УРОЛОГИЧЕСКОЕ УСТРОЙСТВО

Изобретение относится к медицине, а именно к способу расположения урологического устройства в мочевом пузыре пациента. Причем урологическое устройство содержит урологический клапан и стержень, поддерживающий клапан, при этом способ содержит этап расположения стержня, поддерживающего клапан, в мочеиспускательном канале пациента, и этап расположения урологического клапана в мочевом пузыре пациента, при этом способ дополнительно содержит этап продвижения катетера, включающего удерживаемые в нем в сжатом состоянии урологический клапан и стержень, поддерживающий клапан, и этап разворачивания устройства из катетера, причем во время разворачивания устройство расширяется до развернутого состояния, и катетер вытягивается для закрепления проксимального конца устройства. 5 з.п. ф-лы,105 ил.

Искусственный сфинктер мочевого пузыря

Полезная модель относится к хирургическим устройствам и может быть использована для устранения тяжелой степени недержания мочи у пациентов.Искусственный сфинктер мочевого пузыря, имеющий корпус с магнитной системой сдавливания уретры, отличающийся тем, что устройство состоит из выполненных из биологически инертного эластичного материала полых корпуса и резервуара, соединенных друг с другом посредством полой трубки; корпус имеет боковые лепестки с отверстиями; в передней части корпус имеет лапку с постоянным магнитом, который расположен в углублении на наружной поверхности лапки; задняя часть корпуса имеет снаружи углубление, в котором расположена пластина из ферромагнитного материала; постоянный магнит и пластина имеют биологически инертное покрытие; наружные размеры углублений на лапке и задней части корпуса меньше их внутренних размеров; с внутренней стороны передняя и задняя части корпуса имеют седлообразные углубления, к которым прилежит уретра; в резервуаре находится стерильный физиологический раствор. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 169 016 U1 (51) МПК A61F 2/04 (2013.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21)(22) Заявка: 2016123541, 14.06.2016 (24) Дата начала отсчета срока действия патента: 14.06.2016 01.03.2017 Приоритет(ы): (22) Дата подачи заявки: 14.06.2016 Адрес для переписки: 443099, г. Самара, ул. Чапаевская, 89, ФГБОУ ВО СамГМУ Минздрава России (56) Список документов, цитированных в отчете о поиске: RU 140189 U1, 27.04.2014. RU 81066 U1, 10.03.2009. SU 166306 A1, 23.07.1991. WO 2013041112 A1, 28.03.2013. U 1 1 6 9 0 1 6 U 1 (54) Искусственный сфинктер мочевого пузыря R U 1 6 9 0 1 6 (45) Опубликовано: 01.03.2017 Бюл. № 7 (73) Патентообладатель(и): Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СамГМУ Минздрава России) ...

УРОЛОГИЧЕСКОЕ УСТРОЙСТВО

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2016 138 311 A (51) МПК A61M 25/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2016138311, 03.11.2011 (71) Заявитель(и): КОЛОПЛАСТ А/С (DK) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): БЕХАН Ниалл (IE) 35 R U (54) УРОЛОГИЧЕСКОЕ УСТРОЙСТВО (57) Формула изобретения 1. Способ расположения урологического устройства в мочевом пузыре пациента, причем урологическое устройство содержит урологический клапан и стержень, поддерживающий клапан, при этом способ содержит этап расположения стержня, поддерживающего клапан, в мочеиспускательном канале пациента, и этап расположения урологического клапана в мочевом пузыре пациента, при этом способ дополнительно содержит этап продвижения катетера, включающего удерживаемые в нем в сжатом состоянии урологический клапан и стержень, поддерживающий клапан, и этап разворачивания устройства из катетера. 2. Способ по п. 1, в котором во время этапа разворачивания урологическое устройство расширяется до развернутого состояния, при этом способ дополнительно включает в себя этап вытягивания катетера из мочеиспускательного канала. 3. Способ по п. 1, в котором урологический клапан автоматически переходит из закрытой конфигурации в открытую конфигурацию в ответ на заранее заданное гидродинамическое давление, прикладываемое в течение заранее заданного времени. 4. Способ по п. 1, в котором стержень, поддерживающий клапан, содержит по существу трубчатую опору для прохождения по меньшей мере частично через мочеиспускательный канал, при этом клапан расположен на одном конце опоры. 5. Способ по п. 1, в котором урологическое устройство содержит фиксатор для фиксации в мочевом пузыре, позволяющем располагать клапан в мочевом пузыре пациента. Стр.: 1 A 2 0 1 6 1 3 8 3 1 1 A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" 2 0 1 6 1 3 8 3 1 1 (43) Дата публикации заявки: 13.12.2018 ...

Schichtstruktur zur Abgabe mindestens eines Wirkstoffs

Schichtstruktur zur Abgabe mindestens eines Wirkstoffs, wobei die Schichtstruktur aufweist: ein Trägersubstrat (100), eine Mehrzahl von Wirkstoffbereichen (101), die voneinander beabstandet auf dem Trägersubstrat (100) aufgebracht sind und den mindestens einen Wirkstoff enthalten, wobei jeder der Wirkstoffbereiche (101) rundum von nicht wirkstoffbelegten Zwischenbereichen (102) des Trägersubstrats umgeben ist, eine semipermeable Deckschicht (103), die auf das Trägersubstrat (100) und die darauf befindlichen Wirkstoffbereiche (101) aufgebracht ist und sowohl die Wirkstoffbereiche (101) als auch die nicht wirkstoffbelegten Zwischenbereiche (102) des Trägersubstrats überdeckt, wobei die semipermeable Deckschicht (103) in den nicht wirkstoffbelegten Zwischenbereichen (102) unmittelbar oder mittelbar auf dem Trägersubstrat (100) anhaftet, wobei jeder der Wirkstoffbereiche (101) rundum seitlich und von oben her von der semipermeablen Deckschicht (103) umschlossen ist, so dass sich Wirkstoffdepots ...

Improvements relating to decellularisation of tissue matrices for bladder implantation

low compliance Hemisphere for bladder expansion in patients with

Improved absorbable patch, in reinforced PGA, for the replacement of a portion of bladder wall following partial cystectomy

Patch for replacing a portion of bladder wall

Reabsorbable concave plate (scaffold) for the replacement of a portion of bladder wall following partial cystectomy

Patch for replacing a portion of bladder wall

Reabsorbable concave plate (scaffold) for the replacement of a portion of bladder wall following partial cystectomy.

Improved absorbable patch, in reinforced PGA, for the replacement of a portion of bladder wall following partial cystectomy

low compliance Hemisphere for bladder expansion in patients with

Improved absorbable cap for bladder enlargement inpatients with low compliance or for the replacement of a vast portion of bladder following bilharzia

Patch for replacing a portion of bladder wall

Reabsorbable concave plate (scaffold) for the replacement of a portion of bladder wall following partial cystectomy.

Improved absorbable cap for bladder enlargement inpatients with low compliance or for the replacement of a vast portion of bladder following bilharzia

Reabsorbable concave plate (scaffold) for the replacement of a portion of bladder wall following partial cystectomy.

Improved absorbable patch, in reinforced PGA, for the replacement of a portion of bladder wall following partial cystectomy

Improved absorbable cap for bladder enlargement inpatients with low compliance or for the replacement of a vast portion of bladder following bilharzia

BISTABILE STRUCTURE OF FEATHER/SPRING FOR A STENT

IN BODY FABRIC INJECT-CASH COMPOSITIONS

Controlled extension stent

The present disclosure relates generally to controlled extension medical stents, and more particularly to controlled extension devices positioned in the body to stent the ureter and facilitate drainage from the kidney to the bladder. The stent 302 being formed of a plurality of filaments 302 wound in groups of coils defining a lumen 306 having a non-extended state in which substantial contact between adjacent groups is prensent and a extended state in which the adjacent groups are separated.

A dilating device for prostatic urethra

There is disclosed a dilating device for a prostatic urethra, the dilating device comprising: at least two dilating means of the prostate urethra configured to laterally expand to a normally open configuration within the prostatic urethra, to exert a lateral outwards force that dilates the prostatic urethra; a connecting ridge connecting said at least two dilating means; wherein said dilating means include two distal protrusions configured to impinge against postero lateral sides of a bladder neck in said normally-open configuration and wherein said distal protrusions protrude distally beyond a distal end of a central portion of the dilating device.

Method of producing biomaterials

IMPLANTABLE PRESSURE ATTENUATION DEVICE

Smooth muscle cell constructs

The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.

Implantable device with intravesical tolerability and methods of treatment

Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1 N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.

Orthotopic artificial bladder endoprosthesis

An orthotopic artificial bladder endoprosthesis comprises a casing (2) made of a PGA fiber fabric; said casing (2) having two first connectors (3) for the connection with the ureters of a patient and a further connector (4) for the connection with the urethra of a patient; an inflatable element (5) inserted in said casing (2); said inflatable element (5) being switchable between an inflated configuration, in which it supports and maintains in position the casing (2), and a deflated configuration.

Improvements Relating to Decellularisation of Tissue Matrices for Bladder Implantation

The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the 5 bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material, The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.

IMPLANTABLE DEVICE FOR INTERNAL URINARY CONTROL

The present invention relates to an implantable apparatus for obtaining urinary control and emptying of the urinary bladder, thereby preventing from or treating involuntary urinary retention. In general terms, the apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient for discharging urine, and a control device for controlling the volume of the expandable member. The control device is adapted to be connected to the expandable member through the wall of the urinary bladder.

IMPLANTABLE DEVICE FOR INTERNAL URINARY CONTROL

UROLOGICAL DEVICE COMPRISING EXTENDING LEAFLET

This invention relates to a urological device comprising: a valve support stem, a bladder retainer, and a urological valve disposed in the bladder retainer, the urological valve including a leaflet, wherein the leaflet of the urological valve has a closed configuration adapted to prevent a flow of urine through the valve support stem and the leaflet of the urological valve is adapted to respond to a pressure and move to an open configuration adapted to allow a flow of urine through the valve support stem; wherein the leaflet extends from the interior surface of the bladder retainer to a top proximal end of the device. This device is used for treatment of urinary incontinence in patients with prostate cancer.

IMPROVEMENTS RELATING TO DECELLULARISATION OF TISSUE MATRICES FOR BLADDER IMPLANTATION

The invention provides an improved method of producing a natural, acellul ar matrix scaffold for subsequent use in tissue-engineered replacement of ti ssues such as the bladder. Decellularisation is carried out on an expanded o r distended bladder and the product retains the strength and compliance of n atural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in v itro.

ARTIFICIAL IMPLANT INTENDED TO REPLACE THE HUMAN URINARY AND EXCRETORY ORGANS

L'invention vise à réaliser un implant ne nécessitant pas d'intervention chirurgicale lourde lors de sa mise en place ou lors du remplacement partiel d'un de ses éléments, tout en permettant un maintien en place de la prothèse à long terme. Pour cela, l'implant de la présente invention est un remplacement intégral de l'appareil urinaire afin d'éviter tout anastomose, et présente une structure à double couche (7, 8) pour les éléments artificiels de substitution: des éléments tubulaires (1, 3) pour les uretères et l'urètre, un réservoir (2) pour la vessie et un sphincter urétral artificiel (4). Les éléments tubulaires artificiels des urètres (1) sont liés au réservoir (2) par des connexions mécaniques (5) et ces éléments (1 à 3) sont composés et conformés pour permettre leur passage entre un état aplati à vide et un état expansé. Les deux couches (7, 8) sont solidaires pour composer les éléments tubulaires (1, 3) et forment respectivement une coque externe, suffisamment flexible pour être ...

ORTHOTOPIC ARTIFICIAL ENDOPROSTHESIS URINARY BLADDER

ORTHOTOPIC ARTIFICIAL ENDOPROSTHESIS URINARY BLADDER

ORTHOTOPIC PROSTHESIS OF ARTIFICIAL BLADDER

IMPROVED ABSORBABLE CAP FOR BLADDER ENLARGEMENT IN PATIENTS WITH LOW COMPLIANCE OR FOR THE REPLACEMENT OF A VAST PORTION OF BLADDER FOLLOWING BILHARZIA

IMPROVED ABSORBABLE CAP FOR EXPANSION OF URINARY BLADDER IN PATIENTS WITH LOW LEVEL OF ELASTICITY OR FOR REPLACEMENT OF EXTENSIVE PART OF URINARY BLADDER AFTER BILGARTsIOZA

IMPROVED ABSORBABLE CAP FOR BLADDER ENLARGEMENT IN PATIENTS WITH LOW COMPLIANCE OR FOR THE REPLACEMENT OF A VAST PORTION OF BLADDER FOLLOWING BILHARZIA

Organ prosthesis mrr. from preform - with application of gel-forming sol and curable flexible material

ARTIFICIAL IMPLANT INTENDS FOR the REPLACEMENT OF URINARY APPARATUS EXCRETEUR AT the Human being

VESICAL PROSTHESIS

PATCH TO REPLACE A PORTION OF WALL OF THE BLADDER

Un parche para reemplazar una porcion de pared de la vejiga. El parche se fabrica con un material de l mina multicapa que comprende: una capa de base intermedia (2), que se fabrica de un material sintetico blando y el stico, que tiene la capacidad de asegurar una deformacion correcta de la vejiga a la cual se le aplica el parche, y una capa de recubrimiento interno (4) de un biomaterial altamente biocompatible que tiene la capacidad de no deteriorarse al estar en contacto con la orina y una capa de recubrimiento externo (5) de un biomaterial altamente biocompatible que tiene la capacidad de prevenir la fusion con los tejidos internos del paciente.

IMPLANTABLE DEVICE FOR INTERNAL URINARY CONTROL

CELL-SCAFFOLD CONSTRUCTS

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

IMPLANTABLE MEDICAL DEVICE WITH PHARMOCOLOGICALLY ACTIVE INGREDIENT

An implantable medical device comprising an inner region and an outer region positioned over at least a portion of the inner region and in contact with a surface of the inner region. The durometer of the inner region is greater than the durometer of the outer region and a pharmacologically active ingredient is present in at least a portion of the inner region or the outer region.

Prosthetic bladder and method of prosthesis implantation

IMPLANTABLE DEVICE FOR INTERNAL URINARY CONTROL

The present invention relates to an implantable apparatus for obtaining urinary control and emptying of the urinary bladder, thereby preventing from or treating involuntary urinary retention. In general terms, the apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient for discharging urine, and a control device for controlling the volume of the expandable member. The control device is adapted to be connected to the expandable member through the wall of the urinary bladder.

DEVICE AND METHOD FOR REPAIR OF UROLOGICAL STRUCTURES

A tissue engineering construct made from a nonwoven fabric. The fabric is made from first and second staple fibers. The first staple fibers are made from a first biocompatible, bioabsorbable material, and the second staple fibers are made from a second biocompatible, bioabsorbable material. The first material has a melting temperature lower than the second material. The fabric is formed into a three-dimensional construct suitable for the repair of urinary tract structures.

ЗАПЛАТКА ДЛЯ ЗАМЕЩЕНИЯ УЧАСТКА СТЕНКИ МОЧЕВОГО ПУЗЫРЯ ПОСЛЕ ЧАСТИЧНОЙ ЦИСТЭКТОМИИ

Группа изобретений относится к медицине. Заплатка включает многослойную мембрану из мягкого силикона с толщиной около 600 микрон с тем, чтобы обладать достаточной эластичностью для способности выдерживать дилатации из-за расширения и опорожнения мочевого пузыря. Способ получения вышеуказанной заплатки включает формирование многослойной мембраны из мягкого силикона с толщиной около 600 микрон с тем, чтобы она была достаточно эластичной для способности выдерживать дилатацию из-за расширения и опорожнения мочевого пузыря. Группа изобретений обеспечивает надежность, продление сроков службы и легкость изготовления. 2 н. и 13 з.п. ф-лы, 7 ил.

УРОЛОГИЧЕСКОЕ УСТРОЙСТВО

Изобретение относится к медицинской технике, а именно к урологическим устройствам. Урологическое устройство, содержащее клапан, причем корпус клапана выполнен из полимерного материала и имеет внешнюю опорную область с опорным кольцом и по меньшей мере тремя створками клапана, и область основного корпуса, проходящую между опорным кольцом и створками корпуса, при этом створки клапана проходят внутрь и оканчиваются у концевых поверхностей, при этом каждая створка клапана имеет ножки, причем клапан имеет первую конфигурацию, когда клапан закрыт и ножки соединены, и клапан имеет вторую конфигурацию, когда створки клапана открыты так, что ножки створок открыты и расположены на расстоянии друг от друга в ответ на усилие, что позволяет пропускать поток через клапан, причем клапан выполнен с возможностью автоматического перехода из закрытого состояния в открытое состояние в ответ на заданное гидродинамическое давление, прикладываемое в течение заданного времени. 8 з.п. ф-лы, 105 ил.

УРОЛОГИЧЕСКОЕ УСТРОЙСТВО

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2016 138 299 A (51) МПК A61M 25/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2016138299, 03.11.2011 (71) Заявитель(и): КОЛОПЛАСТ А/С (DK) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): БЕХАН Ниалл (IE) 35 R U (54) УРОЛОГИЧЕСКОЕ УСТРОЙСТВО (57) Формула изобретения 1. Урологическое устройство, содержащее клапан, причем корпус клапана выполнен из полимерного материала и имеет внешнюю опорную область с опорным кольцом и по меньшей мере тремя створками клапана, и область основного корпуса, проходящую между опорным кольцом и створками корпуса, при этом створки клапана проходят внутрь и оканчиваются у концевых поверхностях, при этом каждая створка клапана имеет ножки, причем клапан имеет первую конфигурацию, когда клапан закрыт и ножки соединены, и клапан имеет вторую конфигурацию, когда створки клапана открыты так, что ножки створок открыты и расположены на расстоянии друг от друга в ответ на усилие, что позволяет пропускать поток через клапан. 2. Устройство по п. 1, в котором клапан выворачивается наружу при переходе из первой конфигурации во вторую конфигурацию. 3. Устройство по п. 1 или 2, в котором основной корпус клапана имеет вогнутую форму. 4. Устройство по п. 1, в котором при приложении усилия в обратном направлении к створкам створки клапана выполнены с возможностью отталкивания друг от друга, при этом корпус клапана выполнен с возможностью выворачивания, когда усилие превышает заданное значение. 5. Устройство по п. 4, в котором основной корпус клапана и створки клапана проходят вниз в обратном направлении, когда клапан полностью открыт. 6. Устройство по п. 4 или 5, в котором основной корпус выполнен с возможностью Стр.: 1 A 2 0 1 6 1 3 8 2 9 9 A Адрес для переписки: 129090, Москва, ул. Большая Спасская, д. 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" 2 0 1 6 1 3 8 2 9 9 (43) Дата публикации заявки: 12.12.2018 Бюл. № R U 03.11. ...

ИСКУССТВЕННЫЙ ОРТОТОПИЧЕСКИЙ ЭНДОПРОТЕЗ МОЧЕВОГО ПУЗЫРЯ

... 1. Искусственный ортотопический эндопротез мочевого пузыря, отличающийся тем, что содержит первый участок (2), выполненный с возможностью соединения с уретрой пациента, и второй участок (3), выполненный с возможностью соединения с мочеточниками упомянутого пациента;причем упомянутый первый участок (2) содержит сжимающийся кожух (4), изготовленный из многослойной силиконовой мембраны, имеющей внешнюю поверхность (4а) и внутреннюю поверхность (4b), которые обе покрыты пиролитическим турбостратическим углеродом;упомянутый второй участок (3) содержит рассасывающуюся крышку (7), содержащую полотно (8) из волокон PGA, и раму (9), соединенную с упомянутой крышкой (7), изготовленной с использованием сополимер PGA/PLA; причем упомянутый кожух (4) и упомянутая крышка (7) соединяются вместе вдоль их соответствующих границ (4c, 7a), чтобы образовать оболочку.2. Эндопротез по п. 1, отличающийся тем, что кожух (4) содержит полоску (12), выступающую из упомянутого края (4с) кожуха (4) и изготовленную ...

VALVE BLISTER PROSTHESIS

ARTIFICIAL IMPLANT FOR REPLACING THE HUMAN URINE ELIMINATION ORGAN

ARTIFICIAL URINE DERIVATIVE SYSTEM

METHODS FOR PRODUCTION OF ELASTIN, ON ELASTIN BASED BIOLOGICAL MATERIALS AND TROPOELASTIN MATERIALS

A urological device

A urological device (800, 810, 830, 850, 860, 870, 900, 910, 920) comprises a urological valve (802, 803, 812, 861, 901), for location in the bladder of a patient and a valve support stem (801, 813, 863, 902), for location in the urethra of a patient. The valve has a normally closed configuration to prevent flow from the bladder and an open configuration for fluid flow through the valve. The valve is automatically movable from the closed configuration to the open configuration in response to a pre -set hydrodynamic pressure applied for a pre-set time. In one case the valve has a plurality of valve leaflets with a region of co-aption between the valve leaflets. In the normally closed configuration the valve leaflets are engaged at the region of co-aption and in the open configuration the leaflets are separated at the co-aption region for fluid flow through the valve.

Orthotopic artificial bladder endoprosthesis

An orthotopic artificial bladder endoprosthesis comprises a casing (2) made of a PGA fiber fabric; said casing (2) having two first connectors (3) for the connection with the ureters of a patient and a second connector (4) for the connection with the urethra of a patient; a support element (5) being inserted in said casing (2); said support element (5) being switchable between an extended configuration, in which it supports and maintains in position the casing (2), and a retracted configuration.

A dilating device for prostatic urethra

There is disclosed a dilating device for a prostatic urethra, the dilating device comprising: at least two dilating means of the prostate urethra configured to laterally expand to a normally open configuration within the prostatic urethra, to exert a lateral outwards force that dilates the prostatic urethra; a connecting ridge connecting said at least two dilating means; wherein said dilating means include two distal protrusions configured to impinge against postero lateral sides of a bladder neck in said normally-open configuration and wherein said distal protrusions protrude distally beyond a distal end of a central portion of the dilating device.

MEDICAL DEVICES INCORPORATING COLLAGEN INHIBITORS

Provided herein are implantable or insertable biomedical devices comprisi ng a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the dev ice is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for pre venting adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the su bstrate.

SCAFFOLDS FOR ORGAN RECONSTRUCTION AND AUGMENTATION

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

IMPROVED ABSORBABLE CAP FOR BLADDER ENLARGEMENT IN PATIENTS WITH LOW COMPLIANCE OR FOR THE REPLACEMENT OF A VAST PORTION OF BLADDER FOLLOWING BILHARZIA

A description is given of a domed cap (100) for the enlargement of an atrophied bladder (200), in biocompatible and absorbable material comprising a textile (1) made with yarns or with monofilaments deriving from PGA fibres, characterised in that said textile (1) is supported by a star-shaped frame with domed profile, formed by a plurality of radial strips (3) manufactured by injection of a PGA/PLA copolymer, said cap (100) being suitable for growing thereon autologous fibrous capsule cells, generated by the process of tissue reconstruction, after its insertion inside the patient.

TISSUE INJECTABLE COMPOSITION AND METHOD OF USE

An improved biocompatible composition consisting of physiologically stable microparticles carried in a lubricative suspension, solution, other fluid or gel is presented. The composition is intended to be delivered into the body through a small-bore needle, cannula, or catheter and to a tissue site for the purpose of augmenting the tissue site and surrounding area, thereby con-ectlng a defect, filling a void, or strengthening the support structures of the tissue. The particles are a hard, metallic substance and are carbon-coated.

IMPROVED ABSORBABLE PATCH, IN REINFORCED PGA, FOR THE REPLACEMENT OF A PORTION OF BLADDER WALL FOLLOWING PARTIAL CYSTECTOMY

HEMISPHERE FOR BLADDER EXPANSION IN PATIENTS WITH LOW COMPLIANCE

IMPROVED ABSORBABLE PATCH, IN REINFORCED POLYGLYCOLIC ACID (PGA), FOR THE REPLACEMENT OF A PORTION OF BLADDER WALL FOLLOWING PARTIAL CYSTECTOMY

IMPROVED RASSASYVAYuShchAYaSYa FILM OF AMPLIFIED PGA FOR REPLACEMENT OF PART OF WALL OF URINARY BLADDER AFTER PARTIAL CYSTECTOMY

ORTHOTOPIC ARTIFICIAL ENDOPROSTHESIS URINARY BLADDER

CELL-SCAFFOLD CONSTRUCTS

BLADDER PROSTHESIS

Bladder prosthesis, consisting of a liquid container (2) with at least one entry (3-4) and at least one exit (5), characterized in that the liquid container (2) has a shape which is anatomically adapted to the shape of the pelvis.

HEMISPHERE FOR BLADDER EXPANSION IN PATIENTS WITH LOW COMPLIANCE

A description is given of a device for the expansion of an atrophied bladder formed by a hemisphere (100,200), as a single piece, in biocompatible material characterised in that said material is selected from polylactic acid (PLA) and silicone coated with pyrolytic turbostratic carbon or with amorphous diamond-like carbon.

IMPLANTABLE DEVICE FOR INTERNAL URINARY CONTROL

An apparatus for treating urinary retention of a patient by discharging urine from the urinary bladder. The apparatus comprises an expandable member, adapted to be implanted inside the urinary bladder of a patient, for discharging urine from the urinary bladder as a result of its expansion in volume, an implantable control device for controlling the volume of the expandable member, and an external energy transmission device for wireless transmission of energy from the outside of the patient's body to the inside of the patient's body configured to operate the expandable member and other energy consuming implantable parts of the apparatus. 185.-. (canceled)86. An apparatus for treating urinary retention of a patient by discharging urine from the urinary bladder , characterized in that it comprises:an expandable member, adapted to be implanted inside the urinary bladder of a patient, for discharging urine from the urinary bladder as a result of its expansion in volume,an implantable control device for controlling the volume of the expandable member, andan external energy transmission device for wireless transmission of energy from the outside of the patient's body to the inside of the patient's body configured to operate the expandable member and other energy consuming implantable parts of the apparatus.87. An apparatus according to claim 86 , wherein the control device comprises an internal control unit comprising at least one of; a subcutaneously placed switch claim 86 , an electronic circuit claim 86 , a motor or a pump claim 86 , wherein said internal control unit is operable from the outside of the patient's body.88. An apparatus according to claim 86 , wherein the expandable member has a first mating part in its proximal part fitting with a second mating part of the control device in order to establish a detachable coupling between the expandable member and the control device through the wall of the urinary bladder.89. An apparatus according to claim 86 , wherein ...

SYSTEMS, DEVICES, AND METHODS FOR THE ACCURATE DEPLOYMENT OF AN IMPLANT IN THE PROSTATIC URETHRA

Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device. 1. A system for delivering an implantable device , the system comprising a delivery device comprising:an outer tubular member;an inner tubular member having a first inner lumen and a second inner lumen, the inner tubular member being slidable within the outer tubular member, wherein the first inner lumen is adapted to house an elongate grasper member configured to releasably couple with a proximal portion of an implant; anda distal control member slidable within the second inner lumen, wherein the distal control member comprises a retainer configured to releasably couple with a distal portion of the implant.2. The system of claim 1 , further comprising the implant.3. The system of claim 2 , wherein the implant is configured to maintain a prostatic urethra in an at least partially open state.4. The system of claim 3 , wherein the implant has a body comprising first and second ring-shaped structures and an interconnect that extends between the first and second ring-shaped structures.5. The system of claim 4 , wherein the body of the implant is only a single wire.6. The system of claim 2 , wherein the implant comprises a distal engagement member configured to releasably couple with the retainer.7. The system of claim 2 , wherein the implant comprises a proximal engagement member configured to releasably couple with the elongate grasper member.8. The system of claim 2 , wherein the implant comprises a wire-like distal engagement member that extends proximally away from a distal-most portion of the implant.9. The system of claim 2 , wherein the implant comprises a wire-like proximal engagement member.10. The system of claim 2 , wherein the first ring-shaped structure is the ...

ИСКУССТВЕННЫЙ ОРТОТОПИЧЕСКИЙ ЭНДОПРОТЕЗ МОЧЕВОГО ПУЗЫРЯ

Изобретение относится к области медицинской техники, и в частности, к искусственному ортотопическому эндопротезу мочевого пузыря и может быть использовано при замене мочевого пузыря пациента, когда последний страдает серьезными неизлечимыми болезнями такими, которые подвергают риску правильную его работу. Искусственный ортотопический эндопротез мочевого пузыря содержит первый участок, выполненный с возможностью соединения с уретрой пациента, и второй участок, выполненный с возможностью соединения с мочеточниками упомянутого пациента. Первый участок содержит сжимающийся кожух, изготовленный из многослойной силиконовой мембраны, имеющей внешнюю поверхность и внутреннюю поверхность, которые обе покрыты пиролитическим турбостратическим углеродом. Второй участок содержит рассасывающуюся крышку, содержащую полотно из волокон PGA, и раму, соединенную с упомянутой крышкой, изготовленную с использованием сополимера PGA/PLA. Кожух и крышка соединяются вместе вдоль их соответствующих границ, чтобы ...

АНТИРЕФЛЮКСНЫЙ КЛАПАН

Протез сфинктера мочевого пузыря

Изобретение относится к медицине, а именно к детской урологии, и может быть использовано для лечения недержания мочи у детей с пороками развития позвоночника и спинного мозга, пороками развития мочевого пузыря и уретры, стрессового недержания мочи. Искусственный имплантируемый сфинктер мочевого пузыря содержит манжетку 1, соединительную трубку 2, баллон-резервуар 3, в котором размещен механизм нагнетания и сбрасывания давления. 1 ил.

Протез мочеточника

ПРОТЕЗ МОЧЕТОЧНИКА, содержащий канал с фиксирующими манжетами, отличающийся тем, что, с целью обеспечения активного выведения мочи, канал выполнен в виде отдельных эластичных секций, каждая из -которых снабжена жестким корпусом и впускным и выпускным клапанами, при этом протез снабжен секционированным сильфоном с перегородкой, соединенной с приводным штоком, причем секции сильфона соединены трубками с полостями жестких корпусов. (О ...

Apparatus and methods for managing a shape of a junction between a bladder and urethra

The disclosure relates to devices and methods for managing a shape of a junction between a bladder and urethra, for example, to promote urinary continence after a prostatectomy. A device comprises an implant having a first portion and a second portion configured to form a hollow interior area within the implant extending along a longitudinal axis thereof. The first portion and the second portion are each configured to form a tubular shape centered about the longitudinal axis, the first portion is configured to receive a portion of a urethra therein and to be attached thereto, the second portion is configured to receive an extended portion of a bladder therein and to be attached thereto, and the implant is configured to encase a surgical connection of the urethra and the bladder in the hollow interior area of the implant and to support the operation of one or more sphincter muscles controlling the passage of liquid from the bladder to the urethra.

BLISTER RECONSTRUCTION

Orthotopic artificial bladder prosthesis

An orthotopic artificial bladder prosthesis is disclosed, comprising an enclosure or bag or balloon and hollow elements (200;300) for the forced connection of ureters and urethra to said bladder in the absence of sutures.

Minimally invasive implant and method

Apparatus and methods are provided for treating urinary incontinence, fecal incontinence, and other pelvic defects or dysfunctions, in both males and females, using one or more lateral implants to reinforce the supportive tissue of the urethra. The implants are configured to engage and pull (e.g., pull up) pelvic tissue to cause the lateral sub-urethral tissue, such as the endopelvic fascia, to tighten and provide slack reduction for improved support. As such, certain embodiments of the implants can be utilized to eliminate the need for mesh or other supportive structures under the urethra that is common with other incontinence slings.

Implantable device for internal urinary control

The present invention relates to an implantable apparatus for obtaining urinary control and emptying of the urinary bladder, thereby preventing from or treating involuntary urinary retention. In general terms, the apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient for discharging urine, and a control device for controlling the volume of the expandable member. The control device is adapted to be connected to the expandable member through the wall of the urinary bladder.

Orthotopic artificial bladder endoprosthesis

An orthotopic artificial bladder endoprosthesis comprises a casing (2) defining an enclosure for containing the urine of a patient; said casing (2) being made of a PGA fiber fabric; two first connectors (3) connected to the casing (2) and connectable to the ureters of the patient in order to allow the entrance of the urine into the enclosure; a second connector (4) connected to the casing (2) and connectable to the patient's urethra in order to allow the outflow of the urine from the enclosure; a catheter (7) inserted in the enclosure through said second connector (4) and comprising a duct (8) and an expandable element (9) in fluid communication with said duct (8).

Bistable spring construction for a stent and other medical apparatus

A dilating device for prostatic urethra

A dilating device for the prostatic urethra comprising: at least three, laterally connected ridges, wherein each ridge is configured to longitudinally engage with a different substantially longitudinal groove of the prostatic urethra of a patient,and wherein the at least three laterally connected ridges are configured to laterally compress to enable insertion into the prostatic urethra in a compressed configuration, and wherein the at least three laterally connected ridges are configured to laterally expand to a normally-open configuration upon deployment within the prostatic urethra, to exert a radially outwards force that dilates the prostatic urethra.

IMPROVED URETERAL STENT SYSTEM APPARATUS AND METHOD

A stent (30) having an elongate tubular configuration is formed of a plurality of elongate elements (84) interwoven or braided to form a tubular configuration. The elements (84) may be relatively strong, and rigid, but movable relative to each other within the weave or braid in order to provide the stent with generally soft characteristics. The elements may be formed of different materials, such as an absorbent material permitting the stent to be doped with materials, such as drugs, and chemicals. Even the absorbency can be controlled, and varied to provide a predetermined time-release of the absorbent.

SURGICAL SLINGS

The invention relates generally to surgical implants (100), and in various embodiments to surgical slings configured for promoting growth of well- organized collagenous tissue at an anatomical site. The slings comprise an agent including a pharmaceutical for promoting collageneous tissue growth.

URETHRAL DEVICE

The present disclosure relates to indwelling urethral device (1, 10) comprising an elongated tubular member (2, 20) extending along a longitudinal axis (L) from a distal inlet end portion (2a, 20a), via an intermediate portion (2b, 20b), to a proximal outlet end portion (2c, 20c), the tubular member defining a lumen (3, 30) extending along the longitudinal axis between the distal inlet end portion and the proximal outlet end portion, the distal end portion of the elongated tubular member comprising a plurality of urine inlet openings (4, 40), at least a part of the distal end portion being preconfigured to be reversibly transformable between a linear state for passage through the urethra when inserted there through and a preconfigured coiled state for anchored receipt within the bladder in the use position. The plurality of urine inlet openings is provided on the interior spiral section and urine inlet openings are absent on the exterior spiral section. The present disclosure furthermore ...

DEVICE, SYSTEMS AND METHODS FOR TREATMENT OF NEUROGENIC BLADDER

Embodiments of the invention provide apparatus, systems and methods for stimulating tissue in the urinary tract to initiate or facilitate urination. One embodiment provides an external urinary sphincter stimulation (EUSS) catheter for stimulating the external urinary sphincter (EUS), where the EUSS catheter includes nerve stimulation electrodes (NSES) for delivering current to nerves within or around the EUS in order to relax the EUS prior to urination. Other embodiments provide a system for stimulating the EUS including the EUSS catheter and a controller operatively coupled to the EUSS catheter, where the controller includes a pulse generator for delivering current to the NSES. Other embodiments provide methods for positioning the EUSS catheter in the patient's body including in the EUS using a urethral approach. Embodiments of the invention are particularly useful for initiating and/or controlling urination for patients who have lost the ability to voluntarily urinate due to neurogenic ...

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis comprises a casing (2) made of a PGA fiber fabric; said casing (2) having two first connectors (3) for the connection with the ureters of a patient and a second connector (4) for the connection with the urethra of a patient; a support element (5) being inserted in said casing (2); said support element (5) being switchable between an extended configuration, in which it supports and maintains in position the casing (2), and a retracted configuration.

SMOOTH MUSCLE CELL CONSTRUCTS

The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.

DEVICE FOR PROTECTING AND CLEANING THE BLADDER LUMEN

The invention relates to a device (1), in particular for protecting and for cleaning the bladder lumen, consisting of at least one functional body (2) which can be spatially expanded in a variable manner and can be modified at least partially from a small state into a larger state. Said device (1) protects the bladder lumen from bacterial invasion when the functional body (2) is inserted into the bladder and helps an infected bladder during mechanical cleaning and subsequent healing. The invention also relates to the use of the device (1) for medical, in particular prophylactic and therapeutic purposes.

IMPROVEMENTS RELATING TO DECELLULARISATION OF TISSUE MATRICES FOR BLADDER IMPLANTATION

The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.

TISSUE INJECTABLE COMPOSITION AND METHOD OF USE

SURGICAL SLINGS

The invention relates generally to surgical implants, and in various embodiments to surgical implants configured for promoting growth of well-organized collagenous tissue at an anatomical site. 1. A surgical implant comprising a surgical sling for implantation at an anatomical site in a body of a patient , and an agent , associated with the surgical sling , and including a pharmaceutical for promoting collagenous tissue growth near the anatomical site.2. The surgical implant of claim 1 , wherein the agent includes a therapeutic agent.3. The surgical implant of claim 1 , wherein the agent includes a growth factor.4. The surgical implant of claim 1 , wherein the agent includes a stem cell.5. The surgical implant of claim 1 , wherein the agent includes a fibroblast.6. The surgical implant of claim 1 , wherein the agent includes a myoblast.7. The surgical implant of claim 1 , wherein the agent includes at least one of an analgesic agent claim 1 , anesthetic agent and an antispasmodic agent.8. The surgical implant of claim 1 , wherein the surgical sling includes surface features for promoting organized collagenous tissue growth.9. The surgical implant of claim 8 , wherein the surgical sling has first and second sides and the surface features are located on at least one of the first and second sides.10. The surgical implant of claim 8 , wherein the surgical sling has first and second sides and the surface features include through apertures extending between the first and second sides.11. The surgical implant of claim 8 , wherein the surgical sling has first and second sides claim 8 , both including the surface features.12. The surgical implant of claim 8 , wherein the surface features include channels extending axially along at least a portion of a side of the surgical sling.13. The surgical implant of claim 12 , wherein the channels extend along substantially an entire length of the surgical sling.14. The surgical implant of claim 12 , wherein the channels are formed ...

CELL SCAFFOLD CONSTRUCTS

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues. 1. A urinary diversion for a defective bladder in a subject comprisinga) a first implantable, biocompatible construct comprising a tubular scaffold having a first end configured to connect to an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter; andb) an autologous cell population that is not derived from the defective bladder, deposited on or in a surface of the scaffold.2. The urinary diversion of wherein the scaffold further comprises a second side opening configured to connect to a second ureter.3. The urinary diversion of wherein the first end is configured to be positioned flush with the abdominal wall.4. The urinary diversion of wherein the first end is configured to be sutured to the skin of the subject.5. The urinary diversion of wherein the first end is configured to form a stoma.6. The urinary diversion of wherein the stoma further comprises a stoma button.7. The urinary diversion of or wherein the scaffold further comprises a washer ring configured to form a stoma.8. The urinary diversion of claim 1 , wherein the biocompatible scaffold is biodegradable.9. The urinary diversion of claim 1 , wherein the scaffold comprises a material selected from the group consisting of polyglycolic acid claim 1 , polylactic acid claim 1 , and a copolymer of polyglycolic acid and polylactic acid.10. The urinary diversion of claim 1 , wherein the cell population is a smooth muscle cell population.11. The urinary diversion of wherein the diversion is a replacement for the defective bladder.12. The urinary diversion of claim 1 , wherein the diversion is temporary.13. The urinary diversion of claim 1 , wherein the diversion is permanent.14. The urinary diversion of claim 1 , wherein the ...

Method of treating incontinence and treatment device including non-porous cuff and extending members

A method of treating urinary incontinence includes making an incision and exposing tissue of a urethra. The method additionally includes inserting a non-porous sheet into the incision and forming a cuff around the urethra with the non-porous sheet by directing a first end of the non-porous sheet through a slot formed in a second end of the non-porous sheet. The method additionally includes directing an extending member that is attached to the non-porous sheet to a location exterior of a pelvis. The method further includes configuring the cuff to tighten around the urethra when pulling on the first end of the non-porous sheet, and configuring the cuff to be loosely positioned around the urethra when pulling on the extending member.

INCONTINENCE TREATMENT DEVICE INCLUDING NON-POROUS CUFF AND EXTENDING MEMBERS

An incontinence treatment device includes a non-porous support and an extending member. The non-porous support has a first end portion provided with a slot and a second end portion. The second end portion is insertable through the slot to form a cuff that is configured for placement around a urethra of a user. The extending member is attached to the support at a junction located between the first end portion and the second end portion. Tension applied to the second end portion is adapted to draw the junction toward the slot to tighten the cuff and thus provide the user with a continent state. Tension applied to the extending member is adapted to draw the juncture away from the slot and expand the cuff and thus allow the user to urinate. 1. An incontinence treatment device configured to be implanted in a body of a user , the incontinence treatment device comprising:a biocompatible non-porous support configured for implantation in the body of the user and having a first end portion provided with a slot and a second end portion, the second end portion is insertable through the slot to form a cuff that is configured for placement around a urethra of the user; anda biocompatible extending member configured for implantation in the body of the user and attached to the support at a junction located between the first end portion and the second end portion;wherein tension applied to the second end portion is adapted to draw the junction toward the slot to tighten the cuff and thus provide the user with a continent state;wherein tension applied to the extending member is adapted to draw the junction away from the slot and expand the cuff and thus allow the user to urinate.2. The incontinence treatment device of claim 1 , wherein the support has a height extending between a first side and a second side of the support claim 1 , and the second end portion and the extending member both taper from a first width that is substantially equal to the height of the support to a second ...

INCONTINENCE TREATMENT DEVICE INCLUDING NON-POROUS SUB-URETHRAL SLING

An incontinence treatment device includes a non-porous sub-urethral sling provided with an adjustment device. The device includes first and second anchors coupled to the sling. The second anchor includes a channel formed through the second anchor and a restrictor segment provided in the channel. The adjustment device is movable through the channel formed through the second anchor. The resistor segment is configured to resist movement of the adjustment device through the channel. 1. An incontinence treatment device comprising:a non-porous sub-urethral sling;a first extension member attached to a first end of the sling;a first anchor attached to the first extension member;a first line attached to the first end of the sling and inserted through a bore formed through the first anchor, the first line including a stop device fixed to the first line with the first anchor positioned between the stop device and the sling;a second extension member attached to a second end of the sling;a second anchor attached to the second extension member, the second anchor including a channel formed through the second anchor and a restrictor segment provided in the channel; anda second line attached to the second end of the sling and inserted through the channel, the second line including an adjustment device attached to the second line that is movable through the channel formed through the second anchor;wherein the restrictor segment is configured to resist movement of the adjustment device through the channel.2. The incontinence treatment device of claim 1 , wherein the non-porous sub-urethral sling is a substantially solid film that is adapted to reduce tissue growth onto a surface of the non-porous sub-urethral sling.3. The incontinence treatment device of claim 1 , wherein each of the first and second anchors includes at least one protrusion projecting outward relative to a central axis of the anchor that is configured to engage with tissue.4. The incontinence treatment device of claim ...

Safety stent

A stent can comprise a first elongate member and a second elongate member. The first elongate member can be configured to extend within a body lumen of a subject. The second elongate member can have (i) a first end portion connected to the first elongate member and (ii) a second end portion. An injection lumen can extend within the second elongate member for injecting a substance into at least a part of the body lumen.

BLADDER RECONSTRUCTION

The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material. 1a. providing a biocompatible synthetic, or natural, polymeric matrix structure in the shape of a bladder, or portion of a bladder, wherein said polymeric matrix is coated with a biocompatible and biodegradable shape-setting material comprising a liquefied poly-lactide-co-glycolide copolymer;b. depositing at least one first cell population on or in said polymeric matrix; andc. implanting the shaped polymeric matrix of step (b) into the human patient at a site of a bladder for the formation of a laminarily organized functional bladder structure.. A method for the replacement or repair of a bladder, or portion of a bladder, in a human patient in need of such treatment comprising the steps of: This application is a continuation of U.S. application Ser. No. 13/344,644 filed on Jan. 6, 2012, which is a continuation of U.S. application Ser. No. 12/468,983 filed on May 20, 2009, now U.S. Pat. No. 8,128,707, issued on Mar. 6, 2012, which is continuation of U.S. application Ser. No. 10/394,640 filed on Mar. 21, 2003, now U.S. Pat. No. 7,569,076, issued on Aug. 4, 2009, which is a continuation of U.S. application Ser. No. 09/600,455 filed on Jul. 17, 2000, now U.S. Pat. No. 6,576,019, issued on Jun. 10, 2003, which is a 35 U.S.C. §371 National Stage of International Application No. PCT/US98/22962 filed ...

HEMISPHERE FOR BLADDER EXPANSION IN PATIENTS WITH LOW COMPLIANCE

A device for the expansion of an atrophied bladder formed by a hemisphere (), as a single piece, in biocompatible material, characterized in that the material is selected from polylactic acid (PLA) and silicone coated with pyrolytic turbostratic carbon or with amorphous diamond-like carbon. 18-. (canceled)9. An implant for increasing the volume of an atrophied bladder , said implant being constituted by a domed hemisphere device , internally hollow with a predetermined volume , made in a single piece in biocompatible material , the internal and external surfaces of said hemisphere are without covering from semination of cultured cells , characterised in that said material is silicone coated with pyrolytic turbostratic carbon or with amorphous diamond-like carbon , and in that said hemisphere is suitable for acting as a scaffold and for growing thereon autologous cells from fibrous capsule , generated by the process of tissue reconstruction of the patient , after its insertion inside the patient.10. The implant according to wherein the diameter of the hemisphere is about 80 mm.11. The implant according to wherein the hemisphere has a rim turned upwards.12. The implant according to wherein the hemisphere has a thickness ranging from 0.1 mm to 2 cm.13. The implant according to wherein the hemisphere has on the rim a plurality of holes claim 12 , with a diameter of the holes comprised between 0.1 and 3.0 mm.14. The implant according to wherein the coating of pyrolytic turbostratic carbon or amorphous diamond-like carbon is a microfilm of about 0.2-0.3 micron.15. The implant according to wherein the suture thereof to the bladder is performed by using suture threads made of absorbable or non-absorbable material.16. The implant according to wherein the hemisphere has a rim turned upwards.17. The implant according to wherein the hemisphere has a thickness ranging from about 0.5-0.6 mm. The present invention relates to a hemisphere for bladder expansion in patients with low ...

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis includes a first portion connectable to a urethra of a patient and a second portion connected to the ureters of the patient; the first portion including a collapsible cover made of a multi-layered silicone membrane having an external surface and an internal surface both coated with pyrolytic turbostratic carbon; the second portion including a resorbable cap including a fabric of PGA fibres and a frame, coupled with the cap, made using PGA/PLA copolymer; the cover and the cap being connected together along their respective edges, to define an enclosure. 1. An orthotopic artificial bladder endoprosthesis comprising a first portion connectable to a urethra of a patient and a second portion connectable to the ureters of said patient;said first portion comprising a collapsible cover made of a multi-layered silicone membrane having an external surface and an internal surface both coated with pyrolytic turbostratic carbon;said second portion comprising a resorbable cap comprising a fabric of PGA fibres and a frame, coupled with said cap, made using PGA/PLA copolymer; said cover and said cap being connected together along their respective edges, to define an enclosure.2. The endoprosthesis according to claim 1 , wherein the cover comprises a strip protruding from said edge of the cover and made of a biocompatible and non-resorbable material; said strip being fixed to said edge of said cap.3. The endoprosthesis according to claim 2 , wherein said strip is made of Dacron® and/or Goretex®.4. The endoprosthesis according to claim 2 , wherein said strip is firmly comprised between two adjacent layers of the membrane at the external surface of the cover.5. The endoprosthesis according to claim 1 , wherein said strip extends along the entire edge of the cover.6. The endoprosthesis according to claim 1 , wherein said frame comprises a plurality of arms arranged in a star and defining a dome profile.7. The endoprosthesis according to ...

STENT PUSHER ASSEMBLY

Provided is a stent pusher assembly for positioning a ureteral stent, the stent pusher assembly having an inner and outer stent pusher. The stent pusher assembly positions the ureteral stent in a patient's kidney and bladder without a bladder fixing portion of the stent entering a ureteral passage-way, thereby minimizing irritation to the patient. 1. A method for positioning a ureteral stent in a kidney , ureteral passageway and bladder of a patient using a stent pusher assembly having an inner and outer pusher , the ureteral stent including a bladder portion configured to be positioned in the bladder , a kidney portion configured to be positioned in the kidney and the ureteral passageway , and at least one tether coupled to the bladder portion and the kidney portion , the method including:advancing a guidewire into the bladder, the ureteral passageway and the kidney;advancing the kidney portion and bladder portion over the guidewire;advancing the outer pusher over the guidewire;advancing the outer pusher along the guidewire until a second end of the outer pusher abuts a first end of the bladder portion;advancing the outer pusher towards the kidney to advance the bladder portion and kidney portion until the kidney portion is substantially positioned in the ureteral passageway;advancing the inner pusher over the guidewire, through a lumen of the outer pusher and through a lumen of the bladder portion until a second end of the inner pusher abuts a second end of the kidney portion; andadvancing the inner pusher towards the kidney to advance the kidney portion such that the second end of the kidney portion is disposed in the ureteral passageway and a first end of the kidney portion is disposed in the kidney.2. The method according to claim 1 , wherein the kidney portion and bladder portion are in respective restrained shapes when the guidewire extends through the kidney portion and bladder portion.3. The method according to claim 1 , further including: withdrawing the ...

DECELLULARISATION OF TISSUE MATRICES FOR BLADDER IMPLANTATION

The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro. 135-. (canceled)36. A biocompatible implant material produced by a method comprising:(i) immersing a bladder material in a buffer solution at a mild alkaline pH which includes a proteolytic inhibitor;(ii) expanding the bladder by introducing a sufficient volume of the same buffer solution into an interior cavity of the bladder so as to stretch and thin the bladder wall; and(iii) continuing decellularisation of the bladder by replacing and introducing fresh solutions both around the exterior surface of the bladder and into the bladder interior itself so as to maintain expansion of the bladder during decellularisation and to maintain the histoarchitecture of the bladder material.37. The biocompatible implant material of claim 36 , wherein the biocompatible implant material is characterised by a DNA content of less than 0.2 μg/mg dry weight claim 36 , a suture retention strength (Fmax) of between 3-6 N claim 36 , ultimate tensile strength (apex to base) of between 1-4 MPa claim 36 , and failure strength (apex to base) of between 70-150%.38. A product comprising decellularised whole bladder claim 36 , sheet or patch thereof claim 36 , the product being characterised by a DNA content of less than 0.2 μg/mg dry weight claim 36 , a suture retention strength (Fmax) of between 3-6 N claim 36 , ultimate tensile strength (apex to base) of between 1-4 MPa claim 36 , and failure strength (apex to base) of between 70-150%.39. A tissue matrix obtainable by a method comprising:immersing a bladder material in a buffer solution at a ...

MULTI-LUMEN DRUG DELIVERY DEVICES AND METHODS

Drug delivery devices are provided herein and include an elongated, elastic body extending between a first end and a second end, wherein the elastic body comprises a water permeable wall structure having defining an elongated drug reservoir lumen extending between the first and second ends. One or more secondary lumens are structured (e.g., positioned, sized, shaped, and optionally filled) to be effective to retard or prevent in vivo diffusion of (i) water into the drug reservoir lumen and/or (ii) solubilized drug out of the drug reservoir lumen. 1. A drug delivery device for controlled release of drug into the urinary bladder of a patient comprising:an elongated, elastic body extending between a first end and a second end, wherein the elastic body comprises a water permeable outer wall structure having a cylindrical shaped external surface extending between the first and second ends;an elongated hub structure located within, and coaxial with, the outer wall structure and extending between the first and second ends;two or more spoke structures extending between and connecting the outer wall structure and the hub structure, the spoke, outer wall, and hub structures defining at least one elongate drug reservoir lumen and at least one air lumen;a drug payload disposed in the at least one drug reservoir lumen,wherein the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of the patient and a coiled retention shape which is suited to retain the device within the urinary bladder.2. The device of claim 1 , wherein the hub structure comprises an annulus in which the lumen of the annulus includes an elastic retention frame disposed therein claim 1 , the elastic retention frame imparting the coiled retention shape to the device.3. The device of claim 1 , wherein the hub structure is shape set to impart the coiled retention shape to the device.4. The device of claim 1 , ...

PIXEL ARRAY MEDICAL SYSTEMS, DEVICES AND METHODS

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject. 198-. (canceled)99. A device comprising:a carrier configured to removeably couple to a chamber, wherein the carrier includes a drive shaft configured to rotate; anda cannula assembly configured to removeably couple to the chamber and to the drive shaft, wherein the cannula assembly includes at least one cannula configured to be rotated by the drive shaft and including a sharpened distal end forming a cylindrical scalpel configured to incise skin pixels, wherein the cannula is coupled to the chamber and configured to pass the skin pixels.100. The device of claim 99 , wherein the chamber comprises a first end and a second end claim 99 , wherein the carrier is configured to removeably couple to the first end.101. The device of claim 100 , wherein the cannula assembly is configured to removeably couple to the second end.102. The device of claim 101 , wherein the chamber is configured as a collection chamber to collect the skin pixels.103. The device of claim 102 , wherein the cannula assembly includes a vacuum port configured to couple the at least one cannula to a vacuum source.104. The device of claim 103 , wherein the chamber is configured to include a vacuum fitting claim 103 , wherein the vacuum fitting is removeable and configured to couple the vacuum port to the vacuum source.105. The device of claim 104 , wherein the vacuum is configured to pull the skin pixels into the chamber via the shaft of the at least one cannula.106. The device of claim 102 , comprising a first end cap configured to removeably couple to the second end of the chamber.107. The device of claim 106 , wherein the first end cap includes a depth guide ...

SYSTEM AND METHOD FOR USE OF FLEXIBLE ANTI-REFLUX URETERAL STENT

The multi-material stent includes a renal portion and a bladder portion with respective, different hardness. A valve is disposed within the stent to guide liquid from the renal portion of the stent to the bladder portion of the stent. The present invention relates towards systems and method for stents. More particularly, the invention relates to a stent designed to increase patient comfort by minimizing irritation and reflux through the use of a stent that incorporates one or more flexible elements, which may involve materials with varying degrees of hardness, and a valve disposed therein. 1. A stent , comprising:a renal portion sized to be disposed proximate a patient's kidney and having a hardness characterized between about 20 Shore A to about 90 Shore A;a bladder portion sized to be disposed proximate a patient's bladder and having a hardness characterized between about 5 Shore A to about 60 Shore A; anda valve disposed within the stent to guide liquid from the renal portion toward the bladder portion of the stent.2. The stent of claim 1 , wherein the renal portion includes a self-retaining securement mechanism.3. The stent of claim 1 , wherein the valve inhibits fluid flow toward the renal portion of the stent.4. The stent of claim 1 , wherein a flexible connector conduit joins the renal portion of the stent to the bladder portion of the stent.5. The stent of claim 1 , wherein the renal portion comprises a first material and the bladder portion comprises a second material different from the first material.6. The stent of claim 5 , wherein the first material is polyurethane.7. The stent of claim 6 , wherein the second material is silicone.8. The stent of claim 1 , wherein the bladder portion further includes a tip disposed at an end thereof.9. The stent of claim 8 , wherein the tip includes sloped walls and an opening therein.10. The stent of claim 1 , wherein the valve is disposed in the renal portion.11. A stent claim 1 , comprising:a renal portion sized to be ...

Implantable device for internal urinary control

The present invention relates to a method for implanting an implantable apparatus for obtaining urinary control and emptying of the urinary bladder, thereby preventing from or treating involuntary urinary retention. In general terms, the apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient for discharging urine, and a control device for controlling the volume of the expandable member. The control device is adapted to be connected to the expandable member through the wall of the urinary bladder. 185.-. (canceled)86. A method implanting an apparatus for treating a urinary retention of a patient by discharging urine from a mammal urinary bladder through a mammal urethra , comprising the steps of:cutting the skin of the patient;dissecting an area of at least one portion of a urinary bladder of a patient;incising an opening in a wall of the urinary bladder;placing an expandable member inside the urinary bladder;placing a control device outside the urinary bladder, wherein the control device is adapted to control the volume of the expandable member for emptying the urinary bladder; andreleasably interconnecting the expandable member and the control device with an interconnection device comprising a detachable coupling, to form a detachable interconnection between the expandable member and the control device through wall of the urinary bladder.87. The method according to claim 86 , wherein the detachable coupling comprises a first mating part and a second mating part claim 86 , the first mating part being arranged in a proximal part of the expandable member and to fit with the second mating part arranged attached to the control device.88. The method according to claim 86 , wherein said detachable coupling is detachable in situ in the patient.89. The method according to claim 86 , wherein the step of placing a control device outside of the urinary bladder comprises subcutaneously placing a switch in the patient.90. ( ...

SYSTEMS AND METHODS FOR ASSISTING PATIENTS IN EMPTYING THEIR BLADDER EFFICIENTLY

The present disclosure relates generally to systems, components, devices and methods for assisting a patient to empty his or her weakened or paralyzed bladder or a neobladder efficiently. The system and method includes a pressure sensor for sensing the pressure in the urinary bladder of a patient and an alert mechanism which alerts the patient of the bladder fullness and the need to void. An actuating device is operably coupled to the system to selectively activate a compression assembly. When activated, the compression assembly compresses the bladder to permit emptying of the bladder. 1. A method for assisting a patient to empty his or her bladder , comprising:a. implanting a bladder pressure sensor to sense the pressure in a patient's bladder;b. implanting a compression assembly, wherein the compression assembly includes a pair of plates arranged adjacent opposing walls of the patient's bladder wherein the plates are biased apart and are selectively movable toward each other to compress the bladder;c. providing an alert mechanism;d. comparing the pressure reading with a predetermined threshold and activating the alert mechanism to alert the patient when the bladder pressure reading exceeds the predetermined threshold; and,e. actuating the compression assembly to compress the bladder when the patient triggers an actuator.2. The method of claim 1 , comprising implanting a controller in the patient claim 1 , the controller having a processor and a memory unit with data indicating the predetermined bladder pressure threshold stored in the memory unit.3. The method of claim 2 , wherein the predetermined threshold at which the alert is activated is communicated to the memory unit using a programmer device external to the patient's body.4. The method of claim 1 , wherein the alert mechanism provides a plurality of alert levels to the patient correlating to the bladder pressure reading successively exceeding a corresponding plurality of predetermined thresholds.5. The ...

METHOD AND APPARATUS FOR TREATING URETHRAL STRICTURE

A treatment device for treating a treatment area of a body lumen includes an elongated member insertable into the body lumen, a delivery member guidable along a longitudinal axis of the elongated member, and a treatment part for contacting the treatment area, wherein the delivery member is configured to deliver the treatment part to the treatment area. 1. A treatment device for treating a treatment area of a body lumen , comprising:an elongated member insertable into the body lumen;a delivery member guidable along a longitudinal axis of the elongated member; anda treatment part for contacting the treatment area;wherein the delivery member is configured to deliver the treatment part to the treatment area.2. The treatment device of claim 1 , wherein the delivery member possesses a fixing member which fixes the delivery member to the elongated member.3. The treatment device of claim 2 , wherein the fixing member comprises an expandable member.4. The treatment device of claim 3 , wherein the expandable member has an annular configuration with an expandable outer surface and a fixable inner surface with respect to the elongated member.5. The treatment device of claim 3 , wherein the expandable member has an annular configuration with an expandable outer surface and an expandable inner surface.6. The treatment device of claim 3 , wherein the expandable member comprises an inflatable balloon.7. The treatment device of claim 6 , wherein the inflatable balloon possesses an inner portion and an outer portion claim 6 , the delivery member is fixed to the elongated body by inflating the inner portion claim 6 , and the treatment part is contacted with the treatment area by inflating the outer portion.8. The treatment device of claim 1 , wherein the delivery member comprises an expandable member claim 1 , and contact with the treatment area is maintained by inflating the expandable member.9. The treatment device of claim 8 , wherein the expandable member has an annular ...

ABSORBABLE CAP FOR BLADDER ENLARGEMENT IN PATIENTS WITH LOW COMPLIANCE OR FOR THE REPLACEMENT OF A VAST PORTION OF BLADDER FOLLOWING BILHARZIA

A description is given of a domed cap () for the enlargement of an atrophied bladder (), in biocompatible and absorbable material including a textile () made with yarns or with monofilaments deriving from PGA fibres, characterised in that the textile () is supported by a star-shaped frame with domed profile, formed by a plurality of radial strips () manufactured by injection of a PGA/PLA copolymer, the cap () being suitable for growing thereon autologous fibrous capsule cells, generated by the process of tissue reconstruction, after its insertion inside the patient. 111-. (canceled)121002001001001001. Self-supporting domed cap () , ready for use without previous cell covering , for the enlargement of an atrophied bladder () or replacement of a vast portion of bladder following a coverage of said cap () by growing autologous fibrous capsule cells generated by the process of tissue reconstruction after the insertion of said patch () inside the patient , said cap () comprising an absorbable textile () , preferably texturized , made with multifilament or monofilament yarns deriving from PGA fibres ,{'b': 1', '3, 'said cap being characterized in that said absorbable textile () is supported by a non porous heat-formed self-supporting frame with domed profile, flexible and harmonic, formed by a plurality of curved and heat-formed reinforcement strips () made with an absorbable copolymer in PGA/PLA, each of said strips forming a portion of arc which departs from the top of the frame downwards and being substantially rigid but elastic and with a slight curvature which allows the frame to take on a domed configuration.'}131001. Cap () according to wherein said frame is attached to the textile () by means of absorbable sutures claim 12 , preferably a monofilament in polydioxanone (PDO) with slow absorption such as for example absorbable MONOTIME®.141. Cap according to wherein the thickness of the textile () ranges from 0.1 mm to 2 cm claim 12 , preferably 0.3-0.6 mm claim 12 , ...

SYSTEMS, DEVICES, AND METHODS FOR THE ACCURATE DEPLOYMENT OF AN IMPLANT IN THE PROSTATIC URETHRA

Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device. 1. A system for delivering an implantable device , comprising:a delivery device comprising a first elongate member having an inner lumen, an elongate grasper member slidable within the inner lumen and configured to hold a proximal portion of an implant, and a distal control member configured to hold a distal portion of the implant; anda proximal control device coupled with a proximal end region of the delivery device, the proximal control device comprising a user actuator and a housing.2. The system of claim 1 , wherein the proximal control device comprises a first gear assembly within the housing claim 1 , the proximal control device being configured to translate movement of the user actuator into movement in the first gear assembly.3. The system of claim 1 , wherein the proximal control device comprises a switch that selects between movement of the first gear assembly in a first direction and movement of the first gear assembly in a second direction.4. The system of claim 3 , wherein the user actuator is coupled with a yoke that is coupled with a first pawl and a second pawl.5. The system of claim 4 , wherein the switch selectively engages either the first pawl or the second pawl with a pinion gear.6. The system of claim 5 , wherein the proximal control device is configured such that rotation of the pinion gear causes rotation of a face gear.7. The system of claim 6 , wherein the proximal control device is configured such that rotation of the face gear causes rotation of a reel coupled with the elongate grasper member.8. The system of claim 7 , further comprising:an input gear engaged with the face gear; anda reel gear engaged with the input gear, the reel gear coupled ...

CONTROLLED EXTENSION STENT

The present disclosure relates generally to controlled extension medical stents, and more particularly to controlled extension devices positioned in the body to stent the ureter and facilitate drainage from the kidney to the bladder. 1. A flexible controlled extension stent configured to allow controlled extension in response to bodily movement when implanted in a body lumen , the stent comprising:a filament wound into a plurality of coils defining a lumen about a longitudinal axis of the stent along the length of the stent;wherein:one or more adjacent coils are attached together into separable contact;the stent is expandable along the length thereof, in response to bodily movement, from a longitudinally non-extended state in which adjacent coils are in substantial contact with one another and two or more adjacent coils are attached together, and a longitudinally extended state in which adjacent coils are separated from one another and coils which were attached together in the non-extended state are no longer attached together to accommodate movement of the body lumen in which the flexible controlled extension stent is implanted.2. The stent of claim 1 , wherein the adjacent coils are tacked together on at least one substantially helical contact line running between the coils along at least portions of the stent length.3. The stent of claim 2 , further comprising a reflowed substantially smooth outer surface along the at least one substantially helical contact line.4. The stent of claim 1 , wherein the two or more adjacent coils of the filament which are attached together are tacked together.5. The stent of claim 1 , wherein a proximal and a distal end of the stent each have an annular tail.6. The stent of claim 1 , wherein coils at a distal end of the stent form a spiraled cone-shape claim 1 , the cone-shape widening in diameter toward the distal end of the stent.7. The stent of claim 1 , wherein certain of the adjacent coils in the non-extended state are tacked ...

METHOD OF REMOVING AN INFLATED IMPLANT FROM A BLADDER

An inflated implant, such as an attenuation device, previously implanted in a urinary bladder can later be removed according to a number of different methods. Preferably, removal is accomplished transurethrally. In one embodiment, removal is accomplished by reducing the inflated implant from an enlarged profile to a reduced profile so that it may be withdrawn transurethrally by a removal system. The removal system can be configured differently depending upon whether reduction from the enlarged profile to the reduced profile is accomplished by deflation, compression, and/or other ways. 1. A device for treating symptoms of a urinary tract dysfunction, comprising a compressible attenuation device having an expanded volume within the range of from about 1 cc to about 400 cc, and a valve for permitting filling of the attenuation device through a filling device; wherein the valve has a first pair of complementary surfaces for resisting deflation of the attenuation device, and a second pair of complementary surfaces for resisting additional filling of the attenuation device when the attenuation device is exposed to an external pressure which is greater than an internal pressure within the attenuation device. This application is a continuation of U.S. patent application Ser. No. 14/512,228, filed Oct. 10, 2014, which is a continuation of U.S. patent application Ser. No. 13/660,814, filed Oct. 25, 2012, now U.S. Pat. No. 8,858,460, which is a continuation of U.S. patent application Ser. No. 12/343,120, filed Dec. 23, 2008, now U.S. Pat. No. 8,298,132, which is a divisional of U.S. patent application Ser. No. 10/391,448 filed Mar. 17, 2003, now U.S. Pat. No. 7,470,228, which is a continuation of U.S. patent application Ser. No. 10/391,446, filed Mar. 17, 2003, now U.S. Pat. No. 6,976,950, which claims priority to U.S. Provisional Patent Appl. No. 60/415,949, filed Oct. 3, 2002, U.S. patent application Ser. No. 10/391,446 is also a continuation-in-part of U.S. patent ...

COUPLING A BODY CONDUIT TO TISSUE

A method for coupling a body conduit to tissue is provided. The method includes engaging an implant about an outer surface of a catheter. The implant receives a bioactive agent having tissue growth properties. The method involves inserting the catheter through the body conduit and into a tissue opening across a resected area, positioning the implant in the resected area, inflating a balloon to anchor the catheter within the tissue opening such that the implant bridges the body conduit and the tissue opening across the resected area, and maintaining the catheter and the implant in vivo to enable the bioactive agent to secure the implant in the resected area to permanently bridge the body conduit and the tissue opening. 1. A method for coupling a body conduit to tissue , the method comprising:engaging an implant about an outer surface of a catheter, the implant configured to receive a bioactive agent having tissue growth properties;inserting the catheter through the body conduit and into a tissue opening across a resected area;positioning the implant in the resected area;inflating a balloon to anchor the catheter within the tissue opening such that the implant bridges the body conduit and the tissue opening across the resected area; andmaintaining the catheter and the implant in vivo to enable the bioactive agent to secure the implant in the resected area to permanently bridge the body conduit and the tissue opening.2. The method of claim 1 , further including deflating the balloon to remove the catheter after the implant is permanently secured in vivo.3. The method of claim 1 , wherein the bioactive agent includes at least one of epithelial cells claim 1 , stem cells claim 1 , epidermal growth factors claim 1 , fibroblast growth factors claim 1 , or chitosan.4. The method of claim 1 , further including sliding the implant over the outer surface of the catheter to position the implant on the outer surface of the catheter claim 1 , wherein the catheter includes a Foley ...

COUPLING A BODY CONDUIT TO TISSUE

A catheter assembly for coupling a body conduit to tissue is provided. The catheter assembly includes a catheter and an implant selectively positionable about an outer surface of the catheter. The implant is configured to receive a bioactive agent having tissue growth properties. The implant is configured to act as a bridge between the body conduit and the tissue and is separable from the catheter assembly. 1. A catheter assembly for coupling a body conduit to tissue , the catheter assembly comprising:an elongated member having an outer surface and an inner surface, the outer surface defining a distal opening;a balloon supported on the outer surface of the elongated member adjacent to the distal opening;a first port defined in a proximal end of the elongated member and in fluid communication with the distal opening;a second port defined in the proximal end of the elongated member and in fluid communication with the balloon; andan implant selectively positionable about the outer surface of the elongated member and configured to receive a bioactive agent having tissue growth properties, the implant separable from the catheter assembly and configured to act as a bridge between the body conduit and the tissue.2. The catheter assembly of claim 1 , wherein the implant is at least partially formed from a collagen or a collagen copolymer.3. The catheter assembly of claim 1 , wherein the bioactive agent includes at least one of epithelial cells claim 1 , stem cells claim 1 , epidermal growth factors claim 1 , and fibroblast growth factors.4. The catheter assembly of claim 3 , wherein the bioactive agent is impregnated within the implant.5. The catheter assembly of claim 1 , wherein the implant has a tubular configuration that engages the outer surface of the elongated member.6. The catheter assembly of claim 1 , wherein the implant has a planar configuration that engages the outer surface of the elongated member.7. The catheter assembly of claim 1 , wherein the outer surface ...

CELL SCAFFOLD CONSTRUCTS

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues. 1. A urinary diversion for a defective bladder in a subject comprisinga) a first implantable, biocompatible construct comprising a tubular scaffold having a first end configured to connect to an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter; andb) an autologous cell population that is not derived from the defective bladder, deposited on or in a surface of the scaffold.2. The urinary diversion of wherein the scaffold further comprises a second side opening configured to connect to a second ureter.3. The urinary diversion of wherein the first end is configured to be positioned flush with the abdominal wall.4. The urinary diversion of wherein the first end is configured to be sutured to the skin of the subject.5. The urinary diversion of wherein the first end is configured to form a stoma.6. The urinary diversion of wherein the stoma further comprises a stoma button.7. The urinary diversion of claim 5 , wherein the scaffold further comprises a washer ring configured to form a stoma.8. The urinary diversion of claim 1 , wherein the biocompatible scaffold is biodegradable.9. The urinary diversion of claim 1 , wherein the scaffold comprises a material selected from the group consisting of polyglycolic acid claim 1 , polylactic acid claim 1 , and a copolymer of polyglycolic acid and polylactic acid.10. The urinary diversion of claim 1 , wherein the cell population is a smooth muscle cell population.11. The urinary diversion of wherein the diversion is a replacement for the defective bladder.12. The urinary diversion of claim 1 , wherein the diversion is temporary.13. The urinary diversion of claim 1 , wherein the diversion is permanent.14. The urinary diversion of claim 1 , wherein ...

UROLOGICAL DEVICE INCLUDING A VALVE RETAINED IN A URINARY CATHETER

A urological device includes a valve retained in a urinary catheter. The urinary catheter has a first portion that is insertable into a urethra and a second portion adapted to remain outside of the urethra when the first portion is inserted into the urethra. The valve has a closed configuration adapted to prevent urine from exiting the urinary catheter and an open configuration adapted to allow urine to flow through and exit the urinary catheter. The valve is adapted to move from the closed configuration to the open configuration in response to a hydrodynamic pressure of at least 750 mm H2O applied to the valve for at least 5 seconds. 1. A urological device adapted to treat urinary incontinence , the urological device comprising:a urinary catheter comprising a first portion that is insertable into a urethra and a second portion adapted to remain outside of the urethra when the first portion is inserted into the urethra; anda valve retained in the urinary catheter;wherein the valve has a closed configuration adapted to prevent urine from exiting the urinary catheter and an open configuration adapted to allow urine to flow through and exit the urinary catheter;wherein the valve is adapted to move from the closed configuration to the open configuration in response to a hydrodynamic pressure of at least 750 mm H2O applied to the valve for at least 5 seconds.2. The urological device of claim 1 , wherein the urinary catheter comprises a Foley catheter and the valve is retained inside of the Foley catheter.3. The urological device of claim 1 , further comprising a housing that is removably insertable into the urinary catheter claim 1 , and the valve is retained inside of the housing.4. The urological device of claim 3 , wherein the housing comprises a distal section that is separable from a proximal section claim 3 , and the valve is retained between the distal section and the proximal section of the housing.5. The urological device of claim 1 , wherein the valve comprises ...

Method of treating incontinence

A method of treating incontinence includes implanting the incontinence treatment device having a sling connected between first and second anchors into a patient, and moving an adjustment device through a channel from a first position to a second position that locates the second anchor between the adjustment device and the sling, thus tightening the sling by shortening an effective distance of the device between the first and second anchors.

MULTI-LUMEN DRUG DELIVERY DEVICES

Drug delivery devices () are provided herein and include an elongated, elastic body () extending between a first end and a second end, wherein the elastic body comprises a water permeable wall structure () having defining an elongated drug reservoir lumen () extending between the first and second ends. One or more secondary lumens () are structured (e.g., positioned, sized, shaped, and optionally filled) to be effective to retard or prevent in vivodiffusion of (i) water into the drug reservoir lumen and/or (ii) solubilized drug out of the drug reservoir lumen. 1. A drug delivery device for controlled release of drug into a patient comprising:an elongated, elastic body extending between a first end and a second end, wherein the elastic body comprises a outer wall structure having an external surface and an inner surface, the outer wall structure having an annular shape and extending between the first and second ends;an arcuate interior wall structure extending across the annulus of the outer wall structure and connected to the interior surface of the outer wall structure in a manner to define within the annulus an elongate drug reservoir lumen, which has a non-cylindrical cross-sectional shape, on one side of the interior wall structure and a secondary lumen on a second side of the interior wall structure;a drug payload disposed in the drug reservoir lumen, the drug payload comprising a drug,wherein the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and a coiled retention shape.2. The device of claim 1 , wherein the outer wall structure is water permeable.3. (canceled)4. The device of claim 1 , wherein the outer wall structure adjacent the drug reservoir lumen comprises two different materials of construction claim 1 , of which a first material is impermeable to the drug when the drug is in solution and a second material which is permeable to the drug when the drug is in solution.5. The ...

IMPLANTABLE DEVICE FOR INTERNAL URINARY CONTROL

An apparatus for assisting the discharging of urine from a natural urinary bladder of a patient is disclosed. The apparatus comprises an implantable expandable member configured to be implanted inside of the urinary bladder, and an implantable control device for controlling the volume of the expandable member. The control device is configured to generate a pressure in the implantable expandable member exceeding 50 cm water pressure to assist the discharging of urine. 185.-. (canceled)86. An apparatus for assisting the discharging of urine from a natural urinary bladder of a patient , the apparatus comprising:an implantable expandable member configured to be implanted inside of the urinary bladder,an implantable control device for controlling the volume of the expandable member,wherein the implantable control device is configured generate a pressure in the implantable expandable member exceeding 50 cm water pressure thereby assisting the discharging of urine.87. The apparatus according to claim 86 , further comprising:an implantable hydraulic fluid reservoir, andan implantable conduit connecting the implantable hydraulic fluid reservoir to the expandable member.88. The apparatus according to claim 87 , wherein the implantable control device comprises a pump for pumping a hydraulic fluid from the implantable hydraulic fluid reservoir to the expandable member.89. The apparatus according to claim 87 , wherein the implantable hydraulic fluid reservoir is configured to be implanted in the abdomen of the patient claim 87 , and wherein the implantable conduit is configured to connect the implantable hydraulic fluid reservoir to the implantable expandable member claim 87 , passing the wall of the natural urinary bladder.90. The apparatus according to claim 86 , further comprising an implantable wireless energy receiver connected to the implantable control device.91. The apparatus according to claim 86 , further comprising an implantable electrical switch configured to be ...

Implantable device for internal urinary control

An apparatus for treating a urinary retention of a patient by discharging urine from a mammal urinary bladder through a mammal urethra. The apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient, a control device adapted to control the volume of the expandable member for emptying the mammal urinary bladder, and an implantable restriction devices adapted to close each ureter of a patient when discharging urine from the urinary bladder. 185.-. (canceled)86. An apparatus for treating a urinary retention of a patient by discharging urine from a mammal urinary bladder through a mammal urethra , the apparatus comprising:an expandable member adapted to be implanted inside the urinary bladder of the patient,a control device adapted to control the volume of the expandable member for emptying the mammal urinary bladder, andan implantable restriction devices adapted to close each ureter of a patient when discharging urine from the urinary bladder.87. The apparatus according to claim 86 , wherein the control device comprises an internal control unit comprising a subcutaneously placed switch.88. The apparatus according to claim 86 , wherein the control device comprises at least one of a motor or a pump.89. The apparatus according to claim 86 , wherein the control device comprises an internal control operable from outside of the patient's body.90. The apparatus according to claim 86 , wherein:the expandable member is hydraulically controlled and comprises a cavity for hydraulic fluid;the control device comprises an implantable bladder operating reservoir for hydraulic fluid, and whereinthe expandable member and the control device are adapted to be hydraulically connected through the wall of the urinary bladder via an interconnecting device, wherein the interconnecting device comprises an implantable tube to establish hydraulic connection and for transporting the hydraulic fluid between the bladder operating reservoir and the ...

ENHANCED PERFORMANCE SOLUTION FOR TISSUE GRAFTS

The present disclosure describes a treatment composition comprising a nanoparticle composition comprising nanoparticles functionalized with surface amine groups and a crosslinking composition comprising genipin. The disclosure also describes a kit comprising the treatment composition, and instructions for using the kit to crosslink the nanoparticles to a tissue graft. The treatment composition and kit can be used to crosslink nanoparticles to a tissue graft, and the resulting tissue graft can be used to replace defective tissue in a subject in need thereof. 1. A treatment composition comprising a nanoparticle composition comprising nanoparticles functionalized with surface amine groups and a crosslinking composition comprising genipin.2. The treatment composition of claim 1 , wherein the composition has a genipin concentration from about 0.01 mM to about 10 mM.36-. (canceled)7. The treatment composition of claim 1 , wherein the composition further comprises a buffer claim 1 , an antimicrobial agent claim 1 , an anti-inflammatory agent claim 1 , a cell culture media claim 1 , or a combination thereof.89-. (canceled)10. The treatment composition of claim 1 , wherein the nanoparticles have a mean diameter of from about 5 nm to about 100 nm.1112-. (canceled)13. The treatment composition of claim 1 , wherein the nanoparticles are metallic nanoparticles claim 1 , ceramic nanoparticles claim 1 , or polymer nanoparticles.14. (canceled)15. The treatment composition of claim 13 , wherein the metallic nanoparticles are gold nanoparticles.1623-. (canceled)24. The treatment composition of claim 1 , wherein the nanoparticles are functionalized with surface amino groups via addition of 2-mercaptoethylamine.25. (canceled)26. A kit for crosslinking nanoparticles to a tissue graft claim 1 , the kit comprising a nanoparticle composition comprising nanoparticles claim 1 , a functionalization component comprising a ligand having a thiol group and an amine group claim 1 , a crosslinking ...

CLOSE-CELL STRUCTURED STENT, A PREPARATION METHOD AND USE THEREOF

Disclosed herein is a close-cell structured stent which is composed of curved struts that intersect at a crossing angle of 90 to 170 degrees in the longitudinal direction. Methods for making the stent, use of the stent as a vascular stent, an esophagus stent, an intestine stent, a bile conduct stent, or a urinary tract stent, and use of the stent in the manufacture of stent graft for the treatment of abdominal aortic aneurysms are also provided. The stent has both excellent longitudinal flexibility and radial strength. 1. A stent comprising:a plurality of rings coupled together, wherein at least some of the plurality of rings comprise closed cells formed from a plurality of curved struts coupled together, the plurality of curved struts having a first end and a second end opposite the first end, wherein a straight line extends from the first end to the second end, and wherein a curvature of the plurality of curved struts is defined by a deviation of the plurality of curved struts a distance d from the straight line, and wherein d is in the range of 0.01 mm to 0.99 mm.2. The stent of claim 1 , wherein at least some of the plurality of curved struts intersect one another at an angle from 90 to 170 degrees in the longitudinal direction claim 1 , wherein a radial strength of the stent increases when the angle increases.3. The stent of claim 1 , wherein the angle is from 140 to 150 degrees.4. The stent of claim 1 , wherein at least some of the plurality of rings comprise a plurality of peaks circumferentially disposed therearound.5. The stent of claim 1 , wherein at least some of the plurality of curved struts have a cross-section claim 1 , the cross-section being a circle claim 1 , a triangle claim 1 , a square claim 1 , a rectangle claim 1 , a star claim 1 , or an irregular shape.6. The stent of claim 1 , wherein the stent is formed from a biodegradable material or a non-biodegradable material.7. The stent of claim 1 , further comprising a therapeutic agent carried by ...

Implant and implant apparatus

An implant is an implantable device for the treatment of urinary incontinence in women, that is, a device that supports the urethra in a state where the urethra is pulled in a direction such that the urethra is separated from the vaginal wall. The implant includes a pad which can be recovered from a constrained state by a self-recovery force and which has a plate-shaped appearance in the recovered state; and at least one string that passes through the pad to fix the pad in a state where the pad supports the urethra. The pad has a mesh-like shape with a plurality of openings. When the pad is fixed to the living body so as to support the urethra, the string passes through mesh opening of the pad and a fixing portion that is fixed to the living body is provided in one end portion of the string. 1. An implant for treatment of urinary incontinence in women comprising:a pad, the shape of which can be recovered from a constrained state and which has a generally flat, plate-shaped appearance in a recovered state; anda fixing member that passes through the pad to fix the pad to a living body when in use in a state where the pad supports the urethra.2. The implant according to claim 1 ,wherein the pad recovers from a folded state, a rolled-up state or a compressed state by a self-recovery force.3. The implant according to claim 1 ,wherein the pad has a mesh-like configuration, andwherein the fixing member passes through openings in the mesh-like configuration of the pad when the fixing member fixes the pad.4. The implant according to any one of claim 1 , wherein the fixing member is a long object that is flexible.5. The implant according to claim 4 ,wherein a fixing portion that is fixed to the living body is provided in at least one end portion of the long object.6. The implant according to claim 5 ,wherein the fixing portion is a portion that punctures the living body, and the fixing portion of the long object has resistance greater than other portions of the long object ...

Controlled extension stent

The present disclosure relates generally to controlled extension medical stents, and more particularly to controlled extension devices positioned in the body to stent the ureter and facilitate drainage from the kidney to the bladder.

Implant with high vapor pressure medium

An implant delivery system can be configured to deliver an inflatable implant into a bladder via a urethra. The delivery system can comprise an elongate tubular body, an inflation tube and an implant decoupler. The tubular body can comprise a central lumen configured to hold an inflatable implant in an initial un-inflated state for delivery of the implant into the bladder. A method of use can include passing a distal tip of the elongate tubular body into the bladder. The implant can be inflated and released into the bladder.

Systems, Kits and Methods for Inducing Negative Pressure to Increase Renal Function

A method for removing fluid from a patient is provided, the method including: deploying a ureteral stent or ureteral catheter into a ureter of a patient to maintain patency of fluid flow between a kidney and a bladder of the patient; deploying a bladder catheter into the bladder of the patient, wherein the bladder catheter comprises a distal end configured to be positioned in a patient's bladder, a drainage lumen portion having a proximal end, and a sidewall extending therebetween; and applying negative pressure to the proximal end of the bladder catheter to induce negative pressure in a portion of the urinary tract of the patient to remove fluid from the patient. Systems and kits related thereto also are provided. 1: A method for removing fluid from a patient , the method comprising:deploying a ureteral stent or ureteral catheter into a ureter of a patient to maintain patency of fluid flow between a kidney and a bladder of the patient;deploying a bladder catheter into the bladder of the patient, wherein the bladder catheter comprises a distal end configured to be positioned in a patient's bladder, a drainage lumen portion having a proximal end, and a sidewall extending therebetween; andapplying negative pressure to the proximal end of the bladder catheter to induce negative pressure in a portion of the urinary tract of the patient to remove fluid from the patient.2: The method of claim 1 , further comprising deploying a second ureteral stent or second ureteral catheter into a second ureter of the patient to maintain patency of fluid flow between a second kidney and the bladder of the patient.3: The method of claim 1 , wherein the ureteral catheter comprises a drainage lumen having a proximal end claim 1 , a distal end configured to be positioned in at least one of the patient's ureter claim 1 , renal pelvis or kidney claim 1 , and a sidewall extending therebetween; and a retention portion extending radially outwardly from a portion of the distal end of the drainage ...

Method of removing an inflated implant from a bladder

An inflated implant, such as an attenuation device, previously implanted in a urinary bladder can later be removed according to a number of different methods. Preferably, removal is accomplished transurethrally. In one embodiment, removal is accomplished by reducing the inflated implant from an enlarged profile to a reduced profile so that it may be withdrawn transurethrally by a removal system. The removal system can be configured differently depending upon whether reduction from the enlarged profile to the reduced profile is accomplished by deflation, compression, and/or other ways.

IMPROVED ABSORBABLE PATCH, IN REINFORCED PGA, FOR THE REPLACEMENT OF A PORTION OF BLADDER WALL FOLLOWING PARTIAL CYSTECTOMY

A patch () for the replacement of a portion of bladder wall, following partial cystectomy, comprises a textile () derived from a PGA yarn and provided with a star-shaped support frame, flexible and harmonic, formed by a plurality of radial strips () manufactured by injection of a PGA/PLA copolymer, the patch () being suitable for making autologous fibrous capsule cells, generated by the process of tissue reconstruction, grow thereon after its insertion inside the patient. 111-. (canceled)1211112123. Absorbable self-supporting patch () , ready for use without previous cell coverage , for the replacement of a portion of bladder wall after partial cystectomy and following the covering of said patch () by growing autologous fibrous capsule cells generated by the process of tissue reconstruction after the insertion of said patch () inside the patient , said patch () comprising an absorbable textile () , preferably texturised , made with monofilament or multifilament yarns deriving from PGA fibres , said patch () being characterised in that said textile () is supported by a non porous heat-formed planar frame , flexible and harmonic , formed by a plurality of heat-formed radial reinforcement strips () of PGA/PLA copolymer , said strips extending radially outwards from the centre of said frame and being substantially rigid yet elastic and flexible so as to be slightly curved manually by the surgeon during the operation.1312. Patch () according to wherein the yarn of the textile () has a size comprised between 50 and 200 deniers.1412. Patch () according to wherein the textile () is a warp knitted textile.1512. Patch () according to wherein the yarn of the textile () is a multifilament of the 75 denier/30 filament type.1612. Patch () according to wherein the textile () is a texturized textile.1712. Patch () according to wherein the profile of the textile () is circular claim 12 , preferably having a diameter comprised between 3 and 5 cm.1812. Patch () according to wherein ...

Stent and Method of Use

A urinary stent includes ends for deployment in the kidney and bladder, respectively, that are non-coplanar. The bladder end of the stent includes a luminary groove, covered by a sleeve of materials softer than the remainder of the stent, allowing urine at sufficient pressures to pass out from the stent, between the stent and the sleeve. The bladder end of the stent adapts its shape according to respiratory changes in the length of the stent. This shape change also prevents or reduces stent related pain. 1. A stent comprising:a body including oppositely disposed first and second curled ends, the first curled end extending along a first plane and the second curled end extending along a second plane, the first and second planes at different orientations with respect to each other;wherein the body is tubular and includes:an outer surface;an interior lumen;the second curled end of the body including a groove extending through the body into the lumen, from the outer surface of the body;a sleeve extending at least partially along the groove over the body;and wherein the sleeve is of a material of a lower durometer than the body of the stent.2. The stent of claim 1 , wherein the different orientations of the first and second planes with respect to each other include angles ranging from approximately 60 degrees to approximately 120 degrees.3. The stent of claim 1 , wherein the different orientations of the first and second planes with respect to each other include a perpendicular orientation.4. The stent of claim 1 , wherein the first curled end and the second curled end are moveable between a curled position and a partially uncurled position to accommodate the respiration of the user.5. The stent of claim 1 , wherein the second curled end is configured for placement at least partially in the bladder.6. (canceled)7. The stent of claim 1 , wherein the sleeve extends beyond the ends of the groove.8. (canceled)9. The stent of wherein the sleeve is of a material that when ...

UROLOGICAL DEVICE

A urological device comprises a urological valve for location in the bladder of a patient and a valve support stem for location in the urethra of a patient. The valve has a normally closed configuration to prevent flow from the bladder and an open configuration for fluid flow through the valve. The valve is automatically movable from the closed configuration to the open configuration in response to a pre-set hydrodynamic pressure applied for a pre-set time. In one case the valve has a plurality of valve leaflets with a region of co-aption between the valve leaflets. In the normally closed configuration the valve leaflets are engaged at the region of co-aption and in the open configuration the leaflets are separated at the co-aption region for fluid flow through the valve.

STENT PUSHER ASSEMBLY

Provided is a stent pusher assembly () for positioning a ureteral stent (), the stent pusher assembly having an inner () and outer stent pusher (). The stent pusher assembly positions the ureteral stent in a patient's kidney and bladder without a bladder fixing portion () of the stent entering a ureteral passage-way, thereby minimizing irritation to the patient. 1. A method for positioning a ureteral stent in a kidney , ureteral passageway and bladder of a patient using a stent pusher assembly having an inner and outer pusher , the ureteral stent including a bladder portion configured to be positioned in the bladder , a kidney portion configured to be positioned in the kidney and the ureteral passageway , and at least one tether coupled to the bladder portion and the kidney portion , the method including:advancing a guidewire into the bladder, the ureteral passageway and the kidney;advancing the kidney portion and bladder portion over the guidewire;advancing the outer pusher over the guidewire;advancing the outer pusher along the guidewire until a second end of the outer pusher abuts a first end of the bladder portion;advancing the outer pusher towards the kidney to advance the bladder portion and kidney portion until the kidney portion is substantially positioned in the ureteral passageway;advancing the inner pusher over the guidewire, through a lumen of the outer pusher and through a lumen of the bladder portion until a second end of the inner pusher abuts a second end of the kidney portion; andadvancing the inner pusher towards the kidney to advance the kidney portion such that the second end of the kidney portion is disposed in the ureteral passageway and a first end of the kidney portion is disposed in the kidney.2. The method according to claim 1 , wherein the kidney portion and bladder portion are in respective restrained shapes when the guidewire extends through the kidney portion and bladder portion.3. The method according to claim 1 , further including: ...

ARTIFICIAL BLADDER SYSTEM

An artificial bladder system including an implantable bladder, a valve, a number of sensors, and an alert mechanism. The implantable bladder includes an outer wall forming a chamber for collecting urine of a user, the outer wall including inflow openings and an outflow opening. The valve is integrated with the outflow opening to selectively allow urine to flow from the chamber through the outflow opening. The sensors are configured to detect a urine level in the chamber. The alert mechanism is configured to generate a sensory output to alert the user that the bladder should be emptied upon detection of the urine level in the chamber by one of the sensors. 1. An artificial bladder system comprising:an implantable bladder including an outer wall forming a chamber for collecting urine of a user, the outer wall including inflow openings and an outflow opening;a valve integrated with the outflow opening to selectively allow urine to flow from the chamber through the outflow opening; anda plurality of sensors including a first sensor positioned in the bladder to detect a first urine level and a second sensor positioned in the bladder to detect a second urine level greater than the first urine level, the first sensor being configured to generate a signal representing detection of the first urine level, the second sensor being configured to generate a signal representing detection of the second urine level,the valve being configured to be opened via input from the user and automatically upon detection of the second urine level in the chamber by the second sensor.2. The artificial bladder system of claim 1 , the first urine level being approximately sixty percent and the second urine level being approximately ninety percent.3. The artificial bladder system of claim 1 , one of the plurality of sensors being positioned in the middle of the chamber to detect an approximately fifty percent urine level in at least two different orientations of the bladder.4. The artificial ...

Methods and systems for performing a medical procedure

Method and system for treating a patient using a compressible, pressure-attenuating device. According to one embodiment, the system is used to treat urinary tract disorders and can include one or more of an access device, a delivery device, a pressure-attenuating device, and a removal device. The access device may be used to create a passageway to an anatomical structure, such as the patient's bladder. The delivery device may be inserted through the passageway created by the access device and may be used to deliver the pressure-attenuating device to the anatomical structure. The removal device may be inserted through the passageway created by the access device and may be used to view the bladder and/or to capture, to deflate and to remove the pressure-attenuating device.

Close-cell structured stent, a preparation method and use thereof

Disclosed herein is a close-cell structured stent which is composed of curved struts that intersect at a crossing angle of 90 to 170 degrees in the longitudinal direction. Methods for making the stent, use of the stent as a vascular stent, an esophagus stent, an intestine stent, a bile conduct stent, or a urinary tract stent, and use of the stent in the manufacture of stent graft for the treatment of abdominal aortic aneurysms are also provided. The stent has both excellent longitudinal flexibility and radial strength.

Device, systems and methods for treatment of neurogenic bladder

Embodiments of the invention provide apparatus, systems and methods for stimulating tissue in the urinary tract to initiate or facilitate urination. One embodiment provides an external urinary sphincter stimulation (EUSS) catheter for stimulating the external urinary sphincter (EUS), where the EUSS catheter includes nerve stimulation electrodes (NSES) for delivering current to nerves within or around the EUS in order to relax the EUS prior to urination. Other embodiments provide a system for stimulating the EUS including the EUSS catheter and a controller operatively coupled to the EUSS catheter, where the controller includes a pulse generator for delivering current to the NSES. Other embodiments provide methods for positioning the EUSS catheter in the patient's body including in the EUS using a urethral approach. Embodiments of the invention are particularly useful for initiating and/or controlling urination for patients who have lost the ability to voluntarily urinate due to neurogenic bladder dysfunction.

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis includes a casing defining an enclosure for containing the urine of a patient; the casing being made of a PGA fiber fabric; two first connectors connected to the casing and connectable to the ureters of the patient to allow the entrance of the urine into the enclosure; a second connector connected to the casing and connectable to the patient's urethra to allow the outflow of the urine from the enclosure; a catheter inserted in the enclosure through the second connector and including a duct and an expandable element in fluid communication with the duct. 1. An orthotopic artificial bladder endoprosthesis comprising:a casing defining an enclosure for containing the urine of a patient; said casing being made of a PGA fiber fabric;two first connectors connected to the casing and connectable to the ureters of the patient to allow the entrance of the urine into the enclosure;a second connector connected to the casing and connectable to the patient's urethra to allow the outflow of the urine from the enclosure;a catheter inserted in the enclosure through said second connector and comprising a duct and an expandable element in fluid communication with said duct;{'sup': 3', '3, 'said expandable element has, at a completely extended configuration, a volume comprised between 200 cmand 500 cm, the expandable element being configured to widen for supporting the casing during the formation of muscolo-fibrous tissue during a resorption step.'}2. The endoprosthesis according to claim 1 , wherein said catheter is a catheter of Foley type.3. The endoprosthesis according to claim 1 , wherein the expandable element of the catheter is made of polyurethane.4. The endoprosthesis according to claim 1 , wherein said catheter is externally covered with a layer of turbostratic pyrolytic carbon.5. The endoprosthesis according to claim 1 , wherein said catheter comprises a free end shaped obliquely.6. The endoprosthesis according to claim 1 , ...

METHODS AND MATERIALS FOR TREATING URINARY CALCULI

This document relates to methods and materials for treating urinary calculi. For example, ureteral orifice devices and methods for using ureteral orifice devices to treat urinary calculi present within a mammal (e.g., a human) are provided. 1. A ureteral orifice device comprising a distal portion and a proximal portion and defining a channel that extends along a longitudinal axis of said ureteral orifice device , wherein at least an outer portion of said distal portion is configured to extend laterally away from said longitudinal axis to engage an inner wall of a ureter when said ureteral orifice device is implanted within a mammal , and wherein said channel is configured to allow urine to flow in an impeded manner through said ureteral orifice device from a kidney of said mammal to a bladder of said mammal when said ureteral orifice device is implanted within said mammal.2. (canceled)3. The ureteral orifice device of claim 1 , wherein at least a portion of said proximal portion extends into said bladder when said ureteral orifice device is implanted within said mammal.46-. (canceled)7. The ureteral orifice device of claim 1 , wherein said proximal portion comprises an actuator configured to extend said outer portion of said distal portion laterally away from said longitudinal axis to engage said inner wall of said ureter when said ureteral orifice device is implanted within said mammal.8. The ureteral orifice device of claim 1 , wherein said proximal portion claim 1 , said distal portion claim 1 , or both said proximal portion and said distal portion comprise one or more physical or radiopaque markers.913-. (canceled)14. The ureteral orifice device of claim 1 , wherein said ureteral orifice device comprises an anti-inflammatory agent claim 1 , a smooth muscle relaxing agent claim 1 , or analgesic agents.1518-. (canceled)19. A method for treating a mammal having a urinary calculus claim 1 , wherein said method comprises implanting a ureteral orifice device into a ...

Methods and systems for performing a medical procedure

Method and system for treating a patient using a compressible, pressure-attenuating device. According to one embodiment, the system is used to treat urinary tract disorders and comprises an access device, a delivery device, a pressure-attenuating device, and a removal device. The access device may be used to create a passageway to an anatomical structure, such as the patient's bladder. The delivery device may be inserted through the passageway created by the access device and may be used to deliver the pressure-attenuating device to the anatomical structure. The removal device may be inserted through the passageway created by the access device and may be used to view the bladder and/or to capture, to deflate and to remove the pressure-attenuating device.

Method of bladder augmentation with modified ileal segment and biologically compatible tissue

A method of augmenting a bladder including incising a native bladder to form an incised native bladder, implanting a tissue flap, comprising a bladder-expansion portion connected to a tubular portion; and suturing the bladder-expansion portion to an edge of the incised native bladder. The method forms an augmented bladder with a volume capacity that is 100%-250% larger than a volume capacity of the native bladder. The tissue flap may be a modified ileal segment or a biologically compatible tissue flap. The biologically compatible tissue flap having a biocompatible scaffold comprising a collagen mesh, which is coated by a biochemical factor, a cell derived matrix, and/or a synthetic biocompatible polymer. The biologically compatible tissue flap is configured with the bladder-expansion portion and a tubular portion.

UROLOGICAL DEVICE HAVING A BLADDER RETAINER AND A VALVE

A urological device includes a valve support stem, a bladder retainer, and a urological valve. The valve support stem is adapted for placement in a urethra of a user and extends between a proximal end and a distal end. The bladder retainer is adapted for placement in a bladder of the user. The bladder retainer is connected to the valve support stem at a support stem location between the proximal end and the distal end of the valve support stem. The bladder retainer is formed as a wall of material extending radially outwardly from the valve support stem, with a proximal surface of the wall forming an acute angle relative to the valve support stem. The urological valve is disposed in the bladder retainer at a location proximal to the support stem location and proximal to the proximal surface of the wall. 1. A urological device comprising:a valve support stem adapted for placement in a urethra of a user, the valve support stem extending between a proximal end and a distal end;a bladder retainer adapted for placement in a bladder of the user, the bladder retainer is connected to the valve support stem at a support stem location between the proximal end and the distal end of the valve support stem, the bladder retainer is formed as a wall of material extending radially outwardly from the valve support stem, with a proximal surface of the wall forming an acute angle relative to the valve support stem; anda urological valve disposed in the bladder retainer at a location proximal to the support stem location and proximal to the proximal surface of the wall, the urological valve including a movable leaflet;wherein the movable leaflet of the urological valve has a closed configuration adapted to prevent a flow of urine through the valve support stem and the movable leaflet of the urological valve is adapted to respond to a pressure and move to an open configuration adapted to allow a flow of urine through the valve support stem.2. The urological device of claim 1 , wherein ...

METHODS AND SYSTEMS FOR CONTROLLING BODY PARTS AND DEVICES USING IPSILATERAL MOTOR CORTEX AND MOTOR RELATED CORTEX

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal. 1. A method for controlling a body part , comprising the steps of:sensing a plurality of signals from a hemisphere of a brain;translating the sensed signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain; andmanipulating the body part in response to the command signal.2. The method of claim 1 , wherein the plurality signals is selected from the group consisting of electrocorticographic (ECoG) signals claim 1 , electroencephalography (EEG) signals claim 1 , local field potentials claim 1 , single neuron signals claim 1 , (MEG) magnetoencephalography signals claim 1 , mu rhythm signals claim 1 , beta rhythm signals claim 1 , low gamma rhythm signals claim 1 , and high gamma rhythm signals.3. The method of claim 2 , wherein the ECoG claim 2 , EEG claim 2 , local field potentials claim 2 , and MEG signals include at least one of mu rhythm signals claim 2 , beta rhythm signals claim 2 , low gamma rhythm signals claim 2 , and high gamma rhythm signals.4. The method of claim 1 , wherein the plurality of signals is sensed from one of the primary motor cortex claim 1 , the premotor cortex claim 1 , the frontal lobe claim 1 , the parietal lobe claim 1 , the temporal lobe claim 1 , and the occipital lobe of the brain.5. The method of claim 1 , wherein the command signal is communicated to one of a robotic device claim 1 , a transportation device claim 1 , and a prosthetic control device.6. The method of claim 5 , wherein the prosthetic control device is an external robotic ...

Personalized prosthesis and methods of use

A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed.

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis includes two portions connected to each other; each portion including a respective resorbable cap made of a PGA fiber fabric and a respective frame, associated with the cap, obtained by means of PGA/PLA copolymer; the portions being connected together in order to define a closed enclosure. 1. An orthotopic artificial bladder endoprosthesis comprising two portions connected to each other;each portion comprising a respective resorbable cap made of a PGA fiber fabric and a respective frame, associated with said cap, obtained by means of PGA/PLA copolymer;said portions being connected together to define a closed enclosure.2. The endoprosthesis according to claim 1 , wherein said portions are connected together by means of resorbable suture.3. The endoprosthesis according to claim 1 , wherein said caps are mutually connected at their edges.4. The endoprosthesis according to claim 1 , wherein each frame comprises a plurality of arms arranged as a star and defining a dome-like profile.5. The endoprosthesis according to claim 4 , wherein the arms of a first portion are fixed to the arms of a second portion.6. The endoprosthesis according to claim 4 , wherein the arms of the first portion are separated from the arms of the second portion.7. The endoprosthesis according to claim 1 , wherein the fabric of said caps is warp knitted fabric.8. The endoprosthesis according to claim 1 , wherein the PGA/PLA copolymer consists of 30% PGA and 70% PLA.9. The endoprosthesis according to claim 1 , wherein the thickness of the fabric is between 0.1 mm and 2 mm.10. The endoprosthesis according to claim 1 , wherein the fabric is obtained with a thread having a density comprised between 50 and 200 denier.11. The endoprosthesis according to claim 1 , wherein the fabric of said caps is textured fabric.12. The endoprosthesis according to claim 1 , wherein the thickness of the fabric is between 0.3 mm and 0.6 mm.13. The endoprosthesis according to ...

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis includes a casing made of a PGA fiber fabric; the casing having two first connectors for the connection with the ureters of a patient and a further connector for the connection with the urethra of a patient; an inflatable element inserted in the casing; the inflatable element being switchable between an inflated configuration, in which it supports and maintains in position the casing, and a deflated configuration. 1. An orthotopic artificial bladder endoprosthesis comprising:a casing made of a PGA fiber fabric; the casing having two first connectors for the connection with the ureters of a patient and a second connector for the connection with the urethra of a patient; andan inflatable element inserted in the casing and being independent of the casing; the inflatable element being switchable between an inflated configuration, in which the inflatable element supports and maintains in position the casing, and a deflated configuration.2. The endoprosthesis according to claim 1 , wherein the inflatable element has an external surface covered with turbostratic pyrolytic carbon.3. The endoprosthesis according to claim 1 , wherein the inflatable element has a substantially spherical shape in the inflated configuration.4. (canceled)5. The endoprosthesis according to claim 1 , wherein the inflatable element has a valve for introducing and extracting a fill fluid.6. The endoprosthesis according to claim 5 , wherein the valve is independent of the first connectors and/or the second connector.7. The endoprosthesis according to claim 1 , wherein the inflatable element is constituted by a multilayer silicone membrane.8. The endoprosthesis according to claim 2 , wherein the inflatable element has a valve for introducing and extracting a fill fluid.9. The endoprosthesis according to claim 8 , wherein the valve is independent of the first connectors and/or the second connector.10. The endoprosthesis according to claim 3 , wherein the ...

Delivery system having stent retention structure

A drainage stent delivery system including an elongate shaft of a medial device, a drainage catheter or stent, and an interference fit member for selectively coupling the drainage stent to the elongate shaft. The drainage stent is selectively coupled to a distal portion of the elongate shaft by an interference fit between the interference fit member and the drainage stent such that axial movement of the elongate shaft relative to the drainage stent moves the interference fit member from a first position in which the interference fit member is engaged with the drainage stent and forms an interference fit with the drainage stent to a second position in which the interference fit member is disengaged from the drainage stent.

DEVICE FOR PRINTING LUMEN TISSUE CONSTRUCT, METHOD FOR USING THE SAME AND 3D BIOPRINTER

The present disclosure relates to a device for printing lumen tissue construct, a method for using the same and 3D bioprinter. Wherein, the device includes a spray head assembly for printing a biological construct; and a bioprinting platform for supporting a lumen tissue, and for carrying a biological construct printed by the spray head assembly, and for applying the biological construct to an inner surface of the lumen tissue. The device for printing lumen tissue construct of the present disclosure provides the spray head assembly and the bioprinting platform, and the spray head assembly applies the biological construct onto the inner surface of the lumen tissue by the bioprinting platform, to avoid such problems as recurrence of thrombus and restenosis of a lumen after the lumen tissue has been implanted for a long time, thereby improving the biological reliability of the lumen tissue. 1. A device for printing lumen tissue construct , comprising:{'b': '1', 'a spray head assembly () for printing a biological construct; and'}{'b': 2', '1, 'a bioprinting platform () for supporting a lumen tissue, and for carrying a biological construct printed by the spray head assembly (), and for applying the biological construct to an inner surface of the lumen tissue.'}21. The device according to claim 1 , wherein the spray head assembly () comprising:{'b': '125', 'a bio-ink container () for containing bio-ink;'}{'b': '111', 'a medical adhesive container () for containing medical adhesive; and'}{'b': 125', '111, 'a nozzle configured to alternatively communicate with the bio-ink container () and the medical adhesive container ().'}31. The device according to claim 1 , wherein the spray head assembly () comprising:{'b': '11', 'a medical adhesive spray head () for applying medical adhesive to a surface of the biological construct; and'}{'b': 12', '2, 'a bio-ink spray head () for providing bio-ink to the bioprinting platform () so as to print the biological construct.'}411. The ...

DRUG DELIVERY DEVICE WITH INTRAVESICAL TOLERABILITY

Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern. 1. An intravesical drug delivery device , comprising:an elongated elastic body comprising a drug reservoir lumen defined therein; anda drug formulation disposed within the drug reservoir lumen, the drug formulation comprising a drug which comprises a kinase inhibitor,wherein the elongated elastic body has a coiled retention shape having (i) dimensions that provide intravesical mobility and prevent voiding of the device through the urethra, and (ii) a maximum dimension in any direction of 6 cm or less when in an uncompressed state, andwherein the device exerts a maximum acting force less than 1 N when the device is compressed from the retention shape to a shape having a maximum dimension in any direction of 3 cm or less.2. The device of claim 1 , wherein the elongated elastic body comprises a silicone tube which comprises one or more apertures extending through a sidewall of the silicone tube claim 1 , and wherein the device is configured to provide release of the drug through the one or more apertures claim 1 , driven at least in part by an osmotic pressure in the drug reservoir lumen.3. The ...

METHODS AND SYSTEMS FOR PERFORMING A MEDICAL PROCEDURE

Method and system for treating a patient using a compressible, pressure-attenuating device. According to one embodiment, the system is used to treat urinary tract disorders and comprises an access device, a delivery device, a pressure-attenuating device, and a removal device. The access device may be used to create a passageway to an anatomical structure, such as the patient's bladder. The delivery device may be inserted through the passageway created by the access device and may be used to deliver the pressure-attenuating device to the anatomical structure. The removal device may be inserted through the passageway created by the access device and may be used to view the bladder and/or to capture, to deflate and to remove the pressure-attenuating device. 120.-. (canceled)21. A delivery device for use in delivering a therapeutic and/or diagnostic object to an anatomical structure within a patient , the delivery device comprising:(a) a housing;(b) a tube extending from a distal end of the housing, the tube having a proximal end, a distal end, and at least one longitudinal channel;(c) a first fluid supply, the first fluid supply comprising a volume of a first fluid;(d) a second fluid supply, the second fluid supply comprising a volume of a second fluid; and(e) a connection system, the connection system connecting each of the first fluid supply and the second fluid supply to the at least one longitudinal channel of the tube.22. The delivery device as claimed in wherein the housing is a gun-shaped housing comprising a barrel portion and a handle portion claim 21 , the tube extending from a distal end of the barrel portion.23. The delivery device as claimed in wherein the barrel portion comprises a first opening and a second opening claim 22 , the first opening receiving the first fluid supply claim 22 , the second opening receiving the second fluid supply.24. The delivery device as claimed in wherein the first fluid supply is a first syringe and wherein the second fluid ...

BRAIDED STENT AND METHOD OF MANUFACTURING A BRAIDED STENT

A stent may be actuatable between a delivery configuration and a deployed configuration. A stent may include one or more interwoven filaments each including a cross-sectional profile having at least one flattened portion. A flattened portion of a first filament portion of the one or more filaments may be positioned in contact with a flattened portion of a second filament portion of the one or more filaments. 1. A stent actuatable between a delivery configuration and a deployed configuration comprising:one or more interwoven filaments each including a cross-sectional profile having at least one flattened portion,wherein a flattened portion of a first filament portion of the one or more filaments is positioned in contact with a flattened portion of a second filament portion of the one or more filaments.2. The stent of claim 1 , wherein the flattened portion of the first filament portion of the one or more filaments is fixedly attached to the flattened portion of the second filament portion of the one or more filaments.3. The stent of claim 2 , wherein the flattened portion of the first filament portion of the one or more filaments is welded to the flattened portion of the second filament portion of the one or more filaments.4. The stent of claim 1 , wherein the flattened portion of the first filament portion of the one or more filaments includes a first flat surface and the flattened portion of the second filament portion of the one or more filaments includes a second flat surface claim 1 , the first flat surface being oriented facing the second flat surface.5. The stent of claim 4 , wherein the first flat surface extends less than half way around a circumference of the first filament portion of the one or more filaments and the second flat surface extends less than half way around a circumference of the second filament portion of the one or more filaments.6. A method of manufacturing a stent claim 4 , comprising:interweaving one or more filaments around a stent ...

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis includes a casing made of a PGA fiber fabric; the casing having two first connectors for the connection with the ureters of a patient and a second connector for the connection with the urethra of a patient; a support element being inserted in the casing; the support element being switchable between an extended configuration, in which it supports and maintains in position the casing, and a retracted configuration. 1. An orthotopic artificial bladder endoprosthesis comprising:a casing made of PGA fiber fabric, the casing having two first connectors for the connection with the ureters of a patient and a second connector for the connection with the urethra of a patient; characterized in that it also comprises{'b': '6', 'i': 'b', 'a support element inserted in the casing, the support element being deformable to pass from an extended configuration, in which the support element supports and maintains in position the casing, to a retracted configuration and vice versa, the support element comprising a plurality of arms, each having a first and a second end; the arms being constrained to each other at the first and second ends ().'}23-. (canceled)4. The endoprosthesis according to claim 1 , wherein claim 1 , in the restricted configuration claim 1 , the arms have substantially rectilinear form and claim 1 , in the extended configuration claim 1 , the arms are curved according to a mutual moving-apart expansion.5. The endoprosthesis according to claim 1 , wherein the arms are arranged parallel to each other and around a central axis (C) and are angularly equidistant in a manner such that the support element has an axially-symmetric configuration.6. The endoprosthesis according to claim 1 , wherein claim 1 , in the restricted configuration claim 1 , the distance between the first and the second ends of the arms is maximum and claim 1 , in the extended configuration claim 1 , the distance between the first and the second ends of ...

METHODS AND SYSTEMS FOR CONTROLLING BODY PARTS AND DEVICES USING IPSILATERAL MOTOR CORTEX AND MOTOR RELATED CORTEX

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

BISTABLE SPRING CONSTRUCTION FOR A STENT AND OTHER MEDICAL APPARATUS

The present invention is directed to bistable cells and their use in devices, particularly medical devices such as stents, clamps and valves. An expandable stent formed of a plurality of bistable cells is described. The stent has two or more stable configurations, including a first stable configuration with a first diameter and a second stable configuration with a second, larger diameter. A valve comprising a bistable cell for use in eliminating incontinence is also disclosed. 120-. (canceled)21. A bistable valve comprising:1) a conduit;2) a stop surface extending across an interior of the conduit, the stop surface having an opening within; the first end in communication with a trigger,', 'the trigger supported by a support emerging from an inner wall of the conduit,', 'the second end anchored to the stop surface;, 'a substantially arcuate flexible member having a first end and a second end,'}, '3) bipositional unit cell, the unit cell including'}4) a valve closure member.22. The bistable valve of claim 21 , wherein the flexible member has a first position corresponding to a closed position and a second position corresponding to an open position.23. The bistable valve of claim 21 , wherein the valve closure member actuates between open and closed position by the flexible member.24. The bistable valve of claim 21 , wherein the valve closure member closes the opening in the stop surface when the flexible member is in the closed position.25. The bistable valve of claim 21 , wherein the valve closure member opens the opening in the stop surface when the flexible member is in the opened position.26. The bistable valve of claim 21 , wherein the conduit is opened by triggering the trigger to allow the flexible member to move between the closed position and the opened position.27. The bistable valve of claim 21 , wherein the conduit is closed by triggering the trigger to allow the flexible member to move between the opened position and the closed position.28. The bistable ...

Ureteral stent

In some embodiments, a ureteral stent includes an elongate member having a first portion and a second portion, which is coupled to the first portion. The first portion of the elongate member is configured to be disposed within a kidney of a patient. The second portion of the elongate member, which has a sidewall that defines a lumen, is configured to deliver fluid from a first location of the sidewall of the second portion to a second location of the sidewall of the second portion via capillary action. The second portion of the elongate member is configured to be disposed within at least one of a bladder and a ureter of the patient.

Urethral device

An indwelling urethral device is described that includes an elongated tubular member extending along a longitudinal axis (L) from a distal inlet end portion, via an intermediate portion, to a proximal outlet end portion, the tubular member defining a lumen extending along the longitudinal axis between the distal inlet end portion and the proximal outlet end portion, the distal end portion of the elongated tubular member comprising a plurality of urine inlet openings, at least a part of the distal end portion being preconfigured to be reversibly transformable between a linear state for passage through the urethra when inserted there through and a preconfigured coiled state for anchored receipt within the bladder in the use position. The plurality of urine inlet openings is provided on the interior spiral section and urine inlet openings are absent on the exterior spiral section.

EXPANDER OF ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

A description is given of a deformable and expandable element, or expander, for internal support for an orthotopic artificial bladder endoprosthesis in a textile of biodegradable biocompatible material, characterised in that the expander has a substantially hollow shape, made in medical grade silicone elastomer, and provided with a conduit for injecting in its interior a fluid so as to change from a non-expanded configuration to an expanded configuration, the conduit being integral with a one-way check valve applied on the expander. 1100. An orthotopic artificial bladder endoprosthesis in a textile of biodegradable biocompatible material comprising an inner support constituted by a deformable and expandable element , or “expander” , () apt to act , when in expanded form , as inner support ,{'b': 100', '21, 'wherein said expander () is substantially in the form of a balloon, internally hollow, made in medical-grade silicone, and provided with a conduit () for injecting into an interior of the expander, by means of a syringe, a liquid so as to change from a non-expanded configuration to an expanded configuration,'}{'b': 21', '20, 'said conduit () being formed in, and integral with, a one-way check valve () applied on said expander.'}2100. The endoprosthesis according to claim 1 , wherein at least the outer surface of said expander element () is covered with a microfilm of pyrolytic turbostratic carbon.3100. The endoprosthesis according to claim 1 , wherein said silicone of said expander element () is elastomeric and comprises copolymers of dimethylsiloxane and methylvynilsiloxane.4100. The endoprosthesis according to claim 1 , wherein said medical-grade silicone of said expander element () comprises radio-opacity additives.5100. The endoprosthesis according to claim 1 , wherein said expander element () has a volume of approximately 300 cc in a non-expanded condition claim 1 , and a volume up to 600 cc in an expanded condition.61002. The endoprosthesis according to ...

PIXEL ARRAY MEDICAL SYSTEMS, DEVICES AND METHODS

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject. 1. A method , comprising:identifying a donor site on a subject;removing a portion of the epidermis within the donor site;harvesting a plurality of dermal plugs within the donor site;forming an injectable filler by mincing the dermal plugs; andinjecting the injectable filler into a recipient site on the subject, wherein the recipient site is different from the donor site.2. The method of claim 1 , wherein the injectable filler comprises a live autologous dermal matrix (LADMIX) injectable filler.3. The method of claim 2 , wherein the injectable filler comprises live fibroblasts.4. The method of claim 1 , wherein the removing the portion of the epidermis comprises removing the portion of the epidermis in a region of the donor site.5. The method of claim 1 , wherein the removing the portion of the epidermis comprises removing the portion of the epidermis in a plurality of regions of the donor site.6. The method of claim 1 , wherein the removing the portion of the epidermis comprises delaminating the epidermis from the dermis in at least one region of the donor site.7. The method of claim 6 , wherein the delaminating comprises blistering skin.8. The method of claim 6 , wherein the delaminating comprises blistering skin at the donor site.9. The method of claim 6 , wherein the delaminating comprises vibratory shearing.10. The method of claim 9 , wherein the vibratory shearing comprises at least one of vacuum and heat.11. The method of claim 6 , wherein the delaminating comprises superficial injection.12. The method of claim 11 , wherein the superficial injection comprises at least one of saline and anesthetic.13. The method of claim 1 , ...

UROLOGICAL DEVICE ADAPTED FOR PLACEMENT IN A URETHRA OF A USER FOR TREATMENT OF INCONTINENCE

A urological device adapted for placement in a urethra of a user for treatment of incontinence includes a stem, an anchor portion connected to a distal end portion of the stem, a bladder retainer connected to a proximal end of the stem, and a urological valve connected to the proximal end of the stem. The urological valve includes a plurality of movable leaflets connected to and extending in a proximal direction way from the proximal end of the stem. The movable leaflets have an at-rest closed configuration adapted to prevent a flow of urine through the stem, and the movable leaflets are adapted to evert in a distal direction to provide the urological valve with an open configuration adapted to allow urine to flow through the stem. 1. A urological device adapted for placement in a urethra of a user for treatment of incontinence , the urological device comprising:a stem;an anchor portion connected to a distal end portion of the stem;a bladder retainer connected to a proximal end of the stem; anda urological valve connected to the proximal end of the stem, with the urological valve including a plurality of movable leaflets connected to and extending in a proximal direction way from the proximal end of the stem;wherein the movable leaflets have an at-rest closed configuration adapted to prevent a flow of urine through the stem, and the movable leaflets are adapted to evert in a distal direction to provide the urological valve with an open configuration adapted to allow urine to flow through the stem;wherein with the bladder retainer extends away from the stem in a radial direction to an outermost perimeter that is located a proximal distance away from the proximal end of the stem, with the movable leaflets located proximal of a proximal side of the bladder retainer.2. The urological device of claim 1 , wherein the bladder retainer has a proximal side adapted to direct urine toward the urological valve and a distal side adapted to contact tissue of the bladder claim 1 , ...

BIOMIMETIC ARTIFICIAL BLADDER AND METHOD FOR CONTROLLING SAME

An artificial bladder is provided, including: a main body which includes an inlet port, an outlet port, an inner wall that forms a first reservoir portion configured to store urine between the inlet port and the outlet port and that is expandable and contractible. An outer wall forms a second reservoir portion configured to surround at least a partial region of the inner wall. A sensor is attached to the inner wall, has a surface having a wrinkled structure, and is provided so that, when the volume of the first reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes. A control unit is provided to discharge the urine in the first reservoir portion through the outlet port according to a result detected by the sensor. 1. An artificial bladder comprising:a main body which includes an inlet port, an outlet port, an inner wall that forms a first reservoir portion configured to store urine between the inlet port and the outlet port and that is provided to be expandable and contractible, and an outer wall that forms a second reservoir portion configured to surround at least a partial region of the inner wall;a sensor which is attached to the inner wall, has a surface having a wrinkled structure, and is provided so that, when a volume of the first reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes; anda control unit which is provided to discharge the urine in the first reservoir portion through the outlet port according to a result detected by the sensor.2. The artificial bladder of claim 1 , wherein the outer wall has a fluid port provided to introduce a fluid into the second reservoir portion or discharge the fluid from the second reservoir portion to the outside.3. The artificial bladder of claim 2 , further comprising:a fluid storage tank that has a predetermined reservoir;a fluid flow path configured to connect the fluid storage tank and the fluid port; anda pump provided ...

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS

An orthotopic artificial bladder endoprosthesis includes a base obtained with a multi-layered silicone membrane having an external surface and an internal surface both coated with pyrolytic turbostratic carbon; a resorbable cap obtained with a PGA fiber fabric, the base and the cap being connected with each other along respective edges to define a closed enclosure; the base is connectable to the urethra and to the ureters of a patient; the base also being of substantially triangular form. 1. An orthotopic artificial bladder endoprosthesis comprising:a base obtained with a multi-layered silicone membrane having an external surface and an internal surface both coated with pyrolytic turbostratic carbon;a resorbable cap obtained with a PGA fiber fabric, said base and said cap being connected together along respective edges, to define a closed enclosure;wherein said base is connectable to the urethra and to the ureters of a patient; said base also being of substantially triangular form.2. An endoprosthesis according to claim 1 , wherein said base is substantially flattened.3. The endoprosthesis according to claim 1 , wherein said base comprises at least one first connector to connect said base to said urethra and at least two second connectors for connecting said base to said ureters.4. The endoprosthesis according to claim 3 , wherein said second connectors are equidistant from the first connector.5. The endoprosthesis according to claim 1 , wherein the base comprises a band projecting from said edge of the base and made of biocompatible claim 1 , non-resorbable material; said band being fixed to the edge of the cap.6. The endoprosthesis according to claim 5 , wherein said band is firmly comprised between two adjacent layers of the membrane at the external surface of the base.7. The endoprosthesis according to claim 1 , comprising a frame fixed to an internal surface of the cap; said frame comprising a plurality of arms arranged as a star and defining a dome-like ...

METHODS AND SYSTEMS FOR CONTROLLING BODY PARTS AND DEVICES USING IPSILATERAL MOTOR CORTEX AND MOTOR RELATED CORTEX

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal. 1. A method for controlling a body part , comprising the steps of:sensing a plurality of signals from a hemisphere of a brain;translating the sensed signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain; andmanipulating the body part in response to the command signal.2. The method of claim 1 , wherein the plurality signals is selected from the group consisting of electrocorticographic (ECoG) signals claim 1 , electroencephalography (EEG) signals claim 1 , local field potentials claim 1 , single neuron signals claim 1 , (MEG) magnetoencephalography signals claim 1 , mu rhythm signals claim 1 , beta rhythm signals claim 1 , low gamma rhythm signals claim 1 , and high gamma rhythm signals.3. The method of claim 2 , wherein the ECoG claim 2 , EEG claim 2 , local field potentials claim 2 , and MEG signals include at least one of mu rhythm signals claim 2 , beta rhythm signals claim 2 , low gamma rhythm signals claim 2 , and high gamma rhythm signals.4. The method of claim 1 , wherein the plurality of signals is sensed from one of the primary motor cortex claim 1 , the premotor cortex claim 1 , the frontal lobe claim 1 , the parietal lobe claim 1 , the temporal lobe claim 1 , and the occipital lobe of the brain.5. The method of claim 1 , wherein the command signal is communicated to one of a robotic device claim 1 , a transportation device claim 1 , and a prosthetic control device.6. The method of claim 5 , wherein the prosthetic control device is an external robotic ...

URETERAL STENT FOR PLACEMENT IN A KIDNEY AND BLADDER

Provided is a ureteral stent for placement in a bladder, a kidney and a ureteral passageway connecting the bladder and the kidney. The ureteral stent includes a solid bladder portion free of a lumen positionable in the bladder, a tubular kidney portion positionable in the kidney and the ureteral passageway, and a tether connecting the bladder portion and the ureter portion to allow the bladder portion to float in the bladder and to allow a ureter orifice connecting the ureteral passageway to the bladder to move between a compressed state and an uncompressed state. By not having a lumen, the solid bladder portion allows the bladder to have a smaller diameter while maintaining a necessary uncoil force. The smaller diameter also allows the bladder portion to be inserted into a scope alongside a pusher tube, thereby avoiding loading the bladder portion onto a guidewire. 1. A ureteral stent for placement in a bladder , a kidney and a ureteral passageway connecting the bladder and the kidney , the ureteral stent including:a solid bladder portion free of a lumen positionable in the bladder to prevent the bladder portion from migrating into the ureteral passageway;a tubular kidney portion positionable in the kidney and the ureteral passageway, the tubular kidney portion having a ureter portion configured to be positioned in the kidney and the ureteral passageway to place the ureteral passageway in an open state and a resilient fixing portion biased in an unrestrained position to secure the resilient fixing portion in the kidney; anda tether connecting the bladder portion and the ureter portion to allow the bladder portion to float in the bladder and to allow a ureter orifice connecting the ureteral passageway to the bladder to move between a compressed state and an uncompressed state.2. The ureteral stent according to claim 1 , wherein the tether is received in an opening of the ureter portion such that a portion of the tether is outside the ureter portion and a portion is ...

SYSTEM AND METHOD FOR COLLECTING CLINICAL DATA ASSOCIATED WITH A MEDICAL APPARATUS INCLUDING AN IMPLANTABLE DEVICE

A system and method for collecting operation data associated with a medical apparatus including an internal device implanted in a subject and an external device that is magnetically-coupled to and drives the internal device. The medical apparatus may be monitored to obtain raw data associated with the operation of the medical apparatus and one or more calculations may be performed on the raw data, wherein the raw data and/or calculated values may be associated with voiding frequency and voiding volume of the subject. A report may be generated from the raw data and/or calculated values. In addition, one or more signals may be sent to the external device and/or a docking station, or communicated by other means, to indicate to the subject that the operation of the medical apparatus should be altered. 1. A medical apparatus comprising:an internal device implanted within a subject and including a driven magnet; and determine that the drive magnet of the external device is activated to magnetically rotate the driven magnet of the internal device, and', 'collect clinical data associated with the operation of the medical apparatus., 'an external device including a drive magnet, a processor, and a memory, the drive magnet of the external device magnetically coupled to the driven magnet of the internal device, wherein the memory is coupled to the processor and wherein the processor is configured to2. The medical apparatus of wherein the processor is further configured to perform one or more calculations on the collected clinical data.3. The medical apparatus of wherein the drive magnet is activated based on a button on the external device being pressed.4. The medical apparatus of wherein the collected clinical data is associated with a voiding behavior of the subject.5. The medical apparatus of wherein the collected clinical data includes at least a voiding frequency claim 4 , a voiding volume claim 4 , an estimated real-time flow rate claim 4 , and an estimated average flow ...

Catheter Assembly/Package Utilizing A Hydrating/Hydrogel Sleeve And A Foil Outer Layer And Method Of Making And Using The Same

A catheter assembly includes a catheter, a coating, a fluid containing sleeve, and a container. The catheter may include one or more distal drainage openings. The coating may be disposed on an outer surface of the catheter. The fluid containing sleeve may have an outer foil layer and be configured for positioning over the outer surface of the catheter to maintain the coating in a hydrated state. The container may enclose the catheter and the fluid containing sleeve. Substantially all fluid in the container may be disposed in the fluid containing sleeve. 1. A catheter assembly , comprising:a catheter including one or more distal drainage openings;a coating disposed on an outer surface of the catheter;a fluid containing sleeve having a foil outer layer, the fluid containing sleeve configured for positioning over the outer surface of the catheter to maintain the coating in a hydrated state; anda container enclosing the catheter and the fluid containing sleeve, wherein substantially all fluid in the container is in the fluid containing sleeve.2. The catheter assembly according to claim 1 , wherein the container includes a foil layer.3. The catheter assembly according to claim 2 , wherein the foil layer is the sole layer of the container.4. The catheter assembly according to claim 2 , wherein the container includes a plurality of layers claim 2 , the foil layer of the container being an inner layer in contact with the foil outer layer of the fluid containing sleeve.5. The catheter assembly according to claim 2 , wherein the foil outer layer of the container is secured to the foil outer layer of the fluid containing sleeve.6. The catheter assembly according to claim 2 , wherein the foil layer of the container is generally cylindrical.7. The catheter assembly according to claim 1 , wherein the fluid containing sleeve is structured and arranged to swell when exposed to a fluid.8. The catheter assembly according to claim 1 , wherein the fluid containing sleeve is structured ...

Organ for transplantation and organ structure

An organ for transplantation having a kidney, a ureter, and a urinary bladder and an organ structure in which a first ureter, a first urinary bladder, a second ureter and a second urinary bladder are sequentially connected to a kidney can produce urine and excrete the produced urine, and thus is useful for transplantation.

PIXEL ARRAY MEDICAL SYSTEMS, DEVICES AND METHODS

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject. 1. A method , comprising:identifying a donor site on a subject;removing a portion of the epidermis within the donor site;harvesting a plurality of dermal plugs within the donor site;forming an injectable filler by mincing the dermal plugs; andinjecting the injectable filler into a recipient site on the subject, wherein the recipient site is different from the donor site.2. The method of claim 1 , wherein the injectable filler comprises a live autologous dermal matrix (LADMIX) injectable filler.3. The method of claim 2 , wherein the injectable filler comprises live fibroblasts.4. The method of claim 1 , wherein the removing the portion of the epidermis comprises removing the portion of the epidermis in a region of the donor site.5. The method of claim 1 , wherein the removing the portion of the epidermis comprises removing the portion of the epidermis in a plurality of regions of the donor site.6. The method of claim 1 , wherein the removing the portion of the epidermis comprises delaminating the epidermis from the dermis in at least one region of the donor site.7. The method of claim 6 , wherein the delaminating comprises blistering skin.8. The method of claim 6 , wherein the delaminating comprises blistering skin at the donor site.9. The method of claim 6 , wherein the delaminating comprises vibratory shearing.10. The method of claim 9 , wherein the vibratory shearing comprises at least one of vacuum and heat.11. The method of claim 6 , wherein the delaminating comprises superficial injection.12. The method of claim 11 , wherein the superficial injection comprises at least one of saline and anesthetic.13. The method of claim 1 , ...

DEVICE TO PREVENT URINARY LEAKAGE

A device to prevent urinary leakage intended to be implanted in a patient includes a compressor to compress the patient's urethra, an electronic controller to actuate the compressor, and a measurer to measure the patient's activity. The measurer is coupled with the controller and the controller functions according to a predictive model of urinary leakage based on patient activity, so as to anticipate a possible urinary leak in relation to the measured activity of the patient. 1. A device to prevent urinary leakage intended to be implanted in a patient , comprising:compression means to compress the urethra of the patient,electronic control means to actuate the compression means, andmeasurement means to measure the activity of the patient and coupled with the control means, the control means operating in accordance with a predictive model of urinary leakage based on the activity of the patient, so as to anticipate any urinary leakage depending on the measured activity of the patient.2. The device of claim 1 , wherein the measurement means comprise means to measure the position and movement of the patient.3. The device of claim 2 , wherein the means to measure the position and movement of the patient comprise an accelerometer comprising one or more measurement axes.4. The device of claim 1 , wherein the measurement means comprise means to measure the intra-abdominal pressure of the patient.5. The device of claim 1 , wherein the measurement means comprise means to measure the intra-vesical pressure.6. The device of claim 1 , wherein the measurement means comprise means to measure the endo-urethral pressure of the patient.7. The device of claim 1 , wherein the measurement means comprise means to measure the activity of a muscle.8. The device of claim 7 , wherein the means to measure the activity of a muscle comprise a mechanomyograph sensor intended to be placed on said muscle to measure the movements generated by contractions of said muscle.9. The device of claim 7 , ...

Catheter Assembly/Package Utilizing A Hydrating/Hydrogel Sleeve And A Foil Outer Layer And Method Of Making And Using The Same

A catheter assembly package includes a hydrating sleeve and a catheter disposed in the hydrating sleeve, the hydrating sleeve and the catheter enclosed in a sealed package. A coating can be disposed on an outer surface of the catheter and in contact with an inner surface of the hydrating sleeve. The hydrating sleeve can include a fluid and an outer foil layer, and the fluid can be confined to the hydrating sleeve. The sealed package can enclose the hydrating sleeve in a first compartment and the catheter in a second compartment. 1. A catheter assembly package , comprising:a hydrating sleeve including a fluid and an outer foil layer;a catheter disposed in the hydrating sleeve, the catheter including a coating on an outer surface in contact with an inner surface of the hydrating sleeve; anda sealed package enclosing the hydrating sleeve and the catheter, the fluid confined to the hydrating sleeve.2. The catheter assembly package according to claim 1 , wherein the sealed package includes a foil layer.3. The catheter assembly package according to claim 2 , wherein the foil layer is a sole layer of the sealed package.4. The catheter assembly package according to claim 2 , wherein the sealed package includes a plurality of layers claim 2 , the foil layer of the sealed package being an inner layer in contact with the foil outer layer of the hydrating sleeve.5. The catheter assembly package according to claim 2 , wherein the foil layer of the sealed package is secured to the outer foil layer of the hydrating sleeve.6. The catheter assembly package according to claim 2 , wherein the foil layer of the sealed package is generally cylindrical.7. The catheter assembly package according to claim 1 , wherein the hydrating sleeve is structured and arranged to swell when exposed to the fluid.8. The catheter assembly package according to claim 1 , wherein the hydrating sleeve is structured and arranged to absorb about 90% of its weight in fluid.9. The catheter assembly package ...

BIOMIMETIC ARTIFICIAL BLADDER

Provided is an artificial bladder including: a main body which includes an inlet port, an outlet port, and a predetermined reservoir portion configured to store urine between the inlet port and the outlet port and is formed of a biocompatible polymer that is expandable so that a volume of the reservoir portion changes according to the amount of urine; a sensor which is attached to an outer wall of the main body, has a surface having a wrinkled structure, and is provided so that, when the volume of the reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes; and an actuator which is provided at the outlet port and is configured to discharge the urine according a result detected by the sensor. 1. An artificial bladder comprising:a main body which includes an inlet port, an outlet port, and a predetermined reservoir portion configured to store urine between the inlet port and the outlet port and is formed of a biocompatible polymer that is expandable so that a volume of the reservoir portion changes according to the amount of urine;a sensor which is attached to an outer wall of the main body, has a surface having a wrinkled structure, and is provided so that, when the volume of the reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes; andan actuator which is provided at the outlet port and is configured to discharge the urine according a result detected by the sensor.2. The artificial bladder of claim 1 , wherein the biocompatible polymer is formed of a hydrogel having a double-network structure.3. The artificial bladder of claim 1 , wherein the biocompatible polymer is formed by cross-linking a hydrogel and a nanofiber.4. The artificial bladder of claim 1 , wherein the sensor comprises a strain sensor configured to measure expansion and a shape change of the main body.5. The artificial bladder of claim 4 , wherein the strain sensor is provided so that resistance thereof ...

Implantable medical device

A method is taught for communicating information between a bladder disposed within an individual and the exterior of the individual. The method includes providing an implantable medical device having an operating component for performing operations within the bladder, a communication device for providing a communication regarding the operation between the implantable medical device and the exterior of the individual, and an energy source for applying energy to the implantable medical device. The method also includes inserting at least a portion of the implantable medical device into the bladder of the individual by way of the urinary tract of the individual. The step of performing the operation and communicating the information regarding the operation from within the bladder to the exterior of the individual by the implantable medical device is also set forth. The operating component can be a sensor for sensing a parameter of the bladder such as, for example, a pressure sensor for sensing the pressure within the bladder or a temperature sensor for sensing the temperature within the bladder. Furthermore, the operating component can be a valve such as a fluid valve adapted to prevent a flow of fluid from the bladder of the individual. The fluid valve can be operated in accordance with the sensor. The pressure level determination is communicated to the exterior of the body of the individual. A control signal is transmitted from the exterior of the body of the individual to the implantable medical device within the body of the individual in accordance with the communicated pressure level determination. The fluid valve is operated in accordance with the control signal from the exterior of the body.

Implantable device for external urinary control

The present invention relates to an implantable apparatus for obtaining urinary control and emptying of the urinary bladder, The apparatus operates with a powered member (100) operating from the outside of the urinary bladder assisted by a support structure to discharge urine from the urinary bladder. A control device (200) controls the operation of the powered member. The control device further comprises a source of energy for operating the powered member and other energy consuming parts of the apparatus and a control assembly.

Implantable urinary control apparatus

An implantable urinary control apparatus for controlling the flow of urine from the bladder including a pump adapted to be connected to the bladder for pumping urine out of the bladder and into a natural or artificial channel so that it can be from the fromthe body. The apparatus also includes a sensor adapted to be connected to the natural or to an artificial urinary bladder for detecting the pressure in the bladder as it fills with urine, and an alarm unit connected to the sensor for giving warning that the bladder is filling with urine when the sensor detects the pressure caused by urine in the bladder.

Orthotopic artificial bladder endoprosthesis

An orthotopic artificial bladder endoprosthesis comprises a casing (2) made of a PGA fiber fabric; said casing (2) having two first connectors (3) for the connection with the ureters of a patient and a further connector (4) for the connection with the urethra of a patient; an inflatable element (5) inserted in said casing (2); said inflatable element (5) being switchable between an inflated configuration, in which it supports and maintains in position the casing (2), and a deflated configuration.

orthotopic artificial bladder stent graft

uma endoprótese de bexiga artificial ortotópica compreende um invólucro (2) feito de um tecido de fibra de pga; o referido invólucro (2) tendo dois primeiros conectores (3) para a ligação com os ureteres de um paciente e um segundo conector (4) para a ligação com a uretra de um paciente; um elemento de suporte (5) sendo inserido no referido invólucro (2); o referido elemento de suporte (5) sendo comutável entre uma configuração estendida, na qual suporta e mantém em posição o invólucro (2), e uma configuração retraída. an orthotopic artificial bladder stent graft comprises a casing (2) made of a pga fiber fabric; said housing (2) having two first connectors (3) for connection with a patient's ureters and a second connector (4) for connection with a patient's urethra; a support element (5) being inserted into said housing (2); said support element (5) being switchable between an extended configuration in which it supports and holds the housing (2) in position and a retracted configuration.

Patent FR2347030B1

Prosthesis with bladder that adjusts girth

A prosthetic device comprises a column formed of resilient material and having a proximal end and a distal end. The prosthetic device comprises a bladder having a liquid cavity at the distal end. The bladder is inflatable and deflatable to increase and decrease a girth at the distal end of the prosthetic device. The prosthetic device comprises a liquid supply system that couples along the column to the bladder for selectively controlling liquid flow to the bladder to increase and decrease the girth.

Implantable device for internal urinary control

The present invention relates to an implantable apparatus for obtaining urinary control and emptying of the urinary bladder, thereby preventing from or treating involuntary urinary retention. In general terms, the apparatus comprises an expandable member adapted to be implanted inside the urinary bladder of the patient for discharging urine, and a control device for controlling the volume of the expandable member. The control device is adapted to be connected to the expandable member through the wall of the urinary bladder.

Pixel array medical systems, devices and methods

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Pixel array medical systems, devices and methods

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Catheter assembly/package utilizing a hydrating/hydrogel sleeve and a foil outer layer and method of making and using the same

A catheter assembly including an elongate member having a proximal end and a distal end. The distal end has at least one drainage opening. A hydrophilic coating is provided on at least a portion of the elongate end of the catheter. A fluid containing member is provided and is either arranged on the elongate member or within a separate area of the container. The fluid containing member contains sufficient hydrating fluid to hydrate the coating of the catheter. A container contains the elongate member and the fluid containing member and incorporates at least one foil layer to prevent evaporation of the hydrating fluid. A method of using the catheter includes inserting a catheter into a user's body and draining fluid from the user's body.

Catheter assembly/package utilizing a hydrating/hydrogel sleeve and a foil outer layer and method of making and using the same

A catheter assembly includes a catheter, a fluid containing sleeve, and a container. The catheter may include a tubular portion between a proximal end and a distal end, a coating on a length of the tubular portion, and at least one drainage opening on the distal end. The fluid containing sleeve is designed for arrangement on the tubular portion to maintain the coating in a hydrated state. The container may have at least one foil inner layer containing therein the catheter and the fluid containing sleeve. Substantially or nearly all fluid contained in the container may be disposed in the fluid containing sleeve.

Catheter assembly/package utilizing a hydrating/hydrogel sleeve and a foil outer layer and method of making and using the same

A catheter assembly package includes a hydrating sleeve and a catheter disposed in the hydrating sleeve, the hydrating sleeve and the catheter enclosed in a sealed package. A coating can be disposed on an outer surface of the catheter and in contact with an inner surface of the hydrating sleeve. The hydrating sleeve can include a fluid and an outer foil layer, and the fluid can be confined to the hydrating sleeve. The sealed package can enclose the hydrating sleeve in a first compartment and the catheter in a second compartment.

Catheter assembly/package utilizing a hydrating/hydrogel sleeve and a foil outer layer and method of making and using the same

A catheter assembly includes a catheter, a coating, a fluid containing sleeve, and a container. The catheter may include one or more distal drainage openings. The coating may be disposed on an outer surface of the catheter. The fluid containing sleeve may have an outer foil layer and be configured for positioning over the outer surface of the catheter to maintain the coating in a hydrated state. The container may enclose the catheter and the fluid containing sleeve. Substantially all fluid in the container may be disposed in the fluid containing sleeve.

Hemisphere for bladder expansion in patients with low compliance

FIELD: medicine. SUBSTANCE: invention relates to medicine and surgery. Implant is designed for increasing the volume of an atrophied bladder. It is made in the form of a hemisphere of biocompatible material: polylactic acid and silicone coated with pyrolytic turbostratic carbon or with amorphous diamond-like carbon. Coating of an implant provides growth of autologous cells of a fibrous capsule on it without contamination of cultivated cells. EFFECT: implant makes it possible to increase volume of a bladder due to cross-linking biologically compatible dome-shaped device with a bladder using welded resolve or non-resolve materials. 7 cl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61F 2/04 (13) 2 605 146 C2 (2013.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013145426/14, 02.03.2012 (24) Дата начала отсчета срока действия патента: 02.03.2012 (72) Автор(ы): САМБУССЕТИ Антонио (IT) (73) Патентообладатель(и): САМБУССЕТИ Антонио (IT) R U Приоритет(ы): (22) Дата подачи заявки: 02.03.2012 (30) Конвенционный приоритет: 11.03.2011 IT MI2011A000387 (43) Дата публикации заявки: 20.04.2015 Бюл. № 11 C 2 R U 2 6 0 5 1 4 6 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 11.10.2013 (86) Заявка PCT: EP 2012/053676 (02.03.2012) (87) Публикация заявки PCT: WO 2012/123272 (20.09.2012) Адрес для переписки: 105082, Москва, Спартаковский пер., д. 2, стр. 1, секция 1, этаж 3, "ЕВРОМАРКПАТ" (54) ПОЛУСФЕРА ДЛЯ РАСШИРЕНИЯ МОЧЕВОГО ПУЗЫРЯ У ПАЦИЕНТОВ С НИЗКИМ УРОВНЕМ РАСТЯЖИМОСТИ (57) Реферат: Изобретение относится к медицине, хирургии. турбостратного или аморфного алмазоподобного Имплантируемое устройство предназначено для углерода. Покрытие имплантируемого устройства расширения атрофированного мочевого пузыря. обеспечивает рост на нем аутологичных клеток Выполнено в виде полусферы из биологически из фиброзной капсулы без обсеменения совместимого материала: полимолочной кислоты культивируемыми клетками. ...

Stoma device using artificial bowel extension prothesis

The present invention relates to an artificial stoma comprising a bowel extension prosthesis made of an elastic biocompatible material and anastomosed with a resected end of the bowel; an outer case which surrounds and protects the bowel extension prosthesis; a balloon member formed between the bowel extension prosthesis and the outer case in a ring shape, and configured to be expanded by air injection thereby opening or closing the bowel extension prosthesis; and a nodule having one end penetrating the outer case and connected to the balloon member, and the other end connected to an external air injection device. According to the present invention, it is possible to achieve stable anastomosis of bowel and prevent the anastomosed portion from being tensioned since the bowel extension prosthesis is made of a biocompatible material, and the balloon member capable of opening and closing the bowel extension prosthesis allows the bowel extension prosthesis to serve as an artificial bowel, and a patient can control the bowel extension prosthesis by using the nodule, and the bowel is secured on the abdominal wall of the lower fascia portion and anastomosed with the bowel extension prosthesis thereby preventing the bowel from being exposed and achieving improved hygiene.

Method of producing fused biomaterials and tissue

It is a general object of the invention to provide a method of effecting tissue repair or replacement using a biomaterial. It is a specific object of the invention to provide a biomaterial suitable for use as a stent, for example, a vascular stent, or as a conduit replacement, as an artery, vein or a ureter replacement. The biomaterial can also be used as a stent or conduit covering or lining. The present invention relates to a method of repairing, replacing or supporting a section of a body tissue. The method comprises positioning a biomaterial at the site of the section and bonding the biomaterial to the site or to the tissue surrounding the site. The bonding is effected by contacting the biomaterial and the site, or tissue surrounding the site, at the point at which said bonding is to be effected, with an energy absorbing agent. The agent is then exposed to an amount of energy absorbable by the agent sufficient to bond the biomaterial to the site or to the tissue surrounding the site.