СИСТЕМА И СПОСОБ ЭНДОЛЮМИНАЛЬНОГО ПРОТЕЗИРОВАНИЯ РАЗВЕТВЛЯЮЩИХСЯ СОСУДОВ И СОСУДОВ С ОТВЕТВЛЕНИЯМИ

Группа изобретений относится к хирургии и может быть применима для эндолюминального протезирования основного анатомического канала в теле пациента в области, в которой по меньшей мере один ответвляющийся анатомический канал отходит от основного анатомического канала. Система включает эндоаортальный имплантат и имплантат ответвления. Эндоаортальный имплантат содержит первую гибкую трубку, имеющую по меньшей мере один проем ответвления, гибкое магнитное кольцо, размещенное вокруг по меньшей мере одного проема ответвления, устройство фиксации для поддержания первой трубки в практически фиксированном положении внутри основного анатомического канала так, чтобы проем ответвления совмещался с ответвляющимся анатомическим каналом. Имплантат ответвления содержит вторую гибкую трубку, соединительное устройство, выборочно приводимое в действие для соединения проксимального конца второй трубки с проемом ответвления первой трубки после приведения его в действие для обеспечения протекания текучей среды ...

ФИКСИРУЮЩЕ УСТРОЙСТВО

... 1. Фиксирующее устройство, связываемое с первым объектом для прикрепления указанного объекта ко второму объекту и содержащее, по меньшей мере, один фиксирующий элемент, имеющий базовую часть и, по меньшей мере, одну закрепляющую часть, при этом ! фиксирующий элемент первоначально формируется с закрепляющей частью, имеющей первую ориентацию относительно базовой части, и с возможностью придания закрепляющей части второй ориентации относительно базовой части для обеспечения возможности вхождения, по меньшей мере, одной закрепляющей части, при сохранении второй ориентации, во второй объект, открытый для такого вхождения, и способной изменять вторую ориентацию на первую ориентацию для осуществления указанного прикрепления. !2. Устройство по п.1, отличающееся тем, что, по меньшей мере, один фиксирующий элемент содержит удерживаемую часть, находящуюся между его базовой и закрепляющей частями, причем указанный фиксирующий элемент первоначально формируется с закрепляющей частью, имеющей первую ориентацию ...

ПРОТЕЗ ДЛЯ СОЕДИНЕНИЯ АНАТОМИЧЕСКОГО КАНАЛА

... 1. Трубчатый протез для соединения анатомического канала (С), который содержит, по меньшей мере, два отдельных трубчатых элемента (2) и механические средства (4) для соединения указанных отдельных элементов друг с другом,в котором механические соединительные средства являются герметичными (4) и содержат:- две имеющие кольцевую форму соединительные части (6), при этом каждая из них прикреплена к свободному концу (5L) отдельного трубчатого элемента (2);- по меньшей мере, одно уплотнение (8), имеющееся на одной из двух соединительных частей (6) и выполненное таким образом, чтобы вставляться между двумя соединительными частями (6) вокруг отверстия (3), образованного трубчатым протезом; и- первое и второе фиксирующее кольцо (9А, 9В), причем через каждое проходит отдельный трубчатый элемент (2) и каждое выполнено таким образом, чтобы взаимодействовать друг с другом для удерживания вместе, относительно одна другой, двух соединительных частей (6), между которыми сжимается уплотнение (8).2. Протез ...

СОСУДИСТЫЕ ТРАНСПЛАНТАТЫ И СПОСОБЫ ИХ ПРОВЕДЕНИЯ ЧЕРЕЗ УЧАСТКИ ОТВЕТВЛЕНИЯ БОКОВОЙ ВЕТВИ СОСУДА

... 1. Сосудистый трансплантат, приспособленный для размещения в основном кровеносном сосуде и приспособленный для прохождения через участок ответвления боковой ветви сосуда, содержащий трубчатое устройство, ограничивающее наружную поверхность, первую часть наружной поверхности, подобранную по размеру для вступления в контакт и для поддержки кровеносного сосуда с одной стороны боковой ветви, и вторую часть наружной поверхности, подобранную по размеру для вступления в контакт и для поддержки кровеносного сосуда с другой стороны боковой ветви, причем трубчатое устройство ограничивает отверстие для совмещения с боковой ветвью для обеспечения возможности потока крови между кровеносным сосудом и боковой ветвью, отличающийся тем, что каждая из первой и второй частей наружной поверхности выполнена трубчатой и содержит гибкий корпус трансплантата и поддерживающий стент, и в котором первая и вторая части разделены промежутком, и, кроме того, содержащий, по меньшей мере, один соединительный элемент, ...

VORRICHTUNG ZUR BEHANDLUNG VON BLUTGEFÄSSEN

ROHRFÖRMIGES, CHIRURGISCHES IMPLANTAT

VERBINDUNGSVORRICHTUNG ZWISCHEN EINEM KÖRPERKANAL UND EINER PROTHESE

Stent-Graft mit verbesserter Befestigung in einem Körpergefäss

BESCHICHTUNGEN FÜR MEDIZINISCHE VORRICHTUNGEN

BESCHICHTETE MEDIZINISCHE GERÄTE

VORRICHTUNG ZUM BEFESTIGEN EINES IMPLANTATS AN EINEM BLUTGEFÄSS

KLEINLUMIGES BIOLOGISCHES TRANSPLANTAT MIT THERAPEUTISCHER VERABREICHUNGSVORRICHTUNG

Apparatus for use in coronary artery bypass surgery

The apparatus comprises a blood flow conduit 10 of T- or L-shape having a first end for insertion into and retention within a wall of a heart chamber 44 containing oxygenated blood and a second end for retention within a coronary artery 30, the conduit defining an open flow blood path during both systole and diastole. The conduit may be such as to bias forward flow of blood from the first towards the second end while not blocking reverse flow and may comprise a deflection surface for blocking flow through the conduit from impinging directly upon the coronary artery. Means may be provided in the conduit for reducing but not blocking blood flow during diastole.

Blood pump apparatus

Blood pump apparatus comprising a pump housing 13, a drive chamber 18, a compressible blood chamber 20 and a drive mechanism including a pumping arm 33 and a movable plate 28. Bellows 38 hermetically seal an end of the drive chamber to prevent ingress of bodily fluids. The drive mechanism may include a motor (56) for rotating an eccentric shaft 47. In use, the motor rotates a cam such as roller bearing 52 causing the pumping arm 33 to pivot which cycles the movable plate 28 against chamber 20 to pump blood. The movable plate may be placed adjacent a lung such that the lung moves with plate 28, thus eliminating the need for a separate compliance chamber. The apparatus may be provided with other features such as a speed reducer (70) , a tissue. friendly enclosure (105) and a sensor 33 for determining the volume of blood in chamber 28.

Arteriovenous Access Valve System and Process

There is provided a subcutanous arteriovenous graft system. The system comprises an arteriovenous graft (12) having an arterial end (14) and an opposite venous end (16), and at least one valve device (60,80) positioned at the arterial end of the arteriovenous graft (12). The valve device (60,80) may comprise a piston (72) in fluid communication with a fluid chamber (62), wherein, when a fluid is forced into the fluid chamber (62), the piston (72) closes which, in turn, constricts the arteriovenous graft (12). The valve device (60,80) may comprise a magnetically activated piston (84), wherein, when a magnetic field is placed in close proximity to the valve device (80), the piston (84)is moved for either opening or closing the valve device (80).

Blood pump apparatus

Blood pump apparatus

In one aspect, the invention provides a blood pump apparatus comprising a pump housing 13, a drive chamber 18, a compressible blood chamber 20 and a drive mechanism including a pumping arm 33 and a movable plate 28. The drive mechanism can include a motor (56) for rotating an eccentric shaft 47. In use, the motor rotates a cam such as roller bearing 52 causing the pumping arm 33 to pivot which cycles the movable plate 28 against chamber 20 to pump blood. The movable plate may be placed adjacent a lung such that the lung moves with plate 28, thus eliminating the need for a separate compliance chamber. The apparatus may be provided with other features such as a speed reducer (70), hermetically sealing bellows (38) for the drive chamber, a tissue friendly enclosure (105) and a sensor 33 for determining the volume of blood in chamber 28.

Single chamber blood pump

Prosthetic grafts

Anastomotic coupling

A tubular vascular graft is attached to a rigid tubular portion of an implantable prosthetic device by assembling the vascular graft plus a surrounding heat-shrinkable polymeric sleeve on the rigid tubular portion. The polymeric sleeve, which may be TEFLON-FEP, extends a short distance past the free end of the tube and upon heating shrinks into firm compressive contact with the vascular graft and provides a smooth transition in stiffness between the end of the rigid tube and the soft, flexible graft.

MEANS OF MOUNTING FOR CONNECTING A TUBULAR BLOOD VESSEL PROSTHESIS

IMPROVED STENT FOR STENT GRAFT

STENT GRAFT WITH FOLDED FABRIC

TO DEVICE AND PROCEDURE FOR THE PRODUCTION OF A WITH A FLANGE OF EQUIPPED TRANSPLANT FOR ONE END TO SINCE ANASTOMOSIS

COATINGS F�R MEDICAL DEVICES

PROSTHESIS FOR THE REPAIR A THORAX ANEURYSM

CONTAINER FABRIC WITH GAUZE SAMPLES.

BISTABILE STRUCTURE OF FEATHER/SPRING FOR A STENT

SUPRANIERENPROTHESE AND KIDNEY ARTERIENBYPASS

MEDICAL TRANSPLANT LINK OR PLUG AS WELL AS PROCEDURE FOR YOUR PRODUCTION

ACTIVE SUBSTANCE DELIVERY SYSTEMS FOR THE TREATMENT OF CONTAINER ILLNESSES

DEVICE FOR BRINGING IN A MEDICAL TRANSPLANT

BILATERAL EXTENSION PROSTHESIS

STENT GRAFT WITH A SCHR�GABZWEIG

DEVICE FOR FASTENING AN IMPLANT TO A BLOOD VESSEL

IMPROVED STENT FOR STENT GRAFT

TRANSPLANT CATHETER F�R OF VASKULARES ENTRANCE SYSTEM

MEDICAL TRANSPLANT LINKS

A device for local drug delivery and methods for using the same

Graft-catheter vascular access system

An adjustable shape changeable surgical implant system

An adjustable shape changeable surgical implant system comprises a shape changeable surgical implant (1) having a swelling body (2) adapted to absorb and release fluid to swell and shrink, respectively, thereby changing the shape of said implant (1), a selective receptor (3) anchored inside the swelling body (2) and configured to selectively bind a corresponding selective ligand (4), a shape control substance (5) which can be administered to a patient carrying the shape changeable surgical implant (1), wherein the shape control substance (5) comprises the selective ligand (4) as well as a hydrophilic substance (6) connected to the ligand (4), such that in response to the selective receptor (3) binding the selective ligand (4), the swelling body absorbs liquid through hydrophilization, thereby changing the shape of the implant (1).

Delivery devices for treatment of vascular disease

Method and apparatus for performing an anastamosis

Anastomosis sheath and method of use

Barbed anchors for implantable medical device

A prosthesis for a blood vessel

PROSTHETIC TUBULAR GRAFT FOR ANEURYSMS

System and method for endoluminal grafting of bifurcated or branched vessels

Medical grafting methods and apparatus

Tubular body structure marking methods and apparatus

Artificial tubular body organ grafts

GRAFT-CATHETER VASCULAR ACCESS SYSTEM

A vascular access device, for implantation at least partially below the skin of a patient to provide an arteriovenous fistula, includes a graft portion coupled to a catheter portion. The graft portion is sutured to an opening in an artery while the catheter portion is inserted into a vein so that its end lies within the vein downstream from the point of entry into the vein. The device may be comprised of ePTFE with an outer polyurethane coating or the graft portion may comprise ePTFE with an outer polyurethane coating and the catheter portion may comprise polyurethane. There may also be an inner polyurethane coating. Alternatively, the device may be comprised entirely of polyurethane.

INTRA/EXTRA-THORACIC COLLATERAL VENTILATION BYPASS SYSTEM

A long term oxygen therapy system having an oxygen supply directly linked with a patient's lung or lungs may be utilized to more efficiently treat hypoxia caused by chronic obstructive pulmonary disease such as emphysema and chronic bronchitis. The system includes an oxygen source, one or more valves and fluid carrying conduits. The fluid carrying conduits link the oxygen source to diseased sites within the patient's lungs. A collateral ventilation bypass trap system directly linked with a patient's lung or lungs may be utilized to increase the expiratory flow from the diseased lung or lungs, thereby treating another aspect of chronic obstructive pulmonary disease. The system includes a trap, a filter/one-way valve and an air carrying conduit. In various embodiments, the system may be intrathoracic, extrathoracic or a combination thereof. In order for the system to be effective, an airtight seal between the parietal and visceral pleurae is required. Chemical pleurodesis is utilized for ...

HYBRID GRAFTS

The present application relates to unique surgical grafts. One embodiment of the present application relates to a surgical graft including a synthetic portion and an ECM portion connected thereto.

SUTURING MEANS FOR CONNECTING A TUBULAR VASCULAR PROSTHESIS TO A BLOOD VESSEL IN THE BODY IN ADDITION TO BRANCH MEANS, A VASCULAR PROSTHESIS, A DEVICE FOR INSERTING AND SUTURING AVASCULAR PROSTHESIS IN THE BODY, AND A VASCULAR PROSTHESIS SYSTEM

Suturing means and branch means, a vascular prosthesis, a device and a vascular prosthesis system. Suturing means for connecting a vascular prosthesis (40) to a blood vessel (50) comprise an internal, substantially annular body (10) intended to be received in the blood vessel (50) in addition to an external annular body (20) intended to lie clampingly on an outer wall of the blood vessel (50) at least practically at the location of the internal annular body (10). At least one of the two annular bodies (10, 20) is provided with suturing members (12) which grip in the vessel wall so as to effect an adequate fixation of at least the internal annular body (10). The invention also provides a device for use with such suturing means and further relates to a vascular prosthesis which is provided on at least one of its outer ends with at least a part of such suturing means. Different embodiments of such prostheses together form a modular vascular prosthesis system. A side vessel of thus supported ...

STENT

An elongate device (19), arcuate in cross-section, for placement around a vessel (4), comprises an essentially non-porous outer layer and a biodegradable inner layer. An alternative device comprises a tubular portion (3) for placement around a graft and a portion (2), arcuate in cross-section that can straddle a native vessel, at the site of an end- to-side anastomosis.

CATHETER BALLOON SYSTEMS AND METHODS

Apparatus and method are provided for treatment of a bifurcation of a body lumen. The apparatus includes an elongated catheter body having a proximal end and a distal end. A balloon is associated with the distal end of the balloon catheter. The balloon includes a main vessel balloon for treating a main vessel of the bifurcation, and a branch vessel balloon for treating a branch vessel of the bifurcation. The branch vessel balloon includes an accordion configuration capable of being expanded from an unexpanded collapsed accordion configuration to an expanded accordion configuration extending into the branch vessel.

EXTENDIBLE STENT APPARATUS

The bifurcating double stent apparatus (10) of the present invention comprises a generally cylindrical main stent (12), a generally cylindrical branch stent (15), which are shown as fully dilated in a subject main vessel (8), and a subject branch vessel (7). The main stent (12) is deployed prior to the branch stent (15) which is then aligned with the side opening (16) of the main stent (12), and attached at that location.

A STENT GRAFT HAVING IMPROVED ATTACHMENT WITHIN A BODY VESSEL

In accordance with the present invention there is provided an improved stent graft for insertion into a body vessel of a patient. The stent graft includes a hollow substantially cylindrical stent comprising a plurality of interconnected struts. In addition, the stent graft includes a graft material attached to the stent, wherein the graft material is an open cell foam material having a multiplicity of cells having an average diameter ranging from about 100-500 micrometers, and a cell density on a surface thereof ranging from about 50-100 cells per inch.

DEVICE FOR RAPID REPAIR OF BODY CONDUITS

A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion ...

INTRALUMINAL PROSTHESIS ATTACHMENT AND SYSTEMS

Systems and method implant prostheses in the body. The systems and method provide permanent attachment of the prosthesis in the body. The prosthesis can comprise, e.g., an endovascular graft, which can be deployed without damaging the native blood vessel in either an arterial or a venous system. The endovascular graft can comprise, e.g., a radially expanding vascular stent and/or a stent-graft. The graft can be placed in the vasculature, eg., to exclude or bridge an aneurysm, for example, an abdominal aortic aneurysms. The graft desirably adapts to change in aneurysm morphology and repairs the endovascular aneurysm. The fastening systems (27) and methods can be deployed through the vasculature and manipulated from outside the body, to deliver a fastener (28) to attach the graft to the vessel wall.

ENDOVASCULAR ANEURYSM REPAIR SYSTEM

Method and apparatus for implanting radially expandable prostheses (14) in the body lumens rely on tacking or anchoring of the prostheses with separately introduced fasteners (28). The prostheses may be self-expanding or balloon expandable. After initial placement, a fastener applier system (27) is introduced within the expanded prostheses to deploy a plurality of fasteners at at least one prosthesis end, usually as each end of the prosthesis. The fasteners are usually helical fasteners which are delivered from a helical track in the fastener applier by rotation with a rotator wire. The fasteners will be applied singly, typically in circumferentially spaced-apart patterns about the interior of each end of the prosthesis.

METHOD AND SYSTEM FOR BYPASSING AN ARTERY BLOCK

A catheter system for use in bypassing a blocking (3) in an artery (1) comprises four components. These components are an arterial catheter, an intravenous ultrasound catheter, a guide-wire system, and finally a covered stent (4) used as graft. The bypassing of the blocking (3) in the artery (1) which extends along a vein (2) comprises the steps of forming a first connection (6) between said artery (1) and said vein (2) proximal to the blocking (3) in the artery (1), forming a second connection (7) between said artery (1) and said vein (2) distal to the blocking (3) in the artery (1), introducing a covered stent (4) through said artery (1) proximal to the blocking (3) therein, through said first connection (6) into said vein (2), via said vein (2) to and through said second connection (7), and into said artery (1) distal to the blocking (3) therein, such that a proximal end (9) of the covered stent (4) is positioned in the artery (1) proximal to the blocking (3) therein and a distal end ...

A STENT GRAFT HAVING IMPROVED ATTACHMENT WITHIN A BODY VESSEL

In accordance with the present invention there is provided an improved stent graft for insertion into a body vessel of a patient. The stent graft includes a hollow substantially cylindrical stent comprising a plurality of interconnected struts. In addition, the stent graft includes a graft material attached to the stent, wherein the graft material is an open cell foam material having a multiplicity of cells having an average diameter ranging from about 100-500 micrometers, and a cell density on a surface thereof ranging from about 50-100 cells per inch.

COATINGS FOR MEDICAL DEVICES

The present invention includes biocompatible coatings and films for use on implantable medical devices and medical devices containing such coatings and films applied to a surface thereof, which coatings/films are present on the device in an amount effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of the device in the mammal, and contain a film-forming polyfluoro copolymer prepared from an amount of a monomer selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and an amount of a second monomer other than the first monomer, wherein the amounts of the first and second monomers are effective to provide the coating and films with properties effective for use in coating implantable medical devices when the coated device is subjected to a maximum temperature of less than about 100.degree.C.

DRUG RELEASING ANASTOMOSIS DEVICES AND METHODS FOR TREATING ANASTOMOTIC SITES

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

DEVICE AND METHOD FOR ATRAUMATIC AND PERCUTANEOUS FORMATION OF AN ARTERIOVENOUS FISTULA

Provided herein are novel devices for the formation of arteriovenous fistulas, which may aid subjects in need of hemodialysis. The novel devices are provided in a non-surgical procedure, greatly decreasing the cost and increasing the convenience of placing an arteriovenous fistula. The devices are atraumatic, and consist of a sutureless anastomosis device and conduit. Methods and tools for placing the devices in vivo are disclosed, including a magnetic-assisted method.

DOUBLE LAYER INTRALUMINAL GRAFT

Supplemental intraluminal graft extension achieved by cuff-means substantially fortify and enhance endovascularly emplaced systems, particularly for bridging aneurysms. Multiple embodiments based upon overlapping of at least two segments are taught. Cuff-means likewise have applications to restore patency to, or substantially enhance, prior failing emplacements of both home-made and other commercial devices.

DEVICES AND METHODS FOR FORMING MAGNETIC ANASTOMOSES AND PORTS IN VESSELS

Methods and devices for forming magnetic anastomoses between hollow bodies. End-to-side, side-to-side and end-to-end anastomoses can be created with or without a mechanical connection between the components. The anastomotic components (542) may have various constructions and may be secured to a vessel in various manners, for example, magnetically, mechanically or adhesively. Also provided are alternative delivery devices (550), as well as devices (770, 730) for checking the position of a component on a loaded delivery device (772), and for checking the seal between a vessel and an anastomotic component (774, 776) secured thereto.

ENDOVASCULAR ANEURYSM REPAIR SYSTEM

Method and apparatus for implanting radially expandable prostheses (14) in the body lumens rely on tacking or anchoring of the prostheses with separately introduced fasteners (28). The prostheses may be self-expanding or balloon expandable. After initial placement, a fastener applier system (27) is introduced within the expanded prostheses to deploy a plurality of fasteners at at least one prosthesis end, usually as each end of the prosthesis. The fasteners are usually helical fasteners which are delivered from a helical track in the fastener applier by rotation with a rotator wire. The fasteners will be applied singly, typically in circumferentially spaced-apart patterns about the interior of each end of the prosthesis.

CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL

Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.

SYSTEM AND METHOD FOR ENDOLUMINAL GRAFTING OF BIFURCATED OR BRANCHED VESSELS

The present invention is a system, and method for endoluminal grafting of a main anatomical conduit (e.g., the aorta), various branch conduits (e.g., si de branch vessels such as the carotid, innominate, subclavian, intercostal, superior mesenteric, celiac, or renal arteries or furcation such as the iliac arteries) which emanate from the main anatomical conduit. The grafting system generally comprises a primary graft having at least one opening therein, at least one branch graft which is passable through the opening of the primary graft, and into the branch conduit(s) suc h that the proximal end of each branch graft is in substantially fluid tight sealing contact with the primary graft. Also disclosed is a specific system, a method for graftin g a bifurcated anatomical conduit (e.g., the aorta ilea bifurcation) through onl y a single access opening (puncture site or incision), and a new balloon anchoring guid e wire system.

Einpflanzbare Verbindung

ORTHOTOPIC PROSTHESIS OF ARTIFICIAL BLADDER

UNIVERSAL ENDOVASCULAR GRAFTS

Universal eudovascular grafts are provided for evaluation and repair of damaged or aneurismal blood vessels. More particularly, the present invention relates to universal fenestrated and universal branched endografts for repair of blood vessels with branches, methods for implanting the endografts in the vessel and for making connection with one or more branches. The universal fenestrated endografts have a body with a first end, a second end, a first wall, a second wall, and an interior passage or lumen. The body further includes openings in communication with the passage at the first and second ends and one or more lateral fenestrations in communication with the lumen. The body further has a necked portion between the ends and a cannulation member. The universal branched endografts have a tubular body with a main lumen and four branch lumens. A large branch extends from the body. The four lumens are positioned about a circumference of the tubular body.

A SYNTHETIC VASCULAR GRAFT.

PROSTHESIS FLANGE

MEDICAL TO TOGETHER FIX THROUGH AN ANATOMICAL CONDUIT A LINING AND UNIMPLANT

Aortic prosthesis for extracorporeal circulation of blood has tube with branching perfusion duct of smaller section, fitted with quick-fit coupling

La présente invention a pour objet une prothèse aortique avec dispositif rapide de connexion a la circulation extra-corporelle. Elle est constituée d'un tube prothétique (1) équipé d'un conduit de perfusion (2) implanté latéralement et pourvu à son extrémité d'un connecteur rapide (4) destiné à être raccordé à la tubulure artérielle d'un système de circulation extra-corporelle. Elle se rapporte d'une manière générale au domaine de la chirurgie artérielle et plus particulièrement aux interventions visant au remplacement par une prothèse d'une partie ou de la totalité de l'aorte.

STENT FOR CONNECTING ADJACENT TISSUES OF HUMAN ORGANS ALLOWING AUTOMATIC INTERVAL ADJUSTMENT BY A WING UNIT

PURPOSE: A stent for connecting adjacent tissues of human organs is provided to allow the installation the stent regardless of the gap or thickness of adjacent tissues. CONSTITUTION: A stent for connecting adjacent tissues of human organs comprises a hollow cylindrical body(10) which is formed with multiple rhomboid spaces by weaving shape memory alloy wires to cross each other, and a wing unit(15) which is bent around a bent unit(11) and is extended and contracted in the longitudinal direction. The wing unit adheres closely to the adjacent tissue of the human organs. COPYRIGHT KIPO 2013 ...

Improved endoprosthesis anchoring and sealing

Described are various embodiments of an improved endoprosthesis that includes a generally cylindrical graft portion that extends along a longitudinal axis to define a flow passage and a plurality of stent hoops. The plurality of stent hoops are connected to the graft portion and disposed in a spaced apart relationship along the longitudinal axis. There is at least a first suture disposed along on the outer surface of the main body. The first suture connects at least two of the spaced apart stent hoops together. The first suture also includes unidirectional barbs (or multidirectional barbs) configured to reduce movement of the main body with respect to a direction of blood flow in an artery.

DEVICES AND METHODS FOR CREATING AND CLOSING CONTROLLED OPENINGS IN TISSUE

Devices and methods for creating and closing controlled, shaped openings in tissue, such as blood vessel walls or fascia layers, utilize an implantable access and closure device, or access port, with an aperture that demarcates a desired location for the opening in the tissue. Incision means for creating an opening through the tissue may include a crescent or arc-shaped heating element; a cutting wire; a water jet; or a cutting edge that is integrated into the access port. A self-sealing incision is also described. Closure means to seal the arteriotomy or other opening and provide hemostasis may include a net, patch, ring or wire that is deployed externally to the vessel, covering the arteriotomy site. Another closure means comprises a stent, or tube-like closure mechanism that is inserted through the arteriotomy site and deployed within the vessel. A side opening allows a procedure sheath to enter the blood vessel. After the procedure, the closure mechanism is rotated within the vessel ...

TREATMENT KIT, TREATMENT DEVICE, AND ASSOCIATED METHOD OF PRODUCTION

This kit has a first implant (16) defining a window (26), and a second implant (18) with a second tubular body (42) intended to be placed in the window (26). The second implant (18) has a member for retention of the second implant (18) with respect to the first implant. The kit comprises a ring (20) which retains the second implant (18), placed on the first tubular body (22), in the window (26) and delimits an insertion passage (60) for the second implant (18). The retention ring (20) is elastically deformable in the window (26) in order to permit a reversible increase of at least 20%, advantageously of at least 30%, in the external contour of the insertion passage (60).

SELF-EXPANDING ANASTOMOSIS DEVICE

A size-variable Implantable device comprises a body (1 10) comprising at least one attaching portion (120) configured for securing the device to a surgical site of a patient; a size-controlling member (130) configured for controlling at least one dimension of the device; and an actuator (140) arranged to actuate the size-controlling member. The device may comprise a mounting portion (160) for mounting one or more expandable conduits. The at least one attaching portion may be made from a deformable, e.g. an expandable and/or contractible, material, which may allow expansion and/or contraction of the size- variable implantable device. The device may comprise one or more sensors (170) for detecting, measuring, collecting, storing, and/or communicating data in the region of deployment of the device, which may cause the actuator to actuate the size-controlling device when one or more of the detected parameters reach a predetermined value.

IMPROVED SURGICAL IMPLANT DEVICES AND METHODS FOR THEIR MANUFACTURE AND USE

Sealable and repositionable implant devices are provided with one or more improvements that increase the ability of implants such as endovascular grafts to be precisely deployed or re¬ deployed, with better in situ accommodation to the local anatomy of the targeted recipient anatomic site, and/or with the ability for post-deployment adjustment to accommodate anatomic changes that might compromise the efficacy of the implant. A surgical implant includes an implant body and a selectively adjustable assembly attached to the implant body, having adjustable elements, and operable to cause a configuration change in a portion of the implant body and, thereby, permit implantation of the implant body within an anatomic orifice to effect a seal therein under normal physiological conditions.

GRAFT DEVICES AND METHODS OF FABRICATION

A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft device between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.

BIFURCATED STENT AND DELIVERY SYSTEM

Systems for delivering a bifurcated stent to a bifurcation site comprise catheters and/or bifurcated stents delivered therefrom.

METHOD AND APPARATUS FOR EFFECTING AN AORTIC VALVE BYPASS, INCLUDING THE PROVISION AND USE OF A T-STENT FOR EFFECTING A DISTAL ANASTOMOSIS FOR THE SAME

A connector for joining a first hollow structure to the side wall of a second hollow structure, the connector comprising a fluid-constraining tube having a fluid-constraining neck extending therefrom, wherein the tube comprises a lumen having a first opening and a second opening and the neck comprises a lumen having a first opening and a second opening, the neck being joined to the tube so that the neck is in fluid communication with the tube intermediate the length of the tube, such that fluid enteπng the first opening of the tube can exit the second opening of the tube, and fluid entenng the first opening of the neck can exit the second opening of the tube at least the portions of the tube adjacent to the first opening of the tube and the second opening of the tube being biased radially outwardly so that they normally assume a radially-expanded configuration.

ANASTOMOSIS CONNECTING APPARATUS

For connecting the end of a supplemental vessel to the side of a body vessel, which has a greater diameter than the supplemental vessel, use is made of a sleeve whose one end portion is expandable for the forming of an annular end flange. As a result, the supplemental vessel, after being passed through the sleeve in the direction of the expandable end portion and folding back at least over the expandable end portion, is formable into a collar, both sides of which enclose the annular end flange inside the supplemental vessel and internally surround an opening formed therein. The distal portion of the sleeve to be inserted into the body vessel may comprise a memory material enabling the end flange to be formed without using the balloon.

TRANSMYOCARDIAL IMPLANT

La présente invention concerne un implant transmyocardiaque qui permet d'établir un passage pour le flux sanguin au travers d'un myocarde, entre une cavité cardiaque et un vaisseau coronaire situé à l'extérieur du coeur. L'implant (10) comprend, d'une part un segment coronaire (12) calibré pour être reçu à l'intérieur du vaisseau, et d'autre part un segment myocardiaque (14) calibré pour traverser le myocarde et pénétrer dans la cavité cardiaque. Une zone de transition (13) relie le segment coronaire (12) au segment myocardiaque (14) de façon à faire passer le sang du segment myocardiaque (14) au segment coronaire (12). Le segment coronaire (12) et le segment myocardiaque (14) possèdent une construction ouverte de façon à permettre une croissance tissulaire dans l'épaisseur de paroi du segment coronaire (12) et du segment myocardiaque (14). Le segment myocardiaque (14) inclut un agent contrecarrant la coagulation en cascade et la formation de plaquettes.

VASCULAR GRAFTS AND METHODS FOR BRIDGING A VESSEL SIDE BRANCH

A vascular graft (20) for a primary vessel (22) adapted to bridge a side branch (24). The graft is especially useful for providing a support tube for a primary graft in the primary vessel on one side of the side branch. The graft includes first and second tubular sections separated by a gap. A bridging member (54) connects the first (50) and second tubular sections (52) across the gap and may include a relatively rigid strut to prohibit relative axial movement of the two sections. There may be one, two or more bridging members to define one, two or more apertures through which blood can flow from within the graft through to the vessel side branch. The graft may include a flexible, desirably fabric, body supported by a wireform stent that is either self- or balloon-expandable. The graft may be deployed within the abdominal aorta on both sides of the renal arteries and have two apertures for blood to flow from the aorta to the renals. The infra-renal section provides a uniform uniform tubular ...

TREATMENT OF RENAL FAILURE

This invention is an implantable ultrafiltration device for removing low to medium molecular weight solutes and fluids from the blood of a patient experiencing renal failure, the device including a pump (10) having an inlet and an outlet; a first component for forming a first fluid flow path (8) between the patient's vascular system and the pump inlet; a filter (6) interposed in the first fluid flow path, the filter being permeable to water and substantially impermeable to blood cells and proteins; and a second component (14) for forming a second fluid flow path between the pump outlet and the patient's bladder (16), wherein the pump, the first and second components, and the filter are all constructed to be surgically implanted in the patient's body. For removing unwanted fluids from the blood of a patient experiencing renal failure the first component is connected to the vascular system of the patient, and the second component is implanted in the patient's bladder or ureter (18); and the ...

Modular aneurysm repair system

The present invention is directed to a system, apparatus, and method for treating and/or repairing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a first prosthesis or first prosthesis, and at least one second prosthesis for bypassing the aneurysm, and at least one third prosthesis for establishing a fluid flow channel from the abdominal aorta into another artery, such as a renal artery.

Catheter-based fastener implantation apparatus and methods

Apparatus and methods utilize an intraluminal fastener applier having a guide body with a longitudinal axis. The guide body is sized and configured for intraluminal deployment in a hollow body organ. An actuated assembly is carried by the guide body that is selectively operable to generate an implantation force to implant at least one fastener into tissue within the hollow body organ. The actuated assembly includes a driven member extending generally along the longitudinal axis, which is sized and configured to engage a selected fastener. The actuated assembly also includes a drive member coupled to the driven member to impart the implantation force to the driven element in a direction that is at an angle to the longitudinal axis of the guide body.

Anastomosis systems

An end-side anastomosis system including a fitting comprising: a base for attachment to a graft, said base be configured to form a seal with an opening in a host vessel wall; a leading petal having a cross-section with a radius of curvature approximating a radius of curvature of the host vessel, said leading petal being configured to dilate the host vessel wall opening while advancing said fitting through the opening; and a rear petal, said rear petal being deflectable to be advanced through the host vessel opening.

SYSTEMS FOR ANCHORING A MEDICAL DEVICE IN A BODY LUMEN

A system for securing a device in tissue, having a sheath having a plurality of side openings; a rotatable element disposed within the sheath; and a plurality of curved projections extending from the rotatable element, wherein rotation of the rotatable element within the sheath pushes distal ends of each of the curved projections outwardly through one of the plurality of openings and into the tissue.

Synthetic vascular prosthesis

The present invention provides a synthetic vascular prosthesis which is formed by a first tube member and a second tube member. Both tube members have inner flow paths for blood. An end of the second tube member is connected with an outer surface of the first tube member, and the inner flow path of the second tube member is communicated with the inner flow path of the first tube member.

Access port system for anastomosis

An access port system of the present invention provides a passageway through which instruments are inserted into a target vessel during performance of an anastomosis procedure. The access port system is secured to an exterior surface of the target vessel and assists in axial alignment, depth registration, and sealing when inserting instruments into the target vessel. The access port system provides the capability of placing punching instruments, anastomosis instruments, and other instruments in their correct positions relative to a target vessel and providing hemostasis while inserting instruments into and removing instruments from the target vessel.

Reducing stress at vascular graft anastomoses

Methods for attaching prostheses to natural vessels are disclosed. Prosthetic vessels having improved resistance to occlusion by tissue reaction upon implantation by reducing transmural stresses are also disclosed. Prostheses having elliptical cross-sections governed by the maximum strain expected in the natural vessel and possessing a higher bulk compliance than previous designs are provided. Additionally, novel methods are presented for implanting improved prostheses by using angled bias cuts to produce an elliptical cross-section at each end of the natural vessel section receiving the prosthesis. In accordance with preferred embodiments, vessels are provided where the cross-sectional geometry is approximated by the equations: a=r0[1+2 epsilon (2+ epsilon )]1/2 and b=r0.

Method for percutaneous coronary artery bypass

A percutaneous system for bypassing a restriction in an artery of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. First and second expandable stents are provided at the first and second ends of the graft, respectively. Apertures are formed in the artery, distal of the restriction, and in the aorta and the graft is inserted between the apertures. At least a portion of the first stent is inserted through the aperture in the artery and the stent is deployed to connect the first end of the graft within the artery. The second stent is positioned such that a first expandable portion is outside the aorta and a second expandable portion is within the aorta. The first and second expandable portions of the second stent are expanded to have outer diameters at least as large as the aperture in the aorta to anchor the first end of the graft in the aorta such that the lumen in the graft communicates with the aorta and ...

Endovascular aneurysm repair system

Method and apparatus for implanting radially expandable prostheses in the body lumens rely on tacking or anchoring of the prostheses with separately introduced fasteners. The prostheses may be self-expanding or balloon expandable. After initial placement, a fastener applier system is introduced within the expanded prostheses to deploy a plurality of fasteners at least one prosthesis end, usually as each end of the prosthesis. The fasteners are usually helical fasteners which are delivered from a helical track in the fastener applier by rotation with a rotator wire. The fasteners will be applied singly, typically in circumferentially spaced-apart patterns about the interior of each end of the prosthesis.

Applicators for patches and adhesives

Apparatus is provided for use with a tubular structure ( 2 ) in a body of a patient. The apparatus includes an adhesive including first and second components, a container ( 27 ), one or more patches ( 3 ), and an applicator ( 1 ). The container ( 27 ) contains the first component of the adhesive and not the second component of the adhesive. The one or more patches ( 3 ) include the second component of the adhesive and not the first component of the adhesive. The applicator ( 1 ) is configured to removably hold the one or more patches ( 3 ), and to place the one or more patches ( 3 ) at least partially around the tubular structure ( 2 ). Other embodiments are also described.

Stent Graft System

The stent graft system in accordance with the present invention has a trunk, a left subclavian tube, a left common carotid tube and a brachiocephalic tube. The trunk is tubular and expandable and has a descending end, an ascending end, a left subclavian mount, a left common carotid mount and a brachiocephalic mount, for receiving the aforementioned branch tubes that are elastic and self-expandable for respectively connecting the left subclavian artery, the left common carotid artery and the brachiocephalic artery to the trunk. With the above-described structure, the present invention allows fast determination of a suitable trunk and branch tubes for a patient and allows a medical institute to prepare compatible branch tubes and trunks for a composite stent graft system instead of numerous stent grafts of various combinations of differently sized tubular bodies and branches, wherein the former requires significantly less warehousing cost than the latter.

Graft Devices and Methods of Use

A tubular graft device is provided comprising a tubular member and a fiber matrix of one or more polymers about a circumference of the tubular member. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft and connecting the graft between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.

Stent for connecting adjacent tissues of organs

Disclosed herein is a stent for connecting adjacent tissues of the organs of a patient. The stent includes a hollow cylindrical body which is formed by weaving a superelastic shape-memory alloy wire in an overlapping manner such that rhombic openings are formed, and wing parts which are provided by expanding respective opposite ends of the hollow cylindrical body outwards and turning the opposite ends inside out on bent portions. The wing parts face each other so that the wing parts are tensed in a longitudinal direction of the cylindrical body. Thereby, the wing parts can elastically move inwards or outwards with respect to the longitudinal direction to automatically adjust a distance between the wing parts in response to the distance between the adjacent tissues of the organs or thicknesses of walls of the organs, so that the wing parts are put into close contact with the adjacent tissues.

Branch vessel prostheses

The present embodiments provide a branch vessel prosthesis for placement at least partially between a main vessel and a branch vessel of a patient. The branch vessel prosthesis has a graft including a generally tubular body of a biocompatible material. At least one stent is coupled to a proximal region of the graft, and at least one stent is coupled to a distal region of the graft. The proximal region of the graft includes a generally straight configuration in an expanded deployed state that is substantially parallel to a longitudinal axis of a main vessel. The distal region of the graft includes a generally straight configuration in the expanded deployed state that is substantially parallel to a branch vessel. A curvature of a central region varies an angle in which the distal region of the graft is disposed relative to the proximal region.

Vascular Clamps for Vascular Repair

A magnetic vascular clamp for vascular repair is described. There is a vascular sleeve forming a flexible cylindrical bellows that cylindrically encloses a section of vascular tissue to allow freely movement of the enclosed vascular tissue within the vascular sleeve. A pair of sleeve anchor rings are at each end of the vascular sleeve and they form a fixed seal with underlying vascular tissue to minimize fluid leakage from within the vascular clamp.

BARBED ANCHORS FOR WIRE STENT

An endoluminal prosthesis that includes a support structure comprising a curvilinear portion having a first strut and a second strut that meet at an apex. Disposed on the support structure is an anchor with an anchor body and one or more barbs extending outwardly from the anchor body and where the anchor body comprises a multi-filar tube fits at least partially about, and conforms to the first strut, second strut, and the apex. 1. An anchoring device for an endoluminal prosthesis comprising:a plurality of independent wires arranged to form a multi-filar tube having a first tube section, a second tube section, a third tube section between the first and second tube sections, a first end and a second end,where each wire of the plurality of wires has a first end and a second end,where at least one end of a first wire forms a first barb that extends outwardly from a tube section of the anchoring device.2. The device of claim 1 , where the tube sections comprise at least one coil of the plurality of wires.3. The device of claim 1 , where a second wire has an end that forms a second barb that extends outwardly from a tube section of the anchoring device.4. The device of claim 3 , where the first wire end extends from the first tube section claim 3 , and the second wire extends from the second tube section.5. The device of claim 1 , further comprising a stent having a first strut claim 1 , a second strut and an apex between the first and second struts.6. The device of claim 5 , where the tube sections comprise a coil of the plurality of wires claim 5 , and the first tube section is wound about the first strut claim 5 , the second tube section is wound about the second strut claim 5 , and the third tube section is wound about the apex.7. The device of claim 1 , where the first barb is disposed at or near the first end of the multi-filar tube.8. The device of claim 7 , where at least one end of a second wire forms a second barb that extends outwardly from a tube section of ...

Assembly comprising a ring for attachment in a passage surrounded by body tissue as well as an applicator for fitting the ring in the passage

The present invention relates to an assembly comprising: a ring having anchoring elements for attaching the ring in a passage surrounded by body tissue, in particular blood vessel tissue. an applicator for fitting the ring in the passage; in which the anchoring elements have an anchoring position in which they protrude with respect to the ring, and in which the anchoring elements comprise a memory material, such as a memory metal or memory polymer, and are designed so that they can be bent from an anchoring position counter to a spring force into a fitting position and can be frozen in this fitting position by a temperature treatment in order to bend the anchoring elements back from the fitting position by the effect of this spring force into the anchoring position when a predetermined threshold temperature is exceeded, and in which the applicator is provided distally with a carrier for carrying the ring. The assembly according to the invention is provided with an influencing system for influencing the temperature of the anchoring elements of the ring carried by the carrier in such a way that the anchoring elements bend back from the fitting position to the anchoring position by increasing the temperature of the anchoring elements to above the threshold temperature.

Conduit Device and System for Implanting a Conduit Device in a Tissue Wall

Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device. 1. A system for securing in a ventricular wall of a heart and accessing a ventricle of the heart , the system comprising:an attaching device configured for attaching to the ventricular wall; anda cutting device configured for advancing through the attaching device and through the tissue wall to define an aperture extending from a first surface of the ventricular wall to a second surface of the ventricular wall;wherein the attaching device is configured to provide counter-traction for advancing the cutting device through the ventricular wall.2. The system of claim 1 , further comprising an inner tube configured for extending at least partially through the aperture to establish fluid communication between the first surface and the second surface of the ventricular wall claim 1 , wherein the attaching device is configured to prevent peri-sheath bleeding around the inner tube.3. The system of claim 1 , further comprising a sealing member configured for sealing against the epicardial surface of the ventricular wall.4. The system of claim 1 , further comprising a cap configured for closing the aperture and blocking fluid communication between the first surface and the second surface of the ventricular wall.5. The system of claim 1 , wherein the attaching device comprises a ...

Medical device delivery system and deployment method

An aortic stent-graft may include a tubular graft extending from a proximal end to a distal end, the graft comprising a proximal sealing portion and an intermediate portion, wherein a proximal end of the intermediate portion abuts the distal end of the proximal sealing portion. At least one sealing stent may be attached to the proximal sealing portion. A first fenestration window is disposed in the intermediate portion. The first fenestration window has a length determined by the equation L=1.23*D−24 millimeters, where L is the length of the first fenestration window. D is between about 24 millimeters and 45 millimeters.

Proteomic Antisense Molecular Shield and Targeting

The present invention provides compositions and methods for shielding and directing agents to biological targets in cellular systems for therapeutic, prophylactic, and diagnostic uses. Vascular devices are also provided which have coated surfaces that contain proteomic antisense, as well as therapeutic and other biological agents attached thereto.

Dialysis Graft with Thromboses Prevention Arrangement

A dialysis graft includes an artery connection section having one end connected to an artery; and a vein connection section having both ends connected to two sections of a vein respectively. Diameter of either end of the vein connection section is equal to that of the corresponding section of the vein. The other end of the artery connection section is integrally formed with the vein connection section and communicates therewith. An enlargement for preventing stenosis and thromboses is formed at the connection of the artery connection section and the vein connection section. The dialysis graft further includes lines, ring markings, and markings for providing a visual help to a physician when endovascular therapy is needed. 1. A dialysis graft comprising:a vein connection section having first and second ends and including a smooth outer surface adapted to slip and connect to two sections of a vein respectively;an artery connection section extending out of an intermediate portion of the vein connection section and communicating therewith, the artery connection section and the vein connection section forming a dialysis graft of T-shape, the artery connection section having a length greater than that of the vein connection section, the artery connection section having a third end connected to the artery, and the artery connection section being inclined at an angle with respect to the vein connection section at the connection to an artery to define an acute angle side and an obtuse angle side; andan enlargement for preventing thromboses formed at the obtuse angle side of the connection;wherein each of the artery and vein connection sections include marked lines on both sides on outer surface respectively, and each line has a plurality of equally spaced markings along its length;wherein each of the lines of the artery connection section and the corresponding one of the lines of the vein connection section are joined at the enlargement;wherein each of the artery and vein ...

SIDE TO SIDE ANASTOMOSIS

The invention relates to an assembly comprising on the one hand a graft vessel and on the other hand an anastomosis has connector. The connector comprises a ring and two pins. Each pin has a free end and a fixed end connected to the ring. The pins extend, viewed from the fixed end towards the free end, next to and set apart from each other. Each pin has an overlap section where the pin, viewed in axial direction of the ring, overlaps the plane bounded by the outer contour of the ring. The axial axis of the ring extends transverse to the wall of the graft vessel. The connector is attached to the graft vessel and the ring lies, with its full circumference, against the wall of the graft vessel. The invention further relates to a method of providing such an assembly and a method of attaching such an assembly to a recipient vessel. 1. Assembly comprising an anastomosis connector for use with a graft vessel;wherein the connector comprises a ring and two pins;each pin having a free end and a fixed end connected to the ring;the pins extending, viewed from the fixed end towards the free end, next to and set apart from each other;each pin having an overlap section where the pin, viewed in axial direction of the ring, overlaps the plane bounded by the outer contour of the ring;wherein the pins are arranged outside the graft vessel;wherein the axial axis of the ring extends transverse to the wall of the graft vessel;wherein the connector is attached to the graft vessel; andwherein the ring lies, with its full circumference, against the wall of the graft vessel.2. Assembly according to claim 1 , wherein the graft vessel is separated from a human or animal body.3. Assembly according to claim 1 , wherein the wall of the graft vessel defines an opening surrounded by the ring.4. Assembly according to claim 3 , wherein the opening has been formed by laser cutting an opening into the wall of the graft vessel.5. Assembly according to claim 1 , wherein the connector is attached to the ...

Prosthesis for connecting an anatomical duct

According to the invention, the tubular prosthesis for connecting an anatomical duct includes at least two individual tubular elements and a sealed mechanical element for connecting said separate elements to each other.

SYSTEMS FOR IMPLANTING AND USING A CONDUIT WITHIN A TISSUE WALL

Various embodiments of the present invention provide a conduit system including an outer lumen (), an inner lumen (), and an attaching device (). In other embodiments, a multiple access port device adapted for communication with at least one of an outer lumen, an inner lumen, or an attaching device of a conduit system is provided. In yet other embodiments, a system including an inner lumen that is collapsible is provided. Means for closing a conduit system are also provided, including a plug for insertion through an attaching device and a variable radius coiled member associated with an attaching device. 135.-. (canceled)36. A system for using a conduit device through a tissue wall of a patient , comprising:an outer lumen;an inner lumen adapted for insertion at least partially through the outer lumen;an attaching device in communication with a distal end of one of the outer lumen or the inner lumen, wherein the attaching device is adapted for securing to or inserting at least partially through the tissue wall; anda flow control mechanism configured to permit the passage of medical instruments therethrough.37. The system of claim 36 , wherein the outer lumen comprises one or more flow control mechanisms.38. The system of claim 36 , wherein the inner lumen comprises one or more flow control mechanisms.39. The system of claim 36 , further comprising a multiple access port device in communication with at least one of the outer lumen or the inner lumen claim 36 , wherein the multiple access port device includes a plurality of individual ports in fluid communication with the outer lumen or the inner lumen.40. The system of claim 36 , wherein the flow control mechanism comprises a flow control diaphragm valve comprising:a first conduit having proximal and distal ends;a flexible conduit attached in fluid communication at the distal end of the first conduit; anda second conduit attached in fluid communication at a distal end of the flexible conduit;wherein relative twisting ...

Devices and Methods for Limiting a Depth of Penetration for an Anchor within an Anatomy

The present disclosure includes a securing device comprising one or more barbs. A barb may comprise a depth stop, which may itself comprise an apex portion coupled to a trough portion. A barb may be constructed, in various embodiments, from a length of shape memory wire. Thus, during deployment, a barb may spring away from a medical device to which the barb is coupled such that the barb makes contact with and punctures, to a limited depth, a body lumen wall. A barb may not, however, fully puncture a body lumen wall. Rather, a depth stop may limit a puncture depth to a depth that does not endanger and/or subject tissue surrounding or external to the lumen wall to damage and/or bleeding or leakage from within the lumen. In various embodiments, a pair of barbs may be coupled to from an integral two pronged barb. 1. A medical securing device , comprising:a barb, the barb comprising a pointed tip and a depth stop, the depth stop comprising an apex portion coupled to a trough portion, wherein the depth stop limits a depth of penetration of the barb into a body lumen wall.2. The medical securing device of claim 1 , wherein the trough portion is coupled to one of: a stent or a stent graft.3. The medical securing device of claim 1 , wherein the barb is coupled to one of: stent or a stent graft.4. The medical securing device of claim 1 , the barb further comprising a length of shape memory wire.5. The medical securing device of claim 1 , wherein the barb is capable of springing away from a medical device to which the barb is secured during deployment.6. The medical securing device of claim 1 , wherein the depth stop comprises an “S” shape.7. The medical securing device of claim 1 , wherein the pointed tip is constructed to a specific length based upon a body lumen wall thickness.8. A barb constructed from a length of shape memory wire and comprising a pointed tip coupled to a depth stop claim 1 , the depth stop limiting a depth of penetration of the barb into a body lumen.9. ...

Open surgery anastomosis device, system, and method

A medical device, system and method tor an open surgical procedure configured to couple, for example, open ends of anatomical structures. The system includes an expandable tubular structure and inflatable balloon positioned within the tubular structure. The tubular structure includes a lateral opening defined in a wall of the tubular structure through which the balloon is inflated to radially expand the tubular structure, after which the balloon is deflated, and then removed from the tubular structure to, thereby, provide a fluid flow path through the tubular structure.

Devices and systems for retaining a medical device at a treatment site

In accordance with various embodiments, an anchoring system for a medical device comprises one or more biased hooks. The one or more biased hooks may be formed by any suitable process. Moreover, the one or more biased hooks may be formed from a shape memory material. The anchoring system may be processed in any suitable way to provide a designed or predefined failure mode. This failure mode may be designed to protect or prevent damage to the medical device. The anchoring system may be configured with a plurality of hooks biased in various directions. Moreover, the anchoring system may be configured with a plurality of substantially small hooks configured to engage the anatomy at multiple points. As such, the anchoring systems may be customizable and provide for an implantable medical device with a reduced delivery geometry and/or deployment geometry.

Anastomotic connector and system for delivery

An anastomotic connector comprises a vessel anchor, a midgraft connector and graft material. The vessel anchor has a generally tubular main body including a distal end and a proximal end, the distal end defining a plurality of flanges integrally formed with the tubular main body and being movable from a first loaded position to a second expanded position. The midgraft connector operably couples the graft to the vessel anchor to form an anastomotic connector between an artery and a vein.

Anastomotic devices and methods

Exemplary embodiments comprise AV fistulas and other anastomotic devices for creating new or reinforcing existing side-branch vessels, and/or bridging neighboring vessels together. An exemplary embodiment may comprise a sidewall port, such as a flanged sidewall port, and/or flow frame design, such as a partially bare, flexible stent or a whisk, for purposes of creating a transmural flow. Another exemplary embodiment may comprise a compliant vessel support to aid in the transition from device to vessel and/or vessel to device, and to promote vessel dilation.

Kink Resistant Graft Devices and Related Systems and Methods

A graft device including a conduit and a fiber matrix surrounding the conduit for a mammalian patient is disclosed. The graft device further includes a kink resisting element such that the graft device is configured to reduce kinking. Methods and systems for creating kink resistant graft devices are also provided.

EMERGENCY VASCULAR REPAIR PROSTHESIS

A prosthesis system for repair of a transected body vessel is provided. The system can include first and second prostheses each including a tubular graft body and a support structure. Each prosthesis can be expandable between a compressed and an expanded configuration. In the expanded configuration, outer surfaces of the first and second prostheses can engage walls of the body vessel. The system can include a sleeve member formable into a tubular body. The first and second prostheses can be coupled to one another at a joint to form a coupled prosthesis. The sleeve member can receive the coupled prosthesis and cover the joint to inhibit leakage therefrom. The prosthesis system can connect first and second portions of the body vessel to permit blood flow therethrough. The sleeve member can be discrete to the coupled prosthesis or can have one end fixedly attached to the coupled prosthesis. 1. An emergency open surgical method of repairing a lacerated or transected blood vessel to obtain hemostasis while maintaining blood perfusion by interconnecting a first vessel portion and a second vessel portion of the lacerated or transected vessel , the method comprising:gaining open surgical access to the lacerated or transected vessel;introducing a first end of a first prosthesis in a compressed configuration into the first vessel portion such that a second end of the first prosthesis is exposed external to the first vessel portion;expanding the first prosthesis to an expanded configuration such that the first end of the first prosthesis engages a wall of the first vessel portion;introducing a first end of a second prosthesis in a compressed configuration into the second vessel portion such that a second end of the second prosthesis is exposed external to the second vessel portion;expanding the second prosthesis to an expanded configuration such that the first end of the second prosthesis engages a wall of the second vessel portion;coupling the second end of each of the first ...

Combinatorial therapies including implantable damping devices and therapeutic agents for treating a condition and associated systems and methods of use

Devices, systems, and methods for combinatorial treatment of a condition with an implantable damping device and therapeutic agent (e.g., drug) are disclosed herein. Methods for treating one or more effects of the condition, such as a neurological condition, include providing the implantable damping device and at least neck one other therapy, such as a therapeutic agent, that treats the condition to the patient. The implantable damping device includes a flexible damping member and an abating substance and can be placed in apposition with a blood vessel. The flexible damping member forms a generally tubular structure having an inner and an outer surface, the inner surface formed of a sidewall having a partially deformable portion. The abating substance is disposed within the partially deformable portion and moves longitudinally and/or radially within the partially deformable portion in response to pulsatile blood flow.

AORTIC STENT-GRAFT

An aortic stent-graft capable of avoiding migration of location, which includes a covered stent body and a bare stent connected to a proximal end of the covered stent body, with barbs for looseness-proof fixation which are provided at each wave crest and each wave trough of the bare stent and extend towards a distal end of the covered stent body. After the aortic stent-graft is fastened by the looseness-proof fixation structures, because the barbs arranged at each wave crest of the bare stent are not on the same plane with the barbs arranged at each wave trough of the bare stent, simultaneous relative motions of the two sets of barbs which may lead to detachment or loosening of the looseness-proof fixation structures will not happen, so that the aortic stent-graft is able to be fastened onto a blood vessel wall more firmly. 121-. (canceled)22. An aortic stent-graft , comprising:a covered stent body; anda waved bare stent connected to a proximal end of the covered stent body, with a first looseness-proof fixation structure provided at each wave crest of the bare stent away from the covered stent body, wherein,a second looseness-proof fixation structure is provided at each wave trough of the bare stent near the covered stent body,the first looseness-proof fixation structure and the second looseness-proof fixation structure extending towards a distal end of the covered stent body are outspreading barbs,two barbs are provided at each wave crest of the bare stent, and an intersection angle is formed between the two barbs,the aortic stent-graft is an abdominal aortic stent-graft.23. The aortic stent-graft of claim 22 , wherein claim 22 , one barb is provided at each wave trough of the bare stent claim 22 , and the barb is arranged on an outer surface of a handle portion for connecting each wave trough to a connection hole.24. The aortic stent-graft of claim 22 , wherein claim 22 , the barbs are integrally formed on the bare stent.25. The aortic stent-graft of claim 22 , ...

ENDOVASCULAR PERFUSION STENT GRAFT

An endovascular perfusion stent graft is provided that can include a graft device, a balloon and a valve. The graft device can be inserted into a vessel. The balloon can be inserted into the graft device and can temporarily restrict passage of fluid or gas received via a perfusion port when the balloon is inflated via a bulb that provides air pressure to the balloon. The perfusion port can be operatively connected to another perfusion port configured to allow the fluid or the gas to pass through another balloon. The valve can be attached to the graft device. 1. A system , comprising:a graft device configured to be inserted into a vessel;a balloon configured to be inserted into the graft device and to temporarily restrict passage of fluid or gas received via a perfusion port when the balloon is inflated via a bulb that provides air pressure to the balloon, wherein the perfusion port is operatively connected to another perfusion port configured to allow the fluid or the gas to pass through another balloon; anda valve configured to be attached to an end of the graft device.2. The system of claim 1 , wherein the valve is configured to be attached at a distal end of the graft device.3. The system of claim 1 , wherein the valve is configured to open and close to provide unidirectional flow of the fluid or the gas.4. The system of claim 1 , wherein the valve is selectively removable from the graft device.5. The system of claim 1 , wherein the valve is a wire mesh valve attached to the end of the graft device.6. The system of claim 1 , wherein the valve is a mechanical valve attached to the end of the graft device.7. The system of claim 1 , wherein the valve is a bioprosthetic valve attached to the end of the graft device.8. The system of claim 1 , wherein the bulb is configured to provide the air pressure to the balloon through a balloon infusion port.9. The system of claim 1 , further comprising:another graft device configured to be inserted into another vessel, wherein ...

LOCKING MECHANISM FOR SECURING THE INTERFACE BETWEEN STENT GRAFTS

A modular stent graft system and methods of assembly are disclosed. The stent graft assembly comprises a first stent graft having an interface region at its distal end and a first locking stent secured to an internal surface of the interface region. A second stent graft having an interface region at its proximal end is configured to at least partially overlap with the interface region at the distal end of the first stent graft. The second stent graft comprises a second locking stent secured to an external surface of the interface region. The first and second locking stents are configured to be engaged such that the second locking stent is nested between the first locking stent and an internal surface of the interface region of the first stent graft thereby interlocking the first and second stent grafts to each other. 1. A modular stent graft system comprisinga first stent graft comprising a first tubular body of biocompatible graft material, a proximal end, a distal end, an internal lumen, and an inner interface region at the distal end having an internal surface;a locking stent secured to the internal surface of the inner interface region, the locking stent having a first end, a second end, proximal apices, distal apices, and a locking mechanism at one of the ends of the locking stent having an unattached free end that extends away from the internal surface and inwardly into the internal lumen;a second stent graft comprising a second tubular body of biocompatible graft material, a proximal end, a distal end, and an outer interface region having an external surface at the proximal end configured to at least partially overlap with the inner interface region of the first stent graft;at least one stent secured to the external surface of the outer interface region, the at least one stent comprising a series of proximal apices and a series of distal apices, wherein when the inner interface region and outer interface region are in at least a partial overlapping ...

DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE

The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided. 1109-. (canceled)110. A method for preventing stenosis of a vein , a graft , an artery , a vessel , and an anastomotic orifice at an anastomosis site having an extravascular surface , comprising the steps of:a. Providing a stent comprising a structure defining an essentially tubular body having a tubular wall with a longitudinal axis and a circumferential diameter, the structure being expandable from a contracted configuration to an expanded configuration, wherein the stent is beveled at the edge and curved along the longitudinal axis for placement in the anastomosis site;b. Providing a sleeve comprising a biocompatible matrix material imbibed with a therapeutic agent;c. Applying the sleeve to the extravascular surface of the anastomosis site; andd. Inserting the stent into the vein and the anastomotic orifice of the anastomosis site.111. The method of claim 110 , wherein the therapeutic agent is rapamycin.112. The method of claim 110 , wherein the therapeutic agent is an analogue of rapamycin.113. The method of claim 110 , wherein the ...

APPARATUS AND METHOD FOR FORMING A HOLE IN A HOLLOW ORGAN

The invention relates to an apparatus and method for forming a hole in a wall of a hollow organ. The applicator includes a hole forming element for forming a hole in the wall of the organ, a positioning means for positioning the hole forming element, and a retractor element. In addition, the applicator includes a sequencing means for coordinating the relative movement of the retractor element and the hole forming element in a sequential manner to thereby carry out a procedure for forming a hole in the wall of the hollow organ. The sequencing means may further include a safety latch element operatively coupled to the retracting means and the hole forming element. The safety latch of the invention keeps prevents damage to the internal surface of the organ during the formation of the hole. 116-. (canceled)17. A method of forming a hole in a wall of a hollow organ comprising:forming a hole in the wall of the organ with a hole forming element, the hole forming element having a cutting element on a distal end thereof;positioning the hole forming element with a positioning means coupled to the hole forming element, the positioning means being operatively coupled to a retractor element; andcoordinating the relative movement of the retractor element with respect to the hole forming element in a sequential manner with a sequencing means to thereby carry out a procedure for forming a hole in the wall of the hollow organ.18. The method of claim 17 , wherein the retractor element comprises a retractor body movably disposed within the hole forming element and an expansion element disposed on a distal end of the retractor body claim 17 , the expansion element being expandable.19. The method of claim 18 , wherein the expansion element is expandable from an unexpanded state to claim 18 , fully expanded state and to a partially expanded state.20. The method of claim 19 , wherein the sequencing means controls the expansion of the expansion element from the unexpanded state claim 19 , ...

Implantable tissue connector

An implantable tissue connector comprises a conduit and at least one bulge extending outwardly from the conduit's outer surface in a circumferential direction. At least one blocking ring loosely fitting over the outer surface with a clearance between the outer surface and the blocking ring is provided for mounting tubular living tissue within the clearance. The blocking ring has an inner diameter which is sized relative to an outer diameter of the bulge to prevent the blocking ring from slipping over the bulge when living tissue is mounted within the clearance. During implantation, the conduit is inserted into the tubular part of living tissue and over the bulge. Then, the blocking ring is pushed over the free end of the living tissue against the bulge. The living tissue is secured to the conduit with a self-enhancing effect when the tissue tends to be pulled off of the conduit

LONGITUDINALLY AND RADIALLY FLEXIBLE ANASTOMOSIS STENT

An anastomosis stent includes an elongated body of a tubular configuration having a length and diameter dimensions extending in axial and radial directions of the elongated body and in a transverse relationship to each other. The elongated body is formed by multiple rings stacked adjacent one another in a direction parallel to the length dimension. Each ring is a single strand of wire bent in a repetitive pattern of sine waves. Each sine wave defines an alternating peak and valley divided by a length dimension extending orthogonal to the length dimension of the elongated body. The rings are fused together at locations on selected pairs of adjacent peaks and valleys of the rings with the fused locations arranged in parallel rows. The elongated body includes main and end portion and a safety mark about the elongated body at the juncture therebetween. 1. An anastomosis stent , comprising:an elongated body of a tubular configuration and having a length dimension extending in an axial direction of said elongated body and a diameter dimension extending in a radial direction of said elongated body being in a transverse relationship to said axial direction of said elongated body;said elongated body being formed by a multiplicity of rings stacked adjacent to one another in a direction parallel to said length dimension of said elongated body, each of said rings being formed by a single strand of wire bent in a repetitive pattern of sine waves;each of said sine waves defining an alternating peak and valley divided by a length dimension extending orthogonal to said length dimension of said elongated body; andsaid multiplicity of rings being fused to one another at locations on selected pairs of adjacent peaks and valleys of said sine waves in said single strand of wire of each of said rings so as to provide flexibility of said rings in said radial direction relative to said axial direction of said elongated body.2. The anastomosis stent of wherein said single wire of each of ...

A Kit for Placing a Bypass

A kit for placing a bypass between two body vessels (R, L) of a patient comprises two catheters (), two guide wires () moveable within one of the catheters () each and a bypass element delivery system () for holding a bypass element (). The bypass element delivery system () is moveable along the first guide wire () and the bypass element delivery system () is capable of releasing and setting free the bypass element (). The kit further comprises an expansible element () being capable of connecting with the bypass element delivery system (), of moving the bypass element delivery system () towards the opposite end of the first guide wire () and of setting the bypass element delivery system () free. The inventive kit enables an atraumatic placement of a bypass. 1. A kit for placing a bypass between a first and a second body vessel of a patient , the kit comprisinga first catheter with a first delivery end and a second catheter with a second delivery end,a first guide wire moveable within the first catheter, the first guide wire having a first end region being moveable to the first delivery end, the first guide wire having an opposite end being opposite to the first end region,a second guide wire moveable within the second catheter, the second guide wire having a second end being moveable to the second delivery end, the second end of the second guide wire being a catch for capturing the first guide wire and for moving the first guide wire into the second catheter with a first end region of the first guide wire first, anda bypass element delivery system for holding a bypass element, the bypass element delivery system being moveable along the first guide wire from the first end region of the first guide wire, wherein the bypass element delivery system is capable of releasing and setting free the bypass element,wherein the kit comprises an expansible element the expansible element being capable of connecting with the bypass element delivery system and of moving the bypass ...

Method and apparatus for coupling left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions

A method for stimulation of collateral development in ischemic cardiac regions comprises the fluid coupling of the left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes a control of the diastolic/systolic pressure in the venous system to be within about 20 - 50 mmHg. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes inserting a transmyocardial conduit into the left ventricle and a tri-directional coupler attached to the anterior interventricular vein. An associated apparatus for stimulation of collateral development in ischemic cardiac regions via the fluid coupling of the left ventricle of the heart to the anterior interventricular vein is disclosed.

Magnetically Activated Arteriovenous Access Valve System and Related Methods

In one aspect, an arteriovenous access valve system may generally include a first valve configured to be positioned at or adjacent to an end of arteriovenous graft and a second valve configured to be positioned at or adjacent to an opposite end of the arteriovenous graft. In addition, the system may include an actuator assembly in fluid communication with the first and second valves. The actuator assembly may include a housing, a driver assembly positioned within the housing and a drive magnet positioned within the housing. The drive magnet may be rotatably coupled to the driver assembly such that, when the drive magnet is rotated, the driver assembly is configured to be rotatably driven so as to supply fluid to the first and second valves or to draw fluid out of the first and second valves depending on a rotational direction of the driver assembly.

Implanted Extracardiac Device for Circulatory Assistance

This invention is an implanted extracardiac device for supplementing blood circulation which comprises an implanted blood flow lumen, a blood flow increasing mechanism, and a control unit. Its design improves blood circulation when the blood flow increasing mechanism is operating, without hindering native blood flow when the mechanism is not operating. This device improves circulation without intruding on cardiac tissue or weakening the heart by completely supplanting cardiac function. Also, since the device allows native blood flow when the blood flow increasing mechanism is not in operation, it requires less power and can enable more patient mobility. 1. An implanted extracardiac device for supplementing blood circulation comprising:at least one implanted blood flow lumen, wherein this implanted blood flow lumen is configured to be implanted within a person's body so as to receive blood inflow from a blood vessel at an upstream location with respect to the natural direction of blood flow, wherein this implanted blood flow lumen is configured to discharge blood into a blood vessel at a downstream location with respect to the natural direction of blood flow, wherein this implanted blood flow lumen has a longitudinal axis spanning from the upstream location to the downstream location, wherein this implanted blood flow lumen has a cross-sectional area through which blood can flow which is substantially perpendicular to the longitudinal axis, and wherein a minimum cross-sectional flow area is defined as the minimum unobstructed cross-sectional area through which can blood flow from the upstream location to the downstream location;a blood flow increasing mechanism, wherein this blood flow increasing mechanism is configured to be implanted within a person's body, wherein this blood flow increasing mechanism is configured to increase the flow of blood from the upstream location to the downstream location when the blood flow increasing mechanism is in operation by ...

SYSTEMS FOR IMPLANTING AND USING A CONDUIT WITHIN A TISSUE WALL

Various embodiments of the present invention provide a conduit system including an outer lumen, an inner lumen, and an attaching device. In other embodiments, a multiple access port device adapted for communication with at least one of an outer lumen, an inner lumen, or an attaching device of a conduit system is provided. In yet other embodiments, a system including an inner lumen that is collapsible is provided. Means for closing a conduit system are also provided, including a plug for insertion through an attaching device and a variable radius coiled member associated with an attaching device. 135-. (canceled)36. A device for attaching to a tissue wall having a first surface and a second surface , the device comprising:a port defining an opening extending along a longitudinal axis of the device; anda plurality of coils fixedly attached to the port and configured for advancing at least partially through the tissue wall such that at least a portion of each coil becomes disposed between the first surface and the second surface of the tissue wall, wherein the coils are centered on a common rotational axis.3735. The device of claim , wherein the opening of the port extends from a proximal end to a distal end of the port in a direction of the longitudinal axis of the device.38. The device of claim 37 , wherein the coils each extend distally beyond the distal end of the port.39. The device of claim 36 , wherein the common rotational axis of the coils is coaxial with the longitudinal axis of the device.40. The device of claim 36 , wherein the coils each have a radially expanding helical shape.41. The device of claim 36 , further comprising a flange extending about the port and configured for engaging the tissue wall.42. The device of claim 36 , further comprising a plug configured for releasably attaching to the port and for positioning at least partially within the opening of the port.43. The device of claim 42 , wherein the plug comprises a valve configured for ...

SYSTEM AND METHOD FOR SCAFFOLDING OF ANASTOMOSES

Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing. 1. A method for healing of an anastomosis in a target body lumen , the method comprising:positioning a prosthetic scaffold at an anastomotic site in the target body lumen;radially expanding the prosthetic scaffold to engage a wall of the target body lumen;utilizing the prosthetic scaffold to apply a compressive force on the wall of the target body lumen to maintain opposing like tissue layers of the anastomosis in substantial alignment; andretaining the prosthetic scaffold at the anastomotic site during a period of anastomotic healing.2. The method of claim 1 , wherein the prosthetic scaffold includes a barrier layer claim 1 , the method further comprising:engaging the barrier layer with the wall of the target body lumen to form a fluidic seal between the anastomosis and the barrier layer.3. The method of claim 1 , wherein the prosthetic scaffold includes a biological agent claim 1 , the method further comprising:delivering the biological agent to the anastomotic site to facilitate healing of the anastomosis.4. The method of ...

VASCULAR PROSTHESIS

A vascular prosthesis configured for direct connection to an artery. The vascular prosthesis may include a tube of material other than autologous vascular tissue, having an end formation, which is configured for surgical connection to an opening formed in the artery, and a narrower portion prior to commencement of the end formation. The end formation may have an enlarged chamber adapted to induce a concave section in said blood vessel upon attachment thereto. 2. The vascular prosthesis according to wherein the enlarged chamber is configured to promote localized movement of blood having a non-laminar nature with a shear stress inducing relationship to a wall of the blood vessel.3. The vascular prosthesis according to wherein a transition between the generally tubular portion and the heel is generally outwardly concave.4. The vascular prosthesis according to wherein opposing sides of the second diameter are generally outwardly convex.5. The vascular prosthesis according to further comprising a narrow section positioned between the generally tubular portion and the end formation claim 4 , wherein a diameter of the narrow section is less than a diameter of the generally tubular portion.6. The vascular prosthesis according to the generally tubular portion having a second end formation at an end of the generally tubular portion opposite the end formation.7. The vascular prosthesis according to wherein the second end formation comprises a second enlarged chamber having a first diameter parallel to the axis of the generally tubular portion and a second diameter transverse to the axis of the generally tubular portion claim 6 , wherein the first diameter is longer than the second diameter claim 6 , the first diameter comprising a heel and a toe claim 6 , wherein a transition between the generally tubular portion and the toe is outwardly initially convex before a final concave portion.8. The vascular prosthesis according to wherein a transition between the generally tubular ...

Systems and methods for a fluid carrying conduit of a vascular access system

Systems and methods for a blood conduit for fluidly coupling a first vascular segment to a second vascular segment are disclosed herein. In one embodiment, a system for fluidly coupling proximal and distal tubular segments of a fluid conduit in a cardiovascular system is provided. The system may include a first engagement feature disposed on a distal end of the proximal tubular segment. The system also may include a second engagement feature disposed on a proximal end of the distal tubular segment. The first engagement feature may be configured to mate with the second engagement feature. In this manner, continuous flow may be provided between the proximal and distal tubular segments of the fluid conduit. In another embodiment, the proximal and distal tubular segments of the fluid conduit may collectively form a single unitary lumen without a connection device interposed between the segments.

VASCULAR CONDUIT DEVICE AND SYSTEM FOR IMPLANTING

The present invention provides a vascular conduit device including a deformable flange and complementary securing ring in cooperation for securing the device within an aperture defined in a tissue wall. The present invention further provides a system for implanting such a vascular conduit device in a tissue wall. More specifically, the present invention provides a system including a coring device for defining an aperture in a tissue wall (such as a ventricle and/or a blood vessel) and securely implanting a vascular conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the vascular conduit device. 124-. (canceled)25. A system comprising: a tube defining a lumen extending along an axis defined by the tube from a proximal end to a distal end of the tube, the tube configured for insertion within an aperture of the tissue wall extending from the first surface to the second surface of the tissue wall;', 'a flange attached to the tube and extending outward from an outer surface of the tube, the flange configured for engaging the first surface of the tissue wall; and', 'a ring attached to the tube and extending outward from the outer surface of the tube, the ring configured for engaging the second surface of the tissue wall; and, 'a conduit device configured for providing fluid communication between a first surface and a second surface of a tissue wall, the conduit device comprisinga cap configured for selectively engaging the tube such that the cap seals the proximal end of the tube.26. The system of claim 25 , wherein the cap comprises a pawl member configured for selectively engaging ridges of the tube.27. The system of claim 25 , wherein the cap comprises threads configured for selectively engaging mating threads of the tube.28. The system of claim 25 , wherein the flange is disposed at or near the distal end of the tube.29. The system of claim 25 , wherein the flange is integrally formed with the tube.30. ...

Catheter-Based Fastener Implantation Apparatus and Methods

Apparatus and methods utilize an intraluminal fastener applier having a guide body with a longitudinal axis. The guide body is sized and configured for intraluminal deployment in a hollow body organ. An actuated assembly is carried by the guide body that is selectively operable to generate an implantation force to implant at least one fastener into tissue within the hollow body organ. The actuated assembly includes a driven member extending generally along the longitudinal axis, which is sized and configured to engage a selected fastener. The actuated assembly also includes a drive member coupled to the driven member to impart the implantation force to the driven element in a direction that is at an angle to the longitudinal axis of the guide body.

GREAT VESSEL GRAFT SUTURING AID

A stabilization tool supports a blood vessel for suturing during cardiovascular surgery. The support vessel may typically be part of an artificial graft used in replacing an aortic arch. The stabilization tool has a central shaft with a mounting element at a first end. A plurality of retractable arms have their distal ends affixed to a second end of the central shaft. The retractable arms are movable between a nested position flanking the central shaft and a range of extended positions wherein proximal ends of the retractable arms are spaced away from the central shaft. A closing ring is slidable over the retractable arms from a deployed position adjacent the second end of the central shaft to a retracted position spaced away from the second end to move the retractable arms. 1. A stabilization tool for suturing a vessel , comprising:a central shaft having a mounting element at a first end;a plurality of retractable arms having distal ends affixed to a second end of the central shaft, wherein the retractable arms are movable between a nested position flanking the central shaft and a range of extended positions wherein proximal ends of the retractable arms are spaced away from the central shaft; anda closing ring slidable over the retractable arms from a deployed position adjacent the second end of the central shaft to a retracted position spaced away from the second end.2. The stabilization tool of further comprising:a control ring mounted on the central shaft between the retractable arms and the first end adapted to slide along the central shaft under manual control; anda push-pull cable connecting the control ring and the closing ring so that motion of the control ring is replicated by the closing ring to reconfigure the retractable arms between the nested position and an extended position within the range of extended positions.3. The stabilization tool of wherein the central shaft includes an intermediate bend between the retractable arms and the control ring.4. ...

Endovascular anastomotic connector device, delivery system, and methods of delivery and use

An endovascular anastomotic connector and method of using the same. The endovascular anastomotic connector includes a vascular conduit and a supply conduit. The vascular conduit has proximal and distal ends that reside within a vascular structure. The supply conduit extends at an angle from the vascular conduit. The proximal end of the supply conduit is configured to be attached to an auxiliary device.

DEVICES AND METHODS FOR EFFECTUATING PERCUTANEOUS GLENN AND FONTAN PROCEDURES

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other. 1. A radially self-expanding endograft prosthesis comprising:a distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall;a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall;a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend;a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other, the proximal segment being sufficiently stiff to seat within and urge against a vessel wall; anda proximal end including a plurality of openings around the ...

VENTRICULAR ASSIST DEVICE AND RELATED METHODS

A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery. 1. A system to assist a left ventricle of a heart , the system comprising:an anastomosis device coupled to a septum between two chambers of the heart and providing a flow path between the two chambers;a flow path including at least one conduit and configured to flow oxygenated blood from at least one of the left atrium and the left ventricle, through the anastomosis device, through the superior vena cava and back to an artery;a pumping device coupled with the at least one conduit; anda filament coupled to the anastomosis device, wherein the filament exhibits sufficient length to extend from the anastomosis device through the superior vena cava and to an access point associated with at least one of a jugular vein and a subclavian vein.2. The system of claim 1 , wherein the at least one conduit includes:a first conduit coupled with the anastomosis device and extending through the superior vena cava; anda second conduit extending through one of a brachial artery, a carotid artery, a subclavian artery, and a axillary artery and having an outlet disposed in an aortic artery.3. The system of claim 2 , wherein the pumping device is coupled between the first conduit and the second conduit.4. The system of claim 1 , wherein the pumping device is coupled between the anastomosis device and the at least one conduit.5. The system of claim 1 , wherein the pumping device is coupled directly to the anastomosis device.6. The system of claim 1 , wherein the anastomosis device is shaped and configured to be substantially flush with a left wall of the septum.7. The system of claim 1 , wherein a portion of the anastomosis device protrudes past a left wall of the septum claim 1 , and ...

Vascular Prosthesis

A vascular prosthesis (1) for connection to a natural cardiovascular system, includes a volume chamber (2), wherein the volume chamber (2) has, in a blood pressure range below a pressure threshold value D, a pressure-expansion behavior substantially corresponding to the pressure-expansion behavior of a natural blood vessel, while the volume of the volume chamber (2), depending on the pressure, increases by at least 10 cm3 in a blood pressure range above the pressure threshold value D. The vascular prosthesis (1) is configured as a textile tube, wherein the textile tube includes in the region of the volume chamber (2) an elastic yarn having a core made from silicone yarn around which a yarn made from polyethylene terephthalate (PET) is wrapped.

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage. 1. (canceled)2. A method of diverting fluid flow from a first vessel to a second vessel in a limb , the method comprising:inserting a first catheter in the first vessel;inserting a second catheter in the second vessel;deploying a needle from the first catheter, through tissue between the first vessel and the second vessel, and into the second vessel; and a first end portion having a first end diameter sized to correspond to a diameter of the first vessel,', 'a second end portion having a second end diameter sized to correspond to a diameter of the second vessel, and', 'an intermediate portion between the first end portion and the second end portion,, 'deploying a device in the first vessel, the second vessel, and the tissue between the first vessel and the second vessel, the device comprising expanding the first end portion coaxial with and against sidewalls of the first vessel, wherein expanding the first end portion comprises self-expanding the first end portion,', 'expanding the intermediate portion, wherein expanding the intermediate portion comprises self-expanding the intermediate portion, and', 'expanding the second end portion coaxial with and against sidewalls of the second vessel, wherein expanding the second end ...

Delivery system for implantable flow connector

A delivery system for delivering an implant to a first space within a body of a patient including an elongate delivery member having a proximal portion, a distal portion, a lumen and a receiving area, the receiving area dimensioned for receipt of the implant. A deforming member is movable with respect to the delivery member from a first position to a second position to apply a force to the implant to deform the implant positioned in the receiving area of the delivery member.

Implantable and removable customizable body conduit

An apparatus and method are provided to treat a stenosis. A delivery device is provided that has an elongate tubular member coupled therewith. The elongate tubular member has an outside surface that is configured to prevent adherence of in vivo matter. The tubular member has a proximal end and a distal end and is reinforced along its length to maintain open lumen under a transverse load. The tubular member is placed in the vasculature such that the distal end of the elongate tubular member is disposed distal of a stenosis. The proximal end of the elongate tubular member is disposed inside the vessel, preferably at a location proximal of the stenosis. Thereafter, after a therapeutic period, the elongate tubular member is removed intact.

Medical connector device

The present invention provides devices for connecting biological structures. The device features a tubular member that includes a tubular body. The tubular member may include a plurality of interwoven lengths configured for reversible radial enlargement and reversible radial contraction of the tubular member. In some aspects the tubular member may include a net design of interconnected cells configured for reversible radial enlargement of the tubular member. The tubular member includes a distal opening, a proximal opening, a central cavity within the tubular member for receiving and retaining a biological structure and a plurality of spaced apart protrusions protruding out from the exterior surface of the body of the device for fixing to the device an end of the biological structure and for fixing a second structure to the device to facilitate connecting the biological structure to the second structure.

ENDOVASCULAR STENT GRAFT ASSEMBLY AND DELIVERY DEVICE

A pre-loaded delivery device that facilitates accurate placement of a stent graft assembly in the aorta is disclosed. A stent graft is carried on the delivery device and held in a pre-deployment configuration by a sheath. A split in the sheath facilitates the pre-cannulation of one or more branch arteries extending from the aorta before the stent graft is fully released in the aorta. The stent graft comprises a tubular body having at least one scalloped fenestration formed in one end of the graft material and at least one fenestration formed in the graft material of the main tubular body. A helical internal side branch extends from the fenestration within the lumen of the main tubular body. The helical side branch is configured to curve at least partially around the scalloped fenestration. The assembly further comprises a connection stent graft extending from the fenestration into a branch vessel. 1. A system for the delivery and deployment of an endovascular stent graft comprising:a delivery device having a longitudinal axis comprising a pusher catheter having a proximal end and a distal end and defining a lumen extending between the proximal and distal ends and a guide wire catheter extending longitudinally within the lumen of the pusher catheter;a stent graft releasably coupled to the delivery device,a sheath having a proximal end and a distal end, wherein the sheath is disposed over the stent graft thereby retaining the stent graft in a radially contracted configuration on the delivery device, the sheath comprising a split located between the proximal and distal ends of the sheath thus forming a distal sheath segment located distal of the split and a proximal sheath segment located proximal of the split; andan auxiliary catheter having a proximal end and a distal end and defining a guide wire lumen therebetween, wherein the auxiliary catheter extends longitudinally under the distal sheath segment and through the sheath split between the proximal and distal ...

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage. 1. (canceled)2. A device comprising:a longitudinal axis;a first end portion having a terminal first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being self-expanding;a second end portion having a second end diameter smaller than the terminal first end diameter, the second end portion being substantially cylindrical, the second end portion having a second length along the longitudinal axis, the second end portion being self-expanding;an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end portion and the second end portion, the intermediate portion having a third length along the longitudinal axis, the first end portion being frustoconical, the first end portion tapering between the terminal first end diameter and the intermediate portion; anda graft material coupled to at least the intermediate portion, the device configured to provide fluid flow between a first passage in which the first end portion is anchored and a second passage in which the second end portion is anchored.3. The device of claim 2 , wherein each of the first end portion claim 2 , the second end portion claim 2 ...

Devices, methods and systems for counterpulsation and blood flow conduit connection

A blood flow conduit includes a first conduit portion defining a first portion of a lumen and blood flow path, and a second conduit portion defining a second portion of a lumen and blood flow path. The first portion of the lumen has a smoother surface for contacting the blood flow than the second portion of the lumen. A discontinuity such as a tip portion is positioned between the first and second portions of the lumen.

CARDIOVASCULAR VALVE AND VALVE HOUSING APPARATUSES AND SYSTEMS

A cardiovascular valve assembly is disclosed including a housing assembly comprising a first portion and a second portion removably attached to the first portion. A valve may be positioned within the housing assembly. The valve, which may be a mechanical valve, a biological tissue valve, or a polymeric valve, may be structured to allow fluid to flow through the housing assembly in a single direction. In certain embodiments, the valve assembly may further include at least one coupling structure provided on the second portion and at least one aperture defined in the first portion, with the aperture structured to receive the coupling structure to couple the first portion to the second portion. Corresponding systems incorporating cardiovascular valve assemblies are also disclosed. 123.-. (canceled)24. A cardiovascular system , comprising:a tube configured to connect to a tissue wall;a valve positioned within the tube;a cutting member within the tube, the cutting member being configured to cut tissue from the tissue wall to form an opening in the tissue wall;a tissue retraction member configured to remove the tissue cut by the cutting member from the tube; andan anchor extending from the tissue retraction member for anchoring to the tissue to be removed.25. The system of claim 24 , wherein the tube is configured to provide a sealed interface between the tissue wall and a cardiovascular device.26. The system of claim 24 , wherein the tube is cylindrical.27. The system of claim 24 , wherein the tube is sized and dimensioned for implanting to the tissue wall.28. The system of claim 24 , wherein the tube is elongated.29. The system of claim 24 , wherein the tube is configured to attach to the tissue wall.30. The system of claim 29 , wherein the tube is configured to attach to the tissue wall by sutures.31. The system of claim 29 , further comprising a conduit system comprising a conduit and a connector assembly claim 29 , wherein the connector assembly includes expandable ...

SELF-CLOSING DEVICES AND METHODS FOR MAKING AND USING THEM

A self-closing device for implantation within a patient's body includes base material including an inner surface area for securing the base material to a tissue structure, and a plurality of support elements surrounding or embedded in the base material. The support elements are separable laterally within a plane of the base material to accommodate creating an opening through the base material for receiving one or more instruments through the base material, and biased to return laterally towards a relaxed state for self-closing the opening after removing the one or more instruments. The device may be provided as a patch or integrally attached to a tubular graft or in various shapes. 1. A method for implanting an access device into a patient's body , comprising:providing an access device defining a first end, a second end, a longitudinal axis extending therebetween, and a wall including inner and outer surfaces and defining opposite side edges extending between the first and second ends, the access device comprising elastomeric base material, a plurality of elongate elastic elements embedded in the base material, the elastic elements being disposed adjacent one another and unconnected to adjacent support elements, and fabric covering the base material and the elastic elements, the elastic elements separable laterally to accommodate creating an opening through the base material when an instrument is introduced through the base material, and biased to return laterally towards a relaxed state for self-closing the opening after removing the instrument;exposing a body structure within a patient's body;separating the side edges of the access device to open the access device;positioning the access device adjacent the outer surface of the body structure; andreleasing the side edges such that the inner surface of the access device wraps at least partially around the body structure. andattaching the access device to the body structure.2. The method of claim 1 , wherein the body ...

METHOD AND APPARATUS FOR SUTURELESSLY CONNECTING A CONDUIT TO A HOLLOW ORGAN

An implantable connector for suturelessly connecting a conduit to a hollow organ, the implantable connector comprising: a hollow expandable stent, wherein the hollow expandable stent comprises an internal skeleton and a blood-retaining membrane covering the internal skeleton, and wherein the hollow expandable stent is constructed so that it is capable of assuming (i) a diametrically-reduced state for insertion into an opening formed in the side wall of the hollow organ in order to create a first interference fit therewith, and (ii) a diametrically-expanded state for expanding against the side wall of the hollow organ in order to create a second, enhanced interference fit therewith. 1. An implantable connector for suturelessly connecting a conduit to a hollow organ , the implantable connector comprising:a hollow expandable stent, wherein the hollow expandable stent comprises an internal skeleton and a blood-retaining membrane covering the internal skeleton, and wherein the hollow expandable stent is constructed so that it is capable of assuming (i) a diametrically-reduced state for insertion into an opening formed in the side wall of the hollow organ in order to create a first interference fit therewith, and (ii) a diametrically-expanded state for expanding against the side wall of the hollow organ in order to create a second, enhanced interference fit therewith.2. An implantable connector according to wherein the hollow expandable stent is constructed so that a change in the length of the internal skeleton results in a change in the diameter of the hollow expandable stent.314-. (canceled)15. An implantable connector according to wherein a change in the length of the internal skeleton results in a change in the diameter of the internal skeleton so as to cause a change in the diameter of the hollow expandable stent.16. An implantable connector according to wherein the hollow expandable stent is constructed so that (i) it has a generally cylindrical configuration when ...

METHODS FOR FLUID FLOW THROUGH BODY PASSAGES

A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage. 112-. (canceled)13. A method of diverting fluid flow from a first passage to a second passage , the method comprising: inserting a first catheter in the first passage upstream of an occlusion site;', 'inserting a second catheter in the second passage; and', 'deploying a needle from the first catheter through tissue between the first passage and the second passage, and into the second passage, wherein deploying the needle comprises guiding the needle using an ultrasound transmitter;, 'forming a third passage between the first passage and the second passage, wherein the first passage is an artery and the second passage is a vein and wherein the first passage is substantially parallel to the second passage, wherein forming the third passage comprises a first end portion having a first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being substantially cylindrical;', 'a second end portion having a second end diameter larger than the first end diameter, the second end portion having a second length along the longitudinal axis;', 'an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end ...

Methods and apparatus for percutaneous bypass graft

Methods and apparatus for a percutaneous bypass graft system according to various aspects of the present technology include a graft section comprising a dual-sided fixation system at the anastomosis site and a tamper sheath configured to provide enhanced control during installation. The dual-sided fixation system may comprise a plurality of barbs configured to secure the graft section to an internal and external portion of a target vessel. The tamper sheath comprises a cuff at a distal end that is configured to be positioned against an outer surface of the target vessel during the percutaneous procedure.

Surgical implant devices and methods for their manufacture and use

A method of implanting a device in a heart includes inserting an implant into a blood vessel with a delivery apparatus. The implant includes a stent member and an adjustment member. The stent member is circumferentially expandable and contractible. The adjustment member is coupled to the stent member. The delivery apparatus includes a rotatable shaft and a locking mechanism coupled to an end portion of the shaft. The shaft of the delivery apparatus is releasably coupled to the adjustment member of the implant by the locking mechanism of the delivery apparatus. The method further includes positioning the implant at an implantation location within a heart by manipulating the delivery apparatus, and rotating the shaft of the delivery apparatus relative to the stent member of the implant to actuate the adjustment member of the implant. Actuating the adjustment member results in circumferential expansion or contraction of the stent member.

ANCHOR DEVICE FOR VASCULAR ANASTOMOSIS

The present disclosure relates to a medical anchor device and methods of use for providing an improved device for intraluminally directed vascular anastomosis. The anchor device includes a generally tubular graft having a flange disposed at one end thereof, where a portion of the graft extends through the flange. The flange includes a wire frame made of a resilient material and a thin membrane covering or overlaying the wire frame, where the wire frame is self-expanding when deployed within a lumen. The device may be deployed within the lumen at an anastomotic site without a need for sutures, staples, clips, or other mechanical attachment means that may cause further injury. 1. A medical device for use in an anastomosis procedure in a body lumen of a patient , the device comprising:a generally tubular graft having a proximal portion and an opposite distal portion; anda self-expanding flange disposed adjacent the distal portion of the tubular graft, the flange including an opening in communication with the graft to form a fluid passageway through the flange, the flange further including a wire frame having a plurality of resilient arms radiating outwardly from a central portion of the wire frame, and a membrane overlaying the wire frame;wherein the self-expanding flange expands within the body lumen of the patient and is anchored against one or more lumen walls when the medical device is deployed at an anastomotic site.2. The medical device of claim 1 , wherein a portion of the tubular graft comprises a wire stent disposed between a first graft layer and a second graft layer to reinforce the tubular graft.3. The medical device of claim 2 , wherein the portion of the tubular graft comprising the wire stent is disposed adjacent the self-expanding flange.4. The medical device of claim 2 , wherein the portion of the tubular graft comprising the wire stent is disposed adjacent the self-expanding flange claim 2 , and wherein the flange claim 2 , once actuated claim 2 , has ...

ARTERIAL AND VENOUS ANCHOR DEVICES FORMING AN ANASTOMOTIC CONNECTOR AND SYSTEM FOR DELIVERY

An arterial anchor device and a venous anchor device operably coupled by graft material to form an anastomotic convector is provided. The arterial anchor device comprises a generally tubular main body including a distal end and a proximal end, the distal end defining a plurality of flanges integrally formed with the tubular main body and being movable from a first loaded position to a second expanded position. The venous anchor device includes a tubular main body having a metal frame structure and including a distal end and a proximal end, the distal end including a plurality of barbs thereon wherein said distal end has an outer diameter greater than the proximal end. The arterial anchor device and venous devices are fluidly connected by a graft to form an anastomotic connector. 1. An arterial anchor device for use in an anastomotic connector comprising:a generally tubular main body comprising a metal frame-like structure comprising a plurality of struts and connectors and including a distal end, a mid-portion, and a proximal end; anda plurality of flanges integrally formed with the main body at a distal end thereof, said flanges movable between a loaded position and an expanded position,wherein said distal end comprises a variable cutting pattern such that the struts and connectors at the distal end are closer together than the struts and connectors at the mid-portion and proximal end.2. The arterial anchor device of further comprising a graft material having a reinforced wall.3. The arterial anchor device of wherein the proximal end of said arterial anchor device has an outer diameter that is larger than or equal to an outer diameter at said distal end.4. The arterial anchor device of wherein said plurality of flanges are circumferentially disposed about the distal end.5. The arterial anchor device of wherein said flanges are configured to expand upon deployment to form an angle equal to or less than 90 degrees offset from a longitudinal axis of the tubular main ...

Bypass Configuration and Method of Construction

A method for constructing a vascular connector configured to bypass an occluded vessel which comprises a primary graft stem and a venous outflow stem. In general, the primary graft stem accepts a blood flow from an occluded vessel to bypass the occlusion. The venous outflow stem may extend from a wall of the primary graft stem and divert a portion of the blood flow to a native vein or other vessel of the vascular system. This configuration is beneficial in ensuring adequate blood flow at the vascular connector to inhibit the formation of clots and to extend the patency of the vascular connector. 1. A vascular connector comprising:a primary graft stem fabricated from a substantially hollow member, the primary graft stem having a first end and a second end to allow blood flow from a first blood vessel into the first end, through the primary graft stem and out the second end; anda venous outflow stem fabricated from a substantially hollow member, the venous outflow stem connected to and extending outward from an opening in the primary graft stem to create a fluid passage from the substantially hollow primary graft stem into the substantially hollow venous outflow stem which is capable of diverting a portion of the blood flow from the primary graft stem through the venous outflow step to a second blood vessel.2. The vascular connector of wherein an end of the primary graft stem is tapered.3. The vascular connector of wherein the venous outflow stem is integrally formed with the vascular bypass graft.4. The vascular connector of further comprising one or more ridges at one or both ends of the primary graft stem.5. The vascular connector of further comprising one or more angled ridges at an outflow end of the venous outflow stem.6. The vascular connector of wherein the vascular connector is lined with native vein claim 1 , allograft claim 1 , zenograft claim 1 , bioengineered or drug elution materials.7. The vascular connector of claim 1 , further comprising a synthetic ...

Vascular corrective appliance and supporting method for anastomosis part

A vascular corrective appliance and a supporting method for an anastomosis part capable of reducing or preventing narrowing at an anastomosis part between vessels and/or narrowing in the vicinity of the anastomosis part wherein the vascular corrective appliance and the supporting method are configured to support a first vessel and a second vessel from their outer sides in such a manner that an angle formed between a blood flow direction of the first vessel and a blood flow direction of the second vessel at an anastomosis part where the first vessel is anastomosed in a branch pattern with the second vessel becomes an acute angle, and that the first vessel is curved on a downstream side from the anastomosis part to extend toward an upstream side of the second vessel from the anastomosis part.

Devices, systems, and methods for prosthesis delivery and implantation, including the use of a fastener tool

Devices, systems, and methods for implanting radially expandable prostheses in the body lumens rely on tacking or anchoring the prostheses with separately introduced fasteners. The prostheses may be self-expanding or balloon expandable, and may include a single lumen or more than one lumen. After initial placement, a fastener applier system is introduced within the expanded prostheses to deploy a plurality of fasteners to at least one prosthesis end. The fasteners are usually helical fasteners which are releasably restrained on the fastener driver, and are delivered by rotation of the fastener driver. The fasteners may be applied singly, typically in circumferentially spaced-apart patterns about the interior of at least one end of the prosthesis. A lumen extension or lumens may be coupled to the prosthesis to extend the reach of the prosthesis within the implantation site. Fasteners may also be applied to the lumen extensions.

COMPOSITE VALVED GRAFT COMPRISING DOUBLE SEWING CUFFS

Disclosed is an artificial valved conduit that is a composite valved graft comprising double sewing cuffs, which can be easily used in aortic root replacement. The composite valved graft comprises a valve and a conduit part connected to the valve. The conduit part comprises a sewing cuff positioned on the outer circumference thereof. The sewing cuff comprises a first sewing cuff and a second sewing cuff positioned below the first sewing cuff. Accordingly, a double suture is easily performed, so that it is possible to prevent the loss of blood after a surgery and to reduce surgical time at the same time. 1. A composite valved graft , comprising:a valve; anda conduit part connected to the valve,wherein the conduit part comprises a sewing cuff positioned on the outer circumference thereof, and the sewing cuff comprises a first sewing cuff and a second sewing cuff positioned below the first sewing cuff.2. The composite valved graft of claim 1 , wherein the valve comprises a valve part having a valve leaflet and a valve leaflet support claim 1 , and a hollow opening positioned around the outside of the valve part to accommodate the valve part therein claim 1 , andwherein the valve leaflet support is connected to the inner surface of the opening to support the valve leaflet.3. The composite valved graft of any one of and claim 1 , wherein each of the first and second sewing cuffs has a continuous ring shape.4. The composite valved graft of claim 3 , wherein the first and second sewing cuffs are positioned parallel to each other while being spaced apart.5. The composite valved graft of claim 3 , wherein the first and second sewing cuffs extend from the same position on the outer circumference of the conduit part. 1. Field of the InventionThe present invention relates to a composite valved graft, and more particularly, to an artificial valved conduit that is a composite valved graft comprising double sewing cuffs, which can be easily used in aortic root replacement.2. ...

LONGITUDINALLY AND RADIALLY FLEXIBLE ANASTOMOSIS STENT

An anastomosis stent includes an elongated body of a tubular configuration having a length and diameter dimensions extending in axial and radial directions of the elongated body and in a transverse relationship to each other. The elongated body is formed by multiple rings stacked adjacent one another in a direction parallel to the length dimension. Each ring is a single strand of wire bent in a repetitive pattern of sine waves. Each sine wave defines an alternating peak and valley divided by a length dimension extending orthogonal to the length dimension of the elongated body. The rings are fused together at locations on selected pairs of adjacent peaks and valleys of the rings with the fused locations arranged in parallel rows. The elongated body includes main and end portion and a safety mark about the elongated body at the juncture therebetween. 1. An anastomosis stent , comprising:an elongated body of a tubular configuration and having a length dimension extending in an axial direction of said elongated body and a diameter dimension extending in a radial direction of said elongated body being in a transverse relationship to said axial direction of said elongated body;said elongated body being formed by a multiplicity of rings stacked adjacent to one another in a direction parallel to said length dimension of said elongated body, each of said rings being formed by a single strand of wire bent in a repetitive pattern of sine waves;each of said sine waves defining an alternating peak and valley divided by a length dimension extending orthogonal to said length dimension of said elongated body; andsaid multiplicity of rings being fused to one another at locations on selected pairs of adjacent peaks and valleys of said sine waves in said single strand of wire of each of said rings so as to provide flexibility of said rings in said radial direction relative to said axial direction of said elongated body.2. The anastomosis stent of wherein said single wire of each of ...

STENTED VASCULAR GRAFT

A vascular graft incorporating a stent into a portion of its length. While various materials may be used for the vascular graft, the graft is preferably an ePTFE graft. The stent is preferably a self-expanding stent, although it may alternatively be a balloon expandable stent. The vascular graft preferably has a continuous inner tubular liner that extends between the opposing ends of the graft and provides a continuous luminal surface for blood contact that is uninterrupted by seams or joints. The length portion of the graft that does not include the stent has a greater wall thickness than does the portion including the stent. 119-. (canceled)20. An implantable device configured to be delivered into a body conduit of a patient , the implantable device comprising:a tubular vascular graft that has a length, an inside diameter, a first end, and a second end, the length including a first length portion and a second length portion that together make up the entire length of the implantable device;a stent coupled to the first length portion of the tubular vascular graft, the stent having a first end positioned toward the first end of the tubular vascular graft, a second end, and a length, the length of the stent being coextensive with the first length portion of the tubular vascular graft; anda sheath maintaining the stent at a compacted, delivery profile, the sheath being progressively releasable in a direction extending from the first end toward the second end of the stent.21. The implantable device of claim 20 , wherein the sheath is configured to be progressively splittable in the direction extending from the first end toward the second end of the stent.22. The implantable device of claim 21 , wherein the stent is self-expanding and progressive splitting of the sheath progressively releases the stent claim 21 , allowing stent to deploy beginning with the first end and progressing to the second end.23. The implantable device of claim 20 , wherein the second length ...

IMPLANT FOR SUPPORTING BODILY CONDUITS SUCH AS BLOOD VESSELS OR/AND GRAFTED VESSELS

Implant for supporting bodily conduits, such as blood vessels or/and grafted vessels, inside a subject. In exemplary embodiments, the implant includes a support fixedly displaceable and plastically stretchable to points along longitudinal axis of the support, when subjected to a stretching force, thereby forming a new shape, the support substantially maintains the new shape upon removal of the stretching force. The support, when forming the new shape, is plastically reversely compressible in a direction along the support longitudinal axis, when subjected to axially compressive force. Support may include a radially elastic portion configured to regain fixedly deformed diameter upon removal of radially compressive force applied thereto. Support is configurable as an intraluminal support for intraluminal deployment and setting in a conduit segment, or, as an external support for enveloping a conduit segment, so as to change route or/and shape of the conduit segment. 1. An implant for supporting a conduit inside a body of a person or an animal , the implant comprising: a support that is fixedly displaceable and plastically stretchable to a plurality of points along a longitudinal axis of the support , when subjected to a stretching force , thereby forming a new shape , said support substantially maintains said new shape upon removal of said stretching force.2. The implant of claim 1 , wherein said support claim 1 , when forming said new shape claim 1 , is plastically reversely compressible in a direction along said longitudinal axis claim 1 , when subjected to an axially compressive force.3. The implant of claim 1 , wherein said support is configured for supporting the conduit being a blood vessel or/and a grafted vessel.4. The implant of claim 1 , wherein said support is configured for supporting the conduit being a body vessel with a varying cross sectional diameter claim 1 , wherein the support is fixedly deformable in diameter along a plurality of points of said ...

INTRAVASCULAR DEVICE FOR HEMIARCH REPAIR AND ASSOCIATED METHOD

Vascular devices and methods for addressing pathologies in the hemiarch of the aorta are provided. The device includes a main body () and a secondary body (). The main body has ends () that are designed to be connected to corresponding ends of the native blood vessel. The secondary body has a free end () and a fixed end () that is engaged with an inner surface of the main body. The vascular device is movable from a retracted configuration, in which the secondary body is at least partially contained within the main body and the free end is on a proximal side of the fixed end, to an extended configuration, in which the secondary body is extended distally from the main body and the free end is on a distal side of the fixed end to address defects in the aorta downstream of the hemiarch. 1. A vascular device configured for replacing at least part of a patient's hemiarch , the vascular device comprising:a main body having a first end and a second end, wherein each of the first and second ends is configured to be attached to a corresponding end of a native blood vessel to provide a pathway for blood flow from the patient's heart to vasculature distal to the heart;a secondary body having a free end and a fixed end, wherein the fixed end is engaged with an inner surface of the main body to limit movement of the fixed end in an axial direction; andwherein the vascular device is configured to be moved from a retracted configuration, in which the secondary body is at least partially contained within the main body and the free end is on a proximal side of the fixed end, to an extended configuration, in which the secondary body is extended distally from the main body and the free end is on a distal side of the fixed end, andwherein, in the extended configuration, the secondary body is configured to engage downstream portions of the patient's aorta with respect to a position of the main body.2. The vascular device of claim 1 , wherein the secondary body defines an opening through ...

Vascular graft securement apparatuses and related kits and methods

Some of the present apparatuses include a flexible vascular graft defining a lumen and a hub having a distal end configured to penetrate a blood vessel, a proximal end, and a wall extending between the distal end and the proximal end that defines an interior passageway. In some apparatuses, the vascular graft is non-removably coupled to the hub, and the lumen of the vascular graft is in communication with the interior passageway of the hub. Some apparatuses include one or more helical protrusions fixed in relation to the wall and configured to secure the hub relative to the blood vessel, each of the one or more helical protrusions extending away from the interior passageway. In some apparatuses, the wall has an outer surface defining an annular recess that extends around the wall, the recess configured to receive at least a portion of a wall of the blood vessel.

COMPOSITIONS AND METHODS FOR REMOVING BIO-SYNTHETIC NANO-PARTICLES FROM BODILY FLUIDS

Bait and capture methods and compositions for removing bio-synthetic nano-particles from body fluids. Bio-synthetic nano-particles are baited with one-half of a bait and capture complex and lyophilized. The baited bio-synthetic nano-particle is reconstituted and administered to a subject for diagnostic or therapeutic purposes. To remove the bio-synthetic nano-particle from the body, the body fluid containing the baited bio-synthetic nano-article is contacted with the capture portion of the bait and capture complex. The body fluid from which the bio-synthetic nano-particles have been removed may be returned to the subject. 2. A composition comprising the compound of and a bio-synthetic nano-particle , wherein adamantane functional groups of the compound of are located on a surface of the bio-synthetic nano-particle.3. A composition according to claim 1 , wherein the bio-synthetic nano-particle is a bio-synthetic nano-cyte blood substitute.4. A lyophilized composition comprising the compound of and a bio-synthetic nano-particle claim 1 , wherein functional groups of the compound of are located on a surface of the bio-synthetic nano-particle blood substitute.5. A lyophilized composition according to claim 4 , wherein the bio-synthetic nano-particle is a bio-synthetic nano-cyte blood substitute.6. (canceled)7. A method for removing a bio-synthetic nano-particle from a bodily fluid comprising complexing a compound of to a bio-synthetic nano-particle claim 4 , administering to a subject the bio-synthetic nano-particle complexed to the compound of claim 4 , and subsequently contacting the bodily fluid with mono-6-O-(p-toluenesulfonyl)-β-cyclodextrin functionalized polystyrene beads claim 4 , to remove said bio-synthetic nano-particle complexed to the compound of from said bodily fluid.8. A method according to wherein the bio-synthetic nano-particle is a bio-synthetic nano-cyte blood substitute and the bodily fluid is whole blood.9. A method according to claim 7 , further ...

Graft Devices and Methods of Fabrication

A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft device between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion. 1. A graft device comprising:a flow conduit comprising an inner surface, an outer surface, a proximal end, a distal end, and a lumen therethrough; anda covering having a thickness and at least one channel extending from at least one of the inner surface or the outer surface of the flow conduit, the at least one channel extending through at least a portion of the thickness of the coveringwherein the graft device is constructed to provide connection between a first body space and a second body space.2. The device of wherein the covering further comprises an inner surface and an outer surface claim 1 , wherein the at least one channel extends from the inner surface to the outer surface of the covering.3. The device of wherein the at least one channel has a diameter of approximately 100 microns to 200 microns.4. The device of wherein the at least one channel has a length of approximately 100 microns to 1000 microns.5. The device of wherein the at least one channel is configured and arranged to induce angiogenesis.6. The device of wherein the at least one channel comprises a circuitous route.7. The device of wherein the at least one channel comprises a relatively linear route.8. The device of wherein the relatively linear route is laser cut.9. The device of wherein the at least one channel is constructed and arranged to approximate one or more properties of the vasa vasorem of a vessel.10. The device of wherein ...

PERCUTANEOUS POTTS SHUNT DEVICES AND RELATED METHODS

The disclosure provides various embodiments of prostheses and delivery systems to permit an interventional cardiologist to create shunts between various blood vessels. Moreover, the disclosed shunts can be used to shunt between various hollow organs, as set forth in the present disclosure. 1. A method of delivering a tubular prosthesis in a Potts procedure , comprising:providing a prosthesis on a percutaneous delivery catheter including:an elongate compliant tubular body having a proximal end and a distal end;a distal sealing flange coupled to the distal end of the elongate compliant tubular body, the distal sealing flange being configured and arranged to facilitate seating the tubular prosthesis against a first concave vessel wall of a first vessel, wherein the tubular prosthesis is configured to extend outwardly through a first ostium formed in the first concave vessel wall when deployed, wherein the distal sealing flange remains inside the ostium after deployment;a proximal sealing flange coupled to the proximal end of the elongate compliant tubular body, the proximal sealing flange being configured and arranged to facilitate seating the tubular prosthesis against a second concave vessel wall of a second vessel, wherein the tubular prosthesis is configured to extend outwardly through a second ostium formed in the second concave vessel wall when deployed, wherein the distal sealing flange remains inside the second ostium after deployment;introducing the prosthesis on the percutaneous delivery catheter into a patient's vasculature;forming an ostium into a wall of the patient's left pulmonary artery and an ostium into a wall of the patient's descending aorta;deploying a first of the proximal sealing flange and distal sealing flange into the ostium formed into the wall of the left pulmonary artery; anddeploying the other of the proximal sealing flange and distal sealing flange into the ostium formed into the wall of the patient's descending aorta.2. The method of ...

STENT TO ASSIST IN ARTERIOVENOUS FISTULA FORMATION

There is described an arteriovenous fistula stent, having a tubular body comprising a series of sinusoidal shaped struts along the length of the tubular body. A plurality of curvilinear connectors extend between and are attached to adjacent struts wherein a first end of a connector is attached to a distal face of a proximal strut apex and a second end of a connector is attached to a proximal face of a distal strut apex. A pair of unconnected strut apexes are between pairs of connected apexes. When the tubular body is in a stowed configuration a proximal aperture and a distal aperture are circular and when the tubular body is in a deployed configuration the distal aperture is oblong or ovoid. There is also described a method for inserting a stent for use in creation of an arteriovenous fistula by identifying a candidate artery and a candidate vein and dissecting the candidate vein. Next, inserting a stent into the vein and creating a breach in the candidate artery at a desired angle and location. Next, introducing the stent and vein into the candidate artery and forming the stent into a curvature angle selected to minimize turbulent blood flow in an anastomosis formed by the vein and the artery. Optionally, there is a step of fastening a distal portion of the stent to the artery. 113.-. (canceled)14. A method for inserting a stent for use in creation of an arteriovenous fistula , comprising the steps of:identifying a candidate artery and a candidate vein;dissecting the candidate vein;inserting a stent into the vein;creating a breach in the candidate artery at a desired angle and location;introducing the stent and vein into the candidate artery;forming the stent into a curvature angle selected to minimize turbulent blood flow in an anastomosis formed by the vein and the artery; andfastening a distal portion of the stent to the artery to form an anastomosis.15. The method of wherein after the fastening step the anastomosis formed by the vein and the artery forms an ...

METHODS AND DEVICES FOR MINIMALLY INVASIVE TRANSCATHETER CORONARY ARTERY BYPASS GRAFTING

Systems and methods for performing transcatheter coronary artery bypass grafting procedures are provided. The methods generally involve passing the graft from the aorta to the coronary artery through the pericardial space. The systems include poke-out wires, a coring device, and devices for 1. A device for entering a wall of a blood vessel comprising:a first sheath having a proximal end, a distal end, and a hinge along its length with an aperture at the hinge;a cap coupled to the distal end of the first sheath;a tether filament coupled to the cap and extending proximally along the first sheath external to the first sheath;a wire slidable within the first sheath and configured to extend through the aperture toward the wall of the blood vessel.2. The device of claim 1 , wherein the hinge of the first sheath is configured to extend radially away from the tether with a proximal translation of the tether filament claim 1 , and wherein the hinge of the first sheath extends radially towards the tether with a distal translation of the tether filament.3. The device of claim 1 , further comprising a second sheath having a proximal end claim 1 , a distal end claim 1 , and a hinge along its length with an aperture at the hinge claim 1 , and wherein the distal end of the second sheath is coupled to the cap.4. The device of claim 3 , wherein the tether filament is disposed between the first sheath and the second sheath.5. The device of claim 3 , wherein the wire is slidable within the second sheath.6. The device of claim 3 , wherein a second wire is slidable within the second sheath.7. The device of claim 1 , further comprising a handle coupled to the tether filament claim 1 , the handle comprising an actuator configured to proximally and distally translate the tether filament.8. A device for entering a wall of a blood vessel comprising:a catheter;a tether filament extending through the catheter;a cap coupled to a distal end of the tether filament;a plurality of sheaths arranged ...

APPARATUS AND METHOD FOR CONNECTING A CONDUIT TO A HOLLOW ORGAN

An apparatus and method for connecting a first conduit to the heart without cardiopulmonary bypass. The first conduit may be attached to a second conduit having a prosthetic device interposed. The second conduit may then be connected to the aorta. The prosthetic device may be a prosthetic valve (or pump). The apparatus includes an implantable connector with first conduit component, a coring component, a retractor expansion component slidably coupled to the coring component, and a pushing component. The retractor expansion component seats against and separates the inside wall of the left ventricle so that the coring component cuts cleanly through the myocardium, forming a tissue plug. By remaining seated against the inside wall, the retractor expansion component follows the tissue plug into the coring component. The surgeon applies force and rotary motion to the pushing component sufficient to cut the tissue plug and implant the prosthetic component. 196-. (canceled)97. A method for using an applicator to form a hole in a wall of a hollow organ and insert a connector conduit into the hole , said applicator comprising a hole forming element having a cutting element on a distal end thereof and being coupled to the connector conduit with a distal end of said connector conduit being adjacent said cutting element , a retractor element having an expansion element , and sequencing means for coordinating the relative movement of said retractor element with respect to said hole forming element , said method comprising:a) inserting a distal end of the retractor element through a slit formed in the wall of the organ while the retractor element is locked in a fully extended position relative to the hole forming element and the expansion element is in an unexpanded stateb) expanding the expansion element to a fully expanded state and moving the expansion element toward the hole forming element;c) forming the whole with the cutting element and inserting the connector conduit into ...

VASCULAR PROSTHESIS FOR USE IN THE TREATMENT OF ARTERIAL DISEASES

Disclosed is a vascular prosthesis made of biocompatible material including at least one first portion that is tubular and resilient at least in longitudinal sense. At least the tubular and resilient first portion has at least one reinforcement frame of biocompatible material shaped like a cuff-like covering, the reinforcement frame being adapted to allow the execution of at least one suture line with separated stitches for the stable and durable anchoring of the prosthesis to the vascular core of interest, the reinforcement frame defining, with the prosthesis portion from which it departs, an interspace, the latter being delimited by the external surface of the prosthesis portion enclosed by the reinforcement frame and by the internal surface of the latter. 1111221100272210021. A vascular prosthesis () made of biocompatible material comprising at least one first portion (′) that is tubular and resilient at least in longitudinal sense , wherein at least said tubular and resilient first portion (′) has at least one reinforcement frame () shaped like a cuff-like covering , said reinforcement frame () being adapted to allow the execution of at least one suture line with separated stitches for the stable and durable anchoring of said prosthesis () to the vascular core () of interest , said reinforcement frame () defining , with the prosthesis portion from which the reinforcement frame departs , an interspace () , the latter being delimited by the external surface of the prosthesis portion enclosed by said reinforcement frame () and by the internal surface of the latter , said reinforcement frame () having a first base and a second base , said first base being that closest , with respect to said second base , to the vascular core () end to which said frame () is to be sutured and to the tubular portion of the prosthesis ′ with which the frame is in a continuity relationship.2122. The vascular prosthesis () according to claim 1 , wherein the reinforcement frame () has a ...

APPARATUS AND METHOD OF PLACEMENT OF A GRAFT OR GRAFT SYSTEM

An endoluminal prosthesis system deployable in a region of a patient's vasculature having one or more branch vessels, having a main graft body having a first opening in a wall portion of the main graft body and a pre-loaded guidewire positioned inside the main graft body and advanced through the first opening. One or more branch grafts can be attached to the main graft body to cover one or more openings in the main graft body. 1. An endoluminal prosthesis system , comprising:a delivery catheter having a flexible catheter body, a proximal end, and a distal end; a first main graft body having a first lumen extending axially therethrough;', 'a first lateral opening extending through a wall portion of the first main graft body, the first lateral opening defining a first dimension;', 'a second lateral opening extending through the wall portion of the first main graft body, the second lateral opening positioned opposite the first lateral opening and defining a second dimension;, 'an endoluminal prosthesis comprisinga first hollow guidewire extending from the proximal end of the flexible catheter body through at least a portion of the flexible catheter body, through at least a portion of the first lumen of the first main graft body, and through the first lateral opening in the wall portion of the first main graft body when the first main graft body is in a collapsed, pre-delivery state within the flexible catheter body; anda second hollow guidewire extending from the proximal end of the flexible catheter body through at least a portion of the flexible catheter body, through at least a portion of the first lumen of the first main graft body, and through the second lateral opening in the wall portion of the first main graft body when the first main graft body is in the collapsed, pre-delivery state within the flexible catheter body.2. The endoluminal prosthesis system of claim 1 , wherein the second dimension is approximately four times larger than the first dimension.3. The ...

SYNERGISTIC DIETARY SUPPLEMENT COMPOSITIONS FOR ENHANCING PHYSICAL PERFORMANCE AND ENERGY LEVELS

The present invention discloses novel synergistic dietary supplement compositions comprising at least two ingredients selected from the extracts and fractions derived from and as natural energy enhancer for enhancing physical performance, muscle strength, muscle mass, mental alertness and energy levels in a mammal. 1Cinnamomum tamalaGarcinia mangostana. A composition comprising a mixture of from 20% to 80% of an extract of and from 20% to 80% of an extract of , based on the weight of the composition.2Sphaeranthus indicus, Curcuma longa, Cissus quadrangularis, Coleus aromaticus, Citrullus lanatus, Ocimum sanctum.. The composition according to claim 1 , which further comprises at least one extract selected from the group consisting of extracts of3Ocimum basilicum, Zingiber officinalis, Tribulus terrestris, Trachyspermum ammi, Mentha arvensis, Piper cubebaFoeniculum vulgare.. The composition according to claim 1 , which further comprises at least one biologically active extract selected from the group consisting of extracts of and4Ocimum basilicum, Zingiber officinalis, Tribulus terrestris, Trachyspermum ammi, Mentha arvensis, Piper cubebaFoeniculum vulgare.. The composition according to claim 2 , which further comprises at least one biologically active extract selected from the group consisting of extracts of and5Cinnamomum tamalaGarcinia mangostana. The composition according to claim 1 , comprising a mixture of the extract of and the extract of in a 2:1 ratio.6. The composition according to claim 1 , further comprising at least one ingredient selected from the group consisting of excipients claim 1 , diluents claim 1 , sweeteners claim 1 , flavorants colorants claim 1 , vitamins and amino acids.7. The composition according to claim 2 , further comprising at least one ingredient selected from the group consisting of excipients claim 2 , diluents claim 2 , sweeteners claim 2 , flavorants colorants claim 2 , vitamins and amino acids.8. The composition according to claim ...

Magnetically Activated Arteriovenous Access Valve System and Related Methods

In one aspect, an arteriovenous access valve system may generally include a first valve configured to be positioned at or adjacent to an end of an arteriovenous graft and a second valve configured to be positioned at or adjacent to an opposite end of the arteriovenous graft. In addition, the system may include an actuator assembly in fluid communication with the first and second valves. The actuator assembly may include a housing, a driver assembly positioned within the housing and a drive magnet positioned within the housing. The drive magnet may be rotatably coupled to the driver assembly such that, when the drive magnet is rotated, the driver assembly is configured to be rotatably driven so as to supply fluid to the first and second valves or to draw fluid out of the first and second valves depending on a rotational direction of the driver assembly. 120-. (canceled)21. An arteriovenous access valve system , comprising:a first valve configured to be positioned at or adjacent to a first end of an arteriovenous graft, the first valve movable between a closed position and an opened position;a second valve configured to be positioned at or adjacent to an opposite second end of the arteriovenous graft, the second valve movable between a closed position and an opened position; andan actuator assembly in fluid communication with the first and second valves via first and second flow paths, respectively, the actuator assembly configured to supply fluid through the first and second flow paths to actuate the first and second valves from the opened position to the closed position;wherein, when the actuator assembly is supplying fluid through both the first flow path and the second flow path, a flow restriction for the fluid flowing to the first and second valves differs between the first and second flow paths such that the first valve is moved to the closed position prior to the second valve.22. The arteriovenous access valve system of claim 21 , wherein the first end of the ...

Power system for and method of operation of magnetically-activated arteriovenous access valve system

A power system for and method of operation of an arteriovenous access valve system including two valves positioned near arteriovenous grafts, an actuator assembly in fluid communication with the valves and including a driver assembly, at least one pressure sensor, a separate activator device for driving the driver assembly, and a sensor communications device communicatively coupled to the at least one pressure sensor for wirelessly transmitting pressure measurements. The power system and method also include using an initiator device located in the activator device to power remotely the sensor communications device, for example via near field communication such as via a radio frequency field.

VASCULAR GRAFT SECUREMENT APPARATUSES AND RELATED KITS AND METHODS

Some of the present apparatuses include a flexible vascular graft defining a lumen and a hub having a distal end con figured to penetrate a blood vessel, a proximal end, and a wall extending between the distal end and the proximal end that defines an interior passageway. In some apparatuses, the vascular graft is non-removably coupled to the hub, and the lumen of the vascular graft is in communication with the interior passageway of the hub. Some apparatuses include one or more helical protrusions fixed in relation to the wall and configured to secure the hub relative to the blood vessel, each of the one or more helical protrusions extending away from the interior passageway. In some apparatuses, the wall has an outer surface defining an annular recess that extends around the wall, the recess configured to receive at least a portion of a wall of the blood vessel. 1. An apparatus for securing a vascular graft to a blood vessel , the apparatus comprising:a flexible vascular graft defining a lumen; and a distal end configured to penetrate a blood vessel;', 'a proximal end;', 'a wall extending between the distal end and the proximal end that defines an interior passageway; and', 'one or more helical protrusions fixed in relation to the wall and configured to secure the hub relative to the blood vessel, each of the one or more helical protrusions extending away from the interior passageway;, 'a hub havingwhere the vascular graft is non-removably coupled to the hub, and the lumen of the vascular graft is in communication with the interior passageway of the hub.2. The apparatus of claim 1 , comprising:a penetrator configured to penetrate the blood vessel;where the penetrator is disposable through the lumen of the vascular graft and through the interior passageway of the hub.3. The apparatus of claim 2 , where the penetrator defines an interior passageway sized for a guide wire.4. An apparatus for securing a vascular graft to a blood vessel claim 2 , the apparatus ...

DEVICE FOR ANASTOMOTIC BYPASS

A stent including a tubular body formed of one or more interwoven wires, a first anchor member disposed adjacent the first open end of the stent, a second anchor member disposed adjacent the second open end of the stent, and at least one divider disposed between the first and second anchor members. The first and second anchor members and the divider extend radially outward from the tubular body to divide the tubular body into at least a first saddle region extending between the first anchor member and the divider and a second saddle region extending between the second anchor member and the divider. 1. A stent comprising:a tubular body formed of one or more interwoven wires, the tubular body having first and second opposing open ends and a lumen extending therebetween, the tubular body defining a longitudinal axis and a length extending between the first and second open ends;a first anchor member disposed adjacent the first open end and a second anchor member disposed adjacent the second open end, the first and second anchor members each extending radially outward from the tubular body, the first and second anchor members each having an outer diameter larger than an outer diameter of the tubular body disposed between the first and second anchor members; andat least one divider disposed between the first and second anchor members, the at least one divider extending radially outward from the tubular body and having an outer diameter larger than the outer diameter of the tubular body, the at least one divider dividing the tubular body into at least a first saddle region extending between the first anchor member and the at least one divider and a second saddle region extending between the second anchor member and the at least one divider.2. The stent of claim 1 , wherein the first and second anchor members are interwoven with the tubular body.3. The stent of claim 1 , wherein the first and second anchor members are less flexible than the tubular body.4. The stent of ...

DEVICE FOR RAPID REPAIR OF BODY CONDUITS

A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel. 1. An implantable tubular prosthesis having first and second opposing ends and a lumen extending between the ends wherein said first end , and a lumen and an outer surface extending between the ends , the implantable tubular prosthesis including a vascular graft having a first end and a second end and a stent located at the first end of the vascular graft , a length of the vascular graft extending beyond one end of the stent to the second end of the implantable tubular prosthesis ,wherein the stent is coaxially received with the vascular graft, the stent having a smaller compacted diameter for insertion into a body conduit and a larger expanded diameter for contacting inner surfaces of the body conduit,wherein the compacted stent is contained in a releasable delivery sheath, the delivery sheath having a first end adjacent the first end of the implantable tubular prosthesis and a ...

ANTI-MIGRATION MICROPATTERNED STENT COATING

An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided. 1. An endoprosthesis having an expanded state and an unexpanded state , the endoprosthesis comprising:a stent, wherein the stent has a first end, a second end, an inner surface extending from the first end to the second end and defining a lumen, an outer surface extending from the first end to the second end, and a thickness defined between the inner surface and the outer surface; and 'a polymeric coating comprising a base and a plurality of protrusions, the base comprising a first major surface facing the outer surface of the stent, the base further comprising a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern.', 'a stent end covering disposed at one of the first and second ends, the stent end covering comprising2. The endoprosthesis of claim 1 , wherein the stent end covering is adhered to the outer surface of the stent.3. The endoprosthesis of claim 1 , wherein the stent end covering is adhered to the inner surface of the stent.4. The endoprosthesis of claim 1 , wherein the stent end covering extends ...

METHODS AND DEVICES FOR PERCUTANEOUS IMPLANTATION OF ARTERIO-VENOUS GRAFTS

Methods, devices, and kits for implanting a vascular graft to perform hemodialysis treatments on patients with renal failure are disclosed. The kits can include access devices comprised of an access catheter having a guidewire lumen and stylet lumen, a guide tube having a curved distal end, a stylet, an actuator handle and a vascular graft. The methods describe techniques for using the described kits and devices for performing vascular procedures, such as percutaneous implantation of the vascular graft. 1. A method of percutaneously implanting an arterio-venous graft , comprising:advancing a first guidewire into a lumen of a first artery from a second artery;advancing a second guidewire into a lumen of a first vein from a second vein;advancing a first access catheter over the first guidewire into the lumen of the first artery;advancing a second access catheter over the second guidewire into the lumen of the first vein;operating a first guide tube actuator to advance a first guide tube from the first access catheter toward a portion of a wall of the first artery;operating a second guide tube actuator to advance a second guide tube from the second access catheter toward a portion of a wall of the first vein;operating a first stylet actuator to advance a first stylet along a curved path through the first guide tube and through the wall of the first artery to form an arterial exit site; andoperating a second stylet actuator to advance a second stylet along a curved path through the second guide tube and through the wall of the first vein to form a venous exit site.2. The method of claim 1 , further comprising forming a subcutaneous tunnel between the arterial exit site and the venous exit site.3. The method of claim 2 , further comprising:advancing a guide catheter over the second stylet;wherein the guide catheter passes through the venous exit site and through the subcutaneous tunnel; andwherein a distal end of the guide catheter is disposed adjacent the arterial exit ...

ANCHOR DEVICE FOR VASCULAR ANASTOMOSIS

The present disclosure relates to a medical anchor device and methods of use for providing an improved device for intraluminally directed vascular anastomosis. The anchor device includes a generally tubular graft having a flange disposed at one end thereof, where a portion of the graft extends through the flange. The flange includes a wire frame made of a resilient material and a thin membrane covering or overlaying the wire frame, where the wire frame is self-expanding when deployed within a lumen. The device may be deployed within the lumen at an anastomotic site without a need for sutures, staples, clips, or other mechanical attachment means that may cause further injury. 1. A method for positioning a medical anchor device at an anastomotic site in a body lumen of a patient , the method comprising:advancing a delivery sheath to the anastomotic site within the body lumen of the patient; a generally tubular graft having a proximal portion and an opposite distal portion; and', 'a first self-expanding flange disposed adjacent the distal portion of the tubular graft, the first self-expanding flange including an opening in communication with the graft to form a fluid passageway through the first self-expanding flange, the first self-expanding flange further including a wire frame having a plurality of resilient arms radiating outwardly from a central portion of the wire frame, and a membrane overlaying the wire frame; wherein upon displacement of the first self-expanding flange into the lumen of the delivery sheath the plurality of resilient arms collapse toward each other;, 'disposing the medical anchor device within a lumen of the delivery sheath, the medical anchor device comprisingadvancing the medical anchor device through the delivery sheath toward the anastomotic site, wherein upon displacement of the first self-expanding flange out of the lumen of the delivery sheath and into the body lumen of the patient, the plurality of resilient arms are displaced away from ...

Encapsulated or coated stent systems

A stent system comprising zero or more inner stents inserted into an outer stem. The inner stems and outer stent are separated and/or encapulated by a protein-based material of a protein matrix and/or a set biocoacervate, each comprising one or more biocompatible proteins and one or more biocompatible solvents. The protein-based material may also include one or more carbohydrates and one or more pharmacologically active agents.

VENOUS ANCHOR DEVICES FORMING AN ANASTOMOTIC CONNECTOR

A venous anchor device operably coupled by graft material to form an anastomotic connector is provided. The venous anchor device includes a tubular main body having a metal frame structure and including a distal end and a proximal end, the distal end including a plurality of barbs thereon wherein said distal end has an outer diameter greater than the proximal end. The venous anchor device is fluidly connected by a graft to form an anastomotic connector. 1. A venous anchor device comprising:a tubular main body comprising a metal frame structure defined by a plurality of struts and connectors, said tubular main body including a distal end and a proximal end, said distal end including a plurality of barbs thereon wherein said distal end has an outer diameter greater than the proximal end.2. The venous anchor device of wherein said barbs extend radially outwardly at an acute angle from a longitudinal axis of the tubular main body.3. The venous anchor device of wherein said barbs are configured to lie adjacent a venous vessel wall.4. The venous anchor device of wherein said barbs are configured to penetrate a venous vessel wall to seat said device in a venous passageway.5. The venous anchor device of wherein said venous anchor device is coated with a fluid impermeable material.6. The venous anchor device of wherein said venous anchor device is formed from a shape memory material.7. The venous anchor device of wherein said fluid impermeable material is woven.8. The venous anchor device of wherein said fluid impermeable material is a polymeric material.9. The venous anchor device of wherein said fluid impermeable material is deposited onto said device by electrospinning.10. The venous anchor device of wherein said fluid impermeable material is deposited onto said device by extrusion.11. The venous anchor device of wherein said coating covers the entirety of said device.12. The venous anchor device of wherein said coating covers the proximal end claim 5 , a mid-portion and ...

Arterial anchor devices forming an anastomotic connector

An arterial anchor device operably coupled by graft material to form an anastomotic connector is provided. The arterial anchor device comprises a generally tubular main body including a distal end and a proximal end, the distal end defining a plurality of flanges integrally formed with the tubular main body and being movable from a first loaded position to a second expanded position. The arterial anchor device is fluidly connected by a graft to form an anastomotic connector.

HYBRID PROSTHESIS AND DELIVERY SYSTEM

A hybrid endoprosthetic device comprises a stented tubular part and a branched tubular body connected such that a main lumen of the stented tubular part communicates with a main lumen of the branched tubular body. The branched tubular body has multiple branch lumens for connection with natural vessels of the vasculature, and includes at least one branch lumen for access to facilitate delivery and implantation of the hybrid endoprosthetic device by an endovascular step in a hybrid surgical procedure. The hybrid endoprosthetic device is configured to replace a part of the aorta and common iliac artery. A delivery system for use with the device is also disclosed. 1. A hybrid endoprosthetic device comprising a stented tubular part and a branched tubular body connected such that a main lumen of the stented tubular part communicates with a main lumen of the branched tubular body , wherein the branched tubular body has multiple branch lumens for connection with natural vessels of the vasculature , and includes at least one branch lumen for access to facilitate delivery and implantation of the hybrid endoprosthetic device by an endovascular step in a hybrid surgical procedure , and the hybrid endoprosthetic device is configured to replace a part of the aorta and common iliac artery.2. The hybrid endoprosthetic device claimed in claim 1 , wherein the multiple branch lumens of the branched tubular body comprise multiple tubular branches extending laterally from the branched tubular body with respect to a longitudinal axis through the main lumen of the branched tubular body.3. The hybrid endoprosthetic device claimed in claim 1 , wherein the branched tubular body comprises a bifurcated part.4. The hybrid endoprosthetic device claimed in claim 3 , wherein the bifurcated part comprises substantially parallel tubular limbs extending from the stented tubular part axially with respect to a longitudinal axis through the main lumen of the stented tubular part.5. The hybrid ...

CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL

Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device. 1. A coring device comprising:a coring cylinder configured for advancing through a tissue wall to define an aperture in the tissue wall by removing a tissue core from the tissue wall, the coring cylinder defining a coring bore extending along a longitudinal axis of the coring device and configured for receiving the tissue core therein; anda retrieval device configured for piercing the tissue wall, the retrieval device comprising a corkscrew configured for retaining the tissue core.2. The coring device of claim 1 , wherein the coring cylinder and the retrieval device are movable relative to one another in a direction of the longitudinal axis of the coring device.3. The coring device of claim 1 , wherein a longitudinal axis of the coring cylinder and a longitudinal axis of the retrieval device are coaxial with one another.4. The coring device of claim 3 , wherein the longitudinal axis of the coring cylinder and the longitudinal axis of the retrieval device are coaxial with the longitudinal axis of the coring device.5. The coring device of claim 1 , wherein the retrieval device is configured for piercing the tissue wall prior to removal of the tissue core from the tissue wall.6. The coring device of claim 1 , further comprising a handle engaged with the coring cylinder.7. ...

EMERGENCY VESSEL REPAIR PROSTHESIS DEPLOYMENT SYSTEM

A deployment device to deploy a prosthesis for interconnecting vessel portions of a body vessel is described herein. The device includes a support frame and an actuation member coupled to the support frame. The actuation member is movable between a first and a second position. A retaining member is movable between a closed and a open position. In the closed position, the retaining member forms a chamber to retain a length of a prosthesis in a compressed configuration. In the open position, the retaining member is positioned to allow the prosthesis to move to an expanded configuration. Movement of the actuation member to the second position causes movement of the retaining member to the open position. One or more retractable cuffs can be positioned over the ends of the prosthesis for selectively retaining the corresponding prosthesis ends in the compressed configuration. 117.-. (canceled)18. A method of treating a body vessel , comprising:introducing a deployment device having a prosthesis within a body, the system comprising a support frame and an actuation member coupled to the support frame, the actuation member movable relative to the support frame between a first position and a second position, a retaining member coupled to the support frame, the retaining member movable between a closed position and an open position, wherein when in the closed position the retaining member forms a retaining chamber to retain at least an intermediate length of the prosthesis in the radially compressed configuration, wherein the actuation member is in the first position and the retaining member is in the closed position;introducing a first outer end of the prosthesis into a first vessel portion of a body vessel;introducing a second outer end of the prosthesis into a second vessel portion of the body vessel; andmoving the actuation member from the first position to the second position, whereby the retaining member moves to the open position from the closed position to allow the ...

GRAFT PROSTHESIS COUPLER, MODULAR SYSTEM, AND METHODS OF USE

A graft prosthesis coupler includes a plurality of luminal grafts, each of which defines a first end, and a second end and a major longitudinal axis, the major longitudinal axes being substantially parallel to each other. The graft prosthesis coupler also includes a circumferential graft that has first and second ends and extends about the plurality of luminal grafts, and a first end wall that lies in a surface defined by the first ends of the luminal grafts and the first end of the circumferential graft. In another embodiment, a graft prosthesis coupler includes a plurality of luminal grafts attached to each other. A modular graft system includes the graft prosthesis coupler and branch graft prostheses. The graft prosthesis coupler can be implanted in a patient at a site of an aneurysm to facilitate implanting the branch graft prostheses into branch vessels at the site of the aneurysm. 1. A graft prosthesis coupler comprising:a) a plurality of luminal grafts, each of which defines a first end, a second end, an outside surface between the first end and the second end, and a longitudinal axis, the longitudinal axes being substantially parallel to each other;b) a circumferential graft that extends about and secures the plurality of luminal grafts relative to each other, the circumferential graft having a first end and a second end; andc) a first end wall that lies in a surface defined by the first ends of the luminal grafts and the first end of the circumferential graft.2. The graft prosthesis coupler of claim 1 , including two luminal grafts.3. The graft prosthesis coupler of claim 2 , wherein the two luminal grafts have diameters that are different from each other.4. The graft prosthesis coupler of claim 1 , including four luminal grafts.5. The graft prosthesis coupler of claim 4 , wherein the four luminal grafts have diameters that are about equal to each other.6. The graft prosthesis coupler of claim 5 , wherein the longitudinal axis of the four luminal grafts are ...

Tubular Graft

A tubular graft comprising an internal helical formation which imparts helical flow on fluid passing through the tubular graft. One end of the tubular graft is tapered from an inner base to an outer tip.

Vascular graft with compartments for compliance matching

A graft having a tubular body having a first end configured for attachment to a first vessel having a first compliance and second end configured for attachment to a second vessel having a second compliance different from the first compliance, and having a plurality of compressible chambers in the wall of the tubular body in which the chamber adjacent the first end of the tubular body is less compressible than the chamber adjacent the second end of the tubular body such that first end of the tubular body substantially matches the first compliance and the second end of the tubular body substantially matches the second compliance.

Longitudinally folded stent and method of using same

A stent assembly includes a framework having a tubular rest shape that defines a longitudinal axis, has an external surface that defines an expanded perimeter, and an internal surface that defines a passageway. The framework has a folded shape with a cross section perpendicular to the longitudinal axis that fits in a closed shape having a perimeter that is smaller than the expanded perimeter. The stent assembly has a constrained configuration characterized by the framework being held in the folded shape by a trigger wire supporting sheer stress by being in contact with interlaced loops of the framework. The stent assembly has an unconstrained configuration characterized by the framework being in the tubular rest shape with the trigger wire out of contact with the framework.

Suture material developed for end-to-end anastomosis

A suture material to be placed in blood vessels which is developed for end-to-end anastomosis of blood vessels with a lumen in microsurgery in a way to enable end-to-end suturing of blood vessels while at the same time increasing the success of vessel sutures and contributing to keeping the lumen open, wherein the straight wires form the body structure such that a rhombic lattice structure will be obtained, and then the oval wires are passed through the circles positioned at the end portions and knitted by the practitioner.

PERCUTANEOUS VASCULAR ANASTOMOSIS

Collapsible branched anastomosis devices allow for the formation of percutaneous vascular anastomoses using a Seldinger wire technique. This minimally invasive approach eliminates the need for a large surgical incision and also avoids the use of time consuming hand-suturing. The devices collapse to a fraction of their expanded volume and are configured to fit within a delivery sheath for over the wire delivery through a small incision in a blood vessel. 2100110120. The device of claim 1 , wherein the device () comprises a flexible material which is coated over the collapsible rings to form the main channel () and the branch channel ().3100160122126120. The device of claim 1 , wherein the device () additionally comprises a fourth collapsible ring () claim 1 , the ring coaxially disposed along axis B () claim 1 , inside the distal opening () of the branch channel ().4100100. The device of claim 1 , wherein the collapsible rings are configured to collapse towards their respective axes claim 1 , and the two axes are configured to collapse towards each other to yield a collapsed position of the device () with a collapsed diameter which is less than about 10% of an expanded diameter of the device ().5150152110112154110120. The device of claim 1 , wherein the third collapsible ring () comprises an angled barb () which interfaces with the main channel () and aligns with axis A () to set the angle () between the main channel () and the branch channel ().6150130140100. The device of claim 1 , wherein the third collapsible ring () is configured to fit in a space between the first collapsible ring () and the second collapsible ring () when the device () is collapsed.7100120. The device of claim 1 , wherein the device () is configured to fit inside a blood vessel claim 1 , with the branch channel () protruding from an incision in the blood vessel to form a vascular anastomosis.8120128125120. The device of claim 1 , wherein the branch channel () comprises radial spikes () to hold ...

MEDICAL DEVICE FOR USE WITH A STOMA

An device including a proximal portion adapted for placement intermediately within a hollow body cavity to capture and divert contents; the proximal portion being expandable from an initial state with an initial diameter, into an expanded state with a diameter greater than the initial diameter for engaging the proximal portion with an inner wall of the hollow body cavity; and a distal portion, connected to the proximal portion, adapted to extend through the abdominal wall or into the intestine to conduct the hollow body cavity contents out of the proximal portion. 1. A medical device comprising:a first end portion having a first aperture and defining a first diameter and configured to abut a first tissue surface;a second end portion having a second aperture and defining a second diameter and configured to abut a second tissue surface;a middle portion configured to form a passage between the first and second tissue surfaces, the middle portion defining a lumen that extends from the first aperture of the first end portion to the second aperture of the second end portion, the middle portion being situated between the first and second end portions and having a third diameter that is less than both the first and second diameters, the middle portion being adjustable from a first length to a second length to compress the first end portion toward the second end portion; anda cord operable to impart a compression force on the middle portion to compress the first end portion toward the second end portion.2. The medical device of claim 1 , wherein the middle portion is adjustable from the first length to the second length such that the third diameter is reduced.3. The medical device of claim 1 , wherein the cord is operable to be tensioned to compress the first end portion toward the second end portion.4. The medical device of claim 1 , wherein the middle portion is configured to adopt an accordion shape when adjusted from the first length to the second length.5. The medical ...