base end of the curved needle to the at least one wire electrode.3. The electrode arrangement according to claim 1 , further comprising:a ball shaped electrode contact at each electrode opening connected to the underlying conducting wire and extending out ...

Systemized and Method for Optimized Medical Component Insertion Monitoring and Imaging Enhancement

According to one embodiment, a guidance system is described for assisting in an advancement of a medical component within a body of a patient. The guidance system features a probe and a console. The console is communicatively coupled to the probe and features AI-based visualization controls and AI-based guidance assistance logic. The AI-based visualization controls are configured to generate, position, and reposition a visualization area between the medical component and a targeted vasculature of the patient. The visualization area is a sub-region of a total imaging area rendered by the console. The AI-based guidance assistance logic is configured to monitor for a presence of the medical component within the visualization area, provide a feedback for generating a notification that the medical component is within the visualization area, and apply an imaging enhancement to at least a portion of imaged data within the visualization area to assist in the advancement. 1. A guidance system , comprising:a probe; anda console communicatively coupled to the probe, the console comprises a sensor analytic logic to (i) monitor for a presence of a medical component within a visualization area being a subset of a total imaging area rendered by the guidance system and proximate to a targeted destination and (ii) provide feedback to a device for generating a notification of the presence of the medical component within the visualization area.2. The guidance system as defined in claim 1 , wherein the sensor analytic logic is configured to monitor for needle feedback from sound waves emitted and recovered by the probe.3. The guidance system as defined in claim 1 , wherein the medical component is a needle from which a needle reflection is detected when the probe is operating as a part of an ultrasound system.4. The guidance system as defined in claim 1 , wherein the sensor analytic logic is configured to monitor for needle feedback based on a magnetic field detected by the probe based ...

ELECTROCHEMICAL BIOSENSING OF CANCER-INVOLVED LYMPH NODES

A method for detecting cancerous status of a suspected lymph node (LN) to be cancerous. The method includes measuring fatty acid oxidation (FAO) in the suspected LN by measuring a charge transfer resistance (R) associated with the suspected LN, and detecting, utilizing one or more processors, a cancerous status of the suspected LN. Detecting the cancerous status of the suspected LN includes detecting the suspected LN is cancer involved if the measured Ris less than a reference Rvalue, or detecting the suspected LN is healthy if the measured Ris more than the reference Rvalue. 1. A method for detecting cancerous status of a suspected lymph node (LN) to be cancerous , comprising:forming a lipid detection probe (LDP) by forming three lipid sensitive parts at three respective distal ends of three hollow needle electrodes by laser-assisted welding of a layer of carbon nanotubes (CNTs) onto surface of the respective distal ends of three platinum hollow needles;connecting a proximal end of each respective hollow needle electrode to an electrochemical stimulator-analyzer device;inserting the three lipid sensitive parts into the suspected LN;injecting a biocompatible electrolyte solution into the LN through a respective proximal end of at least one hollow needle electrode of the three hollow needle electrodes;{'sub': 'CT', 'claim-text': recording an electrochemical impedance spectroscopy (EIS) from the suspected LN utilizing the LDP and the electrochemical stimulator-analyzer device, the recorded EIS comprising a pseudo-semicircular-shaped curve; and', {'sub': 'CT', 'claim-text': forming a semicircle curve by complementing the pseudo-semicircular-shaped curve; and', 'measuring a diameter of the semicircle curve; and, 'calculating Rof the recorded EIS utilizing one or more processors, comprising], 'measuring fatty acid oxidation (FAO) in the suspected LN by measuring a charge transfer resistance (R) associated with the suspected LN, comprising [{'sub': 'CT', 'detecting the ...

Wireless Sensors For Nerve Integrity Monitoring Systems

A sensor including electrodes, a control module and a physical layer module. The electrodes are configured to (i) attach to a patient, and (ii) receive a first electromyographic signal from the patient. The control module is connected to the electrodes. The control module is configured to (i) detect the first electromyographic signal, and (ii) generate a first voltage signal. The physical layer module is configured to: receive a payload request from a console interface module or a nerve integrity monitoring device; and based on the payload request, (i) upconvert the first voltage signal to a first radio frequency signal, and (ii) wirelessly transmit the first radio frequency signal from the sensor to the console interface module or the nerve integrity monitoring device.

Sensors for continuous analyte monitoring, and related methods

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

SUB-EPIDERMAL ELECTRIC WARNING DEVICE

A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention. 1. A sub-epidermal electric warning device , comprising:electrodes to penetrate through a patient's epidermis into sub-epidermal tissue; andcircuitry to transmit unipolar voltage pulses to the electrodes, the unipolar voltage pulses to create bipolar current pulses of alternating positive and negative polarity in the sub-epidermal tissue.2. The sub-epidermal warning device according to claim 1 , wherein:the electrodes are electrically connected to each other to have a same potential during a portion of the unipolar voltage pulses.3. The sub-epidermal warning device according to claim 2 , wherein:one of the electrodes is grounded, and another of the electrodes is electrically connected to a power source during another portion of the unipolar voltage pulses which is different than said portion of the unipolar voltage pulses.4. The sub-epidermal warning device according to claim 3 , wherein:the unipolar voltage pulses include a rising edge and a falling edge,when the unipolar voltage pulses are at the rising edge, the bipolar current pulses have a first polarity, andwhen the unipolar voltage pulses are at the falling edge, the bipolar current pulses transition to a second polarity that is opposite to the first polarity.5. The sub-epidermal warning device according to claim 1 , wherein:the unipolar voltage pulses include a rising edge and a falling edge,when the unipolar voltage pulses are at the rising edge, the bipolar current pulses have a first polarity, andwhen the unipolar voltage pulses are at the falling edge, the bipolar current pulses transition to a second polarity that ...

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

REAL-TIME AND LABEL-FREE APPROACH FOR CANCER DIAGNOSIS

An electrochemical probe for in-vivo measurement of HOoxidation within a living tissue. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode including a first biocompatible conductive needle, a counter electrode including a second biocompatible conductive needle, and a reference electrode including a third biocompatible conductive needle. The working electrode, the counter electrode, and the reference electrode are configured to put in contact with the living tissue by inserting the sensing part into the living tissue. The handle includes an insertion part that may be configured to insert the sensing part into the living tissue. The sensing part is attached to the insertion part. 117-. (canceled)18- An electrochemical probe for in-vivo measurement of HOoxidation within a living tissue , comprising: a working electrode comprising a first biocompatible conductive needle;', 'a counter electrode comprising a second biocompatible conductive needle; and', 'a reference electrode comprising a third biocompatible conductive needle,', 'wherein the working electrode, the counter electrode, and the reference electrode are configured to be put in contact with the living tissue by inserting the sensing part into the living tissue; and, 'a sensing part, comprisinga handle comprising an insertion part configured to insert the sensing part into the living tissue,wherein the sensing part is attached to the insertion part.191- The electrochemical probe of claim , wherein each of the first biocompatible conductive needle , the second biocompatible conductive needle , and the third biocompatible conductive needle comprises respective sensing tips , each sensing tip of the respective sensitive tips comprising:a respective catalyst layer deposited on the sensing tip; andan array of respective vertically aligned multi-walled carbon nanotubes (VAMWCNTs) grown on the respective catalyst layer.20- The electrochemical probe of claim 19 , ...

ANALYTE SENSOR

Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided. 1. An analyte sensing device adapted for implantation into a host's tissue , comprising:a sensor configured to measure an analyte in a host, wherein the sensor comprises a biointerface configured to promote at least one function selected from the group consisting of increasing fluid bulk surrounding at least a portion of the sensor in vivo, increasing bulk fluid flow surrounding at least a portion of the sensor in vivo, and increasing diffusion rates surrounding at least a portion of the sensor in vivo.2. The device of claim 1 , wherein the biointerface comprises a spacer.3. The device of claim 2 , wherein the spacer comprises a mesh.4. The device of claim 2 , wherein the spacer comprises a hydrogel.5. The device of claim 4 , wherein the hydrogel comprises from about 20 wt. % to about 99 wt. % water.6. The device of claim 4 , wherein the hydrogel comprises from about 80 wt. % to about 99 wt. % water.7. The device of claim 2 , wherein the spacer comprises a shedding layer.8. The device of claim 2 , wherein the spacer is a fibrous structure.9. The device of claim 2 , wherein the spacer is a porous polymer membrane.10. The device of claim 2 , wherein the spacer comprises a material selected from the group consisting of polysulfone claim 2 , polytetrafluoroethylene claim 2 , polyvinylidene difluoride claim 2 , polyacrylonitrile claim 2 , silicone claim 2 , polytetrafluoroethylene claim 2 , expanded polytetrafluoroethylene claim 2 , polyethylene-co-tetrafluoroethylene claim 2 , polyolefin claim 2 , polyester claim 2 , polycarbonate claim 2 , biostable polytetrafluoroethylene claim 2 , polyurethane claim 2 , polypropylene claim 2 , ...

BIOIMPEDANCE SENSOR, STYLET, CANNULA AND METHOD FOR MEASURING BIOIMPEDANCE

The objective of the invention is to make the use of a cannula belonging to a bioimpedance sensor easier in a medical procedure after defining the bioimpedance. The bioimpedance sensor () comprises a cannula () and a stylet () moveable in relation to it and is characterized in that: 1300200100200. A bioimpedance sensor () , comprising a cannula () and a stylet () moveable in relation to the cannula () , characterized in that:{'b': 200', '1', '200', '1', '2, 'the cannula () comprises a needle tube (), consisting of or containing electrically conductive material so that the cannula () is configured for use as at least a part of a needle electrode (, );'}{'b': 100', '5', '13', '1', '2', '5, 'the stylet () has a bevelled head and comprises a number of stylet electrodes () surrounded by electrical insulation () in such a manner that the bevelled. head left free from electrical insulation so that the advance of the needle tip can be characterized by measuring the impedance between the needle electrode (, ) and the number of stylet electrodes ();'}{'b': 100', '6', '100', '1', '2', '200, 'the stylet () is additionally equipped with at least one coupling piece () for the electrical coupling of the stylet () to the needle electrode (, ) inside the cannula (),'}{'b': 1', '2', '5', '300', '100, 'whereby the impedance between the needle electrode (, ) and at least one of the stylet electrodes () is measurable inside the bioimpedance sensor () and exclusively through the stylet ().'}230061001221. The bioimpedance sensor () according to claim 1 , wherein a coupling piece () of the stylet () is configured to create a galvanic coupling to the needle electrode ( claim 1 , ) through an adapter () attached or connected to the needle tube ().33002404011. The bioimpedance sensor () according to claim 2 , wherein the adapter () is funnel-shaped claim 2 , preferably comprising at least two successive funnel-shaped structures () of which at-he larger diameter (A) of the funnel-shaped ...

Medical device inserters and processes of inserting and using medical devices

An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices.

Micromanipulation systems and methods

A micromanipulation system includes a micromanipulator that includes a handpiece, and a micromanipulation tool that includes a tool shaft and is operatively connected to the handpiece. The micromanipulator further includes an actuator assembly connected to the micromanipulation tool to provide manual control of the micromanipulation tool, and a force sensing system comprising a force sensor attached to the tool shaft. The force sensing system is configured to provide an output signal that indicates a force imposed on the tool shaft. The micromanipulation system also includes a processor that is in communication with the force sensing system, and is configured to receive the output signal and compensate for forces due to actuation of the micromanipulation tool to determine a force due to interaction of the micromanipulation tool with a region of interest. The processor outputs an indication of at least one of a magnitude and a direction of the determined force.

DEVICE FOR DIAGNOSIS AND INDUCED REGENERATION IN TISSUES BY MEANS OF THERAPEUTIC PERCUTANEOUS ELECTROLYSIS AND ELECTRO-STIMULATION TARGETED VIA BIPOLAR NEEDLE

A device for use in the medical and hospital sector for the diagnosis, induced regeneration of tissue by means of therapeutic percutaneous electrolysis and targeted electro-stimulation based on the use of at least one bipolar needle that includes within a very small area of two electrodes located at the exterior and interior conductor of said bipolar needle, limiting the tissue to be treated within the bevel area of the needle without affecting the surrounding healthy tissue in which said bipolar needle is applied the necessary electrical signals for diagnosing the degree of degeneration and to calculate the necessary electrical charge for treating the damaged tissue while controlling said current in a manner that eliminates the contraindications that currently exist. 12-. (canceled)3. A device for the diagnosis and induced regeneration of tissues comprising: therapeutic percutaneous electrolysis and electro-stimulation targeted through a bipolar needle having the ability for self-diagnosis targeted on the area of damaged tissue to be treated without affecting the surrounding healthy tissue where said means are based on the use of at least one bipolar needle that comprises at its bevel two electrodes located on the exterior and interior conductor of the needle , a control logic allows to apply a sinusoidal signal through at least one AC voltage generator that comprises an oscillator which generates a clock signal for a direct digital synthesiser (DDS) and a D/A converter and also comprises a programmable amplifier stage responsible for amplifying the signal resulting from the digital/analogue conversion and an impedance adaptor for minimising the output error of the programmable amplifier stage , as well as an I/V converter responsible for converting into voltage the current that runs through the tissue , said voltage is amplified by a programmable amplifier stage with impedance adaptor , an A/D converter with low-pass filter for processing the signal and ...

ULTRASOUND PROBE

Provided herein is a probe for ultrasound imaging of tissue. The probe comprises an optical relay having an optically absorbing coating at the distal end of the probe for generating ultrasound from excitation light via the photoacoustic effect, wherein the generated ultrasound propagates as an ultrasound beam into the tissue; and an ultrasound receiver separate from the optical relay. The optical relay is configured to receive as input a time-varying spatial pattern of excitation light at the proximal end of the probe and to transmit the excitation light to the distal end of the probe to illuminate the optically absorbing coating in accordance with said time-varying spatial pattern, thereby generating ultrasound from the excitation light via the photoacoustic effect to propagate as a scanning ultrasound beam into the tissue. The ultrasound receiver is configured to receive reflections of the ultrasound from tissue. Such an ultrasound probe may be incorporated, for example, into a transseptal puncture needle. 1. A probe for ultrasound imaging of tissue , the probe comprising:an optical relay having an optically absorbing coating at the distal end of the probe for generating ultrasound from excitation light via the photoacoustic effect, wherein the generated ultrasound propagates as an ultrasound beam into the tissue; andan ultrasound receiver separate from said optical relay;wherein the optical relay is configured to receive as input a time-varying spatial pattern of excitation light at the proximal end of the probe and to transmit the excitation light to the distal end of the probe to illuminate the optically absorbing coating in accordance with said time-varying spatial pattern, thereby generating ultrasound from the excitation light via the photoacoustic effect to propagate as a scanning ultrasound beam into the tissue;wherein the ultrasound receiver is configured to receive reflections of the ultrasound from tissue.2. The ultrasound probe according to claim 1 , ...

Integrated Optical Neural Probe

In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source. 1. A neural probe , comprising:a semiconductor substrate comprising a back end and one or more elongated shanks for penetrating neural tissue, each elongated shank comprising a proximal end and a distal end;at least one optical source integral to the neural probe for illuminating the neural tissue, wherein the optical source is located proximate the distal end of one or more elongated shanks such that, when the probe is implanted, the neural tissue may be illuminated without the use of an optical waveguide; andone or more microelectrodes located proximate the distal end of one or more of the elongated shanks for monitoring neural activity,wherein the at least one optical source comprises a buffer layer, an active semiconductor layer comprising a III-V semiconductor, and a passivation layer.2. The neural probe of claim 1 , further comprising readout circuitry electrically connected to the one or more microelectrodes.3. The neural probe of claim 2 , wherein the readout circuitry comprises one ...

Systems and methods for processing sensor data

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

CONNECTORS FOR MAKING CONNECTIONS BETWEEN ANALYTE SENSORS AND OTHER DEVICES

Glucose monitoring devices and related systems and methods, the glucose monitoring devices including a sensor electronics unit having a housing and a printed circuit board disposed within the housing, a transcutaneous glucose sensor assembly, and a conductive sensor connector. The printed circuit board includes a first electrical contact, the transcutaneous glucose sensor assembly includes a distal portion having a working electrode and proximal portion having a working-electrode contact in electrical communication with the working electrode, and the conductive sensor connector electrically connects the working-electrode contact with the first electrical contact. Further, the conductive sensor connector extends through a hole in the proximal portion of the transcutaneous glucose sensor assembly and through a hole in the printed circuit board. 124-. (canceled)25. A glucose monitoring device comprising:{'claim-text': ['a housing, and', 'a printed circuit board disposed within the housing and having a plurality of electrical contacts;', {'claim-text': ['a distal portion having a working electrode and', 'a proximal portion having a working-electrode contact in electrical communication with the working electrode; and'], '#text': 'a transcutaneous glucose sensor assembly including:'}, 'a conductive sensor connector configured to electrically connect the working-electrode contact with an electrical contact of the plurality of electrical contacts;'], '#text': 'a sensor electronics unit including'}wherein the conductive sensor connector is further configured to extend through a hole in the proximal portion of the transcutaneous glucose sensor assembly,wherein the conductive sensor connector is in contact with the working-electrode contact on a side of the transcutaneous glucose sensor assembly, the side of the transcutaneous sensor assembly facing a first direction, andwherein the conductive sensor connector is in contact with the electrical contact of the plurality of ...

INSERTION DEVICE

An insertion device is an insertion device configured to insert a medical device into a living body, including a needle portion to which at least a portion of the medical device is adhered and being inserted into the living body together with the adhered medical device; and a movable portion configured to be movable relatively to the needle portion in a direction of insertion of the needle portion, wherein the movable portion moves relatively to the needle portion in the direction of insertion to cut an adhered region between the medical device and the needle portion and separate the medical device and the needle portion. 1. An insertion device for inserting a medical device into a living body , comprising:a needle portion to which at least part of the medical device is adhered and configured to be inserted into the living body together with the adhered medical device; anda movable portion that is movable with respect to the needle portion in a direction of insertion of the needle portion, wherein:the movable portion is configured to move in the direction of insertion with respect to the needle portion to cut an adhered region between the medical device and the needle portion and separate the medical device and the needle portion.2. The insertion device according to claim 1 , wherein the needle portion internally defines a medical device accommodation space that accommodates the medical device.3. The insertion device according to claim 2 , wherein:the needle portion comprises a sidewall portion that defines the medical device accommodation space, andthe medical device is adhered to an inner surface of the sidewall portion.4. The insertion device according to claim 2 , wherein the movable portion has a groove space extending along the direction of insertion that is located within the medical device accommodation space and accommodates the medical device.5. The insertion device according to claim 3 , wherein the movable portion has a groove space extending along the ...

PERCUTANEOUS STIMULATION DEVICE AND METHOD FOR DETECTING COMPARTMENT SYNDROME

A diagnosis device, and more particularly, a compartment syndrome diagnostic device is described herein. The diagnostic device may include a display that renders information associated with stimulation of a motor unit suspected of suffering from compartment syndrome. The diagnostic device may generate a stimulation signal for stimulating the motor unit through an electrode. The device may determine whether the motor unit is at risk for compartment syndrome based on the response of the motor unit to the stimulation. The diagnostic device may also measure pressure of a compartment. The device may determine whether the motor unit is at risk for compartment syndrome based on the measured pressure and the response of the motor unit to the stimulation. 1. A compartment syndrome diagnosis device , comprising:a percutaneous probe comprising an electrode;a lead operatively connected with the percutaneous probe; anda hand-held electrical stimulation device, wherein the hand-held electrical stimulation device generates a stimulus signal intended to elicit a visible and/or palpable muscle contraction of a motor unit of a compartment and the hand-held electrical stimulation device monitors at least one stimulation parameter associated with a stimulation threshold of the motor unit of the compartment,wherein the hand-held electrical stimulation device operatively delivers, based on the stimulation parameter, a stimulation signal to the motor unit via the electrode.2. The device of claim 1 , wherein the percutaneous probe is configured to be at least partially implanted into a tissue region.3. The device of claim 1 , wherein the electrode is configured for delivering unipolar stimulation to the motor unit.4. The device of claim 1 , further comprising a return electrode coupled to the hand-held electrical stimulation device claim 1 , the return electrode configured to provide a return path for the stimulation signal.5. The device of further comprising at least one control device ...

INTRAVASCULAR MEMORY METAL PUNCTURE NEEDLE AND USE THEREOF

This disclosure provides an intravascular memory metal puncture needle and the use thereof. The puncture needle comprises a split-shaped structure capable of opening and closing, as well as a metal spiral hollow tube including a plurality of spiral coils, wherein the split-shaped structure and the metal spiral tube are made of memory metal, and the split-shaped structure is composed of a plurality of tapered petals; when the temperature is T1, the pitch between two adjacent spiral coils in the metal spiral tube is decreased, each of tapered petals in the split-shaped structure is closed; when the temperature is T0, the pitch between two adjacent spiral coils in the metal spiral tube is increased, and each of tapered petals is opened. The puncture needle achieves synergistic effect by matching the metal spiral tube with the split-shaped structure, so that it not only move well in the blood vessels, but also accurately pierce the blood vessel wall, and achieve effective sampling for biopsy. 1. An intravascular memory metal puncture needle , wherein the puncture needle comprises a split-shaped structure capable of opening and closing , as well as a metal spiral hollow tube including a plurality of spiral coils , wherein the split-shaped structure and the metal spiral tube are made of memory metal , and the split-shaped structure is composed of a plurality of tapered petals;when the temperature is T1, the pitch between two adjacent spiral coils in the metal spiral tube is decreased, each of tapered petals in the split-shaped structure is closed, and thus the split-shaped structure exhibits a conical structure, to increase its strength to pierce the blood vessel walls;when the temperature is T0, the pitch between two adjacent spiral coils in the metal spiral tube is increased to enhance flexibility of the device, so that it is able to move in the blood vessels in the body flexibly for a long distance, and each of tapered petals is opened to allow a interventional ...

MULTIFUNCTIONAL INTRAVASCULAR TISSUE PUNCTURE NEEDLE AND USE THEREOF

This disclosure provides a multifunctional intravascular tissue puncture needle and use thereof. The puncture needle comprises a split-shaped structure made of a memory metal and capable of opening and closing, the split-shaped structure is composed of a plurality of tapered petals; when each of tapered petals is closed, the split-shaped structure is a conical structure; when each of tapered petals is opened, the split-shaped structure is a cylindrical structure having a plurality of tapered notches on the wall, and the center of the cylindrical structure is an open cavity structure. The puncture needle can not only move well in the blood vessels, but also accurately pierce the blood vessel wall, and achieve effective sampling for biopsy. 1. A multi-functional intravascular tissue puncture needle , wherein the puncture needle comprises a split-shaped structure made of a memory metal and capable of opening and closing , the split-shaped structure is composed of a plurality of tapered petals;when each of tapered petals is closed, the split-shaped structure is a conical structure;when each of tapered petals is opened, the split-shaped structure is a cylindrical structure having a plurality of tapered notches on the wall, and the center of the cylindrical structure is an open cavity structure.2. The multifunctional intravascular tissue puncture needle according to claim 1 , wherein the tapered petals have the same curvature at each point and are formed by arc-shaped surfaces.3. The multifunctional intravascular tissue puncture needle according to claim 2 , wherein all of the tapered petals are identical in terms of shape and size.4. The multifunctional intravascular tissue puncture needle according to claim 1 , wherein the tapered petal comprise a tail end and a tip end claim 1 , the width thereof is gradually decreased from the tail end to the tip end; when each of tapered petals is closed claim 1 , the diameter of the tail end is larger than that of the tip end.5. The ...

Method for assembling a physiological signal monitoring device

A method for assembling a physiological signal monitoring apparatus on a body surface of a living body is provided, wherein the physiological signal monitoring apparatus is used to measure a physiological signal and includes a sensor module and a transmitter. The method comprises steps of: (a) detaching the bottom cover from the housing to expose the sticker from the bottom opening; (b) while holding the housing, causing the adhesive pad to be attached to the body surface; (c) applying a pressing force on the housing to cause the sensor module to be detached from the implantation module and the signal sensing end to be implanted under the body surface; (d) removing the implanting device while leaving the sensor module on the body surface; and (e) placing the transmitter on the base so that the signal output end is electrically connected to the port.

DRUG DELIVERY METHODS WITH TRACER

Systems and methods for delivering a drug with a tracer or contrast agent are disclosed herein, as are systems and methods that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid. 1. A method of administering a therapy to an anatomy or delivering a drug to a subject , comprising:advancing a convection-enhanced delivery (CED) device having a first fluid lumen and a second fluid lumen into tissue to position an outlet port of the first fluid lumen and an outlet port of the second fluid lumen at a target site within the tissue;delivering a tracer under positive pressure through the first fluid lumen and into the target tissue; andthereafter, delivering a fluid containing the drug under positive pressure through the second fluid lumen and into the previously-delivered tracer.2. The method of claim 1 , wherein the delivery of the fluid containing the drug and its distribution within and around the target site can be visualized during said delivery of the fluid containing the drug.3. The method of claim 1 , further comprising delivering the tracer through the first fluid lumen while delivering the fluid containing the drug through the second fluid lumen.4. The method of claim 1 , wherein delivering the tracer produces a cloud-shaped distribution of tracer within the tissue and delivering the drug displaces the tracer radially outward to expand the ...

Insertion device for a biosensor

An insertion device includes an upper casing, a lower casing and an insertion module. When the lower casing is coupled to the upper casing, an abutment portion of the lower casing limits movement of a casing engaging structure of the upper casing, such that the upper casing cannot move downwardly so as to prevent unintentional insertion operation of the insertion device.

Insertion device for a biosensor

An insertion device includes a cover body, an insertion module. The insertion module is disposed in the cover body, and includes a main body, an insertion seat, a first elastic member, a retraction seat and a second elastic member. When the cover body is depressed, the insertion seat is driven by the first elastic member to perform an automatic-insertion operation and to collapse a limiting structure between the insertion seat and the cover body. A limiting structure between the insertion seat and the retraction seat collapses upon the collapse of the limiting structure between the insertion seat and the cover body, so that the retraction seat is driven by the second elastic member to perform an automatic-retraction operation.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 126-. (canceled)27. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use; and a working electrode comprising a plurality of sensing regions; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor., 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises28. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough.29. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the layer comprises polyurethane.30. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.31. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the reference electrode further comprises silver and silver chloride.32. The transcutaneous electrochemical glucose sensor of claim 27 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor.33. The transcutaneous electrochemical sensor of claim 27 , wherein each of the plurality of sensing regions comprises a membrane.34. The transcutaneous electrochemical sensor of claim 33 , wherein the membrane comprises an enzyme.35. The transcutaneous electrochemical sensor of claim 33 , wherein the ...

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and a planar substrate;', 'a working electrode disposed over at least a portion of the planar substrate;', 'a membrane layer disposed over at least a portion of the working electrode; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor,, 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises22. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer is configured to control a diffusion of glucose therethrough.23. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer comprises polyurethane.24. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.25. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the reference electrode comprises silver and silver chloride.26. The transcutaneous electrochemical glucose sensor of claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby ...

EMG Guidance for Probe Placement, Nearby Tissue Preservation, and Lesion Confirmation

A system and method for locating a target nerve associated with a facet joint via nerve stimulation and monitoring of electrical muscle activity in a multifidus muscle adjacent the target nerve are described. The system includes a probe housed within a cannula and comprising a probe electrode; a recording electrode for monitoring electrical muscle activity in a medial fascicle of the multifidus muscle; a signal generator; and a controller coupled to the probe electrode and recording electrode. The controller delivers a nerve stimulation from the signal generator to the nerve via the probe electrode and monitors electrical muscle activity in the medial fascicle via the recording electrode. The probe's proximity to the nerve is determined by the electrical muscle activity in the medial fascicle elicited as a result of the nerve stimulation, where the controller provides feedback to a user to guide placement of the probe adjacent the nerve. 1. A system for locating a first target nerve associated with a facet joint via nerve stimulation and monitoring of electrical muscle activity in a multifidus muscle adjacent the first target nerve , the multifidus muscle comprising a medial fascicle , an intermediate fascicle , and a lateral fascicle , wherein the system comprises:a first probe comprising an insulated shaft and a first probe electrode located at a distal end of the shaft, wherein the first probe is housed within a first cannula;a first recording electrode for monitoring electrical muscle activity in the medial fascicle of the multifidus muscle, wherein the first recording electrode is configured for placement in the medial fascicle of the multifidus muscle;a signal generator; anda controller coupled to the first probe electrode and the first recording electrode, wherein the controller delivers a first nerve stimulation from the signal generator to the first target nerve via the first probe electrode, wherein the controller monitors electrical muscle activity in the ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility. 117-. (canceled)18. An implantable continuous analyte sensor for measuring an analyte concentration , comprising:a working electrode configured to generate a signal indicative of an analyte concentration; a first domain configured to control a flux of an analyte therethrough, wherein the first domain comprises a blend comprising a first polymer and second polymer, wherein the first polymer is a polymer selected from the group consisting of polyurethane, polyurea, polyurethaneurea, and a silicone-containing polymer, wherein the second polymer is a hydrophilic comb-copolymer; and', 'a second domain comprising an enzyme configured to react with an analyte, wherein at least a portion of the second domain is disposed between the first domain and the working electrode; and, 'a membrane disposed over the working electrode, the membrane comprisingsensor electronics operatively connected to the working electrode, wherein the sensor electronics are configured to process the generated signal to produce a glucose value.19. The implantable continuous analyte sensor of claim 18 , wherein the first polymer is a silicone-containing polyurethane.20. The implantable continuous analyte sensor of claim 18 , wherein the analyte is glucose.21. The implantable continuous analyte sensor of claim 18 , wherein the sensor is configured to be transcutaneously implanted.22. The implantable continuous analyte sensor of claim 18 , wherein the second polymer comprises a poly(ethylene oxide) (PEO) segment.23. The implantable continuous analyte sensor of claim 18 , wherein the second polymer comprises a ...

NEEDLE WITH AN OPTICAL FIBER INTEGRATED IN AN ELONGATED INSERT

A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula. 1. A needle comprising:a hollow shaft having a longitudinal axis and a first bevel formed at a distal end portion of the hollow shaft and with an acute first angle (a) to the longitudinal axis, 'wherein the first angle (a) is smaller than the second angle (b), and', 'an elongated insert having a second bevel formed at a distal end portion of the elongated insert and with an acute second angle (b) to the longitudinal axis,'}an optical fiber, wherein the optical fiber is arranged within the elongated insert and the optical fiber protrudes beyond the surface of the second bevel,wherein the elongated insert is arranged and fixed within the hollow shaft, so that the second bevel and a front surface of the fiber is located within the hollow shaft.2. The needle of claim 1 , wherein the front surface of the optical fiber is formed with a third angle (c) to the longitudinal axis claim 1 , wherein the third angle is greater than the second angle (b).3. The needle of claim 1 , wherein the elongated insert is removably fixed within the hollow shaft.4. The needle of claim 1 , wherein the elongated insert comprises two channels both with an open end at the second bevel of the elongated insert claim 1 , wherein one open end is located more proximally than the other open end claim 1 , and wherein the needle comprises two optical fibers each arranged ...

BLOOD GLUCOSE MEASURING APPARATUS AND OPERATING METHOD OF THE SAME

A blood glucose measuring apparatus and a method of operating the blood glucose measuring apparatus are provided. The blood glucose measuring apparatus includes a cell capsule comprising a reservoir configured to accommodate cells in a suspension, and an electrode configured to receive electric signals from any one or both of a cell in the suspension that is not in contact with the electrode and a cell in the suspension that is in contact with the electrode, and a cell monitoring device configured to monitor the cells. 1. A blood glucose measuring apparatus comprising: a reservoir configured to accommodate cells in a suspension, and', 'an electrode configured to receive electric signals from any one or both of a cell in the suspension that is not in contact with the electrode and a cell in the suspension that is in contact with the electrode; and, 'a cell capsule comprising'}a cell monitoring device configured to monitor the cells.2. The blood glucose measuring apparatus of claim 1 , wherein the cells comprise any one of any combination of pancreatic beta cells claim 1 , a pancreatic beta cell cluster claim 1 , and a pancreatic islet.3. The blood glucose measuring apparatus of claim 1 , wherein the cell capsule comprises:a cell reservoir configured to accommodate the cells;a loading port configured to inject one or more cell of the cells into the cell reservoir;a porous membrane configured to enclose an outer boundary of the cell reservoir; andthe electrode comprises a multi-electrode array (MEA) configured to collect the electric signals generated from the cells.4. The blood glucose measuring apparatus of claim 3 , wherein the MEA is attached to the porous membrane.5. The blood glucose measuring apparatus of claim 3 , wherein electrodes of the MEA are spaced apart from each other and inserted into the porous membrane.6. The blood glucose measuring apparatus of claim 5 , wherein the electrodes of the MEA are in contact with the cell reservoir by passing through the ...

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly. 1a transcutaneous analyte sensor; andsensor electronics operably connectable to the transcutaneous analyte sensor.. A transcutaneous analyte sensor system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/378,491, filed Jul. 16, 2021, which is a continuation of U.S. application Ser. No. 17/200,620, filed Mar. 12, 2021, now U.S. Pat. No. 11,166,657, issued Nov. 9, 2021, which is a continuation of U.S. application Ser. No. 15/387,088, filed Dec. 21, 2016, which, in turn, claims the benefit of U.S. Provisional Application No. 62/272,983, filed Dec. 30, 2015 and U.S. Provisional Application No. 62/412,100, filed Oct. 24, 2016. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.Various embodiments disclosed herein relate to measuring an analyte in a person. Certain embodiments relate to systems and methods for applying a transcutaneous analyte measurement system to a person.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye ...

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly. 1a transcutaneous analyte sensor; andsensor electronics operably connectable to the transcutaneous analyte sensor.. A transcutaneous analyte sensor system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/378,491, filed Jul. 16, 2021, which is a continuation of U.S. application Ser. No. 17/200,620, filed Mar. 12, 2021, now U.S. Pat. No. 11,166,657, issued Nov. 9, 2021, which is a continuation of U.S. application Ser. No. 15/387,088, filed Dec. 21, 2016, which, in turn, claims the benefit of U.S. Provisional Application No. 62/272,983, filed Dec. 30, 2015 and U.S. Provisional Application No. 62/412,100, filed Oct. 24, 2016. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.Various embodiments disclosed herein relate to measuring an analyte in a person. Certain embodiments relate to systems and methods for applying a transcutaneous analyte measurement system to a person.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye ...

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly. 1a transcutaneous analyte sensor; andsensor electronics operably connectable to the transcutaneous analyte sensor.. A transcutaneous analyte sensor system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/378,491, filed Jul. 16, 2021, which is a continuation of U.S. application Ser. No. 17/200,620, filed Mar. 12, 2021, now U.S. Pat. No. 11,166,657, issued Nov. 9, 2021, which is a continuation of U.S. application Ser. No. 15/387,088, filed Dec. 21, 2016, which, in turn, claims the benefit of U.S. Provisional Application No. 62/272,983, filed Dec. 30, 2015 and U.S. Provisional Application No. 62/412,100, filed Oct. 24, 2016. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.Various embodiments disclosed herein relate to measuring an analyte in a person. Certain embodiments relate to systems and methods for applying a transcutaneous analyte measurement system to a person.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye ...

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position. 1. An applicator for applying an on-skin sensor assembly to a skin of a host , the applicator comprising:a first body releasably coupled to a needle;a second body releasably coupled to the first body by a frictional engagement;a spring configured to provide a first force to the first body and second body, the first force driving the first body and second body in a distal direction; andwherein the frictional engagement is configured to be decoupled by a counter force applied to the on-skin sensor assembly in an opposite direction of the first force.2. The applicator of claim 1 , further comprising at least one retention element configured to frictionally couple the second body to the first body.3. The applicator of claim 2 , wherein the at least one retention element is formed integral with the second body.4. The applicator of claim 3 , wherein the at least one retention element is frictionally engaged against a wall of the first body.5. The applicator of claim 4 , wherein the counter force decouples the frictional engagement by displacing the at least one retention element from the wall of the first body.6. The applicator of claim 5 , wherein the wall is a ...

ANALYTE SENSOR

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery. 1. A system for measuring glucose in a host and delivering medication to the host , the system comprising:a catheter configured for insertion into a host and configured to deliver medication to the host, wherein the catheter comprises an exterior surface;a continuous glucose sensor disposed at least partially on the exterior surface of the catheter, wherein the continuous glucose sensor is configured to generate sensor data indicative of glucose concentration; andsensor electronics operatively connected to the continuous glucose sensor, wherein the sensor electronics are configured to determine a glucose concentration.2. The system of claim 1 , wherein the continuous glucose sensor is integrally formed on the exterior surface of the catheter.3. The system of claim 1 , wherein the continuous glucose sensor is electroplated onto the exterior surface of the catheter.4. The system of claim 1 , wherein the continuous glucose sensor comprises a working electrode and a membrane system covering at least a portion of the working electrode.5. The system of claim 1 , wherein the working electrode comprises an exposed electroactive surface.6. The system of claim 1 , wherein the catheter is configured to be operatively connected to an infusion pump.7. The system of claim 1 , wherein in response to sensor data received from the continuous glucose sensor claim 1 , the sensor electronics are configured to communicate a therapy recommendation to the infusion pump claim 1 , wherein the therapy recommendation comprises information relating to insulin amount.8. The system of claim 1 , wherein the continuous glucose sensor is configured to be used subcutaneously.9. The system ...

Probe

A probe, such as a spectroscopic probe, for enabling a fluid or tissue sample to be tested in situ. The probe includes a conduit, such as a hypodermic needle, that can be inserted into a test subject and a wave coupling arranged to direct electromagnetic radiation, such as light, from an energy source to the sample and/or from the sample to a receiver for analysis. The receiver may comprise a Raman spectroscope. The probe may include a carriage that can be used to move at least some of the optical coupling towards and away from the insertion tip of the conduit. The probe may include a pressure modifier that can be used to draw fluid into or expel fluid from the conduit.

TRANSCUTANEOUS ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A transcutaneous system for measuring an analyte concentration in a host , the system comprising:a sensor adapted for transcutaneous placement through a skin of a host, the sensor comprising a first end and a second end;a housing configured to support the sensor during a period of transcutaneous insertion; andan applicator comprising a needle configured for inserting the sensor into the skin of the host; wherein the needle is capable of inserting the first end of sensor into the host, sliding back over the second end of the sensor, and wherein the needle is configured to be released from the housing during the period of continuous transcutaneous insertion, wherein the first end and second end of the sensor are sized to fully reside within the needle.2. The system of claim 1 , further comprising sensor electronics configured to releasably attach to the housing during the period of transcutaneous insertion.3. The system of claim 1 , wherein the time period of transcutaneous insertion is at least about 3 days.4. A transcutaneous system for measuring an analyte concentration in a host claim 1 , the system comprising:a non-planar sensor adapted for transcutaneous placement through a skin of a host, the sensor comprising a first end and a second end; andan applicator comprising a needle configured for inserting the sensor into the skin of the host, wherein the system is configured such that the needle is capable of inserting the first end of sensor into the host, sliding back over the second end of the sensor, and thereby releasing the sensor from the needle, wherein a portion of the second end of the sensor is configured to provide connectivity between the sensor and sensor electronics.5. The system of claim 4 , wherein the non-planar sensor ...

Internal optical spectroscope and method for real time in-situ diagnosis in living cells

The present application relates to an internal optical spectroscope comprising: a needle sleeve insertable into and removable from targeted living tissue; a shaft housed by the needle sleeve including at least one v-shaped trough including an aft side and a next-to-aft side; a light source comprising variable light wave lengths of both visible and near infrared light; at least one light transmission fiber comprising a transmitting end; at least one light detector fiber comprising a receptive end; and data processor. The present application also relates to a method of performing an optical biopsy in situ.

STETHOSCOPE DIGITAL ADAPTER CONFIGURED TO ENHANCE USABILITY OF AN ACOUSTIC STETHOSCOPE

Disclosed is a stethoscope digital adapter configured to enhance usability of an acoustic stethoscope. The stethoscope digital adapter may include a body comprising an exterior shell configured to form an interior space. Further, the body may include a microphone disposed in the interior space. Further, the microphone may be configured to convert an acoustic wave into an electrical sound signal. Further, the body may include an electrical interconnect electrically coupled to the microphone. Further, the electrical interconnect may be configured to be electrically coupled with an external electronic device configured to process the electrical sound signal. Further, the body may include a conduit attached to the exterior shell. Further, the stethoscope digital adapter may include a fastener attached to the body. 1. A stethoscope digital adapter configured to enhance usability of an acoustic stethoscope , the stethoscope digital adapter comprising: an exterior shell configured to form an interior space;', 'a microphone disposed in the interior space, wherein the microphone is configured to convert an acoustic wave into an electrical sound signal;', 'an electrical interconnect electrically coupled to the microphone, wherein the electrical interconnect is configured to be electrically coupled with an external electronic device configured to process the electrical sound signal, wherein a part of the electrical interconnect is disposed on the exterior shell; and', 'a conduit attached to the exterior shell, wherein the conduit comprises a first conduit opening and a second conduit opening and a conduit channel fluidly connecting the first conduit opening to the second conduit opening, wherein the first conduit opening is acoustically coupled to the microphone, wherein the second conduit opening is configured to be acoustically coupled to a tube of the acoustic stethoscope; and, 'a body comprisinga fastener attached to the body, wherein the fastener is configured to ...

Subcutaneous sensor inserter and method

An inserter assembly for continuous glucose monitoring with medication delivery capability where the assembly has a deployment button containing a needle deployment mechanism having a sharp held in a pre-release position, a housing body in which the deployment button is movably received within a top end of the housing body, the housing body having a sensor deployment assembly containing a lumen and a sensor disposed within the lumen and extending out of the lumen to a circuit board that is part of the sensor deployment assembly, the sensor deployment assembly matingly connected to the sharp where the sharp extends beyond the sensor deployment assembly and contains the sensor not fixedly attached to the sharp, and a sensor housing releasably received within a lower end of the housing body, the sharp extending into a sensor deployment assembly recess within the sensor housing and directly above a sensor opening in a bottom of the sensor housing.

DEVICE FOR MEASURING URINARY DETRUSOR PRESSURE

The present invention relates to a device for measuring bladder pressure, comprising: a measurement rod inserted into the abdomen of a user to measure both abdomen pressure and bladder pressure; and a body unit provided to be worn on the waist of the user and electrically connected to the measurement rod so as to calculate and store urinary detrusor pressure measured by subtracting a measurement abdomen pressure from a measurement bladder pressure measured by the measurement rod. 1. A device for measuring bladder pressure , comprising:a measurement rod configured to be inserted into an abdomen of a user to measure both abdominal pressure and bladder pressure; anda body unit configured to be worn on a waist of the user, and be electrically connected with the measurement rod, to calculate and store detrusor pressure obtained by subtracting the measured abdominal pressure from the bladder pressure measured by the measurement rod.2. The device of claim 1 , further comprising a guide tube configured to penetrate and be inserted into the abdomen of the user claim 1 , and receive the measurement rod within it claim 1 , to guide the measurement rod.3. The device of claim 2 , wherein the body unit comprises:a body having a display unit and an input unit;an adapter provided on the backside of the body to come into contact with the abdomen of the user, to be electrically connected with the measurement rod; anda belt coupled to both sides of the body, and configured to be worn on the waist of the user.4. The device of claim 3 , further comprising a wireless control unit configured to be separate from the body unit claim 3 , to enable an inputting person to input signals using buttons.5. The device of claim 3 , wherein the measurement rod comprises:a rod body having a predetermined length;a bladder pressure measurement unit configured to be provided at a lower end of the rod body, to measure the bladder pressure of the user;an abdominal pressure measurement unit configured to be ...

Biopsy Method and Apparatus

A tissue sampling apparatus and method obtain a sample of tissue from a selected site and place a hemostatic plug at the selected site. The apparatus includes an external needle and an internal needle within the external needle. A chamber in the internal needle is divided by a divider member into a plug compartment for receiving a hemostatic plug, and a sample compartment for receiving a tissue sample. The divider member is resiliently biased into the plug compartment and the internal needle is movable relative to the external needle for admitting the hemostatic plug into the plug compartment and displacing the divider member into the sample compartment, and then closing the chamber. The apparatus then is advanced to the selected site where relative movement between the internal and external needles opens the chamber, allowing the divider member to expel the hemostatic plug from the plug compartment, and admitting a tissue sample into the sample compartment. Subsequent relative movement between the internal and external needles cuts the tissue sample from the surrounding tissue for removal from the selected site upon removal of the apparatus, while the expelled hemostatic plug remains at the site. 1. A tissue sampling apparatus for obtaining a sample of tissue from a selected site and for placing a hemostatic plug at the selected site , the apparatus comprising:an external needle having an internal passage and a tissue-cutting edge;an internal needle within the internal passage, the internal needle terminating at a forward tissue-penetrating tip and having a chamber adjacent the tissue-penetrating tip, the internal needle and the external needle being selectively movable relative to one another between a first position, wherein the chamber is closed by the external needle, and a second position, wherein the chamber is open;a divider member dividing the chamber into opposite compartments, including a plug compartment for receiving a hemostatic plug, and a sample ...