УСТРОЙСТВО ДОСТАВКИ ЭНДОВАСКУЛЯРНОГО ПРОТЕЗА

Изобретение относится к области медицинской техники, и в частности, к устройству доставки эндоваскулярного протеза для лечения аневризмы у пациента. Устройство доставки эндоваскулярного протеза содержит трубчатый элемент, имеющий дистальный участок, проксимальный участок и участок для соединения с эндоваскулярным протезом, прикрепленный к дистальному участку. Дистальный участок имеет пористую поверхность, образованную множеством круговых колец, соседние пары которых соединены друг с другом по меньшей мере одной продольной распоркой. Пористая поверхность имеет градиент окружной ширины продольных распорок между продольными распорками, прикрепленными с противоположных сторон одного кругового кольца, уменьшающийся в направлении от проксимального участка к дистальному участку. Каждое круговое кольцо содержит чередующиеся вершины и впадины. По меньшей мере одна продольная распорка соединяет первую впадину на первом круговом кольце со второй впадиной на втором круговом кольце, прилегающем к первому ...

УСТРОЙСТВО ДЛЯ РЕКОНСТРУКЦИИ СОСУДОВ

... 1. По существу, сферическое реконструкционное устройство, содержащее ! первый конец, ! второй конец, по существу, противоположный первому концу, и ! волокна, проходящие между первым концом и вторым концом и соединенные с первым концом и вторым концом, и выполненное с ! возможностью постоянного размещения в месте соединения нейрососудистой бифуркации, содержащей по меньшей мере один афферентный сосуд, эфферентные сосуды и аневризму, имеющую шейку, ! возможностью осуществления функции системы опор с предотвращением грыжеобразования объектов наружу шейки аневризмы и ! возможностью обеспечения перфузии жидкости к эфферентным сосудам. ! 2. Устройство по п.1, которое выполнено в целом в форме футбольного мяча и в котором первый конец и второй конец проходят наружу. ! 3. Устройство по п.1, которое выполнено в целом в форме тыквы и в котором первый конец и второй конец проходят внутрь. ! 4. Устройство по любому из пп.1-3, в котором волокна содержат обладающий памятью формы материал. ! 5. Устройство ...

СИСТЕМЫ И СПОСОБЫ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ РАСШИРИТЕЛЬНОГО КОЛЬЦА

ENDOLUMINALE VORRICHTUNG MIT EINER VERANKERUNGSEINHEIT

GERÄT FÜR DIE AUSWEITUNG EINES KÖRPERLUMENS UND DAS EINSETZEN EINER PROTHESE IN DIESEM LUMEN

Medical device with plasma modified oxide layer and method of forming such a device

Implantable graft assembly and aneurysm treatment

Stent element

There is provided a stent element 1 comprising a central portion 2 with two arms 3, 3, 3â , 3â extending therefrom, optionally in a V-shaped or Y-shaped configuration. The arms 3, 3â of the stent element 1 are resiliently deformable, optionally made from nitinol. Also disclosed is a stent graft 10, which comprises the stent element 1, a sleeve 4 and at least two ring stents 5, 6. The stent element 1 is attached to the sleeve so that it bridges the distance between the ring stents 5, 6. An implantable prosthesis is further disclosed, comprising a compliant and fluid impervious sleeve 4 and first and second ring stents 5, 6 which are made from multiple windings of wire of shape memory material. The first and second ring stents 5, 6 are attached to the sleeve 4 at first and second locations, and the stent element 1 also attaches to the sleeve 4 at these first and second locations. A method of manufacture is also disclosed.

STENT AND METHOD OF INSERTING A STENT INTO A DELIVERY CATHETER

A stent 2 and method of inserting a stent 2 into a delivery catheter are disclosed. In a disclosed embodiment, a stent 2 for redirecting blood flow away from an aneurysmal sac is provided. The stent comprises an elongate frame that is radially contractable from a fully radially expanded state (Figure 2) to a radially contracted state (Figure 3) in a process involving elongation of the frame. The fully radially expanded state represents the state of the frame at body temperature when no external force is applied to the frame. In the radially contracted state the frame has a maximum lateral dimension that is at least 30% smaller than the maximum lateral dimension of the frame in the fully radially expanded state. The frame further comprises a low porosity region 4 for positioning at the opening to the aneurysmal sac, the low porosity region having a porosity of less than 50% when the frame is in the fully radially expanded state.

Aneurismal sack deflator

Regulation/modification of stent contact surface for polymer free drug coating

Delivery system for deploying a self-expanding tube, and method of deploying a self-expanding tube

ENDOVASKULÄRE PROSTHESIS

Delivery of medical devices

DELIVERY OF MEDICAL DEVICES A stent delivery system (100) can include an elongate core member (160) sized for insertion into a blood vessel (102). The core member (160) can be configured to advance a stent (200) toward a treatment location in the blood vessel (102). The core member (160) can include a longitudinally extending tube (170) having a helical cut extending along the tube (170). The helical cut can have an axial length of at least 50 cm and be continuous along the axial length.

Endoluminal device and method

An endoluminal device can be configured for precise positioning during deployment within a vessel. The endoluminal device can be a tack, stent, vascular implant or other type of implant. The endoluminal device can have circumferential member with an undulating configuration having multiple inward and outward apexes and struts extending therebetween. Two of the struts can be used to establish a foot for the precise positioning of the device during deployment. A method of placing the endoluminal device can include withdrawing an outer sheath such that a portion of the endoluminal device is expanded prior to the rest of the endoluminal device. 2a F/Gol25F ...

Endoluminal device and method

An endoluminal device can be configured for precise positioning during deployment within a vessel. The endoluminal device can be a tack, stent, vascular implant or other type of implant. The endoluminal device can have circumferential member with an undulating configuration having multiple inward and outward apexes and struts extending therebetween. Two of the struts can be used to establish a foot for the precise positioning of the device during deployment. A method of placing the endoluminal device can include withdrawing an outer sheath such that a portion of the endoluminal device is expanded prior to the rest of the endoluminal device. 2a F/Gol25F ...

Flexible vascular occluding device

Radially expandable stent featuring aneurysm covering surface

Aneurysm treatment device

Implant comprising a non-woven fabric

The invention relates to a membrane implant for treating vascular malformations, for the endovascular implantation into the vessel to be treated, the membrane implant consisting of an expandable stent (4) and a membrane (2, 3, 5, 11) connected to the stent (4). Said membrane (2, 3, 5, 11) covers mesh of the stent (4) at least in a center region and is designed as a non-woven fabric that contains synthetic filaments. The membrane (2, 3, 5, 11) is integrally connected to the stent (4) and is porous in at least some sections.

Flexible vascular occluding device

Systems and methods for magnetized stent having growth-promoting properties

Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm. The magnetic region can serve to attract and position both residua! red biood cells and magnetically nano-ireated growth-promoting ceils to the orifice area of the aneurysm. The outer circumference of the tubular elongated body can act as a floor or scaffold for regenerated smooth vascular muscle cells. In embodiments, the tissue nidus area can be provided on the exterior stent, while the magnetized region is provided on the interior stent, of a stent-in-stent structure. In embodiments, the exterior stent is made of biodegradable material which gradually dissolves or dissipates in situ.

Radially expandable aneurysm treatment stent

Push and pull medical device delivery system

A system for delivery of a medical device includes a delivery member (206) and a medical device (500), which is mounted to the delivery member and releasably retained in a delivery configuration for endoluminal delivery of the medical device toward a treatment site in a human vessel. The delivery member includes an elongated first portion (205) configured to extend outside of the body from a first percutaneous access site (102) and an elongated second portion (207) configured to extend outside the body from a second percutaneous access site (104) to allow positioning of the medical device at the treatment site by manipulation of the first portion and second portion from outside of the body.

Means for controlled sealing of endovascular devices

Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prosthesis), contained, not open, release of the material, active conformation to the "leak sites" such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.

Implant

The invention relates to an implant for use in the occlusion of aneurysms in the region of vascular ramifications, in particular bifurcation aneurysms (A). The implant has a mesh structure (3, 4) and comprises, from a proximal end to a distal end, a fastening segment (b), by means of which the implant can be supported on a vessel wand, a permeable segment (c) for the region of the vascular ramification, and a distal segment (d), in which the implant is radially expanded in relation to segment (b) and which is intended to be placed in the aneurysm (A). In the region of segment (c) or (d), a separating zone (T1, T2), is arranged, which at least partially closes the throat of the aneurysm, wherein the distal segment (d) has a plurality of filaments and/or loops (12) connected to segment (c) and the filaments/loops (12) form an angle between -45° and +175° to the longitudinal axis of the implant (1), wherein a positive angle stands for filaments/loops pointing radially outward and a negative ...

Implant insertion system

The invention relates to a device for introducing an implant (1) into blood vessels or hollow organs of the human or animal body, comprising an implant (1), an insertion wire (14), and a transfer tube (13), wherein the implant (1) can be deformed in such a way that, in a micro-catheter (8), the implant assumes a form having a reduced diameter and, at the implantation location, following the removal of the external force by the micro-catheter (8), expands whilst adapting to the diameter of the blood vessel or hollow organ. A a holding element (2) is arranged on the insertion wire (14) and the holding element (2) has peripherally at least one, preferably multiple, grooves (3) let into the holding element (2), which extend on the circumference of the holding element (2) and form tracks in the form of curved lines. The implant (1) has at the proximal end at least one, preferably multiple, holding wires (5) extending in the proximal direction and fitted into the grooves (3), wherein the transfer ...

Endoluminal device and method

An endoluminal device can be configured for precise positioning during deployment within a vessel. The endoluminal device can be a tack, stent, vascular implant or other type of implant. The endoluminal device can have circumferential member with an undulating configuration having multiple inward and outward apexes and struts extending therebetween. Two of the struts can be used to establish a foot for the precise positioning of the device during deployment. A method of placing the endoluminal device can include withdrawing an outer sheath such that a portion of the endoluminal device is expanded prior to the rest of the endoluminal device.

Protuberant aneurysm bridging device and method of use

PROTUBERANT ANEURYSM BRIDGING DEVICE AND METHOD OF A method of placing an endoluminal support, said method comprising the steps of advancing the endoluminal support within a catheter (2) in a collapsed configuration; placing the endoluminal support within vasculature of a patient to permit a distal end portion of the support to expand from the collapsed configuration to an expanded configuration; securing the distal end portion of the endoluminal support within the vasculature in the expanded configuration; after the distal end portion is secured, manipulating a proximal end portion of the endoluminal support to deform a central region of the endoluminal support; and securing the proximal end portion of the endoluminal support within the vasculature to maintain the central region of the endoluminal support in a deformed state.

Endovascular thin film devices and methods for treating and preventing stroke

ENDOVASCULAR THIN FILM DEVICES AND METHODS FOR TREATING AND PREVENTING STROKE

Devices for excluding aneurysms and treating atherosclerotic disease, for intra-aneurysmal occlusion, and devices for preventing distal emboli. The devices are generally pliable and collapsible thin film devices which can be delivered via a microcatheter into the desired location where they are deployed and undergo either a shape memory phase transformation or in situ polymerization to assume the stable configuration of a permanent endoluminal prosthesis. Prior to being caused to assume their final shape, the devices remain soft, collapsible and pliable to ensure atraumatic delivery through the vascular system. Upon reaching the endoluminal defect in the vessel, the device is extruded from the microcatheter. Devices are also provided for retrieving clots.

INTRAVASCULAR DELIVERABLE STENT FOR REINFORCEMENT OF VASCULAR ABNORMALITIES

A catheter deliverable stent/graft especially designed to be used in a minimally invasive surgical procedure for treating a variety of vascular conditions such as aneurysms, stenotic lesions and saphenous vein grafts, comprises an innermost tubular structure and at least one further tubular member in coaxial arrangement. In one embodiment, the innermost tubular structure is of a length (L1) and is formed by braiding a relatively few strands of highly elastic metallic alloy. The pick and pitch of the braid are such as to provide relative large fenestrations in the tubular wall that permit blood flow through the wall and provide the primary radial support structure. A portion of the innermost tubular structure of a length L1 is surrounded by a further braided tubular structure having relatively many strands that substantially inhibit blood flow through the fenestrations of the innermost tubular structure. The composite structure can be stretched to reduce the outer diameter of the stent/graft ...

ENDOLUMINAL DEVICE HAVING BARB ASSEMBLY AND METHOD OF USING SAME

An endoluminal device for implantation in a body lumen reduces movement or migration of the device after implantation by the use of barbs or barb assemblies. A first embodiment uses at least one barb assembly (105) having first portions (270) attached to an implant (100), a bend (280), and second portion (275) disposed opposite the first portion from the bend (280) and having a bearing surfaced (285). The second portion (275) is adapted to protrude radially inward when the inplant (100) is in the radially compressed configuration and radially outward when the implant (100) is in its radially expanded configuration. A second embodiment uses a barb (405) having a curved segment which is curved proximally and radially inwardly. A third embodiment utilizes at least one barb assembly (505) having a wire (507) with a length greater than the cell height of the implant across which it extends and a substantially uniform cross - sectional area.

MINIMAL SURFACE AREA CONTACT DEVICE FOR HOLDING PLAQUE TO BLOOD VESSEL WALL

A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of focal elevating elements on its outer annular periphery for holding loose plaque under a spring or other expansion force against a blood vessel wall. The focal elevating elements are designed to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the intraluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.

ANEURYSM TREATMENT DEVICE AND METHOD OF USE

The present application discloses an apparatus for treating vascular aneurysms and includes a radially expandable substantially cylindrical structure formed from a plurality of support members and defining a plurality of openings, and at least one reactive material strand selectively integrated into the substantially cylindrical structure. The reactive material is configured to assume a non-reacted state and a reacted state. The reactive material in the reacted state is configured to restrict a flow of blood to an aneurysm.

HYBRID STENT

A stent includes a high radial/crush force segment and a highly flexible segment. In an aspect, a plurality of first ring struts connected such that each of the plurality of first rings comprises a sinusoidal pattern having a plurality of apices and troughs, each first ring connected to an adjacent first ring by at least one connector. The connector extends from a ring strut of the first ring from a position near an apex of the first ring to a ring strut of the adjacent first rings near an apex of the adjacent ring, and a second stent segment comprises a plurality of second rings connected to one another to form a series of second rings.

STENT DELIVERY WITH EXPANSION ASSISTING DELIVERY WIRE

An expandable element having a distal anchor member at a distal end, a proximal anchor member at a proximal end, and a braided intermediate portion can be delivered to a treatrnent site through a catheter by a delivery wire having a first, distal bump that can be translated distally to push the distal anchor distally and release the distal anchor upon exiting a distal end of the catheter, a shaped segment that can be moved to apply a radial force from within the braided intermediate portion to expand the braided intermediate portion, and a second, proximal bump that can be translated distally to push the proximal anchor distally and expel the expandable element from the catheter. The delivery wire can also have a third, recapture bump positioned between the proximal and distal bumps that can be translated proximally to retract a partially iniplanted expandable element into the catheter.

FLEXIBLE VASCULAR OCCLUDING DEVICE

A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain. The neurovascular occluding device and be deployed using a micro-catheter. The occluding device can be formed braiding wires in a helical fashion and can have varying lattice densities along the length of the occluding device. The occluding device could also have different lattice densities for surfaces on the same radial plane.

DELIVERY OF MEDICAL DEVICES

A stent delivery system can include an elongate core member sized for insertion into a blood vessel. The core member can be configured to advance a stent toward a treatment location in the blood vessel. The core member can include a longitudinally extending tube having a helical cut extending along the tube. The helical cut can have an axial length of at least 50 cm and be continuous along the axial length. DM US 45401381-1.080373.0657 ...

BRAIDED FLOW DIVERTER USING FLAT-ROUND TECHNOLOGY

A generally tubular braided flow diverting stent is formed of alternating round and rectangular elongated members, for treatment of aneurysms. The generally tubular braided flow diverting stent maintains a significant wall thickness while increasing area coverage of a vessel wall. Sliding of the round elongated members over the rectangular elongated members allows the stent to be crimped to very low diameters for delivery in narrow portions of the vasculature.

MODIFIABLE OCCLUSION DEVICE

An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a pre-established pore features and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material associated with the pore features which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.

EMBOLIC IMPLANT AND METHOD OF USE

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

ENDOVASCULAR PROSTHESIS AND DELIVERY DEVICE

In one of its aspects, the present invention relates to an endovascular prosthesis. The endovascular prosthesis comprises a first expandable portion expandable from a first, unexpanded state to a second, expanded state to urge the first expandable portion against a vascular lumen and a retractable leaf portion attached to the first expandable portion. The retractable leaf portion comprises at least one spine portion and a plurality of rib portions attached to the spine portion. Longitudinally adjacent pairs of rib portions are free of interconnecting struts. The endovascular prosthesis that can be unsheathed and re- sheathed for repositioning of the endovascular prosthesis prior to final deployment thereof. There is also described a delivery device that is particularly well suited to delivering the present endovascular prosthesis through tortuous vasculature in the body.

ENDOLUMINAL DEVICE HAVING BARB ASSEMBLY

An endoluminal device for implantation in a body lumen reduces movement or migration of the device after implantation by the use of barbs or barb assemblies. A first embodiment uses at least one barb assembly (105) having first portions (270) attached to an implant (100), a bend (280), and second portion (275) disposed opposite the first portion from the bend (280) and having a bearing surfaced (285). The second portion (275) is adapted to protrude radially inward when the inplant (100) is in the radially compressed configuration and radially outward when the implant (100) is in its radially expanded configuration. A second embodiment uses a barb (405) having a curved segment which is curved proximally and radially inwardly. A third embodiment utilizes at least one barb assembly (505) having a wire (507) with a length greater than the cell height of the implant across which it extends and a substantially uniform cross - sectional area.

PROTUBERANT ANEURYSM BRIDGING DEVICE AND METHOD OF USE

A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

STENT AND STENT DELIVERY DEVICE

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

ДОСТАВЛЯЕМЫЙ ПОСРЕДСТВОМ КАТЕТЕРА ВНУТРИСОСУДИСТЫЙ СТЕНТ/ИМПЛАНТАТ ДЛЯ ЛЕЧЕНИЯ СОСУДИСТЫХ АНОМАЛИЙ И СПОСОБ ЛЕЧЕНИЯ СОСУДИСТЫХ АНОМАЛИЙ

Предложен доставляемый посредством катетера внутрисосудистый стент/имплантат, устанавливаемый путем операции с минимальным хирургическим вмешательством, предназначенный для лечения ряда сосудистых аномалий, таких как аневризмы, стенозы и аномалии шунтов коронарной артерии, и содержащий переплетенные трубчатые структуры, самая внутренняя из которых окружена по меньшей мере одной расположенной соосно с ней дополнительной трубчатой структурой. В одном из вариантов осуществления изобретения самая внутренняя трубчатая структура имеет длину L1 и образована путем переплетения относительно небольшого количества жил из высокоэластичного металлического сплава. Плотность расположения и угол наклона металлических жил самой внутренней трубчатой структуры таковы, что межжильные щели в ней имеют достаточно большие размеры, для обеспечения возможности прохождения крови сквозь ее стенку, а диаметр этих металлических жил выбран таким образом, чтобы обеспечивалась возможность использования самой внутренней ...

ДОСТАВЛЯЕМЫЙ ПОСРЕДСТВОМ КАТЕТЕРА ВНУТРИСОСУДИСТЫЙ СТЕНТ/ИМПЛАНТАТ ДЛЯ ЛЕЧЕНИЯ СОСУДИСТЫХ АНОМАЛИЙ И СПОСОБ ЛЕЧЕНИЯ СОСУДИСТЫХ АНОМАЛИЙ

Предложен доставляемый посредством катетера внутрисосудистый стент/имплантат, устанавливаемый путем операции с минимальным хирургическим вмешательством, предназначенный для лечения ряда сосудистых аномалий, таких как аневризмы, стенозы и аномалии шунтов коронарной артерии, и содержащий переплетенные трубчатые структуры, самая внутренняя из которых окружена по меньшей мере одной расположенной соосно с ней дополнительной трубчатой структурой. В одном из вариантов осуществления изобретения самая внутренняя трубчатая структура имеет длину L1 и образована путем переплетения относительно небольшого количества жил из высокоэластичного металлического сплава. Плотность расположения и угол наклона металлических жил самой внутренней трубчатой структуры таковы, что межжильные щели в ней имеют достаточно большие размеры для обеспечения возможности прохождения крови сквозь ее стенку, а диаметр этих металлических жил выбран таким образом, чтобы обеспечивалась возможность использования самой внутренней ...

의료용 장치의 전달

... 스텐트 전달 시스템은 혈관 내로 삽입하도록 크기가 형성된 신장된 코어 부재를 포함할 수 있다. 코어 부재는 혈관 내의 치료 위치를 향하여 스텐트를 전달시키도록 구성될 수 있다. 코어 부재는 튜브를 따라 연장된 나선형 절단부를 갖는 종방향으로 연장된 튜브를 포함할 수 있다. 나선형 절단부는 50 cm 이상의 축방향 길이를 가질 수 있고 축방향 길이를 따라 연속적일 수 있다.

VASCULAR STENTING FOR ANEURYSMS

implante para vasos sanguíneos e combinação de um implante

IMPLANT

IMPLANTABLE GRAFT ASSEMBLY AND ANEURYSM TREATMENT

Disclosed is an implantable graft assembly comprising a graft secured to a expandable tubular frame, the graft only partially covering the frame and the use of the graft assembly in treating an aneurysm, especially a cerebral aneurysm. Disclosed is also a method of treating an aneurysm by deploying an implantable graft assembly. Disclosed is also the use of serous tissue for the preparation of a cerebrovascular implant, especially as a graft, especially as a component of a cerebrovascular implantable graft assembly.

A STENT

An endovascular stent, including: a guide portion and a drive portion; a plurality of flexible support arms, each including two opposing ends that are coupled to said guide portion and said drive portion respectively, said arms being moveable relative to each other between an expanded position and a compressed position; and said stent including at least one barrier portion, such that when said arms are moved to said expanded position, said arms configure the barrier portion into a selectively permeable barrier through which one or more articles may be introduced into a space between said barrier and a wall of a lumen receiving said stent.

STENT VASCULAR INTERVENTION DEVICE AND METHODS FOR TREATING ANEURYSMS

The present invention relates to a stent including a variable porosity, tubular structure having pores defined by structural surfaces. The tubular structure has a low porosity region in proximity to or at either end of the tubular structure, where the low porosity region is less porous than other regions located on the tubular structure and fully or partially obstructs passage of fluid. Any arcuate path that starts at one point within the low porosity region and goes around the perimeter of the tubular structure to stop at the same point within the low porosity region must have at least a portion that is outside of the low porosity region. Also disclosed is a method of modifying blood flow within and near an opening of an aneurysm in a blood vessel by deploying one or more stents of the present invention near an opening of the aneurysm in a blood vessel.

STENT VASCULAR INTERVENTION DEVICE AND METHOD

The present invention relates to a stent including a variable porosity, tubular structure having pores defined by structural surfaces. The tubular structure has a low porosity region (6) on a path around the tubular structure, where the low porosity region is less porous than other regions (8) located on the path and fully or partially obstructs passage of fluid. The low porosity region (6) is larger than the structural surfaces (4) between adjacent pores (2). Also disclosed is a method of altering blood flow within and near an opening of a defective blood vessel involving deploying the above stent (600) of the present invention in a defective blood vessel (V) so that the low porosity region (602) is aligned to and in contact with an opening (O) in the defective blood vessel (V), thereby altering blood flow within and near the opening (O) of the defective blood vessel (V).

METHOD AND APPARATUS FOR SEALING AN OPENING IN THE SIDE WALL OF A BODY LUMEN

An expandable spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame configured to assume a collapsed configuration and an expanded configuration; and a closed face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the closed face is configured so as to obstruct flow therethrough.

IMPLANT INSERTION SYSTEM

The invention relates to a device for introducing an implant (1) into blood vessels or hollow organs of the human or animal body, comprising an implant (1), an insertion wire (14), and a transfer tube (13), wherein the implant (1) can be deformed in such a way that, in a micro-catheter (8), the implant assumes a form having a reduced diameter and, at the implantation location, following the removal of the external force by the micro-catheter (8), expands whilst adapting to the diameter of the blood vessel or hollow organ. A a holding element (2) is arranged on the insertion wire (14) and the holding element (2) has peripherally at least one, preferably multiple, grooves (3) let into the holding element (2), which extend on the circumference of the holding element (2) and form tracks in the form of curved lines. The implant (1) has at the proximal end at least one, preferably multiple, holding wires (5) extending in the proximal direction and fitted into the grooves (3), wherein the transfer ...

VESSEL SUPPORT DEVICE AND METHODS FOR SUPPORTING A VESSEL

The present invention is directed to a vessel support member having opposing ends adapted to move in a circumferential plane, the support member configured for deployment in a substantially radial direction to support a substantial portion of the circumference of a vessel, the support member adapted to change between a first configuration and at least a second configuration, such that when in the first configuration, the support member is substantially linear or substantially planar, and as the support member is deployed and changes to at least the second configuration, one opposing end moves in a radial direction relative to the other opposing end, such that when in the second configuration the support member is substantially non-linear or substantially prismatic with a curved portion or region. Also provided is a method of supporting, and a kit for providing support to, a human or animal vessel, and a deployment means for deploying a support member.

ENDOPROSTHESIS DEVICES AND METHODS OF USING THE SAME

Endoprosthesis assemblies and methods for using the same. In at least one embodiment, the endoprosthesis assembly comprises an endoprosthesis comprising an impermeable inner wall defining an endoprosthesis lumen sized and shaped to permit fluid to flow therethrough, a distal balloon positioned at or near a distal end of the endoprosthesis and capable of inflation to anchor the distal end of the endoprosthesis within a luminal organ, and a proximal balloon positioned at or near a proximal end of the endoprosthesis and capable of inflation to anchor the proximal end of the endoprosthesis within the luminal organ, wherein when the endoprosthesis assembly is positioned within the luminal organ at or near an aneurysm sac, inflation of the distal balloon and the proximal balloon effectively isolates the aneurysm sac and prevents fluid within the aneurysm sac from flowing past the distal balloon and the proximal balloon.

Flexible intra-vascular aneurysm treatment stent

An intra-vascular aneurysm-treatment stent and a method for lowering pressure within an aneurysm bubble in a blood vessel. A stent coil is insertable into a blood vessel, the coil made of a material sufficiently flexible to move around curves, loops, and corners in the blood vessel. Selected portions of the stent coil, in cross-section, have substantially convex outer surfaces, and either substantially flat, or substantially concave, inner surfaces, plus upstream leading edges and downstream trailing edges. The stent coil is positioned in the blood vessel with selected stent coil portions proximate an opening into either a saccular aneurysm or a fusiform aneurysm. Blood in the lumen of the blood vessel flows past the leading edges and both over the convex outer surfaces, and under the either flat or concave inner surfaces. A portion of the blood inside the aneurysm becomes entrained with the blood flowing over the outer surfaces. At the trailing edges, the converging blood flows create ...

STENT DELIVERY SYSTEM

A stent delivery system comprises a stent having a first connector disposed on a stent proximal end, and a pusher wire having a second connector disposed on a pusher wire distal end, wherein the first and second connectors are configured to releasably attach to each other.

Devices and methods for aneurysm treatment

The invention provides devices and methods for aneurysm treatment using a material that minimizes susceptibility artifacts in MRA images. Since images are not obscured by susceptibility artifacts associated with the aneurysm treatment device, those images are useful and reliable for evaluating the success of treatment. The material is preferably a non-ferromagnetic metal alloy and may include one or a combination of cobalt, nickel, chromium, and molybdenum. In certain embodiments, the material is a 35Cobalt-35Nickel-20Chromium-10Molybdenum-Low Titanium alloy medical-grade material.

System and method for delivering and deploying an occluding device within a vessel

A system and method for deploying an occluding device that can be used to remodel an aneurysm within the vessel by, for example, neck reconstruction or balloon remodeling. The system comprises an introducer sheath and an assembly for carrying the occluding device. The assembly includes an elongated flexible member having an occluding device retaining member for receiving a first end of the occluding device, a proximally positioned retaining member for engaging a second end of the occluding device and a support surrounding a portion of the elongated flexible member over which the occluding device can be positioned.

Membrane implant for treatment of cerebral artery aneurysms

The invention relates to a membrane implant (1) for treatment of cerebral artery aneurysms (10), wherein the implant can be implanted endovascularly into vessel segments (2) at the craniocerebral base of pathological (aneurysmatic) dilation (10) and, in combination with a stent, bridges the diseased vessel segment (2) from inside and disconnects it from the blood stream, wherein the membrane implant (1) comprises a biocompatible plastic membrane in the shape of a cylinder or a segment of a cylinder.

Systems and methods for magnetized stent having growth-promoting properties

Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm. The magnetic region can serve to attract and position both residual red blood cells and magnetically nano-treated growth-promoting cells to the orifice area of the aneurysm. The outer circumference of the tubular elongated body can act as a floor or scaffold for regenerated smooth vascular muscle cells. In embodiments, the tissue nidus area can be provided on the exterior stent, while the magnetized region is provided on the interior stent, of a stent-in-stent structure. In embodiments, the exterior stent is made of biodegradable material which gradually dissolves or dissipates in situ.

Monolithic medical devices, methods of making and using the same

The monolithic device comprises a plurality of scaffolding members and a mesh patterned members webbed between the scaffolding members; the mesh patterned member webbed between the scaffolding members surround a lumen and generally expands from a contracted state to an expanded state; and mesh patterned members including a plurality of openings traversing the thickness of the mesh patterned member, and the mesh patterned members including a surface on which a pattern of openings is formed.

HYBRID STENT

A stent includes a high radial/crush force segment and a highly flexible segment. In an aspect, a plurality of first ring struts connected such that each of the plurality of first rings comprises a sinusoidal pattern having a plurality of apices and troughs, each first ring connected to an adjacent first ring by at least one connector. The connector extends from a ring strut of the first ring from a position near an apex of the first ring to a ring strut of the adjacent first rings near an apex of the adjacent ring, and a second stent segment comprises a plurality of second rings connected to one another to form a series of second rings ...

Delivery system for a prosthesis

The invention provides a delivery system for a prosthesis, said delivery system comprising a catheter shaft with a distal end, a proximal end and a longitudinal axis, a space for a prosthesis with a distal end and a proximal end, the space being at the distal end of the catheter shaft, a sheath with a proximal end and a distal end, the sheath being disposed at the distal end of the catheter shaft so as to surround the space, a pusher element attached to the distal end of the catheter shaft and arranged at the proximal end of the space for abutting prosthesis, a pull element with a longitudinal axis, the pull element running the length of the catheter shaft and having a distal end attached to the proximal end of the sheath and a proximal end for pulling the pull element proximally, thereby retracting the sheath proximally relative to the prosthesis space, and at least one fixation element having a proximal end and a distal end and being disposed within a flexible portion of the length of ...

BIOABSORBABLE FLOW DIVERTING SCAFFOLD

This disclosure relates to scaffolds made of a braid of bioabsorbable polymeric fibers for implantation within a lumen of a mammalian body and, in particular, to such scaffolds that are configured to divert blood flow from a pathology associated with a blood vessel.

IMPLANTABLE GRAFT ASSEMBLY AND ANEURYSM TREATMENT

System for diverticulitis treatment

A system for preventing recurrence of diverticulitis includes a semi-permeable sleeve configured to be placed within a colonic lumen relative to one or more diverticulum lining the colonic lumen. The system also includes at least first and second collars disposed on opposing ends of the semi-permeable sleeve. The collars are configured to be selectively expanded radially outward to anchor the semi-permeable sleeve within the colonic lumen. The semi-permeable sleeve is configured to prevent permeation of undesirable material from within the colonic lumen into the at least one diverticulum and allow permeation of desirable material from the exterior of the semi-permeable sleeve into the colonic lumen.

KINK-RESISTANT STENT DEVICES AND RELATED METHODS

УСТРОЙСТВО ДЛЯ ЗАКРЫТИЯ АНЕВРИЗМЫ

Endovaskuläre-Vorrichtung zur Embolisierung eines Aneurysmas

Stent element

Implantable graft assembly and aneurysm treatment

An expandable tube for deployment within a blood vessel

MIX STENT

INTRAVASKULARER STENT FOR THE TREATMENT OF LESIONEN OF NEUROVASCULARER BLOOD VESSELS

ENDOLUMINALE DEVICE WITH AN ANCHORAGE UNIT

BIFURCATED STENT

Minimal surface area contact device for holding plaque to blood vessel wall

A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of focal elevating elements on its outer annular periphery for holding loose plaque under a spring or other expansion force against a blood vessel wall. The focal elevating elements are designed to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the intraluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.

Radially expandable stent featuring covering tip primarily for bifurcated arteryaneurysms

Endovascular prosthesis

Implant

The invention relates to an implant (1) for use in the occlusion of aneurysms (A) in blood vessels (Z) in the region of vascular ramifications (X, Y), in particular bifurcation aneurysms, wherein the implant (1) is present in an expanded state in which the implant is implanted in the blood vessel (Z) and in a contracted state in which the implant is movable through the blood vessel (Z). The implant (1) has a proximal fixing section (3), by which the implant (1) can be fixed to a vessel wall of the blood vessel (Z), a distal section (5), in which the implant (1) is radially expanded in relation to the fixing section (3) and which is intended for positioning in or before the aneurysm (A), and a transition section (4) between the fixing section (3) and the distal section (5). The implant (1) is made up of filaments (10) which are connected to one another or intersect, and in the transition section (4) one or more filaments (10) coming from the fixing section (3) or distal section (5) come ...

ENDOVASCULAR PROSTHESIS AND DELIVERY DEVICE

Abstract In one of its aspects, the present invention relates to an endovascular prosthesis. The endovascular prosthesis comprises a first expandable portion expandable from a first, unexpanded state to a second, expanded state to urge the first expandable portion against a vascular lumen and a retractable leaf portion attached to the first expandable portion. The retractable leaf portion comprises at least one spine portion and a plurality of rib portions attached to the spine portion. Longitudinally adjacent pairs of rib portions are free of interconnecting struts. The endovascular prosthesis that can be unsheathed and re sheathed for repositioning of the endovascular prosthesis prior to final deployment thereof. There is also described a delivery device that is particularly well suited to delivering the present endovascular prosthesis through tortuous vasculature in the body. 8932143 1 (GHMatters) P95331.AU.1 * m ,r7i cn ...

VARIABLE POROSITY INTRA VASCULAR IMPLANT MANUFACTURING METHOD

A vascular occlusion device for effectively occluding blood flow and pressure to a vascular defect while simultaneously not occluding blood flow and pressure to adjacent vasculature is provided. The vascular occlusion device can include a tubular member that has variable porosity regions along its length. The tubular member can be formed of a plurality of filaments that have different cross-sectional shapes along their length that are indexed to the variable porosity regions along the length of the tubular member.

Delivery of medical devices

DELIVERY OF MEDICAL DEVICES A stent delivery system (100) can include an elongate core member (160) sized for insertion into a blood vessel (102). The core member (160) can be configured to advance a stent (200) toward a treatment location in the blood vessel (102). The core member (160) can include a longitudinally extending tube (170) having a helical cut extending along the tube (170). The helical cut can have an axial length of at least 50 cm and be continuous along the axial length.

Three-dimensional thin-film nitinol devices

A method of manufacturing three-dimensional thin-film nitinol (NiTi) devices includes: depositing multiple layers of nitinol and sacrificial material on a substrate. A three-dimensional thin-film nitinol device may include a first layer of nitinol and a second layer of nitinol bonded to the first layer at an area masked and not covered by the sacrificial material during deposition of the second layer.

IMPROVED MODIFIABLE OCCLUSION DEVICE

An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a pre-established pore features and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material associated with the pore features which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel. 50 ~~5~2 P V ...

BLOCKSTENT DEVICE AND METHODS OF USE

Examiner's Abstract for AU2020200482 A medical device for occluding an artery or a vein, the medical device comprising: a compressed, hollow structure, wherein the structure, when expanded, comprises a single lobe, having a wall comprising a polymer layer and a metal layer, the wall defining an interior surface further defining a void, and an exterior surface, with an opening in the wall that allows for the passage of fluid into the void, and wherein the passage of fluid into the void of the hollow structure results in expansion of the hollow structure; and wherein the expanded hollow structure has sufficient rigidity to remain in an expanded state when implanted in vivo in an unsealed configuration.

Devices for assisting medical treatments

A treatment device and method for treatment are provided. The treatment device can include a shaft, an expandable member, a first elongated control member and a second elongated control member. The expandable member can further include at least a first controllable portion and a second controllable portion, where the expandable member, including the first controllable portion and the second controllable portion, is configured to transition between at least a partially retracted configuration and an expanded configuration under control of at least the first elongated control member. Further still, the first controllable portion can be configured to transition between at least a partially retracted configuration and an expanded configuration, while the second controllable portion is configured to remain substantially unchanged, under control of at least the second elongated control member.

Vascular treatment devices and methods

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

INTRAVASCULAR STENT AND METHOD OF TREATING NEUROVASCULAR VESSEL LESION

A graftless prosthetic stent for treatment of vascular lesions such as aneurysms and arterio-venous fistulas, especially in neurovascular vessels, comprises a continuous helical ribbon formed of a shape-retaining metal having a transition temperature at which the stent expands from its contracted condition to a radially expanded condition, the stent remaining substantially cylindrical in its contracted and expanded conditions. The helical windings have variable width, thickness, number or size of openings, or combinations of these features, which affect the stiffness, rate of expansion at the transition temperature, and the area of vessel wall covered by the stent. Methods of treatment using the device are provided.

HYBRID STENT

A stent (10) comprises a plurality of segments, including at least one segment (100) which is in the form of a coil and at least one segment (90) which is in a form other than a coil and which is balloon expandable or self-expandable.

SYSTEMS AND METHODS OF MANUFACTURING AND USING AN EXPANSION RING

A method of connecting an expansion ring to at least one end of a braided implant is disclosed. The method can include positioning the braided implant about a tube; everting an end portion of the braided implant over a first end of the tube; assembling an expansion ring to the braided implant, the expansion ring being a multi-leaved expansion ring including clips terminating with an open-ended coupling opening. The openings can be pushed over a set of intersecting wires of the braided implant at respective circumferential locations on or adjacent the first end of the tube. The method can also include closing the openings over the set of intersecting wire; trimming ends of the braided implant; and reversing eversion of the braided implant thereby positioning the expansion ring internal to the braided implant.

A MEDICAL DEVICE

A medical device (10) for insertion into a bodily vessel (6) to treat an aneurysm (5) having an aneurysm neck, the device (10) comprising: a mechanically expandable device (20) expandable from a first position to a second position, said mechanically expandable device (20) is expanded radially outwardly to the second position such that the exterior surface of said mechanically expandable device (20) engages with the inner surface of the vessel (6) so as to maintain a fluid pathway through said vessel (6); a therapeutically effective amount of a chemical compound comprising a biosynthesis accelerator to stimulate cell growth; and a polymer (30, 41, 42) mixed with the chemical compound to manage the release rate of the chemical compound; wherein the mechanically expandable device (20) provides a support for the release of the chemical compound within the aneurysm (5) to stimulate cell growth within the aneurysm (5) and close the aneurysm neck.

Venous nitinol embolization inserts

A venous nitinol embolization insert for restricting blood flow includes a tubular member and an embolization material attached to the tubular member. The embolization insert provides a predetermined blood flow rate based on experimental data. A method of controlling restriction of blood flow to a targeted vascular site within a patient's body includes selecting an insert that provides a predetermined blood flow rate corresponding to a desired blood flow rate. The embolization insert is selected from a plurality of embolization inserts that provide varied blood flow rates.

Biodegradable endoprostheses and methods for their fabrication

Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

Vascular remodeling device

Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.

Devices and methods for treatment of vascular aneurysms

The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In a first embodiment of the present invention, a two part prostheses, where one part is an expandable sponge structure and the other part is an expandable tubular mesh structure, is provided. In the first embodiment, the expandable sponge structure is intended to fill the aneurysm cavity to prevent further dilatation of the vessel wall by creating a buffer or barrier between the pressurized pulsating blood flow and the thinning vessel wall. In the first embodiment, the expandable tubular mesh structure is placed across the aneurysm, contacting the inner wall of healthy vessel proximal and distal to the aneurysm.

Protuberant Aneurysm Bridging Device and Method of Use

A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Devices and methods for treatment of vascular aneurysms

The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In a first embodiment of the present invention, a two part prostheses, where one part is an expandable sponge structure and the other part is an expandable tubular mesh structure, is provided. In the first embodiment, the expandable sponge structure is intended to fill the aneurysm cavity to prevent further dilatation of the vessel wall by creating a buffer or barrier between the pressurized pulsating blood flow and the thinning vessel wall. In the first embodiment, the expandable tubular mesh structure is placed across the aneurysm, contacting the inner wall of healthy vessel proximal and distal to the aneurysm.

VASCULAR REMODELING DEVICE

Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection. 1. An intraluminal device comprising:a proximal section configured to anchor in an afferent vessel;an intermediate section comprising a plurality of struts configured to allow perfusion to efferent vessels;a distal section configured to act as a scaffolding to inhibit herniation of objects out of a neck of a bifurcation aneurysm;wherein each of the plurality of struts is coupled to the distal section at a coupling at a region between a proximal end of the distal section and a distal end of the distal section;wherein the distal section is biased to transition from a compressed state to a radially expanded state when released from a catheter, wherein, while transitioning from the compressed state to the radially expanded state, the distal end moves radially outwardly and proximally relative to the proximal section, and the proximal end of the distal section moves radially inwardly and distally relative to the proximal section.2. The intraluminal device of claim 1 , wherein claim 1 , while in the expanded state claim 1 , the proximal end and the distal end are substantially ...

METHODS AND SYSTEMS FOR INCREASING A DENSITY OF A REGION OF A VASCULAR DEVICE

A vascular device is provided that includes a mesh structure formed of a plurality of spaced members. The structure has (i) a first, collapsed configuration, (ii) a second, expanded configuration, and (iii) a density of the plurality of members. The vascular device further includes an elastic member disposed along a region of the structure, the region having a proximal end and a distal end. The elastic member is configured to increase the density within the region by drawing at least one of the proximal and distal ends of the region toward the other of the proximal and distal ends when the structure is in the second configuration. 1. A vascular device , comprising:a mesh structure formed of a plurality of spaced members, the structure having (i) a first, collapsed configuration, (ii) a second, expanded configuration, and (iii) a density of the plurality of members; andan elastic film disposed along a region of the structure, the region having a proximal end and a distal end, wherein the elastic film is configured to increase the density within the region by drawing at least one of the proximal and distal ends of the region toward the other of the proximal and distal ends when the structure is in the second configuration.2. The vascular device of claim 1 , wherein the elastic film is disposed on at least one of an inner surface and an outer surface of the structure.3. The vascular device of claim 1 , wherein the elastic film comprises a plurality of pores configured to permit blood to flow therethrough.4. The vascular device of claim 3 , wherein the pores are sized between about 70-200 microns.5. The vascular device of claim 1 , wherein the elastic film is configured to decrease the length of the region by about 10%-40% in the second configuration.6. The vascular device of claim 1 , wherein the elastic film is configured to allow tissue overgrowth thereon.7. The vascular device of claim 1 , wherein the elastic film forms a substantially cylindrical shape.8. The ...

Stent

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

Delivery of medical devices

A stent delivery system can include a core member, an introducer sheath, and a microcatheter. The core member can have a distal segment. The stent engagement member can have a generally tubular body positioned about the core member distal segment and can be rotatably coupled to the core member. The engagement member can include an inner layer that has a first durometer and an outer layer that has a second durometer less than the first durometer. The stent can extend along the core member distal segment such that an inner surface of the stent is engaged by the engagement member outer layer for facilitating rotation of the stent relative to the core member.

METHODS AND DEVICES FOR TREATMENT OF VASCULAR DEFECTS

Devices for treatment of a patient's vasculature are described. The device includes a first hub, a second hub, a support structure including a plurality of struts disposed between the first hub and the second hub, and a layer of material disposed over the plurality of struts. The support structure has a low profile, radially constrained state with an elongated tubular configuration suitable for delivery from a microcatheter. The support structure also has an expanded state, a smooth outer surface, and has an axially shortened configuration relative to the radially constrained state. The layer of material may be made from acrylic, silk, silicone, polyvinyl alcohol, polypropylene, polyester, PolyEtherEther Ketone (PEEK), polytetrafluoroethylene (PTFE), polycarbonate urethane (PCU), or polyurethane (PU). The support structure may be formed from a slotted tubular member. 1. A device for treatment of a patient's vasculature comprising:a first hub;a second hub;a support structure having a longitudinal axis and disposed between the first hub and the second hub, the support structure including a plurality of struts; anda layer of material disposed over the plurality of struts,wherein the support structure has a low profile, radially constrained state with an elongated tubular configuration having a transverse dimension, the radially constrained state having a low profile suitable for delivery from a microcatheter, andwherein the support structure also has an expanded state having a first end, a second end, and a smooth outer surface and having an axially shortened configuration relative to the radially constrained state.2. The device of claim 1 , wherein the layer of material comprises at least one of acrylic claim 1 , silk claim 1 , silicone claim 1 , polyvinyl alcohol claim 1 , polypropylene claim 1 , polyester claim 1 , PolyEtherEther Ketone (PEEK) claim 1 , polytetrafluoroethylene (PTFE) claim 1 , polycarbonate urethane (PCU) and polyurethane (PU).3. The device of claim ...

SYSTEMS FOR DIAGNOSING AND/OR TREATING MEDICAL CONDITIONS

A method for performing a diagnostic or therapeutic procedure on a partial occlusion within a blood vessel, includes positioning a guide having a sensor configured and adapted to measure at least one of pressure, volume or flow within a blood vessel, advancing the guide through an at least partial occlusion within the blood vessel such that the sensor is downstream of the occlusion, measuring at least one of pressure, volume or flow downstream of the occlusion using the sensor and analyzing data obtained from the sensor to assist in determining the viability of tissue of the blood vessel downstream of the occlusion. 1. A method for performing a diagnostic or therapeutic procedure on an occlusion within a blood vessel , the method comprising:positioning a guide having a sensor configured and adapted to measure at least one of pressure, volume or flow within a blood vessel;advancing the guide through an at least partial occlusion within the blood vessel such that the sensor is downstream of the occlusion;measuring at least one of pressure, volume or flow downstream of the occlusion using the sensor; andanalyzing data obtained from the sensor to assist in determining the viability of tissue of the blood vessel downstream of the occlusion.2. The method according to including determining a surgical protocol based on analyzing the data.3. The method according to including obtaining a CT scan of the blood vessel and/or the occlusion wherein determining the surgical protocol includes reviewing the CT scan.4. The method according to including treating the occlusion.5. The method according to wherein treating the occlusion includes at least one of introducing a thrombectomy device to remove the occlusion claim 4 , initiating drug therapy to treat the occlusion or implanting a flow diverter adjacent the occlusion.6. The method according to wherein measuring at least one of pressure claim 4 , volume or flow downstream of the occlusion using the sensor is also performed ...

Occlusive Device

An aneurysm embolization device can include a body having a single, continuous piece of material that is shape set into a plurality of distinct structural components. For example, the device can have an expandable component and an atraumatic tip portion extending therefrom. Further, the tip portion can be configured to enable the device to be implanted within the aneurysm while tending to mitigate risk of puncturing the aneurysm dome or otherwise assist in framing the aneurysm in advance of placement of additional embolic material.

VASCULAR DEVICE FOR ANEURYSM TREATMENT AND PROVIDING BLOOD FLOW INTO A PERFORATOR VESSEL

A vascular device includes a body having a first, collapsed configuration and a second, expanded configuration. The body includes a plurality of heat-set strands that are braided such that when the body is in the second configuration, the strands form a plurality of pores and one or more apertures between the strands. The apertures are generally disposed at a longitudinal center region of the body. When the body is in the second configuration, the pores at proximal and distal portions of the body are generally uniform in size and smaller in size than the apertures. The pores and the apertures are substantially the same size when the body is in the first configuration. 1. A method , comprising:positioning, at a target location within a blood vessel, a vascular device having a body in a first, collapsed configuration with the body comprising braided strands forming pores and apertures between the strands, the pores and the apertures being substantially the same size as each other in the first, collapsed configuration; andexpanding the body from the first, collapsed configuration to a second, expanded configuration with the apertures being disposed at a longitudinally central section of the body, the pores being disposed at longitudinally proximal and distal sections of the body, and the pores being generally uniform in size and smaller in size than the apertures in the second, expanded configuration;wherein a number of strands in each of the proximal, central, and distal sections of the body is the same.2. The method of claim 1 , wherein central regions of the apertures are disposed along a single radial cross section of the body.3. The method of claim 2 , wherein the body has a hoop strength that is generally uniform along a longitudinal length of the body.4. The method of claim 1 , wherein the body has a hoop strength that is generally uniform along a longitudinal length of the body.5. The method of claim 1 , wherein the expanding comprises aligning at least one of ...

STENT WITH EXPANDABLE FOAM

A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure. 1. A system comprising:a first shape memory polymer (SMP), the first SMP including a first SMP foam;a second SMP, the second SMP including a second SMP foam;wherein the first SMP foam: (a)(i) is an open cell foam, (a)(ii) is biodegradable, (a)(iii) includes a first channel, and (a)(iv) includes two or more members selected from the group comprising Hexamethylene diisocyanate (HDI), triethanolamine (TEA), or hydroxypropyl ethylenediamine (HPED);wherein the second SMP foam: (b)(i) is cylindrical, (b)(ii) includes a second channel, and (b)(iii) is included in the first channel; andwherein: (c)(i) the first SMP foam is in a first state; and (c)(ii) the first SMP foam is configured to expand to a second state, radially outward from the second SMP foam, in response to thermal stimulus.2. The system of wherein:{'sub': 'g', 'the first SMP foam has a glass transition temperature (T) between 30° C. and 86° C.;'}the first SMP foam is cross-linked; andthe first SMP foam is configured to have, in the second state, a volumetric void fraction greater than 98% and less than 100%.3. The system of comprising a third SMP claim 2 , wherein the third SMP is between the first and second SMP foams.4. The system of wherein the third SMP includes a stent having a first strut that includes the third SMP and a second strut that includes the third SMP.5. The system of comprising a fourth SMP claim 3 , wherein:the third SMP is between the fourth SMP and the second SMP;the second SMP is not monolithic with the first SMP;the second SMP is not monolithic with the third SMP;the fourth SMP is not monolithic with the second SMP;the fourth SMP is cured.6. The system of comprising a third SMP claim 2 , wherein:the second SMP foam is between the third SMP and the first SMP foam;the third SMP is cured and the ...

FLEXIBLE STENT WITH NON-BONDED STENT COVER MATERIAL REGIONS

A prosthesis is provided for a variety of medical treatments. The prosthesis may include an expandable tubular frame structure and a covering disposed along the frame structure. A proximal liner may be situated along a proximal end of the frame, a distal liner may be situated along a distal end of the frame, and an intermediate liner may be between the proximal liner and the distal liner along the frame. The intermediate liner comprises an extended layer that meets and bonds to the proximal liner and the distal liner at their respective ends. A method of manufacturing the prosthesis is also provided. 1. A prosthesis comprising:an expandable tubular frame structure having a proximal frame end and a distal frame end;a covering disposed along the frame structure, the covering including a first liner, a proximal liner, and a distal liner discrete from the proximal liner, the first liner comprising a plurality of first liner layers, wherein at least one of the first liner layers is an extended layer extending beyond a proximal end of the remaining first liner layers and a distal end of the remaining first liner layers of the first liner,wherein a proximal end of the extended layer is bonded to the proximal liner along the proximal frame end at a first coupling segment, and a distal end of the extended layer is bonded to the distal liner along the distal frame end at a second coupling segment, andwherein one of the first liner layers immediately adjacent to the expandable tubular frame structure remains unbonded to the expandable tubular frame structure along an intermediate region of the frame structure disposed between the proximal and distal frame ends.2. The prosthesis of claim 1 , wherein the first and second coupling segments have a common wall thickness claim 1 , and an intermediate segment of the first liner that remains unbonded to the expandable tubular frame structure comprises a wall thickness sized the same as the common wall thickness.3. The prosthesis of ...

DEVICES AND METHODS FOR TREATMENT OF VASCULAR ANEURYSMS

The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In a first embodiment of the present invention, a two part prostheses, where one part is an expandable sponge structure and the other part is an expandable tubular mesh structure, is provided. In the first embodiment, the expandable sponge structure is intended to fill the aneurysm cavity to prevent further dilatation of the vessel wall by creating a buffer or barrier between the pressurized pulsating blood flow and the thinning vessel wall. In the first embodiment, the expandable tubular mesh structure is placed across the aneurysm, contacting the inner wall of healthy vessel proximal and distal to the aneurysm. 1. A system for treating an aneurysm comprising:a catheter delivery system having a distal tip; anda filler passable through the distal tip, wherein when the filler is in a deployed configuration, the filler is between a first leg of a bifurcated stent and a wall of the aneurysm, and wherein when the filler is in the deployed configuration, the filler is between a second leg of the bifurcated stent and the wall of the aneurysm.2. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , the filler contacts the first and second legs of the bifurcated stent.3. The system of claim 2 , wherein when the filler is in the deployed configuration claim 2 , the filler contacts the wall of the aneurysm.4. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , the filler contacts the wall of the aneurysm.5. The system of claim 4 , wherein when the filler is in the deployed configuration claim 4 , the filler contacts at least one of the first and second legs of the bifurcated stent.6. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , a portion of the filler is between ...

DEVICES AND METHODS FOR TREATMENT OF VASCULAR ANEURYSMS

The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In one embodiment, a system for treating an aneurysm is disclosed. The system comprises a catheter delivery system, an expandable foam configured to pass through the catheter delivery system, and a stent having a first end and a second end. The stent is configured to extend across the aneurysm. The expandable foam is configured to expand in the aneurysm when exposed to a fluid. 1. A system for treating an aneurysm comprising:a catheter delivery system having a distal tip; anda filler passable through the distal tip into a first fillable space and into a second fillable space, wherein when the filler is in a deployed configuration, the filler is in the first and second fillable spaces, and wherein the first fillable space is at a proximal end of the aneurysm and the second fillable space is at a distal end of the aneurysm.2. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , the ii first fillable space and the second fillable space are separate from each other.3. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , the first fillable space is connected to the second fillable space.4. The system of claim 1 , wherein before the filler is deployed claim 1 , the first fillable space is separate from the second fillable space.5. The system of claim 4 , wherein after the filler is deployed claim 4 , the first fillable space is connected to the second fillable space.6. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , the filler is a continuous structure.7. The system of claim 1 , wherein when the filler is in the deployed configuration claim 1 , the filler contacts two distal legs of a bifurcated stent.8. The system of claim 7 , wherein when the filler is in the ...

STENT WITH EXPANDABLE FOAM

A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure. 1a first shape memory polymer (SMP), the first SMP including a SMP foam;a second SMP;wherein the SMP foam: (a)(i) is an open cell foam, (a)(ii) is biodegradable, (a)(iii) includes a first channel, and (a)(iv) includes a reaction product of a diisocyanate, triethanolamine (TEA), and hydroxypropyl ethylenediamine (HPED);wherein the second SMP: (b)(i) is a cylindrical stent having a first strut that includes the second SMP and a second strut that includes the second SMP, (b)(ii) includes a second channel, and (b)(iii) is included in the first channel;wherein: (c)(i) the SMP foam is in a first state; and (c)(ii) the SMP foam is configured to expand to a second state, radially outward from the second SMP, in response to thermal stimulus;wherein the first SMP is crimped and the second SMP is crimped;wherein the SMP foam has a glass transition temperature (Tg) between 30° C. and 86° C.;wherein the SMP foam is a thermoset polyurethane polymer;wherein the first SMP is coupled to a wire and the second SMP is coupled to the wire.. A system comprising: This application is a Continuation of U.S. patent application Ser. No. 16/139,365, filed Sep. 24, 2018, which is a Continuation of U.S. patent application Ser. No. 14/797,973, filed Jul. 13, 2015, entitled “Stent with Expandable Foam”, which issued on Sep. 25, 2018 as U.S. Pat. No. 10,080,642, which is a Continuation of U.S. patent application Ser. No. 13/892,492, filed May 13, 2013, entitled “Stent with Expandable Foam”, which issued on Jul. 14, 2015 as U.S. Pat. No. 9,078,738, which is a continuation of U.S. patent application Ser. No. 13/010,055, filed Jan. 20, 2011, entitled “Stent with Expandable Foam”, which issued on May 28, 2013 as U.S. Pat. No. 8,449,592, which is a Continuation-in-Part of U.S. patent application Ser. No. 11/ ...

METHOD FOR TREATING ARTERIAL STENOSIS

Disclosed herein is a method of treating a subject having arterial stenosis. The method comprises: (a) providing a plurality of image frames of an artery of the subject taken in sequence; (b) in a plurality of cross-sections of the artery, determining a maximum diameter and a minimum diameter of each of the plurality of cross-sections of the artery among the plurality of image frames of the step (a); (c) calculating an average vasodilation ratio of the artery base on the maximum diameter and the minimum diameter determined in the step (b); and (d) treating the subject based on the average vasodilation ratio calculated in the step (c), by implanting a stent to the subject when the average vasodilation ratio is equal to or greater than 0.2; or administering to the subject an effective amount of a vasodilator when the average vasodilation ratio is less than 0.2. 1. A method of treating a subject having arterial stenosis , comprising ,(a) providing a plurality of image frames of an artery of the subject taken in sequence;(b) in a plurality of cross-sections of the artery, determining a maximum diameter and a minimum diameter of each of the plurality of cross-sections of the artery among the plurality of image frames of the step (a);(c) calculating an average vasodilation ratio of the artery base on the maximum diameter and the minimum diameter of each of the plurality of cross-sections of the artery determined in the step (b); and 'implanting a stent to the subject when the average vasodilation ratio is equal to or greater than 0.2.', '(d) treating the subject based on the average vasodilation ratio calculated in the step (c) by'}2. The method of claim 1 , wherein in the step (b) claim 1 , the maximum diameter and the minimum diameter are determined by the steps of claim 1 ,(i) determining a boundary and a central axis of the artery via aligning each of the plurality of image frames;(ii) selecting the plurality of cross-sections in the artery according to the normal ...

Flexible vascular occluding device

A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain. The neurovascular occluding device can be deployed using a micro-catheter. The occluding device can be formed by braiding wires in a helical fashion and can have varying lattice densities along the length of the occluding device. The occluding device could also have different lattice densities for surfaces on the same radial plane.

MEDICAL DEVICE, IN PARTICULAR A FLOW DIVERTER, AND KIT

The invention concerns a medical device, in particular a flow diverter, having a radially self-expandable lattice structure () which is tubular at least in some regions and which is composed of a plurality of interwoven individual wires () which form meshes () of the lattice structure (), wherein at least some of the individual wires () have an X-ray visible core material () and a superelastic mantle material (), wherein a plurality of directly adjacent meshes () in the circumferential direction of the lattice structure () form a mesh ring (), wherein in a fully self-expanded state, the lattice structure () has an expansion diameter D, the mesh ring () has a mesh number n, and the core material () has a core diameter d, and wherein for the core diameter d, the following holds: 2. The medical device as claimed in claim 1 ,characterized in that{'sub': 'exp', '#text': 'the expansion diameter Dis 2.5 mm to 8 mm.'}3. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': '10', '#text': 'a braiding angle α of the lattice structure () is between 70° and 80°, in particular 75°.'}4. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': '11', 'sub': 'wire', 'claim-text': [{'sub': ['exp', 'wire'], '#text': 'in the case of an expansion diameter Dof 2.5 mm to 4.5 mm: 30 μm≤d≤46 μm, and'}, {'sub': ['exp', 'wire'], '#text': 'in the case of an expansion diameter Dof more than 4.5 mm to 8 mm: 46 μm≤d≤65 μm.'}], '#text': 'the wire () has a wire diameter d, which is'}5. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': '11', 'i': 'b', '#text': 'the mantle material () of the wire has a thickness which is at least 10 μm, in particular at least 15 μm, in particular 10 μm to 20 μm.'}6. The medical device as claimed in one of the preceding claims claim 1 ,characterized in that{'b': ['11', '11'], 'i': 'a', '#text': 'the volume of the core material () takes up a ...

VASCULAR PROSTHESIS WITH SIDE BRANCHES

The present invention relates a vascular prosthesis for a blood vessel of a patient, which has the following: a hollow-cylindrical main body with a main lumen extending therein, an also a multiplicity of stent rings, which are not connected to one another, are arranged spaced apart one behind the other in the longitudinal direction of the vascular prosthesis and running around in a meandering formation. The vascular prosthesis also has four side branches, which extend distally into the main lumen from fenestrations in the prosthesis material lying between the stent rings. 1. A vascular prosthesis for a blood vessel of a patient , which has the following:{'b': 1', '2', '3, 'a hollow-cylindrical main body with a longitudinal axis (L), a proximal opening and a distal opening, and also a main lumen extending between the proximal opening and the distal opening, the main body having a proximal end portion and a distal end portion, which respectively comprise the proximal opening or the distal opening, and also a middle portion arranged between the proximal end portion and the distal end portion, the proximal end portion, the middle portion, and the distal end portion each having diameters d, d, and d, respectively,'}a plurality of stent rings, which are not connected to one another, the stent rings being arranged spaced apart one behind the other in the longitudinal direction of the vascular prosthesis and running around in a meandering formation, the stent rings respectively having ogives and webs connecting them,a prosthesis material, to which the stent rings are attached, and{'b': 2', '1', '3, "four side branches, which extend, from fenestrations in the prosthesis material lying between the stent rings, into and within the main lumen towards the distal opening, each side branch having a first side-branch opening and a second side-branch opening and also a side-branch lumen extending between the first side-branch opening and the second side-branch opening, the first ...

Kink-resistant stent devices and related methods

A device includes an elastic tubular stent including struts forming closed cells arranged in rows along a circumferential direction of the stent, with each cell having a first obtuse-angled corner on one end of the cell along a longitudinal direction of the stent and a second obtuse-angled corner on an opposing end of the cell along the longitudinal direction. The stent may be fabricated by cutting an array of quadrilateral cells in a nitinol hypotube to form a stent, with each cell having four corners with approximately equal angles. The stent may then be expanded radially such that each cell has a first obtuse-angled corner on one end of the cell along a longitudinal direction of the stent and a second obtuse-angled corner on an opposing end of the cell along the longitudinal direction, and heat treated to fix the shape of the stent.

Thin-film micromesh and related methods

Thin-film mesh for medical devices and related methods are provided. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh may be used as a cover for a stent device. The thin-film mesh has a tube-shape and the slits may be angled with respect to a longitudinal axis of the tube-shape thin-film mesh. The angled slits allow for the thin-film mesh to expand in multiple dimensions, including along the longitudinal axis and along the circumferential direction of the tube-shape thin-film mesh. The slits may be provided in diagonal rows arranged in longitudinal columns. Longitudinal columns of different types of slits may be arranged along the circumferential direction on the tube-shape thin-film mesh to form a zig-zag pattern of slits. The thin-film mesh may be formed from thin-film Nitinol (TFN) and may be fabricated via sputter deposition on a micropatterned wafer.

Stent

A stent with varying porosity is described. The stent can be comprised of multiple stents attached together. A braided stent may have selected regions of increased thickness. The stent may be comprised of wires that are welded together at their ends in order to minimize vessel trauma. The stent may comprise a helically wound radiopaque wire wound through the stent.

Wing Bifurcation Reconstruction Device

An intraluminal device may be used at a bifurcation to anchor in an afferent vessel, allow perfusion to efferent vessels, and act as scaffolding to inhibit herniation of objects out of a neck of a bifurcation aneurysm. An intraluminal device may include a first side; a second side opposite the first side across a longitudinal axis of the intraluminal device; a proximal section configured to anchor in an afferent vessel; a distal section comprising a first wing and a second wing wherein, in an expanded state, the first wing extends from the first side to the second side and the second wing extends from the second side, through an opening of the first wing, and to the first side. 1. A method of delivering an intraluminal device comprising:positioning the intraluminal device within a body vessel while in a compressed state, the intraluminal device comprising (i) a proximal section, (ii) a distal section having (a) a first wing including first base struts connected to each other by a first end strut and (b) a second wing including second base struts connected to each other by a second end strut, and (iii) at least two junctures between the proximal section and the distal section, wherein the first wing and the second wing are fixedly connected to each other only at the at least two junctures;expanding the intraluminal device from the compressed state to an expanded state in which (i) the first base struts extend from different ones of the at least two junctures and along a first side of the distal section and the first end strut is on a second side of the distal section, substantially opposing the first side, (ii) the second wing extends through an opening in the first wing, and (iii) the second base struts extend from different ones of the at least two junctures and along the second side and the second end strut is on the first side.2. The method of claim 1 , wherein the intraluminal device is positioned within the body vessel while within a sheath claim 1 , and ...

Stent

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer. 1. An implant device comprising:a first woven cylindrical layer having a first porosity; said first woven cylindrical layer being formed from a single first wire crossing back and forth between a first end and a second end of said first woven cylindrical layer at a plurality of locations to form said first generally cylindrical shape with a plurality of loops at said first end and said second end; and,a second woven cylindrical layer having a second porosity, forming a second generally tubular shape, and located within said first generally tubular shape; said second woven layer being formed from one or more wires.2. The implant device of claim 1 , wherein said single first wire comprises a plurality of reduced diameter regions.3. The implant device of claim 2 , wherein said plurality of reduced diameter regions are positioned along said first wire at overlapping wire positions.4. The implant device of claim 2 , wherein said plurality of reduced diameter regions are positioned along said single first wire at overlapping wire positions when said implant device is in an expanded configuration claim 2 , so as to decrease a thickness of said implant device.5. The implant device of claim 2 , wherein said plurality of reduced diameter regions are positioned along said first wire at overlapping wire positions when said implant device is in a compressed configuration claim 2 , so as to decrease a thickness of said implant device.6. The implant device of claim 2 , wherein said reduced diameter regions are caused by electropolishing or etching.7. The implant device of claim 2 , ...

Stent and Catheter Systems for Treatment of Unstable Plaque and Cerebral Aneurysm

The invention generally relates to co-axial stent and catheter systems and medical procedures utilizing these systems. The co-axial stent system is characterized by two-coaxial stents, including an outer resorbable stent and an inner metal stent used to effect deployment of the resorbable stent. The stents may use for treatment of unstable plaque and/or thrombus at the carotid bifurcation and particularly those that are not causing any significant stenosis. The stents may also be used for treatment of cerebral aneurysms. The invention further describes related, equipment, uses and kits for the treatment of unstable plaque and/or thrombus and/or aneurysms. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. A kit for the treatment of an unstable plaque or an aneurysm at a desired location in a patient , the kit comprising:at least one guide catheter (GC) adapted for placement proximal to the desired location;at least one guide wire adapted for placement distal to the desired location;at least one microcatheter adapted for placement distal to the desired location over the guide wire;at least one resorbable stent (RS) assembly adapted for placement adjacent to the desired location and deployable through the at least one microcatheter each RS assembly having a RS adapted to stabilize the unstable plaque or aneurysm for a therapeutically effective time period and resorbable into the patient over a resorb time.19. The kit as in where the GC is at least one balloon guide catheter (BGC) for occluding blood flow.20. The kit as in further comprising at least one micro-balloon (MB) for occluding blood flow through the ECA.21. The kit as in where the kit includes at least two resorbable stent assemblies each having a resorbable stent claim 18 , and where the resorbable stents have at least one ...

DELIVERY OF MEDICAL DEVICES

A stent delivery system can include a core member, an introducer sheath, and a microcatheter. The core member can have a first section and a second section distal to the first section. The second section can have a bending stiffness per unit length that is less than a bending stiffness per unit length of the first section. The introducer sheath can have a lumen configured to receive the core member therethrough. The introducer sheath can have a length of at least about 80 cm. The microcatheter can have a lumen and a proximal end configured to interface with a distal end of the introducer sheath for delivering the core member into the microcatheter lumen. 1an elongate core member sized for insertion into a blood vessel, the core member configured for advancing a stent toward a treatment location in the blood vessel, the core member comprising a longitudinally extending tube having a helical cut extending along the tube, the helical cut having an axial length of at least 50 cm and being continuous along the axial length.. A stent delivery system, comprising: This application is a continuation of U.S. patent application Ser. No. 14/040,477, filed Sep. 27, 2013, which claims the benefit of U.S. Provisional Patent Application No. 61/870,755, filed Aug. 27, 2013. The entirety of each of these applications is incorporated herein by reference.Walls of the vasculature, particularly arterial walls, may develop areas of pathological dilatation called aneurysms. As is well known, aneurysms have thin, weak walls that are prone to rupturing. Aneurysms can be the result of the vessel wall being weakened by disease, injury, or a congenital abnormality. Aneurysms could be found in different parts of the body, and the most common are abdominal aortic aneurysms and brain or cerebral aneurysms in the neurovasculature. When the weakened wall of an aneurysm ruptures, it can result in death, especially if it is a cerebral aneurysm that ruptures.Aneurysms are generally treated by excluding ...

THIN FILM MESH HYBRID FOR TREATING VASCULAR DEFECTS

Devices that can be delivered into a vascular system to divert flow are disclosed herein. According to some embodiments, devices are provided for treating aneurysms b diverting flow. An expandable device can comprise, for example, a plurality of strut regions and a plurality of bridge regions. Each of the strut regions may extend circumferentially about the expandable device and include a plurality of struts. Each of the plurality of bridge regions may be attached to and extend between two of the strut regions and comprise a plurality first bridges and second bridges that intersect one another and are movable relative to one another at their intersections. 1. An expandable device comprising:a plurality of strut regions extending circumferentially about the expandable device and including a plurality of struts; anda plurality of bridge regions extending between adjacent strut regions and including a plurality of bridges, the plurality of bridges including first bridges and second bridges, wherein each of the first bridges intersects one or more of the second bridges within each of the bridge regions, and wherein the first bridge is configured to move relative to the second bridge at each of the intersections.2. The expandable device of claim 1 , wherein the first bridges extend in a first rotational direction and the second bridges extend in a second rotational direction different than the first rotational direction.3. The expandable device of claim 1 , wherein each of the struts is coupled to another strut at an apex claim 1 , and wherein at least some of the apices connect to one of (a) one of the first bridges or (b) one of the second bridges.4. The expandable device of claim 1 , wherein each of the struts is coupled to another strut at an apex claim 1 , and wherein at least one of the apices connects to one of the first bridges and to one of the second bridges.5. The expandable device of claim 1 , wherein the struts may be connected end-to-end within the strut ...

Partial Circumferential Stent With Non-Radial Apposition

A medical device for sealing and repairing defects in a body lumen wall includes a wire frame and a partially-circumferential stent body. In some embodiments, the endolumenal sealing devices provided herein are well-suited for use in the GI tract including the colon. That is the case because the partially-circumferential sealing devices are configured to be compliant with the peristaltic movements of the GI tract. This feature can enable the sealing devices to resiliently remain located in a desired position within the GI tract, such that the defect in the lumen wall is sealed by the presence of the sealing device. 160-. (canceled)61. An implantable medical device for treating a portion of a body lumen wall , the device comprising:a membrane frame;a membrane material disposed on at least a portion of the membrane frame;a first strut extending from the membrane frame; anda second strut extending from the membrane frame,wherein the first and second struts are configured to press at least a portion of the membrane material into contact with the wall of the body lumen, andwherein the first and second struts each comprise an elongate member that is shaped as two arcuate segments and at least one wavy segment when the device is in a fully expanded configuration.62. The device of claim 61 , wherein the portion of the body lumen wall comprises a defect and the membrane material is configured to overlay the defect.63. The device of claim 61 , wherein the first and second struts each comprise elongate members that are unitary with an elongate member of the membrane frame.64. The device of claim 61 , wherein the first and second struts each comprise elongate members that are joined to an elongate member of the membrane frame.65. The device of claim 61 , wherein the first and second struts each comprise elongate members that are joined to an elongate member of the membrane frame by one or more of a weld claim 61 , an adhesive claim 61 , and a sleeve.66. The device of claim 61 , ...

Partial Circumferential Stent With Non-Radial Apposition

A medical device for sealing and repairing defects in a body lumen wall includes a wire frame and a partially-circumferential stent body. In some embodiments, the endolumenal sealing devices provided herein are well-suited for use in the GI tract including the colon. That is the case because the partially-circumferential sealing devices are configured to be compliant with the peristaltic movements of the GI tract. This feature can enable the sealing devices to resiliently remain located in a desired position within the GI tract, such that the defect in the lumen wall is sealed by the presence of the sealing device. 1. An implantable medical device for treating a portion of a body lumen wall , the device comprising:a membrane frame;a membrane material disposed on at least a portion of the membrane frame said membrane material having a first surface and a second surface;a pad positioned on said first surface of said membrane material;a first strut extending from the membrane frame; anda second strut extending from the membrane frame, wherein the first and second struts are configured to exert opposing non-orthogonal forces to the membrane frame to thereby press at least a portion of said first surface of the membrane material into contact with the body lumen wall.2. The device of claim 1 , wherein the portion of the body lumen wall comprises a defect and the membrane material is configured to overlay the defect.3. The device of claim 1 , wherein the first and second struts each comprise elongate members that are unitary with an elongate member of the membrane frame.4. The device of claim 1 , wherein the first and second struts each comprise elongate members that are joined to an elongate member of the membrane frame.5. The device of claim 1 , wherein the first and second struts each comprise elongate members that are joined to an elongate member of the membrane frame by one or more of a weld claim 1 , an adhesive claim 1 , and a sleeve.6. The device of claim 1 , ...

INTRAVASCULAR ANEURYSM TREATMENT DEVICE AND METHODS

An intravascular device configured to treat an aneurysm that includes a support structure including metal struts configured to be positioned in a body lumen and defining a central fluid passage that extends axially along the support structure, and a knitted mesh cover disposed over an exterior thereof and across a radial arc and along a length of the support structure sufficient to exceed an opening of an aneurysm to be treated, and the cover includes a polymer fiber having a diameter of at least 40 nanometers to 30 microns and apertures therethrough, the apertures being sized to prevent blood from passing through the device to prevent further expansion of the aneurysm. Devices including apertures that are at least 20 microns and sized to minimize or prevent an aneurysm-filling material from exiting the aneurysm through the knitted mesh cover and support structure, and methods of stenting, are also encompassed. 1. An intravascular device configured to treat an aneurysm , which comprises:a support structure comprising metal struts configured to be positioned in a body lumen and defining a central fluid passage that extends axially along the support structure; anda knitted mesh cover disposed over an exterior of the support structure, wherein the cover extends across a radial arc and along a length of the support structure sufficient to exceed an opening of an aneurysm to be treated and the cover comprises a polymer fiber having a diameter of at least 40 nanometers to 30 microns arranged to provide apertures through the cover which apertures are at least 20 microns and are sized to minimize or prevent an aneurysm-filling material from exiting the aneurysm through the knitted mesh cover and support structure into the central fluid passage.2. The intravascular device of claim 1 , wherein the aneurysm-filling material comprises one or more coils.3. The intravascular device of claim 1 , wherein a porous structure is disposed over the aneurysm-filling material to increase ...

FLOW ATTENUATION DEVICE

An embolic device for treating aneurysms or other vascular disorders may be more compliant than conventional devices, while still achieving desired porosity. In particular, the device may achieve the desired porosity only at discrete sections along the length of the device where such a porosity is required (e.g., sections that will block the neck of the aneurysm upon deployment). The remaining sections of the device can be configured to increase the device's compliance. For example, the remaining sections can be formed from less material than the sections with the desired porosity. In some instances, the sections with the desired porosity are formed from mesh-screen segments and the remaining sections are formed from coil segments. In some instances, the mesh-screen segments are configured to further enhance the device's compliance. For example, the mesh-screen segment can be formed from a layered structure that achieves greater compliance than conventional braided structures. 1. An embolic device for use in treating a vascular disorder , the embolic device comprising:a first coil segment;a second coil segment; anda mesh-screen segment,wherein the mesh-screen segment is disposed between the first coil segment and the second coil segment along a length of the embolic device.2. The embolic device of claim 1 , wherein the first and second coil segments each comprise a helically wound wire.3. The embolic device of claim 1 , wherein the first and second coil segments each comprise a greater compliance than the mesh-screen segment.4. The embolic device of claim 1 , wherein the mesh-screen segment comprises a greater porosity than each of the first and second coil segments.5. The embolic device of claim 4 , wherein claim 4 , when the mesh-screen segment is in a deployed configuration claim 4 , the mesh-screen segment is 60% to 80% porous.6. The embolic device of claim 1 , wherein the mesh-screen segment comprises two layers.7. The embolic device of claim 6 , wherein the ...

Methods, Devices, And Compositions For Treating Vascular Aneurysms

Methods, compositions, and devices for treating a vascular aneurysm, including an abdominal aortic aneurysm, are disclosed. In particular, the various embodiments relate to a method of treating an abdominal aortic aneurysm by increasing the mechanical stiffness of an aortic segment adjacent to the abdominal aortic aneurysm in a subject. The mechanical stiffness of the adjacent aortic segment may be increased, for example, by applying a surgical adhesive or intravascular stent. Such treatment reduces stress on the aortic wall and limits further growth of the abdominal aortic aneurysm. 1. (canceled)2. A method of treating a subject for a vascular aneurysm in an artery , the method comprising increasing a mechanical stiffness of at least one vascular segment adjacent to the vascular aneurysm in the subject.3. The method of claim 2 , wherein the increasing the mechanical stiffness comprises applying a surgical adhesive locally to the at least one vascular segment.4. The method of claim 2 , wherein the increasing the mechanical stiffness comprises implanting an intravascular stent that stiffens the at least one vascular segment.5. The method of claim 2 , wherein growth of the vascular aneurysm is reduced compared to in the absence of treating the subject.6. The method of claim 2 , wherein the subject shows decreased inflammation in the artery compared to in the absence of treating the subject.7. The method of claim 2 , wherein the subject shows decreased apoptosis in the artery compared to in the absence of treating the subject.8. The method of claim 2 , wherein the subject shows decreased production of reactive oxygen species in the artery compared to in the absence of treating the subject.9. The method of claim 2 , wherein the subject has an early stage vascular aneurysm.10. The method of claim 2 , wherein the at least one vascular segment comprises a vascular segment upstream of the vascular aneurysm or a vascular segment downstream of the vascular aneurysm.11. The ...

STENT DELIVERY WITH EXPANSION ASSISTING DELIVERY WIRE

A method for implanting a stent by providing an implantation system including a catheter, an expandable element, and a delivery wire, moving a first portion of the expandable element to exit the catheter, and maintaining a second portion of the expandable element within the catheter to establish a partially implanted configuration. Then moving the delivery wire independent of the expandable element in the partially implanted configuration, and enlarging a circumference of the expandable element in response to the moving the delivery wire. 1. A vascular treatment system , comprising:a sheath comprising an inner lumen;a stent collapsed within the inner lumen and comprising a distal anchor member disposed approximate a distal end of the stent and a proximal anchor disposed approximate a proximal end of the stent; anda delivery wire extending through the stent and the inner lumen and comprising a distal bump positioned between the proximal anchor and distal anchor and configured to push the distal anchor distally through the inner lumen upon distal movement of the delivery wire and a shapeable portion disposed within the stent in a proximal direction in relation to the distal bump, the shapeable portion being in a substantially straight configuration and being movable to a curved configuration upon exiting the inner lumen.2. The vascular treatment system of claim 1 ,wherein the delivery wire further comprises a central bump positioned between the proximal anchor and the distal bump and sized to engage the proximal anchor, andwherein the shapeable portion extends solely between the central bump and the distal bump.3. The vascular treatment system of claim 1 ,wherein the stent is movable to a partially implanted configuration by a distal movement of the delivery wire causing the distal bump of the delivery wire to engage with the distal anchor of the stent and push the distal anchor distally through the inner lumen, thereby expelling the distal anchor from the sheath, ...

DEVICES AND METHODS FOR TREATING AN ANEURYSM

A system and method are provided for treating an aneurysm or other vessel disease or defect. The present disclosure includes an expandable device for placement in a vessel, where the mechanically expandable device includes a membrane. Also disclosed is a delivery device constructed and arranged to position the expandable device such that the exterior surface of the expandable device engages with the inner surface of the vessel and maintains a fluid pathway through said vessel. 1. (canceled)2. A method for treating a diseased vessel in a patient , comprising:inserting a delivery device into the diseased vessel of the patient;positioning a first expandable device in the diseased vessel via the delivery device; andradially expanding the first expandable device from a first position to a second position,wherein the first expandable device comprises a membrane comprising a plurality of polymeric strips wrapped circumferentially around and secured to the first expandable device,wherein the membrane further comprises at least one porous portion comprising one or more pores, andwherein the first expandable device is positioned that such that an exterior surface of the first expandable device engages with an inner surface of the diseased vessel and maintains a fluid pathway through the diseased vessel.3. The method according to claim 2 , wherein the diseased vessel includes an intracranial aneurysm arising from a parent vessel and wherein the parent vessel comprises a diameter of approximately 2.0 mm to 5.0 mm.4. The method according to claim 2 , wherein the first expandable device is constructed and arranged to be plastically deformed when the first expandable device radially expands from the first position to the second position.5. The method according to claim 2 , wherein the first expandable device is resiliently biased in the second position.6. The method according to claim 2 , further comprising:loading the first expandable device onto the delivery device including a ...

SYSTEMS AND METHODS FOR FAILURE DETECTION OF ENDOVASCULAR STENTS

A system including a stent further including a plurality of conductive struts disposed within a non-conductive body. The stent is configured to exclude an aneurysm within a blood vessel of a person. In addition, the system includes a first electrode and a second electrode. Further, the system includes a controller coupled to the first electrode and second electrode. The controller is configured to measure an impedance between the first electrode and the second electrode and across tissue surrounding the stent to determine if a leak has occurred between the stent and the aneurysm. 1. A system , comprising:a stent including a plurality of conductive struts disposed within a non-conductive body, wherein the stent is configured to exclude an aneurysm within a blood vessel of a person;a first electrode;a second electrode; anda controller coupled to the first electrode and second electrode, the controller configured to measure an impedance between the first electrode and the second electrode and across tissue surrounding the stent to determine if a leak has occurred between the stent and the aneurysm.2. The system of claim 1 , wherein the first electrode and the second electrode are both coupled to a stent monitoring device that is configured to be inserted under the skin of the person.3. The system of claim 2 , wherein the stent monitoring device includes a communication device that is configured to wirelessly communicate with an external device disposed outside of the person.4. The system of claim 1 , wherein the first electrode and the second electrode are disposed on a catheter that is configured to be inserted within a blood vessel of the person.5. The system of claim 1 , further comprising:a signal generator coupled to the first electrode; anda measurement unit coupled to the second electrode; inject a known current into the person and one or more of the conductive struts, through the first electrode with a signal generator;', 'measure a resulting voltage at the ...

DELIVERY SYSTEM FOR DEPLOYING A SELF-EXPANDING TUBE, AND METHOD OF DEPLOYING A SELF-EXPANDING TUBE

In one arrangement, there is provided a delivery system for deploying a self-expanding tube into a blood vessel, comprising a tubular member configured for insertion into the blood vessel, an elongate body extending within a lumen of the tubular member, and a self-expanding tube positioned radially between the tubular member and the elongate body. The delivery system is configured to operate in a deployment mode in which there is relative movement longitudinally between the elongate body and a portion of the self-expanding tube that remains in engagement with the elongate body during retraction of the elongate body in use after at least a portion of the self-expanding tube has been deployed, retraction of the elongate body comprising longitudinal movement towards a proximal end of the delivery system of the elongate body relative to the tubular member. 1. A delivery system for deploying a self-expanding tube into a blood vessel , comprising:a tubular member configured for insertion into the blood vessel;an elongate body extending within a lumen of the tubular member; anda self-expanding tube positioned radially between the tubular member and the elongate body,wherein the delivery system is configured to operate in a deployment mode in which a first longitudinal engagement force acting between the self-expanding tube and the tubular member and a second longitudinal engagement force acting between the self-expanding tube and the elongate body are such that:there is substantially no relative movement longitudinally between the elongate body and any portion of the self-expanding tube that remains in engagement with the elongate body during deployment of the self-expanding tube in use, deployment of the self-expanding tube comprising longitudinal movement towards a proximal end of the delivery system of the tubular member relative to the elongate body; andthere is relative movement longitudinally between the elongate body and a portion of the self-expanding tube that ...

VASCULAR REMODELING DEVICE

Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm. 1anchoring, in the first efferent vessel, a distal section of a stent while in an expanded configuration;anchoring, in the afferent vessel, a proximal section of the stent while in the expanded configuration; andpositioning a protruding section of the stent while in the expanded configuration to abut an ostium of the aneurysm on a side of the aneurysm that is adjacent to the second efferent vessel, wherein, while in the expanded configuration, a maximum cross-sectional dimension of the protruding section is greater than a maximum cross-sectional dimension of the proximal section and a maximum cross-sectional dimension of the distal section.. A method of treating an aneurysm at a junction of a bifurcation having an afferent vessel and first and second efferent vessels, the method comprising: This application is a continuation of U.S. application Ser. No. 15/192,150, filed Jun. 24, 2016, which is a continuation of U.S. application Ser. No. 14/611,647, filed Feb. 2, 2015, now issued as U.S. Pat. No. 9,402,712 on Aug. 2, 2016, which is a continuation of U.S. application Ser. No. 13/469,214, filed May 11, 2012, now issued as U.S. Pat. No. 8,956,399 on Feb. 17, 2015, which claims priority to U.S. Provisional Patent Application No. 61/485,063, filed ...

Hybrid stent

A stent includes a high radial force segment and a highly flexible segment, where the diameters of the high radial force segment and the highly flexible segment are substantially the same. The stent may further be placed with an additional stent segment, where the additional stent segment has a radial force similar to the radial force of the highly flexible force segment.

HYBRID STENT

A stent includes a high radial force segment and a highly flexible segment, where the diameters of the high radial force segment and the highly flexible segment are substantially the same. The stent may further be placed with an additional stent segment, where the additional stent segment has a radial force similar to the radial force of the highly flexible force segment. 1. A stent , comprising:{'b': 1', '1, 'an expandable first stent segment comprising a plurality of first interconnected struts allowing the expandable first stent segment to have a first stent segment compressed state and a first stent segment expanded state, the expandable first stent segment having a first radial force RF and a first diameter D in the first stent segment expanded state; and'}{'b': 2', '2, 'an expandable second stent segment comprising a plurality of second interconnected struts allowing the expandable second stent segment to have a second stent segment compressed state and a second stent segment expanded state, the expandable second stent segment having a second radial force RF and a second diameter D in the second stent segment expanded state;'}{'b': 1', '2, 'wherein RF>RF; and'}{'b': 1', '2, 'wherein D=D.'}21212. The stent of claim 1 , wherein the expandable first stent segment in the first stent segment expanded state has a flexibility F and the expandable second stent segment in the second stent segment expanded state has a flexibility F claim 1 , wherein F Подробнее

METHODS OF PROVIDING OPTIMIZED DRUG-ELUTING STENT ASSEMBLIES

Methods of providing a stent assembly that includes a stent jacket formed from an expansible mesh structure having apertures and that includes a fiber having a diameter of about 7 micrometers and about 40 micrometers, and an expansible stent operatively associated with the stent jacket. The method further comprises administering to the subject an active pharmaceutical ingredient (API) eluted from the stent assembly. 1. A method of providing a stent assembly which comprises:providing a stent configured to be positioned in the body lumen; anddisposing a knitted stent jacket comprising an expansible mesh structure coaxially over a radial portion of the stent and along an entire length thereof, the mesh structure being formed from a single fiber and having a coverage area over the stent of about 10% to less than 20% relative to the total coverage area over the stent including a plurality of apertures therein, the apertures having approximate aperture diameters greater than 20 micrometers up to a minimum center dimension of 234 micrometers,wherein the stent assembly is configured to elute an amount of an active pharmaceutical agent that is present therein, andwherein the fiber has a diameter of approximately 7 micrometers to 40 micrometers.2. The method of claim 1 , which comprises eluting the active pharmaceutical agent from the stent.3. The method of claim 1 , which comprises eluting the active pharmaceutical agent from a coating disposed over a portion of the stent.4. The method of claim 1 , which comprises releasing the active pharmaceutical agent over time according to a predetermined treatment schedule.5. The method of claim 4 , wherein the treatment schedule is selected to cover a period of 8 hours to a plurality of months.6. The method of claim 1 , which comprises eluting the active pharmaceutical agent from the knitted stent jacket.7. The method of claim 1 , which comprises eluting the active pharmaceutical agent from a coating on the expansible mesh structure.8 ...

MONOLITHIC MEDICAL DEVICES, METHODS OF MAKING AND USING THE SAME

The monolithic device comprises a plurality of scaffolding members and a mesh patterned members webbed between the scaffolding members; the mesh patterned member webbed between the scaffolding members surround a lumen and generally expands from a contracted state to an expanded state; and mesh patterned members including a plurality of openings traversing the thickness of the mesh patterned member, and the mesh patterned members including a surface on which a pattern of openings is formed. 1. A monolithic device comprising:a stent cell pattern with a plurality of structural members configured to divert a majority of a fluid flow through the monolithic device without fully restricting the fluid flow wherein the stent cell pattern further comprises:a plurality of Z-pattern members, wherein the Z-pattern members include a plurality of peaks and a plurality of troughs along a longitudinal axis of the device, andwherein a first Z-pattern member and a second Z-pattern member positioned adjacent to the first Z-pattern member are interconnected by a plurality of interconnecting members.2. The monolithic device of claim 1 , further comprising:an end ring member including an end Z-pattern having a plurality of peaks and a plurality of troughs.3. The monolithic device of claim 1 , wherein the peaks of the end Z-pattern connect to every third trough of a Z-pattern member positioned adjacent to the end Z-pattern.4. The monolithic device of claim 1 , wherein spacing between adjacent interconnecting members is between about 0.1 and 20 microns when the monolithic device is in a deployed state.5. The device of claim 1 , wherein the monolithic device has a wall thickness between about 0.1 and about 100 microns claim 1 , and wherein the monolithic device is configured to have:a crimped state wherein the monolithic device has a diameter between about 0.2 and about 2.0 mm, andan expanded state wherein the monolithic device has a diameter between about 2.0 and about 7.0 mm.6. The ...

LUMINAL STENT

A luminal stent, including a tubular body and a skirt sleeved on the tubular body. One end of the skirt is a fixed end, and the fixed end is sealedly connected to the outer surface of the tubular body; the other end of the skirt is a free end; on a section passing through the central axis of the tubular body, the ratio of the distance between the fixed end and the free end located on the same side of the central axis of the tubular body to the vertical distance between two points of the free end on both sides of the central axis of the tubular body along the radial direction of the skirt is less than 1/2. 113-. (canceled)14. A luminal stent , comprising:a tubular body and a skirt sleeved on the tubular body, one end of the skirt is a fixed end sealedly connected with the outer surface of the tubular body, the other end of the skirt is a free end, wherein on a section passing through a central axis of the tubular body, the ratio of the distance between the fixed end and the free end located on the same side of the central axis of the tubular body to the vertical distance of the free ends on both sides of the central axis of the tubular body in the radial direction of the skirt is less than 1/2.15. The luminal stent according to claim 14 , wherein claim 14 , along the radial direction of the skirt claim 14 , the ratio of the vertical distance between the free ends on both sides of the central axis of the tubular body to the vertical distance of the fixed ends on both sides of the central axis of the tubular body is greater than or equal to 3/2.16. The luminal stent according to claim 14 , wherein the included angle between the line connecting the free end and the fixed end on the same side of the central axis of the tubular body and the central axis of the tubular body is not less than 30 degree.17. The luminal stent according to claim 14 , wherein the tubular body comprises a first radial support structure claim 14 , the skirt comprises a second radial support ...

VASCULAR STENTING FOR ANEURYSMS

Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow. 1. A braided stent , for implanting in a patient's vessel , comprising:a plurality of braided strands, having an average strand thickness, the plurality of braided strands forming pores in open areas between strands;wherein the stent is expandable from a compressed configuration to an expanded configuration;wherein the pores have an average pore length;wherein the stent has a porosity equal to a ratio of an open surface area of the stent to a total surface area of the stent;wherein, when the stent is in the expanded configuration, the porosity of the stent multiplied by the average pore length is equal to or less than about 0.3 mm.2. The stent of claim 1 , wherein each of the braided members comprises a ribbon having a width greater than its thickness.3. The stent of claim 1 , wherein each of the braided members comprises a ribbon having a width that is substantially equal to its thickness.4. The stent of claim 1 , wherein the porosity of a portion of the stent can be reduced by axially compressing the portion of the stent.5. The stent of claim 4 , wherein the axially compressed portion of the stent axially expands when unrestrained.6. The stent of claim 4 , wherein the porosity of a portion of the stent can be reduced to between ...

STENT ASSEMBLY FOR THORACOABDOMINAL BIFURCATED ANEURYSM REPAIR

A multi-lumen stent assembly () for deployment in a bifurcated vessel. This assembly is made of a self-expandable main body component () and two lumen extensions (), able to be inserted into one of the lumens of a double-barrelled portion () of the main body component (). The main body component () has a proximal end () configured to be placed toward the heart and a distal end (). The main body component () has a main body portion (), a concaved portion (), and a transition portion (). The main body portion () has a cylindrical lumen () of constant diameter. The concaved portion () has a double-barrelled portion () having two lumens (). A cross-section of the transition portion () evolving from a circular shape to an elliptical shape towards the transition portion (), a larger diameter of this shape being in a central plane (CP). 1100. A multi-lumen stent assembly () suitable for deployment in a bifurcated vessel comprising a main vessel and at least two branches , said assembly comprising:{'b': 200', '200', '201', '202, 'claim-text': [{'b': 201', '200', '203', '204, 'at the proximal end () of main body component (), a main body portion () comprising a lumen () in a cylindrical form with a circular cross-section and a constant diameter;'}, {'b': 202', '200', '206', '208', '206', '200', '210', '206', '210', '210', '210', '211', '208', '211', '211', '200, 'towards the distal end () of main body component (), a concaved portion () comprising a double-barrelled portion (), middle lines of the concaved portion () being concaved along the longitudinal axis of the main body component () and defining two opposing ridges () within an interior of the concaved portion (), each ridge () partially contacting the other ridge (), the two opposing ridges () defining two lumens () of the double-barrelled portion (), each of the two lumens () extending along an axis, the axes of the two lumens () defining a central plane (CP) which also comprises the axis of the main body component ...

COMPOSITIONS AND METHODS FOR INDUCING PHAGOCYTOSIS OF MHC CLASS I POSITIVE CELLS AND COUNTERING ANTI-CD47/SIRPA RESISTANCE

Methods and compositions are provided for inducing phagocytosis of a target cell, treating an individual having cancer, treating an individual having an intracellular pathogen infection (e.g., a chronic infection), and/or reducing the number of inflicted cells (e.g., cancer cells, cells infected with an intracellular pathogen, etc.) in an individual. Methods and compositions are also provided for predicting whether an individual is resistant (or susceptible) to treatment with an anti-CD47/SIRPA agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent (e.g., co-administration of an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent). Kits are also provided for practicing the methods of the disclosure. 1. A method of inducing phagocytosis of a target hematologic cancer cell , the method comprising:contacting a target hematologic cancer cell with a macrophage in the presence of an antibody that specifically binds to leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) and does not activate signaling through LILRB1 upon binding, and an antibody that binds to the target hematologic cancer cell and thereby opsonizes the target cell, for a period of time sufficient to induce phagocytosis of the target cell by the macrophage.2. The method of claim 1 , wherein the hematologic cancer is a leukemia.3. The method of claim 2 , wherein the leukemia is acute myeloid leukemia (AML).4. The method of claim 2 , wherein the leukemia is acute lymphoblastic leukemia (ALL).5. The method of claim 2 , wherein the leukemia is chronic myeloid leukemia (CML)6. The method of claim 2 , wherein the leukemia is chronic lymphocytic leukemia (CLL).7. The method of claim 1 , wherein the hematologic cancer is a lymphoma.8. The method of claim 7 , wherein the lymphoma is Hodgkin lymphoma.9. The method of claim 7 , ...

FLEXIBLE VASCULAR OCCLUDING DEVICE

A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain. The neurovascular occluding device can be deployed using a micro-catheter. The occluding device can be formed by braiding wires in a helical fashion and can have varying lattice densities along the length of the occluding device. The occluding device could also have different lattice densities for surfaces on the same radial plane. 120-. (canceled)21. A device for positioning within a blood vessel for treatment of an aneurysm , the device comprising:a plurality of braided members, wherein the braided members form a lattice structure along the length of the device, each of the braided members comprising an inner surface and an outer surface, the outer surface being configured for positioning adjacent an inner wall of a vessel, and the outer surface forming a portion of an outer circumference of the device between first and second ends of the device, the plurality of braided members forming a plurality of openings extending between adjacent members of the device, the outer surfaces of the plurality of braided members comprising between about 20 percent to about 50 percent of a total circumferential area of the device,wherein the device in configured to freely bend 90 degrees about a fulcrum upon application of a bending moment of 0.005 lb-in to the device, and to be compressed to 50% of an original diameter of the device upon application of a force of less than 10 grams, when the device is fully deployed from a delivery catheter.22. The device of claim 21 , wherein the openings occupy between about 50 to about 80 percent of the total circumferential area of the device.23. The device of claim 21 , comprising a length that can be adjusted during deployment such that the deployed length of the ...

IMPLANTABLE FLOW ADJUSTER

An implantable flow adjuster () includes proximal and distal support rings () which support a flow adjuster panel (). The flow adjuster panel () divides the lumen through the device () into two sections, one of reducing cross sectional area and the other of increasing of increasing cross sectional area. The two sections () cause, respectively, an increase in blood pressure and blood flow and a decrease in blood pressure and blood flow. These result is a pressure differential beyond the distal end of the device (). This pressure differential can be used to divert blood flow away from the neck () into an aneurysm (), thus to reduce pressure and wall sheer stress within the aneurysm in order to assist in the repair of the vessel. 1. An endoluminal flow adjuster comprising:an elongate support structure having a tubular shape and a diameter and a proximal end and a distal end, and defining a longitudinal passage for the flow of fluid through the support structure between the proximal end and the distal end, wherein the proximal end and the distal end are open;a panel having a length and a surface extending between the proximal and distal ends of the support structure and held and supported by the support structure, the panel dividing the passage through the flow adjuster into first and second parts varying in size over at least a part of the length of the flow adjuster, wherein the passage defines an overall cross-sectional size perpendicular to the longitudinal direction, and the cross-sectional size of the first and second parts of the passage combine to define the overall cross-sectional size of the passage, and a ratio between the cross-sectional size of the first part and the cross-sectional size of the second part varies over at least a part of the length of the flow adjuster, wherein the first part of the passage is open at both the proximal and distal ends and the second part of the passage is open at both the proximal and distal ends such that fluid flow is ...

VASCULAR REMODELING DEVICE

A generally spherical vascular remodeling device is permanently positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device at the junction to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and the device permits perfusion to the efferent vessels. Positioning the device may include deployment and mechanical or electrolytic release from a catheter. Embolic material may be inserted in the aneurysm before or after positioning the device. The device may have a first end, a second end substantially opposite to the first end, and a plurality of filaments extending between and coupled at the first end and the second end. Such devices may be football shaped, pumpkin shaped, or twisted. The device may include a plurality of loops forming a generally spherical shape. 126-. (canceled)27. A vascular remodeling device comprising:a plurality of filaments, each filament extending between a proximal end and a distal end to form a generally spherical shape having an outer periphery;a plurality of proximal struts integral with the filaments and connecting adjacent pairs of the filaments at the proximal ends of the filaments and at a proximal location outside the outer periphery of the generally spherical shape;a plurality of distal struts integral with the filaments and interconnecting adjacent pairs of the filaments at the distal ends of the filaments and at a distal location substantially opposite to the proximal location along a longitudinal axis of the device and outside the outer periphery of the generally spherical shape;a proximal sleeve positioned around the proximal ends of the filaments; anda distal sleeve positioned around the distal ends of the filaments.28. The vascular remodeling device of claim 27 , wherein each adjacent pair of the filaments are connected by a pair of distal struts at the distal ends.29 ...

ENDOLUMINAL DEVICE AND METHOD

An endoluminal device can be configured for precise positioning during deployment within a vessel. The endoluminal device can be a tack, stent, vascular implant or other type of implant. The endoluminal device can have circumferential member with an undulating configuration having multiple inward and outward apexes and struts extending therebetween. Two of the struts can be used to establish a foot for the precise positioning of the device during deployment. A method of placing the endoluminal device can include withdrawing an outer sheath such that a portion of the endoluminal device is expanded prior to the rest of the endoluminal device. 119.-. (canceled)20. A self-expanding intravascular implant comprising: a plurality of proximal ring struts, each proximal ring strut of the plurality of proximal ring struts having a proximal end and a distal end;', 'a plurality of proximal ring proximal apices, wherein each proximal ring proximal apex of the plurality of proximal ring proximal apices connects two proximal ends of two proximal ring struts of the plurality of proximal ring struts; and', 'a plurality of proximal ring distal apices, wherein each proximal ring distal apex of the plurality of proximal distal apices connects two distal ends of two proximal ring struts of the plurality of proximal ring struts;, 'a proximal sinusoidal ring forming a proximal end of the self-expanding intravascular implant, the proximal sinusoidal ring comprising a plurality of distal ring struts, each distal ring strut of the plurality of distal ring struts having a proximal end and a distal end;', 'a plurality of distal ring distal apices, wherein each distal ring distal apex of the plurality of distal ring distal apices connects two distal ends of two distal ring struts of the plurality of distal ring struts; and', 'a plurality of proximal ring distal apices, wherein each distal ring proximal apex of the plurality of proximal ring distal apices connects two proximal ends of two distal ...

Medical device and system having such a device

A medical device, having a body that is tubular at least in some sections. The body can be transferred from a compressed state into an expanded state and has a circumferential wall having at least one first lattice structure and one second lattice structure. The first lattice structure and the second lattice structure form separate layers of the circumferential wall, which are arranged coaxially one inside the other and connected to each other at least at points in such a way that the first lattice structure and the second lattice structure can be moved relative to each other at least in some sections. A system having such a device is also disclosed.

Stent Delivery System And Method

A stent, a stent delivery system, and a method of delivering a stent are described that allow the porosity of the stent to be changed dynamically during a delivery procedure. Unlike prior stents and procedures that are configured to deploy with a predetermined porosity, the physician can create a region of high stent porosity over certain vessel features, a low stent porosity over other vessel features, and can create these porosity changes with at least one stent or stent layer.

ANTI-THROMBOGENIC MEDICAL DEVICES

Medical devices that include a tubular member with a plurality of braided filaments, each filament crossing another of the filaments at a respective crossing point forming sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores have an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device with pores substantially free of webs formed by antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by antithrombogenic material thereby permitting the pores to be substantially free of webs. 135.-. (canceled)36. A medical device for treating an aneurysm , comprising:a tubular member comprising a plurality of braided filaments that form a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores having an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, and each of the filaments crossing another of the filaments at a respective crossing point,the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device wherein the pores are substantially free of webs formed by an antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by the antithrombogenic material thereby permitting the pores to be substantially free of webs.37. The medical device of claim 36 , wherein the pores ...

PROCEDURES FOR VASCULAR OCCLUSION

A method of reducing blood flow within an aneurysm includes: injecting a contrast agent into a blood vessel including an aneurysm; expanding a stent, from a delivery device, across the aneurysm; and confirming that a stagnated area forms in the aneurysm. The stagnated area can form a crescent shape, a mushroom shape, a hemispherical shape, and/or a flat side. Upon confirming that the stagnated area forms in the aneurysm, the delivery device can be withdrawn from the blood vessel. The stagnated area can include the contrast agent. If the stagnated area does not form in the aneurysm, a second occluding device may be deployed. After withdrawing the delivery device, substantially all of the aneurysm progressively thromboses. 1. (canceled)2. A method of reducing blood flow within an aneurysm comprising:injecting a contrast agent into a blood vessel comprising an aneurysm, at least a portion of the contrast agent flowing into the aneurysm;deploying an occlusion device from a delivery device in the blood vessel at the aneurysm;stagnating the portion of the contrast agent in the aneurysm;producing an image of the aneurysm including the portion of the contrast agent;observing a shape formed by the portion of the contrast agent in the aneurysm after deploying the occlusion device; andwithdrawing the delivery device from the blood vessel after observing the shape.3. The method of claim 2 , wherein the shape comprises a crescent shape claim 2 , a mushroom shape claim 2 , a hemispherical shape claim 2 , and/or a flat side.4. The method of claim 2 , wherein the shape formed by the contrast agent comprises a stagnated area in the aneurysm.5. The method of claim 2 , wherein after withdrawing the delivery device claim 2 , substantially all of the aneurysm progressively thromboses.6. The method of claim 2 , wherein the confirming is sufficient to determine that the deploying the occlusion device is sufficient to lead to thrombosis of the aneurysm.7. The method of claim 2 , wherein ...

COUPLING UNITS FOR MEDICAL DEVICE DELIVERY SYSTEMS

A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. The coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member. 1. (canceled)2. A stent delivery system , comprising:a core member having a distal segment; a proximal restraint coupled to the core member distal segment;', 'a distal restraint coupled to the core member distal segment at a position distal to the proximal restraint; and', a proximal end surface;', 'a distal end surface;', 'a radially outer side surface extending longitudinally between the proximal and distal end surfaces, the outer side surface including a plurality of projections separated by recesses; and', 'a radially inner side surface extending between the proximal and distal end surfaces, the inner side surface defining a hole through which the core member extends, the hole having a radial dimension that is larger than a radially outer dimension of the core member distal segment such that the plate can slide and rotate with respect to the core member,', 'wherein the plate has a thickness defined by a distance between the proximal end surface and the distal end surface, and a largest radial dimension defined by a maximum length of the proximal and distal end surfaces, wherein the largest radial dimension is at least 5 times greater than the thickness; and, 'a rigid plate slidably and rotatably coupled to the core member distal segment between the proximal restraint and the distal ...

Stent delivery system, corresponding flow diversion device, and assembly method of flow diversion device

A stent delivery system provided by the present application comprises: a radiopaque tip located at the distal end of the stent delivery system; a beads component comprising at least one expandable part; a funnel component comprising a distal flare structure and a proximal collapsed end, wherein the cross-section of the flare structure gradually increases from its minimum diameter to its maximum diameter along the proximal-to-distal direction; and a core wire located at the proximal end of the stent delivery system; and wherein the distal end of the beads component is fixed on the radiopaque tip and the proximal end of the beads component is fixed on the core wire; wherein the funnel component is coupled with the beads component and the core wire, and is fixed on the core wire through the collapsed end. The present application also provides a flow diversion device and an assembly method of the flow diversion device.

MEDICAL DEVICE FOR TREATING ANEURYSMS

The invention relates to a medical device for treating aneurysms, in particular a stent, including a compressible and expandable grid structure made up of grid elements. The grid structure has at least one closed cell ring which includes at most 12, in particular at most 10, in particular at most 8, in particular at most 6 cells directly adjacent to one another in a circumferential direction of the grid structure. The grid structure is provided at least in certain portions with a covering made of an electrospun fabric which has pores of irregular sizes. The covering includes over a surface area of 100 000 μm2 at least 10 pores which have a size of at least 15 μm2. The covering has a biocompatible, in particular antithrombogenic and/or endothelialization-promoting coating. 118-. (canceled)19. A medical device for treatment of an aneurysm comprising:a compressible and expandable mesh structure having at least one closed cell ring which includes at most 12 immediately adjacent cells in a circumferential direction of the mesh structure,{'sup': 2', '2, 'wherein the mesh structure is provided, at least in sections, with a covering produced from an electrospun fabric having irregularly sized pores, wherein the covering includes at least 10 pores with a size of at least 15 μmover an area of 100000 μm, and wherein the covering has a biocompatible coating.'}20. The medical device according to wherein at least part of the coating includes fibrin.21. The medical device according to wherein the coating has a layer thickness of at least 10 nm.22. The medical device according to wherein one of the covering is cohesively connected to the mesh structure or the coating is cohesively connected to the covering.23. The medical device according to wherein the coating is bonded to a surface of the covering.24. The medical device according to wherein the coating has a thickness between 5 nm and 100 nm.25. The medical device according to wherein the mesh structure includes mesh elements ...

Aneurysm devices with additional anchoring mechanisms and associated systems and methods

The present technology relates to aneurysm devices with additional anchoring mechanisms, and associated systems and methods. The aneurysm device is endovascularly deliverable to a site proximate an aneurysm near a parent artery with bifurcating branches. The device can include a closure structure comprising a distal-facing aspect configured to at least partially occlude the aneurysm. The closure structure can be formed from a generally flat pattern and is transformable between a compressed configuration and a deployed configuration. The device can also have one or more lodging elements which fold to form loop elements configured for anchoring within at least one of the bifurcating branches. The struts of the lodging elements can include hinge points which bias the folding of the lodging elements. The devices further include a supplemental stabilizer connected to the closure structure and configured to reside in the parent artery.

Medical set for treating aneurysms, production process, and medical system for treating aneurysms

The invention relates to a medical set for treating aneurysms, including a main catheter and a covering device which can be moved through the main catheter to a treatment site and is intended to cover an aneurysm. The covering device is connected or can be connected to a transporting wire and includes a self-expandable grid structure made up of webs that are connected to one another in one piece and delimit inner cells and outer cells. The outer cells form at one longitudinal end of the grid structure a closed outer-cell ring, which is connected only on one side to inner cells. The grid structure is provided with a covering made of a fabric which has pores of irregular sizes, wherein at least one inner cell of the grid structure is at least partially, in particular mostly, free from the covering. A production process and a medical system are also provided.

Methods of treating a thrombus in a vein using cyclical aspiration patterns

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

MESHES, DEVICES AND METHODS FOR TREATING VASCULAR DEFECTS

Devices that can be delivered into a vascular system to divert flow are disclose herein. According to some embodiments, devices are provided for treating aneurysms by diverting flow. An expandable device can comprise, for example, first a plurality of strut regions and a plurality of bridge regions. Each of the bridge regions may connect a first strut of a first strut region to a second strut of a second strut region. The first strut region may comprise a first plurality of apices defining a first circumferential plane, and the second strut region may comprise a second plurality of apices defining a second circumferential plane. A first curved segment of the bridge may extend across the first circumferential plane towards the first strut region, and a second curved segment of the bridge may extend across the second circumferential plane towards the second strut region. 1. An expandable device comprising:a plurality of strut regions extending circumferentially about the expandable device, each of the strut regions including a plurality of struts and a plurality of apices; anda plurality of bridge regions extending between adjacent strut regions and including a plurality of bridges, wherein each of the bridges includes a first curved segment and a second curved segment having opposing concavities;wherein each of the bridges connects a first strut of a first strut region to a second strut of a second strut region adjacent to the first strut region, the first strut region comprising a first plurality of apices extending towards the second strut region and defining a first circumferential plane, the second strut region comprising a second plurality of apices extending towards the first strut region and defining a second circumferential plane, with the first curved segment of the bridge extending across the first circumferential plane towards the first strut region, and the second curved segment of the bridge extending across the second circumferential plane towards the ...

Medical devices including metallic films and methods for making same

Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a metallic film comprising nickel, titanium, and chromium, wherein a ratio of a weight of chromium of the metallic film to a combined weight of nickel, titanium, and chromium of the metallic film is at least 0.001. The metallic film can include a shape memory alloy.

SELF-EXPANDABLE STENT

A self-expandable stent includes a plurality of first wires and a plurality of second wires interwoven together. A first anchor member is attached to a distal end of one of the plurality of first wires. The distal end of the first anchor member is fixed to the distal end of the one of the plurality of first wires, but the proximal end is a free end and is not fixed to any of the plurality of first wires or to any of the plurality of second wires. Consequently, the self-expandable stent is capable of contacting a blood vessel wall or digestive organ wall at the optimal position when the self-expandable stent is expanded at the target site. A gap is not easily formed between the anchor member and the blood vessel wall or digestive organ wall, and thus the self-expandable stent is not easily dislocated from the target site. 1. A self-expandable stent comprising:a plurality of first wires;a plurality of second wires interwoven with the plurality of first wires; anda first anchor member attached to a distal end of one of the plurality of first wires,wherein a distal end of the first anchor member is fixed to a distal end of the one of the plurality of first wires, and a proximal end of the first anchor member is not fixed to any of the plurality of first wires or to any of the plurality of second wires.2. The self-expandable stent according to claim 1 , further comprising:a second anchor member attached to a distal end of one of the plurality of first wires that is different from the one of the plurality of first wires to which the first anchor member is attached, wherein:a distal end of the second anchor member is fixed to the one of the plurality of first wires that is different from the one of the plurality of first wires to which the first anchor member is attached, and a proximal end of the second anchor member is not fixed to any of the plurality of first wires or to any of the plurality of second wires, andthe second anchor member is disposed at a position ...

ENDOLUMINAL DEVICE HAVING BARB ASSEMBLY AND METHOD OF USING SAME

An endoluminal device for implantation in a body lumen reduces movement or migration of the device after implantation by the use of barbs or barb assemblies. A first embodiment uses at least one barb assembly having first and second portions attached to an implant, such as a stent, and at either sides of a bend. The second portion is adapted to protrude radially inward when the implant is in the radially compressed configuration and radially outward when the implant is in its radially expanded configuration. A second embodiment uses a barb having a curved segment which is curved proximally and radially inwardly. A third embodiment utilizes at least one barb assembly having a wire with a length greater than the cell height of the implant across which it extends and a substantially uniform cross-sectional area. Methods for implanting such devices are also contemplated. 1. A device for implantation in a body lumen comprising:an implant having a radially compressed configuration and a radially expanded configuration and comprising at least one filament which pivots as said implant moves between said radially compressed configuration and said radially expanded configuration; andat least one barb assembly comprising a first portion attached to said implant, a bend, and a second portion, disposed opposite said first portion from said bend and having a bearing surface, wherein said second portion is adapted to protrude radially inward when said implant is in said radially compressed configuration and said at least one filament radially contacts and imparts a radially outward force against said bearing surface as said implant moves from said radially compressed configuration to said radially expanded configuration to cause said second portion to protrude radially outward when said implant is in said radially expanded configuration.2. A device as defined in claim 1 , wherein said barb assembly comprises a first wire and a second wire; a first end of said first wire and a ...

FLEXIBLE DEVICES

A self expanding flexible or balloon expandable flexible device includes a helical strut member helically wound about an axis of the stent. The helical strut member comprises a plurality of helical strut elements. A plurality of individual helical elements are helically wound about the axis of the device in the same direction of the helical strut member with the helical elements extending between and interconnecting points on subsequent windings of the helical strut member. The device can be a flow diverter, anchor, revascularization device or filter. A self expanding flexible bifurcation device can include at least one leg. The at least one leg comprising the helical strut member and the plurality of individual helical elements helically wound about the axis of the device in the same direction of the helical strut member with the helical elements extending between and interconnecting points on subsequent windings of the helical strut member. 1. (canceled)2. A balloon expandable flexible device comprising:a helical strut member helically wound about an axis of said stent, said helical strut member comprising a plurality of helical strut elements; anda plurality of individual helical elements helically wound about said axis of said device in the same direction of said helical strut member with said helical elements extending between and interconnecting points on subsequent windings of said helical strut member;wherein said device is a flow diverter.3. (canceled)4. A balloon expandable flexible bifurcation device comprising at least one leg , said at least one leg comprising:a helical strut member helically wound about an axis of said stent, said helical strut member comprising a plurality of helical strut elements; anda plurality of individual helical elements helically wound about said axis of said device in the same direction of said helical strut member with said helical elements extending between and interconnecting points on subsequent windings of said helical ...

ENDOPROSTHESIS ASSEMBLIES AND METHODS TO USE THE SAME

Endoprosthesis assemblies and methods for using the same. In at least one embodiment, the endoprosthesis assembly comprises an endoprosthesis comprising an impermeable inner wall defining an endoprosthesis lumen sized and shaped to permit fluid to flow therethrough, a distal balloon positioned at or near a distal end of the endoprosthesis and capable of inflation to anchor the distal end of the endoprosthesis within a luminal organ, and a proximal balloon positioned at or near a proximal end of the endoprosthesis and capable of inflation to anchor the proximal end of the endoprosthesis within the luminal organ, wherein when the endoprosthesis assembly is positioned within the luminal organ at or near an aneurysm sac, inflation of the distal balloon and the proximal balloon effectively isolates the aneurysm sac and prevents fluid within the aneurysm sac from flowing past the distal balloon and the proximal balloon. 1. An endoprosthesis assembly , comprising:an endoprosthesis having an impermeable inner wall;a first balloon at or near a distal end of the endoprosthesis and a second balloon at or near the proximal end of the prosthesis; anda first tube defining one or more tube openings positioned on a relative outside of the inner wall;wherein the endoprosthesis assembly is configured to isolate an aneurysm sac of a luminal organ when positioned therein.2. The endoprosthesis assembly of claim 1 , wherein the endoprosthesis further comprises a permeable outer wall adjacent to the impermeable inner wall.3. The endoprosthesis assembly of claim 2 , wherein the permeable outer wall is configured so that fluid can flow through the permeable outer wall due to its permeability.4. The endoprosthesis assembly of claim 2 , wherein the first tube is positioned within the permeable outer wall.5. The endoprosthesis assembly of claim 2 , further comprising:a second tube defining one or more second tube openings positioned at or within the outer wall of the endoprosthesis.6. The ...

Stent with Outer Member to Embolize an Aneurysm

This invention is a stent to reduce blood flow to an aneurysm comprising: (a) an inner member, wherein this inner member is expanded from a first configuration to a second configuration within the parent vessel of an aneurysm, wherein the circumference of the second configuration is larger than the circumference of the first configuration; and (b) an outer member, wherein this outer member is less porous than the inner member, wherein this outer member covers or surrounds a first percentage of the surface area of the inner member when the inner structure is in the first configuration, wherein this outer member covers or surrounds a second percentage of the surface area of the inner member when the inner structure is in the second configuration, and wherein the second percentage less than the first percentage.

INTRALUMINAL VASCULAR PROSTHESIS

The present invention relates to an intraluminal vascular prosthesis for implantation into a blood vessel, with a stent framework and a prosthesis material secured onto the stent framework, wherein the vascular prosthesis has a hollow-cylindrical body with a lumen passing there through and a circumferentially closed jacket, wherein at least one substantially U-shaped or V-shaped fenestration-cut in the prosthesis material of the vascular prosthesis is provided, which is dimensioned and formed, such, that via the fenestration-cut a flap-like access to the lumen of the vascular prosthesis for at least one side branch branching off from the hollow-cylindrical body can be formed. 1. An intraluminal vascular prosthesis for implantation into a blood vessel , with a stent framework and a prosthesis material secured onto the stent framework , wherein the vascular prosthesis has a hollow-cylindrical body with a lumen passing there through and a circumferentially closed jacket , whereinat least one substantially U-shaped or V-shaped fenestration-cut in the prosthesis material of the vascular prosthesis is provided, which is dimensioned and formed, such, that via the fenestration-cut a flap-like access to the lumen of the vascular prosthesis for at least one side branch branching off from the hollow-cylindrical body can be formed.2. The intraluminal vascular prosthesis according to claim 1 , wherein the intraluminal vascular prosthesis has between one and nine fenestration-cuts on at least one circumferential portion U.3. The intraluminal vascular prosthesis according to claim 1 , wherein the stent framework of the intraluminal vascular prosthesis is made of rings of meandering circumferential struts arranged one behind the other in its longitudinal direction claim 1 , but not connected to one another.4. The intraluminal vascular prosthesis according to claim 1 , wherein the stent framework extends over the entire length of the vascular prosthesis.5. The intraluminal vascular ...

Delivery System For A Prosthesis

A method of making a delivery system for a prosthesis includes providing a catheter shaft, sliding a plurality of rings over the catheter shaft, each of the rings having an inner diameter larger than an outer diameter of the catheter shaft, fixing a pull wire to each of the plurality of rings at a common circumferential location of the catheter shaft, and coupling a sheath to the pull wire, the sheath positioned over the prosthesis at a distal end of the catheter shaft. Fixing the pull wire to each of the plurality of rings can include wrapping a heat shrink film around each of the plurality of rings and the pull wire, and heating the heat shrink material. 1. A method of making a delivery system for a prosthesis , comprising:providing a catheter shaft;sliding a plurality of rings over the catheter shaft, each of the rings having an inner diameter larger than an outer diameter of the catheter shaft;fixing a pull wire to each of the plurality of rings at a common circumferential location of the catheter shaft; andcoupling a sheath to the pull wire, the sheath positioned over the prosthesis at a distal end of the catheter shaft.2. The method of making according to claim 1 , wherein the plurality of rings comprises a first ring claim 1 , a second ring claim 1 , and a third ring spaced apart along the catheter shaft proximal of a proximal end of the sheath.3. The method of making according to claim 1 , wherein fixing the pull wire comprises wrapping a heat shrink film around each of the plurality of rings and the pull wire claim 1 , and heating the heat shrink material.4. The method of making according to claim 3 , wherein wrapping the heat shrink film creates a first frictional force on the pull wire with respect to the plurality of rings claim 3 , the first frictional force being less than a predetermined design maximum to permit movement of the pull wire with respect to the plurality of rings.5. The method of making according to claim 4 , wherein the first frictional ...

PROCEDURES FOR VASCULAR OCCLUSION

A method of reducing blood flow within an aneurysm includes: injecting a contrast agent into a blood vessel including an aneurysm; expanding a stent, from a delivery device, across the aneurysm; and confirming that a stagnated area forms in the aneurysm. The stagnated area can form a crescent shape, a mushroom shape, a hemispherical shape, and/or a flat side. Upon confirming that the stagnated area forms in the aneurysm, the delivery device can be withdrawn from the blood vessel. The stagnated area can include the contrast agent. If the stagnated area does not form in the aneurysm, a second occluding device may be deployed. After withdrawing the delivery device, substantially all of the aneurysm progressively thromboses 1. A method of reducing blood flow within an aneurysm comprising:injecting a contrast agent into a blood vessel comprising an aneurysm;deploying an occlusion device from a delivery device in the vessel next to the aneurysm;producing an image of the aneurysm including the contrast agent;confirming that the contrast agent forms a shape after deploying the occlusion device; andwhile the contrast agent has formed the shape, withdrawing the delivery device from the vessel.2. The method of claim 1 , wherein the shape comprises a crescent shape claim 1 , a mushroom shape claim 1 , a hemispherical shape claim 1 , and/or a flat side.3. The method of claim 1 , wherein the shape formed by the contrast agent comprises a stagnated area in the aneurysm.4. The method of claim 1 , wherein after withdrawing the delivery device claim 1 , substantially all of the aneurysm progressively thromboses.5. The method of claim 1 , wherein the confirming is sufficient to determine that the deploying the occlusion device is sufficient to lead to thrombosis of the aneurysm.6. The method of claim 1 , wherein the confirming comprises comparing a first image of the aneurysm before deploying the occlusion device to a second image of the aneurysm after deploying the occlusion device.7 ...

RELEASABLE VASCULAR DEVICE CONNECTION

A medical device, for insertion into an anatomical vessel, can include a sheath, a delivery wire, and a frame or vessel-engaging member. The delivery wire can have a first stop, a second stop, and a coupling area between the first and second stops. The coupling area can be disposed within and movable relative to the sheath. The frame or vessel-engaging member can have a matrix of cells, first and second tapered sections, and interlocking members. The interlocking members can be attached to the tapered sections. The interlocking members can be releasably coupled to the delivery wire at the coupling area with the interlocking members surrounded and held in the coupling area by the sheath. The interlocking members can be movable relative to the sheath, and the interlocking members can separate from each other when the interlocking members are positioned distal to the sheath. 1. A medical device , comprising:a sheath;a delivery wire having a first stop, a second stop, and a coupling area between the first and second stops, the coupling area disposed within and movable relative to the sheath; anda vessel-engaging member comprising a matrix of cells, first and second tapered sections, and interlocking members, the first and second tapered sections tapering in a proximal direction, the interlocking members attached to the tapered sections, the interlocking members releasably coupled to the delivery wire at the coupling area with the interlocking members surrounded and held in the coupling area by the sheath, the interlocking members movable relative to the sheath, each of the interlocking members comprising a tab having fingers extending therefrom, the fingers of the tabs interlocking with each other at the coupling area, the interlocking members being biased apart such that the interlocking members release from the delivery wire upon moving the sheath, the vessel-engaging member, or both such that the interlocking members are distal to the sheath.2. The medical device of ...

Methods of treating a vessel using an aspiration pattern

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

Hybrid stent

A stent includes a high radial/crush force segment and a highly flexible segment. In an aspect, a plurality of first ring struts connected such that each of the plurality of first rings comprises a sinusoidal pattern having a plurality of apices and troughs, each first ring connected to an adjacent first ring by at least one connector. The connector extends from a ring strut of the first ring from a position near an apex of the first ring to a ring strut of the adjacent first rings near an apex of the adjacent ring, and a second stent segment comprises a plurality of second rings connected to one another to form a series of second rings

SYSTEMS AND METHODS FOR DELIVERY RETRIEVABLE STENTS

Systems and method for delivering and deploying an expandable stent to treat Intracranial atherosclerotic disease (ICAD) involving large and medium-sized blood vessels. The disclosed systems include a catheter, a shaft comprising a distal end disposed within the catheter, an expandable stent comprising a proximal end and a distal end, wherein the shaft is coupled to the expandable stent and the shaft is disposed within the expandable stent, and a plurality of struts, wherein a first end of each strut is coupled to the shaft and a second end of each strut is coupled to the expandable stent. Longitudinal movement of the shaft relative to the expandable stent extends the plurality of struts radially outward and expands the expandable stent, similar to umbrella. The plurality of struts provides radial force to the expandable stent in an expanded configuration to the vessel walls of the patient. 1. A stent delivery system for delivery and deploying an expandable stent comprising:a catheter;a shaft comprising a distal end, disposed within the catheter; andan expandable stent comprising a proximal end and a distal end, wherein the shaft is coupled to the expandable stent and the shaft is disposed within the expandable stent,wherein the expandable stent comprises a plurality of filaments, wherein the filaments form a braiding pattern, andwherein longitudinal movement of the shaft relative to the expandable stent pulls the distal end of the expandable stent proximal end of the expandable stent toward one another and expands the expandable stent.2. The stent delivery system of claim 1 , wherein the distal end of the shaft is coupled to the distal end of the expandable stent.3. The stent delivery system of claim 1 , wherein a proximally oriented force applied to the shaft expands the expandable stent.4. The stent delivery system of claim 1 , wherein the plurality of filaments form a half-load braiding pattern.5. The stent delivery system of claim 1 , wherein the plurality of ...

ENDOVASCULAR PROSTHESIS AND DELIVERY DEVICE

In one of its aspects, the present invention relates to an endovascular prosthesis. The endovascular prosthesis includes a first expandable portion expandable from a first, unexpanded state to a second, expanded state to urge the first expandable portion against a vascular lumen and a retractable leaf portion attached to the first expandable portion. The retractable leaf portion comprises at least one spine portion and a plurality of rib portions attached to the spine portion. Longitudinally adjacent pairs of rib portions are free of interconnecting struts. The endovascular prosthesis that can be unsheathed and re-sheathed for repositioning of the endovascular prosthesis prior to final deployment thereof. There is also described a delivery device that that is particularly well suited to delivering the present endovascular prosthesis through tortuous vasculature in the body. 1. A self-expanding endovascular prosthesis comprising:a first expandable portion expandable from a first, unexpended state to a second, expanded state to urge the first expandable portion against a vascular lumen; anda retractable leaf portion attached to the first expandable portion, the retractable leaf portion comprising a single spine portion connected to the first expandable portion and a plurality of rib portions attached to the spine portion, the single spine portion comprising a pair of rows of rib portions, each row of rib portions connected to one side of the single spine portion, longitudinally adjacent pairs of rib portions being free of interconnecting struts;wherein, in an expanded configuration of the self-expanding prosthesis, the single spine portion comprises a first radius of curvature over the length of the single spine about an axis transverse to a longitudinal axis of the endovascular prosthesis.2. The endovascular prosthesis defined in claim 1 , wherein claim 1 , in two dimensions claim 1 , each rib portion comprises a rib proximal portion claim 1 , a rib distal portion ...

Hollow tubular drug eluting medical devices

A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.

Thin film vascular stent and biocompatible surface treatment

A vascular implant, comprising a sheet comprising thin film nickel titanium (NiTi), wherein the sheet has at least one super-hydrophilic surface having a water contact angle of less than approximately 5 degrees. The sheet is configured to have a compacted form having a first internal diameter and a deployed form having a second internal diameter larger than the first internal diameter. The sheet may be delivered into a blood vessel in the compacted form and expanded to its deployed form at a treatment location within the blood vessel, wherein the stent is configured to expand onto an internal surface of the blood vessel and exert a radial force on said internal surface.

PHOTON-ACTIVATABLE GEL COATED INTRACRANIAL STENT AND EMBOLIC COIL

An intracranial stent includes a proximal end, a distal end, and a tubular sidewall extending there between and a patch covering at least a portion of the sidewall; wherein the patch is capable of diverting blood flow past the neck of an intracranial aneurysm. The patch may be made of a photon-activatable material or a tightly woven metal material with a density greater than a density of the sidewall itself. 1. A method of treating a cerebral aneurysm of a patient comprising the steps of:providing a stent delivery system, wherein the stent delivery system comprises a microcatheter comprising a proximal end portion and a distal end portion, wherein the distal end portion is covered by a radiation-shielding element;positioning the delivery system within a cerebral vessel so that the distal end of the catheter is disposed at a neck of the aneurysm; a proximal end;', 'a distal end;', 'a tubular sidewall extending between the proximal end and the distal end; and', 'a photon-activatable patch covering at least a portion of the sidewall; and, 'deploying an intracranial stent, wherein the intracranial stent comprisesactivating the photon-activatable gel on the stent using a photon source, wherein when the photon-activatable gel is activated the gel expands and covers the aneurysm orifice to seal the aneurysm off from a parent circulation.2. The method of claim 1 , wherein activating the photon-activatable gel comprises activating the photon-activatable gel using x-ray photons external to the patient's body.3. The method of claim 1 , wherein activating the photon-activatable gel comprises activating the photon-activatable gel using light emitting diodes (LED).4. The method of claim 1 , wherein activating the photon-activable gel comprises activating the photon-activatable gel using a light source comprising quartz.5. The method of claim 1 , wherein activating the photon-activable gel comprises activating the photon-activatable gel using a light source comprising tungsten- ...

THIN-FILM MICROMESH AND RELATED METHODS

Thin-film mesh for medical devices and related methods are provided. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh may be used as a cover for a stent device. The thin-film mesh has a tube-shape and the slits may be angled with respect to a longitudinal axis of the tube-shape thin-film mesh. The angled slits allow for the thin-film mesh to expand in multiple dimensions, including along the longitudinal axis and along the circumferential direction of the tube-shape thin-film mesh. The slits may be provided in diagonal rows arranged in longitudinal columns. Longitudinal columns of different types of slits may be arranged along the circumferential direction on the tube-shape thin-film mesh to form a zig-zag pattern of slits. The thin-film mesh may be formed from thin-film Nitinol (TFN) and may be fabricated via sputter deposition on a micropatterned wafer. 1. A thin-film micromesh device comprising:a backbone extending in a longitudinal axis; anda thin-film micromesh assembled on the backbone, the thin-film micromesh comprising one of more slits elongated in a slit axis, wherein the slit axis is angled from the longitudinal axis.2. The thin-film micromesh device of claim 1 , wherein the one or more slits are expandable in an expansion axis perpendicular to the slit axis.3. The thin-film micromesh device of claim 1 ,wherein the thin-film micromesh device has a cylindrical shape, andwherein the one or more slits are expanded such that the thin-film micromesh is expandable both along the longitudinal axis of the cylindrical shape thin-film micromesh and along a circumferential direction of the cylindrical shape thin-film micromesh.4. The thin-film micromesh device of claim 3 , wherein the thin-film micromesh is expandable along the circumferential direction allowing the cylindrical shape thin-film micromesh device to expand radially increasing a diameter of the cylindrical shape thin-film micromesh device.5. The thin-film ...

MEDICAL DEVICE

A method for treating an aneurysm can include inserting a medical device partially in a first artery and partially in a third artery. The device can be expanded radially outwardly from a first position to a second position to engage an inner surface of the first artery and an inner surface of the third artery, so as to maintain a fluid pathway through said arteries. Further, the device can be positioned such that, when the device is in the second position, a porous membrane of the device is located at a neck of the aneurysm. 1. A medical device for treating a bifurcation or trifurcation aneurysm , in a patient , occurring at a first artery , the first artery and a second artery joining to a third artery , the device comprising:an expandable latticework frame having first and second struts that each define a radially outermost edge, a radially innermost edge, a circumferential strut width, and a wall thickness between the radially outermost and innermost edges; anda porous membrane that extends around and between the first and second struts, the membrane having a web portion that, between the first and second struts, extends only within a central region being (i) bounded radially between the radially outermost edges and the radially innermost edges of the first and second struts and (ii) bounded circumferentially between the first and second struts, the web portion defining a web thickness that is less than the wall thickness of the first or second struts;wherein the membrane is configured to (i) reduce blood supply into the aneurysm, and (ii) permit blood supply through pores of the membrane and into perforators and/or microscopic branches of the first artery so as not to inhibit blood supply functions of the perforators and/or microscopic branches.2. The device of claim 1 , wherein the pores are between 20 and 100 microns in size.3. The device of claim 1 , wherein a distance between adjacent pores of the membrane does not exceed 100 microns.4. The device of claim 2 ...

ANEURSYM OCCLUSION SYSTEM AND METHOD

An aneurysm occlusion system includes a device positionable within a cerebral blood vessel covering a neck of an aneurysm on the blood vessel. The device includes an expandable tubular element having a lumen surrounded by a sidewall including a plurality of gaps. When expanded, the tubular element includes longitudinal standards arrayed helically in a proximal to distal direction. The standards support struts and the gaps are defined between adjacent struts and are sufficiently large to permit delivery of embolic coils or other embolic materials therethrough. 1. A system for treatment of intracranial aneurysm comprising:a device for bridging the neck of an aneurysm of a cerebral vessel, said device comprising a tubular element including a plurality of standards, a plurality of bands connected to the standards, a longitudinal axis, a reduced-profile delivery configuration and a deployed configuration, wherein said standards are oriented at an angle to said longitudinal axis when said tubular element is in said deployed configuration so that the standards and the bands together define a plurality of helical spines;an introducer for introducing said tubular element into a vessel; anda delivery device for delivering embolic material into the aneurysm.2. The system according to wherein said angle is between 15° and 45°.3. The system of wherein the bands further comprise one or more V-struts claim 1 , wherein each V-strut comprises a first leg claim 1 , a second leg that is longer than said first leg claim 1 , and an apex between said legs.4. The system of wherein said standards comprise a width of between 0.0020 inch and 0.0050 inch.5. The system of wherein said bands further comprise one or more V-struts claim 1 , wherein each V-strut comprises a first leg claim 1 , a second leg claim 1 , and an apex between said legs claim 1 , said first leg further comprising an S-shaped connector disposed near claim 1 , but not on claim 1 , said apex.6. The system of wherein said ...

Stent And Stent Delivery Device

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer. 1. A stent delivery device comprising:a multi-lumen catheter containing a first lumen and a second lumen;the first lumen providing a passage way for a guidewire;the second lumen housing a core member;the core member having a proximal end and a distal end where the core member is connected to a pusher on the proximal end and an anchor member on the distal end;the anchor member releasably connected to a stent for inserting or retracting the stent, where pushing or pulling the pusher causes the anchor member to move while the multi-lumen catheter remains in a fixed position.2. The stent delivery device of claim 1 , wherein the multi-lumen catheter further comprises a third lumen connected to the anchor member and extending into the first lumen in a telescoping arrangement such that the third lumen is moveable in both directions as the core member is moved while the first lumen remains in a fixed position to provide a dedicated rapid exchange port for the guidewire.3. The stent delivery device of wherein the anchor member contains an elongated depression which holds the core member.4. The stent delivery device of wherein the anchor member includes a body that forms a backstop surface against which the stent can be pushed.5. The stent delivery device of wherein the anchor member includes a plurality of radially oriented posts.6. The stent delivery device of wherein the plurality of radially oriented posts have distal and proximal surfaces that are angled toward each other.7. The stent delivery device of wherein the stent includes a plurality of proximal loops and the ...

DEVICE AND METHOD FOR BRIDGING A NECK OF AN ANEURYSM

A system for removing a thrombus. The system includes an expandable device that maintains axially fixed engagement with the thrombus. The expandable device applies a first force to the thrombus according to surrounding vessel size. The expandable device applies a second force to the thrombus according to an increased vessel size to maintain axially fixed engagement. 1. A device for bridging a neck of an aneurysm , comprising:an expandable member positionable within a blood vessel at an opening of aneurysm to form a bridge across said opening; said expandable member configured to prevent coils contained within said aneurysm from entering said vessel, without arresting blood flow within said vessel;a push/pull wire coupled at least to a distal end of said expandable member, said push/pull wire configured to control expansion of said member when an axial force component is applied to a proximal end of said wire from outside the patient;wherein said expandable member is configured to expand to a diameter larger than a relaxed diameter of said member by manipulation of said push/pull wire.2. The device according to claim 1 , wherein said device further comprises an outer tube having a proximal end and a distal end claim 1 , said tube sized to be slidably disposed within a microcatheter claim 1 , and wherein said expandable member is coupled to a distal end of said tube.3. The device according to claim 2 , wherein said push/pull wire is fixed to said distal end of said expandable member claim 2 , said push/pull wire extending in a proximal direction through said outer tube and configured so that relative axial displacement of said push/pull wire with respect to said outer tube causes said expandable member to elongate axially and contract radially when said wire is moved distally with respect to said tube claim 2 , and to compress axially and expand radially when moved proximally with respect to said outer tube.4. The device according to claim 1 , wherein a ratio between ...

VASO-OCCLUSIVE DEVICES

A vaso-occlusion system for occluding an aneurysm includes a delivery catheter having a delivery lumen extending therethrough, a pusher member at least partially extending through the delivery lumen, and a vaso-occlusive device loaded within the delivery lumen, the vaso-occlusive device comprising an expandable braid formed out of a plurality of elongate braid filaments, the elongate braid elements having respective proximal end portions that are formed into a flexible transition section having a proximal end portion attached to a distal end of the pusher member and/or to an elongate central member coupled to, and extending distally of, the pusher member. 1. A vaso-occlusive device , comprising:an elongate central member; andan expandable braid having a main body section and a proximal transition section that extends proximally from the main body section to the elongate central member, the proximal transition section having a proximal end portion attached to the elongate central member,wherein the proximal transition section of the braid has a stiffness that is greater than a stiffness of the main body section.2. The vaso-occlusive device of claim 1 , wherein the main body section of the braid is formed out of a first number of elongate braid filaments claim 1 , and wherein the proximal transition section of the braid is formed out of a second number of elongate braid filaments that is greater than the first number.3. The vaso-occlusive device of claim 2 , wherein elongate braid filaments of the main body section are threaded with elongate filaments of the proximal transition section.4. The vaso-occlusive device of claim 2 , wherein elongate braid filaments of the main body section are bonded claim 2 , sutured or tied to elongate filaments of the proximal transition section.5. The vaso-occlusive device of claim 1 , wherein the main body section of the braid is formed out of a first plurality of elongate braid filaments claim 1 , each having a first diameter claim 1 ...

Embolic implant and method of use

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Systems and Methods for Magnetized Stent Having Growth-Promoting Properties

Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm. The magnetic region can serve to attract and position both residual red blood cells and magnetically nano-treated growth-promoting cells to the orifice area of the aneurysm. The outer circumference of the tubular elongated body can act as a floor or scaffold for regenerated smooth vascular muscle cells. In embodiments, the tissue nidus area can be provided on the exterior stent, while the magnetized region is provided on the interior stent, of a stent-in-stent structure. In embodiments, the exterior stent is made of biodegradable material which gradually dissolves or dissipates in situ. 1. A stent assembly , comprising:a tubular elongated body having an inner and outer surface, wherein the tubular elongated body comprises:a tissue nidus area positionable underneath an orifice of a vascular aneurysm; anda magnetized region, alignable with the tissue nidus area, for applying a magnetic field to the orifice of the vascular aneurysm to promote tissue growth across the orifice, wherein the tissue nidus area is located on the outer surface of the tubular elongated body and the magnetized region is located on an inner tubular mesh concentrically mounted inside the tubular elongated body.2. (canceled)3. The stent assembly of claim 1 , wherein the magnetized region comprises a magnetized region on the outer surface of the inner tubular mesh extending over a portion of the circumference of the inner tubular mesh.4. The stent assembly of claim 3 , wherein the portion of the circumference comprises at most one half of the circumference.5. The stent assembly of claim 4 , wherein the portion of the circumference comprises a circumscribed area corresponding to that of the orifice.6. The stent assembly of claim 1 , in which the ...

FLEXIBLE INTRA-VASCULAR ANEURYSM TREATMENT STENT

An intra-vascular aneurysm-treatment stent and a method for lowering pressure within an aneurysm bubble in a blood vessel. A stent coil is insertable into a blood vessel, the coil made of a material sufficiently flexible to move around curves, loops, and corners in the blood vessel. The stent coil is positioned in the blood vessel with selected stent coil portions proximate an opening into either a saccular aneurysm or a fusiform aneurysm. Blood in the lumen of the blood vessel flows past the leading edges and both over the outer surfaces, and under the inner surfaces. A portion of the blood inside the aneurysm becomes entrained with the blood flowing over the outer surfaces. At the trailing edges, the converging blood flows create eddies. 1. An intra-vascular aneurysm-treatment stent comprising:a flexible member, insertable into a blood vessel, with selected portions of the flexible member positioned proximate an opening in a wall of the blood vessel, and opening into an aneurysm bubble, the flexible member having an upstream proximal end, an opposite downstream distal end, a length between the proximal end and the distal end, and a longitudinal axis extending along the length, the selected portions of the flexible member each having a leading edge directed toward the proximal end, a trailing edge directed toward the distal end, and an outer surface and an inner substantially planar surface extending from proximate the leading edges to proximate the trailing edges, at least one of the selected portions having a first cross-section in a first plane parallel to the longitudinal axis, the inner substantially planar surface being located at or above a second plane perpendicular to the first plane and parallel to the longitudinal axis, a third plane perpendicular to the first plane and the second plane, the third plane intersecting the first cross-section between the leading edge and the trailing edge in the first cross-section, and the third plane intersecting the ...

Stent

A stent with varying porosity is described. The stent can be comprised of multiple stents attached together. A braided stent may have selected regions of increased thickness. The stent may be comprised of wires that are welded together at their ends in order to minimize vessel trauma. The stent may comprise a helically wound radiopaque wire wound through the stent. 1. A stent comprising:a tubular shape formed from at least one wire; said tubular shape having a first region that has a first porosity and a second region that has a second porosity that is higher than said first porosity.2. The stent of claim 1 , wherein said first region is woven with a first braid pattern and said second region is woven with a second braid pattern.3. The stent of claim 1 , wherein said first region is woven with a higher pick per inch than said second region.4. The stent of claim 1 , wherein said at least one woven wire has a larger diameter within said first region than in said second region.5. The stent of claim 1 , wherein said first region and said second region are formed by simultaneously weaving said at least one woven wire on a single stent mandrel.6. The stent of claim 1 , wherein said first region and said second region are separately woven and then longitudinally attached together to form said tubular shape.7. The stent of claim 6 , wherein said first region and said second region are welded together.8. The stent of claim 6 , wherein said first region and said second region are attached via a plurality of mechanical ties.9. The stent of claim 1 , wherein said first region further comprises a plurality of mechanical ties claim 1 , each of which connect a first stent wire and a second stent wire overlapping said first stent wire.10. The stent of claim 9 , wherein each of said plurality of mechanical ties further comprises a first coil having a first inner diameter and that is disposed around only said first stent wire.11. The stent of claim 10 , wherein each of said plurality ...

Alternative Use for Hydrogel intrasaccular Occlusion Device with a Spring for Structural Support

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention uses a modified hydrogel intrasaccular occlusion device designed to implement an endovascular treatment to ameliorating or eliminating aneurysm recurrence, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate endovascular treatment related difficulties.

THROMBORESISTANT COATINGS FOR ANEURYSM TREATMENT DEVICES

Disclosed are coating compositions, processes, and designs for endowing vascular devices with thromboresistant and endothelializing properties. Also disclosed are designs of vascular devices used as aneurysm treating devices for assisting in the delivery, packing, and maintenance of embolization coils within an aneurysm, particularly a neurovascular aneurysm. 1. A device for insertion into a blood vessel lumen for treatment of aneurysms , comprising:a generally cylindrical meshed section comprising a plurality of struts forming interstitial gaps between the struts and having a proximal face and a distal face and defining a device lumen extending along an axial direction from the proximal face to the distal face, the lumen configured to allow blood flow through the device; and wherein the proximal apex is radially aligned with the circumference of the proximal face or positioned radially outside the circumference of the proximal face, and', 'wherein the plurality of struts of the proximal tapered section extend from different points on the circumference of the proximal face in an axial and circumferential direction to the proximal apex, such that none of the plurality of struts cross through a cross-sectional area defined by the device lumen., 'a proximal tapered section comprising a plurality of struts extending from a circumference of the proximal face to a proximal apex,'}2. (canceled)3. (canceled)4. The device of claim 1 , wherein the plurality of struts of the generally cylindrical section and the proximal tapered section are formed from braided wires which are at least partially braided within the proximal tapered section.5. The device of claim 1 , wherein one or more of the plurality of struts of the proximal tapered section are inverted within the proximal tapered section such that one or more of the inverted struts bend radially outward and toward the proximal apex within the proximal tapered section and such that the proximal apex is positioned radially ...

Aneurysm Treatment Device And Method Of Use

An apparatus for treating vascular aneurysms includes an occlusive support device comprised of one or more support members. The occlusive device has, an end cap member and an anchoring member. The end cap member is comprised of at least one of one or more of the support members. The end cap member has openings and the end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings. The device is configured so that the occlusive members can be positioned in the blood vessel proximate the neck of a vascular aneurysm, the reactive material hydrates and increases the resistance to blood flow into the aneurysm, and the anchoring member anchors the device in the blood vessel without occluding flow through the blood vessel. 1. An apparatus for treating vascular aneurysms , comprising:an occlusive support device comprising one or more support members forming a first end portion and a second end portion and defining a lumen therethrough; andan end cap member at said first end portion of said occlusive support device;wherein said end cap member has openings and said end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings; andan anchoring member at said second end portion.2. The apparatus of wherein said end cap member comprises at least one of said one or more support members.3. The apparatus of wherein said end cap member comprises a support member formed in a circular shape of decreasing diameter.4. The apparatus of wherein said end cap member comprises a plurality of interwoven support members forming a fenestrated end cap.5. The apparatus of wherein said reactive material is applied to said end cap member.6. The apparatus of wherein said end cap member comprises a porous material.7. The apparatus of claim 1 , wherein said end cap is capable of increasing the resistance of blood flow therethrough.8. The ...

Alternative use for Hydrogel Intrasaccular Occlusion Device with Vertically Oriented Reinforcement Members for Structural Support

A device for endovascular treatment to ameliorate aneurysm recurrences by deploying a treatment mesh having a plurality of vertically oriented elongated support reinforcement elements that are substantially parallel and oriented upon a plane in communication with the mesh. Upon deployment, the array of distal ends of the support extensions and reinforcements are substantially oriented upon a plane, which plane is in substantially the same orientation as the opening of the aneurysm into which the device was deployed. The treatment mesh may incorporate a coating of hydrogel, optionally impregnated with pharmaceutical compounds.

Hybrid stent

A stent includes a high radial force segment and a highly flexible segment, where the diameters of the high radial force segment and the highly flexible segment are substantially the same. The stent may further be placed with an additional stent segment, where the additional stent segment has a radial force similar to the radial force of the highly flexible force segment.

METHODS AND APPARATUS FOR LUMINAL STENTING

Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow. 1. A flow-directing device implantable across an aneurysm in a blood vessel of a patient , the flow-directing device comprising:a proximal end;a distal end;a length extending between the proximal end and the distal end;a lumen extending the length; anda plurality of strands braided together, a first plurality of the strands formed of first materials comprising a cobalt-nickel alloy, and a second plurality of the strands formed of second materials different from the first materials, the second materials comprising a platinum-tungsten alloy;wherein the flow-directing device has a porosity between the strands configured to direct blood flow away from an aneurysm and to allow blood flow to branch vessels when placed in a blood vessel;wherein the flow-directing device is self-expandable from a compressed state to an expanded state;wherein the length of the flow-directing device in the expanded state is shorter than the length of the flow-directing device in the compressed state;wherein a diameter of each of the plurality of strands is between about 0.0005 inches and 0.0020 inches;wherein each of the plurality of strands comprises an inner surface and an outer surface, the outer surfaces comprising between about 20% and about 50% of a ...

ENDOVASCULAR IMPLANT

A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent. 110.-. (canceled)11. An intravascular implant having a radiopaque marker , the intravascular implant comprising:a proximal undulating ring on a proximal side of the intravascular implant comprising a plurality of proximal struts, the plurality of proximal struts comprising a plurality of first proximal struts and a plurality of second proximal struts, wherein each first proximal strut of the plurality of first proximal struts is connected to at least one second proximal strut of the plurality of second proximal struts, wherein a proximal end of each first proximal strut of the plurality of first proximal struts is connected to a proximal end of a second proximal strut of the plurality of second proximal struts to form a plurality of first proximal apices and a distal end of each first proximal strut of the plurality of first proximal struts is connected to a distal end of a second proximal strut of the plurality of second proximal struts to form a plurality of first distal apices, wherein at least one first proximal apex of the plurality of first proximal apices defines a proximal end of the intravascular implant;a distal undulating ring on a distal side of the intravascular implant comprising a plurality of distal struts, the plurality of distal struts ...

ENDOVASCULAR IMPLANT

A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent. 110.-. (canceled)11. A self-expanding intravascular implant comprising:a proximal undulating ring on a proximal side of the intravascular implant comprising a plurality of proximal struts, the plurality of proximal struts comprising a plurality of first proximal struts and a plurality of second proximal struts, wherein each first proximal strut of the plurality of first proximal struts is connected to at least one second proximal strut of the plurality of second proximal struts, wherein a proximal end of each first proximal strut of the plurality of first proximal struts is connected to a proximal end of a second proximal strut of the plurality of second proximal struts to form a plurality of first proximal apices and a distal end of each first proximal strut of the plurality of first proximal struts is connected to a distal end of a second proximal strut of the plurality of second proximal struts to form a plurality of first distal apices, wherein at least one first proximal apex of the plurality of first proximal apices defines a proximal end of the intravascular implant;a distal undulating ring on a distal side of the intravascular implant comprising a plurality of distal struts, the plurality of distal struts comprising a plurality of first distal ...

ENDOVASCULAR IMPLANT

A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent. 110.-. (canceled)11. A system for delivering a vascular prosthesis , comprising: a plurality of annular recesses disposed adjacent the distal end of the elongate body;', 'a plurality of proximal shoulders;', 'a plurality of distal shoulders, wherein each annular recess of the plurality of annular recesses is situated between one proximal shoulder of the plurality of proximal shoulders and one distal shoulder of the plurality of distal shoulders, wherein each shoulder of the pluralities of proximal and distal shoulders has a radially extending face perpendicular to the longitudinal axis; and', 'a plurality of cylindrical regions, wherein each cylindrical region of the plurality of cylindrical regions is formed by a proximal shoulder of the plurality of proximal shoulders at an adjacent first annular recess of the plurality of annular recesses and a distal shoulder of the plurality of distal shoulders at an adjacent second annular recess of the plurality of annular recesses, wherein each cylindrical region of the plurality of cylindrical regions has an outer diameter greater than an outer diameter of the adjacent first and second annular recesses of the plurality of annular recesses and comprises an annular radiopaque marker band;, 'an elongate body ...