СПОСОБЫ И АППАРАТУРА ДЛЯ УВЕЛИЧЕНИЯ КОНЦЕНТРАЦИИ КИСЛОРОДА ДЛЯ УСОВЕРШЕНСТВОВАННЫХ ОФТАЛЬМОЛОГИЧЕСКИХ УСТРОЙСТВ

Группа изобретений относится к медицине. Контактная линза содержит: юбку гидрогеля, причем юбка гидрогеля отлита в форме контактной линзы и содержит дугообразную заднюю поверхность, расположенную вблизи роговицы пользователя во время использования контактной линзы; вставку, причем вставка содержит один или более компонентов, установленных на ней, при этом вставка является газонепроницаемой и непроницаемой для протекания жидкости через ее корпус; первую область юбки гидрогеля, причем первая область юбки гидрогеля представляет собой тот участок юбки гидрогеля, который находится между поверхностью вставки и роговицей пользователя во время использования контактной линзы; и средство в контактной линзе, предназначенное для увеличения уровней кислорода в жидкости, находящейся в контакте с первой областью, причем указанное средство содержит по меньшей мере одну прорезанную пору, продолжающуюся через вставку и расположенную так, чтобы находиться в жидкостном контакте с первой областью. Вставка содержит ...

СПОСОБЫ И АППАРАТУРА ДЛЯ УВЕЛИЧЕНИЯ КОНЦЕНТРАЦИИ КИСЛОРОДА ДЛЯ УСОВЕРШЕНСТВОВАННЫХ ОФТАЛЬМОЛОГИЧЕСКИХ УСТРОЙСТВ

ЭНДОПРОТЕЗ С ВЫРОВНЕННЫМИ НОЖКАМИ ДЛЯ УПРОЩЕНИЯ КАНЮЛЯЦИИ

... 1. Разветвленный эндопротез, содержащий:трансплантатный компонент и по меньшей мере один опорный компонент, совместно определяющие корпусную часть, первую ножечную часть и вторую ножечную часть; иразъемное крепление, выравнивающее первую ножечную часть и вторую ножечную часть относительно друг друга для упрощения канюляции второй ножечной части.2. Эндопротез по п. 1, в котором разъемное крепление содержит привязь, торцевая оконечность которой заправлена под неразвернутые части муфты, окружающей разветвленный эндопротез.3. Эндопротез по п. 1, в котором разъемное крепление содержит привязь, торцевая оконечность которой пропущена под одной или несколькими вершинами по меньшей мере одного опорного компонента.4. Эндопротез по п. 1, в котором первая ножечная часть, по существу, аксиально длинней второй ножечной части.5. Эндопротез по п. 1, в котором первая ножечная часть и вторая ножечная часть конструктивно отклонены под углом в разные стороны, образуя Y-образную конфигурацию.6. Эндопротез по ...

Implantable vein frame

An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

METHODS AND APPARATUS TO ENHANCE OXYGEN CONCENTRATIONS FOR ADVANCED OPHTHALMIC DEVICES

Methods and apparatus to enhance levels of oxygen in tear fluid under a worn advanced contact lens are described. The advanced contact lens may include an insert which is impermeable to fluid flow across its body. The method of enhancement may include creating pores through the insert, creating channels in portions of the contact lens body, including layers of absorptive material, including devices to generate or release oxygen or means of moving tear fluid under the contact lens.

ENDOPROSTHESIS HAVING ALIGNED LEGS FOR EASE OF CANNULATION

The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and at least two leg portions, wherein at least two legs are in an aligned configuration for ease of cannulation. The endoprosthesis comprises a removable restraint (245) aligning the two legs relative to each other. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also taught.

Implantable venous frame

URETHRAL PROSTHESIS WITH TENSIONING MEMBER

Urethral prosthesis (10) including a first and a second arm (20, 30) that join to form a junction (40), and a stem (50) that is also joined to the junction (40). The junction (40) is adapted to exert sufficient pressure on a portion of a patient's urethra to prevent unintentional voiding of the patient's bladder. However, upon exerting a tension force on the stem (50), the pressure exerted by the junction (40) is reduced such that the patient's bladder may be intentionally voided.

SEGMENTED SCAFFOLD DESIGNS

Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

Method for treating a wound using improved placental tissue graft

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located on top of and within the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high levels of laminin-5, a cell adhesion bio-active factor shown to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

IMPLANT WITH FIDUCIAL MARKERS

An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.

Placental tissue grafts and improved methods of preparing and using the same

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

ИСКУССТВЕННЫЙ ОРТОТОПИЧЕСКИЙ ЭНДОПРОТЕЗ МОЧЕВОГО ПУЗЫРЯ

... 1. Искусственный ортотопический эндопротез мочевого пузыря, отличающийся тем, что содержит первый участок (2), выполненный с возможностью соединения с уретрой пациента, и второй участок (3), выполненный с возможностью соединения с мочеточниками упомянутого пациента;причем упомянутый первый участок (2) содержит сжимающийся кожух (4), изготовленный из многослойной силиконовой мембраны, имеющей внешнюю поверхность (4а) и внутреннюю поверхность (4b), которые обе покрыты пиролитическим турбостратическим углеродом;упомянутый второй участок (3) содержит рассасывающуюся крышку (7), содержащую полотно (8) из волокон PGA, и раму (9), соединенную с упомянутой крышкой (7), изготовленной с использованием сополимер PGA/PLA; причем упомянутый кожух (4) и упомянутая крышка (7) соединяются вместе вдоль их соответствующих границ (4c, 7a), чтобы образовать оболочку.2. Эндопротез по п. 1, отличающийся тем, что кожух (4) содержит полоску (12), выступающую из упомянутого края (4с) кожуха (4) и изготовленную ...

GRAFT PREPARATION SYSTEM

Systems and methods for preparing a ligament graft for a ligament reconstruction procedure are provided. In general, the described techniques utilize a graft holder construct having a graft preparation holder and a suture assembly removably coupled thereto. The graft preparation holder includes an elongate support rail having a longitudinal axis, and a plurality of leaf segments positioned along the longitudinal axis in a spaced relationship and extending laterally from the support rail. The leaf segments can bend to a graft holding configuration so as to define a graft receiving channel configured to receive a graft therethrough. The holder also has at least one support structure configured to mate with the leaf segments to provide stability and rigidity to the segments. The suture assembly has at least one suture tail that can be pulled to affix the suture assembly to a graft without penetrating the graft.

Methods and devices for in situ formed nerve cap

Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth ...

METHODS AND DEVICES FOR IN SITU FORMED NERVE CAP

Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth ...

PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located on top of and within the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high levels of laminin-5, a cell adhesion bio-active factor shown to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

METHOD FOR AORTIC REPAIR AND AORTIC REPLACEMENT

An endovascularly deployed prosthetic includes a portion for being positioned within an ascending aorta. The prosthesis includes a replacement aortic valve on a proximal end thereof. The prosthesis includes an increased diameter portion that seals against the aorta at a more distal portion, and a pair of conduits extend from the increased diameter portion to the coronaries for fluidly coupling the coronaries to the prosthesis.

ИСКУССТВЕННЫЙ ОРТОТОПИЧЕСКИЙ ЭНДОПРОТЕЗ МОЧЕВОГО ПУЗЫРЯ

Изобретение относится к области медицинской техники, и в частности, к искусственному ортотопическому эндопротезу мочевого пузыря и может быть использовано при замене мочевого пузыря пациента, когда последний страдает серьезными неизлечимыми болезнями такими, которые подвергают риску правильную его работу. Искусственный ортотопический эндопротез мочевого пузыря содержит первый участок, выполненный с возможностью соединения с уретрой пациента, и второй участок, выполненный с возможностью соединения с мочеточниками упомянутого пациента. Первый участок содержит сжимающийся кожух, изготовленный из многослойной силиконовой мембраны, имеющей внешнюю поверхность и внутреннюю поверхность, которые обе покрыты пиролитическим турбостратическим углеродом. Второй участок содержит рассасывающуюся крышку, содержащую полотно из волокон PGA, и раму, соединенную с упомянутой крышкой, изготовленную с использованием сополимера PGA/PLA. Кожух и крышка соединяются вместе вдоль их соответствующих границ, чтобы ...

ИНТРАОКУЛЯРНАЯ ЛИНЗА С НЕПРОНИЦАЕМОЙ ПОВЕРХНОСТЬЮ

Группа изобретений относится к медицине. Интраокулярная линза, характеризующаяся тем, что линза имеет влагонепроницаемую поверхность, полученную посредством способа. При этом способ характеризуется тем, что: интраокулярную линзу подвергают воздействию окислительного механизма, в результате чего поверхность линзы переформировывается без нанесения покрытия или выполнения наращивания таким образом, что образуется влагонепроницаемая поверхность при сохранении неизменными объемных свойств линзы и водосодержания в линзе. Применение данной группы изобретений позволит предотвратить или уменьшить образование пятен в полимерной пленке. 2 н. и 12 з.п. ф-лы, 1 ил., 1 пр., 1 табл.

МЕДИЦИНСКИЙ ПРИБОР ДЛЯ ЗАХВАТЫВАНИЯ И ИЗВЛЕЧЕНИЯ ПОСТОРОННИХ ОБЪЕКТОВ ИЗ ПОЛОСТЕЙ ТЕЛА

MALE URETHRAL PROSTHESIS WITH TENSIONING MEMBER

URETHRAL PROSTHESIS WITH TENSIONING MEMBER

Urethral prosthesis (10) including a first and a second arm (20, 30) that join to form a junction (40), and a stem (50) that is also joined to the junction (40). The junction (40) is adapted to exert sufficient pressure on a portion of a patient's urethra to prevent unintentional voiding of the patient's bladder. However, upon exerting a tension force on the stem (50), the pressure exerted by the junction (40) is reduced such that the patient's bladder may be intentionally voided.

DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM

A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material incudes at least one porous expanded fluoropolymer layer and an elastomeric material substantially filling substantially all of the pores of the porous expanded fluoropolymer.

ENDOPROSTHESIS HAVING ALIGNED LEGS FOR EASE OF CANNULATION

The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and at least two leg portions, wherein at least two legs are in an aligned configuration for ease of cannulation. The endoprosthesis comprises a removable restraint (245) aligning the two legs relative to each other. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also taught.

HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS

High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a single aryl hydrophobic monomer as a device forming monomer. In addition, the copolymers comprise a non-polymerizable block copolymer surfactant. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures.

LIQUEFACTION OF BONE MATRIX

The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.

OCULAR IMPLANT IRIS DIAPHRAGM

An ocular implant alters iris color for medical and cosmetic purposes and is made of an inert, nontoxic, foldable and preferably permeable to fluid flow material. It is an annular non-planar structure that fits over the iris yet leaves the natural lens uncovered and extends approximately to the iridocorneal angle. Two different kinds of arc sections of a non-uniform thickness make up the structure: passage arc sections and support arc sections. The passage arc sections permit humor aqueous flow under the implant. The support arc sections make contact with the iris and provide the necessary support for the passage arc sections. Auricles extend from the support arc sections and are configured to hold the implant in place by engaging the eye at the iridocorneal angle. The implant may include an artificial lens, a limbal ring, and various means to anchor for the artificial lens.

OCULAR IMPLANT IRIS DIAPHRAGM

An ocular implant alters iris color for medical and cosmetic purposes and is made of an inert, nontoxic, foldable and preferably permeable to fluid flow material. It is an annular non-planar structure that fits over the iris yet leaves the natural lens uncovered and extends approximately to the iridocorneal angle. Two different kinds of arc sections of a non-uniform thickness make up the structure: passage arc sections and support arc sections. The passage arc sections permit humor aqueous flow under the implant. The support arc sections make contact with the iris and provide the necessary support for the passage arc sections. Auricles extend from the support arc sections and are configured to hold the implant in place by engaging the eye at the iridocorneal angle. The implant may include an artificial lens, a limbal ring, and various means to anchor for the artificial lens.

DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM

A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.

A nano-gold rod regional modification of artificial lens and its preparation and use

MALE URETHRAL PROSTHESIS WITH TENSIONING MEMBER

The present invention provides a urethral prosthesis including a first and a second arm that join to form a junction, and a stem that is also joined to the junction. The junction is adapted to exert sufficient pressure on a portion of a patient's urethra to prevent unintentional voiding of the patient's bladder. However, upon exerting a tension force on the stem, the pressure exerted by the junction is reduced such that the patient's bladder may be intentionally voided.

DEVICE FOR AORTIC REPAIR AND METHOD OF USING THE SAME

A prosthetic component for repair of a patient's aorta includes an uncovered portion spanning the innominate arteries, and a graft material on a proximal end thereof.

ИНТРАОКУЛЯРНАЯ ЛИНЗА С НЕПРОНИЦАЕМОЙ ПОВЕРХНОСТЬЮ

MATERIALS FOR OPHTHALMI DEVICES WITH HIGH REFRACTIVE INDEX

Medical devices with reduced thrombogenicity

A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to attachment of proteins such as enzymes that inhibit thrombosis and anticoagulants such as heparin or heparin fragments, one can produce medical devices and other materials for use in vascular applications having a number of benefits including covalent attachment, not requiring intermediate linkers or chemistry; substrate independent - works on polymers, metals, ceramics, 3D shapes like stents, valves, etc.; bioactivity is retained; surface may retain greater bioactivity over time in vivo; Simultaneously supports endothelialisation; can be stored for long periods, following freeze drying, and retains effectiveness when rehydrated and; surface is able to bind many fibrinolytic enzymes such as streptokinase, urokinase, tPA, plasmin).

Medical devices with reduced thrombogenicity

A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to attachment of proteins such as enzymes that inhibit thrombosis and anticoagulants such as heparin or heparin fragments, one can produce medical devices and other materials for use in vascular applications having a number of benefits including covalent attachment, not requiring intermediate linkers or chemistry; substrate independent - works on polymers, metals, ceramics, 3D shapes like stents, valves, etc.; bioactivity is retained; surface may retain greater bioactivity over time in vivo; Simultaneously supports endothelialisation; can be stored for long periods, following freeze drying, and retains effectiveness when rehydrated and; surface is able to bind many fibrinolytic enzymes such as streptokinase, urokinase, tPA, plasmin).

IMPLANTS ASSEMBLED FROM SKELETAL POLYHEDRON UNIT CELLS, COILED UNIT CELLS OR MESH UNIT CELLS

Absorbable implants can be used to create volume and shape in soft tissues with regenerated tissue. The implants comprise lattices formed from multiple unit cells. Unit cells can be coils or springs, skeletal polyhedrons, foams, or structures derived from mesh and fiber. The implants may be coated or filled with cells and tissues, and preferably with autologous fat graft. The implants are particularly suitable for use in plastic surgery procedures, for example, to regenerate or augment breast tissue following mastectomy or in mastopexy procedures, and can provide an alternative to the use of permanent breast implants in these procedures.

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

LENS FOR USE IN A HUMAN OR ANIMAL BODY, AND PRODUCTION METHODS THEREOF

Use of self-assembling polypeptides as tissue adhesives

The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.

ENDOPROSTHESIS HAVING ALIGNED LEGS FOR EASE OF CANNULATION

The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and a plurality of leg portions, wherein the legs are in an aligned configuration for ease of cannulation. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also taught.

МОЧЕТОЧНИКОВЫЙ СТЕНТ

Endoprosthesis having aligned legs for ease of cannulation

The present disclosure is directed to a branched endoprosthesis comprising: a stent graft having a graft component and at least one support component together defining a body portion, a first leg portion, and a second leg portion; and a removable restraint extending along an exterior surface of the stent graft and being releasably attached between an exterior surface of the first leg portion and an exterior surface of the second leg portion and maintaining alignment of the first leg portion with the second leg portion to assist in cannulation of the second leg portion. 9120169_1 (GHMatters) P97547.AU.1 r4m d~ U- ...

MEDICAL DEVICES WITH REDUCED THROMBOGENICITY

A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to attachment of proteins such as enzymes that inhibit thrombosis and anticoagulants such as heparin or heparin fragments, one can produce medical devices and other materials for use in vascular applications having a number of benefits including covalent attachment, not requiring intermediate linkers or chemistry; substrate independent - works on polymers, metals, ceramics, 3D shapes like stents, valves, etc.; bioactivity is retained; surface may retain greater bioactivity over time in vivo; Simultaneously supports endothelialisation; can be stored for long periods, following freeze drying, and retains effectiveness when rehydrated and; surface is able to bind many fibrinolytic enzymes such as streptokinase, urokinase, tPA, plasmin).

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

A device and method for endovascular repair of a patient's aorta is disclosed. The device includes a frame component that has a balloon-expandable frame and a self-expanding frame secured to the balloon-expandable frame. The device also includes a valve element positioned at the proximal end of the frame component. The device may include another prosthetic component that may be secured to the frame component. The prosthetic component may include at least one conduit configured to receive a covered stent.

GRAFT ANCHOR SYSTEM AND METHOD

A graft anchor (100) has first and second arms (102a, 102b) each having a leading end (108a, 108b), a trailing end (106a, 106b), an inner surface (110a), and an outer bone contactable surface (112a, 112b). The graft anchor also has a resilient bridge (104) extending between the inner surface of the first arm and the inner surface of the second arm to space apart the first arm and the second arm. The resilient bridge defines a graft receiving pathway between the inner surfaces of the first and second arms. The resilient bridge also defines a deflection point about which a force acting upon the resilient bridge in a direction from the leading end to the trailing end causes the leading ends of the first and second arms to move toward one another and the trailing ends of the first and second arms to move away from one another.

PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

Intraocular lens with proofed surface

COMPOSITE MATERIAL BONE IMPLANT

Radiolucent composite implants. Some embodiments include reconfiguration indicators. Some embodiments include radio-opaque markers, especially along contours. Some embodiments are provided in kit form with accessories such as radiolucent drill guides and/or drives. Some embodiments have fiber reinforcement adapted for various usage scenarios. Some embodiments include metal components, for example, to increase strength. Also described are manufacturing methods.

ВЕЩЕСТВА С ВЫСОКИМ ПОКАЗАТЕЛЕМ ПРЕЛОМЛЕНИЯ ДЛЯ ОФТАЛЬМОЛОГИЧЕСКИХ УСТРОЙСТВ

... 1. Материал для офтальмологических устройств, включающий: ! а) образующие устройство мономеры, по существу включающие один мономер, способный к полимеризации, имеющий следующую структуру: ! ! (I) ! где Z представляет собой Н или СН3; ! Х представляет собой (СН2)m или О(СН2СН2О)n; ! m составляет 2-6; ! n составляет 1-6; а ! Ar представляет собой фенил, который может быть незамещенным или замещенным заместителями, представляющими собой СН3, С2Н5, н-С3Н7, изо-С3Н7, ОСН3, С6Н11, Cl, Br, С6Н5 или СН2С6Н5; ! б) способный к полимеризации сшивающий агент; и ! в) не способное к полимеризации блок-сополимерное поверхностно-активное вещество, выбираемое из группы, состоящей из пропиленоксид-этиленоксид-пропиленоксид блок-сополимерного поверхностно-активного вещества со средней молекулярной массой приблизительно 3600 и содержанием этиленоксидных звеньев приблизительно 40 вес.%, и этиленоксид-пропиленоксид-этиленоксид блок-сополимерного поверхностно-активного вещества со средней молекулярной массой ...

ДОЛГОВЕЧНЫЙ МНОГОСЛОЙНЫЙ ВЫСОКОПРОЧНЫЙ ПОЛИМЕРНЫЙ КОМПОЗИТ, ПОДХОДЯЩИЙ ДЛЯ ИСПОЛЬЗОВАНИЯ В ИМПЛАНТАТЕ, И ИЗДЕЛИЯ, ИЗГОТОВЛЕННЫЕ ИЗ НЕГО

... 1. Имплантируемое изделие для регулирования направления кровотока у пациента-человека, содержащее:створку, имеющую толщину и изготовленную из композитного материала, включающего более, чем один фторполимерный слой, имеющий множество пор и эластомер, присутствующий, по существу, во всех порах более чем одного фторполимерного слоя, при этом створка характеризуется соотношением между толщиной створки (мкм) и количеством слоев фторполимера, меньшим, чем приблизительно 5.2. Изделие по п. 1, в котором соотношение между толщиной створки (мкм) и количеством слоев фторполимера является меньшим, чем приблизительно 3, предпочтительно меньшим, чем приблизительно 1, более предпочтительно меньшим, чем приблизительно 0,5.3. Изделие по п. 1, в котором створка включает в себя, по меньшей мере, 10 слоев и композитный материал, содержащий менее чем приблизительно 50% (масс.) фторполимера.4. Изделие по п. 3, в котором створка имеет толщину, меньшую, чем 100 мкм.5. Изделие по п. 4, в котором створка характеризуется ...

Transcatheter valve prosthesis having an external skirt for sealing and preventing paravalvular leakage

A transcatheter valve prosthesis including a tubular stent includes an interior skirt or skirt portion is coupled to and covers an inner circumferential surface of the stent, and an exterior skirt or skirt portion is coupled to and covers an outer circumferential surface of the stent. A prosthetic valve component is disposed within and secured to the interior skirt or skirt portion. The interior and exterior skirts or skirt portions may overlap to form a double layer of skirt material on the stent, or may be portions of a skirt that do not overlap such that only a single layer of skirt material covers the stent. When the stent is in at least the compressed configuration, at least one endmost crown may be positioned radially inwards with respect to the remaining endmost crowns formed at the inflow end of the stent in order to accommodate the exterior skirt.

Hair implants comprising enhanced anchoring and medical safety features

A hair implant suitable for subcutaneous implantation is provided having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body and an external surface feature of the anchor body. The anchor further comprises at least one hair strand projecting from a distal end of the anchor body, wherein the at least one collagen receiving structure is configured to support collagen ligature growth after subcutaneous implantation of the hair implant to anchor the anchor to a hair implant recipient, and the collagen receiving structure is free of hair. A fracture line in the anchor body allows the body to fragment, thereby releasing collagen ligatures and allowing the implant fragments to "release" and fall out of the skin. The at least one hair strand may comprise a primary hair element with emerging hair elements.

HYDROGEL IMPLANT ARTICLE AND METHOD

DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM

MEDICAL DEVICES WITH REDUCED THROMBOGENICITY

A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to attachment of proteins such as enzymes that inhibit thrombosis and anticoagulants such as heparin or heparin fragments, one can produce medical devices and other materials for use in vascular applications having a number of benefits including covalent attachment, not requiring intermediate linkers or chemistry; substrate independent - works on polymers, metals, ceramics, 3D shapes like stents, valves, etc.; bioactivity is retained; surface may retain greater bioactivity over time in vivo; Simultaneously supports endothelialisation; can be stored for long periods, following freeze drying, and retains effectiveness when rehydrated and; surface is able to bind many fibrinolytic enzymes such as streptokinase, urokinase, tPA, plasmin).

IMPLANTABLE BONE AUGMENT AND METHOD FOR MANUFACTURING AN IMPLANTABLE BONE AUGMENT

Method for manufacturing an implantable bone augment arranged to at least partially fit in a bone defect in a bone of a patient, wherein the method comprises the steps of: - providing a three-dimensional model of at least a part of the bone of the patient comprising the bone defect; - designing the shape and size of an augment based on the three-dimensional model, wherein a bone contacting surface of the augment is formed complementary to a corresponding outer surface of the bone, in particular a surface of the bone defect; - designing the body of the augment having the designed shape and size and having a porous microstructure, wherein the step of designing further comprises providing reinforcements in said body based on predicted loading conditions of the implanted augment, and; - manufacturing the designed augment.

Composite aortic arch reconstruction system and using method thereof

Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods

A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes opposing first and second ends. Multiple portions form the first end of the body and part of a remainder of the body between the first and second ends. The first and second ends are wider than the remainder of the body. The multiple portions of the body are separated by empty space such that the multiple portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end of the body. The second end of the body is integral with the remainder of the body and not divided into multiple separated portions.

HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS

High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a single aryl hydrophobic monomer as a device forming monomer. In addition, the copolymers comprise a non-polymerizable block copolymer surfactant. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures.

Biodegradable endoprostheses and methods for their fabrication

Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

IMPLANTABLE VEIN FRAME

Verwendung selbst-assemblierender Polypeptide als Gewebekleber

Brustsiliconimplantat, das mit einem rekombinanten Spinnenseidenpolypeptid beschichtet ist, welches zwischen 8 und 48 identische repetitive Einheiten umfasst, wobei die repetitiven Einheiten unabhängig ausgewählt sind aus Modul C bestehend aus einer Aminosäuresequenz gemäß SEQ ID NO: 21 und einer Variante des Moduls C, die eine Sequenzidentität von mindestens 90% über die gesamte Länge der SEQ ID NO: 21 aufweist.

High refractive index ophthalmic device materials

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

Heart valve prosthesis

Liquefaction of bone matrix

The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.

IMPLANT WITH FIDUCIAL MARKERS

An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.

HYDROGEL IMPLANT ARTICLE AND METHOD

A hydrogel implant article of significant softness, pliability and elasticity when dry as well as when wet consists of a random cross-linked copolymer of 2-hydroxyethyl acrylate and an alkyl acrylate. The acrylate hydrogel article is useful, in one instance, as the material to produce a scleral buckle in retinal detachment surgery.

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM

A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material incudes at least one porous expanded fluoropolymer layer and an elastomeric material substantially filling substantially all of the pores of the porous expanded fluoropolymer.

HEART VALVES WITH INCREASED EFFECTIVE ORIFICE AREA

A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.

LIQUEFACTION OF BONE MATRIX

The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.

Methods and apparatus to enhance oxygen concentrations for advanced ophthalmic devices

Methods and apparatus to enhance levels of oxygen in tear fluid under a worn advanced contact lens are described. The advanced contact lens may include an insert which is impermeable to fluid flow across its body. The method of enhancement may include creating pores through the insert, creating channels in portions of the contact lens body, including layers of absorptive material, including devices to generate or release oxygen or means of moving tear fluid under the contact lens.

Placental tissue grafts

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located on top of and within the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high levels of laminin-5, a cell adhesion bio-active factor shown to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

SCLERAL PROSTHESIS FOR TREATING PRESBYOPIA AND OTHER EYE DISORDERS AND RELATED DEVICES AND METHODS

A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes (i) opposing first and second ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the ends. The first and second ends are wider than the remainder of the body. The first portions of the body are separated lengthwise along the body by empty space such that the first portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end. The scleral prosthesis also includes an insert configured to be placed and retained between the first portions of the body. The insert has a length that is at least about half of a length of the elongated body.

Joint replacement component with integrated fixation pads

In one embodiment, a prosthetic component includes a plurality of fixation pads coupled to a body portion. The fixation pads may be formed of a first material suitable for attachment to bone, and the body portion may be formed of a second material different from the first material and suitable to provide a bearing surface for a joint.

Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods

A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The elongated body includes (i) opposing first and second ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the ends. The first and second ends are wider than the remainder of the body. The first portions of the body are separated lengthwise along the body by empty space such that the first portions meet at a point between the first and second ends of the body and are not connected to each other between that point and the first end. The scleral prosthesis also includes an insert configured to be placed and retained between the first portions of the body. The insert has a length that is at least about half of a length of the elongated body.

SCLERAL PROSTHESIS FOR TREATING PRESBYOPIA AND OTHER EYE DISORDERS AND RELATED DEVICES AND METHODS

A scleral prosthesis includes an elongated body configured to be implanted into scleral tissue of an eye. The body includes (i) opposing first and second free ends and (ii) multiple first portions that form the first end of the body and part of a remainder of the body between the ends. The first portions are separated along at least about half of a total length of the body by empty space such that the first portions meet at a point between the ends and are not connected to each other between that point and the first end. The ends are wider than the remainder. The scleral prosthesis also includes an insert configured to be placed between the first portions and to substantially fill the empty space. The body includes a convex upper surface extending lengthwise between the ends. The insert includes a convex upper surface extending lengthwise along the insert.

Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom

A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.

Graft anchor system and method

A graft anchor (100) has first and second arms (102a, 102b) each having a leading end (108a, 108b), a trailing end (106a, 106b), an inner surface (110a), and an outer bone contactable surface (112a, 112b). The graft anchor also has a resilient bridge (104) extending between the inner surface of the first arm and the inner surface of the second arm to space apart the first arm and the second arm. The resilient bridge defines a graft receiving pathway between the inner surfaces of the first and second arms. The resilient bridge also defines a deflection point about which a force acting upon the resilient bridge in a direction from the leading end to the trailing end causes the leading ends of the first and second arms to move toward one another and the trailing ends of the first and second arms to move away from one another.

GRAFT ANCHOR SYSTEM AND METHOD

A graft anchor has first and second arms each having a leading end, a trailing end, an inner surface, and an outer bone contactable surface. The graft anchor also has a resilient bridge extending between the inner surface of the first arm and the inner surface of the second arm to space apart the first arm and the second arm. The resilient bridge defines a graft receiving pathway between the inner surfaces of the first and second arms. The resilient bridge also defines a deflection point about which a force acting upon the resilient bridge in a direction from the leading end to the trailing end causes the leading ends of the first and second arms to move toward one another and the trailing ends of the first and second arms to move away from one another.

HAIR IMPLANTS COMPRISING ENHANCED ANCHORING AND MEDICAL SAFETY FEATURES

A hair implant suitable for subcutaneous implantation is provided having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body and an external surface feature of the anchor body. The anchor further comprises at least one hair strand projecting from a distal end of the anchor body, wherein the at least one collagen receiving structure is configured to support collagen ligature growth after subcutaneous implantation of the hair implant to anchor the anchor to a hair implant recipient, and the collagen receiving structure is free of hair. A fracture line in the anchor body allows the body to fragment, thereby releasing collagen ligatures and allowing the implant fragments to "release" and fall out of the skin. The at least one hair strand may comprise a primary hair element with emerging hair elements.

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

A heart valve replacement device for endovascular repair is provided. The heart valve replacement device includes a plurality of fibers for creating a seal with an anatomy of the patient. A heart valve is carried by an inner graft covering.

GRAFT ANCHOR SYSTEM AND METHOD

A graft anchor (100) has first and second arms (102a, 102b) each having a leading end (108a, 108b), a trailing end (106a, 106b), an inner surface (110a), and an outer bone contactable surface (112a, 112b). The graft anchor also has a resilient bridge (104) extending between the inner surface of the first arm and the inner surface of the second arm to space apart the first arm and the second arm. The resilient bridge defines a graft receiving pathway between the inner surfaces of the first and second arms. The resilient bridge also defines a deflection point about which a force acting upon the resilient bridge in a direction from the leading end to the trailing end causes the leading ends of the first and second arms to move toward one another and the trailing ends of the first and second arms to move away from one another.

DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM

A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.

IMPLANTS ASSEMBLED FROM SKELETAL POLYHEDRON UNIT CELLS, COILED UNIT CELLS OR MESH UNIT CELLS

Absorbable implants can be used to create volume and shape in soft tissues with regenerated tissue. The implants comprise lattices formed from multiple unit cells. Unit cells can be coils or springs, skeletal polyhedrons, foams, or structures derived from mesh and fiber. The implants may be coated or filled with cells and tissues, and preferably with autologous fat graft. The implants are particularly suitable for use in plastic surgery procedures, for example, to regenerate or augment breast tissue following mastectomy or in mastopexy procedures, and can provide an alternative to the use of permanent breast implants in these procedures.

Segmented scaffold designs

Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end is provided. The assembly includes, at its first end, a first vascular prosthesis portion, and at its second end, a second vascular prosthesis portion which has only a prosthesis material. The vascular prosthesis assembly has a stent portion which is provided between the first vascular prosthesis portion and the second vascular prosthesis portion, the stent portion being free of prosthesis material to allow fluid flow therethrough and received within the aortic arch and spanning the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient.

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

MEDICAL DEVICES WITH SEALING PROPERTIES

The present disclosure relates to a medical device and methods of using the same. In embodiments, the medical device may be a buttress formed of nucleophilic buttress components and electrophilic buttress components which react to both form the buttress and provide the buttress with self-sealing capabilities after a staple or some other fixation device is placed therethrough, thereby enhancing its hemostatic properties. In other embodiments, the medical device is a hernia patch formed of a fibrous substrate, nucleophilic precursor components and electrophilic precursor components.

HEART VALVES WITH INCREASED EFFECTIVE ORIFICE AREA

A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

A device and method for endovascular repair of a patient's aorta is disclosed. The device includes a frame component that has a balloon-expandable frame and a self-expanding frame secured to the balloon-expandable frame. The device also includes a valve element positioned at the proximal end of the frame component. The device may include another prosthetic component that may be secured to the frame component. The prosthetic component may include at least one conduit configured to receive a covered stent.

TRANSCATHETER VALVE REPAIR HAVING IMPROVED PARAVALVULAR SEAL

A transcatheter valve assembly replacement device includes a paravalvular seal that includes outwardly extending fibers that create a seal with the annulus when the valve assembly is deployed.

Placental tissue grafts and methods of preparing and using the same

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

Placental tissue grafts

Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

Systems, devices, and methods for sub-urethral support

Disclosed are single-incision surgical procedures for treatment of urinary incontinence and/or pelvic floor disorders and related uses, devices, kits, and methods. Implants are also disclosed for use in the exemplary procedures. In certain embodiments, soft tissue anchors are used to anchor the surgical implants to obturator membranes of a patient.

Methods to improve adhesion of polymer coatings over stents

Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.

Molds used to produce pva hydrogel implants and related implants

Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.

Method for fusing a human or animal joint as well as fusion device and tool set for carrying out the method

The fusion device for fusing a synovial joint of a human or animal patient, in particular a human facet joint, finger joint or toe joint, includes two pin-shaped anchorage portions ( 1 ) and arranged therebetween a stabilization portion ( 2 ). The anchorage portions ( 1 ) include a thermoplastic material which is liquefiable by mechanical vibration. The stabilization portion ( 2 ) preferably has a surface which is equipped for enhancing osseointegration. The anchorage portions ( 1 ) have a greater thickness (T 1 ) and a greater depth (D) than the stabilization portion ( 2 ). Then the fusion device is pushed between the articular surfaces and mechanical vibration, in particular ultrasonic vibration, is applied to the proximal face ( 4 ) of the fusion device. Thereby the liquefiable material is liquefied where in contact with the bone tissue and penetrates into the bone tissue, where after re-solidification it constitutes a positive fit connection between the fusion device and the bone tissue.

Fracture fixation systems

Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days. The disclosed putties create an osteoconductive scaffold for bone regeneration and degrade over time to harmless 5 resorbable byproducts. Fixation devices for contacting an endosteal wall of an intramedullary (IM) canal of a fractured bone are also disclosed. One such fixation device includes a woven elongated structure fabricated from resorbable polymer filaments. The woven elongated structure has resilient properties that allow the woven 10 structure to be radially compressed and delivered to the IM canal using an insertion tube. When the insertion tube is removed, the woven structure expands towards its relaxed cross-sectional width to engage the endosteal wall. The woven elongated structure is impregnated with a resorbable polymer resin that cures in situ, or in the IM canal.

Intravitreous self adaptive stent

Disclosed herein are devices, methods and kits for a stent for treating an eye, comprising a flexible material, wherein the stent is self adaptive to a dimension of a vitreous cavity in the eye.

Devices and methods for treating defects in the tissue of a living being

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.

Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

Stentless Support Structure

A stentless support structure capable of being at least partly assembled in situ. The support structure comprises a braided tube that is very flexible and, when elongated, becomes very long and very small in diameter, thereby being capable of placement within a small diameter catheter. The support structure is preferably constructed of one or more thin strands of a super-elastic or shape memory material such as Nitinol. When released from the catheter, the support structure folds itself into a longitudinally compact configuration. The support structure thus gains significant strength as the number of folds increase. This radial strength obviates the need for a support stent. The support structure may include attachment points for a prosthetic valve.

Method for inserting an artificial implant between two adjacent vertebrae along a coronal plane

A method for inserting an artificial implant between two adjacent vertebrae along a corona plane,

Hydrogel jacketed stents

Hydrogel jacketed stents provide the ability to fill in the stent frame in vivo to at least partially cover the interior of the surface of the stent following deployment while having the convenience of attaching the jacket to the exterior of the stent. The hydrogel can be pleated and/or folder over the exterior of the stent to provide for extension of the stent without damaging the hydrogel. The hydrogel sheet can be secured at one or more points along the circumference to associate the sheet of hydrogel with the exterior surface of the stent frame. The stent can be conveniently delivered using similar technology as conventional stents if desired. The hydrogel can provide for drug delivery if desired.

Semi-biological intervertebral disc replacement system

Disclosed is a system and method for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue

Selectively Expanding Spine Cage, Hydraulically Controllable In Three Dimensions for Vertebral Body Replacement

A selectively expanding spine cage has a minimized diameter in its unexpanded state that is smaller than the diameter of the neuroforamen through which it passes in the distracted spine. The cage conformably engages between the endplates of vertebrae to effectively distract the anterior disc space, stabilize the motion segments, eliminate pathologic spine motion, or effect vertebral body replacement. Expanding selectively (anteriorly, along the vertical axis of the spine) rather than uniformly, the cage height increases and holds the vertebrae with fixation forces greater than adjacent bone and soft tissue failure forces in natural lordosis. Stability is thus achieved immediately, enabling patient function by eliminating painful motion. The cage shape intends to rest proximate to the anterior column cortices securing the desired spread and fixation, allowing for bone graft in, around, and through the implant for arthrodesis whereas for arthroplasty it fixes to endpoints but cushions the spine naturally.

Joint device and method

A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose. Further, a method of treating hip joint osteoarthritis in a human patient by providing an artificial hip joint surface using a mould is provided. The method comprises the steps of: said mould being placed inside of said hip joint, said mould being injected with a fluid adapted to harden, said fluid hardening inside of said hip joint, said mould being resorbed by the human body, and said hardened fluid serving as artificial hip joint surface.

Proximally Self-Locking Long Bone Prosthesis

A femoral stem hip implant for insertion into a surgically created aperture in a femur includes a monolithic femoral stem made of shape memory material. The stem is configured to be inserted into the aperture, has a proximal portion and a longitudinal axis. The shape memory material within the proximal portion has a cross-section perpendicular to the longitudinal axis. At least a portion of the shape memory material within the proximal portion is in a compressed state by application of a plurality of compressive forces at a temperature below an austenitic finish temperature of the shape memory material so that the cross-section expands through shape memory effect via the formation of austenite in response to a temperature increase after insertion into the aperture thereby causing a locking-force to be exerted against an inner surface of the aperture, the locking force being sufficient to stabilize the implant in the aperture.

Method for producing a small thin-walled tube from a magnesium alloy

The invention relates to a method for producing a small thin-walled tube for a medical application or for a medical product, in particular for a stent, wherein a blank of an in particular bioresorbable magnesium alloy is deformed to produce a small tube, after which the small tube is used for medical purposes or from which the medical product, such as a stent, can be made. In order to be able to produce the small tube in one step and with high precision, it is provided according to the invention that a male die ( 2 ) with a base body ( 3 ) and a mandrel ( 4 ) tapered relative to the base body ( 3 ) and the blank is provided with a blind hole or an opening, wherein a diameter of the blind hole or the opening of the blank is equal to or greater than an outer diameter of the mandrel ( 4 ), after which the blank with inserted mandrel ( 4 ) with the male die ( 2 ) is pressed forwards at least in part through a female die ( 5 ) with a receiving region ( 6 ) and a contouring region ( 7 ), wherein the contouring region ( 7 ) has a free diameter, which is larger than the outer diameter of the mandrel ( 4 ), but smaller than an outer diameter of the blank, in order to form the small tube.

Intraoperative and post-operative adjustment of an annuloplasty ring

An intraoperative adjustment device is described. In some embodiments, the device includes an elongate body including a proximal end and a distal end, the distal end configured to penetrate an outer surface of an adjustable cardiac implant implanted in a patient's heart, and the proximal end and the distal end connected by at least one energy-transfer member. In some embodiments, the distal end includes at least one electrode coupled to the energy-transfer member and configured to deliver an activation energy to the adjustable cardiac implant. In some embodiments, the proximal end is configured to attach to an energy source that provides the activation energy. In some embodiments, the proximal end is configured to be located outside the patient's body while the distal end is coupled to the adjustable cardiac implant that is implanted in the patient's heart.

Prostheses for spine discs having fusion capability

The present invention provides both a device and a method. The device is a human made replacement for the soft discs in the spine. A fabric pouch encloses a central hydraulic element made up of small soft beads. Two pouches with beads are implanted into a prepared disc space to function as an intervertebral disc. The method is conversion of the device into a fusion element.

Magnesium-Based Absorbable Implants

A bioabsorbable implant including an elongated metallic element comprising an alloy of more than about 70% by weight magnesium and about 2-20% by weight lithium, substantially free of rare earth metals. An implantable tissue filler includes a particulate material suspended in a carrier, comprising more than about 70% by weight magnesium and about 2-20% by weight lithium, substantially free of rare earth metals. A bioabsorbable implant includes an elongated metallic element having a core and at least two layers of alternating compositions of magnesium, iron, and alloys thereof. A bioabsorbable implant includes at least three wires including magnesium and defining a cylindrical sheath surrounding at least one core wire including iron. A bioabsorbable implant includes a plurality of intertwined magnesium alloy wires defining a strand, with an Fe-rich layer formed by vapor, chemical and/or electro-deposition defined on a surface of at least one of the wires.

Transluminal delivery system

There is disclosed herein a transluminal delivery system for a self-expanding luminal prosthesis, the system comprising an inner catheter component ( 30 ) and a retractable sheath ( 12 ) to surround the component thereby to define an annular space to receive the prosthesis ( 10 ), the component exhibiting an anti-sliding component, for abutting a luminal surface portion of the prosthesis ( 10 ) to restrain the prosthesis from sliding with the sheath ( 12 ), and relative to the inner catheter ( 30 ), while the sheath retracts relative to the prosthesis to release the prosthesis progressively into the target bodily lumen characterised in that the anti-sliding component is or includes at least one sleeve ( 36, 50, 66, 76 ) having a length direction parallel to the longitudinal axis of the annular space and having at least one bound portion ( 33, 52, 64, 65, 74 ) of its length that is not free to slide on the inner catheter, and at least one unbound portion of its length with a capability to slide axially on the inner catheter ( 30 ) and thereby to exhibit a radial swelling capability, to deliver an increase in the radial thickness of the sleeve ( 36, 50, 66, 76 ) while the sheath retracts. Associated methods are also disclosed.

Joint arthroplasty devices and surgical tools

Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Woven Prosthesis and Method for Manufacturing the Same

A woven prosthesis, such as a woven vascular graft, woven from warp and weft yarns. Velour warp yarns forming the prosthesis are selectively incorporated into a base layer of the prosthesis so as to provide a bulbous section without compromising the porosity of the prosthesis.

Method of Accessing the Left Common Carotid Artery

Single filter and multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a blood filtering system captures and removes particulates dislodged or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

Progenitor endothelial cell capturing with a drug eluting implantable medical device

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

STENT GRAFT WITH TWO LAYER ePTFE LAYER SYSTEM WITH HIGH PLASTICITY AND HIGH RIGIDITY

A vascular prosthesis and method are disclosed comprising a first flexible stent having a lattice structure with a compacted configuration and an expanded configuration, a second flexible stent inside the first flexible stent to form a tubular structure, a first film layer of graft material such as expanded polytetrafluoroethylene sandwiched between the first and second flexible stents, and a second film layer of expanded polytetrafluoroethylene sandwiched between the first and second flexible stents, the second layer having a higher rigidity and a lower plasticity than the first layer.

Biodegradable endoprostheses and methods for their fabrication

Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

System and devices for the repair of a vertebral disc defect

A system for repairing a vertebral disc defect, such as hernia or bulge, a full or partial tear in the annulus, or a weakened annulus wall as a result of an excision procedure. The system introduces a treatment device arranged to repair the defect, and may prevent the leakage of fluid from the nucleus. The components of the device may be resorbable materials, and may induce the ingrowth of cellular material into the components. The system may feature a locating device to ensure proper placement of the treatment device.

Implantable and lumen-supporting stents and related methods of manufacture and use

An implantable medical stent system, including a radially expandable stent including a filamental structure in a pattern surrounding a bore to form a substantially tubular wall along a length relative to a longitudinal axis; wherein the filamental structure includes at least one actuate crown with a crown peak having a radius of curvature located along a reference axis, and first and second arcuate crown shoulders on first and second sides, respectively, of the reference axis; and wherein the filamental structure also includes at least one pair of adjacent first and second elongated struts extending from the first and second crown shoulders, respectively.

Adjustable annuloplasty ring with subcutaneous activation port

Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.

Stentless Support Structure

A stentless support structure capable of being at least partly assembled in situ. The support structure comprises a braided tube that is very flexible and, when elongated, becomes very long and very small in diameter, thereby being capable of placement within a small diameter catheter. The support structure is preferably constructed of one or more thin strands of a super-elastic or shape memory material such as Nitinol. When released from the catheter, the support structure folds itself into a longitudinally compact configuration. The support structure thus gains significant strength as the number of folds increase. This radial strength obviates the need for a support stent. The support structure may include attachment points for a prosthetic valve.

Adjustable annuloplasty ring and activation system

An adjustable annuloplasty device is described. In some embodiments, the device includes a body member having a surface that conforms at least partially to a cardiac valve annulus. The body member comprises a shape-memory member that transforms from a first configuration to a second configuration in response to an applied energy. In some embodiments, the device further includes a first electrode assembly, coupled to the shape-memory member, that transfers energy to the shape-memory member, and a second electrode assembly, coupled to the shape-memory member, that transfers at least a portion of the energy away from the shape-memory member.

System for treatment of plantar fasciitis

An stretch resistant plantar fascia support system is provided. The stretch resistant plantar fascia support system is adhesively applied to the foot of a patient for providing relief from plantar fasciitis. A portion of the stretch resistant plantar fascia support system is adhesively attached to the bottom surface of the foot for reducing stress on the plantar fascia.

Inflatable multi-chambered devices and methods of treatment using the same

Inflatable multi-chambered devices are provided for repairing or replacing spinal discs and distracting neighboring vertebral elements. Also included are cushioning devices that may be used in a joint replacement device cushioning system. Further included are kits and systems that include such devices, methods for making such devices, and methods of treating patients in need of such devices. Examples further include cosmetic augmentation and restoration devices.

Stent fabrication via tubular casting processes

Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

Implant with a visual indicator of a barrier layer

An implantable soft tissue prosthesis device comprising a silicone elastomer-shell filled with silicone gel or liquid, which among the layers that constitute its shell includes a barrier layer formed of a low permeability silicone, which impedes the bleeding or diffusion of the silicone gel from the inside of the implant to its surroundings through the shell. This barrier layer is given a coloration different to the other layers of the shell, making it visible in the finished product. The coloration of the barrier layer gives the fabricator of the implant as well as to medical personnel, the possibility to identify the presence of the barrier layer and its homogeneity, improving the safety of the device.

Non-Axisymmetric Aortic Valve Devices

The present disclosure provides aortic valve prosthetic devices that are constructed in a non-axisymmetric shape, or are expandable to a non-axisymmetric shape for improved results in the repair of defective aortic valves. The devices can be surgically implanted, or they can be implanted percutaneously through an insertion catheter. The expandable devices can be self-expanding or expanded by an inflatable balloon to a non-axisymmetric cross-section geometry.

Device And A Method For Augmenting Heart Function

A device, a kit and a method are presented for permanently augmenting the pump function of the left heart. The basis for the presented innovation is an augmentation of the physiologically up and down movement of the mitral valve during each heart cycle. By means of catheter technique, minimal surgery, or open heart surgery implants are inserted into the left ventricle, the mitral valve annulus, the left atrium and adjacent tissue in order to augment the natural up and down movement of the mitral valve and thereby increasing the left ventricular diastolic filling and the piston effect of the closed mitral valve when moving towards the apex of said heart in systole and/or away from said apex in diastole.

Method and apparatus for the treatment of tissue

This disclosure presents methods and devices for treating a defect in soft tissue of a patient. The methods and devices can employ fixation delivery apparatuses and fixation apparatuses positioned, at least in part, in or on the soft tissue to be repaired. In some aspects, these techniques include the use of this includes a fixation apparatus that includes at least one bone anchor connected to at least one tissue anchor by a shortenable elongate member.

Intraluminal scaffold system and use thereof

Intraluminal scaffold assembly implantable in a body lumen of a patient to manipulate a valve of the lumen is provided. The intraluminal scaffold assembly includes an intraluminal scaffold, an elongated core member coupled with the intraluminal scaffold having a length sufficient to traverse a valve in a body lumen with the intraluminal scaffold positioned proximate the valve. The intraluminal scaffold assembly can further include one or more additional intraluminal scaffolds, a weighted element or an active element that is coupled with the elongated core member. A system including a delivery system and the intraluminal scaffold assembly, as well as methods of delivering the intraluminal scaffold assembly and using the intraluminal scaffold assembly to manipulate a valve in a body lumen, is also provided.

Flexible intraluminal scaffold

Expandable intraluminal scaffold defining a longitudinal axis is provided, wherein the scaffold includes at least two filaments extending from a head portion disposed along the longitudinal axis at a first longitudinal end, each of the at least two filaments including a free end portion at a second longitudinal end opposite the head portion. The at least two filaments converge toward each other at a juncture disposed proximate the longitudinal axis between the first longitudinal end and the second longitudinal end. A system including a delivery system and the intraluminal scaffold, as well as a method of delivering the scaffold, is also provided.

Graft Devices and Methods of Use

A tubular graft device is provided comprising a tubular member and a fiber matrix of one or more polymers about a circumference of the tubular member. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft and connecting the graft between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.

Fecal incontinence device, system and method

A device for treating fecal incontinence in a subject is provided. The device includes a plug configured for positioning mostly within an anal canal of the subject.

Biodegradable Drug Eluting stent Pattern

In embodiment, pattern for polymeric radially expandable implantable medical devices such as stents for implantation into a bodily lumen are disclosed.

Thoracic aorta stent graft

A stent graft for placement in the thoracic arch of a patient has a tubular body defining a main lumen therethrough, a plurality of zig zag stents along the tubular body, each of the stents comprising a plurality of struts and bends, the bends being between adjacent struts. At least a first stent and an adjacent second stent having at least a pair of adjacent bends on the first stent aligned with an adjacent pair of bends on the second stent, whereby a first pair of adjacent struts of the first stent and a second pair of adjacent struts of the second adjacent stent together define a diamond shape region. A recess is within the diamond shaped region with the recess extending into the lumen of the tubular body. A fenestration extending into the tubular body within the recess in the diamond shaped region and a graft tube leading from the fenestration into the main lumen. There can be one, two or three diamond shaped regions, recesses, fenestrations and graft tubes Proximally of the or each diamond shaped region the tubular body has a first diameter, distally of the diamond shaped region the tubular body has a second diameter and in the region of the tubular body around the diamond shaped region the tubular body has a third diameter, the first diameter being greater than the second diameter and both the first and second diameter being greater than the third diameter whereby a central region is defined which will allow circumferential blood flow during an operation out of the graft tube into the recess and then into the central region.

Bioabsorbable stent

A bioabsorbable stent has a relatively high radial force and can be placed directly at the lesion without the possibility or reducing the possibility of occluding the lesion again after placement. The bioabsorbable stent is formed from a mixture composed of a bioabsorbable aliphatic polyester and an aromatic compound having one or more aromatic rings.

Annuloplasty Ring with Piercing Wire and Segmented Wire Lumen

An annuloplasty device having an expandable member, a plurality of lobes, and a piercing wire is herein disclosed. In some embodiments, the lobes extend radially outwardly from the expandable member. The lobes each have a wire lumen disposed therethrough, and the piercing wire is extendable through the wire lumen of each lobe to secure the device to adjacent heart tissue. In some embodiments, the expandable member comprises an inflatable medical balloon. In addition, a method of implanting an annuloplasty device is disclosed.

Artificial Disc Device

An artificial disc device for replacing a damaged nucleus is disclosed. In one form, the device may be inserted in components such that the device may be assembled within and retained by the natural annulus therein. In another form, the device may be inserted into the natural annulus in a collapsed or compressed state or arrangement and then be expanded within and retained by the annulus therein. In a further form, the device may be provided with a releasable connection so that the device may be connected in an insertion configuration and may be released in an operable configuration. Insertion tools and methods are also disclosed.

In-situ intervertebral fusion device and method

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

Seal for an ostomy appliance

The present invention relates to a sealing wafer ( 1 ) adapted to be arranged in a stoma receiving hole ( 5 ) of a base plate ( 2 ) comprising an attachment platform extending from an outer edge adapted to be attached to the base plate towards an inner edge defining a through-going hole ( 17 ) for receiving a stoma, the sealing wafer further comprising at least a first urging part extending transversely from the proximal surface facing towards the user during use of the attachment platform and wherein the first urging part is resilient in the direction transverse to the proximal surface. This provides a sealing wafer which is particularly suitable for use with a stoma around which the skin has an uneven curvature, such as a retracted stoma wherein the stoma has pulled back resulting in a crater-like area.

Low profile intervertebral implant

The present invention is directed to a low profile intervertebral implant ( 10 ) for implantation in an intervertebral disc space (D) in-between adjacent vertebral bodies (V). The intervertebral implant includes a plate ( 40 ) preferably coupled to a spacer ( 20 ). The plate is preferably formed from a first material and the spacer is preferably formed from a second material, the first material being different from the second material. The plate is preferably sized and configured so that the plate does not extend beyond the perimeter of the spacer. In this manner, the plate preferably does not increase the height profile (hs) of the spacer and the plate may be implanted within the intervertebral disc space in conjunction with the spacer.

Methods of making medical devices

Scaffold-supported metal or pseudometallic film covers suitable for use as medical devices are disclosed together with methods of fabricating the devices. Methods for making the medical devices consist of either providing or forming a scaffold, then depositing a metallic or pseudometallic film cover onto the scaffold in such a manner as to form an integral, substantially monolithic junction between the deposited cover material and the scaffold.

Tissue prosthesis and method of, and equipment for, forming a tissue prosthesis

A tissue prosthesis 100 comprises an envelope 38 of a biologically inert, elastically deformable material capable of being expanded to conform to an interior surface of a cavity 36 formed at a site 10 in a patient's body. A filler material 60 is received in a fluent state in the envelope 38. The filler material 60 is of the same class of material as the envelope 38 to form, when cured, together with the envelope 38, a unified structure.

Stretchable stent and delivery

An implant delivery catheter enables permanent modification of the implant length in the vicinity of the treatment site prior to radial expansion thereof. The implant is releasable carried between inner and outer tubular members of the delivery catheter which, upon repositioning relative to one another using an actuator mechanism, impart any of tensile, compressile or torquing forces to the implant causing permanent modification of the implant length. In one embodiment, the circumference of the implant is substantially similar both before and after modification of the implant length. In another embodiment, the implant includes a plurality of strut sections interconnected by bridges which are capable of the deformation along the longitudinal axis of the implant.

Heart valve repair devices and methods

Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the first section and positioning the second section on an opposite side of the heart valve. The first section may be turned in a manner such that the chords move closer to the center of the first section. The first section draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing.

Dynamic knee balancer with pressure sensing

A device for performing a surgical procedure on a knee includes an adjustable femoral portion, a tibial portion and at least one sensor coupled with the femoral and/or tibial portions to sense pressure exerted by the femoral and tibial portions against one another. The femoral portion is adapted for removably coupling with a distal end of a femur to adjust tension in soft tissue adjacent the knee and has at least one positioning feature adapted to move relative to the distal end of the femur as the femoral portion is adjusted, thus helping position a femoral prosthetic on the distal end of the femur. The sensor(s) may be adapted to sense pressure at medial and lateral sides of the knee, and relative pressures may be displayed as data on a visual display. Adjustments to the femoral member may be made to balance pressure at flexion and extension of the knee.

Method for fabricating medical devices with porous polymeric structures

Medical articles with porous polymeric structures and methods of forming thereof are disclosed. The porous structure can have pores sizes that are nanoporous or greater than nanoporous. The porous structure can be a coating or layer of a medical device such as a stent, stent graft, catheter, or lead for pacemakers or implantable cardioverter defibrillators. Additionally, the body of the medical device can be a porous polymeric structure. The porous structure can be made from bioabsorbable polymers. The porous structures can be formed by contacting a polymer with a supercritical fluid.

Adjustable implant and method of use

A system includes an adjustable implant configured for implantation internally within a subject and includes a permanent magnet configured for rotation about an axis of rotation, the permanent magnet operatively coupled to a drive transmission configured to alter a dimension of the adjustable implant. The system includes an external adjustment device configured for placement on or adjacent to the skin of the subject having at least one magnet configured for rotation, the external adjustment device further comprising a motor configured to rotate the at least one magnet and an encoder. Rotation of the at least one magnet of the external adjustment device effectuates rotational movement of the permanent magnet of the adjustable implant and alters the dimension of the adjustable implant. Drive control circuitry is configured to receive an input signal from the encoder.

Surgical spreadable sheet delivery and positioning system and method

A prepackaged mesh unit which comprises a spreadable sheet, a guide rod configured for remotely positioning the spreadable sheet within a body cavity, and a plurality of self-extending elements collapsed with the spreadable sheet and held at one end by the guide rod, wherein the self-extending elements have an elastic property and store elastic energy while collapsed with the spreadable sheet, wherein the number and configuration of the self-extending elements is selected to match a size and shape of the spreadable sheet.

In vivo sensor and method of making same

Implantable in vivo sensors used to monitor physical, chemical or electrical parameters within a body. The in vivo sensors are integral with an implantable medical device and are responsive to externally or internally applied energy. Upon application of energy, the sensors undergo a phase change in at least part of the material of the device which is then detected external to the body by conventional techniques such as radiography, ultrasound imaging, magnetic resonance imaging, radio frequency imaging or the like. The in vivo sensors of the present invention may be employed to provide volumetric measurements, flow rate measurements, pressure measurements, electrical measurements, biochemical measurements, temperature, measurements, or measure the degree and type of deposits within the lumen of an endoluminal implant, such as a stent or other type of endoluminal conduit. The in vivo sensors may also be used therapeutically to modulate mechanical and/or physical properties of the endoluminal implant in response to the sensed or monitored parameter.

Branch vessel prostheses

The present embodiments provide a branch vessel prosthesis for placement at least partially between a main vessel and a branch vessel of a patient. The branch vessel prosthesis has a graft including a generally tubular body of a biocompatible material. At least one stent is coupled to a proximal region of the graft, and at least one stent is coupled to a distal region of the graft. The proximal region of the graft includes a generally straight configuration in an expanded deployed state that is substantially parallel to a longitudinal axis of a main vessel. The distal region of the graft includes a generally straight configuration in the expanded deployed state that is substantially parallel to a branch vessel. A curvature of a central region varies an angle in which the distal region of the graft is disposed relative to the proximal region.

Minimally-invasive method and apparatus for restructuring the retina

The present invention comprises an implant for placing inside the eye such that the implant comes into contact with the interior tissue of the eye such that it conforms to the inner globe geometry of the eye. Implants of the present invention may also be used to alter the focal length of the eye thereby providing a treatment method for the correction of myopia and hyperopia. The device may consist of several possible configurations, an open mesh structure, a solid metal ring, a solid polymer shape, a mesh polymer shape or combination of these. The shape may be a curve, a sphere, a ring or a combination thereof that are specifically shaped to approximate a desired portion of the interior globe of the eye in order to treat myopia or hyperopia.

Device and method for replacing mitral valve

A prosthetic mitral valve assembly is disclosed. The assembly comprises a radially-expandable stent including a lower portion sized for deployment between leaflets of a native mitral valve and an upper portion having a flared end. The upper portion is sized for deployment within the annulus of the mitral valve and the flared end is configured to extend above the annulus. The stent is formed with a substantially D-shape cross-section for conforming to the native mitral valve. The D-shape cross-section includes a substantially straight portion for extending along an anterior side of the native mitral valve and a substantially curved portion for extending along a posterior side of the native mitral valve. The assembly further includes a valve portion formed of pericardial tissue and mounted within an interior portion of the stent for occluding blood flow in one direction.

Arthrodesis implant

The invention relates to an implant ( 1 ) for osseous fusion between two bones, including a first portion ( 20 ) having a longitudinal axis A, for being inserted in the first bone and including a first means ( 24 ) for attaching said implant in said first bone, and a second portion ( 30 ) having a longitudinal axis B, for being inserted in the second bone and including a second means ( 34 ) for attaching said implant in said second bone, said first and second portions ( 20, 30 ) being connected by a central core ( 40 ), said central core being a solid body, the cross-section of which, in a plane perpendicular to said longitudinal axis A, has the shape of a star having at least three points ( 41, 42, 43 ), said first portion having three tabs ( 21, 22, 23 ), each tab extending along said longitudinal axis A from the free end ( 41 a, 42 a, 43 a ) of one of the points of said central core.

Medical Implants With Increased Hydrophilicity

Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.

Endoluminal prosthesis with steerable branch

An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. A second stent may be positioned adjacent to and distal of the first stent. An opening in the sidewall may be positioned longitudinally between a peak of the first stent and a valley of the second stent. A tubular branch may be disposed in the opening. The branch may include first and second end openings. The branch may be flexibly orientable between a retrograde configuration in which the first end opening is oriented toward the distal end and the second end opening is oriented toward the proximal end and an antegrade configuration in which the first end opening is oriented toward the proximal end and the second end opening is oriented toward the distal end.

Joint arthroplasty devices and surgical tools

Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Vascular Clamps for Vascular Repair

A magnetic vascular clamp for vascular repair is described. There is a vascular sleeve forming a flexible cylindrical bellows that cylindrically encloses a section of vascular tissue to allow freely movement of the enclosed vascular tissue within the vascular sleeve. A pair of sleeve anchor rings are at each end of the vascular sleeve and they form a fixed seal with underlying vascular tissue to minimize fluid leakage from within the vascular clamp.

Radially expandable polymer prosthesis and method of making same

Polymeric stents having fracture toughness and resistance to recoil after deployment are disclosed along with methods of manufacturing such stents. Improvements to mechanical characteristics and other improvements may be achieved by having polymer chains within individual stent struts oriented in a direction that is closer to or in line with the axis of the individual stent struts. The struts are connected to each other by hinge elements that are configured to bend during crimping and deployment of the stent. Ring struts form ring structures. A ring structure can have an overall curvilinear length from about 12 mm to about 15 mm.

Sac for use in spinal surgery

A method for fusing spinal bone is provided. The method comprises placing a sac between two or more adjacent sections of the spine to be fused, and filling the sac with bone tissue. The surfaces of the sac abutting the sections of the spine comprise porous material for allowing bone to grow between the spine and the sac. Surfaces of the sac not abutting the sections of the spine are nonporous to bodily fluids and thereby prevent premature deterioration of the bone tissue inside the sac. A sac for fusing spinal bone and a kit comprising the sac are also provided.

Medical device comprising an artificial contractile structure

A medical device including artificial contractile structures generally devised to be used in the medical field. Such structures may be advantageously used to assist the functioning of an organ. The medical device includes an artificial contractile structure having at least two contractile elements ( 100 ) adapted to contract an organ, in such way that each of the contractile elements ( 100 ) can be in a resting or in an activated position, independently of the position of each other, the activated position being defined with the contractile element ( 100 ) constricting the organ and the resting position being defined with the contractile element ( 100 ) not constricting the organ, and at least one actuator designed to activate the contractile structure. Each contractile element ( 100 ) is connected to an adjacent contractile element ( 100 ), while remaining flexible one with respect to the other.

Embolic protection devices and related systems and methods

According to one aspect of the disclosure, an embolic protection device is provided comprising an elongate element having a deflector at its distal end. The embolic protection device is generally configured to redirect and/or funnel embolic debris and permit at least a portion of the blood, no longer containing the redirected and/or funneled embolic debris, to perfuse the surrounding vasculature and/or tissue.

Artificial Hemi-Lumbar Interbody Spinal Fusion Cage Having an Asymmetrical Leading End

An artificial interbody spinal implant adapted for placement across an intervertebral space formed across the height of a disc space between two adjacent vertebral bodies is disclosed. The implant has an asymmetrical leading end adapted to sit upon the more peripheral areas, such as the apophyseal rim and the apophyseal rim area, of the vertebral end plate region of the vertebral bodies without protruding therefrom. The asymmetrical leading end allows for the sate use of an implant of maximum length for the implantation space into which it is installed. The implant can also include an asymmetric trailing end adapted to sit upon the more peripheral areas of the vertebral end plate region of the vertebral bodies.

Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods

A system includes a scleral prosthesis and an insert. The scleral prosthesis includes an elongated body having a first free end and a second free end opposite the first end. A maximum width of the body at each end is wider than a maximum width of the body between the ends. The body includes multiple first portions that form the first end of the body and a part of the body between the ends. The first portions are separated lengthwise along a substantial portion of a total length of the body. The first portions are biased so that they maintain separation from one another without external interference but are configured to be pushed towards each other. The insert is configured to be placed between the first portions to maintain a separation of the first portions. The body and/or the insert could be formed using one or more magnetic materials.

Methods and Compositions for Articular Repair

Disclosed herein are methods and compositions for producing articular repair materials and for repairing an articular surface. In particular, methods for providing articular repair systems. Also provided are articular surface repair systems designed to replace a selected area cartilage, for example, and surgical tools for repairing articular surfaces.

Hard-tissue implant

Hard-tissue implants are provided that include a bulk implant, a face, pillars, and slots. The pillars are for implantation into a hard tissue. The slots are to be occupied by the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 10 GPa, has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1, does not comprise any part that is hollow, and does not comprise any non-pillar part extending to or beyond the distal ends of any of the pillars. Methods of making and using hard-tissue implants are also provided.

Partial joint resurfacing implant, instrumentation, and method

A partial resurfacing implant for use in repairing an articular cartilage defect site that includes a top articulating portion having a top surface that is configured with at least one radius of curvature to approximate the surface contour of the articular cartilage surrounding the defect site. The implant also includes a supporting plate that has a top surface and a bottom surface. The top surface is attached to the top articulating portion by a locking mechanism. The bottom surface of the supporting plate is constructed to facilitate the insertion of the implant into the defect site. Extending from the bottom surface of the supporting plate is at least one implant fixation portion. The at least one implant fixation portion is integrally connected to and is oriented about normal relative to the bottom surface. A method of repairing an articular cartilage defect with the partial joint resurfacing implant is also disclosed.

Bioabsorbable polymer, non-bioabsorbable metal composite stents

Biocompatible materials may be configured into any number of implantable medical devices including intraluminal stents. The biocompatible material may comprise metallic and non-metallic materials in hybrid structures. In one such structure, a device may be fabricated with one or more elements having an inner metallic frame that is not degradable with an outer shell formed from a polymeric material that is biodegradable by extrusion blow molding. Additionally, therapeutic agents may be incorporated into the microstructure or the bulk material.

Systems and methods for the fixation or fusion of bone

A stem-like bone fixation device allows for bony in-growth on its surface and across fracture fragments or between bones that are to be fused.

Device for endovascular aortic repair and method of using the same

A device and method for endovascular repair of a patient's aorta is disclosed. The device includes a frame component that has a balloon-expandable frame and a self-expanding frame secured to the balloon-expandable frame. The device also includes a valve element positioned at the proximal end of the frame component. The device may include another prosthetic component that may be secured to the frame component. The prosthetic component may include at least one conduit configured to receive a covered stent.

Expandable interbody implant and methods of use

An intervertebral implant is provided. The intervertebral implant comprises a first component comprising an outer tissue engaging surface and an inner surface. A second component is connected to the first component, and is relatively moveable thereform. The second component comprises an outer tissue engaging surface and an inner surface. The second component includes an actuator. A third component is disposed for engagement and is movable relative to the first and second components. The third component comprises at least a first ramp and a second ramp axially spaced apart from the first ramp. The actuator is engageable with the third component to effect axial translation of the wedge such that the ramps engage the inner surface of at least one of the first component and the second component to move the components between a first, collapsed configuration and a second, expanded configuration. Methods of use are disclosed.

Disintegrating stent and method of making same

A temporary stent endoprosthesis that does not require an interventional procedure for removal. The disintegrating stent is preferably made from a bioabsorbable polymer, such as by braiding polymer monofilaments into a tubular mesh shape, and the polymer has fracture initiation sites within it that promotes the disintegration of the stent into small pieces that are harmlessly transported out of the body by the vessel contents. Fracture initiation sites may be created by controlling the heterogenous structure of amorphous and crystalline regions, by introducing internal or surface fracture initiation sites, or use of multiple strands with small section size.

Suspension liner system with seal

A suspension liner sleeve adapted to provide an interface between a residual limb and a prosthetic socket, and having outer and inner surfaces. The liner sleeve includes an elongate, generally conical body portion formed from at least one material segment defining the liner outer surface. The at least one material segment being at least radially elastically extensible from a relaxed non-extended condition and including proximal and distal end areas. The liner sleeve includes a layer of polymeric material disposed on the at least one material segment and defining the liner sleeve inner surface, and a plurality of resilient seal elements protruding radially from the liner sleeve outer surface. The plurality of seal elements extend around at least one peripheral portion of the liner body portion. A pair of opposed annular recesses may be adjacently located above and below each of the at least one seal element.

Rim anchoring systems for flexible surgical implants for replacing cartilage

Flexible cartilage-replacing implants are disclosed that use either or both of ( 1 ) enlarged peripheral rim components, and/or ( 2 ) elongated flexible reinforcing members that are embedded around the peripheral edge of an implant device. These types of anchoring devices, especially when used in combination, can provide flexible implants that can be implanted arthroscopically into synovial joints, for complete replacement of damaged cartilage segments.

Selectively Expanding Spine Cage With Enhanced Bone Graft Infusion

A selectively expanding spine cage has a minimized cross section in its unexpanded state that is smaller than the diameter of the neuroforamen through which it passes in the distracted spine. The cage conformably engages between the endplates of the adjacent vertebrae to effectively distract the anterior disc space, stabilize the motion segments and eliminate pathologic spine motion. Expanding selectively (anteriorly, along the vertical axis of the spine) rather than uniformly, the cage height increases and holds the vertebrae with fixation forces greater than adjacent bone and soft tissue failure forces in natural lordosis. Stability is thus achieved immediately, enabling patient function by eliminating painful motion. The cage shape intends to rest proximate to the anterior column cortices securing the desired spread and fixation, allowing for bone graft in, around, and through the implant for arthrodesis whereas for arthroplasty it fixes to endpoints but cushions the spine naturally.

Pelvic Implant System and Method

Systems and methods are provided and adapted to engage and pull (e.g., pull up) or reposition urethral support tissue, such as the portion of the perineal membrane above or below the urethra. The perineal membrane intersects the urethra and vagina at the midurethra or distal location and can thus be stabilized or controlled in a manner that helps restore continence.

Stentless Support Structure

A stentless support structure capable of being at least partly assembled in situ. The support structure comprises a braided tube that is very flexible and, when elongated, becomes very long and very small in diameter, thereby being capable of placement within a small diameter catheter. The support structure is preferably constructed of one or more thin strands of a super-elastic or shape memory material such as Nitinol. When released from the catheter, the support structure folds itself into a longitudinally compact configuration. The support structure thus gains significant strength as the number of folds increase. This radial strength obviates the need for a support stent. The support structure may include attachment points for a prosthetic valve.

Assembly comprising a ring for attachment in a passage surrounded by body tissue as well as an applicator for fitting the ring in the passage

The present invention relates to an assembly comprising: a ring having anchoring elements for attaching the ring in a passage surrounded by body tissue, in particular blood vessel tissue. an applicator for fitting the ring in the passage; in which the anchoring elements have an anchoring position in which they protrude with respect to the ring, and in which the anchoring elements comprise a memory material, such as a memory metal or memory polymer, and are designed so that they can be bent from an anchoring position counter to a spring force into a fitting position and can be frozen in this fitting position by a temperature treatment in order to bend the anchoring elements back from the fitting position by the effect of this spring force into the anchoring position when a predetermined threshold temperature is exceeded, and in which the applicator is provided distally with a carrier for carrying the ring. The assembly according to the invention is provided with an influencing system for influencing the temperature of the anchoring elements of the ring carried by the carrier in such a way that the anchoring elements bend back from the fitting position to the anchoring position by increasing the temperature of the anchoring elements to above the threshold temperature.

Implant with a base body of a biocorrodible alloy

An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CF x layer that is nonpolymerized and has an F/C ratio in the range of 0.5 to 1.5.

Two-stage collapsible/expandable prosthetic heart valves and anchoring systems

Prosthetic heart valve apparatus is adapted for delivery into a patient in a circumferentially collapsed condition, followed by circumferential re-expansion at the implant site in the patient. The apparatus includes an annular anchoring structure that can be implanted in the patient first. The apparatus further includes an annular valve support structure, which supports a flexible leaflet structure of the valve. The support and leaflet structures are initially separate from the anchoring structure, but they can be implanted in the patient by interengagement of the support structure with the already-implanted anchoring structure.

Slide-and-lock stent

The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

Apparatus, systems, and methods for achieving lumbar facet fusion

Assemblies of one or more implant structures make possible the achievement of diverse interventions involving the fusion and/or stabilization of lumbar and sacral vertebra in a non-invasive manner, with minimal incision, and without the necessitating the removing the intervertebral disc. The representative lumbar spine interventions, which can be performed on adults or children, include, but are not limited to, lumbar interbody fusion; translaminar lumbar fusion; lumbar facet fusion; trans-iliac lumbar fusion; and the stabilization of a spondylolisthesis.

Flanged interbody fusion device with fastener insert and retaining ring

Methods and devices are disclosed for treating the vertebral column. An integrated fixation plate and spacer having a retaining structure within the screw holes of the fixation plate to resist backout of screws attaching the fixation plate to the bone is provided. A movable joint may be provided between the fixation plate and spacer. In some embodiments, a screw hole insert is also provided to resist shear forces acting between the screw and fixation plate. In some embodiments, an integrated fixation plate and spacer system is provided, comprising two or more integrated fixation plate and spacer implants, wherein the fixation plates of each implant has a complementary configuration to allow attachment of the implants at adjacent intervertebral spaces. Alternative fixation systems are also contemplated.

Adjustable Valve For IOP Control With Reed Valve

A drainage device for implantation in an eye of a patient to treat an ocular condition, that includes an implant body portion comprising of a valve portion. The valve portion may comprise a flexible membrane disposed and arranged in a manner to affect flow of aqueous humor through the implant body portion. The device may also include a reed valve disposed downstream of the flexible membrane. The reed valve may be configured to prevent backflow of aqueous humor toward the membrane and configured to stabilize flow by affecting pressure at the flexible membrane. In one aspect, the reed valve is configured to create backpressure at the membrane that affects the rate of flow at the flexible membrane.

Methods of building a body portion

An improved method of implanting cells in the body of a patient includes positioning viable cells on a support structure. One or more blood vessels may be connected with the support structure to provide a flow of blood through the support structure. A support structure may be positioned at any desired location in a patient's body. The support structure may be configured to replace an entire organ or a portion of an organ. An organ or portion of an organ may be removed from a body cells and/or other tissue is removed to leave a collagen matrix support structure having a configuration corresponding to the configuration of the organ or portion of an organ. Alternatively, a synthetic support structure may be formed. The synthetic support structure may have a configuration corresponding to a configuration of an entire organ or only a portion of an organ.

Device and method for reducing mitral valve regurgitation

In one embodiment, the present invention provides a prosthesis that can be implanted within a heart to at least partially block gaps that may be present between the two mitral valve leaflets. In one preferred embodiment, the prosthesis includes an anchoring ring that expands within the left atrium to anchor the prosthesis and a pocket member fixed to the anchoring ring. When the mitral valve is open, blood flows past the pocket member, maintaining the pocket member in a collapsed state. When the mitral valve closes, the backpressure of the blood pushes into the pocket member, expanding the pocket member to an inflated shape. The mitral valve leaflets contact the expanded pocket member, allowing the prosthesis to block at least a portion of the openings between the leaflets, thereby minimizing regurgitated blood flow into the left atrium.

Method for Reducing or Preventing Transplant Rejection in the Eye and Intraocular Implants for Use Therefor

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

Hollow drug-filled stent and method of forming hollow durg-filled stent

A stent is formed from a wire having an outer member, a radiopaque member lining at least a portion of the outer member inner surface, and a lumen defined by the outer member inner surface or the radiopaque member inner surface. A substance is disposed in the lumen to be eluted through at least one opening disposed through the outer member to the lumen. The radiopaque member may be substantially continuous along the length of the wire or disposed only along portions of the wire such as crowns. In a method for making the stent, a composite wire including an outer member, a radiopaque intermediate member, and a core member is shaped into a stent pattern and processed to remove the core member and optionally portions of the radiopaque intermediate member, without damaging the outer member.

Bioabsorbable Polymeric Compositions and Medical Devices

The present invention comprises a stent comprising a blend formed from a polymer. The polymer comprises poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with ε-caprolactone or trimethylcarbonate. The poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of ε-caprolactone or trimethylcarbonate and the copolymer moiety molecular weight ranges from about 1.2 IV to about 4.8 IV. The meandering elements may be stretched to a modulus ranging from about 250000 PSI to about 550,000 PSI. One, two, three, n or all segments of the meandering element may have a decreased cross-sectional area and may have a wide-angle X-ray scattering (WAXS) 2θ values of ranging from about 1 to about 35 after stretching. The crystal properties of the bioabsorbable polymers may change during crimping and/or expansion allowing for improved mechanical properties such as tensile strength and slower degradation kinetics.

Drug eluting ocular implant

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Percutaneous transcatheter repair of heart valves

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.