ВНУТРИСОСУДИСТЫЙ РАСШИРИТЕЛЬНЫЙ ИМПЛАНТАТ С ДЕФЛЕКТОРОМ

Изобретение относится к медицине, а именно к сосудистой хирургии. Изобретение обеспечивает снижение частоты рестеноза, в частности, с помощью действия на внутреннюю стенку артерии. Стент включает, по меньшей мере, один дефлектор потока, позволяющий отклонять направление потока в радиальном направлении в сторону артериальных стенок, что приводит к увеличению радиального градиента скорости у стенок артерии с локальным увеличением касательного напряжения на внутренней стенке артерии. Дефлектор потока обеспечен фиксирующими средствами, упирающимися в рабочем положении во внутреннюю стенку сосуда, причем указанные фиксирующие средства выполнены с возможностью предотвращения контакта дефлектора с внутренней стенкой сосуда и оказания механического действия для поддержания артериальной стенки. 2 с. и 12 з.п. ф-лы, 5 ил.

Intravaskulärer stent

Apparatus for use in coronary artery bypass surgery

The apparatus comprises a blood flow conduit 10 of T- or L-shape having a first end for insertion into and retention within a wall of a heart chamber 44 containing oxygenated blood and a second end for retention within a coronary artery 30, the conduit defining an open flow blood path during both systole and diastole. The conduit may be such as to bias forward flow of blood from the first towards the second end while not blocking reverse flow and may comprise a deflection surface for blocking flow through the conduit from impinging directly upon the coronary artery. Means may be provided in the conduit for reducing but not blocking blood flow during diastole.

Spiral flow testing

A tube 11 with an internal spiral flow-inducing formation is mounted within a flow system. The flow system has upstream 12 and downstream 13 tubing that deliver fluid to and from the tube 11. Transverse flow velocity is measured downstream by observing tomographic slices within a length 'L'. The tube 11 is characterised by computing a transverse flow signature from the measured velocity. The fluid may be blood or a suitable substitute with comparable density, viscosity, and acoustic refractive index. The flow velocity may be measured by Doppler ultrasound. A stenosis (figure 3) may be inserted downstream of the tube to determine the effect it has on the spiral flow induced by the tube. The effect is determined by introducing pressure sensing locations 14 into the upstream and downstream tubing.

Improving fluid flow in tubing

Flow means

There is a disclosed a conduit supporting structure 1a, 1b, 1c that imposes, maintains and/or reinforces a flow guiding formation of a conduit 4a, 4b, 4c, whereby to effect a desired flow configuration in the conduit. The invention is particularly directed to producing helical flow in medical grafts or stents, or in veins or arteries.

Aneurismal sack deflator

A tubular conduit with an internal and external helical formation

A tubular conduit (1) comprising a tubular portion (2) made from a flexible material. There is an external helical formation (7) extending around the exterior of, and parallel to the axis of, the tubular portion (2) and defining a first region of the tubular portion (2). The external helical formation (7) is for supporting the tubular portion (2). There is also an internal helical formation (10), protruding inwardly of the interior of the tubular portion (2) and extending parallel to the axis of the tubular portion (2) and defining a second region of the tubular portion (2). The internal helical formation (10) is for imparting helical flow on fluid passing through the tubular portion (2). The first region does not extend throughout the second region but may overlap the second region. An external helical formation may also be provided (11) corresponding to the internal helical formation (10) to provide some support for the conduit in the second region of the conduit. The arrangement provides ...

Implantable flow diverter

Prosthetic grafts

HOSES AND PIPES FOR MULTIPHASE FLOW

NARROWING IMPLANT

FORMED SURGICAL STENT

STENT FILTER ARRANGEMENT

Graft anchor devices, systems and methods

The present disclosure provides medical devices, systems and methods and in particular to devices and methods useful for anchoring graft materials to bodily structures.

Implantable damping device for modifying blood flow characteristics

An implantable damping device (100) for modifying blood flow characteristics in a vessel (50), the device (100) including: a first expansion chamber (110) having a first chamber proximal end (130), a first chamber distal end (170) and a first chamber intermediate portion (140) having a larger cross-sectional area than the first chamber proximal and distal ends (130), wherein the first expansion chamber (110) generates a pressure drop in blood flow downstream of the device (100) relative to blood flow upstream of the device (100).

Method for determining the deployed position of an implantable medical device after expansion in a vascular structure

The invention relates to a method for determining the deployed position of an implant in the form of an expandable medical device, which method, starting from a three-dimensional image of a region of interest comprising the vascular structure, comprises the following steps: determining a central line of the vascular structure, positioning the IMD in an initial position around the central line, simulating the final position of the IMD after deployment, depending on the stresses exerted on the IMD by the walls of the vascular structure, the determination of the central line consisting in placing points in such a way as to minimize a fluid transit time along said points between an inlet point and an outlet point, the transit time being minimized by using a gradient descent algorithm, the simulation of the final position of the IMD taking into account a rate of longitudinal compression intended to be applied to the IMD during the implantation of the latter. Figure 2 ...

Device for filtering blood in a vessel with helical elements

A helical formation for a conduit

IMPLANTABLE PRESSURE ATTENUATION DEVICE

Artificial valve prosthesis with improved flow dynamics

INTRAVASCULAR FLOW RESTRICTOR

Branched vessel endoluminal device

An endoluminal prosthesis (520) comprises a prosthetic trunk having a trunk lumen and a trunk wall, a first prosthetic branch (533) having a first branch lumen and a branch wall, and a second prosthetic branch (534) having a second branch lumen. The first branch lumen and the second branch lumen are both in fluid communication with the trunk lumen through the trunk wall and the second branch lumen is in fluid communication with the first branch lumen through the branch wall. Additional devices, systems, and methods are disclosed.

Devices and methods for reshaping blood vessels

Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction.

Blood pump

Apparatus and methods are described including a catheter (20), a first pump (24U) disposed on the catheter, and a second pump (24D) disposed on the catheter, proximally to the first pump. A control unit (52) is configured to control activation of the first and second pumps. The first and second pumps are configured, when activated, to pump fluid in opposite directions from one another. Other applications are also described.

ARTIFICIAL GRAFT TUBING

A method of making artificial graft tubing is disclosed. The method comprises providing a helical mandrel having a centre line following a substantially helical path, providing a generally tubular wall having a longitudinally extending cavity, positioning the helical mandrel inside the tubular wall so that the longitudinally extending cavity has a centre line following a substantially helical path, and causing the tubular wall to retain, at least partly, the shape with the longitudinally extending helical cavity. Another method comprises providing a mandrel having a substantially helical groove, providing a generally tubular wall having a longitudinally extending cavity, positioning the tubular wall at least partly in the groove so that the longitudinally extending cavity has a centre line following a substantially helical path, and causing the tubular wall to retain, at least partly, the shape with the longitudinally extending helical cavity.

NARROWING IMPLANT

A reducer implant for insertion in a blood vessel, for reducing an inner diameter of said vessel and flow therethrough, having at least one narrowed section having a first diameter; and at least one flared section having a diameter substantially greater than said first diameter. Optionally, the reducer is formed of a material and has a geometry that does not cause coagulation of blood in its vicinity.

HELICAL GRAFT

A graft comprising flow tubing having a tubing portion (1) defining a flow lumen, the flow lumen of said tubing portion being substantially free of ribs or grooves, wherein the centre line of the flow lumen follows a substantially helical path with a helix angle less than or equal to 65~, and wherein the amplitude (A) of the helix is less than or equal to one half of the internal diameter (Di) of the tubing portion.

PARTIAL AORTIC OCCLUSION DEVICES AND METHODS FOR CEREBRAL PERFUSION AUGMENTATION

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter (102) and a distally mounted expandable member (104).The expandable member (104) may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

FLUID FLOW PROSTHETIC DEVICE

... ²²²Apparatus is provided, including a prosthetic device, having a single flow ²field therethrough, adapted for implantation in a subject, and shaped so as to ²define a fluid inlet and a diverging section, distal to the fluid inlet. The ²prosthetic device includes a plurality of axially-extending struts (112) which ²extend along at least a portion of the diverging section and diverge ²outwardly, such that distal ends of the struts are spaced further from one ²another than proximal ends of the struts thoughout a cardiac cycle of the ²subject. The diverging section includes a diverging envelope (111), coupled to ²the struts, which is adapted to assume an open position thereof during ²systole, permitting blood flow through the device, and which is adapted to ²collapse to a closed position thereof during diastole, inhibiting blood flow ²through the device.² ...

METHOD AND APPARATUS FOR STENTING

A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. First stent segment (12), second stent segment (14) and thrid stent segement (16) show a schematic view of the stent envelope or profile.

MULTIVASCULAR NETWORKS AND FUNCTIONAL INTRAVASCULAR TOPOLOGIES WITHIN BIOCOMPATIBLE HYDROGELS

A device made from a hydrogel matrix is provided. The hydrogel matrix includes a photoabsorber with a void architecture in the matrix, having a first vessel architecture and a second vessel architecture that are each tubular and branching, wherein the first and second vessel architectures are fluidically independent from each other. A pre-polymerization solution for forming the device, and methods of fabricating such devices are described. A method of fabricating a 3D hydrogel construct is provided. The method includes using a computer-implemented process to create a 3D model of the construct based on a tessellation of polyhedra having a number of faces connected by edges and vertices, generate a first vascular component of the model, generate a second vascular component of the model, and combine the first and second vascular components of the model.

A FLUID FLOW CONTROLLER

A fluid pathway (36) provided with a flow controller (37) in at least a portion of its length wherein the flow controller (37) comprises an active surface capable of influencing the fluid flow (34) through the fluid pathway (36), the configuration of the active surface conforming to at least one logarithmic curve conforming to the Golden Section.

IMPLANTABLE PROSTHETIC DEVICES PARTICULARLY FOR TRANSARTERIAL DELIVERY IN THE TREATMENT OF AORTIC STENOSIS, AND METHODS OF IMPLANTING SUCH DEVICES

... ²²²Prosthetic devices as described for use in the treatment of aortic stenosis in ²the aortic valve of a patient's heart, the prosthetic device having a ²compressed state for transarterial delivery and being expandable to an ²expanded state for implantation. The prosthetic device includes an expandable ²metal base (10) constructed so as to be implantable in the expanded state of ²the prosthetic device in the aortic annulus of the aortic valve; and an inner ²envelope lining (11) tune inner surface of the metal base (10). The inner ²envelope, in the expanded state of the prosthetic device, extends into the ²aorta and is of a diverging conical configuration, in which its diameter ²gradually increases from its proximal end within the aortic annulus to its ²distal end extending into the aorta, such as to produce, during systole, a non-²turbulent blood flow into the aorta with pressure recovery at the distal end ²of the inner envelope. Preferably, the distal end includes a prosthetic valve ²which ...

FLOW RESTRICTING STENT-GRAFT

The presently described stent-graft includes a stent frame forming a cavity and frame wires extending around the stent frame perimeter. The stent frame is formed such that the cavity cross sectional area decreases along a first length of a flow restricting section to a cavity minimum cross sectional area and increases along a second length of the flow restricting section. The first length extends from a cavity proximal cross sectional area to the cavity minimum cross sectional area and the second length extends from the cavity minimum cross sectional area to a cavity distal cross sectional area. When placed within a patient's aorta, the stent-graft may help the treatment of congestive heart failure by increasing blood flow to the kidneys. The provided stent-graft may also be adapted for placement within a patient's urethra to help the treatment of urinary incontinence.

ARTIFICIAL VASCULAR GRAFT

The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.

VASCULAR IMPLANT

An implant for implantation in a lumen includes a plurality of struts, with intervening openings therebetween. The implant also includes narrow connecting pieces, bridging at least some of the openings so as to interconnect the struts. Exertion of a first outward radial force on the struts causes the implant to open to a first diameter by opening the intervening openings between the struts. The narrow connecting pieces are adapted to break under exertion on the struts of a second outward radial force, greater than the first outward radial force, so that the implant opens to a second diameter, greater than the first diameter.

FLOW REDUCING IMPLANT

A flow reducing implant which includes a flared section adapted to contact a blood vessel wall. The flow reducing implant also includes at least one narrowed section continuous with the flared section. The implant is defined by a sheet material with slots and wherein a width of the slots varies over the implant to control a geometry of the implant.

SEALING APPARATUS AND METHODS OF USE

A system for treating an aneurysm comprises at least a first double-walled filling structure having an outer wall and an inner wall and the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The first filling structure comprises a sealing feature which forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium, thereby minimizing or preventing blood flow downstream of the seal.

PROSTHETIC VALVE WITH AN ELASTIC STENT AND A SEALING STRUCTURE

The present disclosure concerns a prosthetic valve comprising a tubular elastic stent having a distal end and a proximal end with a passage extending from the distal end to the proximal end of the elastic stent, a valve positioned within the passage, and an annular sealing structure positioned on an exterior of the elastic stent at the distal end of the elastic stent, the sealing structure forming a protrusion and comprising an inflatable cuff.

REMOVABLE BLOOD CONDUIT FILTER

... ²²²²The present invention relates to a non-evertable blood filter that divides the ²transverse ²cross sectional area of a venous vessel into three annular regions or zones. ²The inner ²zone, the region immediately surrounding the longitudinal axis of the vessel, ²is²maintained in a relatively open state with only minimal interference from the ²members ²making up the filter device so that blood flow can be maintained at a ²relatively normal ²rate. Concentrically surrounding the inner zone is the intermediate zone, to ²which ²captured emboli are directed out of the bloodstream passing primarily through ²the inner ²zone. Finally, concentrically surrounding the intermediate zone is the outer ²zone ²adjacent to the vessel wall. This is also intended to be kept free of emboli, ²so that ²emboli in the bloodstream immediately adjacent the vessel wall are directed ²away from ²the wall by the filter design and into the intermediate zone, thereby avoiding ²the ²accumulation of emboli adjacent the ...

METHOD AND APPARATUS FOR POLISHING SURGICAL STENTS

A method for polishing radially expandable surgical stents is disclosed where fluid abrasive media M flows over surfaces of the stent (10) causing the surfaces of the stent (10) to be polished and streamlined. The stent (10) is temporarily provided with cylindrical support ends (20), which are not radially expandable to support the stent (10) during the polishing process. An interior polishing fixture (100) is provided which has cylindrical chambers (135) therein adapted to receive a stent (10) therein. Fluid abrasive media M then flows into bores (108) in the fixture (100) leading to the cylindrical chambers (135) and adjacent the inner diameter surfaces of the stent (10). Surfaces of the stent (10) forming the outer diameter are polished by placing the stent (10) within an exterior polishing fixture (200) which has a cylindrical recess (220) therein. The cylindrical recess (220) has a diameter greater than a diameter of outer surfaces of the stent (10) and includes a cylindrical shaft ...

Implant expansion intravascular deflector.

Adjustable multilumen stent.

Ein einstellbarer mehrlumiger Stent zur interventionellen Reduktion des Blutflusses in einem Blutgefäss, wobei der mehrlumige Stent einen Hauptkörper (10) mit einem proximalen Ende (1) und einem distalen Ende (2) aufweist, der Hauptkörper (10) ein inneres rohrförmiges Segment (3), das ein zentrales Lumen (4) des mehrlumigen Stents definiert, und ein äusseres rohrförmiges Segment (5) aufweist, das ein äusseres Lumen (6) des mehrlumigen Stents zwischen einer Innenfläche (8) des äusseren rohrförmigen Segments (5) und einer Aussenfläche des inneren rohrförmigen Segments (3) definiert; das zentrale Lumen (4) im Durchmesser einstellbar ist und eine Fluidverbindung zwischen dem proximalen Ende (1) und dem distalen Ende (2) des mehrlumigen Stents bereitstellt; das äussere Lumen (6) an seinem distalen Ende (2) durch ein ringförmiges deckelartiges Segment (7) verschlossen ist, welches das innere rohrförmige Segment (3) mit dem äusseren rohrförmigen Segment (5) verbindet und an dem proximalen Ende ...

Valve cardiaque prothétique mécanique.

La présente invention concerne une valve cardiaque prothétique mécanique (10) comportant un support annulaire (12) comprenant une paroi périphérique interne centrée autour d'un axe longitudinal (X) et délimitant un passage interne, et trois volets mobiles, agencés de manière à pouvoir effectuer chacun un mouvement de rotation autour d'un axe de rotation perpendiculaire audit axe longitudinal (X) afin que la valve (10) puisque passer d'une configuration ouverte à une configuration fermée. Chaque volet comporte une partie centrale (46) et deux ailes latérales encadrant la partie centrale (46) de façon symétrique par rapport à un plan de symétrie du volet et étant inclinées par rapport à ladite partie centrale. Chaque aile latérale comporte une portion terminale. Le support annulaire (12) comporte deux bords opposés (26, 28) et trois extensions (30) qui s'étendent axialement à partir d'un des deux bords opposés. Le support annulaire (12) comporte en outre sur la paroi périphérique interne ...

УСТРОЙСТВО ДЛЯ ИЗМЕНЕНИЯ ПАРАМЕТРОВ ПОТОКА ТЕКУЧЕЙ СРЕДЫ

Изобретение относится к трубопроводу для текучей среды, снабженному по меньшей мере на одном из его участков устройством для управления потоком, которое имеет активную поверхность, выполненную с возможностью воздействия на прохождение текучей среды по трубопроводу, причем конфигурация активной поверхности соответствует по меньшей мере одной логарифмической кривой, соответствующей Золотому Сечению.

COLLAPSIBLE MEDICAL DEVICE - INTRAVASCULAR FLOW RESTRICTOR

미세도관 제조 방법

... 본 발명의 일 실시예는 환자의 혈관 및 동맥류의 3차원적 기하구조를 포함하는 혈관정보를 생성하는 단계와, 혈관정보 중 동맥류와 동맥류에 연결된 환자의 표적혈관의 3차원적 기하구조를 포함하는 표적혈관정보를 선별하는 단계와, 표적혈관정보를 분석하여 환자의 표적혈관 및 동맥류의 3차원적 중심선(centerline)을 추출하는 단계와, 3차원적 중심선을 3차원 중심선이 내부에 배치되는 가상의 정육면체의 각 변의 길이를 각각 확대하는 3차원 확대(three-dimensional enlargement)를 실시하여 3차원적 확대 중심선을 생성하는 단계와, 3차원적 확대 중심선에 대응하도록 색전술용 미세도관을 제조하는 단계를 포함하고, 환자의 표적혈관 및 동맥류의 내부에서 3차원적 중심선이 지나가는 경로와 3차원적 확대 중심선이 지나가는 경로는 상이하게 형성되는 미세도관 제조 방법을 개시한다.

METHODS AND APPARATUS FOR ACTIVE OR PASSIVE ASSISTANCE IN THE CIRCULATORY SYSTEM

Apparatus and methods for assisting flow of a fluid in a conduit. In some embodiments, a viscous impeller rotating within a protective cage provides a boost and total pressure to blood within the circulatory system of an animal.

STENT

A bioabsorable stent is disclosed. The stent is made of a bioabsorable, polymer and/or non-polymer material and has an elongated body having a proximate end, a distal end, and at least one open channel formed on the exterior surface of the elongated body to provide fluid communication between the proximal end and the distal end. Also disclosed is a bioabsorable stent having an elongated center rod having a proximate end and a distal end and a plurality of leaflets extending outward from the center rod and forming channels between two neighboring leaflets to provide fluid communication between the proximal end and the distal end.

Implantable damping devices for treating dementia and associated systems and methods of use

Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device configured in accordance with embodiments of the present technology can include an anchoring member coupled to a flexible, compliant damping member including a generally tubular sidewall having an outer surface, an inner surface defining a lumen configured to direct blood flow, a first end portion and a second end portion, and a damping region between the first and second end portions. The inner and outer surfaces of the damping member can be spaced apart by a distance greater at the damping region than at the first or second end portions. When blood flows through the damping member during systole, the damping member absorbs a portion of the pulsatile energy of the blood, thereby reducing a magnitude of the pulse pressure transmitted to a portion of the blood vessel distal to the damping device.

METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE

Implantable medical devices adapted to modify fluid flow within a body vessel are provided herein. The medical devices may include a fluid flow restricting channel configured to reduce longitudinal fluid flow in a retrograde direction or in an antegrade direction. Preferably, the medical devices are flow-modifying devices that reduce fluid flow through the medical device to a greater extent in a retrograde direction than in an antegrade direction. Methods of treatment comprising the step of implanting a flow-modifying medical device within a body vessel are also provided. Flow-modifying devices are useful, for example, in treating venous valve related conditions.

Fenestration with intrinsic means of selective closure incorporated to a tubular body and used in interventional cardiovascular procedures

A first arched surface (2) having a lower end fenestration (4), protruding from a tubular body (1), intersecting it along a closed oval perimeter (5). A second arched surface (7) placed with body (1) facing first surface (2), with an upper opening (8). Both surfaces (2,7) are related through this same perimeter (5) with identical cross sections. Body (1) and both arched surfaces (2,7) are made of a waterproof material. Surface (7) is elastically deformed along said perimeter (5), having means capable of displacing it between two operative positions. When both surfaces (2,7) have opposed convexities of different sign, they establish a passage (9) communicating inner tubular body (6) through said opening (8) and fenestration (4). When surface (7) acquires a same sign convexity to first surface (2), it settles against the inside of (2) closing passage (9), fenestration 4 and opening (8), with a sealing relationship.

STENT WITH HELICAL GROOVE

Disclosed herein is an intraluminal support device having a groove formed therein, and a method of making such a support device. The device has an improved architecture in which the ring-shaped segments are joined by connectors that are spaced at even intervals from the groove in order to maintain a consistent radial force profile and stabilize the device.

Monolithic medical devices, methods of making and using the same

The monolithic device comprises a plurality of scaffolding members and a mesh patterned members webbed between the scaffolding members; the mesh patterned member webbed between the scaffolding members surround a lumen and generally expands from a contracted state to an expanded state; and mesh patterned members including a plurality of openings traversing the thickness of the mesh patterned member, and the mesh patterned members including a surface on which a pattern of openings is formed.

Flow reducing implant

A flow reducing implant for reducing blood flow in a blood vessel having a cross sectional dimension, the flow reducing implant comprising a hollow element adapted for placement in the blood vessel defining a flow passage therethrough, said flow passage comprising at least two sections, one with a larger diameter and one with a smaller diameter, wherein said smaller diameter is smaller than a cross section of the blood vessel. A plurality of tabs anchor, generally parallel to the blood vessel wall, are provided in some embodiments of the invention.

BIOABSORBABLE FLOW DIVERTING SCAFFOLD

This disclosure relates to scaffolds made of a braid of bioabsorbable polymeric fibers for implantation within a lumen of a mammalian body and, in particular, to such scaffolds that are configured to divert blood flow from a pathology associated with a blood vessel.

Partial aortic occlusion devices and methods for cerebral perfusion augmentation

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

Ez lift

An apparatus for accessing products stored in standing containers. The apparatus comprises a container member having each of a first predetermined shape and formed of a predetermined material. The container member has a slot formed into a side of such container member. A flexlift member having a second predetermined shape is engageable with the slot formed on the side of the container. A lift member is engageable with the flexlift member for raising such product disposed in the container when such flexlift member is pushed downward. A bottom cap member is engageable with a bottom portion of the container member for closing off the bottom of the container. A track cover for engagement with a portion of the flexlift member and is further engageable with the bottom cap member. A top cap member is engageable with a top portion of the container member for closing off the top of the container member thereby keeping products stored therein from falling out.

Helical stent

A stent for insertion in a fluid conduit of a human or animal body when the stent is in a collapsed condition and for expansion to an expanded condition, includes an outer wall for engagement with the conduit. The outer wall has a helical portion which in the expanded condition extends longitudinally and circumferentially, and which, upon expansion of the stent from the collapsed condition to the expanded condition, resists extension.

DEVICE AND METHOD FOR TREATING ISCHEMIC HEART DISEASE

A narrowing intraluminal stent is disclosed and comprises a hollow body and a flow passage therethrough, the hollow body designed for intraluminal placement and having at least one portion of an inner cross sectional dimension smaller than the cross sectional dimension of the lumen, so as to artificially narrow a passage through the body lumen. A method of artificially narrowing a passage through a body lumen using the stent is also disclosed.

Pulmonary artery implant apparatus and methods of use thereof

The present invention relates to an implantable apparatus and methods of use thereof for treating congestive heart failure. An apparatus of this invention may be anchored by implantation of a section of the apparatus within in a branch pulmonary artery, for example the left pulmonary artery, which then positions and anchors another section, for example a device frame section of the apparatus within the main pulmonary artery. A medical device may be attached to the anchored device frame.

Subcutaneous vascular assemblies for improving blood flow and related devices and methods

Medical devices and related method for improving blood flow to regions of a patient are described herein. Some medical devices may include a first graft portion, a second graft portion, and a catheter portion disposed between the first graft portion and the second graft portion. The medical device may be implanted into a patient to establish a non-natural flow path.

Helical stent

A stent (2) for insertion in a fluid conduit of the human or animal body when the stent is in a collapsed condition and for expansion to an expanded condition, the stent comprising an outer wall(7) for engagement with the conduit, the outer wall having a helical portion (6) which in the expanded condition extends longitudinally and circumferentially, and which, upon expansion of the stent from the collapsed condition to the expanded condition, resists extension.

A TUBULAR CONDUIT

Surgical access port

The present invention relates to an apparatus for use in a coronary bypass procedure at a coronary vessel on a heart wall, said apparatus comprising a conduit having first and second arms each having first and second ends, the configuration and sizes of the conduit being such that when the said first arm is inserted into said heart chamber so that its end is in blood flow communication with blood contained within said chamber, the second arm can extend exterior of the heart wall for connection with a neighbouring coronary vessel, such that its second end is in blood flow communication therewith.

Reduction stent and device with this stent

УСТРОЙСТВО ДЛЯ ИМПЛАНТАЦИИ В СОСУДАХ И ПОЛЫХ ОРГАНАХ (ЕГО ВАРИАНТЫ)

Изобретение относится к медицинской технике, в частности для сосудистой хирургии. Устройство представляет собой вязаную конструкцию, образованную из множества рядов жестко соединенных между собой ромбических ячеек с различными соотношениями размеров осей, каждая из которых соединена между собой вершинами посредством неразъемных узлов, при этом ячейка является жестко замкнутым функциональным элементом и ячейка каждого последующего ряда смещена относительно ячейки предыдущего ряда на 1/2 оси ромба. Возможен вариант, когда устройство образовано множеством жестко соединенных между собой рядов (прямоугольных или трапецеидальных) ячеек, каждая из которых соединена между собой углами посредством неразъемных узлов, при этом ячейка является жестко замкнутым функциональным элементом. 2 с.п.ф-лы, 7 ил.

Stent und Verfahren und Vorrichtung zur Herstellung des Stents

Stent sowie Verfahren und Vorrichtung zur Herstellung des Stents, wobei der Stent eine rohrähnliche, einzelne Struts umfassende Gitterstruktur und wenigstens einen Strut aufweist, von dem wenigstens ein Längenabschnitt mit wenigstens einer Richtungskomponente in radialer Umfangsrichtung des Stents verläuft, wobei die zur Außenseite des Stents gerichtete Längenabschnitts-Oberfläche lediglich um die Längsachse des Stents gekrümmt ist. Erfindungsgemäß weist die zur Innenseite des Stents gerichtete Oberfläche des Strut-Längenabschnittes eine derartige Wölbung auf, dass der Strutquerschnitt strömungstechnisch optimiert ist.

VERBESSERUNG DES DURCHFLUSSES IN FLUSSLINIEN

A tubular conduit

Implantable flow diverter

A flow diverter 10 for implantation into a patient's blood vessel includes a distal annular support element 12 and a proximal annular support element 14 which support a longitudinally twisted diverter panel 16. Preferably the panel twists through a quarterturn and it may contain slits (figure 6). The supports may be ringshaped and may be split rings that are radially compressible. They may be made from spring steel or a shapememory alloy. The flow diverter imparts a rotational or twisting motion to the flow of blood to reduce the pressure of blood at the centre of the vessel (40, figure 12) and may be used in the treatment of aneurysms occurring at the bifurcation between the basilar artery and the posterior cerebral arteries.

Spiral flow testing

Vascular graft

A tubular conduit

DEVICE FOR EXECUTION A KORONAREN ARTERIENBYPASSOPERATION

PROCEDURE FOR BRINGING AN INTERNAL SCREW-SHAPED ARRANGEMENT INTO A FLEXIBLE TUBULAR MATERIAL

INTRAVASKULÄRER STENT

SPIRAL DEVICE FOR A PIPE

SPIRAL EMPLOYMENT FOR A PIPE

EMF�NGNISVERH�TUNGSVORRICHTUNG

CONTAINER PROSTHESIS

PLACEMENT DEVICE FOR A PROSTHESIS ON A BODY TUBE

SCHIEBEUND ARRETIERSTENT

IMPLANTIERBARE FLAP PROSTHESIS

SPIRAL STENT

MORE INTRAVASKULÄRER FLUSSRESTRIKTOR

Implantable flow diversion device

Apparatus and methods for treating congestive heart disease

In situ formable and self-forming intravascular flow modifier (ifm), catheter and ifm assembly, and method for deployment of same

Implantable stroke preventing device

Method and apparatus for polishing surgical stents

Means for effecting a fluid flow pattern in a conduit

Implantable valvular prothesis

Sealing apparatus and methods of use

Implantable damping devices for treating dementia and associated systems and methods of use

Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device (100) configured in accordance with embodiments of the present technology can include an anchoring member (104) coupled to a flexible, compliant damping member (102) including a generally tubular sidewall having an outer surface (115), an inner surface (113) defining a lumen configured to direct blood flow, a first end portion (106) and a second end portion (108), and a damping region (120) between the first and second end portions (106, 108). The inner and outer surfaces (113, 115) of the damping member (102) can be spaced apart by a distance that is greater at the damping region (120) than at either of the first or second end portions (106, 108). When blood flows through the damping member (102) during systole, the damping member (102) absorbs a portion of the pulsatile energy of the blood, thereby reducing a magnitude of the pulse pressure transmitted to a portion of the blood vessel ...

Three-dimensional thin-film nitinol devices

A method of manufacturing three-dimensional thin-film nitinol (NiTi) devices includes: depositing multiple layers of nitinol and sacrificial material on a substrate. A three-dimensional thin-film nitinol device may include a first layer of nitinol and a second layer of nitinol bonded to the first layer at an area masked and not covered by the sacrificial material during deposition of the second layer.

Treatment of tricuspid insufficiency

A tricuspid insufficiency treatment device includes a vena cava member (12) implantable in a vena cava of a patient. The vena cava member (12) is formed with a fenestration (14) and further includes a blocking member (16) arranged to block and unblock the fenestration (14).

Implantable damping device for modifying blood flow characteristics

Implantable damping device for modifying blood flow characteristics Abstract An implantable damping device (100) for modifying blood flow characteristics in a vessel (50), the device (100) including: a first expansion chamber (110) having a first chamber proximal end (130), a first chamber distal end (170) and a first chamber intermediate portion (140) having a larger cross-sectional area than the first chamber proximal and distal ends (130, 170), a wrap (500) configured to be wrapped externally around a portion of the vessel (50) at a location which is radially external to a portion of the first expansion chamber (110), wherein the first expansion chamber (110) generates a pressure drop in blood flow downstream of the device (100) relative to blood flow upstream of the device (100). - .50 Fig. 12 600 Fig. 13 10 600 -< 7 --- Fig. 14 100 600 Fig. 15 ...

METHODS OF RETROPERFUSION AND RELATED DEVICES

Flow-Deflecting Medical Device

The disclosure relates to a flow-deflecting medical device comprising a support structure and two flow-deflecting members attached to the support structure. The first flow-deflecting member is movable to a position in which it contacts and substantially seals against the second flow-deflecting member.

Blood-flow tubing

An artificial or modified natural blood flow tubing has a helical-flow inducer to induce helical flow in such a fashion as to eliminate or reduce turbulence. One inducer is a tubular stent of expansible mesh having a helical vane.

Devices and methods for in situ fenestration of a stent-graft at the site of a branch vessel

The present disclosure includes a stent-graft comprising a first portion that is configured to engage a vessel wall, a second portion that is configured not to engage the vessel wall, and a perfusion window that is configured to permit blood flow. The stent-graft may further comprise a transition portion between the first portion and the second portion, and the perfusion window may be formed in the first portion, the second portion, and/or the transition portion. In a variety of embodiments, one of the first and the second portion may have a smaller diameter than the other. Similarly, in a variety of embodiments, the transition portion may be frustoconically shaped.

Venous nitinol embolization inserts

A venous nitinol embolization insert for restricting blood flow includes a tubular member and an embolization material attached to the tubular member. The embolization insert provides a predetermined blood flow rate based on experimental data. A method of controlling restriction of blood flow to a targeted vascular site within a patient's body includes selecting an insert that provides a predetermined blood flow rate corresponding to a desired blood flow rate. The embolization insert is selected from a plurality of embolization inserts that provide varied blood flow rates.

Intralumenally-implantable frames

Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.

Blood flow controllers and methods

Blood flow restrictors are discussed. In some examples, a blood flow restrictor apparatus is configured to be placed within a destination vessel for an arteriovenous hemodialysis access. In an example, the apparatus includes a tubular portion including a delivery configuration and a deployed configuration. In a further example, a size-limiting portion is configured to constrain a size of the tubular portion in the deployed configuration. The tubular portion, in some examples, includes a first portion including a first size substantially matching an interior size of the destination vessel with the tubular portion in the deployed configuration. In another example, the tubular portion includes a second portion constrained by the size-limiting portion to include a second size smaller than the first size of the tubular portion.

EXPANDABLE VASCULAR OCCLUSION DEVICE WITH LEAD FRAMING COIL

A method of treating an aneurysm with an occlusion device having an inner embolic device with a proximal section and a distal section. The distal section has a first stiffness and the proximal section has a second stiffness. Further, the device has an expandable mesh capable of a collapsed position and an expanded position. The mesh can be disposed over, and attached to, a portion of the proximal section of the inner embolic device. The first stiffness is greater than the second stiffness and the inner embolic device comprises a preselected shape which assists in transforming the expandable mesh from the collapsed position to the expanded position. 1. A method of treating an aneurysm using an occlusion device having an inner embolic element with a proximal section and a distal section , and an expandable mesh , comprising the steps of:providing a first stiffness for the distal section;providing a second stiffness for the proximal section different from the first stiffness;disposing the expandable mesh over a portion of the proximal section of the inner embolic element;placing the occlusion device within a vessel of a patient;directing the occlusion device to the aneurysm;deploying the distal section of the inner embolic element into the aneurysm from a catheter;assuming, by the distal section of the inner embolic element, a predetermined shape;permanently deploying the expandable mesh into the aneurysm.2. The method of wherein the distal section of the inner embolic element is a framing coil claim 1 , and further comprising the step of configuring the different stiffness of inner embolic element so that the framing coil is stiffer than the proximal section.3. The method of claim 1 , wherein the distal section has a stiffness that is at least ten times the stiffness of the proximal section.4. The method of claim 1 , wherein the distal section has a stiffness that is up to twenty times stiffer than the proximal section.5. The method of claim 1 , wherein the distal ...

Force transducting inflatable implant system including a dual force annular transduction implant

An implant system for restoring and improving physiological intracardiac vortical flow in a human heart is provided including a dual force transducting annular implant comprising laterally extending struts transitioning into annular structural members for positioning on the atrial side of the valve annulus; an anchoring system comprising a therapeutic base plate assembly attachable to the apex of the heart; and a tether assembly comprising a tether connected between the implant and the therapeutic base plate assembly.

IMPLANTABLE DAMPING DEVICES FOR TREATING DEMENTIA AND ASSOCIATED SYSTEMS AND METHODS OF USE

Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device configured in accordance with embodiments of the present technology can include an anchoring member coupled to a flexible, compliant damping member including a generally tubular sidewall having an outer surface, an inner surface defining a lumen configured to direct blood flow, a first end portion and a second end portion, and a damping region between the first and second end portions. The inner and outer surfaces of the damping member can be spaced apart by a distance that is greater at the damping region than at either of the first or second end portions. When blood flows through the damping member during systole, the damping member absorbs a portion of the pulsatile energy of the blood, thereby reducing a magnitude of the pulse pressure transmitted to a portion of the blood vessel distal to the damping device. 1. A device for treating or slowing the effects of dementia by lowering the peak of the blood pressure wave , the device comprising:an anchoring member comprising a generally cylindrical mesh structure configured to expand from a low-profile state to a deployed state; anda tubular damping member within the mesh structure, the damping member having a low-profile configuration and a deployed configuration, wherein the damping member includes an outer sidewall, an inner sidewall, and a cavity therebetween, wherein the inner sidewall has a plurality of undulations and defines a lumen extending through the damping member, and wherein the cavity is at least partially filled with a fluid comprising a plurality of fluid particles,wherein the device is configured to be deployed within a blood vessel lumen such that an outer surface of the anchoring member is in apposition with an inner surface of the blood vessel wall and an outer surface of the inner sidewall of the damping member is in contact with blood flowing through the blood vessel lumen, andwhen the ...

Combinatorial therapies including implantable damping devices and therapeutic agents for treating a condition and associated systems and methods of use

Devices, systems, and methods for combinatorial treatment of a condition with an implantable damping device and therapeutic agent (e.g., drug) are disclosed herein. Methods for treating one or more effects of the condition, such as a neurological condition, include providing the implantable damping device and at least neck one other therapy, such as a therapeutic agent, that treats the condition to the patient. The implantable damping device includes a flexible damping member and an abating substance and can be placed in apposition with a blood vessel. The flexible damping member forms a generally tubular structure having an inner and an outer surface, the inner surface formed of a sidewall having a partially deformable portion. The abating substance is disposed within the partially deformable portion and moves longitudinally and/or radially within the partially deformable portion in response to pulsatile blood flow.

FORCE TRANSDUCTING INFLATABLE IMPLANT SYSTEM INCLUDING A DUAL FORCE ANNULAR TRANSDUCTION IMPLANT

An implant system for restoring and improving physiological intracardiac vortical flow in a human heart is provided including a dual force transducting annular implant comprising laterally extending struts transitioning into annular structural members for positioning on the atrial side of the valve annulus; an anchoring system comprising a therapeutic base plate assembly attachable to the apex of the heart; and a tether assembly comprising a tether connected between the implant and the therapeutic base plate assembly. 1. An implant system for restoring ventricular geometric shape and changing vortical physiological intracardiac flow (ventricular vortex) in a human heart comprising:a dual force transducting annular implant comprising laterally extending struts transitioning into annular structural components for positioning the implant and transducting force on the atrial side of a valve annulus;an anchoring system comprising one or more therapeutic base plate assemblies attachable to the heart's apex or wall;a tether assembly, comprising a tether or tethers or shaft, connected between the implant and the one or more therapeutic base plate assemblies;a conduit providing a fluidic connection; anda control unit.2101-. (canceled) This application claims the benefit of priority under 35 USC § 120 to U.S. patent application Ser. No. 16/021,985, filed Jun. 28, 2018, which claims the benefit under 35 USC § 119(e) of U.S. Provisional Application Ser. No. 62/526,216, filed Jun. 28, 2017, each of which is hereby incorporated by reference in its entirety.The present disclosure relates generally to a force transducting, structurally stabilizing, vortex orienting or steering, and functionally ventricular assisting inflatable implant within a human heart for restoring and improving physiologic vortical intracardiac flow and utilizing the re-purposed native energy and force of the atrioventricular pressure gradient, via force transduction, to restore geometric elliptical shape, ...

STENT AND METHOD AND DEVICE FOR FABRICATING THE STENT

Device, system and method for fabricating a stent, the device including a reservoir that provides a supply of particles; an appliance having a high pressure generator that generates a particle beam from the supply of particles; a transport conduit that transports the particle beam; and a nozzle connected to the transport conduit that jets the particle beam outward from the device, where the nozzle is configured for insertion into a stent. 1. A device for fabricating a stent , the device comprising:a) a reservoir that provides a supply of particles;b) an appliance comprising a high pressure generator that generates a particle beam from the supply of particles;c) a transport conduit that transports the particle beam; andd) a nozzle connected to the transport conduit that jets the particle beam outward from the device, wherein the nozzle is configured for insertion into a stent.2. The device of claim 1 , wherein the particles comprise sand or pellets.3. The device of claim 1 , wherein the nozzle is configured to scatter the particle beam to strike struts of a stent laterally along a luminal surface.4. The device of claim 1 , wherein the nozzle is configured to scatter the particle beam in a pattern that irradiates a plurality of strut edges simultaneously when the plurality of strut edges lie within a same section of a stent that is perpendicular to the longitudinal direction of the stent.5. A system for fabricating a stent claim 1 , the system comprising:a) a stent comprising a plurality of struts with strut edges lying within a same section that is perpendicular to the longitudinal direction of the stent; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'b) the device of .'}6. A method of fabricating a stent claim 1 , the method comprising:a) providing a stent comprising a plurality of struts with strut edges lying within a same section that is perpendicular to the longitudinal direction of the stent;{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'b) providing ...

LASER DIMPLED STENT FOR PREVENTION OF RESTENOSIS

A dimpled stent design has geometrical characteristics, namely dimple width and depth, which generate dimple site specific turbulence and thrust within the blood flow to reduce or eliminate restenosis. The dimpled stent design is produced by laser processing of the stent material to produce different sizes, which may be predicted by a Multiphysics computational model, placements, and spatial layouts of dimples in the stent. 5. The method of claim 1 , wherein the stent material is a titanium alloy claim 1 , cobalt-chrome alloy claim 1 , or stainless steel.6. The method of claim 1 , further comprising the step of choosing a laser to generate a laser beam claim 1 , wherein the laser is a Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAlO) laser.7. The method of claim 1 , further comprising the step of choosing a laser to generate a laser beam claim 1 , wherein the laser operates at a laser power of 500 W to 1800 W.8. The method of claim 1 , further comprising the step of using a Multiphysics computational model to predict and define features of the one or more dimples produced at the targeted surface areas.10. The method of claim 8 , wherein width and depth of the one or more dimples produced at the targeted surface areas are determined based on the Multiphysics computational model.11. The dimpled stent produced by the method of .12. A dimpled stent claim 1 , comprising:circumferential walls enclosing a cylindrical inner space surrounding a central axis, wherein the circumferential walls comprise one or more laser produced dimples protruding outwardly away from the central axis to create one or more dimpled spaces in outer edges of the cylindrical inner space.13. The dimpled stent of claim 12 , wherein the dimpled stent is about 30 mm long and about 3.5 mm in diameter claim 12 , wherein the circumferential walls are about 0.1 mm thick claim 12 , and wherein the dimples have a depth of about 0.12 mm and a width of about 0.6 mm.14. A dimpled stent claim 12 , comprising:a ...

MYOCYTE-DERIVED FLOW ASSIST DEVICE: EXTRAVASAL SHEATHS OF RHYTHMICALLY CONTRACTING MYOCYTES AIDING FLOW OF BIOLOGICAL FLUIDS

This invention relates, e.g., to a Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of a biological fluid, such as venous blood or lymph, comprising a sheath which comprises rhythmically contracting myocytes. 1. A Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of biological fluids , comprising;a vessel segment; anda sheath which comprises rhythmically contracting myocytes, the sheath disposed on at least a portion of a surface of the vessel segment,wherein the sheath further comprises at least one sheet of myocytes formed into a ring.2. The MFAD of claim 1 , wherein the sheath further comprises a scaffold claim 1 , within which are embedded the rhythmically contracting myocytes.3. The MFAD of claim 1 , wherein the myocytes are immunologically compatible with the subject.4. The MFAD of claim 2 , wherein the scaffold is of biological origin.5. The MFAD of claim 2 , wherein the scaffold is made of a chemical agent.6. The MFAD of claim 1 , wherein the sheath is in the form of at least one of:a thick sheet, having a thickness of about 0.2-5 mm; orone or more thin sheets, each individual sheet having a thickness of about 50-300 microns, providing a combined thickness of about 0.2-5 mm; ora mesh-like, woven, or prefabricated pattern of myocyte comprising fibers; ora coil-like arrangement of thick muscle fibers that results in a left-handed or right-handed helical arrangement or both; ora combination of helical fiber arrangements with circumferential fiber alignment.7. The MFAD of claim 1 , wherein the myocytes are cardiomyocytes.8. The MFAD of claim 1 , wherein the myocytes are smooth muscle cells.9. The MFAD of claim 1 , wherein the sheath comprises a section that comprises pacemaker-like cells while the rest of sheath comprises ventricular-like cells.10. The MFAD of claim 9 , whereinthe pacemaker-like section is in a form of a ring which abuts the section comprising the ventricular-like ...

MULTI-LAYER FOLDING FLOW DIVERTERS

A tubular, folding flow diverter is provided. The flow diverter includes a plurality of sections, including a first section, a second section, and a third section. The flow diverter is shapeable to an elongated cylindrical shape and is movable to an implanted configuration. In the implanted configuration, the second section and at least a portion of the first and third sections overlap to form a three-layer shape. This three-layer shape can be positioned proximate an aneurysm neck when implanted in a patient. The overall porosity of the implant can be higher than legacy implants, because the overlapping portion of the three sections can decrease the porosity proximate the aneurysm neck. 1. A vascular flow diverter , comprising:a first tubular section defining an inner lumen;a third tubular section positionable within the inner lumen; anda second tubular section disposed between the first tubular section and the third tubular section,wherein the vascular flow diverter is foldable from a delivery configuration to an implanted configuration,wherein, in the delivery configuration, the first tubular section, the second tubular section, and the third tubular section define a single-layer cylindrical shape, andwherein, in the implanted configuration, the second tubular section is overlapped by at least a portion of the first tubular section and the third tubular section, thereby creating a three-layer shape proximate the second tubular section.2. The vascular flow diverter of claim 1 , wherein the first tubular section claim 1 , the third tubular section claim 1 , and the second tubular section comprise a braided mesh comprising a porosity of from approximately 80% to approximately 90%.3. The vascular flow diverter of claim 2 , wherein three-layer shape proximate the second tubular section comprises a porosity of from approximately 50% to approximately 70%.4. The vascular flow diverter of claim 1 , wherein the second tubular section comprises a different porosity than the ...

Stent

A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.

PERFUSION REGULATION SYSTEM

A reperfusion system and method of perfusing a blood vessel using the reperfusion system are provided. The system includes an introducer sheath, a middle catheter extending through the introducer sheath, and a balloon microcatheter extending through the middle catheter. A connecting tube extends between a lumen of the introducer sheath and a valve at a proximal end of the microcatheter. A flow path is defined along a lumen of the introducer sheath, through the connecting tube, into the microcatheter, and out of a distal opening of the microcatheter. The balloon is disposed adjacent the exit point of the flow path to reduce reflux. Embolic material can be introduced into the microcatheter at the valve to exit at the same location as the blood flow. 1. A reperfusion catheter system comprising:an introducer sheath having a wall defining a longitudinal lumen extending from a proximal portion to a distal end;a middle catheter having a wall and having a longitudinal opening extending from a proximal portion to a distal end, the middle catheter disposed through the lumen of the introducer sheath;a microcatheter having a wall and having a longitudinal lumen extending from a proximal portion to a distal end, the microcatheter disposed through the lumen in the middle catheter, the microcatheter having an inflatable balloon on the distal end;a connecting tube having a first end disposed in fluid communication with the inside of the introducer sheath and a second end disposed in fluid communication with the microcatheter; andan antegrade blood flow path defined between an inner surface of the introducer sheath and an outer surface of the middle catheter, through the connecting tube, through the proximal portion of the microcatheter, through the lumen of the microcatheter, and exiting the distal end of the microcatheter.2. The system of further comprising a valve disposed between the proximal portion of the microcatheter and the connecting tube claim 1 , the valve having a first ...

ENDOVASCULAR PERFUSION STENT GRAFT

An endovascular perfusion stent graft is provided that can include a graft device, a balloon and a valve. The graft device can be inserted into a vessel. The balloon can be inserted into the graft device and can temporarily restrict passage of fluid or gas received via a perfusion port when the balloon is inflated via a bulb that provides air pressure to the balloon. The perfusion port can be operatively connected to another perfusion port configured to allow the fluid or the gas to pass through another balloon. The valve can be attached to the graft device. 1. A system , comprising:a graft device configured to be inserted into a vessel;a balloon configured to be inserted into the graft device and to temporarily restrict passage of fluid or gas received via a perfusion port when the balloon is inflated via a bulb that provides air pressure to the balloon, wherein the perfusion port is operatively connected to another perfusion port configured to allow the fluid or the gas to pass through another balloon; anda valve configured to be attached to an end of the graft device.2. The system of claim 1 , wherein the valve is configured to be attached at a distal end of the graft device.3. The system of claim 1 , wherein the valve is configured to open and close to provide unidirectional flow of the fluid or the gas.4. The system of claim 1 , wherein the valve is selectively removable from the graft device.5. The system of claim 1 , wherein the valve is a wire mesh valve attached to the end of the graft device.6. The system of claim 1 , wherein the valve is a mechanical valve attached to the end of the graft device.7. The system of claim 1 , wherein the valve is a bioprosthetic valve attached to the end of the graft device.8. The system of claim 1 , wherein the bulb is configured to provide the air pressure to the balloon through a balloon infusion port.9. The system of claim 1 , further comprising:another graft device configured to be inserted into another vessel, wherein ...

Treatment of tricuspid insufficiency

A tricuspid insufficiency treatment device includes a vena cava member ( 12 ) implantable in a vena cava of a patient. The vena cava member ( 12 ) is formed with a fenestration ( 14 ) and further includes a blocking member ( 16 ) arranged to block and unblock the fenestration ( 14 ).

FLOW-DIVERTING IMPLANT AND DELIVERY METHOD

A flow-diverting implant includes a saddle-shaped braided mesh diverter that is sized to provide adequate blocking coverage of a neck of an aneurysm. The diverter is anchored using minimally profiled, generally circular anchors that present little to no resistance to blood flow and are unlikely to create thrombosis. A locator extends into the aneurysm to ensure the diverter is optimally positioned over the neck of the aneurysm. 1. A flow diverting implant comprising:a flow diverter;a first anchor positioned at a proximal portion of the flow diverter;a second anchor positioned at a distal portion of the flow diverter; anda locator unit;the locator unit configured such that when in a deployed state for reception in the aneurysm, the flow diverter is in a diverting state and the first and second anchors are in an anchoring state.2. The flow diverting implant of claim 1 , wherein the flow diverter is a single layer mesh structure.3. The flow diverting implant of claim 1 , wherein the flow diverter is woven from a single wire.4. The flow diverting implant of claim 1 , wherein the flow diverter comprises pores having sizes in a range of about 10-20 pores/mm.5. The flow diverting implant of claim 1 , wherein the flow diverter is slightly larger than the neck of the aneurysm.6. The flow diverting implant of claim 1 , wherein the flow diverter comprises a shape of a saddle7. The flow diverting implant of claim 1 , wherein the flow diverter has a rounded distal portion.8. The flow diverting implant of claim 1 , wherein the flow diverter has a semicircular proximal portion culminating in two tapered corners.9. A flow diversion system comprising: a proximal end and a distal end;', 'a heating element proximal the distal end;', 'a power source connected to the heating element with a switch;', 'an activation mechanism near the proximal end that closes the switch; an implant comprising:', 'a flow diverter having a proximal end;', 'at least one anchor attached to the flow diverter; ...

FLOW MODIFICATION DEVICES IN BODY LUMENS

The devices and methods described herein include a body lumen fluid flow modulator including an upstream flow accelerator and a downstream flow decelerator. The fluid flow modulator preferably includes one or more openings that define a gap/entrainment region that provides a pathway through which additional fluid from a branch lumen(s) is entrained into the fluid stream flowing from the upstream flow accelerator to the downstream flow decelerator. 1. A device for altering fluid flow through a body lumen , the body lumen coupled to a branch lumen , the device comprising:a flow modulator configured to be positioned within the body lumen, the flow modulator comprising an upstream component, a downstream component, and an entrainment region, the upstream component having an inlet, an outlet, and a cross-sectional flow area that converges from the inlet towards the outlet, the downstream component having an entry, an exit, and a cross-sectional flow area that diverges from the entry towards the exit, and the entrainment region comprising a plurality of longitudinally extending openings radially spaced around the entrainment region, the entrainment region between the inlet of the upstream component and the exit of the downstream component,wherein the flow modulator is configured to accelerate a fluid stream passing through the upstream component towards the downstream component to generate a low pressure region in the vicinity of the entrainment region that entrains additional fluid into the fluid stream via the plurality of longitudinally extending openings as the fluid stream passes into the entry of the downstream component.2. The device of claim 1 , wherein the entrainment region diverges at a same angle as at least a portion of the downstream component's divergence angle.3. The device of claim 1 , wherein the entrainment region is integrally formed with the downstream component.4. The device of claim 1 , wherein the entry of the downstream component has a diameter ...

METHOD AND APPARATUS FOR STENTING

A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. 160-. (canceled)61. A unitary stent for implantation in a vascular lumen , wherein , in an expanded state of the stent , the stent having a longitudinal axis along a direction of blood flow and an envelope , said envelope comprising:a first end and a second end defining a length therebetween, said envelope consisting of an asymmetric shape over the entire length;a bottom portion of the envelope shaped of a right cylinder cut in half; andan upper portion of the envelope asymmetrical to the bottom portion, said upper portion comprising a taper at a constant angle to the longitudinal axis of the stent along the entire length of the envelope.62. The stent of claim 61 , wherein the stent is a self-expanding stent.63. A unitary stent for implantation in a vascular lumen claim 61 , wherein claim 61 , in an expanded state of the stent claim 61 , said stent having a length and an asymmetric shape over the entire length claim 61 , said stent comprises a longitudinal axis along a direction of blood flow and a plurality of cross-sections at planes perpendicular to the longitudinal axis claim 61 , each cross-section having a shape claim 61 ,wherein at least one of said cross-sections is non-uniformly circular about the longitudinal axis and at least two of the plurality of cross-sections have different shapes from one another.64. The stent of claim 63 , wherein the stent is a self-expanding stent.65. The stent of claim 63 , wherein all cross-sections are non-uniformly circular about the longitudinal axis.66. The stent of claim 63 , further comprising a first end and a second end separated by the length claim 63 , wherein a first cross-section taken at the first end has a larger area than a second cross-section taken at the second end. The present ...

METHOD AND APPARATUS FOR STENTING

A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. 160-. (canceled)61. An expandable medical device for implantation in a body , the device having an envelope and a longitudinal axis along a direction of blood flow , the device comprising:a first device segment;a second device segment; anda third device segment,wherein the first device segment is longitudinally separated from the third device segment, the first device segment directly connected around the circumference to the second device segment, the third device segment directly connected around the circumference to the second device segment,wherein the first device segment has a tapered configuration in an expanded state of the device, the second device segment has a tapered configuration in an expanded state of the device, and the third device segment has a tapered configuration in an expanded state of the device,wherein the second device segment diverges from the tapered configuration of the first device segment, and the third device segment diverges from the tapered configuration of the second device segment.62. The expandable medical device of claim 61 , wherein the first device segment comprises an opening having a first diameter and the third device segment comprises an opening having a second diameter.63. The expandable medical device of claim 62 , wherein the first diameter and the second diameter are the same.64. The expandable medical device of claim 62 , wherein the first diameter is larger than the second diameter.65. The expandable medical device of claim 61 , wherein the largest cross-sectional areas of the first device segment and the second device segment are different.66. The expandable medical device of claim 61 , wherein the device is self-expanding.67. The expandable medical device of claim 61 , wherein the device is ...

MEDICAL DEVICE, IN PARTICULAR A FLOW DIVERTER, AND KIT

The invention concerns a medical device, in particular a flow diverter, having a radially self-expandable lattice structure () which is tubular at least in some regions and which is composed of a plurality of interwoven individual wires () which form meshes () of the lattice structure (), wherein at least some of the individual wires () have an X-ray visible core material () and a superelastic mantle material (), wherein a plurality of directly adjacent meshes () in the circumferential direction of the lattice structure () form a mesh ring (), wherein in a fully self-expanded state, the lattice structure () has an expansion diameter D, the mesh ring () has a mesh number n, and the core material () has a core diameter d, and wherein for the core diameter d, the following holds: 2. The medical device as claimed in claim 1 ,characterized in that{'sub': 'exp', '#text': 'the expansion diameter Dis 2.5 mm to 8 mm.'}3. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': '10', '#text': 'a braiding angle α of the lattice structure () is between 70° and 80°, in particular 75°.'}4. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': '11', 'sub': 'wire', 'claim-text': [{'sub': ['exp', 'wire'], '#text': 'in the case of an expansion diameter Dof 2.5 mm to 4.5 mm: 30 μm≤d≤46 μm, and'}, {'sub': ['exp', 'wire'], '#text': 'in the case of an expansion diameter Dof more than 4.5 mm to 8 mm: 46 μm≤d≤65 μm.'}], '#text': 'the wire () has a wire diameter d, which is'}5. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': '11', 'i': 'b', '#text': 'the mantle material () of the wire has a thickness which is at least 10 μm, in particular at least 15 μm, in particular 10 μm to 20 μm.'}6. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': ['11', '11'], 'i': 'a', '#text': 'the volume of the core material () takes up a ...

STENT APPARATUS AND TREATMENT METHODS

An apparatus including a plurality of stents is provided, each stent having a centre line curving in three dimensions. The plurality of stents includes at least one stent with a centre line having a right handed curvature and at least one stent with a centre line having a left handed curvature. 1. Apparatus comprising a plurality of stents each having a centre line curving in three dimensions , the plurality of stents including at least one stent with a centre line having right-handed curvature and at least one stent with a centre line having left-handed curvature.2. Apparatus as claimed in claim 1 , comprising a plurality of right-handed curved stents and a plurality of left-handed curved stents.320-. (canceled)21. Apparatus as claimed in claim 1 , wherein the stents comprise a shape memory material.22. Apparatus as claimed in claim 1 , wherein the stents comprise a plastically deformable material.23. Apparatus as claimed in claim 1 , wherein the stents are balloon expandable.24. Apparatus as claimed in claim 2 , wherein the plurality of right-handed curved stents are all the same size.25. Apparatus as claimed in claim 2 , wherein the plurality of right-handed curved stents comprise stents with different size diameters and/or lengths.26. Apparatus as claimed in claim 2 , wherein the plurality of left-handed curved stents are all the same size.27. Apparatus as claimed in claim 2 , wherein the plurality of left-handed curved stents comprise stents with different size diameters and/or lengths.28. Apparatus as claimed in claim 1 , wherein each of the plurality of stents has a centre line that is helical. The invention relates to a stent apparatus and to a method of treating hypoxia in vascular tissue, and to treatment and stenting methods of subjects with diabetes mellitus.Blood vessel walls are comprised of living cells which are metabolically active and therefore require a supply of nutrients including oxygen. In the absence of disease, cells in blood vessel walls ...

Vascular prosthesis for treating aneurysms

Apparatus for use with a delivery catheter, including a primary stent-graft and a flared endovascular stent-graft, which is configured to initially be positioned in the delivery catheter in a radially-compressed state, and to assume a radially-expanded state upon being deployed from the delivery catheter. The primary stent-graft includes (a) a structural member, which includes a plurality of structural stent elements, and which, when the flared endovascular stent-graft assumes the radially-expanded state, is shaped so as to define a flared caudal portion, which flares radially outward in a caudal direction; (b) at least one biologically-compatible substantially fluid-impervious flexible sheet, which is coupled to at least the flared caudal portion; and (c) a stent-engagement member, which is generally tubular when the flared endovascular stent-graft assumes the radially-expanded state, which is disposed at least partially within the flared caudal portion, and which is configured to be sealingly coupled to the primary stent-graft.

Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment success

Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In at least one exemplary embodiment of an endograft body configured for expansion within a luminal organ of the present disclosure, the endograft body comprises (a) a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion configured to increase a velocity of fluid flowing therethrough, (b) a second portion having a second portion proximal end defining a second portion proximal end aperture and a second portion distal end defining a second portion distal end aperture.

Methods, systems, and devices for relieving congestion of the lymphatic system

Systems, devices and methods for treating lymphatic congestion are disclosed. In one method, a balloon is placed at or near the veno-lymph junction. The balloon is inflated and deflation through cycles of slow inflation and rapid deflation. In another embodiment, an arteriovenous fistula is created near the veno-lymph junction. Alternate embodiments may also include axial pumps, stents, or balloons in combination with the fistula. These devices and methods create an acceleration of the blood flow past the lymphatic duct which reduces local pressure via the Venturi effect and according to the Bernoulli principle which facilitates lymph entering into the bloodstream.

Magnetically Activated Arteriovenous Access Valve System and Related Methods

In one aspect, an arteriovenous access valve system may generally include a first valve configured to be positioned at or adjacent to an end of arteriovenous graft and a second valve configured to be positioned at or adjacent to an opposite end of the arteriovenous graft. In addition, the system may include an actuator assembly in fluid communication with the first and second valves. The actuator assembly may include a housing, a driver assembly positioned within the housing and a drive magnet positioned within the housing. The drive magnet may be rotatably coupled to the driver assembly such that, when the drive magnet is rotated, the driver assembly is configured to be rotatably driven so as to supply fluid to the first and second valves or to draw fluid out of the first and second valves depending on a rotational direction of the driver assembly.

METHOD AND APPARATUS FOR STENTING

A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. 1. An expandable medical device for implantation in a body having a longitudinal axis along a direction of blood flow , said device comprising a first device segment directly connected around the circumference to a second device segment , said device having two tapers wherein the first device segment has a diverging configuration and the second device segment has a converging configuration.2. The expandable medical device of claim 1 , wherein the first device segment has an opening having a first diameter and the second device segment has an opening having a second diameter.3. The expandable medical device of claim 2 , wherein the first diameter and the second diameter are the same.4. The expandable medical device of claim 2 , wherein the first diameter is larger than the second diameter.5. The expandable medical device of claim 1 , wherein the device is self-expanding.6. The expandable medical device of claim 1 , wherein the device is balloon-expandable.7. The expandable medical device of claim 1 , wherein a cross-section of any device segment in a plane normal to the longitudinal axis thereof is circular.8. The expandable medical device of claim 1 , further comprising a means for controlling a flow of blood.9. The expandable medical device of claim 1 , wherein the device is configured to minimize a flow disturbance in the body.10. The expandable medical device of claim 5 , wherein the device is re-positionable after delivery.11. The expandable medical device of claim 1 , wherein the device is a stent structurally configured for implantation in a lumen of a blood vessel.12. The expandable medical device of claim 1 , wherein the device further comprises a first straight section located at a first end of the device.13. The expandable medical ...

IMPLANTABLE CARDIO-VASCULAR FLOW STREAMLINER

Embodiments herein provide an implantable Flow Streamliner for passively regulating blood streams in a TCPC subject. The implantable Flow Streamliner is configured to split a blood stream from an Inferior Vena Cava (IVC) and a blood stream from a Superior Vena Cava (SVC), without a direct collision between the blood streams. Further, the implantable Flow Streamliner is configured to distribute the blood stream from the IVC containing hepatic nutrients in proportion to a Left Pulmonary Artery (LPA) and a Right Pulmonary Artery (RPA). Further, the implantable Flow Streamliner is configured to distribute the blood stream from the SVC in equal proportion to the LPA and the RPA. 1. An implantable Flow Streamliner for passively regulating blood streams in a Total Cavo-Pulmonary Connection (TCPC) subject , the implantable Flow Streamliner is configured to:split a blood stream from an Inferior Vena Cava (IVC) and a blood stream from a Superior Vena Cava (SVC), and enable their confluence without a collision between the blood streams;distribute the blood stream from the IVC, containing hepatic nutrients, in proportion to a Left Pulmonary Artery (LPA) and a Right Pulmonary Artery (RPA); anddistribute the blood stream from the SVC in proportion to the LPA and the RPA.2. The implantable Flow Streamliner of claim 1 , wherein the implantable Flow Streamliner is a cardio-vascular Flow Streamliner.3. The implantable Flow Streamliner of claim 1 , wherein the blood stream from the IVC claim 1 , containing the hepatic nutrients claim 1 , is regulated in proportion to the LPA and the RPA without constraint.4. The implantable Flow Streamliner of claim 1 , wherein the blood stream from the SVC is regulated in proportion to the LPA and the RPA without constraint.5. The implantable Flow Streamliner of claim 1 , wherein the implantable Flow Streamliner is configured to enable confluence of the blood streams from the SVC and the IVC to the RPA and the LPA.6. The implantable Flow Streamliner ...

Stent-graft

A stent-graft comprises: a graft defining an elongate lumen having a longitudinal axis; an external stent having a plurality of struts and apices between the struts, the apices including proximal apices and distal apices; a set of proximal sutured knots, the proximal sutured knots securing the proximal apices of the stent to the graft; a set of distal sutured knots, the distal sutured knots securing the distal apices of the stent to the graft; and a plurality of intermediate sutured knots, formed along a continuous suture, the continuous suture including a plurality of bridging portions, the bridging portions bridging between neighbouring struts of the stent, the intermediate sutured knots securing struts of the stent to the graft.

MODULAR ENDO-AORTIC DEVICE FOR ENDOVASCULAR AORTIC REPAIR OF DISSECTIONS AND BEING CONFIGURED FOR ADAPTABILITY OF ORGANS OF VARIOUS ANATOMICAL CHARACTERISTICS AND METHOD OF USING THE SAME

A device for placement in the aortic arch of a patient is provided. The device includes a distal portion for being engageably received in an aortic arch of a patient beyond the left subclavian artery and a stent portion fluidly engaged with the distal portion, the stent portion being permeable and configured to span a portion of the aortic arches to which the brachiocephalic trunk, left common carotid artery, and left subclavian artery attach to the aortic arch. A diameter of the stent portion may be modified by translation of the proximal portion to thereby alter a length of the stent portion thus causing modification of the diameter of the stent portion to fit anatomical features of differing dimensions. 1. A kit comprising:a stent device for placement in the aorta of a patient, wherein a diameter of the stent device may be modified by translation of an end of the stent device to thereby alter a length thereof causing modification of the diameter of the stent device; anda deployment apparatus for housing the stent device and having a guide rod passing through a center therethrough for deploying the stent device at an operational site, the deployment apparatus constraining the stent in a compressed state controlling an end of the stent device and by translating along an axis of the deployment apparatus and the guide rod carrying the stent device and being removable through a center of the stent when the stent is in an expanded state upon actuation of the deployment apparatus.2. The kit of claim 1 , wherein the stent device includes at least one eyelet on a first end facing an operator claim 1 , and the deployment apparatus is configured to engage the eyelet to expand and contract the end of the stent device to thereby shorten and elongate the stent device claim 1 , the deployment apparatus being configured to release the stent device when a desired diameter of the stent device is reached.3. The kit of claim 2 , wherein the deployment apparatus is initially ...

Aortic pressure loss reduction apparatus and methods

Apparatus and methods are described including implanting an aortic pressure-loss-reduction device in a subject's ascending aorta. While the device is inside a catheter, a distal end of the catheter is placed within the ascending aorta. A proximal covering sheath of the catheter is retracted such as to uncover at least a portion of a downstream anchor, such that the uncovered portion of the downstream anchor includes a portion of the frame that does not have material coupled thereto. Subsequently, a distal covering sheath of the catheter is advanced, such as to cause an upstream anchor to anchor an upstream end device to the subject's ascending aorta, by the upstream anchor radially expanding against an inner wall of the ascending aorta. Other applications are also described.

MODULAR MULTIBRANCH STENT ASSEMBLY AND METHOD

The techniques of this disclosure generally relate to an assembly including a single branch stent device and a modular stent device configured to be coupled to the single branch stent device. The single branch stent device includes a main body and a branch coupling extending radially from the main body. The modular stent device includes a main body configured to be coupled inside of the main body of the single branch stent device, a bypass gate extending distally from a distal end of the main body of the modular stent device, and an artery leg extending distally from the distal end of the main body of the modular stent device. 1. An assembly comprising: a main body; and', 'a branch coupling extending radially from the main body; and, 'a single branch stent device comprising a main body configured to be coupled inside of the main body of the single branch stent device;', 'a bypass gate extending distally from a distal end of the main body of the modular stent device; and', 'an artery leg extending distally from the distal end of the main body of the modular stent device., 'a modular stent device configured to be coupled to the single branch stent device, the modular stent device comprising2. The assembly of wherein the artery leg has a greater radial force than a radial force of the bypass gate.3. The assembly of wherein the main body of the modular stent device has a first longitudinal axis claim 1 , the bypass gate has a second longitudinal axis claim 1 , and the artery leg has a third longitudinal axis claim 1 , the first claim 1 , second claim 1 , and third longitudinal axes are parallel with one another when the modular stent device is in a relaxed configuration.4. The assembly of wherein a length of the artery leg is greater than a length of the bypass gate.5. The assembly of wherein the length of the artery leg is measured along the third longitudinal axis claim 4 , and the length of the bypass gate is measured along the second longitudinal axis.6. The ...

Accessory device to provide neuroprotection during interventional procedures

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

TRANSCATHETER MITRAL VALVE

Transcatheter stent valve implants and implants that preserve functional caliber of the left ventricle outflow tract, LVOT, and streamlined blood flow from left ventricular inflow to the LVOT. The implants have inflatable balloons that prevent regurgitation around the device and allow more accurate sizing and fit. 1. A cardiac stent valve implant comprising:a stent body having a first end and a second end;a prosthetic valve assembly coupled to an interior surface of the stent body closer to the first end than to the second end;a first set of anchoring arms coupled to the first end of the stent body; anda second set of anchoring arms coupled to the second end of the stent body, wherein at least one of the stent body, the first set of anchoring arms, or the second set of anchoring arms are configured such that upon implantation of the device within a native heart valve annulus, at least a portion of the stent body is oriented at an angle with respect to an axis normal to a plane of a native heart valve annulus.2. The device of claim 1 , wherein the anchors of at least one of the first set of anchors or the second set of anchors are arranged asymmetrically about a circumference of at least one end of the cardiac stent valve implant claim 1 , resulting in an angled orientation of at least a portion of the stent body with respect to the axis normal to the plane of the native heart valve annulus.3. The device of claim 2 , wherein the asymmetrically arranged anchors have variation in length about the circumference of at least one end of the cardiac stent valve implant claim 2 , resulting in an angled orientation of at least a portion of the stent body with respect to the axis normal to the plane of the native heart valve annulus.4. The device of claim 1 , wherein the stent body between the first and second ends has a straight longitudinal axis.5. The device of claim 1 , wherein the stent body has a longitudinal axis that is defined by a curved or bent line claim 1 , ...

TETHERED IMPLANTABLE DEVICE HAVING AN APICAL BASE PLATE WITH A HYDRAULIC INTRACARDIAC ADJUSTING MECHANISM

An implant system for restoring and improving physiological intracardiac flow in a human heart is provided including an implant for positioning at least partially within a human heart; an apical base plate assembly attachable to the apex of the heart; a tether assembly comprising a tether connected between the implant and the therapeutic apical base plate assembly, and an adjustment assembly connected to the tether assembly to permit longitudinal movement of the tether assembly and implant relative to the base plate assembly. 170-. (canceled)71. An implant system for improving intracardiac blood flow , the implant system comprising:a shaft comprising a proximal end, a distal end, and a conduit therethrough;a flow-vectoring member coupled to the distal end of the shaft, the flow vectoring member comprising an inflatable paddle disposed at a distal-most end of the member, wherein the flow-vectoring member comprises a chamber for receiving an inflating fluid;an adjustment assembly coupled between the proximal end and the distal end of the shaft, the adjustment assembly proximal to the flow vectoring inflatable balloon;an apical base plate assembly having a base coupled to the adjustment assembly;a tube comprising a plurality of lumens, a proximal end, and a distal end, the tube coupled proximal to the distal end to the apical base plate assembly; anda control unit coupled to the proximal end of the tube and in fluid communication with the plurality of lumens.72. The implant system of claim 71 , further comprising a fluid disposed within the flow-vectoring member claim 71 , the shaft claim 71 , the tube claim 71 , and the control unit.73. The implant system of claim 71 , further comprising crescent beam disposed at a distal end of the flow-vectoring member claim 71 , a first side wing having a crescent-shaped articulation claim 71 , a second side wing having a crescent-shaped articulation claim 71 , and a truss extending from the crescent beam to the shaft.74. The ...

Vascular implant

A medical implant ( 20 ) includes first and second ring members ( 22, 24 ), each including a resilient framework ( 26 ) having a generally cylindrical form. A tubular sleeve ( 28 ) is fixed to the first and second ring members so as to hold the ring members in mutual longitudinal alignment, thereby defining a lumen ( 32 ) passing through the ring members. A constricting element ( 30 ) is fit around the sleeve at a location intermediate the first and second ring members so as to reduce a diameter of the lumen at the location.

Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina

Methods of treating coronary artery disease (CAD) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed. 1. A method of treating coronary artery disease (CAD) in a patient in need thereof comprising:selecting a patient in need of treatment of CAD having a lesion in a blood vessel that is an indicator of high risk or a susceptibility of the patient to angina or non-ischemic thoracic chest pain; andimplanting a bioresorbable stent at the lesion in a blood vessel of the patient, wherein the implanted scaffold treats the CAD.2. The method of claim 1 , wherein the lesion is a long diffuse lesion having a length of at least 20 mm.3. The method of claim 1 , wherein the stent is a bioresorbable polymer stent.4. The method of claim 1 , wherein the lesion is an ostial lesion.5. The method of claim 4 , wherein the ostial lesion begins within Ito 5 mm of an origin of a major epicardial artery.6. The method of claim 1 , wherein the lesion is a vulnerable plaque suspect lesion.7. The method of claim 6 , wherein the lesion has less than 50% occlusion as shown by angiography.8. The method of claim 1 , wherein the lesion is a bifurcated lesion9. The method of claim 1 , wherein the patient experiences no angina or non-ischemic thoracic chest pain for at least 1 year after implantation.10. The method of claim 1 , wherein the susceptibility comprises a history of angina of the patient within one year prior to implantation.11. The method of claim 1 , wherein the susceptibility comprises a % diameter stenosis of greater than 70% at a site of implantation of the stent.12. A method of treating coronary artery disease (CAD) in a patient or population of patients comprising:recommending treatment or describing advantages relating to reduced angina of bioresorbable polymer stents or a type ...

Stent

A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.

CEREBRAL BLOOD FLOW REORGANIZATION

An implantable device includes an outer tubular member defining a longitudinal axis and a lumen. The outer tubular member includes: an outer wall portion having a plurality of first strands defining a plurality of first openings therebetween, the outer wall portion having a first porosity; and an inner baffle portion disposed within the lumen, the inner baffle portion including a plurality of second strands defining a plurality of second openings therebetween, the inner baffle portion having a second porosity that is lower than the first porosity of the outer wall portion. 1. An implantable device comprising: an outer wall portion having a plurality of first strands defining a plurality of first openings therebetween, the outer wall portion having a first porosity; and', 'an inner baffle portion disposed within the lumen, the inner baffle portion including a plurality of second strands defining a plurality of second openings therebetween, the inner baffle portion having a second porosity that is lower than the first porosity of the outer wall portion., 'an outer tubular member defining a longitudinal axis and a lumen, the outer tubular member including2. The implantable device according to claim 1 , wherein the inner baffle portion includes a planar surface.3. The implantable device according to claim 1 , wherein the inner baffle portion includes an inner tubular member.4. The implantable device according to claim 3 , wherein the inner tubular member of the inner baffle portion is eccentric relative to the outer tubular member.5. The implantable device according to claim 4 , further comprising a wire coupled to the inner tubular member claim 4 , wherein movement of the wire adjusts the second porosity of the inner baffle member.6. The implantable device according to claim 1 , wherein at least one of the first porosity and the second porosity are adjustable.7. A method for treating pulsatile tinnitus claim 1 , the method comprising:imaging cerebral blood vessels ...

DEVICES AND METHODS FOR RESHAPING BLOOD VESSELS

Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction. 1. A method for reshaping a native vein to make the vein prone to bending or compression in response to an external force , said method comprising:implanting an elongate member across a generally circular lumen of the vein, wherein a central region of the lumen has a diameter when the vein is unconstrained;wherein the implant compresses opposed walls of the vein such that a length across the central region is reduced to less than the diameter of the unconstrained vein but blood flow in not blocked; andwherein the compressed shape makes the vein more prone to external forces which cause a decrease or temporarily stoppage of blood flow through the vein.2. A method as in claim 1 , wherein the lumen of the vein assumes an ovoid or rectangular shape when compressed by the implant.3. A method as in claim 1 , wherein implanting the elongate member comprises:penetrating a distal end of the implant inwardly through an entry location in a wall of the vein and outwardly through an exit location on an opposed wall of the vein,deploying a distal anchor of the implant on an exterior surface of the opposed wall adjacent to the distal location;drawing proximally on the implant to partially collapse the lumen of the vein; anddeploying a proximal anchor of the implant on an exterior surface of the opposed wall to maintain the partial collapse of the lumen of the vein.4. A method as in claim 3 , wherein the implant consists of a single wire having a coiled distal anchor and a coiled proximal anchor formed ...

DEVICE AND METHOD FOR INCREASING FLOW THROUGH THE LEFT ATRIAL APPENDAGE

Methods and devices for increasing flow in the left atrial appendage (LAA) include a conduit directing blood flow from a pulmonary artery into the LAA and/or a conduit drawing blood from the LAA by a Bernoulli effect. In one embodiment, a method comprises implanting a conduit in a pulmonary vein, expanding an inlet portion such that the conduit becomes anchored within the vein and directs blood through an outlet portion of the conduit into or toward the left atrial appendage. 1. A method of implanting a prosthetic conduit in a heart , comprising:inserting a distal end portion of a delivery catheter into a left atrium of the heart, the prosthetic conduit being carried in a radially compressed or collapsed state by the distal end portion of the delivery catheter;expanding an inlet portion of the prosthetic conduit in a left atrial appendage such that the inlet portion of the prosthetic conduit becomes anchored within the left atrial appendage and directs blood in the left atrial appendage to flow through a lumen of the prosthetic conduit and outwardly through an outlet portion of the prosthetic conduit; andlocating the outlet portion such that a flow of blood from the outlet portion is directed to flow in a direction toward a mitral valve.2. The method of claim 1 , wherein the flow of blood through the prosthetic conduit is induced by a Bernoulli-type effect at the outlet portion of the prosthetic conduit.3. A method of implanting a conduit in a heart claim 1 , comprising:anchoring an inlet portion of the conduit within a left atrial appendage such that the conduit extends from the left atrial appendage into a left atrium and directs a flow of blood from the left atrial appendage through a lumen of the conduit and outwardly through an outlet portion of the conduit in a direction toward the left atrium. The present invention relates to devices and methods for increasing flow through the left atrial appendage of the human heart, thereby helping to protect against flow ...

MONOLITHIC MEDICAL DEVICES, METHODS OF MAKING AND USING THE SAME

The monolithic device comprises a plurality of scaffolding members and a mesh patterned members webbed between the scaffolding members; the mesh patterned member webbed between the scaffolding members surround a lumen and generally expands from a contracted state to an expanded state; and mesh patterned members including a plurality of openings traversing the thickness of the mesh patterned member, and the mesh patterned members including a surface on which a pattern of openings is formed. 1. A monolithic device comprising:a stent cell pattern with a plurality of structural members configured to divert a majority of a fluid flow through the monolithic device without fully restricting the fluid flow wherein the stent cell pattern further comprises:a plurality of Z-pattern members, wherein the Z-pattern members include a plurality of peaks and a plurality of troughs along a longitudinal axis of the device, andwherein a first Z-pattern member and a second Z-pattern member positioned adjacent to the first Z-pattern member are interconnected by a plurality of interconnecting members.2. The monolithic device of claim 1 , further comprising:an end ring member including an end Z-pattern having a plurality of peaks and a plurality of troughs.3. The monolithic device of claim 1 , wherein the peaks of the end Z-pattern connect to every third trough of a Z-pattern member positioned adjacent to the end Z-pattern.4. The monolithic device of claim 1 , wherein spacing between adjacent interconnecting members is between about 0.1 and 20 microns when the monolithic device is in a deployed state.5. The device of claim 1 , wherein the monolithic device has a wall thickness between about 0.1 and about 100 microns claim 1 , and wherein the monolithic device is configured to have:a crimped state wherein the monolithic device has a diameter between about 0.2 and about 2.0 mm, andan expanded state wherein the monolithic device has a diameter between about 2.0 and about 7.0 mm.6. The ...

COMPOSITE VASCULAR FLOW DIVERTER

A vascular flow diverter includes a tubular mesh framework which includes a mesh cover and an opening. The tubular mesh framework is collapsible and configured to expand from a collapsed shape to a tubular shape when the vascular flow diverter is deployed. The mesh cover conforms to the shape of the tubular mesh, is surrounded by the tubular mesh framework, and is less porous than the tubular mesh framework. The opening is located within the mesh cover. A delivery wire passes through the opening in order to guide the flow diverter into place over an aneurysm. 1. A vascular flow diverter comprising:a tubular mesh framework configured to transition from a collapsed configuration to an expanded configuration in response to the vascular flow diverter being deployed, the tubular mesh framework having a first porosity; anda mesh cover surrounded by the tubular mesh framework and comprising an opening sized to allow a guide member to extend through the opening, the mesh cover configured to conform to a shape of the tubular mesh framework, the mesh cover having a second porosity, the first porosity being greater than the second porosity.2. The vascular flow diverter of claim 1 , wherein the mesh cover has a rounded perimeter.3. The vascular flow diverter of claim 1 , wherein the mesh cover has a circular perimeter.4. The vascular flow diverter of claim 1 , wherein the mesh cover is integrated with the tubular mesh framework.5. The vascular flow diverter of claim 1 , wherein the mesh cover is separate from and attached to the tubular mesh framework.6. The vascular flow diverter of claim 1 , wherein the mesh cover is attached to the tubular mesh framework by welding.7. The vascular flow diverter of claim 1 , wherein the mesh cover is attached to the tubular mesh framework by interlacing mesh strands of the mesh cover with mesh strands of the tubular mesh framework.8. The vascular flow diverter of claim 1 , wherein the tubular mesh framework transitions from the collapsed ...

MYOCYTE-DERIVED FLOW ASSIST DEVICE: EXTRAVASAL SHEATHS OF RHYTHMICALLY CONTRACTING MYOCYTES AIDING FLOW OF BIOLOGICAL FLUIDS

This invention relates, e.g., to a Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of a biological fluid, such as venous blood or lymph, comprising a sheath which comprises rhythmically contracting myocytes. 1. A Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of biological fluids , comprising a sheath which comprises rhythmically contracting myocytes.2. The MFAD of claim 1 , wherein the sheath further comprises a scaffold claim 1 , within which are embedded the rhythmically contracting myocytes.3. The MFAD of claim 1 , wherein the myocytes are immunologically compatible with the subject.4. The MFAD of claim 2 , wherein the scaffold is of biological origin.5. The MFAD of claim 2 , wherein the scaffold is made of a chemical agent.6. The MFAD of claim 1 , wherein the sheath is in the form ofa) a thick sheet, having a thickness of about 0.2-5 mm; orb) one or more thin sheets, each individual sheet having a thickness of about 50-300 microns, providing a combined thickness of about 0.2-5 mm; orc) a mesh-like, woven, or prefabricated pattern of myocyte comprising fibers; ord) a coil-like arrangement of thick muscle fibers that results in a left-handed or right-handed helical arrangement or both; ore) a combination of helical fiber arrangements with circumferential fiber alignments; orf) a combination of two or more of the forms of MFAD of a)-e).7. The MFAD of claim 1 , wherein the myocytes are cardiomyocytes.8. The MFAD of claim 1 , wherein the myocytes are smooth muscle cells.9. The MFAD of claim 1 , wherein the sheath comprises a section that comprises pacemaker-like cells while the rest of sheath comprises ventricular-like cells.10. The MFAD of claim 9 , wherein(a) the pacemaker-like section is in a form of a ring which abuts the section comprising the ventricular-like cells, or(b) the pacemaker-like section is a distal portion of a fiber that is coiled around the vessel.11. The MFAD of ...

SIDE-DELIVERED TRANSCATHETER HEART VALVE REPLACEMENT

The invention relates to a transcatheter heart valve replacement (A61F2/2412), and in particular to a side delivered large diameter, low profile transcatheter prosthetic valve having a compressible tubular frame having a side wall and a central axial lumen, said tubular frame having a height of 8-20 mm and a diameter of 40-80 mm, an atrial sealing cuff, a subannular anchoring component, and aa flow control component comprising a leaflet structure, wherein the valve is side-delivered longitudinally to a mitral valve annulus or tricuspid valve annulus of a patient using a 22-34 Fr delivery catheter. 1. A side-delivered transcatheter prosthetic valve comprising:a compressible tubular frame having a side wall and a central axial lumen, said tubular frame having a height of 8-20 mm and a diameter of 40-80 mm,an atrial sealing cuff attached to a top edge of the side wall,a subannular anchoring component attached to the tubular frame, said subannular anchoring component selected from one or more of the group consisting of a lower tension arm extending from a distal side of the tubular frame, a proximal anchoring tab extending from a proximal side of the tubular frame, a ventricular sealing collar attached to a bottom edge of the side wall, and at least one tissue anchor to connect the tubular frame to native tissue, anda flow control component comprising a leaflet structure having three leaflets of pericardial material sewn to a leaflet frame to form a rounded cylinder mounted within the lumen of the tubular frame and configured to permit blood flow in a first direction through an inflow end of the valve and block blood flow in a second direction, opposite the first direction, through an outflow end of the valve,wherein the valve is compressible to a compressed configuration for introduction into the body using a delivery catheter for implanting at a mitral valve annulus or tricuspid valve annulus of a patient, said delivery catheter having an internal diameter from 22 Fr ...

Blood pump

Apparatus and methods are described including a catheter ( 20 ), a first pump ( 24 U) disposed on the catheter, and a second pump ( 24 D) disposed on the catheter, proximally to the first pump. A control unit ( 52 ) is configured to control activation of the first and second pumps. The first and second pumps are configured, when activated, to pump fluid in opposite directions from one another. Other applications are also described.

IMPLANTABLE FLOW ADJUSTER

An implantable flow adjuster () includes proximal and distal support rings () which support a flow adjuster panel (). The flow adjuster panel () divides the lumen through the device () into two sections, one of reducing cross sectional area and the other of increasing of increasing cross sectional area. The two sections () cause, respectively, an increase in blood pressure and blood flow and a decrease in blood pressure and blood flow. These result is a pressure differential beyond the distal end of the device (). This pressure differential can be used to divert blood flow away from the neck () into an aneurysm (), thus to reduce pressure and wall sheer stress within the aneurysm in order to assist in the repair of the vessel. 1. An endoluminal flow adjuster comprising:an elongate support structure having a tubular shape and a diameter and a proximal end and a distal end, and defining a longitudinal passage for the flow of fluid through the support structure between the proximal end and the distal end, wherein the proximal end and the distal end are open;a panel having a length and a surface extending between the proximal and distal ends of the support structure and held and supported by the support structure, the panel dividing the passage through the flow adjuster into first and second parts varying in size over at least a part of the length of the flow adjuster, wherein the passage defines an overall cross-sectional size perpendicular to the longitudinal direction, and the cross-sectional size of the first and second parts of the passage combine to define the overall cross-sectional size of the passage, and a ratio between the cross-sectional size of the first part and the cross-sectional size of the second part varies over at least a part of the length of the flow adjuster, wherein the first part of the passage is open at both the proximal and distal ends and the second part of the passage is open at both the proximal and distal ends such that fluid flow is ...

TREATING EYE DISEASES BY DEPLOYING A STENT

A method of treating an eye of a patient may include positioning an expandable strut structure within at least one of an internal carotid artery, an ophthalmic artery, or an ostium at a junction between the internal carotid artery and the ophthalmic artery. Additionally, the method may include directing blood flow towards the ophthalmic artery via a diverter element associated with the expandable strut structure. 1. A method of treating an eye of a patient , the method including:positioning an expandable strut structure within at least one of an internal carotid artery, an ophthalmic artery, or an ostium at a junction between the internal carotid artery and the ophthalmic artery; anddirecting blood flow towards the ophthalmic artery via a diverter element associated with the expandable strut structure.2. The method of claim 1 , wherein the step of directing blood flow results in an increase in oxygen delivery to the eye of the patient.3. The method of claim 1 , wherein treating the eye includes treating at least one disease or condition of the eye.4. The method of claim 3 , wherein the at least one disease or condition includes macular degeneration.5. The method of claim 1 , wherein the step of directing blood flow includes altering blood flow through the strut structure via the diverter.6. The method of claim 1 , wherein the step of positioning the expandable strut structure includes positioning the expandable strut structure such that a first portion of the strut structure is positioned within the internal carotid artery upstream of the ophthalmic artery claim 1 , and a second portion of the structure is positioned within the internal carotid artery downstream of the ophthalmic artery.7. The method of claim 6 , wherein the step of positioning the expandable strut structure further includes positioning a third portion of the stent structure within the ophthalmic artery.8. The method of claim 6 , wherein the diverter element extends from the first portion of the ...

Prosthetic Valve With Flow Director

A prosthetic valve comprising a stent frame, a valve structure, and a baffle structure. The stent frame defines a lumen. The valve structure is disposed within the lumen, and defines an inflow side and an outflow side. An outflow track is established within the lumen downstream of the outflow side and along which fluid flow from the valve structure progresses. The baffle structure is connected to the stent frame downstream of the outflow side. In some embodiments, the baffle structure directs blood flow into designated areas to encourage laminar flow and eliminate or reduce turbulence. 1. A prosthetic valve having an inflow end opposite an outflow end , the prosthetic valve comprising:a stent frame defining a lumen;a valve structure disposed within the lumen and configured to define an inflow side and an outflow side opposite the inflow side;wherein an outflow track is established within the lumen downstream of the outflow side and along which fluid flow from the valve structure progresses; anda baffle structure connected to the stent frame downstream of the outflow side.2. The prosthetic valve of claim 1 , wherein the baffle structure is configured and located to encourage laminar flow into blood flow immediately downstream of the outflow side.3. The prosthetic valve of claim 1 , wherein the baffle structure is configured to manipulate a natural flow profile of blood flow at the outflow side of the valve structure.4. The prosthetic valve of claim 3 , wherein the baffle structure is configured to disrupt at least 10% of the natural flow profile.5. The prosthetic valve of claim 1 , wherein the lumen has a diameter and further wherein the baffle structure includes a first baffle member projecting across less than an entirety of the diameter.6. The prosthetic valve of claim 1 , wherein the baffle structure further includes a plurality of baffle members each projecting into the lumen.7. The prosthetic valve of claim 6 , wherein the plurality of baffle members are ...

Methods of intracerebral implant delivery

The method of delivering an implant in an intracranial vessel includes deploying an anchor of a tethering device in an anchoring vessel forming a first fixation point and advancing a guide-sheath to a location near the anchoring vessel. The tethering device has a tether extending proximally from the anchor and the guide-sheath has at least one lumen. The method includes attaching the guide-sheath to the tether of the tethering device forming a second fixation point proximal to the first fixation point, delivering an implant through the lumen of the guide-sheath towards a treatment site distal to the first fixation point and located within an intracranial vessel, and deploying the implant at the treatment site. Related devices, systems, and methods are also provided.

CARDIOVASCULAR VALVE AND VALVE HOUSING APPARATUSES AND SYSTEMS

A cardiovascular valve assembly is disclosed including a housing assembly comprising a first portion and a second portion removably attached to the first portion. A valve may be positioned within the housing assembly. The valve, which may be a mechanical valve, a biological tissue valve, or a polymeric valve, may be structured to allow fluid to flow through the housing assembly in a single direction. In certain embodiments, the valve assembly may further include at least one coupling structure provided on the second portion and at least one aperture defined in the first portion, with the aperture structured to receive the coupling structure to couple the first portion to the second portion. Corresponding systems incorporating cardiovascular valve assemblies are also disclosed. 123.-. (canceled)24. A cardiovascular system , comprising:a tube configured to connect to a tissue wall;a valve positioned within the tube;a cutting member within the tube, the cutting member being configured to cut tissue from the tissue wall to form an opening in the tissue wall;a tissue retraction member configured to remove the tissue cut by the cutting member from the tube; andan anchor extending from the tissue retraction member for anchoring to the tissue to be removed.25. The system of claim 24 , wherein the tube is configured to provide a sealed interface between the tissue wall and a cardiovascular device.26. The system of claim 24 , wherein the tube is cylindrical.27. The system of claim 24 , wherein the tube is sized and dimensioned for implanting to the tissue wall.28. The system of claim 24 , wherein the tube is elongated.29. The system of claim 24 , wherein the tube is configured to attach to the tissue wall.30. The system of claim 29 , wherein the tube is configured to attach to the tissue wall by sutures.31. The system of claim 29 , further comprising a conduit system comprising a conduit and a connector assembly claim 29 , wherein the connector assembly includes expandable ...

THROMBOEMBOLIC PROTECTIVE FLOW-DIVERTING, COMMON CAROTID TO EXTERNAL CAROTID INTRAVASCULAR STENT

Medical procedures and devices suitable for reducing the risk of embolic cerebrovascular events, including but not limited to cardioembolic stroke, that result from emboli entering the right or left common carotid artery. The invention uses a combination of intracranial flow diverting stent technologies and carotid stent technologies to achieve clinical objectives of embolic stroke prevention without thromboembolic and/or vascular stenosis complication. Such a stent has struts that generate high radial forces for endothelial apposition, and a mesh with interstices sufficiently small to prevent clinically significant-sized embolic material from passing therethrough from the common carotid artery into the internal carotid artery, but sufficiently large to enable blood and small clinically insignificant-sized embolic material to pass therethrough from the common carotid artery into the internal carotid artery. 1. A self-expanding intravascular stent adapted for use as a thromboembolic flow-diverting device and placement in the common and external carotid arteries to divert emboli from the internal carotid artery without obstructing blood flow into the internal carotid artery , the stent having a lumen within and defined by a tubular body , the tubular body comprising:a braided mesh formed of filaments defining interstices through the tubular body, the interstices being sufficiently small to prevent embolic material from passing therethrough but sufficiently large to enable blood to pass therethrough; andstruts arranged as a lattice to create scaffolding that generates radial forces greater than the braided mesh when the tubular body of the stent is expanded;wherein in combination the braided mesh and the struts cooperate to create flow dynamics within the lumen of the stent that redirect embolic material entering the lumen away from the origin of the internal carotid artery and into the external carotid artery rather than being filtered or captured by the braided mesh. ...

STENT GRAFT WITH EXTERNAL SCAFFOLDING AND METHOD

A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration. 1. A scaffolded stent-graft comprising:a graft material comprising an inner surface and an outer surface, the inner surface defining a lumen within the graft material; anda scaffold comprising a mesh coupled to the graft material at the outer surface, the scaffold configured to promote tissue ingrowth therein, wherein the mesh is cylindrical.2. A method comprising: engaging a scaffold of the scaffolded stent-graft with a wall of the vessel, the scaffold comprising a mesh promoting tissue ingrowth from the wall into the scaffold; and', 'extending a graft material of the scaffolded stent-graft across the aneurysm., 'deploying a scaffolded stent-graft into a vessel to exclude an aneurysm comprising3. The method of further comprising:filling the aneurysm with the scaffold.4. The method of wherein the scaffold is configured to occlude a branch vessel extending to the aneurysm. This application is a divisional of pending U.S. patent application Ser. No. 15/043,246, entitled “STENT GRAFT WITH EXTERNAL SCAFFOLDING AND METHOD”, filed Feb. 12, 2016, which is incorporated herein by reference in its entirety.The present application relates to an intra-vascular device and method. More particularly, the present application relates to a device for treatment of intra-vascular diseases.A conventional stent-graft typically includes a radially expandable reinforcement structure, formed from a plurality of ...

STENT-GRAFT PROSTHESIS WITH PRESSURE RELIEF PORTS

A stent-graft prosthesis includes a graft material having a tubular construction, a frame coupled to the graft material, and a port or opening disposed between a proximal end and a distal end of the graft material. The port or opening is open during deployment of the stent-graft prosthesis to enable blood flow from a graft lumen within the graft material to exit the graft lumen, and the port or opening is blocked upon full deployment of the stent-graft prosthesis to prevent blood flow from within the graft lumen from exiting the graft lumen through the port or opening. 1. A stent-graft prosthesis comprising:a graft material having a tubular construction, the graft material including a proximal end, a distal end, and a graft lumen extending between the proximal end and the distal end;a frame coupled to the graft material; anda port disposed between the proximal end and the distal end of the graft material, wherein the port enables blood flow from the within the graft lumen to exit the graft lumen,wherein the graft material includes an unsupported graft portion between adjacent frame members of the frame, andwherein the stent-graft prosthesis is configured to be folded in situ in the unsupported graft portion into a folded configuration such that the port is blocked to prevent blood flow from within the graft lumen from exiting the graft lumen through the port.2. The stent-graft prosthesis of claim 1 , wherein the unsupported graft portion is in the range of about 4 mm to about 40 mm claim 1 , or about 10 mm to about 30 mm claim 1 , or about 15 mm to about 25 mm in length.3. The stent-graft prosthesis of claim 1 , wherein the port comprises a plurality of ports disposed around a circumference of the graft material.4. The stent-graft prosthesis of claim 1 , wherein in the folded configuration claim 1 , the unsupported portion is folded such that at least a portion of the unsupported portion is disposed within the graft lumen of the graft material proximal of the ...

STENT APPARATUS AND TREATMENT METHODS

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. 1. Apparatus comprising a plurality of stents each having a centre line curving in three dimensions , the plurality of stents including at least one stent with a centre line having right-handed curvature and at least one stent with a centre line having left-handed curvature.2. Apparatus as claimed in claim 1 , comprising a plurality of right-handed curved stents and a plurality of left-handed curved stents.3. A method of treating hypoxia in tissue of a blood vessel claim 1 , the method comprising placing a stent in the vessel claim 1 , the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall.4. A method of treating a subject with diabetic atherosclerosis claim 1 , the method comprising placing a stent in a blood vessel of the subject claim 1 , the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall.5. A method as claimed in or claim 1 , wherein the stent when expanded ex vivo has a helical centre line.6. A method as claimed in claim 1 , or claim 1 , wherein the stent comprises a shape memory material.7. A method as claimed in claim 1 , or claim 1 , wherein the stent comprises a plastically deformable material.8. A ...

Devices and methods for control of blood pressure

Apparatus and methods are described, including identifying a subject as suffering from hypertension. In response to the identifying (a) a radius of curvature of a first set of at least three regions of an arterial wall of the subject is increased at a given longitudinal location, while (b) allowing the first set of regions of the arterial wall to pulsate. A device is implanted inside the artery at the longitudinal location such that the device applies pressure to the arterial wall at a second set of at least three regions of the artery, but does not contact the first set of regions, the first set regions and the second set of regions alternating with each other. Other embodiments are also described.

Implantable self-cleaning blood filters

A blood filter device having occlusion-resistant characteristics. The occlusion-resistant characteristics decrease the likelihood of the filter being blocked by thrombi. The filter device includes at least one anchor portion for anchoring the filter device within one or more arteries, and a filter portion for filtering thrombi from the blood entering the artery. In some embodiments, an anchor portion is capped with a filter cap. In various embodiments, the filter cap is protrudes into the aorta to promote occlusion resistance. In one embodiment, the device can be modified in situ to re-establish normal blood flow through the artery in the unlikely case of thrombotic or other blockage of the filter. In some embodiments, a bypass opening or open channel defining an access port is provided to accommodate passage of surgical instruments into the artery and to enable blood flow to bypass the filter should the filter become heavily occluded.

SYSTEMS AND METHODS FOR TREATMENT OF FLUID OVERLOAD

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein. 121-. (canceled)22. A method of treating a condition , the method comprising:navigating a catheter system into a vein of a patient to implant an impeller assembly in a segment of a vein downstream of a confluence of a branch vessel with the vein;placing a proximal restrictor, located on the catheter system proximal to the impeller assembly, in a second segment of the vein upstream of the confluence; andoperating the impeller assembly and/or the proximal restrictor to create a low pressure region in the branch vessel while allowing fluid to flow from the second segment, past the restrictor balloon, through the impeller assembly, and into the first segment of the vein downstream of the confluence.23. The method of claim 22 , wherein placing the proximal restrictor comprises deploying a first selectively expandable restrictor.24. The method of claim 22 , further comprising deploying a distal restrictor coupled to the catheter system in the segment of the vein downstream of the confluence.25. The method of claim 24 , wherein the proximal restrictor and/or the distal restrictor each comprise an inflatable balloon.26. The method of claim 22 , wherein ...

SYSTEMS AND METHODS FOR TREATMENT OF FLUID OVERLOAD

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein. 121-. (canceled)22. An apparatus for reducing pressure at an outflow of a duct , the apparatus comprising:a catheter comprising a proximal end and a distal end;an impeller operably disposed within the distal end of the catheter;at least one inlet opening into the catheter proximal to the impeller;at least one outlet opening from the catheter distal to at least a portion of the impeller; anda restrictor disposed around the catheter between the inlet opening and outlet opening.23. The apparatus of claim 22 , wherein when the catheter is positioned at an outlet of a thoracic duct with the restrictor in the activated configuration and when the impeller is operating claim 22 , the catheter lowers pressure at the outlet of the thoracic duct.24. The apparatus of claim 22 , wherein the restrictor is an expandable element.25. The apparatus of claim 22 , wherein the restrictor is a compliant balloon.26. The apparatus of claim 22 , wherein the catheter is dimensioned to be positioned within an innominate vein.27. The apparatus of claim 26 , wherein when the restrictor is activated claim 26 , it occludes the vein.28. The apparatus of claim 22 , wherein when ...

System for and method of treating aneurysms

An apparatus for treating an aneurysm in a blood vessel includes a wire to be advanced within a tube and an occlusion element disposed on the wire. The occlusion element includes a cover and an inner anchoring member. The occlusion element is configured to fit within the tube and slide out of an opening at distal end of the tube in response to movement of the wire. The cover is configured to expand to an expanded configuration when advanced into the aneurysm, wherein the cover comprises a diameter that is greater than the diameter of a neck portion of the aneurysm and is configured such that a first portion of the cover contacts an interior surface of the aneurysm and a second portion covers the neck portion of the aneurysm. The inner anchoring member extends from the cover portion and is configured to contact the interior surface of the aneurysm.

TREATING EYE DISEASES BY DEPLOYING A STENT

A method of treating an eye of a patient may include positioning an expandable strut structure within at least one of an internal carotid artery, an ophthalmic artery, or an ostium at a junction between the internal carotid artery and the ophthalmic artery. Additionally, the method may include directing blood flow towards the ophthalmic artery via a diverter element associated with the expandable strut structure. 122-. (canceled)23. A method of treating an eye of a subject , the method comprising:positioning an expandable strut structure within an ophthalmic artery or an ostium at a junction between an internal carotid artery and the ophthalmic artery of the subject, wherein the expandable strut structure has a first end and a second end, and wherein the expandable strut structure tapers from the first end toward the second end; andseating at least one of the first end or the second end of the expandable strut structure closer to the internal carotid artery than another of the first end or the second end of the expandable strut structure,wherein treating the eye includes treating at least one disease or condition of the eye, wherein the at least one disease or condition includes macular degeneration.24. The method of claim 23 , wherein seating the at least one of the first end or the second end of the expandable strut structure closer to the internal carotid artery than another of the first end or the second end of the expandable strut structure claim 23 , includes positioning the first end of the expandable strut structure at the ostium at the junction between the internal carotid artery and the ophthalmic artery of the subject.25. The method of claim 24 , wherein positioning the expandable strut structure further includes positioning the second end of the expandable strut structure in a short limb of the ophthalmic artery.26. The method of claim 25 , wherein positioning the expandable strut structure includes engaging one or more holding elements of the expandable ...

AORTIC PRESSURE LOSS REDUCTION APPARATUS AND METHODS

Apparatus and methods are described including implanting an aortic pressure-loss-reduction device () in a subject's ascending aorta. While the device is inside a catheter (), a distal end of the catheter is placed within the ascending aorta. A proximal covering sheath () of the catheter is retracted such as to uncover at least a portion of a downstream anchor (), such that the uncovered portion of the downstream anchor includes a portion of the frame that does not have material coupled thereto. Subsequently, a distal covering sheath () of the catheter is advanced, such as to cause an upstream anchor () to anchor an upstream end device () to the subject's ascending aorta, by the upstream anchor radially expending against an inner wall of the ascending aorta. Other applications are also described. 119-. (canceled)20. Apparatus comprising:an aortic pressure-loss-reduction device configured to be implanted inside an ascending aorta of a subject, the aortic pressure-loss-reduction device comprising: ["an upstream anchor portion configured to radially expand against an inner wall of a subject's ascending aorta, such as to anchor an upstream end of the aortic pressure-loss-reduction device to the subject's ascending aorta;", 'an intermediate portion configured to define a conduit therethrough, such that blood is configured to flow through the device via the conduit, at least a portion of the conduit diverging, such that a downstream end of the diverging portion has a greater cross-sectional area than an upstream end of the diverging portion, and at least a portion of the intermediate portion comprising struts that form a spiral along the intermediate portion;', "a downstream anchor portion configured to radially expand against an inner wall of a subject's ascending aorta, such as to anchor a downstream end of the aortic pressure-loss-reduction device to the subject's ascending aorta;", 'a first set of sinusoidal struts disposed between a downstream end of the upstream ...

Method of removing an inflated implant from a bladder

An inflated implant, such as an attenuation device, previously implanted in a urinary bladder can later be removed according to a number of different methods. Preferably, removal is accomplished transurethrally. In one embodiment, removal is accomplished by reducing the inflated implant from an enlarged profile to a reduced profile so that it may be withdrawn transurethrally by a removal system. The removal system can be configured differently depending upon whether reduction from the enlarged profile to the reduced profile is accomplished by deflation, compression, and/or other ways.

SEALING APPRATUS AND METHODS OF USE

A system for treating an aneurysm comprises at least a first double-walled filling structure having an outer wall and an inner wall and the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The first filling structure comprises a sealing feature which forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium, thereby minimizing or preventing blood flow downstream of the seal. 1. A system for treating an aneurysm , said system comprising:at least a first double-walled filling structure having an outer wall and an inner wall, wherein the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow; anda sealing feature, the sealing feature forming a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium, thereby minimizing or preventing blood flow downstream of the seal.2. The system of claim 1 , wherein the sealing feature is disposed in a neck of the aneurysm and/or disposed upstream of the aneurysm.3. The system of claim 1 , wherein the sealing feature comprises an annular cuff disposed at least partially about the first filling structure.4. The system of claim 3 , wherein the annular cuff is disposed about a neck region of the filling structure.5. The system of claim 3 , wherein the sealing feature comprises a thrombogenic material.6. The system of claim 5 , wherein the thrombogenic material is selected from the group consisting of polyurethane claim 5 , polycarbonate claim 5 , polyester claim 5 , ePTFE claim 5 , ...

Flow modification in body lumens

The devices and methods described herein include an implantable body lumen fluid flow modulator including an upstream flow accelerator separated by a gap from a downstream flow decelerator. The gap is a pathway to entrain additional fluid from a branch lumen(s) into the fluid stream flowing from the upstream flow accelerator to the downstream flow decelerator.

DEVICES AND METHODS FOR ASSISTING VALVE FUNCTION, REPLACING VENOUS VALVES, AND PREDICTING VALVE TREATMENT SUCCESS

Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In an exemplary embodiment of an endograft body configured for expansion within a luminal organ, the endograft body comprises (a) a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion configured to increase a velocity of fluid flowing therethrough, (b) a second portion having a second portion proximal end defining a second portion proximal end aperture and a second portion distal end defining a second portion distal end aperture, wherein the distal end of the first portion is adjacent to the second portion proximal end, and (c) a valve portion positioned at or near the second portion proximal end, the valve portion configured to receive the fluid flowing through the distal end aperture of the first portion. 1. An endograft valve device , comprising: a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion internally tapered inward from the proximal end to the distal end when the endograft body is expanded and configured to increase a velocity of fluid flowing therethrough;', 'a second portion having a second portion proximal end defining a second portion proximal end aperture and a second portion distal end defining a second portion distal end aperture, wherein the distal end of the first portion is adjacent to the second portion proximal end; and', 'a valve portion positioned at or near the second portion proximal end or the distal end of the first portion, the valve portion configured to receive the fluid flowing through the distal end aperture of the first portion., 'an endograft body configured for expansion within a luminal organ, the endograft body comprising2. The endograft valve device of claim 1 , wherein the second portion tapers toward the second portion distal end so that the ...

A STENT

A stent () comprising a tubular frame () comprising a first end () and a second end and a longitudinal axis () therebetween. The frame () comprises a plurality of struts () defining a generally cylindrical portion comprising a longitudinally extending helical fin () protruding radially inwardly and having a helix angle. The angle, relative to the longitudinal axis (), of at least some of the struts () in the helical fin () is substantially aligned with the helix angle of the helical fin (). 1. A stent comprising a tubular frame comprising a first end and a second end and a longitudinal axis therebetween , wherein the frame comprises a plurality of struts defining a generally cylindrical portion comprising a longitudinally extending helical fin protruding radially inwardly and having a helix angle and wherein the angle , relative to the longitudinal axis , of at least some of the struts in the helical fin is substantially aligned with the helix angle of the helical fin.2. The stent of claim 1 , wherein the angle of at least some of the struts in the side wall of the helical fin is substantially the same as the helix angle of the helical fin.3. The stent of claim 1 , wherein at least some of the struts in the tubular frame are arranged in a series of repeating elements and claim 1 , in the repeating elements located in the helical fin claim 1 , at least 10% of the total strut length in each repeating element is substantially aligned with the helical fin claim 1 , preferably at least 20% claim 1 , 30% claim 1 , 40% or 50% of the total strut length.4. The stent of claim 1 , wherein the struts delineate a plurality of circumferential rings having a wave form.5. The stent of claim 4 , wherein the wave form comprises a plurality of peaks extending towards the first end of the frame and a plurality of troughs extending towards the second end of the frame claim 4 , wherein each trough is connected to a peak by a connecting strut and wherein the angle of each trough-to-peak ...

STENT HAVING EXTERIOR PATH

A stent according to the present invention includes: a stent main body that has a plurality of holes formed in the surface thereof and a circumferential part of which the inside is hollow; and a cover that covers one side of the outer circumferential surface of the stent main body, in which the stent main body has an exterior path that provides a channel through which the body fluid secreted from a diverging duct can flow along the longitudinal direction of the stent main body to the outside of the cover. 1. A stent comprising:a stent main body that has a plurality of holes formed in the surface thereof and a circumferential part of which the inside is hollow; anda cover that covers one side of the outer circumferential surface of the stent main body,wherein the stent main body has an exterior path that provides a channel through which the body fluid secreted from a diverging duct can flow along the longitudinal direction of the stent main body to the outside of the cover.2. The stent of claim 1 , wherein the external path is formed by a recession on a side of the circumferential part of the stent main body and the recession is formed along the longitudinal direction of the stent main body so that the body fluid secreted from the diverging duct flows through the recession.3. The stent of claim 1 , wherein the external path is formed by a projection on a side of the circumferential part of the stent main body and the projection is formed along the longitudinal direction of the stent main body so that the body fluid secreted from the diverging duct flows through a spaced space formed between the duct and the stent main body by the projection.4. The stent of claim 1 , wherein a plurality of external paths is provided.5. The stent of claim 4 , wherein the external paths are formed by recessions and projections repeatedly formed along the circumferential part of the stent main body and the recessions and the projections are formed along the longitudinal direction of the ...

GRADUALLY RESTRICTING VASCULAR BLOOD FLOW

Disclosed are implant and method for gradually restricting vascular blood flow in a host blood vessel. The implant N comprising an elongated body and at least one holding member. Implant body comprising a flow restricting portion enclosing a variable minimal internal diameter. Holding member is configured for restraining implant body to maintain the variable minimal internal diameter in a first minimal internal diameter, and to physically yield voluntarily after a first predetermined average duration of being continuously subjected to internal human body conditions, thereby releasing and allowing the implant body to elastically deform voluntarily such that the variable minimal internal diameter changes to a second minimal internal diameter, smaller than the first minimal internal diameter. 1. An implant for gradually restricting vascular blood flow , comprising:an elongated implant body comprising a flow restricting portion enclosing a variable minimal internal diameter; andat least one first holding member configured for restraining the implant body to maintain the variable minimal internal diameter in a first minimal internal diameter, the at least one first holding member is configured to physically yield voluntarily after a first predetermined average duration of being continuously subjected to internal human body conditions, thereby releasing and allowing the implant body to elastically deform voluntarily such that the variable minimal internal diameter changes to a second minimal internal diameter, smaller than the first minimal internal diameter.2. The implant according to claim 1 , wherein at least a portion of the elongated body is configured as a stent and/or a mesh claim 1 , and/or is formed by way of braiding claim 1 , weaving claim 1 , knitting claim 1 , extruding or laser cutting.3. The implant according to claim 1 , wherein the first holding member is formed of a biodegradable material claim 1 , optionally particularly configured as a biodegradable ...

IMPLANTABLE FLOW DIVERTER

A flow diverter for implantation into a patient's vessel includes a distal annular support element and a proximal annular support element, the proximal and distal support elements supporting a longitudinally twisted diverter element. The flow diverter is designed to be disposed within a vessel and to impart a rotational or twisting motion to the flow of blood passing therethrough, thereby to reduce the pressure of blood at the center of the vessel. Such flow diversion can reduce the pressure of blood impinging upon an aneurysm at a bifurcation downstream of the vessel. The device can be particularly useful for the treatment of aneurysms occurring at the bifurcation between the basilar artery and the posterior cerebral arteries. 1. A method of treating or preventing an aneurysm at a bifurcation in a circulatory system , the method comprising:implanting an endoluminal flow diverter in a blood vessel upstream of the bifurcation to divert blood flow, the endoluminal flow diverter comprising a proximal support at a proximal end of the diverter and a distal support at a distal end of the diverter, the endoluminal flow diverter defining a longitudinal axis therethrough, the endoluminal flow diverter comprising a panel disposed between and connected to the proximal and distal supports, the panel having a helical twist formed therein about the longitudinal axis.2. The method of claim 1 , wherein the panel twists by an angle of about 90 degrees between the proximal and distal supports.3. The method of claim 1 , wherein the panel is formed of a sheet of material.4. The method of claim 1 , wherein the proximal and distal supports are each ring-shaped.5. The method of claim 4 , wherein the proximal and distal supports are radially compressible.6. The method of claim 4 , wherein the proximal and distal supports in a radially expanded state define a device diameter claim 4 , the device diameter being substantially equal to the diameter of the blood vessel.7. The method of claim 6 ...

CURVED FIBER ARRANGEMENT FOR PROSTHETIC HEART VALVES

A leaflet including fibers oriented at an angle relative to at least one free edge of the leaflet. A leaflet including mechanisms for increasing coaptation height, preventing billowing, and reducing stress in critical regions of the leaflet. A prosthetic heart valve, including three leaflets operatively attached together. A method of using a prosthetic heart valve, by applying pressure to the valve, forming a pocket with material of three leaflets operatively attached together and increasing coaptation height, reducing billowing of the leaflets toward a ventricle, and reducing stress in critical regions of the leaflet. A chorded valve including at least one leaflet, wherein bundles of fibers exit said free edges as tethers an can be anchored to tissue. A method of using the chorded valve, by anchoring the tethers to tissue, forming a pocket with the material of leaflets and increasing coaptation height, and reducing billowing of leaflets toward an atrium. 124-. (canceled)25. A prosthetic heart valve , comprising three leaflets operatively attached together , wherein at least one leaflet includes a stretchable material and at least one of v-shaped or curved fibers , wherein the fibers are inextensible such that when the at least one leaflet is pressurized , a central portion of the fibers is straightened as the valve undergoes deformations and displacements tangent to a surface of the leaflet.26. The prosthetic heart valve of claim 25 , wherein the at least one leaflet is attached to a frame.27. The prosthetic heart valve of claim 25 , wherein the at least one leaflet is attached to a flexible conduit.28. The prosthetic heart valve of claim 25 , wherein said fibers are curved with respect to said free edge.29. The prosthetic heart valve of claim 25 , wherein said fibers are arranged in a V shape opening toward said free edge.30. The prosthetic heart valve of claim 25 , wherein said fibers are nonuniform and at least some of the fibers are arranged in a shape that ...

TRANSCATHETER DEVICE AND MINIMALLY INVASIVE METHOD FOR CONSTRICTING AND ADJUSTING BLOOD FLOW THROUGH A BLOOD VESSEL

A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery. 1. A pulmonary artery flow restrictor system comprising:a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes; anda self expanding frame attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.2. The pulmonary artery flow restrictor system of in which the frame includes arms extending upward over the membrane distal opening.3. The pulmonary artery flow restrictor system of in which the funnel shaped membrane is made of a polymer.4. The pulmonary artery flow restrictor system of in which said polymer is polytetrafluoroethylene (ePTFE)5. The pulmonary artery flow restrictor system of in which the frame is made of a shape memory alloy.6. The pulmonary artery flow restrictor system of in which said shape memory alloy is Nitinol.7. The pulmonary artery flow restrictor system of in which the frame includes a stent like structure.8. The pulmonary artery flow restrictor system of in which the frame includes a wire bent to form a series of spaced lower apexes and a series of spaced upper apexes.9. The pulmonary artery flow restrictor system of in which the spaced lower apexes are secured to the proximal base of the membrane.10. The pulmonary artery flow restrictor system of in which the frame further includes a plurality of bent anchoring arms extending upwardly over the membrane distal opening.11. The pulmonary artery flow restrictor system of in which each arm includes members extending from adjacent frame upper apexes.12. The pulmonary artery flow restrictor system of in which said arms cross above the membrane distal opening.13. The pulmonary artery flow restrictor system of ...

DEVICES AND METHODS FOR ASSISTING VALVE FUNCTION, REPLACING VENOUS VALVES, AND PREDICTING VALVE TREATMENT SUCCESS

Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In an exemplary embodiment of an endograft body configured for expansion within a luminal organ, the endograft body comprises (a) a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion configured to increase a velocity of fluid flowing therethrough, (b) a second portion having a second portion proximal end defining a second portion proximal end aperture and a second portion distal end defining a second portion distal end aperture, wherein the distal end of the first portion is adjacent to the second portion proximal end, and (c) a valve portion positioned at or near the second portion proximal end, the valve portion configured to receive the fluid flowing through the distal end aperture of the first portion. 1. An endograft valve device , comprising: a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion internally tapered inward from the proximal end to the distal end;', 'a second portion having a second portion proximal end defining a second portion proximal end aperture and a second portion distal end defining a second portion distal end aperture, wherein the distal end of the first portion is adjacent to the second portion proximal end; and', 'a valve portion positioned between the first portion and the second portion., 'an endograft body configured for expansion within a luminal organ, the endograft body comprising2. The endograft valve device of claim 1 , wherein the second portion tapers toward the second portion distal end so that the second portion distal end aperture has a relatively smaller cross-sectional area than the second portion proximal end aperture when the endograft body is expanded.3. The endograft valve device of claim 1 , wherein the second portion is configured to ...

VASCULAR VALVE PROSTHESIS

A valve prosthetic implant for treating a vein or other blood vessel includes a tubular, expandable anchoring frame extending from a proximal end to a distal end of the implant, a valve seat formed at or near the middle of the anchoring frame, an expandable ball disposed within the lumen of the anchoring frame, and a ball retention tether attached to the expandable ball and to the valve seat and/or the anchoring frame. The anchoring frame may include a cylindrical proximal portion at the proximal end, a cylindrical distal portion at the distal end, an inwardly angled inlet portion between the cylindrical proximal portion and a middle of the anchoring frame, and an inwardly angled outlet portion between the cylindrical distal portion and the middle of the anchoring frame. 1. (canceled)2. A method for treating a vein , the method comprising:deploying a venous valve prosthetic implant out of a distal end of a catheter into the vein,wherein upon exiting the catheter a tubular anchoring member of the venous valve prosthetic implant expands within the vein and contacts an inner wall of the vein to maintain the venous valve prosthetic implant within the vein, and wherein an expandable ball inside the tubular anchoring member expands after exiting the catheter and moves between an open position, in which the ball is positioned to allow forward flow of blood through the venous valve prosthetic implant, and a closed position, in which the ball contacts a valve seat, to prevent or reduce backflow of blood through the venous valve prosthetic implant; andremoving the catheter from the vein.3. The method of claim 2 , wherein deploying the venous valve prosthetic implant out of the distal end of the catheter comprises at least one of retracting a catheter body of the catheter or advancing a deployment plunger of the catheter.4. The method of claim 2 , wherein the tubular anchoring member and the expandable ball comprise a shape memory material.5. The method of claim 2 , further ...

Vessel flow control devices and methods

Systems and methods for treating an afflicted vessel and/or vessel associated with an afflicted tissue of a mammalian patient are presented herein. In particular, devices for the control of flow rate and/or pressure within a vessel of a mammalian patient, and methods of treating an afflicted vessel and/or a vessel associated with an afflicted tissue using the devices are presented herein.

Expandable vascular occlusion device with lead framing coil

An occlusion device that includes an inner embolic element with a proximal section and a distal section, wherein the distal section has a first stiffness and the proximal section has a second stiffness. An expandable mesh is included that is capable of being transformed between a collapsed position and an expanded position, wherein the expandable mesh is disposed over a portion of the proximal section of the inner embolic device and the first stiffness is greater than the second stiffness.

Device for Changing course of vessel and treatment method using the same

The present invention relates to a device for changing a course of a vessel, a method of introducing the device, a method of changing a course of a vessel using the device, and a treatment method of brain-nervous system diseases, such as neurovascular compression syndrome, using the device. In treating a neurovascular compression syndrome, the present invention can reduce risks and side effects of the microsurgery (MVD), such as hearing loss or facial paralysis that may occur due to the microsurgery. Further, since an area of a metal surface is small, a risk of in-stent stenosis or thrombus generation is low even in a vessel of the brain having a small diameter, and a degree of vascular compression by its radial force is low, thereby making it possible to minimize intimal hyperplasia. 1. A device for changing a course of a vessel , the device comprising:a fixed part configured to be elastically expandable to support a vessel wall; andan extension part extending by a predetermined length from the fixed part to change the course of the vessel.2. The device of claim 1 , further comprising a connecting part connecting the fixed part and the extension part to each other.3. The device of claim 1 , wherein the number of fixed part is one or two or more.4. The device of claim 1 , wherein the fixed part has a ring shape.5. The device of claim 4 , wherein the fixed part has a shape in which a top dead center and a bottom dead center are continuously formed.6. The device of claim 5 , wherein the extension part is connected to the top dead center claim 5 , the bottom dead center claim 5 , or any one point of a line connecting the top dead center and the bottom dead center to each other.7. The device of claim 1 , wherein the extension part is formed by an open-type wire.8. The device of claim 7 , wherein the extension part has a straight line shape claim 7 , a spiral shape claim 7 , or a curved line shape.9. The device of claim 1 , further comprising a spherical cap or a bent ...

VASCULAR IMPLANT

A medical implant () includes first and second ring members (), each including a resilient framework () having a generally cylindrical form. A tubular sleeve () is fixed to the first and second ring members so as to hold the ring members in mutual longitudinal alignment, thereby defining a lumen () passing through the ring members. A constricting element () is fit around the sleeve at a location intermediate the first and second ring members so as to reduce a diameter of the lumen at the location. 1. (canceled)2. A medical implant for controlling blood flow in a vessel , comprising:a first expandable cylindrical ring with a first end and a second end opposite the first end, the first end forming an inflow end, the second end forming a middle portion;a second expandable cylindrical ring with a first end and second end opposite the first end, the first end of the second expandable ring forming an outflow end, the second end forming the middle portion, the second expandable ring coupled to the first expandable ring;a lumen extending between the first and second expandable rings; anda cover disposed over the first and second expandable rings,wherein the first and second expandable rings both have a collapsed configuration and an expanded configuration,wherein in the expanded configuration the first end of the first expandable ring is wider than the second end of the first expendable ring, andwherein in the expanded configuration the first end of the second expandable ring is wider than the second end of the second expandable ring, andwherein a pressure of the blood flow is increased due to the narrow second ends of the first and second expandable rings.3. The implant of claim 2 , wherein the cover is a fabric.4. The implant of claim 2 , wherein the cover is stitched to the first or second expandable rings.5. The implant of claim 2 , wherein the cover is fixed to the first or second expandable rings.6. The implant of claim 2 , wherein the first and second expandable ...

Magnetically Activated Arteriovenous Access Valve System and Related Methods

In one aspect, an arteriovenous access valve system may generally include a first valve configured to be positioned at or adjacent to an end of an arteriovenous graft and a second valve configured to be positioned at or adjacent to an opposite end of the arteriovenous graft. In addition, the system may include an actuator assembly in fluid communication with the first and second valves. The actuator assembly may include a housing, a driver assembly positioned within the housing and a drive magnet positioned within the housing. The drive magnet may be rotatably coupled to the driver assembly such that, when the drive magnet is rotated, the driver assembly is configured to be rotatably driven so as to supply fluid to the first and second valves or to draw fluid out of the first and second valves depending on a rotational direction of the driver assembly. 120-. (canceled)21. An arteriovenous access valve system , comprising:a first valve configured to be positioned at or adjacent to a first end of an arteriovenous graft, the first valve movable between a closed position and an opened position;a second valve configured to be positioned at or adjacent to an opposite second end of the arteriovenous graft, the second valve movable between a closed position and an opened position; andan actuator assembly in fluid communication with the first and second valves via first and second flow paths, respectively, the actuator assembly configured to supply fluid through the first and second flow paths to actuate the first and second valves from the opened position to the closed position;wherein, when the actuator assembly is supplying fluid through both the first flow path and the second flow path, a flow restriction for the fluid flowing to the first and second valves differs between the first and second flow paths such that the first valve is moved to the closed position prior to the second valve.22. The arteriovenous access valve system of claim 21 , wherein the first end of the ...

Power system for and method of operation of magnetically-activated arteriovenous access valve system

A power system for and method of operation of an arteriovenous access valve system including two valves positioned near arteriovenous grafts, an actuator assembly in fluid communication with the valves and including a driver assembly, at least one pressure sensor, a separate activator device for driving the driver assembly, and a sensor communications device communicatively coupled to the at least one pressure sensor for wirelessly transmitting pressure measurements. The power system and method also include using an initiator device located in the activator device to power remotely the sensor communications device, for example via near field communication such as via a radio frequency field.

VALVED CONDUIT AND METHOD FOR FABRICATING SAME

Valved conduits having leaflet structures that do not contact an inner surface of a conduit in which they are formed are described herein. 126-. (canceled)27. A valve comprising:a conduit having an inner conduit surface and an outer conduit surface; anda valve structure comprising one or more leaflet, the one or more leaflet having an outer sinus edge, an inner sinus edge, an open sinus edge and a fan, wherein the valve structure is attached to the inner conduit surface at the outer sinus edge and inner sinus edge, wherein the open sinus edge is suspended below the inner conduit surface creating a sinus between the leaflet and the inner conduit surface.28. The valve of claim 27 , wherein the leaflet has a substantially triangular shape.29. The valve of claim 27 , wherein the open sinus edge has a width that is less than the circumference of the conduit between fixture points of the leaflet to the conduit.30. The valve of claim 27 , wherein the outer sinus edge and the inner sinus edge are attached to the conduit by a fluid impervious connection selected from the group consisting of suturing claim 27 , welding claim 27 , fusion claim 27 , applying an adhesive claim 27 , and combinations thereof.31. The valve of claim 27 , wherein the conduit and the valve structure are each individually composed of a biocompatible and hemocompatible polymer.32. The valve of claim 31 , wherein the biocompatible and hemocompatible polymer is a fluoropolymer selected from the group consisting of polytetrafluoroethylene claim 31 , expanded polytetrafluoroethelyne claim 31 , polyester claim 31 , polyethylene terephthalate claim 31 , polydimethylsiloxane claim 31 , polyurethane claim 31 , and combinations thereof.33. The valve of claim 31 , wherein the biocompatible and hemocompatible polymer is a polymer coated with a bioactive coating or surface-modified to include a bioactive material.34. The valve of claim 33 , wherein the bioactive material is selected from the group consisting of ...

STENT APPARATUS AND TREATMENT METHODS

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. 120-. (canceled)21. A method of treating hypoxia in tissue of a blood vessel , the method comprising:placing a stent in a collapsed condition in the vessel;expanding the stent from the collapsed condition to an expanded condition in which the stent has a centre line which curves in three dimensions, so as to cause the vessel to adopt a shape in which it also has a centre line which curves in three dimensions;wherein the stent comprises a shape memory material.22. A method as claimed in claim 21 , wherein the stent when expanded ex vivo has a centre line which curves in three dimensions.23. A method as claimed in claim 22 , wherein when the stent is in an expanded condition in the vessel it has a reduced three dimensional curvature with respect to the three dimensional curvature when expanded ex vivo.24. A method as claimed in claim 21 , wherein the stent when expanded ex vivo has a helical centre line.25. A method as claimed in claim 24 , wherein when the stent is in an expanded condition in the vessel it has a reduced helical amplitude and/or an increased pitch with respect to the helical amplitude and/or pitch of the stent when expanded ex vivo. with the aid of a balloon.27. A method as claimed in claim 21 , wherein the shape memory material is nitinol.28. A method as claimed in claim 21 , wherein expanding the stent from the collapsed condition ...

PULMONARY ARTERY IMPLANT APPARATUS AND METHODS OF USE THEREOF

The present invention relates to an implantable apparatus and methods of use thereof for treating congestive heart failure. An apparatus of this invention may be anchored by implantation of a section of the apparatus within in a branch pulmonary artery, for example the left pulmonary artery, which then positions and anchors another section, for example a device frame section of the apparatus within the main pulmonary artery. A medical device may be attached to the anchored device frame. 2. The apparatus according to claim 1 , wherein the anchor frame is placed in the left pulmonary artery or the right pulmonary artery.3. The apparatus according to claim 2 , wherein when said anchor frame is place in the left pulmonary artery claim 2 , said anchor frame further comprises a protrusion which extends into the right pulmonary artery when said apparatus is in an expanded position.4. (canceled)5. The apparatus according to claim 1 , wherein the apparatus is deliverable in a collapsed configuration by a transcatheter procedure.6. The apparatus according to claim 1 , wherein said device frame further comprises a medical device selected from the group comprising a flow restrictor claim 1 , a valve claim 1 , a filter claim 1 , a pacemaker claim 1 , a sensor or a drug delivery platform.7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)17. The method according to claim 16 , wherein said transcatheter delivery is performed with the apparatus in a collapsed configuration.19. The method according to claim 18 , wherein said anchor frame is placed in the left pulmonary artery or in the right pulmonary artery.20. The method according to claim 19 , wherein when said anchor frame is place in the left pulmonary artery said anchor frame further comprises a protrusion which extends into the right pulmonary artery when said apparatus is in an expanded position.21. (canceled)22. (canceled)23. (canceled)24. (canceled)25. ...

Devices and method for modifying blood pressure in the lungs and pulmonary vasculature by implanting flow modifier(s) in pulmonary vein(s)

The present invention comprises devices, systems and methods for providing flow modifier(s) comprising one-way, two-way or flow restrictors in one or more pulmonary veins to modify the blood pressure in a patient's left atrium or left ventricle.

VESSEL SHAPING DEVICES AND METHODS

An external vascular support for shaping a vein-artery junction between an artery and a vein anastomosed to the artery, the support comprising: an arterial portion that is shaped to be in apposition with an exterior wall of the artery when the artery is accommodated within a lumen of the arterial portion, and a venous portion that is shaped to be in apposition with an exterior wall of the vein when the vein is accommodated within a lumen of the venous portion, wherein the arterial and venous portions are physically connected at an acute angle, and the corner of the acute angle is shaped as a rounding having a radius of curvature in the range of 0.25 mm to 4 mm. 15-. (canceled)6. An external vascular support for shaping a blood flow vessel , comprising:a vessel accommodating portion shaped to be in apposition with an exterior wall of a blood flow vessel when the blood flow vessel is accommodated within a lumen of the vessel accommodating portion,wherein the vessel accommodating portion comprises at least one protrusion configured to press on the exterior wall of the blood flow vessel, the protrusion being dimensioned to modify a blood flow inside the blood flow vessel.7. The external vascular support of claim 6 , wherein the at least one protrusion is pre-formed into the vessel accommodating portion.8. The external vascular support of claim 6 , wherein the at least one protrusion comprises a pre-shaped portion coupled to the vessel accommodating portion.9. The external vascular support of claim 6 , wherein the vessel accommodating portion comprises at least one plastically deformable portion that is adapted for formation of the at least one protrusion upon the application of a pressure to an external wall of the vessel accommodating portion.10. The external vascular support of claim 9 , wherein the at least one plastically deformable portion is adapted to harden over time to retain a shape of the at least one protrusion formed from the application of a pressure.11. ...

DEVICES AND METHODS FOR RESHAPING BLOOD VESSELS

Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction. 1. A method for inhibiting blood flow through a vein , said method comprisingpenetrating an implant consisting of an elongate member having a distal end pre-shaped into a distal anchor and a proximal end pre-shaped into a proximal anchor inwardly through a proximal location in a wall of the vein and outwardly through a distal location in the wall of the vein, wherein the implant is constrained in a straightened configuration while being penetrated;releasing the distal anchor of the implant from constraint to deploy the distal anchor on an exterior surface of the wall adjacent to the distal location;releasing the proximal end of the implant from constraint to deploy the proximal anchor on the exterior surface of the wall adjacent to the proximal location;wherein the deployed anchors of the implant reshape a lumen of the vein between the first and second location to inhibit blood flow.2. A method as in claim 1 , wherein penetrating comprises advancing a cannula through the proximal and distal locations on the wall claim 1 , wherein the implant is carried over a distal region on the cannula.3. A method as in claim 1 , wherein the anchors of the implant comprise coils at each end of the elongate member claim 1 , wherein the coils are straightened when constrained and assume a pre-shaped coil configuration when released from constraint.4. A method as in claim 1 , wherein the distal anchor of the implant is released from constraint after said distal anchor is advanced beyond the exterior ...

Vena-caval device

Apparatus and method are described including identifying a subject as suffering from a condition that causes the subject to have elevated central venous pressure. In response thereto, a device is placed inside the subject's vena cava such that an upstream end of the device is placed at a location upstream of junctions of the vena cava with all of the subject's renal veins. The device defines a passage through the device, at least a portion of the passage converging in a direction from an upstream end of the device to downstream end of the device. Other applications are also described.

ARTIFICIAL VALVED CONDUITS FOR CARDIAC RECONSTRUCTIVE PROCEDURES AND METHODS FOR THEIR PRODUCTION

Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient. 1. A valve structure comprising:a conduit having an inner conduit surface; and a plurality of valve leaflets, each valve leaflet comprising a sinus structure having a sinus edge and a fan structure having a fan edge;', 'wherein at least a portion of the sinus edge is affixed to a portion of the inner conduit surface; and, 'a leaflet structure having an open state and a closed state, the leaflet structure comprisingwherein, when the leaflet structure is in the closed state, the fan edges of the plurality of valve leaflets are mutually disposed to form a plurality of valve gaps between at least a portion of the fan edges and at least a portion of the inner conduit surface.2. The valve structure of claim 1 , wherein claim 1 , when the leaflet structure is in the open state claim 1 , the sinus edges of the plurality of valve leaflets and the portion of the inner conduit surface are mutually disposed to form a plurality of valve gaps between the portion of the sinus edges and the portion of the inner conduit surface.3. The valve structure ...

Treatment methods

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall.

AORTIC IMPLANT

Apparatus and methods are described including inserting an implantable device () into a blood vessel of a subject while the implantable device is disposed inside a delivery device and is constrained in a constrained configuration by the delivery device. The implantable device is released from the delivery device into the blood vessel, thereby causing the implantable device to assume a non-constrained configuration by an upstream end of the implantable device radially expanding (), a central portion () of the implantable device radially expanding such that along the central portion of the implantable device the inner surface () of the implantable device defines a diverging portion () of a conduit (), and the implantable device forming a folded portion () between the upstream end of the implantable device and the central portion of the implantable device. Other applications are also described. 1. Apparatus for use with a delivery device , comprising: to be inserted into an ascending aorta of a subject while the implantable device is disposed inside the delivery device and is constrained in a constrained configuration by the delivery device,', a proximal portion of the implantable device contacts an inner wall of the ascending aorta, such as to anchor the proximal end of the implantable device with respect to the ascending aorta,', the proximal end of the conduit being configured to be placed within the ascending aorta such that when an aortic valve of the subject is in an open state, the proximal end of the conduit is disposed within 25 mm of a tip of the aortic valve,', 'a distal portion of the implantable device contacts the inner wall of the ascending aorta, such as to anchor the distal end of the implantable device with respect to the ascending aorta, and', 'the implantable device defines a folded portion between the proximal portion of the implantable device and the central portion of the implantable device, such that along a longitudinal direction of the ...

METHODS FOR TREATING ABNORMAL GROWTHS IN THE BODY USING A FLOW REDUCING IMPLANT

A flow reducing implant for reducing blood flow in a blood vessel having a cross sectional dimension, the flow reducing implant comprising a hollow element adapted for placement in the blood vessel defining a flow passage therethrough, said flow passage comprising at least two sections, one with a larger diameter and one with a smaller diameter, wherein said smaller diameter is smaller than a cross section of the blood vessel. A plurality of tabs anchor, generally parallel to the blood vessel wall, are provided in some embodiments of the invention. 1. A method of treating a blood flow problem , the method comprising:inserting a flow modifying implant into a vessel;radially expanding the flow modifying implant;engaging the flow modifying implant with the vessel; andmodifying blood flow in the vessel.2. An implantable device for treating a blood flow problem , the device comprising:a radially expandable device having an expanded configuration and a collapse configuration,wherein the collapsed configuration is configured to be delivered to a blood vessel,wherein the expanded configuration is configured to engage a wall of a blood vessel and anchor the radially expandable device in the blood vessel, andwherein in the expanded configuration the radially expandable device is configured to modify blood flow through the blood vessel. The present application is a continuation of U.S. patent application Ser. No. 15/152,935 (Attorney Docket No. 5130.003US5), now U.S. Pat. No. ______, filed on May 12, 2016, which is a continuation of U.S. patent application Ser. No. 14/506,403 (Attorney Docket No. 5130.003US4), now U.S. Pat. No. 9,364,354, filed on Oct. 3, 2014, which is a continuation of U.S. patent application Ser. No. 14/026,816 (Attorney Docket No. 5130.003US3), now U.S. Pat. No. 8,858,612, filed on Sep. 13, 2013, which is a continuation of U.S. patent application Ser. No. 12/603,518 (Attorney Docket No. 5130.003US2), now U.S. Pat. No. 8,556,954, filed Oct. 21, 2009, which ...

Expandable vascular occlusion device with lead framing coil

An occlusion device that includes an inner embolic element with a proximal section and a distal section, wherein the distal section has a first stiffness and the proximal section has a second stiffness. An expandable mesh is included that is capable of being transformed between a collapsed position and an expanded position, wherein the expandable mesh is disposed over a portion of the proximal section of the inner embolic device and the first stiffness is greater than the second stiffness.

Arterial anchor devices forming an anastomotic connector

An arterial anchor device operably coupled by graft material to form an anastomotic connector is provided. The arterial anchor device comprises a generally tubular main body including a distal end and a proximal end, the distal end defining a plurality of flanges integrally formed with the tubular main body and being movable from a first loaded position to a second expanded position. The arterial anchor device is fluidly connected by a graft to form an anastomotic connector.

ARTIFICIAL VALVED CONDUITS FOR CARDIAC RECONSTRUCTIVE PROCEDURES AND METHODS FOR THEIR PRODUCTION

Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient. 1. A heart valve structure comprising:a conduit comprising an inner conduit surface, an outer conduit surface, and a diameter; and a first heart valve leaflet, comprising a first sinus edge and a first fan edge; and', 'a second heart valve leaflet, comprising a second sinus edge and a second fan edge;', 'wherein the first fan edge intersects the second fan edge at an outer commissure point, and the first sinus edge intersects the second sinus edge at an inner commissure point, thereby forming a commissure extending from the outer commissure point to the inner commissure point,', 'wherein the first fan edge intersects the first sinus edge at a first outer leaflet point, thereby forming a first baseline extending from the first outer leaflet point to the commissure, the first baseline further having a first width as measured from the first outer leaflet point to the commissure,', 'wherein the second fan edge intersects the second sinus edge at a second outer leaflet point, thereby forming a second baseline extending from the second ...

COMPLIANT AORTIC STENT GRAFTS AND RELATED SYSTEMS AND METHODS

A vascular implant for an endoluminal stent or blood vessel, the stent or blood vessel defining a lumen for the passage of blood. The liner can comprise a flexible bladder arrangeable within the lumen, which can be fillable with a compressible fluid. The liner can define an inner lumen for the passage of blood. The liner and the fluid are conformable in response to a pulsatile pressure wave of the blood in the blood vessel such that the pressure within the blood vessel is reduced. 1. A liner for an endoluminal stent , the stent defining a lumen for the passage of blood through a blood vessel , the liner comprising:a flexible bladder arrangeable within the lumen and fillable with a compressible fluid, the bladder defining an inner lumen for the passage of blood;wherein the bladder and the fluid are conformable in response to a pulsatile pressure wave of the blood in the blood vessel such that the pressure within the blood vessel is reduced.2. The liner of wherein the bladder comprises a toroid cuff and the liner further comprises: an elongate elastic tube having an axial length at least equivalent to the axial length of the stent.3. The liner of claim 2 , wherein the liner further comprises a first ring at a first axial extent and a second ring at a second axial extent claim 2 , the first ring and the second ring being radially inextensible.4. The liner of claim 1 , wherein the bladder further comprises means for filling the bladder to a desired internal pressure.5. The liner of claim 4 , wherein the means for filling the bladder to a desired internal pressure comprise a self-healing claim 4 , syringe-accessible filling port.6. The liner of claim 4 , wherein the means for filling the bladder to a desired internal pressure comprise a compressed gas compartment.7. The liner of claim 1 , wherein the compressible fluid is selected from the group consisting of: air claim 1 , carbon dioxide claim 1 , oxygen claim 1 , and combinations thereof.8. The liner of claim 1 , ...

Prosthetic Venous Valves

A prosthetic venous valve having a conical shaped base valve member and a biomaterial delivery construct. The base valve member includes a plurality of fluid flow modulating means that open and allow antegrade blood to be transmitted out of the valve member when the valve member receives antegrade blood therein, and close and prevent retrograde blood from flowing into the valve member. The biomaterial delivery construct is adapted to receive and position the base valve member therein, and be disposed proximate a luminal wall of a venous vessel. 1. A prosthetic venous valve for modulating fluid flow through a venous vessel , comprising:a base valve member and a biomaterial delivery construct,said base valve member comprising a first ECM composition comprising first acellular ECM derived from a first mammalian tissue source,said base valve member further comprising a taper region, an internal region, an exterior region, an open proximal valve member end and a closed distal valve member end, said open proximal valve member end being configured and adapted to receive antegrade blood flow therein and direct said antegrade blood flow into said internal region of said base valve member, said open proximal valve member end defining an open valve inlet end comprising a first open area,said base valve member further comprising a plurality of linear interstices disposed in said taper region of said base valve member between said open proximal valve member end and said closed distal valve member end,said base valve member being configured and adapted to expand and transition from a contracted configuration to an expanded configuration when said open proximal valve member end of said base valve member directs first antegrade blood flow into said internal region of said base valve member and a negative hydrostatic pressure gradient is generated proximate said taper region of said base valve member,said plurality of linear interstices being configured and adapted to transition ...

STENT APPARATUS AND TREATMENT METHODS

There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. 120-. (canceled)21. A method of treating a subject for whom blood vessel stenting is indicated , comprising:identifying a treatment site;determining whether natural vessel geometry at that treatment site will impart right-handed swirl flow or left-handed swirl flow to the blood flow along the vessel; andselecting for placement at the treatment site a stent having a centre line with three-dimensional curvature;the selected stent having right-handed curvature if the vessel has been determined to naturally impart right handed swirl flow and the selected stent having left-handed curvature if the vessel has been determined to naturally impart left-handed swirl flow.22. A method as claimed in claim 21 , wherein the step of determining whether the natural vessel geometry at that treatment site will impart right-handed swirl flow or left-handed swirl flow comprises scanning the vessel claim 21 , optionally using a method selected from: x-ray scanning transverse colour doppler ultrasound claim 21 , computer tomography claim 21 , magnetic resonance imaging claim 21 , c-arm cone beam CT.23. A method as claimed in claim 21 , wherein it is determined that the treatment site will impart right-handed swirl flow if the vessel is one of: left iliac artery claim 21 , left iliac vein claim 21 , left femoropopliteal artery claim 21 , left femoropopliteal vein claim ...