УСТРОЙСТВО И СПОСОБ ДЛЯ РАБОТЫ ПОСЛЕДОВАТЕЛЬНОГО ДАТЧИКА ВОЛНОВОГО ФРОНТА БОЛЬШОГО ДИОПТРИЙНОГО ДИАПАЗОНА РЕАЛЬНОГО ВРЕМЕНИ

1. Датчик волнового фронта, содержащий:источник 172 света, сконфигурированный, чтобы подсвечивать глаз субъекта;детектор 122;первый элемент 112 отклонения пучка, сконфигурированный, чтобы перехватывать пучок волнового фронта, возвращенный от глаза субъекта, когда глаз субъекта подсвечивается источником света, и сконфигурированный, чтобы направлять часть волнового фронта от глаза субъекта через апертуру к детектору; иконтроллер, связанный с источником света и элементом отклонения пучка, сконфигурированный для управления элементом отклонения пучка, чтобы отклонять и проецировать различные участки части кольцевой окружности волнового фронта от глаза субъекта через апертуру, и дополнительно сконфигурированный для импульсной модуляции источника света с частотой запуска, чтобы дискретизировать выбранные части кольцевой окружности на детекторе.2. Датчик волнового фронта по п. 1, причем контроллер дополнительно сконфигурирован для увеличения частоты запуска, чтобы увеличивать плотность дискретизации части кольцевой окружности.3. Датчик волнового фронта по п. 1, причем контроллер дополнительно сконфигурирован для сдвига по фазе времени запуска, чтобы сдвигать по углу местоположения частей, дискретизируемых детектором.4. Датчик волнового фронта по п. 1, причем контроллер сконфигурирован для управления элементом отклонения пучка, чтобы изменять радиус дискретизируемой части кольцевой окружности волнового фронта, так что набор кольцевых окружностей различных радиусов дискретизируется детектором.5. Датчик волнового фронта по п. 1, причем контроллер сконфигурирован для управления элементом отклонения пучка, чтобы ограничивать РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61B 3/10 (13) 2015 121 415 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015121415, 06.11.2013 (71) Заявитель(и): КЛЭРИТИ МЕДИКАЛ, СИСТЕМЗ ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: 07.11.2012 US 61/723,531 (85) Дата начала рассмотрения ...

УСТРОЙСТВО И СПОСОБ ДЛЯ РАБОТЫ ПОСЛЕДОВАТЕЛЬНОГО ДАТЧИКА ВОЛНОВОГО ФРОНТА БОЛЬШОГО ДИОПТРИЙНОГО ДИАПАЗОНА РЕАЛЬНОГО ВРЕМЕНИ

1. Устройство, содержащее:позиционно-чувствительный детектор 122, сконфигурированный для вывода последовательности позиционно-чувствительных сигналов, при этом каждый позиционно-чувствительный сигнал указывает отклонение центроида выборки волнового фронта от опорной точки на детекторе, причем выборкой волнового фронта является выборка части волнового фронта в форме кольцевой окружности падающего волнового фронта, возвращенного от глаза субъекта, исистему 710, 750 обработки, связанную с позиционно-чувствительным детектором, чтобы принимать последовательность позиционно-чувствительных сигналов, причем система обработки сконфигурирована, чтобы вычислять последовательность координат отклонения, указывающих отклонение каждого центроида, вычислять центральную точку последовательности координат отклонения центроида, ассоциировать последовательность координат отклонения с эллипсом, центрированным в центральной точке, причем последовательность координат отклонения центроида подогнана к эллипсу, выраженному в декартовых координатах U, V, причем эллипс имеет большую ось амплитуды=а и малую ось амплитуды=b, с центром эллипса, находящимся в точке U=0, V=0, и каждым отклонением центроида, имеющим координаты U(t)=a•cos(t), V(t)=b•sin(t), где t=зависимая от времени фаза приема набора последовательно принимаемых координат отклонения центроида, и где эллипс является кругом, если амплитуды большой и малой осей равны, определять ось астигматизма на основе угловой ориентации большой и малой осей и определять относительную величину расходимости и сходимости на основе относительных величин а и b.2. Устройство по п. 1, причем система обработки дополнительно РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61B 3/10 (13) 2015 121 412 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015121412, 06.11.2013 (71) Заявитель(и): КЛЭРИТИ МЕДИКАЛ СИСТЕМЗ, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: 07.11.2012 US 61/723,531 (85) Дата ...

In situ UV/RIBOFLAVIN ocular treatment system

LASER APPARATUS TO THERMAL CORNEA/CALLOSITY PLASTICS

COMBINED HEATING UP WITH MICROWAVES AND COOLING OF THE SURFACE OF THE KORNEA

DEVICE FOR THE TREATMENT OF KOLLAGEN

SYSTEM FOR THE CHANGE OF VISUAL ACUITY BY THERMAL MEANS

System and method for defining and controlling LTK and other surgical eye procedures to produce little or no stromal collagen shrinkage

IMPROVED METHOD AND APPARATUS FOR PERFORMING CORNEAL RESHAPING TO CORRECT OCULAR REFRACTIVE ERRORS

Systems and methods for providing anatomical flap centration for an ophthalmic laser treatment system

Embodiments of this invention relate to systems and methods for providing anatomical flap centration for an ophthalmic laser treatment system. In one embodiment, the laser surgery system, having an imaging system and a suction ring coupled with a patient interface, captures a digital image of a subject's eye and identifies an optimum treatment placement of the corneal flap using anatomical markers as reference points.

System for performing eye surgery with simultaneous display of graphical information for flap and ablation

The disclosure relates to systems and methods for performing eye surgery in which a single image that simultaneously presents a graphical representation of a planned or actual flap location superimposed with a graphical representation of a planned or actual area of ablation is used.

Method and system for laser thermokeratoplasty

Method and apparatus for exposing a human eye to a controlled pattern of radiation spots

APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR

An apparatus including a position sensing detector (122) and a processing system (710, 750), with the processing system (710, 750) configured to determine axis of astigmatism and cylinder and sphere diopter values of a subject eye.

APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR

A wavefront sensor using a calibration wave generator (199/299) to calculate correction factors to be applied to ratiometric combinations of position sensor (122) output signals to determine real centroid deflection values.

APPARATUS AND METHOD FOR PERFORMING LASER THERMAL KERATOPLASTY WITH MINIMIZED REGRESSION

This invention is a non-contact apparatus and method for performing laser thermal keratoplasty capable of scanning of treatment areas with shapes that reduce regression. The apparatus includes laser sources (70, 78, 40), a projection optical system, observation system, and control system. The projection system uses two steering mirrors (56, 58) to control laser beam position on the cornea. This projection system enables precise control of the area of corneal heat shrinkage using relatively low-powered lasers, such as diode lasers. Desired changes in corneal refractive power are produced by selected patterns of photothermal shrinkage of corneal collagen tissue. The selected patterns are arrangements of oblong shapes that are preferably tapered at the ends of the long axis. The oblong shape and tapering distribute tension in the cornea over a wider area of collagen shrinkage and improve the stability of refractive correction. The long axes of the oblong treatment areas are preferably oriented ...

SHORT PULSE MID-INFRARED PARAMETRIC GENERATOR FOR SURGERY

A laser parametric generator for surgical applications is disclosed which utilizes short-pulse, mid-infrared radiation. The mid-infrared radiation may be produced by a pump laser source (20), such as a neodymium-doped laser, which is parametrically downconverted in a suitable nonlinear crystal (15) to the desired mid-infrared range. The short pulses reduce unwanted thermal effects and changes in adjacent to potentially submicron levels. The parametrically converted radiation source preferably produces pulse durations shorter than 25 ns at or near 3.0 .mu.m but preferably close to the water absorption maximum associated with the tissue. The down-conversion to the desired mid-infrared wavelength is preferably produced by a nonlinear crystal (15) such as KTP or its isomorphs. In one embodiment, a non-critically phasedmatched crystal is utilized to shift the wavelength from a near-infrared laser source emitting at or around 880 to 900 nm to the desired 2.9 to 3.0 .mu.m wavelength range. A fiber ...

DEVICE TO CARRY OUT A RECTILINEAR INCISION IN AN EYE TO BE TREATED

SYSTEM AND METHOD FOR DEFINING AND CONTROLLING LTK AND OTHER SURGICAL EYE PROCEDURES TO PRODUCE LITTLE OR NO STROMAL COLLAGEN SHRINKAGE

One or more treatment parameters are determined for a cornea reshaping procedure. The one or more treatment parameters are selected so as to reduce an amount of collagen shrinkage in a cornea of a patient's eye caused by the cornea reshaping procedure. For example, the one or more treatment parameters could be selected so as to minimize an amount of stromal collagen shrinkage in the cornea of the patient's eye caused by the cornea reshaping procedure. As another example, the cornea reshaping procedure could include irradiating multiple spots on the cornea of the patient's eye, where each spot is associated with an amount of stromal collagen. The one or more treatment parameters could be selected so that no more than 1% or 5% of the stromal collagen in the irradiated spots undergoes clinically significant shrinkage as a result of the cornea reshaping procedure. COPYRIGHT KIPO & WIPO 2010 ...

method of increasing the eye accommodating, and, a system for utilization in increasing the ability to accommodate a [...]

APPARATUS FOR EYE LASER SURGERY FOR PERFORMING A TRANSEPITHELIAL PHOTOREFRACTIVE KERATECTOMY

Apparatus and method for operating a real time large diopter range sequential wavefront sensor

An wavefront including a light source for providing a light beam to illuminate a subject eye and a beam deflecting to deflect the light beam to compensate transverse movement of the subject eye. A second beam deflecting element scans the beam around a small portion of the retina to dissipate energy.

SYSTEM AND METHOD FOR POSITIONING AN EYE THERAPY DEVICE

A system for aligning an eye therapy instrument over a selected area or feature of an eye provides an attachment element that is removably attached to a surface of an eye. A receiving element is coupled to the attachment element and movable relative to the attachment element. The receiving element includes a coupling element configured to operably couple an eye therapy instrument to the receiving element and adjustably move the eye therapy instrument into a selected position with respect to the attachment element. The system makes adjustments to ensure accurate delivery of treatment from the eye therapy device to areas of the eye. In one embodiment, the receiving element allows lateral adjustments to be made along one or more axes. Additionally or alternatively, the receiving element allows angular or rotational adjustments to be made about one or more axes.

METHOD AND APPARATUS FOR MAKING IMPROVED SURGICAL INCISIONS IN CORRECTIVE EYE SURGERY

A method and apparatus for making improved surgical incisions in corrective eye surgery are provided. It was observed that a uniform elongated AK (or LRI) incision provides a non-uniform corrective effect due to non-uniform post-surgical relaxation of ophthalmic tissue. The method and apparatus leverage this observation to provide for creation of a surgical incision that is structured to be non-uniform along its length in such a manner as to at least partially counteract an expected variation in ophthalmic tissue relaxation to provide overall increased uniformity of corrective effect. An automated laser surgery system includes a laser control system configured to control laser delivery to cause selective ablation of ophthalmic tissue to provide an elongated structured incision that varies along its length in at least one of a depth, a profile, a width, and an angle of attack relative to a surface of the ophthalmic tissue.

APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR

A wavefront sensor includes a light source (172) configured to illuminate a subject eye, a detector (122), a first beam deflecting element (112/412) configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source (172) and configured to direct a portion of the wavefront from the subject eye through an aperture (118/418) toward the detector (122) and a controller, coupled to the light source (172) and the first beam deflecting element (112/412), configured to control the first beam deflecting element (112/412) to deflect and project different portions of an annular ring portion (444/494) of the wavefront from the subject eye through the aperture (118/418) and further configured to pulse the light source (172) at a firing rate to sample selected portions of the annular ring (118/418) at the detector.

APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR

An apparatus including a wavefront sensor including a light source (172) configured to illuminate a subject eye, a detector (122), an image sensor (162) configured to output an image of the subject eye, a first beam deflecting element (112) configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source (172) and configured to direct a portion of the wavefront from the subject eye through an aperture (118) toward the detector (122), and a controller coupled to the light source (172), the image sensor (162) and the beam deflecting element (112), configured to process the image to determine transverse movement of the subject eye and to control the beam deflecting element (112) to deflect and project through the aperture (118) portions of an annular ring portion of the wavefront and further configured to pulse the light source (172) at a firing rate to sample selected portions of the annular ring at the detector (122), to process ...

CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1 x 10-4 Pa*m3 to about 5 x 10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

Compound modulation transfer function for laser surgery and other optical applications

Methods, devices, and systems establish an optical surface shape that mitigates or treats a vision condition in a patient. An optical surface shape for a particular patient can be determined using a set of patient parameters for the specific patient by using a compound modulation transfer function (CMTF). The compound modulation transfer function can include a combination of modulation transfer functions (MTF's) at a plurality of distinct frequencies.

Photochemical tissue bonding

Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.

Method and apparatus for generating localized hyperthermia

Ultrasound generating methods and apparatus are disclosed for producing controlled, localized hyperthermia in a selected heating zone of human tissue, utilizing at least one ultrasound transducer, preferably driven by sinusoidal excitation signals in a continuous wave or quasi-continuous wave mode to generate ultrasound. The temperature in the heated zone can be controlled by selecting the power, duration and frequency of the ultrasound. The penetration of the ultrasound, and thus the depth and volume of the target zone, can be controlled by selecting the excitation frequencies so to confine the absorption of the ultrasound beam in the target tissue. The invention is particularly useful in inducing controlled collagen shrinkage in corneal tissue to effective thermokeratoplasty (heat induced modification of the shape of the cornea).

Apparatus and method for shrinking collagen

The present invention provides a device, a system, and associated methods for advantageously treating bodily tissues containing collagen, such as the cornea. The device is a topical device that, when placed over the target tissue, defines a space between an inner surface of the device and the tissue. The radiation-transparent device allows radiation to pass therethrough to the tissue during the radiation treatment. The device is believed to reduce heat loss, such as evaporative heat loss, from the tissue, thereby improving the tissue-heating efficiency of the radiation treatment. Typical radiation treatment parameters may thus be adjusted to provide a more gentle, yet highly efficient treatment using the inventive device. The gentle treatment reduces the likelihood of thermally traumatizing the treated tissue. While the invention has particular application in the area of corneal treatment, it may be used to prepare other tissues or substrates.

Devices and methods for novel retinal irradiance distribution modification to improve and restore vision without producing corneal vitrification

Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.

Patent RU2015135997A3

`” ВУ“? 2015135997” АЗ Дата публикации: 27.03.2019 Форма № 18 ИЗИМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение ж 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2015135997/14(055114) 25.08.2015 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 192014012675.7 26.08.2014 РЕ Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) КРОССЛИНКИНГ ТКАНЕЙ ГЛАЗНОГО ЯБЛОКА Заявитель: УЭЙВЛАЙТ ГМБХ, ОЕ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) Аб1Е 9/008 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) АбТЕ 9/007 - 9/008 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): СТРО, СМГРА, РЕРАТБЗ пес, РУУРТ, Е-ГлЬгагу, ЕАРАТБУ, Езрасепе, Соозе, }]-Р]а(Рав, КРКВ5, РАТЕМТЗСОРЕ, Ра еагсп, РиБМед, КАЧРТО, КатЫег, 5СОРОУ, ОЗРТО, М\МопдУ/1деЗслепсе, Уапдех, БД "Российская медицина", БД ВИНИТИ, БЕН РАН, РГБ 6. ДОКУМЕНТЫ, ОТНОСЯЩИЕСЯ К ПРЕДМЕТУ ПОИСКА Кате- Наименование ...

МОДУЛЬНЫЙ АДАПТЕР ДЛЯ ПАЦИЕНТА ДЛЯ ЛАЗЕРНОГО УСТРОЙСТВА ДЛЯ ГЛАЗА

УСТРОЙСТВО ДЛЯ ЛАЗЕРНОЙ ХИРУРГИИ ГЛАЗА ДЛЯ ВЫПОЛНЕНИЯ ТРАНСЭПИТЕЛИАЛЬНОЙ ФОТОРЕФРАКЦИОННОЙ КЕРАТЭКТОМИИ

Vorrichtung und Verfahren zur Durchführung einer Thermokoagulation

DEVICE FOR THE CORNEA/CALLOSITY SHAPING FOR CORRECTING REFRACTION ERRORS OF THE EYE

PROFILES FOR TRANSFERRED ABLATION WITH THE TREATMENT OF IRREGULAR ASTIGMATISM

SHORTPULSED PARAMETRIC CENTRAL INFRARED GENERATOR TO THE SURGERY

Laser system for reshaping the cornea

Cross-linking of eye tissue

Abstract The present disclosure relates to the cross-linking of eye tissue. Embodiments of the 5 disclosure relate to the activation of a photosensitizer and/or nanoparticles for the cross-linking of eye tissue.

System for performing eye surgery with simultaneous display of graphical information for flap and ablation

The disclosure relates to systems and methods for performing eye surgery in which a single image that simultaneously presents a graphical representation of a planned or actual flap location superimposed with a graphical representation of a planned or actual area of ablation is used.

Apparatus and method for operating a real time large diopter range sequential wavefront sensor

A wavefront sensor including a wavefront scanning module (615) configured to output wavefront tilt measurements of a wavefront beam returned from a subject eye, a biometric/anatomic measurement device (197) configured to output biometric/anatomic measurements of the subject eye, and a processing system coupled to the scanning module (615) and the biometric/anatomic measurement device (197) configured to process biometric/anatomic measurements output during a surgical procedure to determine eye status information and to concurrently output eye status information and wavefront tilt information during the surgical procedure.

Apparatus and method for operating a real time large diopter range sequential wavefront sensor

A sequential wavefront sensor including a light source (172), a beam deflecting element (112), a position sensing detector (122) configured to output a plurality of output signals and a plurality of composite transimpedance amplifiers (see Figure 11) each coupled to receive one of the detector output signals. The output of each composite transimpedance amplifier is phase-locked to a light source drive signal and a beam deflecting element drive signal.

CORNEAL TOPOGRAPHY MEASUREMENT AND ALIGNMENT OF CORNEAL SURGICAL PROCEDURES

Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

SYSTEMS AND METHODS FOR PROVIDING ANATOMICAL FLAP CENTRATION FOR AN OPHTHALMIC LASER TREATMENT SYSTEM

Embodiments of this invention relate to systems and methods for providing anatomical flap centration for an ophthalmic laser treatment system. In one embodiment, the laser surgery system, having an imaging system and a suction ring coupled with a patient interface, captures a digital image of a subject's eye and identifies an optimum treatment placement of the corneal flap using anatomical markers as reference points.

SYSTEM AND METHOD FOR LASER CORNEAL INCISIONS FOR KERATOPLASTY PROCEDURES

A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea.

METHOD AND APPARATUS FOR MODIFICATIONS OF VISUAL ACUITY BY THERMAL MEANS

This invention is a thermo-keratoplasty system and method for locally heatin g and reshaping a cornea in a manner that produces a minimal regression of the corneal correction. The system includes a probe (1 2) that is coupled to a power source which can provide current at a predetermined power, frequency and time duration. The probe (12) has a sharp tip (36) that is inserted into the stroma of the cornea (48). The tip has an insulated stop that controls the depth of tip penetration. Current flows into the cornea through the probe tip to locally heat and denature the corneal tissue. The denatured tissue causes a subseque nt shrinkage of the cornea. A pattern of denatured areas can be created around the cornea to correct the vision of the eye.

Apparatus and method for operating a real time large diopter range sequential wavefront sensor

An apparatus including a position sensing detector and a processing system, with the processing system configured to determine axis of astigmatism and cylinder and sphere diopter values of a subject eye.

EYE THERAPY SYSTEM

Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

PHOTOCHEMICAL TISSUE BONDING

Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair.

INTEGRATED SURGICAL MICROSCOPE AND WAVEFRONT SENSOR

A wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated wavefront measurements of a patient's eye while the patient remains on an operating table in the surgical position. The device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap. The inclusion of lightweight, compact diffractive optical components in the wavefront sensor allows the integrated device to be supported on a balancing mechanism above a patient's head during a surgical procedure. As a result, the need to reposition the device and/or the patient between measuring optical properties of the eye and performing surgical procedures on the eye is eliminated. Many surgical procedures may be improved or enhanced using the integrated device, including but not limited to cataract surgery, Conductive Keratoplasty, Lasik surgery, and corneal corrective surgery.

Thermokeratoplasty system with a power supply that can determine a wet or dry cornea

A power supply for a thermokeratoplasty system. The power supply can be connected to an electrode and a return element that are both coupled to a cornea. The power supply can perform a test routine to determine whether the cornea is too “wet” or too “dry”.

System for automatically detecting eye corneal striae using projected and reflected shapes

An automated eye corneal striae detection system for use with a refractive laser system includes a cornea illuminator, a video camera interface, a computer, and a video display for showing possible eye corneal striae to the surgeon. The computer includes an interface to control the corneal illuminator, a video frame grabber that extracts images of the eye cornea from the video camera, and is programmed to detect and recognize eye corneal striae. The striae detection algorithm finds possible cornea striae, determines their location, or position, on the cornea and analyzes their shape. After all possible eye corneal striae are detected and analyzed, they are displayed for the surgeon on an external video display. The surgeon can then make a determination as to whether the corneal LASIK flap should be refloated, adjusted or smoothed again.

System for scanning a surgical laser beam

In a laser beam delivery system for a surgical laser beam, steering and scanning of the laser beam along the target in transverse (X and Y) directions is accomplished in a mechanically simple and fast-responding manner. Closely adjacent to the objective lens assembly of the delivery system is a pair of prisms, i.e. a Risley prism or Herschel prism, positioned on the axis of the approaching laser beam. The two prisms, closely spaced, are mounted on separate rotating stages whereby they may be individually rotated about the beam axis. When the prisms are co-rotated, circular scans are produced on the target, in diameters depending on the angular phase between the prisms. Counter rotation of the prisms at equal and opposite speeds will produce a diametric line scan on the target. Any desired complex scan pattern can be achieved using combinations of rotations of the two prisms. Axial compactness and proximity to the objective lens assembly assure that virtually all of the angularly emerging ...

Method and apparatus for modifications of visual acuity by thermal means

A thermokeratoplasty system and method for locally heating and reshaping a cornea in a manner that produces a minimal regression of the corneal correction. The system includes a probe that is coupled to a power source which can provide a predetermined power, frequency and time duration that creates a thermal profile within the cornea which extends from the epithelium into the corneal stroma. The electrical return of the probe is a lid speculum which maintains the eye lids in an open position. The probe is placed into contact with the cornea and energy is transferred from the power source to the eye, through the lid speculum and back to the power source. The energy from the power supply is focused by a probe tip that locally heats and denatures the cornea, and causes a subsequent shrinkage of corneal tissue. A pattern of denatured areas can be created around the cornea to correct the vision of the eye. It has been found that power no greater than 1.2 watts, for a duration no greater than 1.0 seconds, will sufficiently induce corneal shrinkage without significant regression of the visual acuity correction of the eye. The probe may have an electronic circuit which prevents usage of the probe after a predetermined number of procedures.

Method and system for modifying eye tissue and intraocular lenses

A system for ophthalmic surgery includes a laser source configured to deliver an ultraviolet laser beam comprising laser pulses having a wavelength between 320 nm and 370 nm to photodecompose one or more intraocular targets within the eye with chromophore absorbance. The pulse energy, the pulse duration, and the focal spot are such that an irradiance at the focal spot is sufficient to photodecompose the one or more intraocular targets without exceeding a threshold of formation of a plasma and an associated cavitation event. An optical system operatively coupled to the laser source and configured to focus the ultraviolet laser beam to a focal spot and direct the focal spot in a pattern into the one or more intraocular targets. The optical system focuses the laser beam at a numerical aperture that provides for the focal spot to be scanned over a scan range of 6 mm to 10 mm.

PHARMACEUTICAL OPHTHALMIC COMPOSITIONS AND METHODS FOR FABRICATING THEREOF

Pharmaceutical ophthalmic compositions are described, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial agent (such as moxifloxacin), a therapeutically effective quantity of an anti-inflammatory agent (such as prednisolone), a combination of at least two solubilizing and suspending agents (of which one is a non-ionic polyoxyethlene-polyoxypropylene block copolymer), and a carrier. Methods for fabricating the compositions and using them are also described.

METHOD AND APPARATUS FOR TREATMENT OF OCULAR TISSUE USING COMBINED MODALITIES

A method is provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as pen-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that enables cross-linking (CXL) therapy to be combined with thermal therapy.

METHOD OF TREATING THE EYE USING CONTROLLED HEAT DELIVERY

The present invention relates to a device for treating the eye, including a body portion configured to be positioned adjacent the exterior surface of the cornea and a heating means for heating the body portion to a predetermined temperature to affect at least one of the following: facilitation of the escape of aqueous humor from the eye and substantially preventing coagulation of the corneal tissue, while substantially destroying tumor cells.

Photochemical tissue bonding

Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.

Femtosecond laser system and methods for photorefractive keratectomy

Embodiments of this invention generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incision. In an embodiment, an ophthalmic surgical laser system comprises a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, an XY-scan device to deflect the pulsed laser beam, a Z-scan device to modify a depth of a focus of the pulsed laser beam, and a controller configured to form a top lenticular incision and a bottom lenticular incision of a lens in the subject's eye, or just a bottom lenticular incision.

DEVICE, SYSTEM, AND METHOD FOR EPITHELIUM PROTECTION DURING CORNEA RESHAPING

SYSTEM FOR SCANNING A SURGICAL LASER BEAM

In a laser beam delivery system for a surgical laser beam, steering and scanning of the laser beam along the target (20) in transverse (X and Y) directions is accomplished in a mechanically simple and fast-responding manner. Closely adjacent to the objective lens assembly (24) of the delivery system is a pair of prisms (12, 14), i.e. a Risley prism or Herschel prism, positioned on the axis (16) of the approaching laser beam (18). The two prisms are mounted on separate rotating stages whereby they may be individually rotated about the beam axis. Co-rotation of the prisms produces circular scans, in diameters depending on the angle between the prisms. Counter rotation of the prisms at equal speeds will produce a diametric line scan. Any desired complex scan pattern can be achieved using combinations of rotations of the prisms. Axial compactness and proximity to the objective lens assembly assure that virtually all of the angularly emerging beam from the prism pair passes through the objective ...

СПОСОБ И УСТРОЙСТВО ДЛЯ ОБЪЕДИНЕНИЯ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ КАТАРАКТЫ С ХИРУРГИЧЕСКИМ ЛЕЧЕНИЕМ ГЛАУКОМЫ ИЛИ АСТИГМАТИЗМА

Изобретение относится к медицине. Универсальная офтальмологическая хирургическая система содержит: систему формирования изображений, сконфигурированную с возможностью поддержки определения целевой области при катаракте в хрусталике глаза; лазер, выполненный с возможностью подачи лазерных импульсов для лечения катаракты, чтобы выполнить фотодеструкцию участка определенной целевой области при катаракте. При этом система формирования изображений сконфигурирована также с возможностью поддержки определения целевой области при глаукоме в периферической области глаза; и лазер выполнен также с возможностью подачи лазерных импульсов для лечения глаукомы, чтобы создать один или более разрезов в целевой области при глаукоме посредством фотодеструкции. Причем лазерные импульсы для лечения катаракты и лазерные импульсы для лечения глаукомы подают при комплексной хирургической операции. 18 з.п. ф-лы, 26 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61F 9/008 (13) 2 580 749 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013103098/14, 23.06.2011 (24) Дата начала отсчета срока действия патента: 23.06.2011 (72) Автор(ы): КУРТЦ Рональд М. (US), ЮХАШ Тибор (US) (73) Патентообладатель(и): АЛЬКОН ЛЕНСКС, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.07.2014 Бюл. № 21 R U 24.06.2010 US 12/823,072 (45) Опубликовано: 10.04.2016 Бюл. № 10 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.01.2013 2 5 8 0 7 4 9 (56) Список документов, цитированных в отчете о поиске: US 2004215175 A1, 28.10.2004. US2009137993 A1, 28.05.2009. WO 2007043052, 19.04.2007. US 5549596, 27.08.1996. US 20070173795 A1, 26.07.2007;US 5439462 A1, 08.08.1995. RU 2308215 C1, 20.10.2007.. US 2011/041677 (23.06.2011) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 5 8 0 7 4 9 WO 2011/163508 (29.12.2011) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО " ...

СПОСОБ И УСТРОЙСТВО ДЛЯ УСКОРЕННОЙ ОРТОКЕРАТОЛОГИИ (ВАРИАНТЫ)

Изобретение относится к области медицины, а именно к способам и устройствам для придания роговице формы, необходимой для исправления дефектов рефракции. Способ включает этапы размягчения роговицы с помощью размягчающего агента, приложения шаблона для изменения формы роговицы до желательного кифоза и быстрой стабилизации тканей роговицы так, что роговица сохраняет свою новую конфигурацию. Химический размягчающий агент, такой как глутаровый ангидрид, наносится на роговицу для ее размягчения. К роговице прикладывают шаблон заранее заданных кривизны и конфигурации. К шаблону прикладывают давление. Шаблон удерживают на листе во время действия такого стабилизирующего агента, как источник ультрафиолетового света, расположенный над шаблоном. Ультрафиолетовый свет подают на роговицу. Стабилизирующий агент стабилизирует ткань роговицы так, что роговица сохраняет свою форму после удаления шаблона. 4 с. и 26 з.п. ф-лы, 17 ил.

СПОСОБ И УСТРОЙСТВО ДЛЯ ОБЪЕДИНЕНИЯ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ КАТАРАКТЫ С ХИРУРГИЧЕСКИМ ЛЕЧЕНИЕМ ГЛАУКОМЫ ИЛИ АСТИГМАТИЗМА

... 1. Универсальная офтальмологическая хирургическая система, содержащая:систему формирования изображений, сконфигурированную с возможностью поддержки определения целевой области при катаракте в хрусталике глаза;универсальный лазер, выполненный с возможностью подачи лазерных импульсов для лечения катаракты, чтобы выполнить фотодеструкцию участка определенной целевой области при катаракте; при этомсистема формирования изображений сконфигурирована также с возможностью поддержки определения целевой области при глаукоме в периферической области глаза; иуниверсальный лазер выполнен также с возможностью подачи лазерных импульсов для лечения глаукомы, чтобы создать один или более разрезов в целевой области при глаукоме посредством фотодеструкции; причемлазерные импульсы для лечения катаракты и лазерные импульсы для лечения глаукомы подают при комплексной хирургической операции.2. Универсальная офтальмологическая хирургическая система по п.1, в которой:универсальный лазер выполнен с возможностью подачи ...

УСТРОЙСТВО И СПОСОБ ДЛЯ РАБОТЫ ПОСЛЕДОВАТЕЛЬНОГО ДАТЧИКА ВОЛНОВОГО ФРОНТА БОЛЬШОГО ДИОПТРИЙНОГО ДИАПАЗОНА РЕАЛЬНОГО ВРЕМЕНИ

1. Датчик волнового фронта, содержащийисточник 172 света, сконфигурированный для вывода светового пучка, чтобы подсвечивать глаз субъекта;позиционно-чувствительный детектор 122, имеющий множество детекторных элементов, сконфигурированных для вывода множества выходных сигналов, указывающих уровень сигнала падающего света на каждом детекторном элементе;первый элемент 112 отклонения пучка, сконфигурированный для перехвата пучка волнового фронта, возвращенного от глаза субъекта, когда глаз субъекта подсвечивается источником света, и сконфигурированный для направления части волнового фронта от глаза субъекта через апертуру к детектору, где часть волнового фронта, направленного через апертуру, образует пятно на детекторе с амплитудой отклонения центроида пятна от опорной точки на детекторе, приближенно указанной логометрической комбинацией уровней выходных сигналов, причем амплитуда отклонения указывает степень наклона или сходимости или расходимости части волнового фронта от плоской волны;генератор 164 опорного волнового фронта, сконфигурированный для генерации калибровочного волнового фронта, эквивалентного волновому фронту, возвращенному от глаза субъекта, и имеющего заданную степень сходимости или расходимости от плоской волны, причем отклонение центроида калибровочного волнового фронта на позиционно-чувствительном детекторе является реальным отклонением центроида для заданной сходимости или расходимости; иблок обработки, связанный с источником света, элементом отклонения пучка и позиционно-чувствительным детектором, сконфигурированный для управления элементом отклонения пучка для отклонения РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61B 3/10 (13) 2015 121 427 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015121427, 06.11.2013 (71) Заявитель(и): КЛЭРИТИ МЕДИКАЛ СИСТЕМЗ, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: 07.11.2012 US 61/723,531 (85) Дата начала рассмотрения заявки PCT на национальной ...

УСТРОЙСТВО И СПОСОБ ДЛЯ РАБОТЫ ПОСЛЕДОВАТЕЛЬНОГО ДАТЧИКА ВОЛНОВОГО ФРОНТА БОЛЬШОГО ДИОПТРИЙНОГО ДИАПАЗОНА РЕАЛЬНОГО ВРЕМЕНИ

... 1. Датчик волнового фронта, содержащиймодуль 615 сканирования волнового фронта, сконфигурированный для вывода измерений наклона волнового фронта пучка волнового фронта, возвращенного от глаза субъекта;устройство 197 биометрических/анатомических измерений, сконфигурированное для вывода биометрических/анатомических измерений глаза субъекта; исистему 710, 750 обработки, связанную с модулем сканирования и устройством биометрических/анатомических измерений, сконфигурированную для обработки биометрических/анатомических измерений, выводимых во время хирургической процедуры, чтобы определять информацию о состоянии глаза и одновременно выводить информацию о состоянии глаза и информацию о наклоне волнового фронта глаза во время хирургической процедуры.2. Датчик волнового фронта по п. 1, в котором биометрические /анатомические измерения включают в себя одно или более из измерений осевого расстояния до глаза, глубины передней камеры, толщины роговицы, преломляющей оптической силы роговицы и преломляющей ...

CHANGES OF VISUAL ACUITY BY THERMAL MEANS

PHOTOCHEMICAL FABRIC CONNECTION

Apparatus and method for operating a real time large diopter range sequential wavefront sensor

An apparatus including a wavefront sensor including a light source (172) configured to illuminate a subject eye, a detector (122), an image sensor (162) configured to output an image of the subject eye, a first beam deflecting element (112) configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source (172) and configured to direct a portion of the wavefront from the subject eye through an aperture (118) toward the detector (122), and a controller coupled to the light source (172), the image sensor (162) and the beam deflecting element (112), configured to process the image to determine transverse movement of the subject eye and to control the beam deflecting element (112) to deflect and project through the aperture (118) portions of an annular ring portion of the wavefront and further configured to pulse the light source (172) at a firing rate to sample selected portions of the annular ring at the detector (122), to process ...

Epithelial ablation systems and methods

Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. Exemplary techniques include the administration of epithelial sequence ablation laser pulses and stromal sequence ablation laser pulses to the eye. A treatment laser generates a laser beam for ablation of eye tissue, and a movable scan component scans the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to treat the epithelial and stromal layers of the region.

Systems and methods for providing anatomical flap centration for an ophthalmic laser treatment system

Embodiments of this invention relate to systems and methods for providing anatomical flap centration for an ophthalmic laser treatment system. In one embodiment, the laser surgery system, having an imaging system and a suction ring coupled with a patient interface, captures a digital image of a subject's eye and identifies an optimum treatment placement of the corneal flap using anatomical markers as reference points.

System and method for laser corneal incisions for keratoplasty procedures

A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea.

METHODS AND SYSTEMS FOR LASER OPHTHALMIC SURGERY THAT PROVIDE FOR IRIS EXPOSURES BELOW A PREDETERMINED EXPOSURE LIMIT

A laser surgical method for performing a corneal incision while maintaining iris exposure below a predetermined exposure limit includes : determining an initial iris exposure based on an initial treatment scan, determining whether the initial iris exposure is less than the predetermined exposure limit; generating a revised treatment scan comprising one or more treatment scan modifying elements when the initial iris exposure is greater than the predetermined exposure limit, and scanning the focal zone of a pulsed laser beam according to the revised treatment scan, thereby performing the corneal incision, wherein the one or more treatment scan modifying elements causes the iris exposure to be smaller than the predetermined exposure limit.

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

A system for ophthalmic surgery includes a laser source configured to deliver an ultraviolet laser beam comprising laser pulses having a wavelength between 320 nm and 370 nm to photodecompose one or more intraocular targets within the eye with chromophore absorbance. The pulse energy, the pulse duration, and the focal spot are such that an irradiance at the focal spot is sufficient to photodecompose the one or more intraocular targets without exceeding a threshold of formation of a plasma and an associated cavitation event. An optical system operatively coupled to the laser source and configured to focus the ultraviolet laser beam to a focal spot and direct the focal spot in a pattern into the one or more intraocular targets. The optical system focuses the laser beam at a numerical aperture that provides for the focal spot to be scanned over a scan range of 6 mm to 10 mm.

THERMOKERATOPLASTY SYSTEM WITH A POWER SUPPLY THAT CAN DETERMINE A WET OR DRY CORNEA

APPARATUS AND METHOD FOR CREATING INCISIONS IN A HUMAN CORNEA

An apparatus for creating incisions in a human cornea comprises: a source of pulsed laser radiation; a scanner device for scanning the laser radiation; and a control computer for controlling the scanner device based on a control program, the control program containing instructions that, when executed by the computer, bring about the creation in the cornea of: a flap cut (42, 44) defining a corneal flap (40) that is connected to surrounding corneal tissue through a hinge; and one or more auxiliary cuts in connection with the flap cut for removing gas generated during creation of the flap cut, wherein the one or more auxiliary cuts define a first channel (52) extending from the flap cut to an anterior surface (46) of the cornea and a reservoir (54) located at least partially deeper within the cornea than the flap cut.

APPARATUS FOR CREATING INCISIONS IN A HUMAN CORNEA

An apparatus for creating incisions in a human cornea comprises: a source of pulsed laser radiation; a scanner device for scanning the laser radiation; and a control computer for controlling the scanner device based on a control program, the control program containing instructions that, when executed by the computer, bring about the creation in the cornea of: a flap cut defining a corneal flap that is connected to surrounding corneal tissue through a hinge; and one or more auxiliary cuts in connection with the flap cut for removing gas generated during creation of the flap cut, wherein the one or more auxiliary cuts define a first channel extending from the flap cut to an anterior surface of the cornea and a reservoir located at least partially deeper within the cornea than the flap cut.

PRESBYOPIA CORRECTION USING PATIENT DATA

... ²²²Methods, devices, and systems establish an optical surface shape that ²mitigates or treats presbyopia in a particular patient. The combination of ²distance vision and near vision in a patient can be improved, often based on ²input patient parameters such as pupil size, residual accommodation, and power ²need. Iterative optimization may generate a customized corrective optical ²shape for the patient.² ...

APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR

A wavefront sensor includes a light source (172) configured to illuminate a subject eye, a detector (122), a first beam deflecting element (112/412) configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source (172) and configured to direct a portion of the wavefront from the subject eye through an aperture (118/418) toward the detector (122) and a controller, coupled to the light source (172) and the first beam deflecting element (112/412), configured to control the first beam deflecting element (112/412) to deflect and project different portions of an annular ring portion (444/494) of the wavefront from the subject eye through the aperture (118/418) and further configured to pulse the light source (172) at a firing rate to sample selected portions of the annular ring (118/418) at the detector.

CROSS-LINKING OF EYE TISSUE

Abstract Disclosed are devices, systems and uses that involve a photosensitizer as well as nanoparticles, and a light source to activate the photosensitizer and/or the nanoparticles in order to cross-link corneal eye tissue. Selected embodiments employ a laser radiation source to create a channel in the eye tissue that is subsequently cross-linked. Date Recue/Date Received 2020-04-09 ...

SYSTEM AND METHOD FOR DEFINING AND CONTROLLING LTK AND OTHER SURGICAL EYE PROCEDURES TO PRODUCE LITTLE OR NO STROMAL COLLAGEN SHRINKAGE

One or more treatment parameters are determined for a cornea reshaping procedure. The one or more treatment parameters are selected so as to reduce an amount of collagen shrinkage in a cornea of a patient's eye (104) caused by the cornea reshaping procedure. For example, the one or more treatment parameters could be selected so as to minimize an amount of stromal collagen shrinkage in the cornea of the patient's eye caused by the cornea reshaping procedure. As another example, the cornea reshaping procedure could include irradiating multiple spots (350-352) on the cornea of the patient's eye, where each spot is associated with an amount of stromal collagen. The one or more treatment parameters could be selected so that no more than 1% or 5% of the stromal collagen in the irradiated spots undergoes clinically significant shrinkage as a result of the cornea reshaping procedure.

COLLAGEN TREATMENT APPARATUS

A method and apparatus for controlled thermal shrinkage of collagen tissue by irradiation with coherent energy in the wavelength band of 1.80 to 2.55 microns as generated by a laser. A specific application to ophthalmological corneal reshaping is described. A method for shrinkage of collagen tissue by application of coherent infrared energy in which the threshold shrinkage temperature is substantially reduced by application of a reagent such as lysozyme to the tissue prior to heating. The method is especially useful in ophthalmology for shape modification of a cornea, and is enhanced by using a corneal collagen shield as a carrier and delivery agent for the reagent and an admixed anaesthetic.

SYSTEM FOR SCANNING A SURGICAL LASER BEAM

In a laser beam delivery system for a surgical laser beam, steering and scanning of the laser beam along the target (20) in transverse (X and Y) directions is accomplished in a mechanically simple and fast-responding manner. Closely adjacent to the objective lens assembly (24) of the delivery system is a pair of prisms (12, 14), i:e. Risley prism Ar Herschel prism; positioned on the axis (16) of the approaching laser beam (18). The two prisms are mounted on separate rotating stages whereby they may be individually rotated about the beam axis. Co-rotation of the prisms produces circular scans, in diameters depending on the angle between the prisms. Counter rotation of the prisms at equal speeds will produce a diametric line scan. Any desired complex scan pattern can be achieved using combinations of rotations of the prisms. Axial compactness and proximity to the objective lens as- sembly assure that virtually all of the angularly emerging beam from the pri sm pair passes through the objective ...

For integration with glaucoma or cataract operation astigmatic operation method and device for

APPARATUS AND METHOD FOR PERFORMING LASER THERMAL KERATOPLASTY WITH MINIMIZED REGRESSION

L'invention concerne un appareil et un procédé pour effectuer une kératoplastie thermique par laser pour traiter des zones avec des formes permettant de réduire la régression. L'invention traite d'appareils et de procédés avec ou sans contact. Cet appareil comprend des sources de laser, un système optique de projection, un système d'observation et un système de commande. Dans certains modes de réalisation, le système de projection utilise deux miroirs de direction ou un masque pour contrôler la position du faisceau laser sur la cornée. Ce système de projection assure un contrôle précis de la zone de thermorétraction de la cornée à l'aide d'un laser à relativement faible puissance, comme des lasers à diodes. Les changements de puissance de réfraction de la cornée requis sont produits par des motifs sélectionnés de rétraction photothermique du tissu de collagène de la cornée. Les motifs sélectionnés sont des ensembles de formes allongées qui, de préférence, sont coniques au niveau des extrémités ...

METHOD AND APPARATUS FOR LASER SURGERY

Apparatus and method for laser surgery in which laser energy, pulsed or continuous, is focussed to a focus spot (FS) of a few microns which is located within tissue, or the like to cause highly localized heating. The pulsed radiation is in the TEM(oo) mode, has a wavelength of approximately 1064 nanometers, the pulses being not in excess of 100 nanoseconds and the pulse rate being approximately 2000 per second. Where the laser beam is continuous or pulsed, it has a wavelength of approximately 1400 to 1800 nanometers, or in photoablative modes, having a wavelength of 190 to about 300 nanometers. The focus spot (FS) may be caused to move relative to the axis of a handpiece (40) which delivers the laser energy to the body. Handpieces (20, 40) are provided in which laser energy is focussed to a focus spot (FS) of ten to thirty microns, and liquid is caused to flow across the exposure site to remove debris, a handpiece having a tubular terminal portion into which liquid is introduced, the distal ...

METHOD AND SYSTEM FOR LASER THERMOKERATOPLASTY

The invention is a system and method for modifying the corneal curvature by irradiating the cornea to deliver thermal energy to the stroma (134). The system includes multiple irradiation ports for introducing electromagnetic radiation; positioning means (42) such as a hemispherical dome (12) with several tracks (14) for positioning the irradiation ports, respectively, at locations of a pre-selected geometric pattern relative to the pretreated cornea, the geometric pattern being selected to correspond to a desired modified shape of the cornea; transmission means (76) adapted to deliver controlled amounts of the radiation to introduce the radiation to treatment volumes (140) of the stroma in a cooperative manner to induce desired shrinkage of the collagenous stromal tissue and cause change in the corneal curvature.

SYSTEM FOR AUTOMATICALLY DETECTING EYE CORNEAL STRIAE USING PROJECTED AND REFLECTED LIGHT

An automated eye corneal striae detection system (46) for use with a refractive laser system includes a cornea illuminator (60), a video camera interface (50), a computer (46), and a video display (62) for showing possible eye corneal striae to the surgeon. The computer includes an interface to control the corneal illuminator (48), a video frame grabber (52) that extracts images of the eye cornea from the video camera, and is programmed to detect and recognize eye corneal striae. The striae detection algorithm finds possible cornea striae, determines their location, or position, on the cornea and analyzes their shape. After all possible eye corneal striae are detected and analyzed, they are displayed for the surgeon on an external video display. The surgeon can then make a determination as to whether the corneal LASIK flap should be refloated, adjusted or smoothed again.

Method, implant, and apparatus for refractive keratoplasty

A method, implant, and apparatus to alter the refractive power of the cornea. The method involves creation of radial, intrastromal corneal incisions and insertion of semirigid, biocompatible implants (13). An apparatus (26) is provided to facilitate creation of the incisions with precise depth, orientation, and dimension. The implants (13) are of predetermined shape and curvature in accordance with the patient's pre-existing refractive error and corneal curvature. The implants (13) induce a predictable and stable flattening or steepening of corneal curvature for the correction of refractive errors. If residual refractive error is present following this procedure, the curvature or dimensions of the implants may be selectively increased or decreased by application of laser or other energy source to a heat-shrinkable portion of the implants, thereby eliminating residual refractive error.

Laser thermokeratoplasty methods and apparatus

Methods and apparatus for correction of optical defects in vision, employing an infrared radiation source and a focusing element, for changing the curvature of the eye by application of focused infrared radiation into the collagenous tissue of the cornea in a controlled manner.

Integrated surgical microscope and wavefront sensor

A wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated wavefront measurements of a patient's eye while the patient remains on an operating table in the surgical position. The device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap. The inclusion of lightweight, compact diffractive optical components in the wavefront sensor allows the integrated device to be supported on a balancing mechanism above a patient's head during a surgical procedure. As a result, the need to reposition the device and/or the patient between measuring optical properties of the eye and performing surgical procedures on the eye is eliminated. Many surgical procedures may be improved or enhanced using the integrated device, including but not limited to cataract surgery, Conductive Keratoplasty, Lasik surgery, and corneal corrective surgery.

Laser eye surgery lens fragmentation

A laser eye surgery system includes a laser to generate a laser beam. A spatial measurement system generates a measurement beam and measure a spatial disposition of an eye. A processor is coupled to the laser and the spatial measurement system, the processor comprising a tangible medium embodying instructions to determine a spatial model of the eye in an eye coordinate reference system based on the measurement beam. The spatial model is mapped from the eye coordinate reference system to a machine coordinate reference system. A laser fragmentation pattern is determined based on a plurality of laser fragmentation parameters. The laser fragmentation pattern and the spatial model is rotated by a first rotation angle such that the spatial model is aligned with the reference axis of the machine coordinate reference system and the rotated laser fragmentation pattern is aligned with the corneal incision.

КРОССЛИНКИНГ ТКАНЕЙ ГЛАЗНОГО ЯБЛОКА

FIELD: medicine. SUBSTANCE: group of inventions relates to medicine. Device for cross-linking the tissues of the eyeball comprises: instrument for introducing a photosensitizer and nanoparticles into eyeball tissue, and a laser radiation source configured to emit radiation which is intended for simultaneous activation of each of the photosensitizer and nanoparticles, wherein the laser radiation source also comprises one or more of a second harmonic generation crystal and a third harmonic generation crystal for generating radiation intended to create a channel through the epithelial layer of eyeball tissues; system for directing and focusing laser radiation in relation to eyeball tissues and computer for controlling the system. At that, the computer is programmed to control laser radiation so that: create at least a channel through a layer of epithelium of eyeball tissues; cause instrumentation of photosensitizer and nanoparticles into canal through epithelial layer of eyeball tissues and simultaneously activate each of photosensitizer and nanoparticles, wherein the photosensitizer being activated provides cross-linking in eyeball tissues. Nanoparticles, when activated, catalyze cross-linking by means of a photosensitizer. EFFECT: use of this group of inventions will make it possible to strengthen corneal stability. 7 cl, 4 dwg, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 703 703 C2 (51) МПК A61F 9/008 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61F 9/0008 (2019.05); A61F 9/008 (2019.05); A61N 5/062 (2019.05) (21)(22) Заявка: 2015135997, 25.08.2015 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): УЭЙВЛАЙТ ГМБХ (DE) Дата регистрации: 21.10.2019 Приоритет(ы): (30) Конвенционный приоритет: 26.08.2014 DE 102014012675.7 (43) Дата публикации заявки: 02.03.2017 Бюл. № 7 (45) Опубликовано: 21.10.2019 Бюл. № 30 2 7 0 3 7 0 3 R U (54) КРОССЛИНКИНГ ТКАНЕЙ ГЛАЗНОГО ЯБЛОКА (57) Реферат: ...

Aberration control by corneal collagen crosslinking combined with beam-shaping technique

Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A scanning laser or the like is used to perform the corneal collagen crosslinking by locally altering the optical path length (thickness, refractive index, or both).

Photochemical tissue bonding

Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair.

Conformable Therapeutic Shield for Vision and Pain

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

Eye Therapy System

Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

Ophthalmological apparatus for the breakdown of eye tissue

An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system.

Anti-Astigmatic Keratotomy

The invention relates to an ophthalmological instrument for carrying out a laser-surgical intervention on the eye (), comprising a femtosecond laser (), which emits pulsed laser radiation (), an objective (), from which the laser radiation () emerges in a focused manner in the direction of the eye (), at least one deflection device (), which deflects the laser radiation () and which varies the focal position within the cornea () of the eye (), and a program-controlled control device (), which is connected to the deflection device () and configured to generate a predetermined cut profile within the cornea (), wherein the cut profile comprises at least one arcuate incision () in the periphery of the cornea (). It is an object of the invention to provide an improved ophthalmological instrument for anti-astigmatic keratotomy with the femtosecond laser (). This object is achieved by the invention by virtue of the program-controlled control device () being furthermore configured to vary the cut depth (D) along the arcuate incision (), the cut depth (D) reducing toward the ends of the arc. Moreover, the invention relates to a computer program for controlling an ophthalmological instrument. 141232462548659589. An ophthalmological instrument for carrying out a laser-surgical intervention on the eye () , comprising a femtosecond laser () , which emits pulsed laser radiation () , an objective () , from which the laser radiation () emerges in a focused manner in the direction of the eye () , at least one deflection device () , which deflects the laser radiation () and which varies the focal position within the cornea () of the eye () , and a program-controlled control device () , which is connected to the deflection device () and configured to generate a predetermined cut profile within the cornea () , wherein the cut profile comprises at least one arcuate incision () in the periphery of the cornea () , wherein the program-controlled device () is furthermore configured to vary ...

RETINAL IMAGING FOR REFERENCE DURING LASER EYE SURGERY

A method of laser eye surgery including linking retinal vessel architecture to corneal topography. This enables registration of the steep axis of the cornea in order to orient a toric intraocular lens, and/or to place astigmatic keratotomy incisions. First, a detailed pre-operative retinal image of the vasculature of the retina is obtained. In addition, a pre-operative image of the topography of the eye is obtained. The retinal image is then correlated or superimposed on the topography image to provide a reference. After the patient lies down under the laser eye surgery system, and during the surgery, the retinal vasculature is monitored which provides a reference to the surgery system about the topography of the eye. This process enables registration of the steep axis of the cornea in order to orient a toric intraocular lens and/or to place astigmatic keratotomy incisions. 1. A method of eye surgery on an astigmatic patient , comprising:pre-operatively obtaining a first retinal image of the retinal vessel architecture or optic nerve;pre-operatively scanning the corneal topography of the patient to obtain a scan;correlating the first retinal image and scan to determine retinal landmarks associated with an astigmatic axis of the patient;recording the location of the retinal landmarks in an optical system of an eye surgery system used for the eye surgery;positioning the patient supine on a chair configured for the eye surgery;obtaining a second retinal image of the retinal vessel architecture or optic nerve while the patient is positioned on the chair;analyzing the second retinal image to gauge a misalignment of the eye compared to the first retinal image;adjusting the patient or eye surgery system based on the misalignment and correlation of the first and second retinal images and scan; andperforming an eye surgery.2. The method of claim 1 , wherein the eye surgery is insertion of a toric intraocular lens claim 1 , and the step of recording includes placing a reticle ...

CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. 1. A covering to treat an eye of a patient , wherein ,the eye comprises a cornea, an ablated stroma, and an epithelium, wherein the epithelium comprises an inner portion comprising irregularities characterized by an irregularity profile and an outer portion;the covering comprises a conformable inner portion comprising an upper surface profile;the covering comprises an outer portion configured to adhere to the outer portion of the epithelium; andthe upper surface profile corresponds to a profile of the ablated stroma and is configured to smooth the irregularities when the outer portion of the covering adheres to the outer portion of the epithelium.2. The covering of claim 1 , wherein claim 1 ,the irregularity profile comprises spatial frequencies;the upper surface profile comprises spatial frequencies; andthe upper surface profile spatial frequencies are lower than the spatial frequencies of the irregularity profile.3. The covering of claim 1 , wherein the conformable inner portion comprises a stretchable material configured to stretch across the irregularities of the epithelium and to smooth the irregularities transferred from the irregularity ...

Method of altering the refractive properties of an eye

The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.

Method for controlling an eye surgical laser and treatment apparatus

A method for controlling a surgical laser for the separation of a volume body, with predefined posterior and anterior interfaces, from a human or animal cornea is disclosed. The method including controlling the laser by means of a control device such that it emits pulsed laser pulses in a shot sequence into the cornea. The interfaces are generated by the generation of a plurality of cavitation bubbles generated by photodisruption by means of an interaction of the individual laser pulses with the cornea. A minimum diameter of the volume body orthogonal to an optical axis of the volume body is determined depending on at least one diopter value for the volume body and on a preset thickness of the volume body viewed in a direction of the optical axis. A treatment apparatus, a computer program product and a computer-readable storage medium are also disclosed.

Method and system for modifying eye tissue and intraocular lenses

A system for ophthalmic surgery includes a laser source configured to deliver an ultraviolet laser beam comprising laser pulses having a wavelength between 320 nm and 370 nm to photodecompose one or more intraocular targets within the eye with chromophore absorbance. The pulse energy, the pulse duration, and the focal spot are such that an irradiance at the focal spot is sufficient to photodecompose the one or more intraocular targets without exceeding a threshold of formation of a plasma and an associated cavitation event. An optical system operatively coupled to the laser source and configured to focus the ultraviolet laser beam to a focal spot and direct the focal spot in a pattern into the one or more intraocular targets. The optical system focuses the laser beam at a numerical aperture that provides for the focal spot to be scanned over a scan range of 6 mm to 10 mm.

SYSTEM AND METHOD FOR LASER CORNEAL INCISIONS FOR KERATOPLASTY PROCEDURES

A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea. 1. A method of treating a cornea of an eye , the method comprising:measuring a profile of a posterior portion of the cornea;incising the cornea with a beam pulse profile based on the profile of the posterior portion.2. The method of claim 1 , wherein the cornea is treated so as to inhibit light scatter at a treated posterior surface of the treated cornea.3. The method of claim 1 , further comprising:measuring folds of the posterior portion of the cornea, wherein the beam pulse profile extends along the posterior portion in response to the folds to inhibit transecting lamella of the stroma.4. The method of claim 1 , wherein the posterior portion comprises an irregular posterior surface claim 1 , and wherein the beam pulse profile provides an irregular incision profile corresponding to the irregular posterior surface.5. A method as in claim 4 , wherein the irregular posterior surface corresponds to folds of stromal lamella of the cornea and wherein the irregular incision profile decreases transaction of the stromal lamella.6. The method of claim 5 , wherein a donor cornea comprises an irregular donor posterior surface corresponding to donor folds of donor stromal lamella of the donor cornea and wherein an irregular donor incision profile corresponding to the donor folds of the donor stromal lamella decreases transaction of the donor stromal lamella.7. The method of claim 1 , wherein the profile corresponds to folds of a Descemet's membrane of the cornea and wherein the incision profile ...

CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. 1. A covering for an eye of a patient , the eye comprising a cornea , an epithelial defect , and an epithelium , the covering comprising:an inner portion, wherein the inner portion comprises silicone and is characterized by a center thickness from 50 μm to 250 μm, an oxygen permeability Dk of at least 450; andan outer portion coupled to the inner portion;wherein, when applied to an eye of a patient, the outer portion of the covering at least partially conforms to the cornea,wherein the inner portion provides a chamber between a posterior surface of the inner portion and the cornea in a region of the epithelial defect, andwherein the outer portion is configured so as to resist movement of the inner portion with the outer portion is placed on the eye.2. The covering of claim 1 , wherein the epithelial defect comprises an ablated stroma.3. The covering of claim 1 , wherein the chamber provides an environment configured to promote growth of the epithelium extending over the epithelial defect of at least about 6 mm across within about 2 days of a photorefractive keratectomy (PRK) ablation.4. The covering of claim 1 , wherein the inner portion has an ...

TECHNIQUE FOR LASER-CUTTING AN ENDOTHELIAL CORNEAL GRAFT

A method for preparing an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea from an endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving the focal point of the radiation to form an endothelial graft in the donor cornea. By irradiating the donor cornea from the endothelial side thereof, instead of the epithelial side, to cut the endothelial graft, optical inhomogeneities which may develop after death in stromal tissue of the donor cornea leave the laser cutting process substantially unaffected. 1. A method of preparing an endothelial corneal graft using laser radiation , the method comprising:providing a donor cornea isolated from a dead body;irradiating the donor cornea from the endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; andmoving the focal point of the radiation to form an endothelial graft in the donor cornea.2. The method of claim 1 , wherein providing the donor cornea includes deforming the donor cornea to have a curvature opposite to a natural curvature of the donor cornea.3. The method of claim 1 , wherein providing the donor cornea includes placing an endothelium of the donor cornea in contact with a reference contact surface of a laser apparatus generating the laser radiation.4. The method of claim 3 , comprising:determining a thickness of a predetermined structure of the donor cornea, the predetermined structure formed by one of an endothelium, a Descemet membrane and a Dua layer of the donor cornea or a combination thereof;based on the determined thickness of the predetermined structure, determining a desired thickness of the endothelial graft;wherein moving the focal point of the radiation includes moving the focal point across a surface that is a distance corresponding to the desired thickness of the ...

OPHTHALMOLOGICAL DEVICE AND METHOD FOR THE TREATMENT OF CORNEAL DISEASES

An ophthalmological device () for the treatment of corneal diseases such as keratoconus and glaucoma, comprises a moulding head (), a suction body () and a UV lamp (). The moulding head () has a hollow cylindrical configuration and includes a rigid moulding lens () for shaping the cornea of an eye () of a patient. The lens is curved and defines a plurality of apertures therein. The suction body () has a hollow cylindrical configuration. The lamp () is fitted to the suction body. Moulding head () and suction body () together define a chamber () from which air is evacuated so as to induce a partial vacuum within the chamber () for attracting the cornea onto the lens (). A photo-sensitizer is applied to the eye and while the cornea is held against the mould, it is irradiated with UV light by lamp () so as to cross-link collagen fibres in the cornea. 1. An ophthalmological device for the treatment of corneal diseases , which includes:a mould having a curved, transparent moulding surface defining a plurality of apertures therein, which is applied to the coma of an eye of a patient for shaping the corneal tissue to a desired curvature;a suction body defining a suction chamber in which a partial vacuum is induced so as to form a partial vacuum within the mould which attracts the cornea onto the moulding surface; anda radiation source for irradiating the cornea with a beam of radiation.2. The ophthalmological device as claimed in claim 1 , wherein the mould includes a rigid lens winch defines said curved moulding surface claim 1 , the moulding surface of the lens having a predetermined curvature so as to shape the corneal tissue to said desired curvature.3. The ophthalmological device as claimed in claim 2 , wherein the mould lens is in the form of a rigid contact lens.4. The ophthalmological device as claimed in claim 3 , wherein the mould is removably connected to the suction body claim 3 , thereby permitting the mould to be removed and replaced by another mould with a ...

Devices and Methods for Novel Retinal Irradiance Distribution Modification to Improve and Restore Vision without Producing Corneal Vitrification

Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.

LASER THERMAL CONJUNCTIVOPLASTY

Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe. 1. A handheld laser probe for laser thermal conjunctivoplasty , comprising:a pair of forceps;a laser delivery fiber to deliver the laser light to the probe; anda cylindrical lens to focus a laser beam into a line,wherein the forceps are configured to grasp a conjunctival fold and, and the line-focused laser beam is configured to uniformly heat the conjunctival fold.2. The handheld laser probe of claim 1 , wherein the forceps have angled long tissue platforms.3. The handheld laser probe of claim 1 , wherein the cylindrical lens focuses laser light into a line with a length of about 10 mm and a width of about 1 mm.4. A system for laser thermal conjunctivoplasty claim 1 , comprising: a pair of forceps; and', 'a line focused laser beam coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps;, 'a handheld laser probe configured for laser thermal conjunctivoplasty, comprisinga laser light source coupled to the handheld laser probe; anda control system coupled to the laser.5. The system of claim 4 , wherein the line focused laser beam comprises a pulse laser beam.6. The system of claim 4 , wherein the handheld laser probe is coupled to the laser by a multimode optical fiber.7. The system of claim 4 , wherein the control system comprises a foot pedal.8. The ...

APPARATUS AND METHODS FOR PERFORMING ENHANCED VISUALLY DIRECTED PROCEDURES UNDER LOW AMBIENT LIGHT CONDITIONS

A system, method, and apparatus for performing enhanced visually directed procedures under low ambient light conditions are disclosed. An example method includes acquiring at least one real-time high resolution video signal representing at least one view of an eye in at least one wavelength of light outside of the wavelengths of visible light. The example method also includes converting the at least one view corresponding to the at least one real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light into at least one wavelength of visible light. The at least one real-time high resolution video signal is acquired after light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter. 1. A method for performing an enhanced visually directed procedure under low ambient visible light on a patient's eye , the method comprising:acquiring, from at least one high resolution photosensor, at least one real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light;converting, via a processor, the at least one view corresponding to the at least one real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light into at least one wavelength of visible light;displaying, via the processor, the at least one view corresponding to the at least one real-time high resolution video signal including the at least one wavelength of visible light;wherein the processor causes the at least one high resolution photosensor to acquire the at least one real-time high resolution video signal after light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter.2. The method of claim 1 , further comprising:inspecting the eye of the patient; ...

EPITHELIAL ABLATION SYSTEMS AND METHODS

Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. Exemplary techniques include the administration of epithelial sequence ablation laser pulses and stromal sequence ablation laser pulses to the eye. A treatment laser generates a laser beam for ablation of eye tissue, and a movable scan component scans the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to treat the epithelial and stromal layers of the region. 1. A method for treating a region of a cornea of an eye using a laser , the region of the cornea including an epithelial layer and a stromal layer , the method comprising:receiving an epithelial thickness map corresponding to the eye;receiving an epithelial basis data corresponding to an epithelial laser pulse ablation profile;ablating the epithelial layer with a first epithelial arrangement of laser beam pulses based on the epithelial thickness map and the epithelial basis data;receiving a crossover signal; andterminating the first epithelial arrangement of laser beam pulses in response to the crossover signal.2. The method of claim 1 , further comprising:receiving second epithelial basis data corresponding to a second epithelial laser pulse ablation profile;after terminating the first epithelial arrangement of laser beam pulses, ablating the epithelial layer with a second epithelial arrangement of laser beam pulses based on the epithelial thickness map and the second epithelial basis data.3. The method of claim 2 , wherein ablating the epithelial layer with the second epithelial arrangement of laser beam pulses is performed in response to inputs received from a human operator.4. The method of claim 2 , wherein the first epithelial arrangement of laser beam pulses has a first laser beam pulse repetition rate and the second epithelial arrangement of laser beam pulses has ...

METHODS FOR CROSS-LINKING CORNEAL COLLAGEN WITH VERTEPORFIN FOR THE TREATMENT OF DISORDERS OF THE EYE

Described are compositions and methods of using verteporfin-based photodynamic therapy (PDT) to increase the biomechanical strength of the cornea. More particularly, described herein are compositions and methods for cross-linking collagen in corneal tissue which are useful in the treatment of corneal ectatic disorders. 1. A method for increasing corneal rigidity in a subject , comprisingtopically administering an effective amount of a composition comprising verteporfin to the cornea of a subject in need thereof; andirradiating the cornea with non-thermal laser light.2. The method of claim 1 , wherein the subject has undergone claim 1 , or is going to undergo claim 1 , a refractive surgical procedure.3. The method of claim 2 , wherein the refractive surgical procedure is radial keratotomy (RK) claim 2 , photorefractive keratectomy (PRK) claim 2 , or laser in-situ keratomileusis (LASIK).4. The method of claim 1 , wherein the verteporfin composition is a lotion claim 1 , gel claim 1 , cream claim 1 , ointment claim 1 , solution claim 1 , spray claim 1 , paste or aerosol composition.5. The method of claim 1 , wherein topically administering a composition comprising verteporfin comprises soaking the cornea with a verteporfin solution.6. The method of claim 1 , further comprising monitoring the amount of collagen cross-linking in the cornea.7. The method of claim 1 , wherein the verteporfin composition comprises 1.0 claim 1 , 1.5 claim 1 , 2.0 claim 1 , 2.5 claim 1 , 3.0 claim 1 , 3.5 claim 1 , 4.0 claim 1 , 4.5 claim 1 , 5.0 claim 1 , 5.5 claim 1 , 6.0 claim 1 , 6.5 claim 1 , 7.0 claim 1 , 7.5 claim 1 , 8.0 claim 1 , 8.5 claim 1 , 9.0 claim 1 , 9.5 claim 1 , or 10.0 mg/ml of verteporfin.8. The method of claim 1 , wherein irradiating the corneal with non-thermal laser light promotes cross-linking of collagen in the cornea.9. The method of claim 1 , wherein irradiating the corneal with non-thermal laser light is performed for a time sufficient to induce cross-linking of ...

Cross-linking of eye tissue

The present disclosure relates to the cross-linking of eye tissue. Embodiments of the disclosure relate to the activation of a photosensitizer and/or nanoparticles for the cross-linking of eye tissue.

OPHTHALMOLOGICAL APPARATUS FOR THE BREAKDOWN OF EYE TISSUE

An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system. 1. An ophthalmological apparatus , comprising:a light source, and fastening means configured to fix the appliance on the eye,', 'a light projector, optically connected to the light source, for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue, and having a projection axis,', 'a movement driver configured to mechanically move the light projector and its projection axis with the appliance being fixed on the eye, to move the focal point of the punctiform tissue breakdown and thereby produce cuts by moving said focal point., 'an appliance for manual application onto an eye, the application comprising2. The ophthalmological apparatus according to claim 1 , wherein the movement driver and the light projector are set up and coupled such that the light projector is movable into a position in which at least a portion of the eye can be examined in top view upon fixing the appliance on the eye.3. The ophthalmological apparatus according to claim 1 , wherein the movement driver and the light projector are set up and coupled such that the light projector can be moved equidistantly from a movement surface.4. The ...

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

As shown in the drawings for purposes of illustration, a method and system for making physical modifications to intraocular targets is disclosed. In varying embodiments, the method and system disclosed herein provide many advantages over the current standard of care. Specifically, linear absorption facilitated photodecomposition and linear absorption facilitated plasma generation to modify intraocular tissues and synthetic intraocular lenses. 110-. (canceled)11. A system for ophthalmic surgery , the system comprising:a laser system comprising an optical system and a laser source configured to deliver a laser beam to intraocular targets and for physically modifying at least one of the intraocular targets; the laser beam comprising a plurality of laser pulses having a pulse energy, a pulse duration between 1 picosecond and 100 nanoseconds, and a wavelength between about 320 nanometers and about 430 nanometers; the optical system being operatively coupled to the laser source and configured to focus the laser beam to a focal spot and scan the focal spot within the intraocular targets, wherein:confocal reflectometry is used to determine locations and shapes of the intraocular targets.12. The system of claim 11 , wherein the pulse energy claim 11 , the pulse duration claim 11 , and the focal spot are configured such that the laser beam irradiance at the focal spot is sufficiently high to physically modify the at least one of the intraocular targets by photodecomposition but not exceeding a threshold of formation of a plasma and associated cavitation event.13. The system of or claim 11 , wherein the wavelength is between 320 nanometers and 400 nanometers.14. The system of any of the preceding claims claim 11 , wherein the wavelength is about 355 nanometers.15. The system of any of the preceding claims claim 11 , wherein the pulse duration is about 400 picoseconds.16. The system of any of the preceding claims claim 11 , wherein the pulse energy is between 0.01 microJoules ...

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

As shown in the drawings for purposes of illustration, a method and system for making physical modifications to intraocular targets is disclosed. In varying embodiments, the method and system disclosed herein provide many advantages over the current standard of care. Specifically, linear absorption facilitated photodecomposition and linear absorption facilitated plasma generation to modify intraocular tissues and synthetic intraocular lenses. 110-. (canceled)11. A system for ophthalmic surgery , the system comprising:a laser system comprising an optical system and a laser source configured to deliver a laser beam to intraocular targets for measuring locations and shapes of the intraocular targets and for physically modifying at least one of the intraocular targets; the laser beam comprising a plurality of laser pulses having a pulse energy, a pulse duration between 1 picosecond and 100 nanoseconds, and a wavelength between about 320 nanometers and about 430 nanometers; the optical system being operatively coupled to the laser source and configured to focus the laser beam to a focal spot and scan the focal spot within the intraocular targets;control electronics configured to operate the laser system to generate a treatment pattern for physically modifying the at least one of the intraocular targets, based on measuring information from the laser beam.12. The system of claim 11 , wherein the pulse energy claim 11 , the pulse duration claim 11 , and the focal spot are configured such that the laser beam irradiance at the focal spot is sufficiently high to physically modify the at least one of the intraocular targets by photodecomposition but not exceeding a threshold of formation of a plasma and associated cavitation event.13. The system of or claim 11 , wherein the wavelength is between 320 nanometers and 400 nanometers.14. The system of any of the preceding claims claim 11 , wherein the wavelength is about 355 nanometers.15. The system of any of the preceding claims ...

CORNEAL TOPOGRAPHY MEASUREMENT AND ALIGNMENT OF CORNEAL SURGICAL PROCEDURES

Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye. 115-. (canceled)16. An apparatus for treating an eye having a cornea , the apparatus comprising:a topography measurement system for measuring a topography of the cornea of the eye; a patient interface for coupling to and retaining the eye; and', 'a processor comprising a tangible medium configured to determine a position of the eye, wherein the processor comprising the tangible medium is configured to determine one or more of a position or an orientation of the eye in response to the first image and the second image when the patient interface has been paced over the cornea., 'an image capture device for capturing an image of the eye, the image capture device configured to capture the first image of the eye when the cornea is exposed to a gas and a second image of the eye with the patient interface over the cornea;'}17. The apparatus of claim 16 , wherein the topography measurement system comprises one or more of a keratometry system claim 16 , an optical coherence tomography system claim 16 , a Placido disc topography system claim 16 , a Hartmann-Shack topography system claim 16 , a Scheimpflug image topography system claim 16 , a confocal tomography system claim 16 , or a low coherence reflectometry system.18. The apparatus of claim 16 , ...

Laser therapy system and method for treatment of a collagen structure and of varicose blood vessels in an eye

The present invention refers to a Laser therapy system and a method for treatment of a sclera/conjunctiva of an eye, comprising: a dispenser for a photosensitizer agent; a 3D imaging unit; an image processing unit being adapted to recognize the collagen tissue structure and to determine a thickness thereof; a UVA light source being adapted to a crosslinking of the collagen tissue; a second Laser light source being adapted to be absorbed mainly by varicose blood vessels; an optical system for deflecting and focusing the UVA light and the second Laser light on a focus point within the sclera/conjunctiva; a processing and control unit being adapted to determine a target thickness and a thickness deviation; a pattern for an application of the UVA light energy; a UVA light energy to effect a growth of the collagen tissue structure until the target thickness is achieved.

CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. 1. A covering to treat an eye of a patient , wherein ,the eye comprises a cornea, an ablated stroma, and an epithelium, wherein the epithelium comprises an inner portion comprising irregularities characterized by an irregularity profile and an outer portion;the covering comprises a conformable inner portion comprising an upper surface profile;the covering comprises an outer portion configured to adhere to the outer portion of the epithelium; andthe upper surface profile corresponds to a profile of the ablated stroma and is configured to smooth the irregularities when the outer portion of the covering adheres to the outer portion of the epithelium.2. The covering of claim 1 , wherein claim 1 ,the irregularity profile comprises spatial frequencies;the upper surface profile comprises spatial frequencies; andthe upper surface profile spatial frequencies are lower than the spatial frequencies of the irregularity profile.3. The covering of claim 1 , wherein the conformable inner portion comprises a stretchable material configured to stretch across the irregularities of the epithelium and to smooth the irregularities transferred from the irregularity ...

Devices and Methods for Novel Retinal Irradiance Distribution Modification to Improve and Restore Vision without Producing Corneal Vitrification

Methods and apparatus to improve or restore vision by causing a rebooting of the visual system of an eye with modification of visual search, sampling and stimulation away from the preferred retinal locus of fixation of an eye to enhance neural integration and perception of visual information from within the field of view are described herein. Some embodiments cause transient, reversible or repeatable redirection of environmental light away from the preferred retinal locus of fixation of an eye to multiple retinal locations that are not the preferred retinal locus of fixation. Some embodiments reduce exposure of environmental light at the preferred retinal locus of fixation of an eye for a determinable interval at a determinable rate. Some embodiments cause a defocusing of environmental light at the preferred retinal locus of fixation in an eye with a visual impairment or loss. 1. An apparatus for improving or restoring vision , the apparatus comprising:one or more clear components positioned anterior to a retina of an eye;one or more transformable components disposed on a surface of, or within, the one or more clear components; anda controller coupled to the one or more transformable components via a conductive component, the controller being configured to generate and route control signals to the one or more transformable components,wherein, upon receipt of the control signals, the one or more transformable components reorganize at least one pattern of a direction of environmental light from within a field of view of the eye to the retina at a determinable rate up to 50 kilohertz, andwherein the at least one pattern causes a defocusing at the preferred retinal locus of fixation of the eye and wherein the at least one pattern does not generate an aperture.2. The apparatus of claim 1 , wherein the at least one pattern of direction of environmental light to the retina causes a focusing at a plurality of non-contiguous retinal locations that are not the preferred ...

ENHANCED VISUALLY DIRECTED PROCEDURES UNDER LOW AMBIENT LIGHT CONDITIONS

Performance of enhanced visually directed procedures under low ambient lighting conditions. A computer readable medium storing a set of computer instructions for performing an enhanced visually directed procedure under low ambient visible light on a patient's eye. The computer instructions include: acquiring at least one real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light. The computer instructions include converting the at least one view is converted corresponding to the at least one real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light into at least one wavelength of visible light. The at least one high resolution photosensor is acquired after light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter. 1. A method for performing an enhanced visually directed procedure under low ambient visible light on a patient's eye , comprising:acquiring, from a first high resolution photosensor, at least one first real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light;acquiring, from a second high resolution photosensor, at least one second real-time high resolution video signal representing the at least one view of the eye in visible light;acquiring the at least one first real-time high resolution video signal and the at least one second real-time high resolution video signal after light conditions are low enough such that an intensity of the light conditions is below a predetermined threshold of patient discomfort;converting, via a processor, the at least one view corresponding to the at least one first real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light ...

METHODS FOR PREVENTING OR TREATING POSTERIOR CAPSULAR OPACIFICATION

The present invention relates to methods and apparatus for preventing or treating posterior capsular opacification in a subject in need of prophylaxis or treatment for posterior capsular opacification, including a subject undergoing cataract surgery by ablating epithelial cells on an interior surface of the lens capsule with a multi-photon laser system. 1. A method for preventing or treating posterior capsular opacification in a subject in need of prophylaxis or treatment of posterior capsular opacification , wherein the subject has a lens capsule having an anterior portion and a posterior portion , and each of the anterior and posterior portions has an exterior surface and an interior surface , the method comprising:imaging epithelial cells on one or more interior surfaces of the lens capsule using an imaging technique selected from the group consisting of confocal microscopy, adaptive optics, ultrasound, detecting a chemical agent and/or a biological agent, multi-photon laser imaging, and combinations thereof; andablating the imaged epithelial cells.2. The method of claim 1 , wherein a laser is used for imaging the epithelial cells claim 1 , and the same laser used for imaging is used for ablating the epithelial cells.3. The method of claim 1 , wherein the ablation system comprises a femtosecond laser as the laser source.4. The method of claim 1 , wherein the epithelial cells are ablated without damaging or breaking the lens capsule.5. The method of claim 1 , wherein the method further comprises removing a cataractous lens from the subject while retaining the lens capsule claim 1 , and inserting an artificial intraocular lens; and either before and/or after the inserting step claim 1 , imaging and ablating the epithelial cells one or both of the interior surfaces of the lens capsule.6. The method of claim 5 , wherein the epithelial cells are imaged at the interior surface of the anterior portion of the lens capsule before the inserting step.7. The method of claim ...

System for performing eye surgery with simultaneous display of graphical information for flap and ablation

The disclosure relates to systems and methods for performing eye surgery in which a single image that simultaneously presents a graphical representation of a planned or actual flap location superimposed with a graphical representation of a planned or actual area of ablation is used.

SYSTEM AND METHOD FOR MEASURING AND CORRECTING ASTIGMATISM USING LASER GENERATED CORNEAL INCISIONS

A laser system that includes a laser source emitting a laser beam along an axis and a keratometer. The keratometer includes a first set of individual light sources that are equally spaced from one another along a first ring and that direct a first light toward an eye and a second set of individual light sources that are equally spaced from another along a second ring and direct a second light toward the eye, wherein the first ring and said second ring are co-planar and concentric with one another about the axis. The laser system includes a telecentric lens that receives the first light and second light reflected off of the eye and a detector that receives light from the telecentric lens and forms an image. The laser system also includes a processor that receives signals from said detector representative of the image and determines an astigmatism axis of the eye based on the signals. 1. A laser system comprising:a laser source emitting a laser beam along an axis; a first set of individual light sources that are equally spaced from one another along a first ring and that direct a first light toward an eye;', 'a second set of individual light sources that are equally spaced from another along a second ring and direct a second light toward said eye, wherein said first ring and said second ring are co-planar and concentric with one another about said axis;', 'a telecentric lens that receives said first light and second light reflected off of said eye;', 'a detector that receives light from said telecentric lens and forms an image;', 'a processor that receives signals from said detector representative of said image and determines an astigmatism axis of said eye based on said signals., 'a keratometer comprising2. The laser system of claim 1 , wherein said processor determines a corneal K value and orientation of said astigmatism axis based on said signals.3. The laser system of claim 1 , wherein said keratometer is structured so as to reduce systematic errors in use of ...

LASER PULSE MODULATION FOR LASER CORNEAL TREATMENTS

Laser pulse modulation for laser corneal treatments is used to control the thermal energy imparted to the cornea. The optical energy of the laser pulses may be modulated to reduce or increase the thermal energy, depending upon an expected thermal load or a measured temperature at each position location of the cornea subject to laser treatment. The laser pulse modulation may involve pulse frequency modulation, pulse amplitude modulation, and pulse duration modulation. 1. A method for laser pulse modulation for corneal laser treatments , the method comprising:accessing a surgical plan for a corneal laser treatment of a cornea of a patient, wherein the surgical plan specifies position locations on the cornea for the corneal laser treatment and a number of laser pulses for each of the position locations; andperforming the corneal laser treatment according to the surgical plan, wherein a thermal energy imparted to a first position location on the cornea by the laser pulses is controlled by modulating an optical energy of the laser pulses at the first position location to control a temperature of the cornea.2. The method of claim 1 , wherein modulating the optical energy further comprises:modulating a frequency of the laser pulses.3. The method of claim 1 , wherein modulating the optical energy further comprises:modulating at least one of an amplitude and a duty cycle of the laser pulses.4. The method of claim 1 , wherein modulating the optical energy further comprises:linearly reducing the optical energy of the laser pulses at the first position location from a rated value of a laser source used for the corneal laser treatment to a second value lower than the rated value over a duration, wherein the second value and the duration are predetermined to limit the thermal energy to prevent the temperature of the cornea at the first position location from exceeding a threshold temperature.5. The method of claim 1 , wherein modulating the optical energy further comprises: ...

OPHTHALMOLOGICAL LASER THERAPY DEVICE

An ophthalmological laser therapy device including a laser system, an x-y scanner, collecting optics and a z-scanner. The invention also relates to a method for processing a tissue of an eye by a therapeutic laser beam of an ophthalmological laser therapy device. The invention provides an ophthalmological laser therapy device and a corresponding method which permit, with minimal engineering complexity, a very quick positioning of the laser spot in a large volume region, in particular in a large x-y region perpendicular to the optical axis. The problem is also solved by a method for processing a tissue of the eye or a material located in an eye using an ophthalmological laser therapy device, wherein each sub-section of the tissue of the eye is processed using a corresponding positioning or the device for the adjustable redirecting of the laser beam in an image field of the collection optics. 116-. (canceled)17. An ophthalmological laser therapy device having an optical axis that includes a laser system that generates a therapy laser beam and , in a beam path of the therapy laser beam , comprises:an x-y scanning unit configured to deflect the therapy laser beam perpendicular to the optical axis;a collecting optics, comprising one or more lens elements, and having an axis of symmetry, which is identical to the optical axis, configured for mapping the therapy laser beam in an image field;a z scanning device that shifts the focal point of the therapy laser beam in a z direction along the optical axis; andan adjustable laser beam deflection device, which is disposed in the beam path of the therapy laser beam downstream of the x-y scanning unit, the z a scanning device and the collecting optics.18. The ophthalmological laser therapy device according to claim 17 , in which the adjustable laser beam deflection device comprises a partial or fully reflective surface and two axes that are perpendicular to one another claim 17 , wherein the partial or fully reflective surface ...

Femtosecond laser system and methods for photorefractive keratectomy

Embodiments of this invention generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incision. In an embodiment, an ophthalmic surgical laser system comprises a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, an XY-scan device to deflect the pulsed laser beam, a Z-scan device to modify a depth of a focus of the pulsed laser beam, and a controller configured to form a top lenticular incision and a bottom lenticular incision of a lens in the subject's eye, or just a bottom lenticular incision.

CORNEAL TOPOGRAPHY MEASUREMENTS AND FIDUCIAL MARK INCISIONS IN LASER SURGICAL PROCEDURES

A method of cataract surgery in an eye of a patient includes identifying a feature selected from the group consisting of an axis, a meridian, and a structure of an eye by corneal topography and forming fiducial mark incisions with a laser beam along the axis, meridian or structure in the cornea outside the optical zone of the eye. A laser cataract surgery system a laser source, a topography measurement system, an integrated optical subsystem, and a processor in operable communication with the laser source, corneal topography subsystem and the integrated optical system. The processor includes a tangible non-volatile computer readable medium comprising instructions to determine one of an axis, meridian and structure of an eye of the patient based on the measurements received from topography measurement system, and direct the treatment beam so as to incise radial fiducial mark incisions. 13.-. (canceled)4. The method of claim 20 , wherein the fiducial mark incisions are intrastromal corneal incisions.5. (canceled)6. The method of claim 20 , wherein a length of each fiducial mark incision is less than 1.5 mm.7. The method of claim 20 , wherein the step of measuring topography or tomography of the eye comprises measuring a corneal topography with one or more of a keratometry system claim 20 , an optical coherence tomography system claim 20 , a Placido disc topography system claim 20 , a Hartmann-Shack topography system claim 20 , a Scheimpflug image topography system claim 20 , a confocal tomography system claim 20 , or a low coherence reflectometry system819.-. (canceled)20. A method of laser-assisted cataract surgery in an eye of a patient claim 20 , comprising:measuring a topography or tomography of the eye without a patient interface contacting the eye;placing a patient interface in contact with the eye;determining locations and incision profiles of one or more fiducial marker incisions with the patient interface contacting the eye based on the topography or ...

A device for delivery of compositions to the eye

The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.

SYSTEM AND METHOD FOR LASER CORNEAL INCISIONS FOR KERATOPLASTY PROCEDURES

A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea. 19-. (canceled)10. An apparatus for treating a collagenous tissue structure , the apparatus comprising:a profiling system to measure a profile of a surface of the tissue, the profiling system capable of identifying folds of the tissue;a laser to generate a laser beam; anda processor comprising a tangible medium coupled to the laser and configured to receive data from the profiling system, the tangible medium embodying instructions to determine an incision profile based on the surface of the tissue.1120-. (canceled)21. A method of treating a cornea of an eye , the method comprising:measuring a profile of a posterior portion of the cornea;incising the cornea with a plurality of laser beam pulses to provide a channel in the tissue sized to receive an elongate structure having a fluid passing channel.22. The method of claim 21 , wherein the tissue is incised in response to the profile such that the channel extends a distance from a posterior surface of the cornea to a location of the posterior portion of the cornea and wherein a fluid is advanced along the fluid passing channel to separate corneal tissue at the location and form a flap of tissue removed from the posterior portion of the cornea claim 21 , the flap having a thickness corresponding to the distance.23. The method of claim 21 , wherein the incision comprises a tunneling incision shaped to receive a needle and wherein the tunneling incision is oriented toward an access incision of the cornea to allow the needle to advance ...

SYSTEM AND METHOD OF CORNEAL CROSS-LINKING

The disclosure provides a system that may: receive data associated with multiple locations associated with a cornea of an eye; adjust at least one lens, based at least on diameter information of the data associated with at least one of the multiple locations, to set a diameter of a laser beam; and for each location of the multiple locations: determine if the eye has changed from a first position to a second position; if the eye has not changed from the first position to the second position, adjust, based at least on the location, at least one mirror; if the eye has changed from the first position to the second position, adjust, based at least on the location and based at least on the second position, the at least one mirror; produce the laser beam; and direct the laser beam to the location for a period of time. 1. A medical system , comprising:at least one processor;a laser that is communicatively coupled to the at least one processor and that is configured to produce one or more laser beams;at least one lens;at least one mirror; and receive data associated with a plurality of locations associated with a cornea of an eye of a patient;', 'adjust the at least one lens, based at least on diameter information of the data associated with at least one of the plurality of locations, to set a diameter of a laser beam; and', determine if the eye has changed from a first position of the eye to a second position of the eye, different from the first position of the eye;', 'if the eye has not changed from the first position of the eye to the second position of the eye, adjust, based at least on the location, the at least one mirror;', 'if the eye has changed from the first position of the eye to the second position of the eye, adjust, based at least on the location and based at least on the second position of the eye, the at least one mirror;', 'produce the laser beam; and', 'direct the laser beam to the location for a period of time associated with the location., 'for each ...

Device for laser cutting within transparent materials

A laser cutting device for transparent material ( 23 ), which device is designed to focus the laser light ( 2 ) into a plurality of predetermined spots within the material ( 23 ), wherein the spots lie on a predetermined cutting line or cutting area ( 24 ) running substantially perpendicularly to the direction of incidence of the laser light ( 2 ), wherein the device comprises means for mode conversion ( 3 ) into laser light having a helical phase front ( 5 ), which means can be brought into and out of the beam path of the laser light ( 2 ).

CUSTOMIZED LASER EPITHELIAL ABLATION SYSTEMS AND METHODS

Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness. 1. A method for treating an eye of a patient using a laser , the eye having an epithelial layer and a stromal layer , the method comprising:receiving, at a processor system, a refractive optical property of the eye;receiving, at the processor system, an epithelial thickness map of the eye;receiving, at the processor system, an epithelial basis data corresponding to an epithelial laser pulse ablation profile for a first individual laser beam pulse;receiving, at the processor system, a stromal basis data corresponding to a stromal laser pulse ablation profile for a second individual laser beam pulse; andexecuting, using the processor system, computer executable code stored on a non-transitory computer readable medium, the computer executable code comprising instructions for the laser to ablate the epithelial layer with an epithelial arrangement of laser beam pulses, the epithelial arrangement comprising the first individual laser pulse corresponding to the epithelial basis data and to ablate the stromal layer with a stromal arrangement of laser beam pulses, the stromal arrangement comprising the second individual laser pulse corresponding to the stromal basis data, the instructions based on the refractive optical property of the eye and the epithelial thickness map of the eye, thereby treating the eye of the ...

CONFORMABLE THERAPEUTIC SHIELD FOR VISION AND PAIN

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected. 1. A method of treating an eye of a patient , the eye comprising a cornea , an epithelium and a sclera , the method comprising: an inner portion having an inner rigidity and at least one inner radius of curvature; and', 'an outer portion having an outer rigidity and at least one outer radius of curvature;', 'wherein the inner rigidity is greater than the outer rigidity; and, 'providing a covering comprisingapplying the covering against the eye so that the covering flexes with the inner portion at least partially disposed over and substantially conforming to the cornea and with the outer portion engaging the eye along the epithelium, the sclera, or a combination thereof; wherein,the engagement holds the inner portion on the optical portion of the cornea;{'sup': 3', '3, 'the inner rigidity is from 2.5E-6 Pa-mto 6.41E-3 Pa-m; and'}{'sup': '3', 'the outer rigidity is no more than 4E-5 Pa-m.'}2. The method of claim 1 , wherein the inner portion comprises a first curved portion and the outer portion comprises a second curved portion and a third curved portion; and wherein:the first curved portion comprises a first lower surface having a first radius of ...

Conformable therapeutic shield for vision and pain

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

METHOD FOR SCANNING A PULSED LASER BEAM

Systems and methods of photoaltering a region of a material using a pulsed laser beam. The method includes scanning the pulsed laser beam in a first portion of the region with a first pattern, scanning the pulsed laser beam in a second portion of the region with a second pattern, and separating a flap of the material at the region. The system includes a laser, a controller selecting at least first and second patterns, and a scanner operable in response to the controller. The first pattern has a first maximum acceleration associated with the second portion, and the second pattern has a second maximum acceleration associated with the second portion. The second maximum acceleration is less than the first maximum acceleration. The scanner scans the pulsed laser beam from the laser in the first portion with the first pattern and in the second portion with the second pattern. 1. A method of photoaltering a sub-surface region of a patient's cornea using a pulsed laser beam to create a corneal flap , the sub-surface region having an outer periphery , a first portion defined within and circumscribed by the periphery , and a second portion smaller than and located within the first portion , the method comprising the steps of:transmitting the pulsed laser beam with a scanner to the first portion of the region in accordance with only a first laser scan pattern based on a continuous scan of the pulsed laser beam, the first laser scan pattern requiring a first maximum scanner movement acceleration associated with the second portion;transmitting the pulsed laser beam with a scanner to the second portion of the region in accordance with only a second laser scan pattern based on a continuous scan of the pulsed laser beam and that is different than the first laser scan pattern, the second laser scan pattern requiring a second maximum scanner movement acceleration associated with the second portion that is less than the first maximum scanner movement acceleration; andseparating a ...

SYSTEMS AND METHODS FOR PROVIDING ANATOMICAL FLAP CENTRATION FOR AN OPHTHALMIC LASER TREATMENT SYSTEM

Embodiments of this invention relate to systems and methods for providing anatomical flap centration for an ophthalmic laser treatment system. In one embodiment, the laser surgery system, having an imaging system and a suction ring coupled with a patient interface, captures a digital image of a subject's eye and identifies an optimum treatment placement of the corneal flap using anatomical markers as reference points. 1. An ophthalmic surgical laser system for creating a corneal flap on a subject's eye , comprising:a laser delivery system;a suction ring configured to overlay an anterior surface of the subject's eye, the suction ring operatively coupled to a patient interface, wherein the patient interface is coupled to the laser delivery system;an imaging system operatively coupled to the laser delivery system and configured to capture a digital image of the subject's eye with the suction ring overlaying the anterior surface of the eye; identifying one or more anatomical reference points in digital image captured by the imaging system;', 'calculating the location of the suction ring coupled to the patient interface relative to the reference points; and', 'identifying a location on the cornea to create the flap based on the location of the suction ring coupled to the patient interface relative to the reference points on the cornea., 'a computer-readable medium having a set of instructions that, when executed by a processor, identifies an optimum location for creating the corneal flap, wherein the set of instructions comprise2. The system of claim 1 , wherein the set of instructions includes centrating the location on the cornea to create the flap based on the location of the suction ring coupled to the patient interface relative to the one or more reference points on the cornea.3. The system of claim 1 , wherein the laser delivery system is a ultra-short pulsed laser system.4. The system of claim 1 , wherein the set of instructions includes generating an overlay on ...

Real-Time Laser Modulation And Delivery In Ophthalmic Devices For Scanning, Imaging, And Laser Treatment Of The Eye

Systems and methods of real-time laser control and modulation for ophthalmic devices are described. The systems and methods can be used for precise laser delivery at sub-micron resolution in both laser treatment and scan imaging processes. In various embodiments, the systems can include a laser delivery device useful for surgical eye treatment, a laser delivery device useful for an ophthalmic scan imaging device, or both. In one embodiment, the system includes a laser surgery device integrated with a scan-based ophthalmic imaging apparatus. In such an embodiment, an eye motion signal obtained from the imaging apparatus can be used to provide fine-tuned control of the operation of the surgical laser beam in the laser surgery device. 1. An ophthalmic laser surgery system , comprising:an ophthalmic imaging apparatus,a surgical light source, anda steering mirror communicatively coupled with the imaging apparatus,wherein the steering mirror is located in the pupil conjugate plain of a subject's eye, andwherein when the steering mirror directs a laser beam from the surgical light source onto the subject's eye, backscattered light from the subject's eye is received by the imaging apparatus; the imaging apparatus tracks a motion of the subject's eye from the backscattered light; and the imaging apparatus sends a control signal based on the motion of the subject's eye to the steering mirror to direct the location of the laser beam.2. The system of claim 1 , further comprising a wavefront sensor for detecting an aberration in the subject's eye.3. The system of claim 2 , further comprising a beam splitter for splitting the beam of backscattered light claim 2 , wherein a portion of the backscattered light is sent to the imaging apparatus and a portion of the backscattered light is sent to the wavefront sensor.4. The system of claim 2 , further comprising a stabilization/wavefront corrector communicatively coupled with the imaging apparatus and wavefront sensor.5. The system of ...

METHODS AND SYSTEMS FOR OPTHALMIC MEASUREMENTS AND LASER SURGERY AND METHODS AND SYSTEMS FOR SURGICAL PLANNING BASED THEREON

An ophthalmic measurement and laser surgery system includes: a laser source; a corneal topography subsystem; an axis determining subsystem; a ranging subsystem comprising an Optical Coherence Tomographer (OCT); and a refractive index determining subsystem. All of the subsystems are under the operative control of a controller. The controller is configure to: operate the corneal topography subsystem to obtain corneal surface information; operate the axis determining subsystem to identify one or more ophthalmic axes of the eye; operate the OCT to sequentially scan the eye in a plurality of OCT scan patterns, the plurality of scan patterns configured to determine an axial length of the eye; operate the refractive index determining subsystem so to determine an index of refraction of one or more ophthalmic tissues, wherein at least one of the corneal surface information, ophthalmic axis information, and axial length is modified based on the determined index of refraction. 1. An ophthalmic measurement and laser surgery system , comprising:a laser source configured to produce a pulsed laser beam;a corneal topography subsystem;an axis determining subsystem;a ranging subsystem comprising an Optical Coherence Tomographer (OCT);a refractive index determining subsystem;each of the laser source, the corneal topography subsystem, the axis determining subsystem, and the refractive index determining subsystem under the operative control of a controller, wherein the controller is configure to:operate the corneal topography subsystem to obtain corneal surface information;operate the axis determining subsystem to identify one or more ophthalmic axes of the eye;operate the OCT to sequentially scan the eye in a plurality of OCT scan patterns, the plurality of scan patterns configured to determine an axial length of the eye;operate the refractive index determining subsystem so to determine an index of refraction of one or more ophthalmic tissues,wherein at least one of the corneal surface ...

METHOD AND APPARATUS FOR TREATMENT OF OCULAR TISSUE USING COMBINED MODALITIES

A method is provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as peri-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that enables cross-linking (CXL) therapy to be combined with thermal therapy. 1. A method for treating ocular tissue comprising:directing laser radiation in a high absorption range of water to an ocular surface and subsurface region below the ocular surface, wherein the laser radiation modifies the shape of the ocular surface;delivering a cross-linking agent at a depth below the irradiated surface of the ocular tissue at or near the subsurface regions; anddirecting ultraviolet radiation to the ocular surface to promote collagen cross-linking at or near the subsurface region to stabilize the modified shape of the ocular surface, wherein the cross-linking agent promotes the crosslinking.2. The method of claim 1 , wherein the ocular surface is a cornea surface.3. The method of claim 1 , wherein thermal remodeling of the subsurface region induced by the laser radiation modifies the shape of the ocular surface.4. The method of claim 1 , further comprising cooling the ocular surface to prevent thermal remodeling of the surface region and control temperature of the subsurface regions.5. The method of claim 1 , wherein the ultraviolet radiation is delivered in a pulsed and fractionated format to minimize trauma to ocular tissue and to ...

TREATMENT TO IMPROVE ADHESIVE PROPERTIES OF CORNEAL IMPLANT

A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue. 1. A method comprising:improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on said ocular implant, said implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, said corneal adhesive layer having greater adhesive strength than a rest of said corneal tissue.2. The method according to claim 1 , wherein forming said implant adhesive layer is done by making chemical and/or physical changes on an anterior surface of said implant that make said implant adhesive layer more adhesive than the rest of said implant.3. The method according to claim 1 , wherein forming said corneal adhesive layer is done by making chemical and/or physical changes on the posterior surface of said corneal tissue that make said corneal adhesive layer more adhesive than the rest of said corneal tissue.4. The method according to claim 2 , wherein forming said implant adhesive layer is done by application of laser energy on the anterior surface of said implant.5. The method according to claim 2 , wherein forming said implant adhesive layer is done by application of chemicals on the anterior surface of said implant.6. The method according to claim 2 , wherein forming said implant adhesive layer is done by application of heat treatment on the anterior surface of said implant.7. The method according to claim 2 , wherein forming said implant adhesive layer is done by plasma treatment of the anterior surface ...

Method for delivery of compositions to the eye

The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.

Apparatus and method for performing surgical treatments of the eye

The present invention relates to an apparatus and a method for performing surgical treatments of the eye, in particular of the eye cornea, including a laser device, which is arranged to emit pulsed treatment radiation having a wavelength between about 380 nm and 425 nm and a pulse duration between 0.1 ps and 10 ns, wherein the pulse energy of the treatment radiation is between 0.1 nJ and 5 μJ.

ENHANCED VISUALLY DIRECTED PROCEDURES UNDER LOW AMBIENT LIGHT CONDITIONS

Performance of enhanced visually directed procedures under low ambient lighting conditions. An imaging system includes a first high resolution photosensor configured to acquire at least one first real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light. A second high resolution photosensor is configured to acquire at least one second real-time high resolution video signal representing the at least one view of the eye inside of the wavelengths of visible light. A control unit is configured to acquire the at least one first real-time high resolution video signal and the at least one second real-time high resolution video signal after the light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter, via the first and the second high resolution photosensor, respectively. 1. An imaging system comprising:a first high resolution photosensor configured to acquire at least one first real-time high resolution video signal representing at least one view of an eye in at least one wavelength of light outside of wavelengths of visible light;a second high resolution photosensor configured to acquire at least one second real-time high resolution video signal representing the at least one view of the eye in the visible light; acquire the at least one first real-time high resolution video signal and the at least one second real-time high resolution video signal after light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter, via the first high resolution photosensor and the second high resolution photosensor, respectively;', 'convert the at least one view corresponding to the at least one first real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light into at least one wavelength ...

METHOD OF TRANSPLANTING A CORNEA

A method of transplanting a cornea from a donor to a recipient is disclosed. An undercut is incised within stromal tissue of the donor cornea. Following formation of the undercut, the donor cornea is grafted onto a recipient. The undercut may be formed before or after the cornea is removed from the donor, and is preferably formed by photoaltering the stromal tissue using a laser. A sidecut may also be incised in the donor cornea, thereby forming a corneal flap, prior to grafting. In addition, a corneal section may be excised from the donor cornea using a trephine, a laser, or other appropriate surgical equipment. 113.-. (canceled)14. A method of transplanting a corneal section from a donor to a recipient in preparation for performing a Laser Assisted In-Situ Keratomileusis (“LASIK”) procedure , the method comprising:incising an undercut within stromal tissue of a donor cornea of a donor, wherein the donor cornea has an anterior surface, and wherein the undercut is incised posterior to the anterior surface of the donor cornea so that underlying stromal tissue of the donor cornea is disposed posterior to the undercut and overlying stromal tissue of the donor cornea is disposed anterior to the undercut;incising a sidecut in the donor cornea such that the combination of the sidecut and the undercut create a corneal flap having a hinge portion, the underlying stromal tissue connected with the overlying stromal tissue via the hinge portion on one side of the corneal flap, the underlying stromal tissue unconnected with the overlying stromal tissue on a second side of the corneal flap opposing the first side;after forming the corneal flap in the donor cornea, excising a corneal section containing the corneal flap from the donor cornea; andgrafting the incised corneal section onto an eye of a recipient;wherein, after the donor corneal section is grafted onto the eye of the recipient, the underlying stromal tissue of the donor corneal section is located immediately below the ...

Ophthalmological treatment apparatus

Disclosed is an ophthalmological treatment apparatus for modifying a shape of a corneal surface of a human eye. The apparatus includes a surgical laser device for implementing tissue cuts. The apparatus further includes a computerized control device in operative coupling with the surgical laser device, the control device being designed to control the laser device to implement tissue cuts according to a cut geometry with a primary tissue cut and a secondary tissue cut, wherein the primary tissue cut is a relief cut and extends into the depth of the corneal eye tissue, and wherein the secondary tissue cut lies within the corneal eye tissue, such that the secondary tissue cut adds to the relieving effect of the primary tissue cut.

LASER APPARATUS AND METHOD FOR REFRACTIVE SURGERY

An ultrashort pulsed laser instrument is used to perform refractive surgery. The invention operates in ablative and incisional modalities. In the ablative mode, spiral ablation disks consisting of individual laser pulses are produced at high scanning speeds. Ablation profile may be produced in cornea by stacking and arranging multiple ablation disks to produce a specified shape change. Placement of ablation disks is assisted by an optical tracking and control system that compensates for eye motion. A preferred embodiment allows for ablative corrections to be performed on non-planar posterior surface of a laser cut flap affixed to registration platen, thereby avoiding exposing the eye interior to high radiant power. Laser cut and contrast agent dyed fiduciary marks may serve as reference features for the optical tracking system. Incisional procedures, such as corneal flaps for LASIK, may also be performed. 1. A laser instrument comprising:a laser source generating a laser pulse train of ultrashort duration pulses;an optical processing module configured to control and modulate said laser pulse train;a scanning beam delivery module for scanning in three dimensions the focal point of said laser pulse train;a focusing optics module for focusing said laser pulse train onto biological tissue for the purpose of removing said tissue;an optical tracking system for detecting relative lateral and axial motions between said laser pulse train and said tissue; anda means for adjusting and compensating the delivery of said laser pulse train to said tissue using said optical tracking system to correct for said lateral and axial motionswherein the laser pulse train of ultrashort duration pulses produce a discrete ablation sequence, and wherein a wavelength and intensity of the laser source remain unchanged during the production of the ablation sequence.2. The laser instrument of claim 1 , wherein the instrument removes a designated volume of said biological tissue through a series of ...

SYSTEM AND METHOD FOR MEASURING AND CORRECTING ASTIGMATISM USING LASER GENERATED CORNEAL INCISIONS

A laser system that includes a laser source emitting a laser beam along an axis and a keratometer. The keratometer includes a first set of individual light sources that are equally spaced from one another along a first ring and that direct a first light toward an eye and a second set of individual light sources that are equally spaced from another along a second ring and direct a second light toward the eye, wherein the first ring and said second ring are co-planar and concentric with one another about the axis. The laser system includes a telecentric lens that receives the first light and second light reflected off of the eye and a detector that receives light from the telecentric lens and forms an image. The laser system also includes a processor that receives signals from said detector representative of the image and determines an astigmatism axis of the eye based on the signals. 131-. (canceled)32. A method of placing a toric intraocular lens in a human eye , the method comprising:a. determining an axis of astigmatism of an eye having a cataractous lens;b. using a laser beam to perform a capsulotomy in the anterior lens capsule; whereby the laser beam cuts a capsular opening in the anterior lens capsule; wherein the capsular opening comprises a tag aligned with the axis of astigmatism;c. the tag having slow curves without sharp edges, whereby the risk of radial capsular tears is avoided;d. removing the cataractous lens, wherein radial tearing of the capsular opening is avoided;e. determining the axis of astigmatism for a toric intraocular lens; and,f. inserting the toric intraocular lens through the capsular opening into the lens capsule and aligning the axis of astigmatism for the toric intraocular lens with the tag; wherein radial tearing of the capsular opening is avoided.33. The method of claim 32 , wherein the tag is positioned inwardly of the capsular opening.34. The method of claim 32 , wherein the tag is positioned outwardly of the opening.35. The method ...

Enhanced visually directed procedures under low ambient light conditions

Performance of enhanced visually directed procedures under low ambient lighting conditions. A computer readable medium storing a set of computer instructions for performing an enhanced visually directed procedure under low ambient visible light on a patient's eye. The computer instructions include: acquiring at least one real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light. The computer instructions include converting the at least one view is converted corresponding to the at least one real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light into at least one wavelength of visible light. The at least one high resolution photosensor is acquired after light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter.

SYSTEM AND METHOD FOR MEASURING AND CORRECTING ASTIGMATISM USING LASER GENERATED CORNEAL INCISIONS

A laser system that includes a laser source emitting a laser beam along an axis and a keratometer. The keratometer includes a first set of individual light sources that are equally spaced from one another along a first ring and that direct a first light toward an eye and a second set of individual light sources that are equally spaced from another along a second ring and direct a second light toward the eye, wherein the first ring and said second ring are co-planar and concentric with one another about the axis. The laser system includes a telecentric lens that receives the first light and second light reflected off of the eye and a detector that receives light from the telecentric lens and forms an image. The laser system also includes a processor that receives signals from said detector representative of the image and determines an astigmatism axis of the eye based on the signals. 131-. (canceled)32. A method of determining properties of an eye , the method comprising:measuring properties of an astigmatism axis of an eye determining a first reflected ring image of the eye to be an ellipse, determining a second reflected ring image of the eye to be an ellipse; determining clock angles of the ellipses; and determining an astigmatism axis of the eye based upon the clock angles;wherein the reflected ring images have diameters of from 1.5 mm to 3 mm;positioning the eye to receive a treatment laser beam that is emitted by a treatment laser source along a treatment laser beam axis; and,aligning the therapeutic laser beam axis with the determined astigmatic axis.33. The method of claim 32 , wherein an optical power of a steep axis and a shallow axis of the eye is determined.34. The method of claim 32 , comprising: controlling the treatment laser beam whereby the treatment laser beam performs a cutting of the eye based on the determined astigmatism axis.35. The method of claim 34 , wherein the cutting of the eye generates a mark representative of an orientation of the ...

TREATMENT OF OPHTHALMIC CONDITIONS

Ophthalmic conditions such as presbyopia, myopia, and astigmatism can be corrected by the use of a molding contact lens in combination with a pharmaceutical composition suitable for delivery to the eye. The molding contact lenses are preferably commercially available and are not specifically designed for orthokeratology. The agents in the pharmaceutical compositions such as hyaluronase allow the cornea of the eye to be molded in order to correct the refractive error of the eye. The contact lenses and the pharmaceutical composition induce a change in the radius of curvature of the anterior surface of the cornea, thereby correcting the refractive error of the eye. One advantage of the inventive technique is that the patient with his or her own individual visual needs guides the treatment until the patient near and far visual needs are met. The present invention also provides for kits, which contain molding contact lenses, pharmaceutical composition suitable for delivery to the eye, and instructions, useful in the inventive system. 149-. (canceled)50. A non-invasive method for treating an ophthalmic condition associated with an error in refraction of the eye , the method comprising steps of:providing a contact lens;{'b': '1', 'providing eye drops comprising an effective amount of hyaluronidase and collagenase, wherein the collagenase is not matrix metalloproteinase or matrix metalloproteinase 2;'}applying the contact lens to an eye of a patient suffering from the ophthalmic condition; andapplying the eye drops to the eye of the patient;wherein the treatment corrects the patient's vision, and the treatment results in corrected vision for at least 6 months.51. The method of claim 50 , wherein the contact lens is an extended wear contact lens.52. The method of claim 50 , wherein the contact lens is a gas permeable contact lens.53. The method of claim 50 , wherein the contact lens is a molding contact lens.54. The method of claim 50 , wherein the treatment induces a change ...

SYSTEM AND METHOD FOR LASER CORNEAL INCISIONS FOR KERATOPLASTY PROCEDURES

A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea. 1. A method of treating a cornea of an eye , the method comprising:measuring a profile of a posterior portion of the cornea;incising the cornea with a beam pulse profile based on the profile of the posterior portion.2. The method of claim 1 , wherein the cornea is treated so as to inhibit light scatter at a treated posterior surface of the treated cornea.3. The method of claim 1 , further comprising:measuring folds of the posterior portion of the cornea, wherein the beam pulse profile extends along the posterior portion in response to the folds to inhibit transecting lamella of the stroma.4. The method of claim 1 , wherein the posterior portion comprises an irregular posterior surface claim 1 , and wherein the beam pulse profile provides an irregular incision profile corresponding to the irregular posterior surface.5. A method as in claim 4 , wherein the irregular posterior surface corresponds to folds of stromal lamella of the cornea and wherein the irregular incision profile decreases transaction of the stromal lamella.6. The method of claim 5 , wherein a donor cornea comprises an irregular donor posterior surface corresponding to donor folds of donor stromal lamella of the donor cornea and wherein an irregular donor incision profile corresponding to the donor folds of the donor stromal lamella decreases transaction of the donor stromal lamella.7. The method of claim 1 , wherein the profile corresponds to folds of a Descemet's membrane of the cornea and wherein the incision profile ...

CORNEAL TOPOGRAPHY MEASUREMENTS AND FIDUCIAL MARK INCISIONS IN LASER SURGICAL PROCEDURES

A method of cataract surgery in an eye of a patient includes identifying a feature selected from the group consisting of an axis, a meridian, and a structure of an eye by corneal topography and forming fiducial mark incisions with a laser beam along the axis, meridian or structure in the cornea outside the optical zone of the eye. A laser cataract surgery system a laser source, a topography measurement system, an integrated optical subsystem, and a processor in operable communication with the laser source, corneal topography subsystem and the integrated optical system. The processor includes a tangible non-volatile computer readable medium comprising instructions to determine one of an axis, meridian and structure of an eye of the patient based on the measurements received from topography measurement system, and direct the treatment beam so as to incise radial fiducial mark incisions. 1. A method of cataract surgery in an eye of a patient comprising:identifying a feature selected from the group consisting of an axis, a meridian, and a structure of an eye by corneal topography;forming fiducial mark incisions with a laser beam along the axis, meridian or structure in the cornea outside the optical zone of the eye.2. The method of claim 1 , wherein the feature is a meridian of the cornea.3. The method of claim 2 , wherein the meridian is the steepest meridian.4. The method of claim 1 , wherein the fiducial mark incisions are instrasomal corneal incisions.5. The method of claim 1 , wherein the fiducial mark incisions do not alter the optical properties of the eye.6. The method of claim 5 , wherein the length of each fiducial mark incision is less than 1.5 mm.7. The method of claim 1 , wherein identifying the feature comprises measuring the corneal topography with one or more of a keratometry system claim 1 , an optical coherence tomography system claim 1 , a Placido disc topography system claim 1 , a Hartmann-Shack topography system claim 1 , a Scheimpflug image ...

APPARATUS FOR EYE LASER SURGERY AND METHOD FOR PERFORMING A TRANSEPITHELIAL PHOTOREFRACTIVE KERATECTOMY

An apparatus for laser eye surgery comprises a laser module, which is equipped to emit pulsed, focused laser radiation of a variable pulse repetition rate, and a processor-based control unit, which is equipped to receive at least one user input pertaining to a selection of one of several predefined pulse repetition rates over a user input and to control the laser module in accordance with the selected pulse repetition rate. In certain specific embodiments, the user interface enables input of two user entries, each of which relates to a selection of one of several predefined pulse repetition rates. The control unit controls the laser module for a first phase of a laser treatment in accordance with one input, and for a second phase of the laser treatment, it controls the laser module in accordance with the other input. 1. An apparatus for eye laser surgery , comprising:a laser assembly configured to emit pulsed focused laser radiation having a variable pulse repetition rate; and receive at least one user input related to a selection of one from a plurality of pre-defined pulse repetition rates through a user interface; and', 'control the laser assembly in accordance with the at least one selected pulse repetition rate., 'a processor based control unit configured to2. The apparatus of claim 1 , wherein the user interface includes a graphical user interface displayed on a display screen.3. The apparatus of claim 2 , wherein the graphical user interface includes at least one drop-down menu adapted to allow a selection from at least two pre-defined pulse repetition rates.4. The apparatus of claim 1 , wherein the control unit is configured to:receive the at least one user input in association with patient-specific data; andstore each selected pulse repetition rate in association with the patient-specific data in a storage medium.5. The apparatus of claim 1 , wherein the control unit is configured to:receive two user inputs each related to a selection of one from a ...

LASER EYE SURGERY LENS FRAGMENTATION

A laser eye surgery system includes a laser to generate a laser beam. A spatial measurement system generates a measurement beam and measure a spatial disposition of an eye. A processor is coupled to the laser and the spatial measurement system, the processor comprising a tangible medium embodying instructions to determine a spatial model of the eye in an eye coordinate reference system based on the measurement beam. The spatial model is mapped from the eye coordinate reference system to a machine coordinate reference system. A laser fragmentation pattern is determined based on a plurality of laser fragmentation parameters. The laser fragmentation pattern and the spatial model is rotated by a first rotation angle such that the spatial model is aligned with the reference axis of the machine coordinate reference system and the rotated laser fragmentation pattern is aligned with the corneal incision. 1. A laser eye surgery system , comprising:a laser to generate a laser beam;a spatial measurement system to generate a measurement beam and measure a spatial disposition of an eye;a processor coupled to the laser and the spatial measurement system, the processor comprising a tangible medium embodying instructions to:determine a spatial model of the eye in an eye coordinate reference system based on the measurement beam;map the spatial model from the eye coordinate reference system to a machine coordinate reference system;receive a rotation angle of a corneal incision relative to a reference axis of the machine coordinate reference system;determine a laser fragmentation pattern based on a plurality of laser fragmentation parameters;determine a first rotation angle based on the rotation angle of the corneal incision and a rotation angle of the laser fragmentation pattern relative to the reference axis of the machine coordinate reference system;rotate the spatial model by a negative of the first rotation angle; androtate the laser fragmentation pattern and the spatial model by ...

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

A system for ophthalmic surgery includes a laser source configured to deliver an ultraviolet laser beam comprising laser pulses having a wavelength between 320 nm and 370 nm to photodecompose one or more intraocular targets within the eye with chromophore absorbance. The pulse energy, the pulse duration, and the focal spot are such that an irradiance at the focal spot is sufficient to photodecompose the one or more intraocular targets without exceeding a threshold of formation of a plasma and an associated cavitation event. An optical system operatively coupled to the laser source and configured to focus the ultraviolet laser beam to a focal spot and direct the focal spot in a pattern into the one or more intraocular targets. The optical system focuses the laser beam at a numerical aperture that provides for the focal spot to be scanned over a scan range of 6 mm to 10 mm. 120.-. (canceled)21. A system for ophthalmic surgery of an eye of a patient , comprising:a laser source, configured to alternatively deliver an ultraviolet treatment laser beam and an ultraviolet probe laser beam, each laser beam comprising a plurality of ultraviolet laser pulses, wherein a pulse energy of the ultraviolet probe laser beam is lower than a pulse energy of the ultraviolet treatment laser beam;an optical system operatively coupled to the laser source and configured to direct the laser beams;an imaging system operatively coupled to the laser source and optical system and configured to detect a back reflected light from the eye; anda controller coupled to the laser source, the optical system and the imaging system, and programmed to operate the laser source, the optical system and the imaging system to:focus the ultraviolet probe laser beam to a focal spot and direct the focal spot of the ultraviolet probe laser beam in a first imaging scan pattern into a first intraocular target of the eye and to confocally detect back reflected light of the probe laser beam from the first intraocular ...

Apparatus for the treatment of the cornea

LASER EYE SURGERY LENS FRAGMENTATION

A laser eye surgery system includes a laser to generate a laser beam. A spatial measurement system generates a measurement beam and measure a spatial disposition of an eye. A processor is coupled to the laser and the spatial measurement system, the processor comprising a tangible medium embodying instructions to determine a spatial model of the eye in an eye coordinate reference system based on the measurement beam. The spatial model is mapped from the eye coordinate reference system to a machine coordinate reference system. A laser fragmentation pattern is determined based on a plurality of laser fragmentation parameters. The laser fragmentation pattern and the spatial model is rotated by a first rotation angle such that the spatial model is aligned with the reference axis of the machine coordinate reference system and the rotated laser fragmentation pattern is aligned with the corneal incision. 117.-. (canceled)18. A method of treating an eye with a laser beam , comprising:measuring a plurality of characteristics of the eye by an eye sensor;determining a model of the eye based on the measured characteristics;receiving a rotation angle of an incision relative to a reference coordinate space;generating a laser fragmentation pattern for treating the eye;rotating the laser fragmentation pattern by the received rotation angle relative to the reference coordinate space; andapplying a laser beam by a laser source to a lens of the eye based on the rotated laser fragmentation pattern.19. The method of claim 18 , wherein the model is aligned with the reference coordinate space and the rotated laser fragmentation pattern is aligned with the incision.20. A method of treating an eye with a lens fragmentation pattern claim 18 , comprising:measuring a plurality of characteristics of an eye by a laser surgery system;determining a spherical model of the eye based on the measured characteristics;determining lens segmentation boundaries based on the spherical model;receiving a ...

用于巩膜的医学治疗的装置

本发明提供用于巩膜的医学治疗的装置，该装置包括连接至轴的单个施加器，其中，该施加器被构造为放入特农氏空间中；该施加器具有第一表面，其中，施加器的第一表面可表面接触巩膜的区域的表面以便表面覆盖所述区域；并且该施加器包括连接至从轴的近端向施加器的第一表面处的单个远端光学出口延伸的单个光学引导元件的单个光学出口，该光学引导元件被构造为朝向光学出口引导电磁波，其中，光学引导元件被构造为通过蛋白质凝固引导适于巩膜的热治疗的波长的电磁波。

Method for reshaping the eye

A method for modifying tissue with a quasi-continuous laser beam to change the optical properties of the eye comprises controllably setting the volumetric power density of the beam and selecting a desired wavelength for the beam. Tissue modification is accomplished by focusing the beam at a preselected start point in the tissue and moving the beam's focal point in a predetermined manner relative to the start point throughout a specified volume of the tissue or along a specified path in the tissue. Depending on the selected volumetric power density, the tissue on which the focal point is incident can be modified either by photoablation or by a change in the tissue's visco-elastic properties.

Non-invasive thermometry in organs under hyperthermia and coagulation conditions

The ultrasonic reflectometry is used for monitoring or controlling thermally induced, biological effects. Also using ultrasonic reflectometry with laser radiation, temp. gradients, coagulated or denatured vols. are determined also are used for therapy control or for control of the laser. The medical method of the diagnostic ultrasonic A-scan is used, yet these specific electronic detector units are replaced or supplemented by an integrator technology, e.g. according to the box car principle. The specific detector units are supplemented by a synchronising unit for identifying the patient movements.

Lenticule Separator for SMILE Surgery

Disclosed is a lenticule separator for smile surgery, capable of minimizing the damage to an eyeball. The lenticule separator for smile surgery according to an embodiment of the present invention comprises a scraper and a handle. The scraper is formed to be long, and thus have a length in one direction. A lower surface of the scraper passes through a flap surface and a lenticule surface while having the same curvature radius as the flap surface in a length direction. The scraper cuts a tissue bridge between the cornea and the lenticule to separate the lenticule. The handle has a length in the same direction as the scraper. The handle is connected to one end of the scraper to have an inclination upward, so that a user can grasp the handle.

Cross-linking of eye tissue

The present disclosure relates to the cross-linking of eye tissue. Embodiments of the disclosure relate to the activation of a photosensitizer and/or nanoparticles for the cross-linking of eye tissue.

Apparatus and method for shrinking collagen

The present invention provides a device, a system, and associated methods for advantageously treating bodily tissues containing collagen, such as the cornea. The device is a topical device that, when placed over the target tissue, defines a space between an inner surface of the device and the tissue. The radiation-transparent device allows radiation to pass therethrough to the tissue during the radiation treatment. The device is believed to reduce heat loss, such as evaporative heat loss, from the tissue, thereby improving the tissue-heating efficiency of the radiation treatment. Typical radiation treatment parameters may thus be adjusted to provide a more gentle, yet highly efficient treatment using the inventive device. The gentle treatment reduces the likelihood of thermally traumatizing the treated tissue. While the invention has particular application in the area of corneal treatment, it may be used to prepare other tissues or substrates.

Crosslinking of ocular tissue

本公开涉及眼组织的交联。本公开的实施方案涉及激活光敏剂和/或纳米粒以用于眼组织的交联。

Systems and methods for reshaping an eye feature

Systems and methods include a cutting instrument that creates incisions in selected areas of the cornea; an eye therapy system that applies reshaping forces to the cornea; and a controller that determines the selected areas of the cornea for the incisions and the reshaping forces from the eye therapy system, such that the reshaping forces and the incisions combine to achieve corrective reshaping of the cornea. Other systems and methods include measuring an eye to determine a required amount of reshaping of a cornea; determining one or more doses of cross-linking agent and one or more corresponding doses of photoactivating light according to the required amount of reshaping; applying the cross-linking agent to the cornea; and delivering, from a light source, the photoactivating light to the area of the eye, the photoactivating light combining with the cross-linking agent to induce the corrective reshaping of the cornea.

System and method for laser keratotomy for corneal transplantation

Use of corneal hardening agent in enzyme orthokeratology

提供一种纠正哺乳动物眼屈光不正的酶学角膜曲率矫正术。促进角膜再成形是通过给眼睛施用角膜硬化剂量的角膜硬化剂实现的。重新成形是在硬接触镜的影响下或在一系列具有能纠正屈光不正之凹面曲率的镜片的影响下完成的。角膜迅速将其凸面曲率再成形为接触镜片的凹面曲率，形成正视眼。允许角膜“硬化”以维持新的正视眼形状。“硬化”发生后将调整为正视眼的镜片拿掉。

Apparatus and method for operating a real time large diopter range sequential wavefront sensor

一种顺序波前传感器，包括：光源(172)；光束偏转元件(112)；位置感测检测器(122)，配置成输出多个输出信号以及多个复合互阻抗放大器(见图11)，每一个复合互阻抗放大器被耦合成接收检测器输出信号中的一个。每一个复合互阻抗放大器的输出被锁相至光源驱动信号和光束偏转元件驱动信号。

Short pulse mid-infrared parametric generator for surgery

公开了一种用于外科手术应用的激光参数发生器,该激光参数发生器利用短脉冲,中红外辐射。中红外辐射可由泵激激光源(20),例如掺钕激光器产生,泵激激光源(20)提供的辐射在适当的非线性晶体(15)中被参数下变频到要求的中红外范围。短脉冲把邻近区域中的不希望的热影响和变化降低到亚微米级。参数下变频的辐射源最好在3.0微米或3.0微米左右,不过最好接近与组织相关的水吸收最大值下产生脉冲持续时间小于25纳秒的辐射。下变频到要求的中红外波长最好由非线性晶体(15),例如KTP或其同晶型体产生。在一个实施例中,使用非临界相位匹配晶体把来自近红外源发射的880－900纳米或880－900纳米左右的波长变换到要求的2.9－3.0微米波长范围。作为本发明的一部分,使用光纤、束光纤或另一波导管装置使泵激激光器与光学参数振荡器(OPO)空腔分开。

Integrated surgical microscope and wavefront sensor

A wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated wavefront measurements of a patient's eye while the patient remains on an operating table in the surgical position. The device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap. The inclusion of lightweight, compact diffractive optical components in the wavefront sensor allows the integrated device to be supported on a balancing mechanism above a patient's head during a surgical procedure. As a result, the need to reposition the device and/or the patient between measuring optical properties of the eye and performing surgical procedures on the eye is eliminated. Many surgical procedures may be improved or enhanced using the integrated device, including but not limited to cataract surgery, Conductive Keratoplasty, Lasik surgery, and corneal corrective surgery.

Method and apparatus for analysis and correction of abnormal refractive errors of the eye

The invention contemplates instrumentation to aid in performing refraction-corrective surgery on the conrea, (1) by determining the topography of the anterior surface of the cornea, the determination being in the form of digitized data entered into computer storage, (2) by determining the local thickness of the cornea along multiple axes, the determination being also in the form of digitized data entered into computer storage, and (3) by providing a CAD/CAM display of both categories of data, correlated as appropriate for the surgeon's selective display of a corneal region, aspect or section, as the surgeon may deem pertinent to a prospective operation.

Apparatus and method for altering corneal tissue

An apparatus and method for treating vision disorders is disclosed. The apparatus and method incorporate a cutter which cuts into the corneal tissue of an eye. The corneal tissue proximate the lower region of the cut is then heated by, for instance, a laser which causes the tissue at that predetermined region to shrink. The shrinkage moves the cut plug with respect to the remainder of the eye to change the shape of the corneal surface and correct the problematic refractive error.

Corneal topography measurement and alignment of corneal surgical procedures

Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

CUTTING DEVICE WITH OPTICAL COUPLER INCLUDING A POLARIZATION CORRECTOR

L’invention concerne un un appareil découpe incluant : une source LASER (1) pour émettre un faisceau LASER initial (11) sous la forme d’impulsions, un système de mise en forme (2) positionné en aval du laser femtoseconde (1), pour transformer le faisceau LASER initial (11) en un unique faisceau LASER modulé en phase, un coupleur optique (3) entre la source LASER (1) et le système de mise en forme (2), le coupleur optique (3) incluant une fibre optique (31), remarquable en ce que l’appareil de découpe comprend en outre un correcteur de polarisation (7) pour modifier la polarisation du faisceau LASER initial (11) à une extrémité d’entrée du coupleur optique (3) de sorte que la polarisation du faisceau LASER à une extrémité de sortie du coupleur optique (3) corresponde à une polarisation de référence souhaitée). Figure à publier avec l’abrégé : Fig. 4 The invention relates to a cutting device including: a LASER source (1) for emitting an initial LASER beam (11) in the form of pulses, a shaping system (2) positioned downstream of the femtosecond laser (1) , to transform the initial LASER beam (11) into a single phase modulated LASER beam, an optical coupler (3) between the LASER source (1) and the shaping system (2), the optical coupler (3) including an optical fiber (31), remarkable in that the cutting apparatus further comprises a polarization corrector (7) to modify the polarization of the initial LASER beam (11) at an input end of the optical coupler (3) of so that the polarization of the LASER beam at an output end of the optical coupler (3) corresponds to a desired reference polarization). Figure to be published with abstract: Fig. 4

Ophthalmic laser surgical device for transepithelial laser refraction correction corneal resection

Method for surgical correction of hypermetropia

Изобретение относитс  к офтальмологии . Цель изобретени  -.предупреждение послеоперационных осложнений. Каждый полумеридиан раздел ют на дза части, причем периферическа  часть относитс  к центральной как 13, производ т надрез от лимба до границы с центральной частью, затем через чего ч слои стромы параллельно поверхности роговицы и до центральной оптической зоны ввод т наконечник коагул тора и осуществл ют коагул цию.

Device for laser cutting within transparent materials

A laser cutting device for transparent material ( 23 ), which device is designed to focus the laser light ( 2 ) into a plurality of predetermined spots within the material ( 23 ), wherein the spots lie on a predetermined cutting line or cutting area ( 24 ) running substantially perpendicularly to the direction of incidence of the laser light ( 2 ), wherein the device comprises means for mode conversion ( 3 ) into laser light having a helical phase front ( 5 ), which means can be brought into and out of the beam path of the laser light ( 2 ).

Method for realizing path planning of automatic mechanical operation arm

本发明涉及一种实现自动化机械操作臂路径规划的方法，包括机器操作臂和安装于所述机器操作臂上的手术刀，通过显微镜摄像系统并计算得到手术刀和目标点的位置，让机器操作臂沿着设定的路径进行运动，使得机器操作臂带着手术刀沿着设定的路径自动完成运动。

Method and apparatus for enhanced corneal accommodation

A method and apparatus related to enhancing corneal accommodation to address the effect of presbyopia. Corneal/scleral topology measurements in accommodation and non-accommodating states are indicative of a presbyopic subject~s nominal corneal accommodative power. A desired accommodative power intended to improve on the effect of presbyopia can be determined, suggesting a selective biomechanical intervention in the corneal structure outside of the optical zone to create flexure regions. These flexure regions would allow enhanced corneal accommodation upon presentation of an accommodating stimulus. Intervention could be in the form of, for example, corneal surface ablation, intrastromal ablation, conductive kerastoplasty (CK), laser thermal kerastoplasty (LTK), and corneal and/or scleral implants. An improved topology measuring apparatus having an improved field of view and other attributes is disclosed.