ИМПЛАНТАТ ДЛЯ ПЕРЕКРЫТИЯ ДЕФЕКТОВ КОСТИ В ЧЕЛЮСТНОЙ ЗОНЕ, А ТАКЖЕ СПОСОБ ЕГО ИЗГОТОВЛЕНИЯ

Группа изобретений относится к медицинской технике, а именно к рассасывающемуся имплантату для перекрытия дефектов кости в челюстной зоне, а также к способу его изготовления. Имплантат для перекрытия дефектов кости, в частности, в челюстной зоне состоит из магниевой плёнки. Магниевая плёнка по меньшей мере в одной средней зоне не имеет отверстий. Набор для перекрытия дефектов кости в челюстной зоне включает в себя вышеуказанный имплантат, а также штифты, винты или нити для фиксации имплантата в челюсти. Способ изготовления имплантата для перекрытия дефектов кости в челюстной зоне, в частности, вышеуказанного имплантата, причём подготавливают магниевую плёнку, магниевую плёнку укорачивают до длины перекрываемого места и изгибают. Способ хирургической реконструкции челюсти, причём вышеуказанный имплантат устанавливается над местом дефекта челюсти, так что мягкая ткань над местом дефекта перекрывается. Изобретения характеризуются рассасывающимся имплантатом, который может быть легко установлен ...

Advanced methods, techniques, devices, and systems for cruciate retaining knee implants

Improved implants, systems, tools and related methods for bi-cruciate retaining joint treatment are disclosed, including patient-adapted implants, systems, tools, and methods. Lif ...

Polyurethane/urea materials

The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.

POLYURETHANE/UREA MATERIALS

The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.

MITRAL VALVE SPACER DEVICE

An implantable prosthetic spacer device can include an inflatable spacer having a plurality of inflatable members and a frame, the frame comprising one or more anchors and one or more clasps. The inflatable spacer can be configured to be disposed between native leaflets of a heart. The implantable prosthetic spacer can be disposed in a symmetrical or an asymmetrical configuration. The inflatable spacers can be inflatable between an uninflated and an inflated configuration.

TAPERED IMPLANTABLE DEVICE AND METHODS FOR MAKING SUCH DEVICES

A tapered implantable device includes an ePTFE tubular member having a tapered length portion. The tapered length portion provides rapid recovery properties. The tapered length portion can feature a microstructure that includes a multiplicity of bent fibrils.

METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING NERVE GUIDES AND PATCHES

... ²A medical nerve guide or cuff, comprises an elastic tube with a wall ²surrounding an axially ²extending cavity, the wall having at least one collagen fiber of a continuous ²length arranged in a fiber ²mesh pattern of overlying intersecting segments over at least a major length ²of the tube, the at least ²one collagen fiber embedded in a collagen film that extends over interstitial ²spaces defined by the fiber ²mesh pattern, and wherein the fiber mesh pattern is visually observable, ²wherein the collagen film ²comprises collagen fibers, fibrils and/or microfibrils.² ...

CUP FOR AN ORTHOPEDIC IMPLANT, AN ORTHOPEDIC IMPLANT COMPRISING SUCH A CUP AND CUP METHOD OF MAKING SAME

경량의 4축 외과용 메시의 제조 방법

... 제1 웨일 방향으로 제1 세트의 필라멘트들을 적용하는 단계 및 각각의 다수의 코스에서 제1 시리즈의 루프들을 형성하는 단계를 갖는 경량의 외과용 메시의 제조 방법. 제1 웨일 방향으로 제2 세트의 필라멘트들을 적용하는 단계 및 다수의 코스를 따라 제1 웨일 방향의 제1 인접 웨일에서 제2 시리즈의 루프들 및 제1 인접 웨일에 대향하는 제2 인접 웨일에서 제3 시리즈의 루프들을 형성하는 단계. 또한, 다수의 코스를 따라 제2 인접 웨일에서 제2 시리즈의 루프들이 형성되고 제1 인접 웨일에서 제3 시리즈의 루프들이 형성되도록, 제1 웨일 방향으로 제3 세트의 필라멘트들을 적용하는 단계. 또한, 제1 웨일 방향을 따라 제1 세트의 필라멘트들과 여러차례 인터레이스(interlace)하는 제4 세트의 필라멘트들을 적용하는 단계.

Heart valve sealing devices and delivery devices therefor

A mitral valve repair system includes a delivery sheath, a mitral valve repair device, and an actuator. The mitral valve repair device is disposed in the delivery sheath in an extended condition. The mitral valve repair device includes a pair of barbed clasps. The barbed clasps are in a closed condition while the mitral valve repair device is in the extended condition in the delivery sheath.

УСТРОЙСТВО ДЛЯ УПЛОТНЕНИЯ СЕРДЕЧНОГО КЛАПАНА И УСТРОЙСТВО ДЛЯ ЕГО ДОСТАВКИ

Группа изобретений относится к медицинской технике. Устройство для коррекции атриовентрикулярного клапана пациента содержит смыкающий элемент, имеющий первую концевую часть и вторую концевую часть; пару лепестков, соединенных со второй концевой частью смыкающего элемента. Смыкающий элемент сужается от первой концевой части смыкающего элемента ко второй концевой части. Лепестки выполнены с возможностью перемещения между открытым положением и закрытым положением и возможностью крепления к атриовентрикулярному клапану пациента. Раскрыты варианты устройства, варианты системы и способа коррекции атриовентрикулярного клапана, способ имплантации устройства и способ освобождения захвата устройства. Изобретения позволяют обеспечить эффективное уплотнение, способствуя смыканию собственных створок вокруг смыкающего элемента. 11 н. и 113 з.п. ф-лы, 144 ил., 3 табл.

УСТРОЙСТВО ДЛЯ УПЛОТНЕНИЯ СЕРДЕЧНОГО КЛАПАНА И УСТРОЙСТВО ДЛЯ ЕГО ДОСТАВКИ

Atraumatic stent and method and apparatus for making the same

A method of braiding a stent includes braiding a number of elongate filaments around a mandrel using tensioned braiding carriers without spooling the filaments to the tensioned braiding carriers to form a braided stent having atraumatic ends.

Medical device provided with sensors

The invention relates to a medical device (12) comprising an electrical measurement circuit (16), in which are connected at least two variable-impedance sensors (22), the impedance of which varies according to a detected physical quantity, an electrical power source (18) for supplying power to the electrical measurement circuit (16), an antenna (18) for emitting an electromagnetic field according to the impedance of the electrical measurement circuit (16), each of the sensors (22) being associated with a switch (24) for interrupting the current supply of the sensor (22) in said measurement circuit (16), the medical device (12) additionally comprising a system (26) for controlling the switches (24) in order to successively control the opening or the closing of the switches (24), according to determined configurations. The medical device (12) may in particular be applied to the human body or implanted within the human body.

Methods and devices for in situ formed nerve cap

Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth ...

Tapered implantable device and methods for making such devices

A tapered implantable device includes an ePTFE tubular member having a tapered length portion. The tapered length portion provides rapid recovery properties. The tapered length portion can feature a microstructure that includes a multiplicity of bent fibrils.

SOFT TISSUE GRAFTS, AND METHODS OF MAKING AND USING SAME

METHODS AND DEVICES FOR IN SITU FORMED NERVE CAP

Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth ...

APPARATUS AND METHOD FOR MOUNTING AN EXTERNAL SCAFFOLD TO A VASULAR GRAFT

A method for securing a compliant scaffold to an outer surface of a vascular graft includes positioning the scaffold radially about an elongated support tube which includes first and second radially outwardly flared end portions respectively defining first and second open ends of the support tube. The method further includes pulling the vascular graft through a lumen of the support tube, and axially deploying the scaffold over the first end portion of the support tube and into compliant contact with the outer surface of the vascular graft.

ＰＬＬＡ로부터 제조된 풍선 팽창성 스텐트

... 의료 장치는 팽창 풍선을 갖는 카테터에 크림핑된 중합체 스캐폴드를 포함한다. 상기 스캐폴드는, 말초 혈관 내에 이식시 후기 내강 손실이 낮고 또한 축방향 피로 수명이 높은 구조를 갖는다. 바람직한 양태에서, 상기 스캐폴드는 링크들에 의해 상호연결된 고리 구조들을 형성하며, 고리는 12개의 크라운들, 및 인접한 고리들을 연결하는 2개 이하의 링크들을 갖는다.

비외상성 스텐트 및 그를 제조하는 방법 및 장치

... 스텐트를 꼬는 방법은 필라멘트를 장력이 가해진 꼬임 캐리어에 감지 않고 장력이 가해진 꼬임 캐리어를 사용하여 맨드렐 주위로 다수의 기다란 필라멘트를 꼬아서 비외상성 단부를 갖는 꼬아진 스텐트를 형성하는 것을 포함한다.

WEAVING METHOD FOR NASAL SINUS STENT AND STENT OBTAINED THEREOF

The present invention relates to a weaving method for a nasal sinus stent, comprising: providing a filament; providing a weaving tool having a longitudinal central axis, wherein the weaving tool comprises a first shaping part and a second shaping part which are axially spaced from each other, wherein the first shaping part is provided with n first anchor points, and the second shaping part is provided with n second anchor points; forming an initial configuration stent by around a circumferential direction of the weaving tool, allowing a single filament starting from 1st first anchor point on the first shaping part, coming across m1 vertex intervals to extend towards the second anchor point, and then coming across m2 vertex intervals to extend towards the first anchor point, so as to complete a first “V” shaped weaving path, and then repeating the “V” shaped weaving path until the single filament returns to the 1st first anchor point, wherein the initial configuration stent has a circumference ...

Method for attaching radiopaque markers to a stent

A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis.

ATRAUMATIC STENT AND METHOD AND APPARATUS FOR MAKING THE SAME

A method of braiding a stent includes braiding a number of elongate filaments around a mandrel using tensioned braiding carriers without spooling the filaments to the tensioned braiding carriers to form a braided stent having atraumatic ends.

Inflatable insertion device for percutaneous insertion

The invention provides an inflatable insertion device capable of being percutaneously introduced into a patient's body. The insertion device comprises an inflatable element having a distal end and a proximal end and which is operable between a collapsed condition and an inflated condition by introducing an inflating fluid therein. An elongate member extends internally of the inflatable element from its distal end. The internal member is capable of being withdrawn towards the proximal end of the inflatable element to result in the distal end of the element being withdrawn towards the proximal end internally of the element. The invention further provides a locating device comprising a catheter having a catheter tube fitted with one or more inflatable insertion devices at a distal end thereof.

СПОСОБ ИЗГОТОВЛЕНИЯ ОБЛЕГЧЕННОЙ ЧЕТЫРЕХОСНОЙ ХИРУРГИЧЕСКОЙ СЕТКИ

Способ изготовления облегченной хирургической сетки, включающий этапы расположения первого набора нитей в направлении первого петельного столбика и образования первого набора петель на каждом из множества петельных рядов. Расположение второго набора нитей в направлении первого петельного столбика и образование второго набора петель на первом соседнем петельном столбике к направлению первого петельного столбика и третьего набора петель на втором соседнем петельном столбике, противоположном первому соседнему петельному столбику вдоль множества петельных рядов. Также расположение третьего набора нитей в направлении первого петельного столбика таким образом, чтобы образовывать второй набор петель на втором соседнем петельном столбике и образовывать третий набор петель на первом соседнем петельном столбике вдоль множества петельных рядов. Дополнительно, расположение четвертого набора нитей, несколько раз переплетенных с первым набором нитей, вдоль направления первого петельного столбика. 14 ...

СПОСОБ ИЗГОТОВЛЕНИЯ ОБЛЕГЧЕННОЙ ЧЕТЫРЕХОСНОЙ ХИРУРГИЧЕСКОЙ СЕТКИ

Removable anchored lung volume reduction devices

The device 10 comprises a frame structure including a hub section 28 and anchors 26 as well as a frameless membrane 30 having a base section 34 configured to be attached to the hub section. The anchors and the frameless membrane have open (figs 1-4) and closed (fig 5) configurations. The frameless membrane may comprise a plurality of pedals 32 coupled to the base section. In the open configuration, the pedals curve away from the central longitudinal axis of the one-way valve device. Proximal sections of the pedals may overlap proximal sections of adjacent pedals when the one-way valve device is in the open or closed configurations. The device may comprise a second frameless membrane (108 fig 3).

Biodegradable vascular filter

Electropolishing apparatus and method for medical implants

Polyurethane/Urea Materials

Abstract The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.

Bioabsorbable filament medical devices

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a filament and a membrane arranged about the filament. The membrane may be configured to contain fragments of the filament and maintain structure of the membrane in response to the fracture or degradation of the filament.

INTRAOCULAR LENS MATERIALS AND COMPONENTS

Materials and methods of manufacturing intraocular lenses, including polymeric materials for the intraocular lenses, fluids for intraocular lenses, and adhesives for intraocular lenses. The intraocular lenses can include an optic portion and a peripheral region in fluid communication.

ADVANCED METHODS, TECHNIQUES, DEVICES, AND SYSTEMS FOR CRUCIATE RETAINING KNEE IMPLANTS

Improved implants, systems, tools and related methods for bi-cruciate retaining joint treatment are disclosed, including patient-adapted implants, systems, tools, and methods.

SYNTHETIC PROSTHESIS COMPRISING A KNIT AND A NON POROUS FILM AND METHOD FOR FORMING SAME

The present invention relates to a synthetic prosthesis for tissue reinforcement comprising : - a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, - a synthetic non porous biodegradable film comprising at least a copolymer of at least .epsilon.-caprolactone, said film covering at least part of said first face, - a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of .epsilon.-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING TUBES

The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.

METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING TUBES FOR AUTO AND/OR ALLO-GRAFTS

The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.

POLYMERIC TRILEAFLET HEART VALVE PROSTHESIS

A polymeric heart valve is disclosed including: a valve body having a central axis having a body fluid pathway extending along the central axis from an inflow end to an outflow end; a flexible stent disposed about an outer circumference of the body and including at least three flexible stent posts each extending in the axial direction to a tip; and at least three flexible leaflets extending from the stent, each of the leaflets having an attached edge defining an attachment curve along the stent extending between a respective pair of stent posts.

POLYMERIC TRILEAFLET HEART VALVE PROSTHESIS

A polymeric heart valve is disclosed including: a valve body having a central axis having a body fluid pathway extending along the central axis from an inflow end to an outflow end; a flexible stent disposed about an outer circumference of the body and including at least three flexible stent posts each extending in the axial direction to a tip; and at least three flexible leaflets extending from the stent, each of the leaflets having an attached edge defining an attachment curve along the stent extending between a respective pair of stent posts.

APPARATUS AND METHOD FOR MOUNTING AN EXTERNAL SCAFFOLD TO A VASCULAR GRAFT

A method for securing a compliant scaffold to an outer surface of a vascular graft includes positioning the scaffold radially about an elongated support tube which includes first and second radially outwardly flared end portions respectively defining first and second open ends of the support tube. The method further includes pulling the vascular graft through a lumen of the support tube, and axially deploying the scaffold over the first end portion of the support tube and into compliant contact with the outer surface of the vascular graft.

ATRAUMATIC STENT AND METHOD AND APPARATUS FOR MAKING THE SAME

A method of braiding a stent includes braiding a number of elongate filaments around a mandrel using tensioned braiding carriers without spooling the filaments to the tensioned braiding carriers to form a braided stent having atraumatic ends.

CORRECTION OF SURGICALLY-INDUCED ASTIGMATISM DURING INTRAOCULAR LENS IMPLANTS

In one aspect, the present invention provides a method of designing an oc ular implant (e.g., an IOL), which comprises establishing corneal topography of a patient's eye, e.g., by performing one or more wavefront aberration me asurements of the eye, prior to an ocular surgery. The method further includ es ascertaining an astigmatic aberration of the cornea that is expected to b e induced by the surgery and determining a toricity of a surface of an ocula r implant, which is intended for implantation in the patient's eye, so as to enable the implant to compensate for the surgically-induced aberration. ...

POLYURETHANE/UREA MATERIALS

The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.

Adjustable support for tubular medical device processing

An apparatus and method for supporting a tubular medical device, such as a stent or scaffold, includes a rod disposed between two collets. The rod can be shaped to form a range of different size or length helical supports to support a wide range of tubular medical devices. The rod is shaped into a full or partial helix by rotating one of the collets relative to the other.

Tapered implantable device and methods for making such devices

A tapered implantable device includes an ePTFE tubular member having a tapered length portion. The tapered length portion provides rapid recovery properties. The tapered length portion can feature a microstructure that includes a multiplicity of bent fibrils.

Correction of surgically-induced astigmatism during intraocular lens implants

In one aspect, the present invention provides a method of designing an ocular implant (e.g., an IOL), which comprises establishing corneal topography of a patient's eye, e.g., by performing one or more wavefront aberration measurements of the eye, prior to an ocular surgery. The method further includes ascertaining an astigmatic aberration of the cornea that is expected to be induced by the surgery and determining a toricity of a surface of an ocular implant, which is intended for implantation in the patient's eye, so as to enable the implant to compensate for the surgically-induced aberration.

Method and system for advanced transcatheter aortic valve implantation planning

A method and system for transcatheter aortic valve implantation (TAVI) planning is disclosed. An anatomical surface model of the aortic valve is estimated from medical image data of a patient. Calcified lesions within the aortic valve are segmented in the medical image data. A combined volumetric model of the aortic valve and calcified lesions is generated. A 3D printed model of the heart valve and calcified lesions is created using a 3D printer. Different implant device types and sizes can be placed into the 3D printed model of the aortic valve and calcified lesions to select an implant device type and size for the patient for a TAVI procedure. The method can be similarly applied to other heart valves for any type of heart valve intervention planning.

BRAIDED STENT

A braided stent (24) comprising a plurality of elongate filaments (20) inter-braided to form a braided tubular structure, the filaments (20) being inter-braided at a braiding angle (ß) formed at crossing filament locations, the braided tubular structure comprising a first portion (40) having a first diameter, a second portion (42) having a second diameter which is different from the first diameter and a transition portion disposed between the first portion and the second portion; and wherein the braiding angle (ß) in the first portion (40), the braiding angle (ß) in the second portion (42), and the braiding angle (ß) in the transition portion are within 5 degrees of one another.

СПОСОБ КОНСТРУИРОВАНИЯ ИМПЛАНТАТА ВНУТРИГЛАЗНОЙ ЛИНЗЫ ДЛЯ ИСПРАВЛЕНИЯ АСТИГМАТИЗМА, ВЫЗВАННОГО ХИРУРГИЧЕСКОЙ ОПЕРАЦИЕЙ

... 1. Способ конструирования глазного имплантата, включающий установление топографии роговицы глаза пациента посредством выполнения одного или нескольких измерений аберраций волнового фронта глаза перед глазной хирургической операцией, ! обнаружение одной или нескольких аберраций, включая астигматические аберрации указанной роговицы, вызванные хирургической операцией, и ! определение торичности для поверхности глазного имплантата для того, чтобы позволить имплантату обеспечить компенсацию указанных одной или нескольких вызванных хирургической операцией аберраций. ! 2. Способ по п.1, где этап обнаружения одной или нескольких вызванных хирургической операцией аберраций включает моделирование одной или нескольких аберраций, вызванных указанной глазной хирургической операцией. ! 3. Способ по п.2, где этап моделирования одной или нескольких вызванных хирургической операцией аберраций включает применение методики векторного анализа. !4. Способ по п.2, более того содержащий применение указанных измерений ...

Gefäßprothesensystem, Herstellungsverfahren und Verfahren zur Einbringung der Gefäßprothese des Gefäßprothesensystems in ein Blutgefäß

Die vorliegende Erfindung betrifft ein Gefäßprothesensystem (50), umfassend zumindest eine Gefäßprothese (1) zum Einführen in ein Blutgefäß eines menschlichen Körpers, sowie ein Herstellungsverfahren für das Gefäßprothesensystem. Die Gefäßprothese (1) weist im Gefäßprothesenmaterial (12) zumindest einen, zwischen dem proximalen (3) und dem distalen Ende (4) gelegenen Lochungsbereich (10) mit zumindest einem Loch (100) auf, wobei das zumindest eine Loch (100) einen geschlossenen umlaufenden Rand (102) aufweist.

An inflatable insertion device for percutaneous insertion

SYSTEMS AND METHODS FOR LIGAMENT GRAFT PREPARATION

Systems and methods for preparing a ligament graft for a ligament reconstruction procedure are provided. In general, the described techniques utilize a graft preparation system having a holder and a delivery suture assembly removably coupled thereto. The delivery suture assembly can include a spine coupled with an anchor suture configured to form a self-tightening knot used to position the assembly around a graft and a plurality of suture windings configured to be affixed to the graft when the assembly is deployed. The assembly is delivered to the graft using the holder and the sutures can be affixed to the graft without penetrating therethrough. The spine helps to evenly distribute the load among the windings compressing the graft which are thus are capable of withstanding increased loads. Thus, an improved, simplified, and time- and labor-saving approach to preparing ligament grafts is provided. 06/07/1 22?Rn0 -n-i 1'7 ...

Advanced methods, techniques, devices, and systems for cruciate retaining knee implants

Improved implants, systems, tools and related methods for bi-cruciate retaining joint treatment are disclosed, including patient-adapted implants, systems, tools, and methods.

HEART VALVE SEALING DEVICES AND DELIVERY DEVICES THEREFOR

An exemplary implantable prosthetic device has a coaption element and at least one anchor. The coaption element is configured to be positioned within the native heart valve orifice to help fill a space where the native valve is regurgitant and form a more effective seal. The coaption element can have a structure that is impervious to blood and that allows the native leaflets to close around the coaption element during ventricular systole to block blood from flowing from the left or right ventricle back into the left or right atrium, respectively. The coaption element can be connected to leaflets of the native valve by the anchor.

SOFT TISSUE GRAFTS, AND METHODS OF MAKING AND USING SAME

Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi- directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

SOFT TISSUE GRAFTS, AND METHODS OF MAKING AND USING SAME

Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

MANUFACTURING AN ARTICULATING OPHTHALMIC SURGICAL PROBE

A method of manufacturing an articulating ophthalmic surgical probe includes providing a cannula having an outer diameter of 20 Ga or less and a slotted tip, permanently attaching a pull wire to the slotted tip, permanently attaching a metal anchor to a distal end of the pull wire, positioning a weld pin within a handle assembly that is sized to fit within a single hand, and welding the metal anchor to the weld pin within the handle assembly.

PANCREATIC STENT WITH DRAINAGE FEATURE

A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.

GLENOID IMPLANT

A glenoid component can include a base plate (110). A glenosphere (112) can be configured to be mountable to the base plate. The glenosphere can be adapted to operate with a complementary humeral component (102). The base plate can include a removable taper member (302) on a side of the base plate facing the glenosphere. The taper member can be configured to mount the glenosphere to the base plate. The removable taper member allows revision of the glenoid component without removal of the components fixed to the bone.

CUP FOR ORTHOPEDIC IMPLANT, ORTHOPEDIC IMPLANT INCLUDING/UNDERSTANDING SUCH A CUP AND A METHOD FOR CARRYING OUT SUCH A CUP

Cette cupule (2) présente une cavité interne (4), pour un organe d'articulation (14), et une couche externe (10) métallique et en portion de sphéroïde. La couche externe (10) comprend des réseaux (20) de mailles (22) avec nœuds (24) et entretoises (25, 26). Les entretoises (25, 26) comprennent des entretoises dites effilées (26) qui ont chacune une forme effilée. Les entretoises effilées (26) sont agencées de sorte que les formes effilées sont orientées de manière uniforme.

Surgical Implant and Process of Manufacturing Thereof

A surgical implant (20) comprises a flexible, areal basic structure (22) having a first face and a second face and being provided with pores (26) extending from the first face to the second face. A barrier layer (24) having a first face and a second face is placed, with its second face, at the first face of the basic structure (2) and attached to the basic structure (22). The barrier layer (24) is deformed into at least part of the pores (26) where it forms, in a respective pore (10), a barrier region (28).

Atraumatic stent and method and apparatus for making the same

A method of braiding a stent includes braiding a number of elongate filaments around a mandrel using tensioned braiding carriers without spooling the filaments to the tensioned braiding carriers to form a braided stent having atraumatic ends.

METHOD FOR PRODUCING A PROSTHETIC SLEEVE TO MEASURE

FULL CONTOUR BREAST IMPLANT

ИМПЛАНТАТ ДЛЯ ПЕРЕКРЫТИЯ ДЕФЕКТОВ КОСТИ В ЧЕЛЮСТНОЙ ЗОНЕ, А ТАКЖЕ СПОСОБ ЕГО ИЗГОТОВЛЕНИЯ

НАДУВНОЕ УСТРОЙСТВО ВВОДА ДЛЯ ПОДКОЖНОГО ВВЕДЕНИЯ

Prosthesis for hernia repair

PROSTHESIS FOR HERNIA REPAIR A prosthesis (1) for treating a hernia defect in the abdominal wall comprising at least one reinforcement layer (2), comprising a biocompatible porous material, said reinforcement layer including a first surface (2a) intended to face the abdominal wall and a second surface (2b) opposite said first surface, said reinforcement layer being delimited by an outer edge (2c); at least one first barrier layer (3), comprising a biocompatible anti-adhesion material, said first barrier layer including a first surface (3a) and a second surface (3b) opposite said first surface of the first barrier layer, the first surface of the first barrier layer covering substantially at least a central part of the area of the second surface of said reinforcement layer, the second surface of said first barrier layer being intended to face the abdominal cavity, said first barrier layer being delimited by an outer edge (3c); and at least one second barrier layer, said second barrier layer ...

Glenoid implant

A glenoid component can include a base plate (110). A glenosphere (112) can be configured to be mountable to the base plate. The glenosphere can be adapted to operate with a complementary humeral component (102). The base plate can include a removable taper member (302) on a side of the base plate facing the glenosphere. The taper member can be configured to mount the glenosphere to the base plate. The removable taper member allows revision of the glenoid component without removal of the components fixed to the bone.

Manufacturing an articulating ophthalmic surgical probe

A method of manufacturing an articulating ophthalmic surgical probe includes providing a cannula having an outer diameter of 20 Ga or less and a slotted tip, permanently attaching a pull wire to the slotted tip, permanently attaching a metal anchor to a distal end of the pull wire, positioning a weld pin within a handle assembly that is sized to fit within a single hand, and welding the metal anchor to the weld pin within the handle assembly.

LASER TUBE CUTTER WITH IN-SITU MEASURING AND SORTING

A laser tube-cutting machine is disclosed. The tube-cutting machine may include a processing station where raw material enter the machine, a holding and positioning station configured to hold and position the raw material, at least one combined measurement and laser cutting station including a laser and at least one sensor configured to measure various aspects of the tube both before and after cutting, and an outflow processing station where cut material exit the machine.

BIOABSORBABLE FILAMENT MEDICAL DEVICES

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a filament and a membrane arranged about the filament. The membrane may be configured to contain fragments of the filament and maintain structure of the membrane in response to the fracture or degradation of the filament.

TAPERED IMPLANTABLE DEVICE AND METHODS FOR MAKING SUCH DEVICES

A tapered implantable device includes an ePTFE tubular member having a tapered length portion. The tapered length portion provides rapid recovery properties. The tapered length portion can feature a microstructure that includes a multiplicity of bent fibrils.

METHODS OF MAKING BIOCOMPOSITE MEDICAL CONSTRUCTS AND RELATED CONSTRUCTS INCLUDING ARTIFICIAL TISSUES, VESSELS AND PATCHES

The disclosure describes methods of making collagen based biocomposite constructs and related devices. The methods include: (a) winding at least one collagen fiber a number of revolutions about a length of a support member having a long axis, the winding having at least one defined pitch and/or fiber angle relative to the long axis of the support member to form an elongate construct; and (b) applying a fluid polymeric material, such as, for example, an acrylate emulsion and/or other thermoplastic material, onto the collagen fiber during the winding step. Optionally, the fluid polymeric material can include antibiotics and/or other therapeutic agents for additional function/utility.

METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING NERVE GUIDES AND PATCHES

The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.

조직을 제작하기 위한 자동화 장치, 시스템 및 방법

... 본원에서는 조직 및 장기 제작 공정의 자동화를 용이하게 해주는 개선된 바이오프린팅 기술이 개시된다.

HEART VALVE SEALING DEVICES AND DELIVERY DEVICES THEREFOR

SYNTHETIC PROSTHESIS COMPRISING A KNIT AND A NON POROUS FILM AND METHOD FOR FORMING SAME

The invention also relates to a method for forming such a prosthesis.

НАДУВНОЕ УСТРОЙСТВО ВВОДА ДЛЯ ПОДКОЖНОГО ВВЕДЕНИЯ

Группа изобретений относится к медицине, а именно к надувному устройству ввода для подкожного введения в тело пациента, устройству размещения для размещения и позиционирования катетера относительно желаемого размещения, способу размещения и позиционирования катетера относительно желаемого местоположения. Надувное устройство ввода содержит надувной элемент в форме удлиненной трубки с дистальным и проксимальным концом, протягиваемый элемент. Проксимальный конец трубки выполнен с возможностью перехода между сложенным состоянием и надутым состоянием. Протягиваемый элемент выполнен с возможностью быть протянутым внутри надувного элемента от дистального до проксимального конца. В результате этого дистальный конец перемещается к проксимальному концу внутри надувного элемента. Надувной элемент является неэластичным и предварительно установлен до желаемой вытянутой формы, чтобы принять указанную форму при накачке. Протягиваемый элемент является более гибким, чем надувной элемент, когда он накачивается ...

Anti-microbial coating and method of use and manufacture

Removable anchored lung volume reduction devices

Method for making topographical features on a surface of a medical device

The invention relates to methods and apparatus for manufacturing medical devices wherein the medical device has a surface treated to promote the migration of cells onto the surface of the medical device. In particular, the surface of the medical device has at least one topographical feature formed therein.

Polymeric trileaflet heart valve prosthesis

A polymeric heart valve is disclosed including: a valve body having a central axis having a body fluid pathway extending along the central axis from an inflow end to an outflow end; a flexible stent disposed about an outer circumference of the body and including at least three flexible stent posts each extending in the axial direction to a tip; and at least three flexible leaflets extending from the stent, each of the leaflets having an attached edge defining an attachment curve along the stent extending between a respective pair of stent posts.

Medical device provided with sensors

The invention relates to a medical device (12) comprising an electrical measurement circuit (16), in which are connected at least two variable-impedance sensors (22), the impedance of which varies according to a detected physical quantity, an electrical power source (18) for supplying power to the electrical measurement circuit (16), an antenna (18) for emitting an electromagnetic field according to the impedance of the electrical measurement circuit (16), each of the sensors (22) being associated with a switch (24) for interrupting the current supply of the sensor (22) in said measurement circuit (16), the medical device (12) additionally comprising a system (26) for controlling the switches (24) in order to successively control the opening or the closing of the switches (24), according to determined configurations. The medical device (12) may in particular be applied to the human body or implanted within the human body.

FULL CONTOUR BREAST IMPLANT

Full contour absorbable implants for breast surgery redistribute breast volume between the breast's upper and lower poles in exact and desirable ratios. The implants preferably redistribute breast volume so that the upper pole breast volume is 20-40% of the total volume, and the lower pole breast volume is 60-80% of the total volume. The implants are also designed to provide specific curvatures to the poles of the breast, and to angulate the nipple areolar complex slightly skyward so that the patient's nipple is positioned at an angle above the nipple meridian reference line. The implants are designed to be transitory, with sufficient strength retention to allow transition from support of the breast by the implant to support by regenerated host tissue growing in and around the implants, without any significant loss of support during or subsequent to remodeling. The implants may optionally be used with permanent breast implants.

SYSTEMS, DEVICES, AND METHODS FOR HAIR IMPLANTATION

A hair implantation' assembly according to some embodiments of the present disclosure may include a plurality of hair strands and a plurality of hair anchors, each hair anchor retaining a single hair strand and having at least one resilient member associated therewith. The hair implantation assembly may further include a plurality of lumens, each lumen containing a single hair anchor in a manner that compresses an associated at least one resilient member toward an insertion axis of each lumen. The hair implantation assembly may further include a plurality of pushers, each pusher associated with one of the plurality of lumens, and configured to simultaneously expel the plurality of hair anchors into target tissue, wherein the plurality of lumens and the plurality of pushers are configured to cooperate to cause the plurality of resilient members to simultaneously move away from the insertion axis of each lumen when expelled into the target tissue.

PANCREATIC STENT WITH DRAINAGE FEATURE

A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.

TAPERED IMPLANTABLE DEVICE AND METHODS FOR MAKING SUCH DEVICES

METHOD FOR PRODUCING A CUSTOM PROSTHETIC SLEEVE

METHOD FOR PRODUCING A CUSTOM PROSTHETIC SLEEVE

Le procédé de fabrication d'un manchon prothétique sur mesure à partir d'une préforme thermoformable comprend : - fournir un moule positif réduit correspondant à la copie de la forme du moignon du membre résiduel réduite de 3 à 5% de l'ensemble des circonférences de la forme du moignon, - fournir une préforme à base d'un élastomère thermoformable, ladite préforme présentant une extrémité proximale ouverte, une extrémité distale fermée, une épaisseur de paroi uniforme et une dureté supérieure à 40 Shore A, préférentiellement supérieure à 42 Shore A, plus préférentiellement encore supérieure à 45 Shore A, - placer la préforme sur le moule positif réduit pour former un ensemble préforme/moule, - mettre en forme la préforme par chauffage de l'ensemble préforme/moule à une température comprise entre 60 et 150°C, préférentiellement entre 90°C et 120°C pour obtenir un manchon prothétique.

비외상성 스텐트 및 그를 제조하는 방법 및 장치

... 스텐트를 꼬는 방법은 필라멘트를 장력이 가해진 꼬임 캐리어에 감지 않고 장력이 가해진 꼬임 캐리어를 사용하여 맨드렐 주위로 다수의 기다란 필라멘트를 꼬아서 비외상성 단부를 갖는 꼬아진 스텐트를 형성하는 것을 포함한다.

ELECTROPOLISHING APPARATUS AND METHOD FOR MEDICAL IMPLANTS

An electropolishing apparatus and method are provided for polishing stents and other medical implants. The apparatus includes a motor that rotates a roller. The roller continuously rotates the medical implant to be electropolished. One of the advantages of the apparatus and method is that marks generated around the electrical contact between the anode and the medical implant are minimized. In addition, the medical implant is polished more evenly than conventional electropolishing systems.

SYSTEMS AND METHODS FOR MAKING ENCAPSULATED HOURGLASS SHAPED STENTS

Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary ...

HEART VALVE SEALING DEVICES AND DELIVERY DEVICES THEREFOR

In an exemplary method of implanting a valve repair device on a mitral valve of a patient, first and second clasps of the valve repair device are closed to grasp the leaflets of the mitral valve. First and second paddles of the valve repair device are closed to bring the leaflets of the mitral valve into contact with a coaption element.

PANCREATIC STENT WITH DRAINAGE FEATURE

A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.

Method for attaching radiopaque markers to a stent

A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis.

Biodegradable vascular filter

A vascular filter 20 comprises a support having stent struts 22 and a filtration portion having filtration struts 26. The support is arranged concentrically around the filtration portion. The filtration portion and support attach to form a filtration basket. The filtration portion is comprised of a material having a faster biodegradability rate than the support. Filtration portion and support may be biodegradable. The filtration portion may comprise a hub 24 to which the filtration struts connect, where the hubs rate of biodegradability may be the same or faster than that of the filtration struts. The vascular filter may be cut from a tube comprising inner and outer concentric portions, the inner portion may include a material having a faster rate of biodegradability than the outer portion. The inner and outer concentric portions may be at least partially spaced from one another radially, where connecting members possessing a faster biodegradability rate than the outer portion bridge a ...

Fracture fixation systems

Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days. The disclosed putties create an osteoconductive scaffold for bone regeneration and degrade over time to harmless 5 resorbable byproducts. Fixation devices for contacting an endosteal wall of an intramedullary (IM) canal of a fractured bone are also disclosed. One such fixation device includes a woven elongated structure fabricated from resorbable polymer filaments. The woven elongated structure has resilient properties that allow the woven 10 structure to be radially compressed and delivered to the IM canal using an insertion tube. When the insertion tube is removed, the woven structure expands towards its relaxed cross-sectional width to engage the endosteal wall. The woven elongated structure is impregnated with a resorbable polymer resin that cures in situ, or in the IM canal.

Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability

Bioprosthetic tissues and methods for making same, comprising fixing bioprosthetic implant tissue by treatment with 0.1 to 10 wt. % glutaraldehyde at elevated temperature, capping said fixed tissue by treatment with a diamine crosslinking agent, and treating said capped tissue with about 0.6 wt. % glutaraldehyde.

Method for reconstruction and augmentation of the breast

The invention provides a method for manufacturing a breast prosthesis, which method comprises the determination of existing contours of a breast of an individual in an upright position using magnetic resonance imaging (MRI) and/or 3D scanning with ultrasound (US), laser or photography, the planning of a moulage or virtual moulage using a computer-assisted modeling software, with or without a 3D visualization of a result to be expected, and the manufacturing of a customized breast prosthesis based on said moulage or said virtual moulage. The invention also provides for methods of breast reconstruction and/or augmentation.

Apparatus for attaching radiopaque markers to a stent

A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis.

Method for attaching radiopaque markers to a stent

A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis.

Apparatus, system, and method for intraocular lens power calculation using a regression formula incorporating corneal spherical aberration

An intraocular lens, and a system and method of providing an intraocular lens, having at least one characteristic of the intraocular lens customized in accordance with a modified regression that includes a modification for corneal spherical aberration. The lens, system and method may indicate measuring at least one biometric parameter of an eye at a desired light level, determining a desired postoperative condition of the eye, obtaining a corneal spherical aberration of the eye, applying at least one empirically derived regression calculation, and predictively estimating, in accordance with an output of the at least one empirically derived regression calculation, the at least one characteristic of the intraocular lens to obtain the desired postoperative condition. The empirically derived regression calculation includes at least a product of the corneal spherical aberration with an empirically derived corneal spherical aberration constant, and a mathematical indication of the at least one biometric parameter or one of the paraxial regression formulas commonly used in clinical practice to calculate IOL power in normal patients.

Method of making ophthalmic devices and components thereof from hydrophobic acrylic (ha) polymers with reduced or eliminated glistenings

This invention relates to the fields of polymer chemistry, materials science and ophthalmology. More particularly it relates to optical components and method(s) of preparing same from hydrophobic acrylic (HA) monomer(s) that exhibit reduced or eliminated glistenings when implanted in a patient's eye. The method of this invention uses a mixture of one or more low temperature initiators (LTI) combined with one or more high temperature initiators (HTI), to polymerize one or more HA monomers to produce an optical HA polymer which, when used to manufacture an optical component and implanted as with an intraocular lens (IOL), exhibit reduced glistenings to the patient.

Punching-based stent and its manufacturing method

The present invention is to provide a stent comprising a main body or at least a strut and a principal manufacturing method by means of one punching die for precision punching machining without a follow-up rolling & precision welding step in order to fulfill improved yield rate, mass production, effectively curtailed throughput time and manufacturing cost, and stent's lowered price benefiting more patients.

Stent fabrication via tubular casting processes

Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

Implant with a visual indicator of a barrier layer

An implantable soft tissue prosthesis device comprising a silicone elastomer-shell filled with silicone gel or liquid, which among the layers that constitute its shell includes a barrier layer formed of a low permeability silicone, which impedes the bleeding or diffusion of the silicone gel from the inside of the implant to its surroundings through the shell. This barrier layer is given a coloration different to the other layers of the shell, making it visible in the finished product. The coloration of the barrier layer gives the fabricator of the implant as well as to medical personnel, the possibility to identify the presence of the barrier layer and its homogeneity, improving the safety of the device.

Mesh enclosed tissue constructs

Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.

Correction of higher order aberrations in intraocular lenses

In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Systems and Methods for Determining Intraocular Lens Power

The present invention relates to devices, systems and methods for determination or selection of a lens power based on the postoperative vitreous length of an eye. The combined measurements of VL pre , ACD pre , AL, and/or LT are highly predictive in calculating the postoperative vitreous length, from which the position of the implanted intraocular lens or optic can be derived, and then selection of the appropriate lens power.

Fecal incontinence device, system and method

A device for treating fecal incontinence in a subject is provided. The device includes a plug configured for positioning mostly within an anal canal of the subject.

Lightweight breast implant material

A prosthetic implant material for use in a prosthetic implant, comprising a gel and optionally a gas.

Vascular remodeling device

Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.

Implantable medical device having enhanced endothelial migration features and methods of making the same

An implantable medical device having enhanced endothelial migration features, generally comprises: a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, and the trailing edge including a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.

Method and device for loading medical appliance with medicaments and/or polymers

A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

Electrode impedance spectroscopy

Aspects of the present invention are generally directed to impedance spectroscopy in an active implantable medical device (AIMD) comprising a component with one or more electrodes. In an embodiment, the AIMD applies a signal at a plurality of frequencies using one or more of the electrodes. Measurements are then obtained for the applied signal to determine impedance(s) at the applied frequencies of the tissue in which the electrodes are located.

Methods and apparatuses for vertebral body distraction and fusion employing a coaxial screw gear sleeve mechanism

Improved methods and apparatuses for vertebral body distraction and fusion in accordance with various embodiments of the present invention employ one or more coaxial screw gear sleeve mechanisms. In various embodiments, coaxial screw gear sleeve mechanisms include a post with a threaded exterior surface and a corresponding sleeve configured to surround the post, the corresponding sleeve having a threaded interior surface configured to interface with the threaded exterior surface of the post and a geared exterior surface. A drive mechanism can be configured to interface with the geared exterior surface of the sleeve, causing the device to distract.

Methods of making medical devices

Scaffold-supported metal or pseudometallic film covers suitable for use as medical devices are disclosed together with methods of fabricating the devices. Methods for making the medical devices consist of either providing or forming a scaffold, then depositing a metallic or pseudometallic film cover onto the scaffold in such a manner as to form an integral, substantially monolithic junction between the deposited cover material and the scaffold.

Methods For Modulating The Release Rate Of A Drug-Coated Stent

Methods for modulating the release rate of a drug coated stent are disclosed.

System, ophthalmic lens, and method for extending depth of focus

System, ophthalmic lens, and method for extending depth of focus includes an optic having a clear aperture disposed about a central axis. The optic includes a first surface and an opposing second surface. The first and second surfaces are configured to introduce an asymmetric aberration to the eye while maintaining the in-focus visual acuity.

Composite support containing silk and collagen, and preparation method thereof

Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation. Thus, the scaffold can be effectively used as a matrix for the regeneration of ligaments and tendons and the repair of injured muscles.

Adjustable Support For Tubular Medical Device Processing

An apparatus and method for supporting a tubular medical device, such as a stent or scaffold, includes a rod disposed between two collets. The rod can be shaped to form a range of different size or length helical supports to support a wide range of tubular medical devices. The rod is shaped into a full or partial helix by rotating one of the collets relative to the other.

Ultraviolet light absorbing materials for intraocular lens and uses thereof

A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 mm Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.

Hard-tissue implant

Hard-tissue implants are provided that include a bulk implant, a face, pillars, and slots. The pillars are for implantation into a hard tissue. The slots are to be occupied by the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 10 GPa, has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1, does not comprise any part that is hollow, and does not comprise any non-pillar part extending to or beyond the distal ends of any of the pillars. Methods of making and using hard-tissue implants are also provided.

Silk based implantable medical devices and methods for determining suitability for use in humans

Methods for determining suitability of an implantable silk scaffold for use in human soft tissue repair by implanting a silk scaffold in a quadruped. The silk scaffold is completely or essentially completely bioresorbed by twelve months after implantation, the silk scaffold (to the extent remaining) with ingrown tissue shows at least about a 60% strength increase by 12 months after implantation, and the thickness of the silk scaffold (to the extent remaining) with ingrown tissue increases by more than 100% by 12 months after implantation.

Method and device for modelling tendinous tissue into a desired shape

The present invention relates to methods and devices for the modelling tendinous tissue into a desired shape. The shaped tissue produced by the methods of the present invention is useful in any field relating to biological tissue, particularly in the field of medicine, most preferred in surgery, for intraoperative use or pre- or peri-operative preparation of the tissue.

Apparatus and method for stent shaping

An apparatus for crimping a radially expandable stent includes a pressure vessel, shaping balloon, and mandrel. The mandrel is configured to slidingly receive a stent thereon, and to be slidingly advanced into the pressure vessel. The shaping balloon is inflated to radially compress the stent onto the form of the mandrel; such compression need not be uniform. Pressurization of the shaping balloon facilitates the expansion of the balloon to achieve compression of the stent, with depressurization of the shaping balloon causing the balloon to return to an unexpanded state.

Round or anatomical type silicone prosthesis having shell with enhanced durability and method for manufacturing same

A silicone prosthesis including a silicone shell, which has superior texture and comfort when implanted in the body, minimizes stress concentration that may arise when wearing for a long time by eliminating the difference in physical characteristics and stress in all parts of the shell, due to the silicone prosthesis having a uniform thickness, increases resistance to fatigue fracture so as to maximize the safety and lifespan of the silicone prosthesis, and which controls the flow of the silicone in various angles, thereby providing a round or an anatomical type silicone prosthesis having a shell with enhanced durability and a uniform thickness.

Articles Including Expanded Polytetrafluoroethylene Membranes with Serpentine Fibrils and Having a Discontinuous Fluoropolymer Layer Thereon

Articles comprising an expanded polytetrafluoroethylene membrane having serpentine fibrils and having a discontinuous coating of a fluoropolymer thereon are provided. The fluoropolymer may be located at least partially in the pores of the expanded fluoropolymer membrane. In exemplary embodiments, the fluoropolymer is fluorinated ethylene propylene. The application of a tensile force at least partially straightens the serpentine fibrils, thereby elongating the article. The expanded polytetrafluoroethylene membrane may include a microstructure of substantially only fibrils. The articles can be elongated to a predetermined point at which further elongation is inhibited by a dramatic increase in stiffness. In one embodiment, the articles are used to form a covered stent device that requires little force to distend in the radial direction to a first diameter but is highly resistant to further distension to a second diameter (stop point). A large increase in diameter can advantageously be achieved prior to reaching the stop point.

Stent wires, and method for manufacturing such stent wires and stents

A method for manufacturing stent wires includes preparing three or more annular stent wires which has alternately arranged peaks and valleys, interconnecting the first and second stent wires, such that predetermined peaks of the second stent wire are caught in predetermined valleys of the first stent wire, passing a valley of a third stent wire below a free valley of the first stent wire and a free peak of the second stent wire, and interconnecting the third and second stent wires such that a peak of the third stent wire is caught in a valley of the second stent wire. The stent wires are connected in a stacked manner, thereby simplifying the manufacturing process, lengthening the lifespan of the stent wires, and improving the strength of the connection between two adjacent stent wires.

Polymers and methods for ophthalmic applications

The present invention relates to novel methods and materials particularly useful for ophthalmic applications and to methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and implanting IOLs made therefrom.

Hollow drug-filled stent and method of forming hollow durg-filled stent

A stent is formed from a wire having an outer member, a radiopaque member lining at least a portion of the outer member inner surface, and a lumen defined by the outer member inner surface or the radiopaque member inner surface. A substance is disposed in the lumen to be eluted through at least one opening disposed through the outer member to the lumen. The radiopaque member may be substantially continuous along the length of the wire or disposed only along portions of the wire such as crowns. In a method for making the stent, a composite wire including an outer member, a radiopaque intermediate member, and a core member is shaped into a stent pattern and processed to remove the core member and optionally portions of the radiopaque intermediate member, without damaging the outer member.

Implants And Procedures For Treatment Of Pelvic Floor Disorders

Implants for the treatment of pelvic support conditions and methods of implementing the same. The implants comprise relatively soft, flexible bodies and relatively strong arms extending in predetermined orientation therefrom. Methods and devices for placing the implants minimize trauma to the pelvic floor and provide well-anchored support to pelvic organs without interfering with sexual or other bodily functions.

Method for forming a stent

A method of forming a stent includes forming a wave form from a formable material. The wave form includes a plurality of substantially straight portions and a plurality of curved portions, each curved portion connecting adjacent substantially straight portions. The method includes wrapping the wave form around a mandrel at an angle to form a helical coil comprising a plurality of turns, connecting a first curved portion of a first turn to an adjacent second curved portion of a second turn at a position along the wave form to define an end of the stent, and removing excess material from an end of the wave form extending past the first curved portion while smoothing the end of the stent.

Glenoid implant

An apparatus can include a base plate. A glenosphere can be configured to be mountable to the base plate. The glenosphere can be adapted to operate with a complementary humeral component. The base plate can include a removable taper member on a side of the base plate facing the glenosphere. The taper member can be configured to mount the glenosphere to the base plate.

Apparatus and methods for filling a drug eluting medical device via capillary action

Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

Single plane tissue repair patch having a locating structure

A novel single plane tissue repair patch is disclosed. The patch has a base member with an opening therethrough, and a closure member associated with the opening. Mounted to the periphery of the bottom side of the base member is a locating structure. The mesh may be used in open surgical procedures for hernia repairs and other repairs of body wall defects.

Apparatus, systems and methods for medical device expansion

A system and method for manufacturing a medical device. The system can include a thermal chamber and an expander at least partially positioned within the thermal chamber. The expander can be configured to uniformly expand a medical device as the medical device is advanced over the heated expander and heat set the expanded medical device while the medical device is positioned on the heated expander. The method can include forming a medical device from a tube having a first diameter; uniformly expanding the medical device from the first diameter to a second diameter at which the medical device can be left within a body vessel, the medical device being expanded from the first diameter to the second diameter while being continuously positioned on an expander; and heat setting the expanded medical device at the second diameter while the medical device is positioned on the expander.

Suspension liner having multiple component system

A suspension liner for a residual limb has a liner body with a plurality of anterior and posterior projections formed from a thickness of the liner body. Medial and lateral tendons are located between and correspond to profiles of the plurality of the anterior and posterior projections such that the medial and lateral tendons are located on opposed sides of the liner body relative to one another. The medial and lateral tendons flare circumferentially toward proximal and distal sections of the liner body.

Compliant implantable medical devices and methods of making same

Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.

System and Method for Mapping Anatomical Structures and Marking Them on a Substrate

The present disclosure provides a method and system for mapping anatomical structures and marking them on an image to be printed on a substrate including the steps of inserting an imaging device into a surgical site, obtaining an image of a defect located in the surgical site from the imaging device, adjusting the image, transmitting the image to a printer, and printing the image on a substrate. The printed image may be a size directly proportional to the defect. The adjusting step may further include the steps of setting a minimum margin to be maintained between the perimeter of the defect and the perimeter of the substrate, selecting a shape and size of the substrate, and identifying at least one anatomical feature of the surgical site.

Implants for stress urinary incontinence treatments and related methods

An urogynecologic implant has a curved body that disperses force and reduces the ability of the urethra to expand into the pelvic floor under impulses of abdominal pressure in order to inhibit, reduce or prevent stress urinary incontinence.

Double bundle acl repair

A system for single tunnel, double bundle anterior cruciate ligament reconstruction includes implant constructs and instruments. The implant constructs provide a combination of cortical fixation and bone tunnel aperture fixation. The implant constructs separate a graft into distinct bundles. The instruments are used to prepare shaped bone tunnels to receive the implant constructs and graft bundles. Methods for reconstructing the antero-medial and postero-lateral bundles of the anterior cruciate ligament may rely on single femoral and tibial tunnels and a single strand of graft.

Radiopaque super-elastic intravascular stent

The intravascular stent is formed from a composite wire includes an inner core of radiopaque metal, a polymer layer coaxially disposed about the inner core, and an outer metal layer coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may be made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent has ends flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

Inflatable medical devices

An inflatable structure for use in biological lumens and methods of making and using the same are disclosed. The structure can have an inflatable balloon encircled by a shell. The shell can have proximal and distal tapered necks, longitudinally-oriented flutes, and apertures at the proximal and distal ends of the shell. The apertures can be recessed in the flutes in the necks. The shell can also have fiber reinforced walls.

Self-expanding devices and methods therefor

Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.

Breast implants with integrated transponders

The present invention provides, in various embodiments, a breast implant with an RFID transponder embedded therein, so that the implant can be conveniently identified while inside the human body, and methods of making the same.

Patient-specific intraluminal implants

Methods are provided for generating intraluminal prosthetic implants designed to fit onto specific anatomical locations within regions which are stable in terms of their motion in time.

KINK RESISTANT GRAFT

A kink resistant stent graft includes a graft forming a tube with a central lumen extending from a first end of the tube to a second end of the tube and a stent secured to the graft adjacent the first end of the tube. The graft includes a corrugated inner graft layer forming at least a middle portion of the tube, and an outer graft layer covering the corrugated inner graft layer. 1. A method of forming a kink resistant graft comprising:wrapping a film to form an inner graft layer forming a tube with a central lumen extending from a first end of the tube to a second end of the tube;scrunching the inner graft layer to form corrugations in the inner graft layer, the corrugations providing a stored length of the corrugated inner graft layer of at least twenty-five percent;wrapping an outer graft layer over the corrugated inner graft layer to cover the corrugated inner graft layer; andbonding the outer graft layer to the corrugated inner graft layer to form the kink resistant graft.2. The method of claim 1 , further comprising securing a stent to the graft adjacent the first end of the tube.3. The method of claim 1 , wherein wrapping the film to form the inner graft layer forming the tube includes wrapping more than one layer of the film to form the tube.4. The method of claim 1 , further comprising claim 1 , after wrapping the film to form the inner graft layer forming the tube and before scrunching the inner graft layer to form the corrugations in the inner graft layer claim 1 , heating the wrapped film to set the film in the tube.5. The method of claim 1 , further comprising claim 1 , after wrapping the outer graft layer over the corrugated inner graft layer to cover the corrugated inner graft layer claim 1 , bonding the wrapped outer graft layer to the corrugated inner graft layer.6. The method of claim 1 , wherein the kink resistant graft is configured to resist kinking while experiencing a 90 degree bend with an internal fluid pressure of at least 100 mmHg in that ...

Method and device for determining surface characteristics of stents, and stent defined surface characteristics

A method and a device that determines surface characteristics of a stent to be implanted in a lumen in a body in which a wetting behavior of a stent surface serves as measure for the surface characteristics of the stent surface. In order to determine the wetting behavior, a course of a wetting force along a length of the stent surface is determined, the wetting power between the stent surface and a liquid surface being detected along the length of the stent.

BIOABSORBABLE STENT SYSTEM

A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more restoration agents, wherein the one or more restoration agents are suitable for a targeting position and are coated on the surface of the bioabsorbable stent. A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more bioabsorbable films, wherein the bioabsorbable films are loaded with restoration agents and/or drugs suitable for a targeting position. 1. A bioabsorbable stent system comprising one or more bioabsorbable stents and one or more restoration agents , wherein the one or more restoration agents are suitable for a targeting position and are coated on the surface of the bioabsorbable stent.2. The bioabsorbable stent system of claim 1 , wherein the one or more bioabsorbable stents are coated with drugs suitable for the targeting position.3. The bioabsorbable stent system of claim 1 , wherein the one or more restoration agents comprise one or more of stem cells and its carrier claim 1 , epithelial cells and its carrier claim 1 , endothelial cells and its carrier claim 1 , cell growth factors and/or amniotic membrane.4. The bioabsorbable stent system of claim 1 , wherein the bioabsorbable stent comprises one or more bioabsorbable materials comprising one or more of magnesium claim 1 , magnesium alloys claim 1 , zinc alloy claim 1 , iron claim 1 , poly(N-acetylglucosamine) (Chitin) claim 1 , Chitosan claim 1 , poly(3-hydroxyvalerate) claim 1 , poly(lactide-co-glycolide) claim 1 , poly(3-hydroxybutyrate) claim 1 , poly(4-hydroxybutyrate) claim 1 , poly(3-hydroxybutyrate-co-3-hydroxyvalerate) claim 1 , polyorthoester claim 1 , polyanhydride claim 1 , poly(glycolic acid) claim 1 , poly(glycolide) claim 1 , poly(L-lactic acid) claim 1 , poly(L-lactide) claim 1 , poly(D claim 1 ,L-lactic acid) claim 1 , poly(D claim 1 ,L-lactide) claim 1 , poly(L-lactide-co-D claim 1 ,L-lactide) claim 1 , poly(caprolactone) claim 1 , poly(L-lactide-co- ...

AUTOMATED HEART VALVE SEWING

A system that can be used for suturing implants includes a first automated fixture that can comprise an articulation arm and a target device holder and a second automated fixture configured to operate as a sewing machine to sew material onto the implant. The second automated fixture uses a curved needle to form a stitch without having to release the needle in the process. The second automated fixture can also include a stitch looper that moves in coordination with the curved needle to perform a single-suture or single-thread stitch. 1. A method of suturing an implant device , the method comprising:disposing the implant device on a holder component of a first automated fixture;directing the first automated fixture to position the implant device in a first position;directing a second automated fixture to execute a first stitch on the implant device by passing a curved needle into and out of a material being sutured to the implant device;directing the first automated fixture to position the implant device in a second position; anddirecting the second automated fixture to execute a second stitch on the implant device by passing the curved needle into and out of the material being sutured to the implant device, the second automated fixture including a stitch looper that moves in coordination with the curved needle to form the first stitch and the second stitch.2. The method of claim 1 , wherein the implant device is a prosthetic heart valve.3. The method of claim 1 , further comprising directing the first automated fixture to circumferentially rotate the implant device in place.4. The method of claim 1 , further comprising loading a pre-programmed suturing procedure script using one or more processors configured to at least partially control the first automated fixture and the second automated fixture.5. The method of claim 1 , wherein the second automated fixture uses the curved needle to execute the first stitch such that the first stitch is a single suture stitch.6. ...

Annuloplasty Ring Holder

An annuloplasty ring holder including a head having an upper surface and an annuloplasty ring receiving surface facing opposite the upper surface. The annuloplasty ring holder also includes means for attaching an annuloplasty ring to the annuloplasty ring receiving surface. The means for attaching an annuloplasty ring to the annuloplasty ring receiving surface may include one or more suture guides operatively associated with the head and configured to position one or more sutures to removably associate an annuloplasty ring with the annuloplasty ring receiving surface. The head may include a central hub and more than one spoke radiating out from the central hub. If the head is thus configured, each spoke will include a portion of the annuloplasty ring receiving surface. 1. A method of attaching an annuloplasty ring to an annuloplasty ring holder comprising:providing an annuloplasty ring holder;attaching an annuloplasty ring to the annuloplasty ring holder with one or more sutures such that the annuloplasty ring may be released from the annuloplasty ring holder by severing once a single suture of the one or more sutures, without severing any other suture of the one or more sutures.2. The method of attaching an annuloplasty ring to an annuloplasty ring holder of further comprising attaching each of the one or more sutures to the annuloplasty ring holder.3. The method of attaching an annuloplasty ring to an annuloplasty ring holder of further comprising attaching the annuloplasty ring to the annuloplasty ring holder with a continuous single length of suture.4. An annuloplasty ring and holder comprising:an annuloplasty ring holder;an annuloplasty ring; andone or more sutures associating the annuloplasty ring with the annuloplasty ring holder such that the annuloplasty ring holder may be disassociated from the annuloplasty ring by severing a single suture of the one or more sutures once, and severing no other sutures of the one or more sutures.5. The annuloplasty ring and ...

Spinal implant and methods of manufacture thereof

Disclosed herein is an invertebral disc prosthesis comprising a first cantilever arm; the first cantilever arm comprising a shaft that is affixed to a disc; a second cantilever arm that comprises a plurality of rods that contact the disc; the plurality of rods being equidistant from a central axis of the shaft; and a third cantilever arm that comprises a platform to which are attached a plurality of rings; the rings being concentrically disposed about the shaft; the rings being in operative communication with each other; where the plurality of rods contacts the platform; and where the second cantilever arm has more degrees of freedom than the first cantilever arm, while the third cantilever arm has a number of degrees of freedom that are greater than or equal to the number of degrees of the second cantilever arm.

Gender specific pharmaceuticals

The present disclosure provides a system of gender specific pharmaceuticals. The system includes a first package of a pharmaceutical for use by a male and a second package of a pharmaceutical for use by a female. The first package includes a pharmaceutical for use by a male and a first label coupled to the first package, wherein at least one of the first package and first label includes a male specifier and a recommended male dosage. The second package includes a pharmaceutical for use by a female and a second label coupled to the second package, wherein at least one of the second package and second label includes a female specifier and a recommended female dosage.

MASKED INTRAOCULAR IMPLANTS AND LENSES

Intraocular implants and methods of making intraocular implants are provided. The intraocular implants can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. In particular, the intraocular implants can include a mask having an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion such as a clear lens or aperture. This construct is adapted to provide an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The intraocular implant may have an optical power for refractive correction. The intraocular implant may be implanted in any location along the optical pathway in the eye, e.g., as an implant in the anterior or posterior chamber. 1. (canceled)2. A method of enhancing depth of focus of a patient , the method comprising:creating an incision in an eye of the patient;implanting an implant body through the incision in the eye of the patient, the implant body comprising a lens body;after implanting the implant body through the incision in the eye, forming an opaque mask onto the lens body, the opaque mask comprising an aperture sized to enhance depth of focus.3. The method of claim 2 , wherein forming the opaque mask comprises printing the opaque mask.4. The method of claim 2 , wherein forming the opaque mask comprises laser etching the opaque mask.5. The method of claim 2 , wherein forming the opaque mask comprises forming the opaque mask onto a surface of the lens body.6. The method of claim 5 , wherein the surface is an anterior surface of the lens body.7. The method of claim 5 , wherein the surface is a posterior surface of the lens body.8. The method of claim 2 , wherein forming the opaque mask comprises forming the opaque mask within the lens body.9. The method of claim 2 , wherein implanting the implant body comprises implanting the lens body within a lens capsule of the eye.10. The method of claim 2 ...

TRUNCATED LEAFLET FOR PROSTHETIC HEART VALVES

Described embodiments are directed toward prosthetic valves having leaflets of a particular shape that improves bending character without requiring a long length valve. In accordance with an embodiment, a prosthetic valve comprises a leaflet frame, a plurality of leaflets that are coupled to the leaflet frame, where each leaflet has a free edge and a base. The base of each leaflet is truncated in which the leaflet in cross section shows a line in an alpha plane onto the leaflet frame. 120.-. (canceled)21. A prosthetic valve having an inflow end and an outflow end , the prosthetic valve comprising:a frame assembly having a central longitudinal axis and including a leaflet frame and a cover having a generally tubular shape, the cover being coupled to the leaflet frame such that the cover at least partially covers the leaflet frame; anda plurality of leaflets coupled to the frame assembly, each leaflet including a leaflet free edge configured to abut an adjacent leaflet free edge when the plurality of leaflets transition from an open position to a closed position to stop fluid flow through the prosthetic valve, a first leaflet side coupled to the frame assembly, a second leaflet side coupled to the frame assembly, and a leaflet base coupled to the frame assembly, the leaflet base being positioned opposite the leaflet free edge and being flat in a plane transverse to the central longitudinal axis of the frame assembly.22. The prosthetic valve of claim 21 , wherein the leaflet frame includes a plurality of commissure posts and each leaflet base of the plurality of leaflets is located inferior and exterior to a line joining apices of two adjacent commissure posts of the leaflet frame.23. The prosthetic valve of claim 21 , wherein the leaflet bases of each of the plurality of leaflets are attached to the frame assembly along a straight line.24. The prosthetic valve of claim 21 , wherein the leaflet frame has a tubular shape.25. The prosthetic valve of claim 21 , wherein ...

SYSTEM AND METHOD FOR IMPLANTING AND SECURING A BIOPROSTHETIC DEVICE TO WET TISSUE

Systems, devices, kits, and methods are described for securing a bioprosthetic heart valve within an anatomical feature of a patient. Kits can comprise a bioprosthetic heart valve, a curable composition, and an applicator configured to deliver the curable composition to a target area. The bioprosthetic heart valve can comprise a support structure and one or more valve leaflets coupled thereto. The support structure can comprise a sewing portion peripheral of the bioprosthetic heart valve. The support structure and the valve leaflets can define a central flow orifice. The curable composition can comprise a pre-polymer composition and an initiator. Methods can comprise positioning the bioprosthetic heart valve within the anatomical feature of a patient, applying the curable composition to one or both of the bioprosthetic heart valve and the anatomical feature, and curing the curable composition for a cure time. The applying can be performed before or after the positioning. 1. A method for implanting an implant device to an anatomical feature of a patient , the method comprising:positioning the implant device at an implant location inside the patient's body;applying a curable composition to one or both of the implant device and an anatomical feature, the curable composition comprising a pre-polymer composition and an initiator; andcuring the curable composition for a cure time after the applying step;wherein the applying step is performed either before or after the positioning.2. The method of claim 1 , wherein the implant device is selected from the group consisting of: a bioprosthetic heart valve and an annuloplasty ring.3. The method of claim 1 , wherein the implant device is a bioprosthetic heart valve and wherein the heart valve comprises a support structure and one or more valve leaflets coupled to the support structure and wherein the support structure defines a central flow orifice.4. The method of claim 3 , wherein the bioprosthetic heart valve further ...

SYNTHETIC IMPLANT DEVICE REPLICATING NATURAL TISSUE STRUCTURE AND METHODS OF MAKING SAME

A composite implant device for use in a medical application, comprising a synthetically-derived mesh that mimics particular critical aspects of a biologically-derived mesh. The composite implant device can be used for the reinforcement and reconstruction of tissues within the body and can be comprised of a majority of synthetic components and minority of naturally-derived components which mimic the structure and function of a naturally-derived mesh. 1. A multilayer construct , the construct comprising:a. a base layer comprising a synthetic polymer;b. a first fibrous layer adjoined directly to the base layer;c. a second fibrous layer adjoined directly to the first fibrous layer, wherein the first and second fibrous layers have non-identical properties.2. The construct of wherein the base layer is bioresorbable.3. The construct of wherein the base layer is in the form of a sheet and does not contain pores.4. The construct of wherein the base layer has a strain-at-break of 100-2500%.5. The construct of wherein the base layer comprises a colorant.6. The construct of wherein the first layer comprises fibrous elements having a fiber diameter claim 1 , wherein the fiber diameter is 0.001-1 mm.7. The construct of wherein the first layer comprises electrospun fibers.8. The construct of wherein the first layer is bioabsorbable9. The construct of wherein the base layer is elastomeric and the first layer is elastomeric.10. The construct of wherein a deforming load of 100% strain-at-break does not cause delamination of the base layer from the first layer.11. The construct of wherein a copolyester is present in both the base layer and the first layer.12. The construct of wherein the second layer comprises fibrous elements having a fiber diameter claim 1 , wherein the fiber diameter is 0.001-1 mm.13. The construct of wherein the second layer comprises electrospun fibers.14. The construct of wherein a copolyester is present in the base layer claim 1 , the first layer and the second ...

Implant with Elastomeric Membrane and Methods of Fabrication Thereof

A method of forming an implant includes providing a preformed shell formed from at least one cured elastomeric layer. The preformed shell includes an outer surface, an inner surface, and an opening for accessing an interior volume of the preformed shell. The method further includes expanding the preformed shell to an expanded state, in which the interior volume is greater than the interior volume of the preformed shell at a time of forming the preformed shell and forming an inner zone having at least one inner elastomeric layer on at least a portion of the inner surface of the preformed shell, while the shell is in the expanded state, thereby forming a multi-zone shell. The method further includes reducing the interior volume of the multi-zone shell, thereby contracting the at least one inner elastomeric layer of the inner zone and causing texturing of the at least one inner elastomeric layer. 1. A method of forming an implant for volumetrically altering , replacing , expanding , or augmenting body tissues , the method comprising:providing a preformed shell formed from at least one cured elastomeric layer, the preformed shell comprising an outer surface, an inner surface, and an opening for accessing an interior volume of the preformed shell;expanding the preformed shell to an expanded state, in which the interior volume is greater than the interior volume of the preformed shell at a time of forming the preformed shell;forming an inner zone comprising at least one inner elastomeric layer on at least a portion of the inner surface of the preformed shell, while the shell is in the expanded state, thereby forming a multi-zone shell;reducing the interior volume of the multi-zone shell, thereby contracting the at least one inner elastomeric layer of the inner zone and causing texturing of the at least one inner elastomeric layer; andforming the implant by enclosing the multi-zone shell to form at least one chamber.2. The method of claim 1 , wherein expanding the ...

Heart valve sealing devices and delivery devices therefor

An exemplary implantable prosthetic device has a paddle frame, an inner paddle, and an outer paddle. The outer paddle is connected to the inner paddle. The inner and outer paddles are connected to the paddle frame at a connection between the inner paddle and the outer paddle. The paddle frame can be positioned inside the inner paddle, outside the outer paddle, or between the inner and outer paddles.

SPIRAL-BASED THIN-FILM MESH SYSTEMS AND RELATED METHODS

A spiral-based thin-film mesh for medical devices and related methods is provided. The spiral-based thin-film mesh may be used as a stent cover for a stent device. The thin-film mesh may include a plurality of spirals. The spirals allow the thin-film mesh to expand omni-directionally. In one or more embodiments, the spirals may be logarithmic spirals, golden spirals, approximated golden spirals, box Phi spirals, or Fibonacci spirals. The thin-film mesh may be formed from thin-film Nitinol (TFN), and may be fabricated via sputter deposition on a micropattemed wafer. 1. A thin-film mesh device comprising:a thin-film mesh that comprises a plurality of spirals that are omni-directionally expandable.2. The thin-film mesh device of claim 1 , wherein the plurality of spirals is arranged around an approximate central point on the thin-film mesh.3. The thin-film mesh device of claim 1 , wherein each of the spirals comprises one of three spiral arms claim 1 , four spiral arms claim 1 , six spiral arms claim 1 , twelve spiral arms claim 1 , or twenty-four spiral arms.4. The thin-film mesh device of claim 1 , wherein claim 1 , for each of the spirals claim 1 , a distance between adjacent spiral arms increases as the spiral arms radiate out from a center of the spiral.5. The thin-film mesh device of claim 1 , wherein the thin-film mesh further comprises a plurality of triangular interconnects claim 1 , wherein each of the triangular interconnects connects three of the spirals with one another.6. The thin-film mesh device of claim 1 , wherein each of the spirals is one of a logarithmic spiral claim 1 , a golden spiral claim 1 , an approximated golden spiral claim 1 , a box Phi spiral claim 1 , or a Fibonacci spiral.7. The thin-film mesh device of claim 6 , wherein the box Phi spiral is one of a two box Phi spiral claim 6 , a three box Phi spiral claim 6 , or a four box Phi spiral.8. The thin-film mesh device of claim 1 , wherein the thin-film mesh comprises thin-film Nitinol (TFN ...

PROSTHETIC HEART VALVE COMPOSED OF COMPOSITE FIBERS

A prosthetic heart leaflet includes a fiber-reinforced structure including a plurality of composite fibers. Each composite fiber includes a core fiber and a sheathing fiber disposed about the core fiber, wherein the core fiber or the sheathing fiber has a curvilinear shape. 1. A prosthetic heart valve leaflet comprising a fiber-reinforced structure including a plurality of composite fibers , each composite fiber comprising a core fiber and a sheathing fiber disposed about the core fiber , wherein the core fiber or the sheathing fiber has a curvilinear shape.2. The prosthetic heart valve leaflet of claim 1 , wherein the sheathing fiber has the curvilinear shape claim 1 , the sheathing fiber being spirally disposed about the core fiber.3. The prosthetic heart valve leaflet of claim 1 , wherein the sheathing fiber helically wraps around a longitudinal axis defined by the composite fiber.4. The prosthetic heart valve leaflet of claim 1 , wherein a ratio of core diameter to sheathing fiber diameter ranges from about 1:1 to 1:2.5. The prosthetic heart valve leaflet of claim 1 , wherein weight ratio of the core fiber to the sheathing fiber ranges from 1:5 to 5:1.6. The prosthetic heart valve leaflet of claim 1 , wherein the core fiber and the sheathing fiber are made of different polymeric materials.7. The prosthetic heart valve leaflet of claim 1 , wherein the core fiber comprises an elastomer and the sheathing fiber comprises a thermoplastic polymer.8. The prosthetic heart valve leaflet of claim 1 , wherein the core fiber comprises a tensile modulus that is greater than a tensile modulus of the sheathing fiber.9. The prosthetic heart valve leaflet of claim 1 , wherein the core fiber or the sheathing fiber comprises carbon fillers.10. The prosthetic heart valve leaflet of claim 1 , wherein the composite fiber includes a coating comprising polyethylene glycol.11. The prosthetic heart valve leaflet of claim 1 , wherein the composite fiber comprises at least two sheathing ...

APPARATUS FOR AUTOMATICALLY SEPARATING HAIR FOLLICLES

An apparatus for automatically separating hair follicles includes a follicle separating unit configured to cut a skin tissue of a scalp cut from a back of a head of an alopecic patient in units of follicles and to classify follicles by a number of hairs included in each follicle in an incisional hair transplant or to classify follicles each directly extracted from the back of the head of the alopecic patient by the number of hairs included in each follicle in a non-incisional hair transplant, and a follicle separation control unit configured to control an operation of the follicle separating unit. 1. An apparatus for automatically separating hair follicles , the apparatus comprising: to cut a skin tissue of a scalp cut from a back of a head of an alopecic patient in units of follicles and to classify follicles by a number of hairs included in each follicle in an incisional hair transplant, or', 'to classify follicles each directly extracted from the back of the head of the alopecic patient by the number of hairs included in each follicle in a non-incisional hair transplant; and', 'a follicle separation control unit configured to control an operation of the follicle separating unit., 'a follicle separating unit configured'}2. The apparatus according to claim 1 , further comprising a first monitor unit including a first display claim 1 , wherein claim 1 , in the incisional hair transplant claim 1 ,the follicle separating unit is configured to collect information and Figures on a scalp image obtained by scanning the scalp,the follicle separation control unit is configured to perform a datafication of the information and Figures on the scalp image collected by the follicle separating unit and to output dataficated information and Figures on the scalp image to the first monitor unit andthe first monitor unit is configured to display the dataficated information and Figures on the scalp image outputted from the follicle separation control unit on the first display.3. The ...

METHOD FOR PRODUCING SPACERS AND DEVICE THEREFOR

The invention relates to a method for producing spacers from a bone cement comprising the following chronological steps: 1. Method for producing spacers from a bone cement , comprising the chronological steps of:A) controlling the temperature of a casting mould to a first temperature;B) filling a cement dough, which has a temperature that is lower than the temperature of the temperature-controlled casting mould, into the temperature-controlled casting mould;C) allowing the cement dough to cure in the casting mould to form a spacer; andD) separating the casting mould from the spacer after the spacer is cured.2. Method according to claim 1 , wherein said cement dough is made of polymethylmethacrylate claim 1 , and the spacer thus produced is formed of polymethylmethacrylate.3. Method according to claim 1 , wherein at least the surface of the casting mould forming the spacer to is comprised of at least 90% claim 1 , of a non-elastic material.4. Method according to claim 1 , wherein the cement dough is filled into the temperature-controlled casting mould while it has a temperature at least 10° C. lower than the first temperature of the temperature-controlled casting mould.5. Method according to claim 1 , wherein the casting mould is temperature-controlled to a first temperature between 40° C. and 65° C.6. Method according to claim 1 , wherein the cement dough being filled into the casting mould has a temperature between −30° C. and 30° C.7. Method according to claim 1 , wherein the cement dough is brought to a temperature lower than the first temperature of the temperature-controlled casting mould before filling it into the casting mould.89. Method according to claim 1 , wherein the cement dough being filled into the casting mould has a volume that is at least 2% by volume larger than the mould cavity claim 1 , whereby the additional volume is present in a sprue () of the casting mould at least before the bone cement is cured.9. Method according to claim 1 , wherein at ...

APPARATUS AND METHOD FOR PRODUCING A BIOCOMPATIBLE THREE-DIMENSIONAL OBJECT

An apparatus for making a biocompatible three-dimensional object including at least one delivery unit arranged to deliver at least one biocompatible fluid substance towards a 3D mold having a matrix surface to obtain a coating layer of a predetermined thickness configured for coating the matrix surface. The three-dimensional object may be a heart valve. Furthermore, a handling unit is provided arranged to provide a relative movement according to at least 3 degrees of freedom between the 3D mold and each delivery unit. The 3D mold is arranged to be coated by the delivered biocompatible fluid substance, in order to obtain a three-dimensional object having an object surface copying the matrix surface of the support body. 1. A method for making a biocompatible three-dimensional heart valve , the method comprising the steps of:delivering at least one biocompatible fluid substance towards a mold having a mold surface to obtain a coating layer of predetermined thickness configured for coating the mold surface, using at least one delivery unit, the biocompatible fluid substance including a plurality of particles;handling with a handling unit the mold and the delivery unit in order to provide a relative movement with at least three degrees of freedom between the mold and the delivery unit, the mold coated with the at least one biocompatible fluid substance that is delivered to obtain a three-dimensional heart valve having a surface corresponding to the mold surface;removing from the mold any surplus particles of the at least one biocompatible fluid substance dispensed using a suction and blowing device in order to make uniform the predetermined thickness of the coating layer; andpressing a counter mold on the coating layer deposited on the mold after delivering the biocompatible fluid substance.2. The method of claim 1 , further comprising determining a size and geometry of the heart valve.3. The method of claim 2 , wherein determining the size of the heart valve is achieved ...

COMPOSITIONS, SYSTEMS AND METHODS FOR PATIENT SPECIFIC OPHTHALMIC DEVICE

Systems, methods, and devices to fabricate one or more device components are disclosed. An example method includes fabricating one or more subject specific device components generated from receiving one or more images of one or more features of the first eye of the subject; designing a three dimensional virtual geometric model of the ophthalmic device using the one or more images; generating a plurality of virtual cross-sections of the three-dimensional virtual geometric model, wherein the cross-sections are defined by a set of physical parameters derived from the three-dimensional model; and fabricating the one or more subject specific features using the plurality of virtual cross-sections of the three dimensional model to direct an additive manufacturing method. 1. A method for generating an ophthalmic device for a first eye of a subject , the method comprising:a. receiving one or more images of one or more features of the first eye of the subject;b. designing a three dimensional virtual geometric model of the ophthalmic device using the one or more images;c. generating a plurality of virtual cross-sections of the three-dimensional virtual geometric model, wherein the cross-sections are defined by a set of physical parameters derived from the three-dimensional model;d. fabricating the ophthalmic device using the plurality of virtual cross-sections of the three dimensional model to direct an additive manufacturing method.2. The method of claim 1 , wherein the receiving one or more images of the one or more features of the eye of a subject further comprises use of ultrasound claim 1 , bio-microscopy claim 1 , optical coherence tomography claim 1 , tomography claim 1 , magnetic resonance imaging claim 1 , computed tomography scanning claim 1 , light microscopy claim 1 , photoacoustic microscopy claim 1 , wave-front sensing claim 1 , corneal tomography claim 1 , biometry claim 1 , intraocular biometry or fundus photography to generate the one or more images.3. The ...

Devices and methods for anatomic mapping for prosthetic implants

A method of generating a patient-specific prosthetic includes receiving anatomic imaging data representative of a portion of a patient's anatomy. A first digital representation of the anatomic imaging data is defined. The first digital representation of the anatomic imaging data is modified. A second digital representation of the portion of the patient's anatomy is defined based on the modifying of the first digital representation of the anatomic imaging data. A patient-specific prosthetic template of the portion of the patient's anatomy is generated based at least in part on the second digital representation of the anatomic imaging data.

DIFFRACTIVE LENSES AND RELATED INTRAOCULAR LENSES FOR PRESBYOPIA TREATMENT

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for reducing dysphotopsia effects, such as straylight, haloes and glare, in diffractive lenses. Exemplary ophthalmic lenses can include a diffractive profile that distributes light among a near focal length, a far focal length, and one or more intermediate focal length. The diffractive profile provides for minimized or zero step heights between one or more pairs of diffractive zones for reducing visual artifacts. 1. An ophthalmic lens , comprising:a first surface and a second surface disposed about an optical axis; and the diffractive profile includes a repetitive pattern of at least two echelettes; and', 'at least one of the at least two echelettes in the repetitive pattern is connected to an adjacent echelette by a step height of zero., 'a diffractive profile imposed on one of the first surface or the second surface, wherein2. The lens of claim 1 , wherein the repetitive pattern is of three echelettes.3. The lens of claim 2 , wherein the lens is a quadrifocal lens.4. The lens of claim 1 , wherein the lens is a trifocal lens.5. The lens of claim 1 , wherein the lens is an extended depth of focus lens.6. The lens of claim 1 , wherein the lens is a monofocal lens.7. The lens of claim 1 , wherein the diffractive profile covers an area of the first surface or the second surface.8. The lens of claim 1 , wherein the diffractive profile covers an annulus of the first surface or the second surface.9. The lens of claim 1 , wherein the diffractive profile creates at least one focal point.10. The lens of claim 9 , wherein the diffractive profile creates at least two focal points.11. The lens of claim 1 , wherein the diffractive profile is operable to reduce optical aberration at the far focal length.12. The lens of claim 1 , wherein the repetitive pattern includes a form of apodization.13. An ophthalmic lens claim 1 , comprising:a first surface ...

Prosthetic Lenses and Methods of Making the Same

An optical device comprising a lens configured to be disposed in an eye. The lens is configured to contact a sclera of the eye and have a clearance above a cornea of the eye when disposed in the eye. The lens comprises a back surface that comprises at least one non-symmetrical feature that is configured to engage a corresponding feature on the eye. The lens is configured to be rotationally stable in use based on the at least one non-symmetrical feature on the back surface of the lens. 1. An optical device comprising:a lens configured to be disposed on an eye,wherein the lens is configured to contact a sclera of the eye and have a clearance above a cornea of the eye when disposed on the eye,wherein the lens comprises a back surface,wherein the back surface comprises at least one non-symmetrical feature that is configured to engage a corresponding feature on the eye, andwherein the lens is configured to be rotationally stable in use based on the at least one non-symmetrical feature on the back surface of the lens.2. The optical device of claim 1 , wherein the corresponding feature on the eye comprises a protrusion or a deformation claim 1 , and wherein the at least one non-symmetrical feature on the back surface of the lens comprises a bump zone configured to provide a clearance from the back surface of the lens to the protrusion or the deformation.3. The optical device of claim 1 , wherein the at least one non-symmetrical feature on the back surface of the lens comprises a non-symmetric contour configured to follow a contour of the sclera of the eye.4. The optical device of claim 1 , wherein the back surface of the lens is determined according to an optic zone of the eye located within a limbal perimeter of the eye claim 1 , a transition zone adjacent to the optic zone claim 1 , a landing zone adjacent to the transition zone claim 1 , and an edge lift zone adjacent to the landing zone.5. The optical device of claim 1 , wherein the lens further comprises a front ...

Prosthetic Lenses and Methods of Making the Same

An optical device comprising a lens configured to be disposed in an eye. The lens is configured to contact a sclera of the eye and have a clearance above a cornea of the eye when disposed in the eye. The lens comprises a back surface that comprises at least one non-symmetrical feature that is configured to engage a corresponding feature on the eye. The lens is configured to be rotationally stable in use based on the at least one non-symmetrical feature on the back surface of the lens. 1. An apparatus comprising: a front lens surface;', 'a back lens surface; and', 'an optical axis, and, 'a lens configured to be disposed on an eye, wherein the lens compriseswherein the optical axis is not aligned with a corneal apical axis of the eye.2. The apparatus of claim 1 , wherein the lens comprises a scleral cover shell.3. The apparatus of claim 1 , wherein the lens comprises a decentered optical design.4. The apparatus of claim 1 , wherein the lens comprises an independent elevation specific design.5. The apparatus of claim 1 , wherein the back lens surface is determined according to an optic zone of the eye located within a limbal perimeter of the eye claim 1 , a transition zone adjacent to the optic zone claim 1 , a landing zone adjacent to the transition zone claim 1 , and an edge lift zone adjacent to the landing zone.6. The apparatus of claim 1 , wherein the front lens surface is determined according to an optic zone of the eye located within a limbal perimeter of the eye claim 1 , a transition zone adjacent to the optic zone claim 1 , a landing zone adjacent to the transition zone claim 1 , and an edge lift zone adjacent to the landing zone.7. The apparatus of claim 1 , wherein the front lens surface is determined according to the back lens surface.8. A method of manufacturing a lens for disposition on an eye claim 1 , comprising:identifying a corneal apical axis of the eyecalculating characteristics of a back surface of the lens having an optical axis not aligned with ...

Device for Heart Repair

Disclosed herein is an anchor system for implantation in body tissue to hold a line (). The anchor system comprises an anchor (), the anchor () comprising a number of hooks () for engagement with the body tissue and having a folded configuration and an unfolded configuration. The anchor () is made of an elastic material such that it can be elastically deformed into the folded configuration by application of a constraining force, and will return to the unfolded configuration when no constraining force is applied. The end of each of the hooks () comprises a tip (′), wherein the tips (′) are formed to curve towards a central axis of the anchor () when the anchor () is in the folded configuration. 1. An anchor system for implantation in body tissue to hold a line , the anchor system comprising:an anchor comprising a number of hooks for engagement with the body tissue and having a folded configuration and an unfolded configuration, wherein the anchor is made of an elastic material such that it can be elastically deformed into the folded configuration by application of a constraining force, and will return to the unfolded configuration when no constraining force is applied, and wherein the end of each of the hooks comprises a tip, and wherein the tips are formed to curve towards a central axis of the anchor when the anchor is in the folded configuration.2. An anchor system as claimed in claim 1 , wherein each hook has at least one point of inflection in its curvature.3. An anchor system as claimed in or claim 1 , wherein the curvature of each tip is such that in the folded configuration each tip is configured to be 0 to 30 degrees to the normal of the surface of body tissue the anchor is to be implanted in.4. An anchor system as claimed in claim 1 , or claim 1 , further comprising a container device for applying the constraining force claim 1 , the container device housing the anchor in its folded configuration.5. An anchor system as claimed in claim 4 , wherein the ...

Breast Prostheses, Methods of Manufacturing Breast Prostheses, and Methods of Treatment Using Breast Prostheses

Improved breast prostheses, methods of making breast prostheses, and methods of treatment using such breast prostheses are described. 119-. (canceled)20. A breast prosthesis comprising:a tissue expander or a breast implant; andone or more samples of graft material, wherein the one or more samples of graft material are attached to the tissue expander or breast implant with an adhesive that degrades over time, and wherein the graft material comprises an extracellular tissue matrix.21. The breast prosthesis of claim 20 , wherein the adhesive comprises a synthetic adhesive.22. The breast prosthesis of claim 21 , wherein the synthetic adhesive comprises at least one of silicone or poly(methyl methacrylate).23. The breast prosthesis of claim 20 , wherein the adhesive comprises a biologically derived adhesive.24. The breast prosthesis of claim 23 , wherein the biologically derived adhesive comprises a marine adhesive.25. The breast prosthesis of claim 20 , wherein the extracellular tissue matrix has been treated to produce a three-dimensional porous or sponge-like material.26. The breast prosthesis of claim 20 , wherein the tissue expander or breast implant comprises a saline filled implant.27. The breast prosthesis of claim 20 , wherein the tissue expander or breast implant comprises a silicone gel implant.28. The breast prosthesis of claim 20 , wherein the graft material comprises an acellular tissue matrix.29. The breast prosthesis of claim 28 , wherein the acellular tissue matrix comprises a dermal tissue matrix.30. The breast prosthesis of claim 28 , wherein the acellular tissue matrix comprises an adipose tissue matrix.31. A method of making a breast prosthesis comprising:selecting a tissue expander or a breast implantselecting one or more samples of graft material comprising an extracellular tissue matrix; andattaching the one or more samples of graft material to the tissue expander or breast implant with an adhesive that will degrade over time when implanted in ...

Implantable device for the locationally accurate delivery and administration of substances into the pericardium or onto the surface of the heart

The present invention relates to a device for the administration of substances onto the epicardial surface of the heart. The device comprises a frame structure which is able to assume shaping, positioning, guiding and stabilizing functions. The frame structure may contain at least one sleeve. The device comprises a substance carrier which is able to accommodate the substance to be administered.

FLEXIBLE PROSTHETIC BEARING FOR JOINT

A bearing for a total or partial joint replacement prosthesis: the bearing having a body and a reinforcing element which strengthens the bearing and which forms an attachment member, and/or the bearing being formed at least partially from polymeric or composite material the bearing comprising a lower modulus portion and a higher modulus portion, one portion of the bearing being at least partially encased by the other portion of the bearing. Also provided is a method for of forming the bearing, and a total or partial joint replacement prosthesis comprising the hearing. 1. A bearing for a total or partial joint replacement prosthesis , the bearing having a body and a reinforcing element which strengthens the bearing and which forms an attachment member , wherein the attachment member is configured to be attached to a total or partial joint replacement prosthesis.2. The bearing as claimed in claim 1 , wherein the reinforcing element is partially within the body claim 1 , and extends out of the body to form the attachment member.3. The bearing as claimed in claim 1 , wherein the reinforcing element comprises a fibre.4. The bearing as claimed in claim 1 , wherein the reinforcing element comprises a plurality of fibres.5. The bearing as claimed in claim 4 , wherein the fibres are woven together to form the attachment member.6. The bearing as claimed in claim 4 , wherein the fibres are moulded or adhered together to form the attachment member.7. The bearing as claimed in claim 1 , wherein the attachment member comprises a loop.8. The bearing as claimed in claim 1 , wherein the attachment member is configured to be attached to a clip.9. The bearing as claimed in claim 1 , wherein the attachment member is configured to be attached to bone or soft tissue.10. The bearing as claimed in claim 1 , wherein the bearing comprises a plurality of attachment members.11. The bearing as claimed in claim 3 , wherein the fibre forms a mesh which permeates the body.12. The bearing as ...

PROSTHETIC DIGIT FOR USE WITH TOUCHSCREEN DEVICES

A digit for a prosthetic hand is provided. The digit has a base member () attachable to the hand and at least one digit member () pivotably connected to the base member. The at least one digit member () has a digit tip () remote from the base member (), and the digit member is at least partially covered with at least one conductive substance () which defines a conductive path which leads from the digit tip towards the base member. A method of manufacturing such a digit is also provided. 1. A digit for a prosthetic hand , the digit comprising:a base member attachable to the hand; andat least one digit member pivotably connected to the base member;wherein the at least one digit member has a digit tip remote from the base member, and the digit member is at least partially covered with at least one conductive substance which defines a conductive path which leads from the digit tip towards the base member.2. The digit of claim 1 , further comprising a cover adapted to fit over at least the digit tip claim 1 , the cover having a cover tip which lies over the digit tip when the cover is in place claim 1 , wherein the cover tip includes at least one aperture extending through the cover claim 1 , and the at least one conductive substance is provided on an exterior of the cover tip and within the at least one aperture such that it defines part of the conductive path from the exterior of the cover tip to the digit tip.3. The digit of claim 1 , wherein the at least one conductive substance is selected from the group comprising: a conductive adhesive claim 1 , a conductive paint and a conductive coating.4. The digit of claim 1 , wherein the digit tip is at least partially covered with a first conductive substance claim 1 , and an adjacent portion of the at least one digit member is at least partially covered with a second conductive substance claim 1 , the first and second conductive substances defining the conductive path.5. The digit of claim 4 , wherein the first conductive ...

SYSTEM FOR INCREASING THE NUMBER OF FOCAL POINTS IN ARTIFICIAL EYE LENSES

A system for increasing the number of focal points in artificial eye lenses has a light source that produces a pulsed light via a beam controller that shapes the light beam according to the type of the application and properties of the zone plates that will be produced. A pulse controller conditions the light pulses according to the type of predetermined application and the zone plates that will be produced. A beam director directs the light to predetermined parts of the surface of the artificial eye lens where the zone plates will be produced. A focusing unit focuses the light beam by reducing its diameter. A scanning unit produces zone plates on the artificial eye lens by scanning the light beam on the predetermined parts of the surface of the artificial eye lens where the zone plates will be produced. 112. A system of increasing the number of focal points in artificial eye lenses () , which enables to increase the number of focal points of an artificial eye lens (A) by producing zone plates () on the artificial eye lens (A) , basically comprising{'b': '3', 'at least one light source () which produces a pulsed light, and'}{'b': 4', '3', '2, 'at least one beam controller () which can shape the light beam coming from the light source () according to the type of the application and properties of the zone plates () that will be produced,'}{'b': 5', '2, 'at least one pulse controller () which conditions the light pulses produced by the light source according to the type of predetermined application and the zone plates () that will be produced,'}{'b': 6', '2, 'at least one beam director () which directs the light to the predetermined parts of the surface of the artificial eye lens (A) where the zone plates () will be produced,'}{'b': '7', 'at least one focusing unit () which focuses the light beam by reducing its diameter,'}{'b': 8', '2', '2, 'at least one scanning unit () which produces zone plates () on the artificial eye lens (A) by scanning the light beam on the ...

Systems and Methods for Ligament Graft Preparation

Systems and methods for preparing a ligament graft for a ligament reconstruction procedure are provided. In general, the described techniques utilize a graft preparation system having a holder and a delivery suture assembly removably coupled thereto. The delivery suture assembly can include a spine coupled with an anchor suture configured to form a self-tightening knot used to position the assembly around a graft and a plurality of suture windings configured to be affixed to the graft when the assembly is deployed. The assembly is delivered to the graft using the holder and the sutures can be affixed to the graft without penetrating therethrough. The spine helps to evenly distribute the load among the windings compressing the graft which are thus are capable of withstanding increased loads. Thus, an improved, simplified, and time- and labor-saving approach to preparing ligament grafts is provided.

IMPLANTABLE PROSTHESIS WITH RADIOPAQUE PARTICLES AND METHOD OF MAKING SAME

An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure. 127-. (canceled)28. A method of making an implantable prosthesis , the method comprising:placing radiopaque particles within a lumen of a strut having a plurality of side holes extending from the lumen to an exterior surface of the strut, the radiopaque particles having sizes that prevent the radiopaque particles from passing through the side holes.29. The method of claim 28 , wherein the placing of the radiopaque particles within the lumen includes introducing the radiopaque particles through an end hole of the strut.30. The method of claim 29 , further comprising crimping claim 29 , sealing or plugging the end hole after the introducing of the radiopaque particles through the end hole.31. The method of claim 29 , further comprising forming the side holes through the strut before the introducing of the radiopaque particles through the end hole.32. The method of claim 29 , further comprising forming the side holes through the strut after the introducing of the radiopaque particles through the end hole.33. The method of claim 32 , wherein forming the side holes is performed by any of drilling the strut claim 32 , chemical etching the strut claim 32 , and milling a metal wall of the strut.34. The method of claim 29 , wherein the end hole has a central axis coaxial with a central axis of the lumen.35. The method of claim 28 , wherein further comprising ...

APPARATUS, SYSTEMS AND METHODS FOR MEDICAL DEVICE EXPANSION

A method for manufacturing a medical device. The method can include forming a medical device from a tube having a first diameter; uniformly expanding the medical device from the first diameter to a second diameter at which the medical device can be left within a body vessel, the medical device being expanded from the first diameter to the second diameter while being continuously positioned on an expander; and heat setting the expanded medical device at the second diameter while the medical device is positioned on the expander. 1. A method of manufacturing a medical device , the method comprising:forming a medical device from a tube having a first diameter;uniformly expanding the medical device from the first diameter to a second diameter at which the medical device can be left within a body vessel, the medical device being expanded from the first diameter to the second diameter while being continuously positioned on an expander; andheat setting the expanded medical device at the second diameter while the medical device is positioned on the expander.2. The method of claim 1 , wherein heat setting the expanded medical device comprises maintaining the expanded medical device at the second diameter on the expander for a predetermined period of time while the expander is maintained at a predetermined heat-setting temperature.3. The method of claim 2 , wherein the expander is positioned within a thermal chamber that maintains the expander at the predetermined heat-setting temperature during the steps of uniformly expanding the medical device and heat setting the expanded medical device.4. The method of claim 1 , wherein the medical device is comprised of a shape-memory material.5. The method of claim 1 , wherein the medical device is physically separated from the expander when the medical device is positioned on the expander.6. The method of claim 1 , further comprising:preheating the medical device within a thermal chamber before uniformly expanding the medical device; ...

PROSTHETIC HEART VALVE AND ENDOPROSTHESIS COMPRISING A PROSTHETIC HEART VALVE AND A STENT

The invention relates to a prosthetic heart valve () for an endoprosthesis () used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve () comprises of a plurality of leaflets (), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets () being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve () comprises a leaflet support portion (), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve () to a stent (), and a bendable transition area () which forms a junction between the leaflets () and the leaflet support portion (), the transition area () progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (). The invention further relates to an endoprosthesis () comprising a prosthetic heart valve () and a stent () 150-. (canceled)51. A prosthetic heart valve assembly comprising: a distal portion including a leaflet between a first sleeve and a second sleeve; and', 'a proximal portion having a width less than a width of the distal portion; and, 'at least two pieces of tissue comprisingat least two reinforcement elements;wherein the first sleeve of each piece is coupled to the second sleeve of an adjacent piece to form a commissure of the prosthetic heart valve assembly, and an outer surface of each commissure is covered by one of the reinforcement elements.52. The prosthetic heart valve assembly of claim 51 , wherein each piece of tissue is a monolithic piece of natural tissue or synthetic tissue.53. The prosthetic heart valve assembly of claim 51 , wherein each reinforcement element of the at least two reinforcement ...

Biodegradable endoprostheses and methods of their fabrication

A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex.

PERSONALIZED PROSTHESIS AND METHODS OF USE

A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed. 1. A personalized prosthesis , said prosthesis comprising:A radially expandable prosthesis, wherein the prosthesis is personalized prior to implantation thereof such that the prosthesis substantially matches a shape and a volume of a treatment site.2. A method of treating a treatment site , said method comprising:providing a personalized prosthesis;delivering the prosthesis to the treatment site; andradially expanding the prosthesis into engagement with the treatment site such that the prosthesis substantially matches a shape and a volume of the treatment site. The present application is a continuation of U.S. patent application Ser. No. 15/628,431 (Attorney Docket No. 44600-703.302) now U.S. Pat. No. filed Jun. 20, 2017 which is a continuation of U.S. patent application Ser. No. 14/850,586 (Attorney Docket No. 44600-703.401) now U.S. Pat. No. 9,744,060 filed Sep. 10, 2015 which is a divisional application of U.S. patent application Ser. No. 13/663,160 (Attorney Docket No. 44600-703.201, formerly 45045-703.201) filed Oct. 29, 2012 now abandoned, which is a non-provisional of and claims the benefit of U.S. Provisional Patent Application No. 61/554,099 (Attorney Docket No. 44600-703.101, formerly 45045-703.101) filed Nov. 1, 2011; the entire ...

Stent

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

Methods of Manufacturing a Drug-Eluting Stent

Methods for manufacturing an endovascular stent having channel(s) formed therein for containing a therapeutic material. A molding and sintering process forms a thin-walled tubular component having a tubular core structure encapsulated therein. Portions of the thin-walled tubular component are removed to form at least a portion of the endovascular stent in a pattern corresponding to that of the tubular core structure such that the tubular core structure or corresponding channel(s) left thereby are captured within a wall of the formed stent. The tubular core structure is removed to leave a corresponding channel(s) in its stead. A plurality of holes is formed in the stent wall for filling the stent channel(s) with the therapeutic material and for eluting the therapeutic material therefrom. 1. A method of forming an endovascular stent for delivering a therapeutic material within a vessel comprising the steps of:positioning a tubular core structure in a mold, wherein the tubular core structure has a pattern around which at least a portion of the endovascular stent is to be formed;placing metal particles in the mold around the tubular core structure;applying a force to press together the metal particles and create a solid wall metallic tubular component, wherein the tubular core structure is encased within the solid wall of the metallic tubular component;sintering the metallic tubular component to further solidify the component; andremoving portions of the solid wall of the metallic tubular component to form at least a portion of the endovascular stent in the pattern of the tubular core structure.2. The method of claim 1 , wherein during the step of removing portions of the solid wall of the metallic tubular component the tubular core structure is captured within a wall of the endovascular stent.3. The method of claim 2 , wherein the tubular core structure extends within each strut and crown of the endovascular stent and the method further comprises the step of removing ...

Guide for selecting and positioning a prosthesis

The invention relates to a device (1) and method for selecting the size and shape of a prosthesis and/or for determining the location of marks to be made on the external face of the skin of a patient intended to receive such a prosthesis, for example for repairing a hernia, comprising a sheet (2) of transparent material, the said sheet comprising: —a plurality of graphical representations (3a, 3b, 4a, 4b, 5a, 5b, 5c, 5d) concentrically embodying the respective outlines of various shapes and sizes of prosthesis, —a plurality of first holes (6a, 6b, 6c, 6d, 6e, 7a, 7b, 7c, 7d, 7e) arranged along the transverse line passing through the centre of the said sheet, and —a plurality of second holes (8a, 8b, 8c, 8d, 8e, 8f, 8g, 9a, 9b, 9c, 9d, 9e, 9f, 9g) arranged along the longitudinal line passing through the centre (C) of the said sheet.

LASER DIMPLED STENT FOR PREVENTION OF RESTENOSIS

A dimpled stent design has geometrical characteristics, namely dimple width and depth, which generate dimple site specific turbulence and thrust within the blood flow to reduce or eliminate restenosis. The dimpled stent design is produced by laser processing of the stent material to produce different sizes, which may be predicted by a Multiphysics computational model, placements, and spatial layouts of dimples in the stent. 5. The method of claim 1 , wherein the stent material is a titanium alloy claim 1 , cobalt-chrome alloy claim 1 , or stainless steel.6. The method of claim 1 , further comprising the step of choosing a laser to generate a laser beam claim 1 , wherein the laser is a Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAlO) laser.7. The method of claim 1 , further comprising the step of choosing a laser to generate a laser beam claim 1 , wherein the laser operates at a laser power of 500 W to 1800 W.8. The method of claim 1 , further comprising the step of using a Multiphysics computational model to predict and define features of the one or more dimples produced at the targeted surface areas.10. The method of claim 8 , wherein width and depth of the one or more dimples produced at the targeted surface areas are determined based on the Multiphysics computational model.11. The dimpled stent produced by the method of .12. A dimpled stent claim 1 , comprising:circumferential walls enclosing a cylindrical inner space surrounding a central axis, wherein the circumferential walls comprise one or more laser produced dimples protruding outwardly away from the central axis to create one or more dimpled spaces in outer edges of the cylindrical inner space.13. The dimpled stent of claim 12 , wherein the dimpled stent is about 30 mm long and about 3.5 mm in diameter claim 12 , wherein the circumferential walls are about 0.1 mm thick claim 12 , and wherein the dimples have a depth of about 0.12 mm and a width of about 0.6 mm.14. A dimpled stent claim 12 , comprising:a ...

Implanted Device

Disclosed is an implanted device, comprising a device base body and an active drug, wherein the device base body is pure zinc and/or a zinc alloy, the zinc content in the device base body is 0.1-100%, and the active drug comprises anti-allergic drugs. After the implantation of the implanted device into the human body, the surrounding tissues of the implant would not have a clear hypersensitive reaction due to the presence of the anti-allergic drugs, and the implanted device can be used to be implanted into the body for supporting organ chambers, to fill the hollow chambers of the organs and tissues or as orthopaedic implants etc. 1. An implanted device , comprising a device substrate and an active drug , wherein the device substrate is pure zinc and/or a zinc alloy; the device substrate contains 0.1 to 100 percent of zinc; and the active drug comprises an anti-allergic drug.2. The implanted device according to claim 1 , wherein the implanted device further comprises a zinc complexing agent; wherein the zinc complexing agent and the pure zinc or the zinc alloy in the device substrate form a complex in body fluid.3. The implanted device according to claim 2 , wherein the zinc complexing agent contains at least one coordination group; the coordination group is selected from the group consisting of hydroxyl on polycyclic aromatic hydrocarbon claim 2 , sulfydryl claim 2 , amino claim 2 , an aromatic heterocyclic group claim 2 , nitroso claim 2 , carbonyl claim 2 , sulpho claim 2 , a phosphate group and an organic phosphorus group; the hydroxyl on the polycyclic aromatic hydrocarbon is a phenolic hydroxyl; and the aromatic heterocyclic group is selected from the group consisting of furyl claim 2 , pyrryl claim 2 , imidazolyl claim 2 , triazolyl claim 2 , thienyl claim 2 , thiazolyl claim 2 , pyridyl claim 2 , a pyridone group claim 2 , pyranyl claim 2 , a pyrone group claim 2 , pyrimidyl claim 2 , pyridazinyl claim 2 , pyrazinyl claim 2 , quinolyl claim 2 , isoquinolyl ...

PROSTHETIC PENILE IMPLANTS WITH TETHERED REAR TIP EXTENDERS AND RELATED METHODS

Rear tip extenders include a tether attached to a collar that can be mounted onto a respective cylinder forward of a fluid line (that communicates with a scrotal pump) to prevent full separation or detachment from the cylinder during a revision procedure. 1. A rear tip extender assembly for a penile prosthesis implant , comprising:a rear tip extender and/or rear tip cap sized and configured to attach to an elongate cylinder of a penile prosthesis implant;a collar that is sized and configured to reside against an outer surface of the cylinder; andat least one tether that is attached to the rear tip extender and the collar.2. The rear tip extender assembly of claim 1 , wherein the rear tip extender is a rear tip cap.3. The rear tip extender assembly of claim 2 , wherein the rear tip cap comprises silicone rubber.4. The rear tip extender assembly of claim 1 , wherein the collar and rear tip extender comprise an elastomeric material and the tether is moldably attached to at least one of the collar and rear tip extender.5. The rear tip extender of claim 4 , wherein the tether is moldably attached to both the collar and rear tip extender.6. The rear tip extender assembly of claim 1 , wherein the collar is sized and configured to slidably travel over a forward end of the cylinder and claim 1 , in position claim 1 , resides in front of a fluid line that extends outward from a rear portion of the cylinder.7. The rear tip extender assembly of claim 1 , wherein the collar comprises at least one substantially arcuate longitudinally extending recess.8. The rear tip extender assembly of claim 7 , wherein the collar comprises a plurality of circumferentially spaced apart substantially arcuate recesses.9. The rear tip extender assembly of claim 1 , in combination with at least one other rear tip extender assembly claim 1 , wherein each rear tip assembly has a different length rear tip extender.10. A penile prosthesis implant claim 1 , comprising:an elongate cylinder having ...

BREAST PROSTHESES, METHODS OF MANUFACTURING BREAST PROSTHESES, AND METHODS OF TREATMENT USING BREAST PROSTHESES

Improved breast prostheses, methods of making breast prostheses, and methods of treatment using such breast prostheses are described. 1. A prosthesis comprising a tissue expander and one or more samples of graft material , wherein the one or more samples of graft material is attached to the tissue expander by an adhesive that degrades over time.2. The prosthesis of claim 1 , wherein the adhesive is a synthetic adhesive.3. The prosthesis of claim 2 , wherein the synthetic adhesive is silicone or PMMA.4. The prosthesis of claim 1 , wherein the adhesive is a biological adhesive.5. The prosthesis of claim 4 , wherein the biological adhesive is a marine adhesive.6. The prosthesis of claim 1 , wherein the graft material is further coated with a biologically derived glue.7. A method of making a prosthesis comprising providing a tissue expander and one or more samples of graft material; andattaching the one or more samples of graft material to the tissue expander by an adhesive that will degrade over time.8. The method of claim 7 , wherein the adhesive is a synthetic adhesive.9. The method of claim 8 , wherein the synthetic adhesive is silicone or PMMA.10. The method of claim 7 , wherein the adhesive is a biological adhesive.11. The method of claim 10 , wherein the biological adhesive is a marine adhesive.12. A prosthesis comprising a tissue expander and one or more samples of graft material claim 10 , wherein the tissue expander comprises resorbable tabs or resorbable barbs claim 10 , and wherein the one or more samples of graft material are attached to the tissue expander by the resorbable tabs or resorbable barbs on the tissue expander.13. The prosthesis of claim 12 , wherein the tissue expander comprises resorbable tabs and the one or more samples of graft material comprise apertures.14. The prosthesis of claim 12 , wherein the tissue expander comprises resorbable barbs and the one or more samples of graft material comprise slits.15. The prosthesis of claim 12 , wherein ...

CUP FOR AN ORTHOPAEDIC IMPLANT, ORTHOPAEDIC IMPLANT COMPRISING SUCH A CUP AND METHOD FOR PRODUCING SUCH A CUP

A cup having an inner cavity, for an articulation organ, and a metallic outer layer and in a portion of a spheroid, the outer layer including networks of meshes with nodes and struts, where the struts are tapered struts each having a tapered shape and being arranged such that the tapered shapes are uniformly oriented. 1. A cup , for orthopedic implant such as a cotyloidal implant , intended to be implanted in a bone , the cup having an inner cavity adapted to accommodate an articulation organ , the cup having an outer layer intended to be secured to the bone , the outer layer having overall the shape of a portion of a spheroid , the outer layer being made of metallic material;wherein the outer layer comprises at least one network of meshes defined by nodes and by struts connecting the nodes together, each node being formed by the intersection of several struts, said struts comprising struts called tapered struts which each have a tapered shape, said tapered struts being arranged such that the tapered shapes are uniformly oriented.2. The cup according to claim 1 , wherein said tapered struts are arranged such that their tapered shapes are oriented along respective directions which are circumferential directions for the portion of the spheroid.3. The cup according to claim 2 , wherein at least one subset of tapered struts has tapered shapes oriented along a direction parallel to the equatorial plane of the portion of the spheroid.4. The cup according to claim 1 , wherein at least two tapered struts converge at each node.5. The cup according to claim 1 , wherein each strut has overall the shape of a cylinder of which the axis connects two consecutive nodes of said at least one network.6. The cup according to claim 1 , wherein each tapered strut has a cross-section that is oblong and symmetrical with respect to its longitudinal axis claim 1 , each tapered strut preferably having an overall pear-shaped cross-section.7. The cup according to claim 1 , wherein the outer ...

Mandrel-Less Electrospinning Processing Method and System, and Uses Therefor

A system and method are provided for manufacturing filamentous polymer matrices, comprising electrospinning a polymer fiber into a gap between two or more spaced-apart electrodes. 1. A mandrel-less electrodeposition system for use in preparing a filament comprising:two static or rotating target electrodes having opposing, spaced-apart tips electrically-connected to an electrical power source, the opposing tips of the electrodes defining a deposition target axis;a nozzle electrically-connected to a second electrical power source and spaced apart from the target electrodes and the deposition target axis; anda reservoir configured to deliver a polymer composition through the nozzle and to the deposition target axis.2. The system of claim 1 , wherein the nozzle has a first electrical charge claim 1 , and the target electrodes have a second electrical charge different from the first electrical charge that produces an electric field that causes fibers of a polymer composition deposited through the nozzle into the target deposition axis to align along the target deposition axis between the electrodes.3. The system of claim 1 , wherein the nozzle has a first electrical charge claim 1 , and the target electrodes have a second electrical charge of opposite polarity from the first electrical charge.4. The system of claim 1 , further comprising a needle electrode claim 1 , for example an electrode including an elongated tip portion claim 1 , for example having a diameter of 1 mm or less claim 1 , electrically-connected to an electrical power source and configured for insertion into a fiber formed along the target deposition axis.5. The system of claim 1 , wherein the polymer composition is biocompatible and/or bioerodible.6. The system of claim 1 , wherein the polymer composition comprises one or more of: glycolide claim 1 , lactide claim 1 , caprolactone claim 1 , dioxanone claim 1 , and/or trimethylene carbonate monomers.7. The system of claim 1 , wherein the polymer ...

CUSTOMIZED OPTICAL LENS BASED ON PATIENT-SPECIFIC MEASUREMENT DATA

Methods for a patient surgically receiving a customized IOL for a particular eye according to patient-specific measurement data are provided. The methods may include preoperative evaluation of a particular eye of a particular patient and accumulation of patient-specific measurement data by a physician and/or a hospital. The physician, designee, and/or hospital may transmit the measurement data for the patient to the customized IOL manufacturer. The IOL manufacturer may manufacture and customize the IOL. The manufacturer may deliver the customized IOL back to the surgeon, designee, and/or hospital, after which the surgeon may perform the surgery. 1. A customized IOL for a specific eye of a specific patient comprising:a clear optic comprising an astigmatic axis, andan optic border surrounding a clear lens including two positioning holes located on opposite sides of the clear optic and desirably oriented with respect to the cylinder axis of the astigmatic correction.2. The customized IOL of claim 1 , where in the holes in the optic border surrounding the clear lens are distinguishly shaped.3. The customized IOL of claim 1 , wherein the clear optic comprises a correction of at least one high-order aberration based on preoperative measurements for the specific eye of the specific patient.4. The customized IOL of further comprising haptics positioned based on the preoperative measurements for the specific eye of the specific patient.5. The customized IOL of claim 4 , wherein the haptics are positioned to minimize negative dysphotopsia when the astigmatic axis of the IOL is properly oriented in the specific eye of the specific patient.6. The customized IOL of further comprising a power with a precision of 0.05 D or 0.1 D increments in sphere and cylinder and increments of 0.05-micron root mean square error in total high-order aberrations or in any specific aberration.7. The customized IOL of further comprising a spherical aberration offset of 0.1 to 0.3-micron root mean ...

BIORESORBABLE, IMPLANTABLE DEVICE HAVING CONTROLLED DRUG DELIVERY

A bioresorbable, implantable device having controlled drug delivery is disclosed herein. The bioresorbable, implantable device is configured as a film, a roll, a tube, and a stent. The bioresorbable, implantable device is configured to release an active ingredient (the “drug”) from the bioresorbable, implantable device when the bioresorbable, implantable device is implanted within a body. The bioresorbable, implantable device is configured to control the onset of the release of the drug, the sequence of drug delivery, and the duration of drug delivery by embedding the drug within at least one therapeutic layer positioned within bioresorbable, implantable device. 1. A bioresorbable implantable device comprising:an implantable film comprising a film width, a film length, two film major surfaces, four film minor surfaces and a film thickness comprising at least one bioresorbable material,a removable release media, anda temporary bond, excluding a separate adhesive, disposed between the release media and at least one film major surface of said film.2. The film of including omission of said release media and said temporary bond.3. The film of including a configuration suitable for implantation within a living body.4. The film of including a roll configuration comprising a beginning of the roll claim 2 , an end of the roll claim 2 , a roll inner diameter claim 2 , a roll outer diameter claim 2 , a roll length claim 2 , a roll passageway claim 2 , a roll central axis and a roll thickness comprising multiple said film thicknesses in spiral cross section perpendicular to the roll central axis claim 2 , wherein said beginning of the roll is disposed inside the roll passageway and the end of the roll disposed outside the roll.5. The roll of including a bond claim 4 , comprising at least one part said bioresorbable material claim 4 , disposed between the adjacent film thicknesses within the roll thickness claim 4 , the roll comprising the bonded film thicknesses transformable ...

STENT AND METHOD OF MAKING SAME

A stent for vascular interventions having a hybrid open cell geometry. Variants of the stent include bare metal stents and drug-eluting stents. Embodiments of the stent include end projections for radiopaque markers or a discontinuous partial radiopaque coating on low-stress or low-strain regions of the peripheral stent. The stents of the invention are characterized by having thin walls, nested rows of struts, high expansion ratio, high and uniform radial force over entire diametric size and length of device, crush resistance up to and including about 90% of its fully expanded diameter, high fatigue resistance and high corrosion resistance. 1. A method of making a stent , comprising the steps of:a. Providing a stent hypotube;b. Patterning the stent hypotube with a stent pattern;c. Forming a plurality of volume-enhancing features in or on an outer abluminal surface of the stent pattern;d. Releasing the stent pattern from the stent hypotube; ande. Coating the outer abluminal surface of the stent pattern with a drug-release coating and at least substantially filling the plurality of volume-enhancing features.2. The method of claim 1 , wherein the step of providing a stent hypotube further comprises the step of making the stent hypotube from a binary claim 1 , ternary or quaternary shape memory or superelastic material.3. The method of claim 2 , wherein the step of making a stent hypotube further comprises the step of alloying a radiopaque material with shape memory or superelastic material.4. The method of claim 1 , further comprising the step of coating at least a portion of the released stent pattern with a radiopaque material prior to conducting step e.5. The method of claim 1 , further comprising the step of coating low-stress regions of the released stent with a radiopaque material.6. The method of claim 1 , wherein the step of patterning the stent hypotube further comprises the steps of:a. Forming a plurality of generally sinusoidal circumferential ring members ...

RADIOPAQUE MARKER ASSEMBLY

A radiopaque marker having a frame and a radiopaque cuff joined to the frame. The frame includes first and second end frame members and lateral frame members. The radiopaque cuff is joined to the frame such that the radiopaque cuff is substantially co-planar with the first and second end frame members. The radiopaque marker may be joined to a stent, such as for vascular interventions. Variants of the stent include bare metal stents and drug-eluting stents. Embodiments of the stent include end projections for radiopaque markers or a discontinuous partial radiopaque coating on low-stress or low-strain regions of the peripheral stent. The stents are characterized by having thin walls, nested rows of struts, high expansion ratio, high and uniform radial force over entire diametric size and length of device, crush resistance up to and including about 90% of its fully expanded diameter, high fatigue resistance and high corrosion resistance. 1. A radiopaque marker comprising , a frame member having a recessed portion and a radiopaque cuff coupled to the frame member and the recessed portion.2. The radiopaque marker of claim 1 , wherein the radiopaque cuff has a surface that is substantially co-planar with the frame member.3. The radiopaque marker of claim 1 , wherein the frame member further comprises a substantially quadrilateral frame having a central open region.4. The radiopaque marker of claim 3 , wherein the recessed portion further comprises at least one surface of the substantially quadrilateral frame.5. The radiopaque marker of claim 3 , wherein the radiopaque cuff has a portion thereof recessed within the central open region.6. The radiopaque marker of wherein the substantially quadrilateral frame further comprises a first end frame member and a second end frame member claim 3 , each of the first end frame member and the second end frame member having a longitudinal axis substantially orthogonal to a longitudinal axis of the substantially quadrilateral frame.7. ...

HIGHLY ELASTIC STENT AND PRODUCTION METHOD FOR HIGHLY ELASTIC STENT

A highly elastic stent is made of an alloy that exhibits superelasticity at body temperature. At least a part of the highly elastic stent has such a property that load increases with displacement without exhibiting a distinct yield on a load-displacement curve obtained by a compression test and a bending test. 12-. (canceled)3. A method for producing a highly elastic stent the method comprising:inserting a rod-shaped core metal into a hollow portion of a tube-shaped stent base;maintaining, as needed, linearity of the stent base with the core metal inserted therein, and thereafter, cutting slot forming portions with a laser light while suppressing a heat effect by the laser light on a periphery of the slot forming portions so as to form slots and thus to make a stent; andremoving the core metal from the stent, whereinat least a part of the highly elastic stent has such a property that load increases with displacement without exhibiting a distinct yield on a load-displacement curve obtained by a compression test and a bending test.4. The method for producing the highly elastic stent according to claim 3 , the method further comprising expanding the stent from which the core metal has been removed to a predetermined diameter while performing heat treatment on the stent at 350° C. or below.5. The method for producing the highly elastic stent according to claim 3 , wherein the slots are formed by cutting the slot forming portions with a laser that uses a water jet claim 3 , which is formed so as to reach the stent base claim 3 , as a waveguide of the laser light.6. The method for producing the highly elastic stent according to claim 4 , wherein the slots are formed by cutting the slot forming portions with a laser that uses a water jet claim 4 , which is formed so as to reach the stent base claim 4 , as a waveguide of the laser light.7. A method for producing a highly elastic stent claim 4 , the method comprising:inserting a rod-shaped core metal into a hollow portion of ...