Spondylolisthesis correction apparatus and method

An apparatus and method are provided that allow for the realignment and stabilization of adjacent vertebrae. An implant of this invention both repositions adjacent vertebrae and remains in situ to maintain the new position. The implant has two halves which are interlocked such that they can slide horizontally with respect to each other. Movement of the implant halves and their respective positions are controlled by set screw within the implant. The implant includes radial anchors which fit into alignment slots made in the misaligned vertebra by the disclosed method. The set screws are used to advance the halves of the implant which in turn move the misaligned vertebrae back into correct positions. The correct position of the vertebrae is locked in place through a nut and a plate.

Bone graft materials and methods

Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.

IMPLANTABLE MESH

An implantable mesh including demineralized bone fibers mechanically entangled into a biodegradable or permanent implantable mesh is provided. A method of preparing the implantable mesh is also provided. The method of preparing the implantable mesh includes mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh. The mechanical entanglement of the bone fibers into the implantable mesh is achieved by applying needle punching with barbed needles, spun lacing, entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves. A method of implanting an implantable mesh at a target bone tissue site is also provided. 111-. (canceled)12. A method of preparing an implantable mesh , the method comprising mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh.13. A method of claim 12 , wherein the mechanical entangling comprises applying needle punching with barbed needles claim 12 , spun lacing claim 12 , entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves.14. A method of claim 13 , wherein the mechanical entangling further comprises applying to the implantable mesh moisture claim 13 , heat and/or pressure provided by pressure rollers.15. A method of claim 12 , wherein (i) the mesh is porous having pores from about 100 to about 200 μm; (ii) the mesh does not contain a carrier; or (iii) the mesh is woven claim 12 , non-woven claim 12 , knitted claim 12 , wrapped claim 12 , plied claim 12 , braided or a mixture thereof.16. A method of claim 12 , wherein the demineralized bone fibers have (i) an aspect ratio of from about 50:1 to about 1000:1; (ii) a diameter from about 100 μm to about 2 mm; or (ii) a length from about 0.5 cm to about 10 cm.17. A method of implanting an implantable mesh at a target bone tissue site claim 12 , the method comprising contacting the bone tissue site with the implantable mesh claim 12 , the ...

APPARATUS AND METHOD FOR PRODUCING AUGMENTIVE PRODUCTS

An apparatus for shaping a Platelet Rich Fibrin component of patient whole blood includes a main body. The main body includes a substantially planar surface. The main body also has a reservoir positioned therein. The substantially planar surface includes a plurality of channels fluidly connecting the substantially planar surface and the reservoir. The apparatus also includes a lid which is positioned over the substantially planar surface. The lid is used to compress a Platelet Rich Fibrin component. Liquids that are expressed from the Platelet Rich Fibrin component flow to the reservoir. The apparatus also includes openings for forming plugs of Platelet Rich Fibrin material. 1. An apparatus for shaping a Platelet Rich Fibrin component of patient whole blood comprising:a main body further comprising a substantially planar surface;a reservoir positioned in the main body; anda plurality of channels fluidly connecting the substantially planar surface and the reservoir.2. The apparatus for shaping a Platelet Rich Fibrin component of patient whole blood of wherein the substantially planar surface is inclined toward the reservoir.3. The apparatus for shaping a Platelet Rich Fibrin component of patient whole blood of further comprising a table stand claim 1 , the main body having a receiver for the table stand positioned so that when the table stand engages the receiver claim 1 , the main body inclines toward the reservoir.4. The apparatus for shaping a Platelet Rich Fibrin component of patient whole blood of wherein the plurality of channels fluidly connecting the substantially planar surface and the reservoir are inclined with respect to the substantially planar surface claim 1 , the incline toward the reservoir.5. The apparatus for shaping a Platelet Rich Fibrin component of patient whole blood of further comprising a lid which covers at least a portion of the substantially planar surface claim 1 , the lid for forming a membrane of Platelet Rich Fibrin material.6. The ...

BONE IMPLANT FOR ENCLOSING BONE MATERIAL

A bone implant for enclosing bone material is provided. The bone implant comprises a mesh having an inner surface and an outer surface opposing the inner surface. The inner surface is configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh. The plurality of projections extend from at least the portion of the inner surface of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both sections of the inner and outer surfaces of the mesh in a closed configuration so as to enclose the bone material. A tray, a kit and a method of making the bone implant are also provided. 1. A bone implant for enclosing bone material , the bone implant comprising:a mesh having an inner surface and an outer surface opposing the inner surface, the inner surface configured to receive a bone material when the inner surface of the mesh is in an open configuration; anda plurality of projections disposed on or in at least a portion of the inner surface of the mesh, the plurality of projections extending from at least the portion of the inner surface of the mesh and configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both sections of the inner and outer surfaces of the mesh in a closed configuration so as to enclose the bone material.2. The bone implant of claim 1 , wherein (i) the mesh is foldable in the closed configuration to enclose the bone material; (ii) the inner surface of the mesh comprises a fold line extending from a distal end to a proximal end of the inner surface claim 1 , the fold line forming a compartment to receive the bone material; (iii) the mesh is configured to roll the section of the inner surface over the bone material to enclose the bone material; (iv) the plurality of projections are ...

SYSTEM AND METHOD TO FUSE BONE

An implant is provided that is operable to be disposed between and fuse two sections of a bone. The implant includes an inner layer and an outer layer. The outer layer at least partially surrounds the inner layer and is operable to abut against the two sections of the bone. The outer layer is porous and/or fibrous and is operable to receive at least one cellular growth factor. 1. An implant operable to be disposed between and fuse two sections of a bone , the implant comprising:an inner layer; andan outer layer at least partially surrounding the inner layer and operable to abut against the two sections of the bone, the outer layer being porous and/or fibrous and operable to receive at least one cellular growth factor.2. The implant of claim 1 , wherein the outer layer includes a first portion and a second portion claim 1 , the inner layer is sandwiched between the first and second portions of the outer layer.3. The implant of claim 1 , wherein the outer layer is wrapped around a circumference of the inner layer.4. The implant of claim 1 , wherein the inner layer and/or the outer layer includes at least a portion of at least one of the following: cortical bone fibers claim 1 , cancellous bone fibers claim 1 , collagen sponge claim 1 , cortical bone graft claim 1 , synthetic bone claim 1 , and/or tissue graft.5. The implant of claim 1 , wherein the at least one cellular growth factor includes bone morphogenetic proteins claim 1 , mesenchymal stem cells claim 1 , blood claim 1 , osteoclasts claim 1 , osteoblasts claim 1 , antibiotics claim 1 , analgesics claim 1 , and/or medications.6. The implant of claim 1 , wherein the inner layer is fenestrated to promote bony ingrowth.7. The implant of claim 1 , wherein the implant has a thickness between about 2 millimeters and about 100 millimeters.8. The implant of claim 1 , wherein the implant has a length between about 25 millimeters and about 250 millimeters.9. The implant of claim 1 , wherein the implant has a depth between ...

IMPLANTABLE MESH

An implantable mesh including demineralized bone fibers mechanically entangled into a biodegradable or permanent implantable mesh is provided. A method of preparing the implantable mesh is also provided. The method of preparing the implantable mesh includes mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh. The mechanical entanglement of the bone fibers into the implantable mesh is achieved by applying needle punching with barbed needles, spun lacing, entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves. A method of implanting an implantable mesh at a target bone tissue site is also provided. 1. An implantable mesh comprising demineralized bone fibers mechanically entangled into the implantable mesh.2. An implantable mesh of claim 1 , wherein the implantable mesh comprises (i) a demineralized bone fiber mechanically entangled with a biodegradable mesh fiber; (ii) a plurality of biodegradable mesh fibers mechanically entangled with each other that are then mechanically entangled with one or more demineralized bone fibers; or (iii) biodegradable fibers mechanically entangled with the demineralized bone fibers to form a plurality of layers in the implantable mesh.3. An implantable mesh of claim 1 , wherein the mesh is formed into a sheet claim 1 , plate claim 1 , disk claim 1 , tunnel claim 1 , cone or tube.4. An implantable mesh of claim 1 , wherein (i) the mesh is porous having pores from about 100 μm to about 200 μm; (ii) the mesh does not contain a carrier; or (iii) the mesh is woven claim 1 , non-woven claim 1 , knitted claim 1 , wrapped claim 1 , plied claim 1 , braided or a mixture thereof.5. An implantable mesh of claim 1 , wherein the mesh comprises (i) natural materials claim 1 , synthetic polymeric resorbable materials claim 1 , synthetic polymeric non-resorbable materials or mixtures thereof; or (ii) carbon fiber claim 1 , metal fiber claim 1 , polyetheretherketones claim ...

Intrabody Osteotomy Implant and Methods of Use

Methods for surgically adjusting a curvature of a spine are disclosed. The methods provide for controlling the alignment of bony structures, such as vertebral bodies or portions thereof, as they are moved relative to one another during a surgical procedure. An intrabody implant disclosed and methods of use are also disclosed. The implant has an inclined surface, forming a wedge or other shape having, for example, an acute angle adapted to be placed between at least two separated portions of a single bony structure (such as a vertebral body). In some embodiments, the implant may be used to support portions of a vertebral body that have been separated surgically as part of a pedicle subtraction osteotomy and to orient the portions at a more predictable lordotic angle. 1. A method for surgically adjusting a curvature of a spine comprising vertebrae , the method comprising:removing a portion of a single vertebral body of the spine to form two at least partially separated portions of the single vertebral body;inserting a first pedicle screw into a second vertebral body superior to the single vertebral body and a second pedicle screw into a third vertebral body inferior to the single vertebral body;connecting the first pedicle screw and the second pedicle screw with a rod; andbringing into closer proximity the two at least partially separated portions of the single vertebral body such that the first and second pedicle screw advance towards one another along the rod.2. The method as recited in claim 1 , wherein after the step of bringing into closer proximity the at least partially separated portions of the single vertebral body are oriented at a correction angle relative to one another.3. The method as recited in claim 2 , wherein the correction angle provides a lordotic correction to a spinal column at the level of the single vertebral body.4. The method as recited in claim 3 , wherein the correction angle provides a kyphotic correction to a spinal column at the level of ...

TENDON REPAIR IMPLANT AND METHOD OF ARTHROSCOPIC IMPLANTATION

A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time. 1. A method of repairing a tendon , the method comprising:arthroscopically delivering a sheet-like implant to a surface of the tendon with the sheet-like implant in a first compact configuration, the sheet-like implant having a longitudinal dimension, a lateral dimension, and a thickness dimension, the sheet-like implant having an initial tensile modulus in the longitudinal dimension of 1 MPa to 50 MPa in a range of 1% to 3% strain in the longitudinal dimension, where 0% strain is defined with a 1 N preload applied to the sheet-like implant, the sheet-like implant formed of reconstituted collagen material having a porosity of 30% to 90% for tissue in-growth, wherein the reconstituted collagen material has a longitudinal alignment of collagen fibers which form longitudinal pathways extending along the longitudinal dimension of the sheet-like implant;deploying the sheet-like implant by transforming the sheet-like implant to a second configuration wherein a surface of the sheet-like implant faces the surface of the tendon;contacting and conforming the surface of the sheet-like implant to the surface of the tendon with the longitudinal dimension aligned with a load bearing direction of the tendon; andaffixing the sheet-like implant to the surface of the tendon ...

Cartilage Mosaic Compositions and Methods

Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

METHOD FOR FUSION OF FRACTURED OR VOIDED STERNUM POST STERNOTOMY

Disclosed herein are improved surgical techniques for repairing bone defects in a sternum during a sternotomy procedure and implants adapted for such techniques. In an exemplary embodiment, provided is a fusion strip made of an osteoconductive material and of a dimension that is especially adapted for improved repair of sternal bone defects. 1. A method for closing a sternum separated into at least a first sternum section having a first surgical cut site and a second sternum section having a second surgical cut site in a patient in need thereof , the method comprising:i) obtaining a first fusion strip and a second fusion strip, where said first and second fusion strips are comprised of an osteoconductive material and comprise a dimension of 3-12×45-60×3-8 mm (width×length×thickness);ii) positioning a first fusion strip into a void or fracture in either said first and second sternum portions at said first and second surgical cut sites, or both;iii) positioning a second fusion strip into said void adjacent to an end of said first fusion strip; andiv) urging together said first and second sternum portions such that said first and second surgical cut sites are brought together with said first and second fusion strips being in contact with either or both of said first or second surgical cut sites.2. The method according to claim 1 , wherein step i) or step ii) claim 1 , or both claim 1 , comprise securing said first and/or second fusion strips to one of said first or second sternum portions.3. The method of claim 2 , wherein securing comprises utilizing a suture and/or an adhesive claim 2 , or mesh.4. The method of claim 1 , further comprising positioning a third fusion strip to said first or second sternum portion claim 1 , wherein said third fusion strip comprises a dimension of 9-12×45-60×3-8 mm (width×length×thickness).5. The method of claim 4 , wherein said third fusion strip is positioning in a void at the manubrium.6. The method of claim 4 , wherein said third ...

Engineered Sterile Cartilage Implant Plug(s) With Sterile, Specific Instrument Kit(s)

An apparatus and a method are provided for performing cartilage graft implant surgeries. The apparatus comprises a graft plug kit comprising one or more grafts configured to treat osteochondral defects in various bone joint locations in a patient's body. Each of the grafts comprises a cartilage layer coupled with a bone portion. The cartilage layer comprises a thickness selected to closely match the thickness of existing cartilage at an implant location. The bone portion comprises surface features configured to encourage the patient's bone tissue to grow into the bone portion, thereby accelerating incorporation of the graft into the patient's bone. An instrument kit comprises a multiplicity of instruments configured for implantation of the grafts into the patient's body, including at least a graft inserter, a guidewire, a reamer, and a size gauge. 1. A sterile graft plug kit for treating osteochondral defects in bone joint locations in a patient's body , comprising:one or more grafts configured to treat the osteochondral defects, the one or more grafts each comprising a cartilage layer coupled with a bone portion that are comprised of materials suitable for implantation in the joint locations; anda sterile instrument kit comprising a multiplicity of instruments configured for implanting the one or more grafts into the patient's body.2. The sterile graft plug kit of claim 1 , wherein the multiplicity of instruments is comprised of at least a graft inserter claim 1 , a guidewire claim 1 , a reamer claim 1 , and a size gauge.3. The sterile graft plug kit of claim 2 , wherein the graft inserter comprises an elongate member having a distal graft retainer and a proximal applicator claim 2 , the distal graft retainer being configured to receive and hold a graft claim 2 , the proximal applicator being configured to enable pushing the graft out of the distal graft retainer and into an osteochondral bore in the patient's body.4. The sterile graft plug kit of claim 2 , wherein ...

Intrabody Osteotomy Implant and Methods of Use

Methods for surgically adjusting a curvature of a spine are disclosed. The methods provide for controlling the alignment of bony structures, such as vertebral bodies or portions thereof, as they are moved relative to one another during a surgical procedure. An intrabody implant disclosed and methods of use are also disclosed. The implant has an inclined surface, forming a wedge or other shape having, for example, an acute angle adapted to be placed between at least two separated portions of a single bony structure (such as a vertebral body). In some embodiments, the implant may be used to support portions of a vertebral body that have been separated surgically as part of a pedicle subtraction osteotomy and to orient the portions at a more predictable lordotic angle. 1. (canceled)2. A system comprising: a first surface configured for engaging a first vertebra,', 'a second surface opposite the first surface configured for engaging a second vertebra, and', 'a wall disposed from the first surface to the second surface, the wall comprising extending along a longitudinal axis between an anterior portion and a posterior portion, the posterior portion having a maximum height that is less than a maximum height of the anterior portion, the posterior portion of the wall comprising an outer concave surface, the anterior portion of the wall comprising an outer convex surface, the posterior portion of the wall defining a convex profile from the first surface to the second surface, the posterior portion comprising a threaded bore that extends parallel to the longitudinal axis through opposite inner and outer surfaces of the wall such that the bore is positioned between the first and second surfaces,, 'an intrabody implant adapted to be placed between at least two separated portions of a single bony structure, the intrabody implant comprisinga first and a second pedicle screw each comprising at least one head, and a third and a fourth pedicle screw each comprising at least one head ...

METHODS OF IMPLANTING A DRY BIOPROSTHETIC VALVED CONDUIT

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A method of preparing and delivering a valved conduit , comprising:removing a pre-assembled valved conduit from a dry package in which the valved conduit is stored without a preserving solution, the valved conduit including a bioprosthetic heart valve coupled to a conduit, the heart valve having leaflets of bioprosthetic tissue and the conduit being sealed with a bioresorbable medium; anddelivering and securing the valved conduit to an implantation site.2. The method of claim 1 , wherein the conduit is secured to the bioprosthetic valve using sutures.3. The method of claim 2 , wherein the heart valve has a suture-permeable sewing ring surrounding an inflow end thereof claim 2 , wherein an inlet end of the conduit is secured to the sewing ring with sutures.4. The method of claim 3 , wherein the heart valve has commissure posts between which the leaflets are supported and a sewing ring claim 3 , and the heart valve couples to the conduit with the commissure posts inside the conduit and the sewing ring outside the conduit.5. The method of claim 1 , ...

METHODS OF PREPARING AND DELIVERING A DRY BIOPROSTHETIC VALVED CONDUIT

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A method of preparing and delivering a valved conduit , comprising:procuring a pre-assembled valved conduit including a prosthetic heart valve having bioprosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve, the valve being coupled to a conduit sealed with a bioresorbable medium so as to provide the valved conduit and stored in a dry package including at least one sterile container in which the valved conduit is stored without a preserving solution;opening the dry package and removing the valved conduit; anddelivering the valved conduit to an implantation site.2. The method of claim 1 , wherein the conduit is secured to the bioprosthetic valve using sutures.3. The method of claim 1 , wherein the bioprosthetic valve couples within the conduit such that the conduit extends on both ends of the valve to provide both inflow and outflow extensions.4. The method of claim 1 , wherein the bioprosthetic valve is a heart valve and includes bovine pericardial ...

SYSTEM AND METHOD TO FUSE BONE

An implant is provided that is operable to be disposed between and fuse two sections of a bone. The implant includes a material that is operable to abut against the two sections of the bone. The material is porous and/or fibrous and is operable to receive at least one cellular growth factor. 1. An implant operable to be disposed between and fuse two sections of a bone , the implant comprising:a material operable to abut against the two sections of the bone, the material being porous and/or fibrous and operable to receive at least one cellular growth factor.2. The implant of claim 1 , further comprising an inner layer and an outer layer claim 1 , wherein the inner layer and the outer layer are both made of the material claim 1 , wherein the outer layer includes a first portion and a second portion claim 1 , the inner layer is sandwiched between the first and second portions of the outer layer.3. The implant of claim 2 , wherein the outer layer is wrapped around a circumference of the inner layer.4. The implant of claim 1 , wherein the material includes at least a portion of at least one of the following: cortical bone fibers claim 1 , cancellous bone fibers claim 1 , collagen sponge claim 1 , cortical bone graft claim 1 , synthetic bone claim 1 , and/or tissue graft.5. The implant of claim 1 , wherein the at least one cellular growth factor includes bone morphogenetic proteins claim 1 , mesenchymal stern cells claim 1 , blood claim 1 , osteoclasts claim 1 , osteoblasts claim 1 , antibiotics claim 1 , analgesics claim 1 , and/or medications.6. The implant of claim 1 , wherein the material is fenestrated to promote bony ingrowth.7. The implant of claim 1 , wherein the implant has a thickness between about 2 millimeters and about 100 millimeters.8. The implant of claim 1 , wherein the implant has a length between about 25 millimeters and about 250 millimeters.9. The implant of claim 1 , wherein the implant has a depth between about 1 millimeter and about 30 millimeters. ...

PRE-ASSEMBLED PACKAGED BIOPROSTHETIC VALVE CONDUIT

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A pre-assembled , packaged valved conduit , comprising:a bioprosthetic valve including bioprosthetic tissue, the valve having been treated such that the bioprosthetic tissue has less than 70% water content and may be stored dry for extended periods without degradation of functionality of the valve;a conduit sealed with a bioresorbable medium to which the bioprosthetic valve is coupled so as to provide the valved conduit; anddry packaging for the valved conduit including at least one sterile container in which the valved conduit is stored without a preserving solution.2. The valved conduit of claim 1 , wherein the conduit is secured to the bioprosthetic valve using sutures.3. The valved conduit of claim 1 , wherein the bioprosthetic valve is a heart valve and includes bovine pericardial leaflets claim 1 , and the conduit comprises a tubular matrix impregnated with collagen.4. The valved conduit of claim 1 , wherein the tissue has been cross-linked using glutaraldehyde or other aldehyde containing agents claim 1 , treated with a capping agent claim ...

PERCUTANEOUSLY IMPLANTABLE REPLACEMENT HEART VALVE DEVICE AND METHOD OF MAKING SAME

A replacement heart valve device including a stent member that is to be compressible and expandable, and a dry valve directly sutured to the stent member. The dry valve includes two to four leaflets made of a treated pericardium tissue that has been gas sterilized. 1. A replacement heart valve device , comprising:a stent member, the stent member configured to be compressible and expandable; anda dry valve directly sutured to the stent member, wherein the dry valve includes two to four leaflets made of a treated pericardium tissue, and wherein the treated pericardium tissue has been gas sterilized.2. The replacement heart valve device of claim 1 , wherein the stent member is self-expanding.3. The replacement heart valve device of claim 1 , wherein the stent member is balloon expandable.4. The replacement heart valve device of claim 1 , wherein the stent member is made of nitinol.5. The replacement heart valve device of claim 1 , wherein the stent member is made of stainless steel.6. The replacement heart valve device of claim 1 , wherein the stent member includes a tubular structure that flares at both ends in a trumpet-like configuration.7. The replacement heart valve device of claim 1 , wherein the treated pericardium tissue comprises treated mammalian pericardium tissue.8. The replacement heart valve device of claim 7 , wherein the treated pericardium tissue has been treated with glutaraldehyde.9. The replacement heart valve device of claim 8 , wherein a pericardium tissue forming the dry valve has been subjected to light and mechanical compression to decrease the molecular distance of collagen fibers.10. An assembly for percutaneous and transluminal delivery of a medical implant claim 8 , comprising:a delivery and implantation system including a flexible catheter; and a stent member, the stent member configured to be compressible and expandable; and', 'a dry valve directly sutured to the stent member, wherein the dry valve includes two to four leaflets made of ...

CARTILAGE MOSAIC COMPOSITIONS AND METHODS

Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided. 143- (canceled)44. A mosaic cartilage composition comprising:a 1 mm thick cartilage sheet comprising a plurality of interconnected cartilage tiles that are separated by channels formed in the cartilage sheet, each channel having a respective depth that is less than 1 mm, and wherein perforations are formed in the cartilage sheet beneath one or more of the channels; anda cryopreservation medium.45. The mosaic cartilage composition of claim 44 , wherein the cartilage that is beneath the channels has a thickness of less than 0.25 mm.46. The mosaic cartilage composition of claim 44 , wherein the perforations are microperforations.47. The mosaic cartilage composition of claim 44 , wherein the cartilage is articular cartilage.48. The mosaic cartilage composition of claim 44 , wherein the cartilage is non-decellularized cartilage.49. The mosaic cartilage composition of claim 44 , wherein the cartilage is from a human adult cadaveric donor age 15 years or older.50. The mosaic cartilage composition of claim 44 , wherein the cartilage is from a human juvenile cadaveric donor.51. The mosaic cartilage composition of claim 44 , wherein the tiles are square or rectangular in shape and uniform in size.52. The mosaic cartilage composition of claim 51 , wherein the cartilage tiles have an average length and width from about 0.5 mm to about 3 mm.53. The mosaic cartilage composition of claim 44 , wherein the cryopreservation medium comprises dimethyl sulfoxide (DMSO) and serum.54. The mosaic cartilage composition of claim 44 , wherein the cryopreservation medium comprises a cryoprotective agent claim 44 , the cryoprotective agent comprises at least one of glycerol claim 44 , DMSO claim 44 , ...

System and method to fuse bone

Systems and methods include a method to fuse two sections of bone. The method includes various operations such as accessing the chest cavity (e.g., by severing the sternum) and preparing the sternal edges of the two sections of bone. Sternal wires are implanted around the two sections of bone to create a cradle in a space between the two sections of bone. Cancellous bone tissue may be harvested from the patient and used to hydrate an implant before trimming the implant and/or placing the implant in the cradle. The sternal wires are tightened to compress the implant between the two sections of bone; and the ends of the sternal wires are tied together to create a sternal structure comprised of the implant tightly compressed between the two sections of bone. The sternal construct can act as a bone gasket to improve healing and fusing for the two sections of bone.

Tendon repair implant and method of arthroscopic implantation

A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by an arthroscopic means approach that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.

BIOCOMPATIBLE CONTAINMENT MEMBER FOR BONE AUGMENTATION SURGERY MADE OF PROCESSED NATURAL MEMBRANE FROM AN ANIMAL DONOR

A surgically implantable containment member for maintaining a bone augmentation material in a desired location and/or configuration following implantation in a human or other mammalian patient, in which the containment member is made of a natural membrane, such as pericardium, isolated from an animal donor and processed to avoid inflammation or tissue rejection, and a method of bone augmentation using such a containment member. In a particularly preferred embodiment, the containment member has a window which rapidly dissipates upon exposure to bodily fluids after implantation to expose bone augmentation material contained within the containment member to an adjacent bone to be augmented. 1. A surgically implantable containment member for maintaining a bone augmentation material in a desired location and/or configuration following implantation in a mammalian patient , wherein said containment member is comprised of a natural membrane isolated from an animal donor and processed to avoid inflammation or tissue rejection , wherein said containment member comprises an arcuate sheet with parallel leg sections joined at one end by a closed curved section and further comprising a flap which serves as a point of attachment for fixing the containment member in a desired implanted location.2. A containment member according to claim 1 , wherein following the processing said containment member retains the natural membrane structure of the isolated natural membrane.3. A containment member according to claim 1 , wherein said isolated natural membrane is pericardial membrane.4. a containment member according to claim 1 , wherein said containment member has the form of a cylindrical capsule formed of two sections each of which has a closed end and an open end with the open end of one section sized for mating insertion into the open end of the other section to form a closed containment structure.5. A containment member according to claim 4 , wherein at least one section comprises a ...

Implantable biological joint replacement

The present invention concerns the problem of solving issues of common mechanical endoprostheses and limitations of current cartilage replacement methods by manufacturing a complete implantable biological joint replacement. Devices which provide for the shaping, diffusion activation and particularly fulling of the joint replacement which is being produced—i.e. compression with alternating pressure and possibly a gliding motion of the fulling device on the surface of the joint replacement—are used in order to produce a weight bearing biological joint replacement with hyaline cartilage. Substances and processes which activate the formation of hyaline cartilage tissues are also provided. At the present time, the biological joint replacement is preferably suitable for implantation into the shoulder and hip, but can also be used for other joints by applying multidimensional grinding techniques.

Modified surfaces for attachment of biological materials

The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under appropriate conditions. Fibroblasts and endothelial cells exhibit good attachment and growth on most coated substrates, except on nano surfaced structured silicone.

Surgical Technique for alveolar ridge augmentation with maxillary sinus elevation (lateral approach) using a pre-portioned and ready pre-packaged graft composition in gelatin bag and method of producing it

The present embodiment relates generally to methods of performing surgical technique maxillary sinus floor augmentation with a lateral approach using a pre-portioned and ready pre-packaged bone graft composition in gelatin bags and method of producing gelatin bags. In addition the present inventions can be widely used in other medical fields such as dentistry, orthopedic surgery, spine surgery, plastic and reconstruction surgery, sport medicine, trauma surgery, phinoplasty surgery and veterinary. 1. A surgical technique for alveolar ridge augmentation with maxillary sinus elevation (lateral approach) using a pre-portioned and ready pre-packaged bone graft composition in gelatin bag , comprising:a first step of performing a trapezoid incision into soft tissue of gingiva in surgical area to create a trapezoid shaped flap;a second step of retracting back the trapezoid shaped flap of the soft tissue to expose an underlying lateral boney wall of the maxillary sinus;a third step of creating an access to the maxillary sinus, to get access to expose sinus membrane and detaching the sinus membrane from a bone of an inferior surface of a sinus cavitya fourth step applying pre-portioned and ready pre-packaged bone graft composition in gelatin bags into newly created space;a fifth step inserting dental implant through vertical opening;a sixth step suturing the trapezoid shaped flap into the soft tissue;2. The surgical technique of claim 1 , wherein the pre-portioned and ready pre-packaged bone graft composition in the gelatin bag contains bone graft material.3. The surgical technique of wherein-the pre-portioned and ready pre-packaged bone graft composition in the gelatin bag comprises coherent mass bone graft chips harvested from cortical bone.4. The surgical technique of wherein the pre-portioned and ready pre-packaged bone graft composition in the gelatin bag comprises coherent mass bone graft chips harvested from cancellous bone.5. The surgical technique of wherein the pre- ...

BONE GRAFT MATERIALS AND METHODS

Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size. 1. A bone graft composition comprising:about 15% to about 20% by weight collagen;about 55% to about 70% by weight bioactive glass, the bioactive glass including particles within a range of about 53 μm to about 425 μm in size, at least 85% of the bioactive glass particles being within a range of 212 μm to 425 μm in size; andabout 15% to about 30% by weight calcium phosphate.2. The bone graft composition of claim 1 , wherein the bioactive glass particles and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition.3. The bone graft composition of claim 1 , wherein the collagen is type I collagen.4. The bone graft composition of claim 1 , wherein the bioactive glass includes particles having a smooth surface.5. The bone graft composition of claim 1 , wherein the calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite.6. The bone graft composition of claim 5 , further comprising about 15% by weight type I collagen claim 5 , about 55% to about 65% by weight bioactive glass claim 5 , and about 20% to about 30% by weight calcium phosphate.7. The ...

MULTI-PIECE INTERVERTEBRAL IMPLANTS

Intervertebral implants for implanting into an intervertebral space are provided. The implants can comprise one or more layers that are operably attached to one another. An implant can comprise a first layer having a first mating surface that mates with a second mating surface of a second layer. The first mating surface and the second mating surface can have features that allow them to complement each other. The implants can include one or more bore holes for receiving a fixation member. The bore holes can be horizontal, vertical or diagonal. In some cases, the bore holes will be blind bore holes. 1. An intervertebral implant comprising:an inner member comprising a central opening;a first lateral member, wherein the first lateral member comprises a curved surface that conforms to a first outer wall of the inner member;a second lateral member, wherein the second lateral member comprises a curved surface that conforms to a second outer wall of the inner member; anda first pin extending between the inner member and the first lateral member; anda second pin extending between the inner member and the second lateral member.2. The implant of claim 1 , wherein the inner member claim 1 , first lateral member and second lateral member are each formed of bone.3. The implant of claim 1 , wherein when the inner member claim 1 , first lateral member and second lateral member are assembled claim 1 , the implant includes a planar anterior surface.4. The implant of claim 3 , wherein when the inner member claim 3 , first lateral member and second lateral member are assembled claim 3 , the implant further includes a planar posterior surface.5. The implant of claim 1 , further comprising a third pin extending through the inner member and the first lateral member claim 1 , and a fourth pin extending through the inner member and the second lateral member.6. The implant of claim 1 , wherein when the inner member claim 1 , first lateral member and second lateral member are assembled claim ...

INTERBODY DEVICE AND PLATE FOR SPINAL STABILIZATION AND INSTRUMENTS FOR POSITIONING SAME

Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned. 123-. (canceled)24. A system comprising:a plate including a body having a top surface and an opposite bottom surface, the body including a plurality of holes extending through the top and bottom surfaces, trajectories of each of the holes extending toward a common point above the plate, the plate including a retaining element comprising arms that are separated by gaps, the retaining element being rotatable between a first position where the gaps are aligned with the holes and a second position where the arms overlap the holes.25. A system as recited in claim 24 , wherein each of the holes is configured for disposal of a bone screw such that the bone screw extends obliquely through and away from the body.26. A system as recited in claim 24 , wherein:at least one of the holes is configured for disposal of a bone screw such that the bone screw extends obliquely through and away from the body in a lateral, cephalad direction; andat least one of the holes is configured for disposal of a bone screw such that the bone screw extends obliquely through and away from the ...

IMPLANTS FOR BONE AND CARTILAGE REPAIR

An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant. 1. A biocompatible and bioresorbable implant having a physically and mechanically stable bi-phasic structure for the repair of bone and cartilage , comprising a cell conductive zone that contains a first matrix including first biopolymeric fibers , and an osteoconductive zone that contains a second matrix including second biopolymeric fibers and calcium-containing mineral particles , wherein the first biopolymeric fibers in the first matrix are derived from tendon or dermis , the cell conductive zone is free of calcium-containing mineral particles , the first biopolymeric fibers extend into the osteoconductive zone and overlap with the second biopolymeric fibers , and the cell conductive zone overlaps with and is in direct contact with the osteoconductive zone.2. The implant of claim 1 , wherein the first biopolymeric fibers include a protein.3. The implant of claim 2 , wherein the protein is a fibrillar collagen.4. The implant of claim 3 , wherein the collagen is type I collagen claim 3 , type II collagen claim 3 , or type III collagen.5. The implant of claim 1 , wherein the calcium-containing mineral particles include synthetic or natural calcium-containing compounds.6. The implant of claim 1 , wherein the first matrix has a density of 0.03 g/cmto 0.8 g/cmand a compressive modulus of 0.05 N/cmto 10 N/cm.7. The implant of claim 6 , wherein the shape of the implant is a circular cylinder.8. The implant of claim 7 , wherein the implant has a length of 0.3 cm to 2 cm and a diameter of 0.2 cm to 3 cm.9. The implant of claim 8 , wherein a content of ...

Method of deploying a percutaneous replacement heart valve

A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

SYSTEM AND METHOD TO FUSE BONE

A synthetic implant is provided that is operable to be disposed between and fuse two sections of a bone. The synthetic implant includes a synthetic material that is operable to abut against the two sections of the bone. The synthetic material is porous and/or fibrous and is operable to receive at least one cellular growth factor. The synthetic material can be combined with other synthetic materials or human bone tissue or animal bone tissue or other human or animal tissue that is suitable to act as a platform or scaffold on which new bone can grow or to cause bone to fuse together. 1. A fully synthetic implant operable to be disposed between and fuse two sections of a bone , the fully synthetic implant comprising:one or more synthetic materials operable to abut against the two sections of the bone, the synthetic material being porous and/or fibrous and operable to receive at least one carrier component.2. The fully synthetic implant of claim 1 , further comprising an inner layer and an outer layer claim 1 , wherein the inner layer and the outer layer are made of the one or more synthetic material claim 1 , wherein the outer layer includes a first portion and a second portion claim 1 , the inner layer is sandwiched between the first and second portions of the outer layer.3. The fully synthetic implant of claim 1 , wherein the synthetic material comprises at least one or more of:collagen and bioactive glass;bioactive monomers;newberyite; ora silica biomaterial.4. The fully synthetic implant of claim 1 , wherein the at least one carrier component includes a cellular growth factor claim 1 , a plasma rich protein claim 1 , bone marrow aspirate claim 1 , saline claim 1 , bone morphogenetic proteins claim 1 , mesenchymal stem cells claim 1 , blood claim 1 , osteoclasts claim 1 , osteoblasts claim 1 , antibiotics claim 1 , analgesics claim 1 , anticoagulates claim 1 , beta-tricalcium phosphate claim 1 , thrombin claim 1 , surgical glues claim 1 , demineralized bone matrix ...

IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME

An implantable tissue repair device for the repair, replacement or augmentation of a tissue, the device having a biocompatible solvated structural material, where at least part of the structural material is in a compressed and/or dried state. 1. An implantable tissue repair device for the repair , replacement or augmentation of a tissue , the device comprising a biocompatible solvated structural material , wherein at least part of the structural material is in a compressed and/or dried state.2. A device as claimed in wherein the part or parts are both compressed and dried.3. A device as claimed in comprising a body and one or more anchoring elements projecting from the body.4. A device as claimed in wherein the anchoring elements or a part thereof are compressed and/or dried.5. A device as claimed in wherein both the body and the anchoring elements are compressed and/or dried.6. A device as claimed in wherein the anchoring elements are integrally formed with the structural material of the body.7. A device as claimed in wherein the structural material is a hydrogel.8. A device as claimed in wherein the part or parts of the device which are in a compressed and/or dried state have dimensions no more than 95% of the part's or parts' original uncompressed and/or solvated state.9. A device as claimed in wherein the structural material comprises a material selected from silk fibroin claim 1 , fibrin claim 1 , fibronectin claim 1 , cellulose claim 1 , alginate claim 1 , hyaluronic acid claim 1 , gelatin and collagen.10. A device as claimed in further comprising a network of fibres located at least partially within the structural material.11. A device as claimed in wherein the fibres in the fibre network are formed from a biocompatible fibre material selected from silk claim 10 , cellulose claim 10 , alginate claim 10 , gelatin claim 10 , fibrin claim 10 , fibronectin claim 10 , hyaluronic acid claim 10 , chondroitin sulphate claim 10 , ceramic claim 10 , metal and alloy.12. ...

TISSUE ENGINEERED DEVICES AND METHODS FOR MAKING SAME

Tissue engineered constructs and methods for fabricating the disclosed constructs are provided. Some of the disclosed tissue engineered constructs are designed to fill a void in the body due to surgical resection, for example from mastectomy or lumpectomy, wounds and the like. Some disclosed constructs comprise one or more projections designed to mimic the appearance of a structural feature when implanted into a host. 1. A volume forming unit (VFU) comprising adipocytes and at least one projection.2. The VFU of claim 1 , wherein the VFU further comprises endothelial channels.3. The VFU of claim 1 , wherein the at least one projection is designed to simulate at least one structural feature of a nipple.4. The VFU of claim 3 , wherein a second projection is designed to simulate the at least one structural feature of an areola and the second projection circumscribes the at least one projection designed to simulate at least one structural feature of a nipple.5. A method for creating a VFU claim 3 , comprising:adding (i) a mixture comprising at least one biocompatible hydrogel material and a multiplicity of cells to (ii) a negative mold;incubating the mold under conditions suitable for hydrogel formation, thereby creating the VFU.6. The method of claim 5 , wherein the cells comprise at least one of adipocytes claim 5 , endothelial cells claim 5 , fibroblasts claim 5 , or mesenchymal stem cells.7. The method of claim 5 , wherein the mixture comprising at least one biocompatible hydrogel material and a multiplicity of cells comprises at least two solutions that may be added to the mold simultaneously or in any order.8. The method of claim 5 , wherein at least one component of the mixture is added to the mold using bioprinting.95. The method of claim 5 , wherein the at least one biocompatible hydrogel material comprises at least one of fibrinogen claim 5 , a fibrinogen activator claim 5 , or thrombin.10. The method of claim 5 , wherein:(a) the cells comprise at least one of ...

Engineered sterile cartilage allograft implant plug with sterile, specific instrument kit(s)

An apparatus and a method are provided for performing cartilage allograft implant surgeries. The apparatus comprises an allograft plug kit comprising one or more grafts configured to treat osteochondral defects in various bone joint locations in a patient's body. Each of the grafts comprises a cartilage layer coupled with a bone portion. The cartilage layer comprises a thickness selected to closely match the thickness of existing cartilage at an implant location. The bone portion comprises surface features configured to encourage the patient's bone tissue to grow into the bone portion, thereby accelerating incorporation of the graft into the patient's bone. An instrument kit comprises a multiplicity of instruments configured for implantation of the grafts into the patient's body, including at least a graft inserter, a guidewire, a reamer, and a size gauge.

PRE-ASSEMBLED BIOPROSTHETIC VALVE CONDUIT AND METHOD OF DELIVERY

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. 1. A pre-assembled valved conduit , comprising:a bioprosthetic valve including bioprosthetic tissue leaflets, the valve having been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve, the bioprosthetic valve having a sewing ring encircling an inflow end;a conduit sealed with a bioresorbable medium that is coupled to the sewing ring with sutures so as to form the valved conduit;a valve holder attached to the bioprosthetic valve on an outflow side thereof; andan elongated delivery handle connected to the valve holder and extending through the conduit so as to project from an outlet end thereof.2. The valved conduit of claim 1 , wherein the bioprosthetic valve is a heart valve located at an inlet end of the conduit that wraps around the sewing ring.3. The valved conduit of claim 2 , wherein the sutures coupling the conduit inlet end to the sewing ring pass through the entire sewing ring from inflow to outflow sides thereof.4. The valved conduit of claim 1 , wherein the bioprosthetic ...

Percutaneously implantable replacement heart valve device and method of making same

A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

Cortical Rim-Supporting Interbody Device

A central inflatable distractor and a perimeter balloon are inserted into the disc space in uninflated configurations. The central inflatable distractor is then expanded, thereby distracting the vertebral endplates to the controlled height of the central inflatable distractor. The perimeter balloon is then inflated with a curable substance. The perimeter balloon expands as it is filled with the curable substance and conforms to the void remaining in the disc space around the central inflatable distractor, thereby creating a horseshoe shape. Once the flowable material in the perimeter balloon has cured, the central inflated distractor can be deflated and removed. The remaining void (or inner space) is then packed with graft for fusion. 2. The method of wherein the distractor occupies the inner space defined by the balloon.3. The method of wherein the balloon is elastic.4. The method of wherein the balloon is inelastic and forms a predetermined shape when inflated.5. The method of wherein the balloon forms an annular shape.6. The method of wherein the balloon forms a substantially horseshoe-shape.7. The method of wherein the balloon wraps around the distractor so that an inner surface of the fusion balloon contacts an outer perimeter of the inflated distractor. This application claims priority from co-pending U.S. Ser. No. 14/039,628, filed Sep. 27, 2013, entitled “Cortical Rim-Supporting Interbody Device”, Lomeli et al, (Docket No. DSP5012USNP) which claims priority from provisional application No. 61/838,604, filed Jun. 24, 2013, Lomeli et al (Docket No. DSP5012USPSP) the specifications of which are incorporated by reference in their entirety.In an effort to treat low back pain, surgeon have removed the degenerative disc and inserted a fusion cage into the disc space. In an effort to minimize the invasiveness of the fusion procedure, more recent efforts have focused upon forming the fusion cage in-situ by flowing a curable material into a balloon that has been ...

Cortical Rim-Supporting Interbody Device

A central inflatable distractor and a perimeter balloon are inserted into the disc space in uninflated configurations. The central inflatable distractor is then expanded, thereby distracting the vertebral endplates to the controlled height of the central inflatable distractor. The perimeter balloon is then inflated with a curable substance. The perimeter balloon expands as it is filled with the curable substance and conforms to the void remaining in the disc space around the central inflatable distractor, thereby creating a horseshoe shape. Once the flowable material in the perimeter balloon has cured, the central inflated distractor can be deflated and removed. The remaining void (or inner space) is then packed with graft for fusion.

OSTEOGRAFT IMPLANT

Bone implant compositions are provided that include a body made of cortical bone extending along an axis between a first end and a second end. The body includes an outer surface configured to engage host bone of a patient and at least one recess extending transverse to the axis into the outer surface of the body configured for disposal of an insert. At least one insert made of demineralized bone is disposed in the at least one recess. 117.-. (canceled)18. An osteograft comprising: a body comprising cortical bone extending between a first end and a second end along an axis and including an outer surface configured to engage host bone of a patient , the body comprising an upper surface and a lower surface opposite the upper surface , the body including an inner surface defining an opening extending through the upper and lower surfaces , the upper and lower surfaces each including a plurality of recesses each having a circular cross-sectional configuration and extending perpendicular to the axis into the outer surface disposed circumferentially about the upper and lower surfaces , the inner surface including a plurality of recesses each having a circular cross-sectional configuration and extending parallel to the axis; and a plurality of plugs comprising demineralized bone each having a circular cross-sectional configuration disposed in one of the recesses , wherein the inner and outer surfaces are surface demineralized before the plugs are disposed into the recesses to promote chemical or cohesive bonding or mechanical press fit between the body and the plugs.19. The osteograft as recited in claim 18 , wherein the recesses are uniform and each have a maximum width that is greater than a maximum width of the plugs claim 18 , the plugs having a circular cross-sectional configuration.20. The osteograft as recited in claim 18 , wherein the plugs comprise demineralized bone matrix fibers and demineralized bone matrix powder in a ratio of 25:75 to about 75:25.21. The ...

Compositions Comprising Meniscal Tissues and Uses Thereof

Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue. 1. A composition comprising a meniscal tissue , wherein the meniscal tissue comprises one or more engineered channels.2. The composition of claim 1 , wherein the meniscal tissue comprises viable cells native to the meniscal tissue and devitalized blood vessels.3. The composition of claim 1 , wherein the meniscal tissue comprises greater than 30% viable non-immunogenic cells native to the meniscal tissue and less than 5% viable immunogenic cells.4. (canceled)5. The composition of claim 1 , wherein the meniscal tissue further comprises an altered red zone.6. The composition of claim 5 , wherein the meniscal tissue further comprises a red-white zone claim 5 , and white zone.7. The composition of claim 5 , wherein the meniscal tissue has an inner edge and an opposed outer edge claim 5 , and wherein the altered red zone has an outer surface that defines the outer edge of the meniscal tissue.8. The composition of claim 5 , wherein the altered red zone comprises blood vessel structures native to the red zone.9. The composition of claim 6 , wherein the altered red zone claim 6 , red-white zone ...

TENDON REPAIR IMPLANT AND METHOD OF ARTHROSCOPIC IMPLANTATION

A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time. 1. A tendon repair implant for repair of a tendon , the tendon repair implant comprising:an elongated sheet-like structure formed of reconstituted collagen material, the sheet-like structure having a first compact configuration for delivery from an arthroscopic instrument and a second planar configuration having a longitudinal dimension, a lateral dimension, and a thickness dimension and configured to be affixed to a surface of the tendon such that the longitudinal dimension of the sheet-like structure extends parallel to a load bearing direction of the tendon;wherein the reconstituted collagen material has a longitudinal alignment of collagen fibers forming longitudinal pathways extending along the longitudinal dimension of the sheet-like structure in the thickness dimension for at least some tissue in-growth oriented in the longitudinal direction, the longitudinal pathways having a cross-section width of 150 microns to 200 microns;wherein the sheet-like structure has an initial tensile modulus in the longitudinal dimension of 1 MPa to 10 MPa in the range of 1% to 3% strain prior to implantation, where 0% strain is defined with a 1 N preload applied to the sheet-like structure;wherein the sheet-like structure has an initial compressive modulus of at least 0.1 ...

NANOFIBROUS BIOLOGIC HEART VALVE LEAFLETS AND FIBROSA LAYER OF A LEAFLET

Systems and methods for producing biologic tissues are described. For example, this document provides electrospinning systems and culturing techniques to make biologic heart valve leaflets and fibrosa layers of native valve leaflet having nanofibrous substrate layer(s). In some implementations, a tri-layered leaflet with circumferentially, randomly, and radially oriented nanofibers that mimics morphologies of native leaflets. 1. A biologic heart valve leaflet comprising a synthetic trilayered nanofibrous substrate material that comprises:a first layer comprising a radially oriented nanofibrous substrate;a second layer comprising a randomly oriented nanofibrous substrate; anda third layer comprising a circumferentially oriented nanofibrous substrate,wherein the second layer is disposed on a surface of the first layer, and the third layer is disposed on a surface of the second layer.2. The biologic heart valve leaflet of claim 1 , wherein the first layer claim 1 , the second layer claim 1 , and the third layer are each made using an electrospinning process.3. The biologic heart valve leaflet of claim 1 , wherein the second layer is disposed on the surface of the first layer by electrospinning the second layer onto the surface of the first layer.4. The biologic heart valve leaflet of claim 3 , wherein the third layer is disposed on the surface of the second layer by electrospinning the third layer onto the surface of the second layer.5. The biologic heart valve leaflet of claim 1 , wherein the first layer claim 1 , the second layer claim 1 , and the third layer comprise nanofibers having diameters in a range from about 100 nm to about 2 μm.6. The biologic heart valve leaflet of claim 1 , wherein the nanofibers comprise one or more from the group consisting of polycaprolactone claim 1 , polyglycerol sebacate claim 1 , polyglycolic acid claim 1 , collagen claim 1 , and poly(lactide-co-glycolide).7. The biologic heart valve leaflet of claim 1 , further comprising at least ...

DOUBLE-STRUCTURED TISSUE IMPLANT AND A METHOD FOR PREPARATION AND USE THEREOF

A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment. 120-. (canceled)21. A tissue implant comprising:a primary scaffold comprising a first collagen and a plurality of pores; anda secondary scaffold comprising a second collagen, the secondary scaffold forming a fibrous and cross-linked collagen network within the plurality of pores.22. The tissue implant of claim 21 , wherein the secondary scaffold is a collagenous solution or gel comprising the second collagen and a surfactant.23. The tissue implant of claim 22 , wherein the collagenous solution or gel is lyophilized within the plurality of pores.24. The tissue implant of claim 22 , the surfactant is a non-ionic surfactant.25. The tissue implant of claim 24 , wherein the non-ionic surfactant is a polymeric compound.26. The tissue implant of claim 21 , wherein the first collagen comprises Type I collagen.27. The tissue implant of claim 26 , wherein the second collagen comprises Type I collagen.28. The tissue implant of claim 21 , wherein the second collagen comprises Type I collagen.29. The tissue implant of claim 21 , wherein the secondary scaffold comprises cells.30. The tissue implant of claim 21 , wherein the plurality of pores have a substantially homogeneous defined diameter.31. The tissue implant of claim 21 , wherein the primary scaffold has a substantially defined pore size in diameter and pore density that creates a top surface and a bottom surface to the tissue implant wherein the size and diameters of the pores on ...

Biocompatible containment member for bone augmentation surgery made of processed natural membrane from an animal donor

A surgically implantable containment member for maintaining a bone augmentation material in a desired location and/or configuration following implantation in a human or other mammalian patient, in which the containment member is made of a natural membrane, such as pericardium, isolated from an animal donor and processed to avoid inflammation or tissue rejection, and a method of bone augmentation using such a containment member. In a particularly preferred embodiment, the containment member has a window which rapidly dissipates upon exposure to bodily fluids after implantation to expose bone augmentation material contained within the containment member to an adjacent bone to be augmented.

DEVICES, SYSTEMS AND METHODS FOR TISSUE ENGINEERING OF LUMINAL GRAFTS

The disclosure of the present application provides devices, systems, and methods for replacing damaged or compromised blood vessels and engineering luminal grafts for various medical applications. Such devices are capable of providing viable, small-diameter grafts for use in anastomotic procedures and comprise a tubular construct consisting largely of elastin and some collagen fibers and having at least one diameter of less than or equal to about 5 mm. In one exemplary embodiment, the graft comprises at least one layer of pulmonary ligament tissue and/or pulmonary visceral pleura. Systems and methods for the manufacture of the graft are also provided, which include the use of at least one layer of tissue, a mandrel and a closure mechanism. 1. A luminal graft comprising a generally tubular element configured for plasma and/or blood cells to flow therethrough and comprising biological tissue having elastin fibers and collagen fibers , with the elastin fibers being a dominant component thereof.2. The luminal graft of claim 1 , wherein the biological tissue comprises a ratio of collagen fibers to elastin fibers ranging from about a 1.2 ratio value to about a 0.8 ratio value.3. The luminal graft of claim 1 , wherein:the generally tubular element comprises at least one layer, formed to define a proximal end, a distal end, and a lumen extending therebetween; andat least one of the layers comprises biological tissue.4. The luminal graft of claim 1 , wherein the biological tissue comprises pulmonary ligament tissue or visceral pleura tissue.5. The luminal graft of claim 1 , wherein the biological tissue comprises at or between about 11% and about 12% collagen fibers and at or between about 12.5% and 13.5% elastin fibers.68.-. (canceled)9. The luminal graft of :wherein each of the layers comprises a first edge and a second edge, both of which extend between the proximal and distal ends of the layer; andfurther comprising a seam extending between the proximal and distal ends ...

IMPLANTABLE COMPOSITE CONTAINING CARBONATED HYDROXYAPATITE

Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and β tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to tit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided. 1. An implantable composite comprising a plurality of resorbable ceramic particles , the resorbable ceramic particles comprising carbonated hydroxyapatite and tricalcium phosphate in a ratio from about 5:95 to about 70:30.2. An implantable composite of claim 1 , wherein the implantable composite comprises a biodegradable polymer and the tricalcium phosphate is β tricalcium phosphate.3. An implantable composite of claim 1 , wherein the resorbable ceramic particles are granules having an average diameter in the range from about 0.4 to about 3.5 mm.4. An implantable composite of claim 1 , wherein a resorption rate of the implantable composite containing the carbonated hydroxyapatite increases from about 10% to about 40% when compared to a resorption rate of an implantable composite having resorbable ceramic particles comprising hydroxyapatite and β tricalcium phosphate in a ratio from about 5:95 to about 70:30 but no carbonated hydroxyapatite.5. An implantable composite of claim 2 , wherein the biodegradable polymer comprises one or more poly(L-lactide-co-D claim 2 ,L-lactide) claim 2 , polyglyconate claim 2 , poly(acrylates) claim 2 , poly(anhydrides) claim 2 , poly(hydroxy acids) claim 2 , polyesters claim 2 , poly(orthoesters) claim 2 , poly(alkylene oxides) claim 2 , polycarbonates claim 2 ...

Cortical Rim-Supporting Interbody Device

A central inflatable distractor and a perimeter balloon are inserted into the disc space in uninflated configurations. The central inflatable distractor is then expanded, thereby distracting the vertebral endplates to the controlled height of the central inflatable distractor. The perimeter balloon is then inflated with a curable substance. The perimeter balloon expands as it is filled with the curable substance and conforms to the void remaining in the disc space around the central inflatable distractor, thereby creating a horseshoe shape. Once the flowable material in the perimeter balloon has cured, the central inflated distractor can be deflated and removed. The remaining void (or inner space) is then packed with graft for fusion. 1. A method of forming an interbody fusion cage , comprising the steps of;a) introducing an inflatable distractor into a disc space in an uninflated form,b) inflating the inflatable distractor with a biologically inert fluid to distract the disc space,c) introducing an inflatable balloon into the disc space,d) filling the inflatable balloon with a curable material;wherein at least one of the inflatable balloon and the inflatable distractor has a track associated therewith.2. The method of further comprising the step of:e) deflating the inflated distractor after the curable material has cured.3. The method of further comprising the step of:f) removing the deflated distractor from the disc space.4. The method of claim 3 , wherein the balloon has a substantially annular form defining an inner space claim 3 , further comprising the step of:g) filling the inner space with an osteogenic material.5. The method of wherein the distractor occupies the inner space defined by the balloon.6. The method of wherein the balloon is elastic.7. The method of wherein the balloon is inelastic and forms a predetermined shape when inflated.8. The method of wherein the balloon forms an annular shape.9. The method of wherein the balloon forms a substantially ...

MANUFACTURE OF BIOMATERIAL IMPLANTS VIA THREE-DIMENSIONAL PRINTING TECHNOLOGY

The present invention relates to the manufacture of shaped biomaterial-based implants via three-dimensional printing technology. 1. A method of generating a three-dimensional biomaterial-based implant , comprising:visualizing an implantation site;producing a mold comprising dimensions of the implantation site by three-dimensional printing; andplacing a biomaterial in the mold to form the biomaterial-based implant.2. The method of claim 1 , wherein the visualization is selected from at least one of X-ray claim 1 , ultrasound claim 1 , CT imaging claim 1 , and MRI imaging.3. The method of claim 1 , wherein the visualization of the implantation site comprises imaging implantation sites in multiple patients.4. The method of claim 3 , wherein the imaging multiple implantation sites in the multiple patients provides a representative image of an implantation site type.5. The method of claim 1 , wherein the visualization of the implantation site occurs by imaging the implantation site of a single patient.6. The method of claim 1 , wherein a shape of the three-dimensional biomaterial-based implant is comprised of at least one of biomaterial powder claim 1 , fibers claim 1 , particles claim 1 , shards claim 1 , and strips.7. The method of claim 1 , wherein the biomaterial is selected from the group consisting of bone claim 1 , connective tissue claim 1 , tendon claim 1 , pericardium claim 1 , dermis claim 1 , cornea claim 1 , dura matter claim 1 , fascia claim 1 , heart valve claim 1 , ligament claim 1 , capsular graft claim 1 , cartilage claim 1 , collagen claim 1 , nerve claim 1 , placental tissue claim 1 , and combinations thereof.8. The method of claim 7 , wherein the biomaterial is bone and wherein the bone material is at least one of cortical claim 7 , cancellous or a combination thereof.9. The method of claim 7 , wherein the biomaterial is bone claim 7 , and wherein the bone is at least one of demineralized claim 7 , partially demineralized claim 7 , or fully ...

INTRABODY OSTEOTOMY IMPLANT AND METHODS OF USE

An intrabody implant disclosed and methods of use are disclosed. The implant has an inclined surface, forming a wedge shape having an acute angle adapted to be placed between at least 2 separated portions of a single bony structure (such as a vertebral body). In some embodiments, the implant may be used to support portions of a vertebral body that have been separated surgically as part of a pedicle subtraction osteotomy and to orient the portions at a more predictable lordotic angle. 1. An intrabody implant adapted to be placed between at least 2 separated portions of a single bony structure , the intrabody implant comprising:a first surface configured for engaging a first of the at least two separated portions of the bony structure;a second surface, disposed opposite the first surface, and configured for engaging a second of the at least two separated portions of the bony structure, the second surface disposed at an acute angle relative to the first surface;a wall disposed between the first and second surfaces, the wall comprising an anterior portion and a posterior portion, the posterior portion having a posterior height and the anterior portion having an anterior height, the posterior and anterior heights being unequal to form the acute angle between the first surface and the second surface.2. An intrabody implant as recited in wherein the first and second surfaces define an aperture extending through the implant to allow for bone growth through the implant from the first portion of the bony structure to the second portion of the bony structure.3. An intrabody implant as recited in claim 1 , wherein the posterior height is less than the anterior height such that the acute angle of the intrabody implant introduces a lordotic angle between the first and second portions of the bony structure.4. An intrabody implant as recited in claim 1 , wherein the acute angle is between 10 degrees and 30 degrees.5. An intrabody implant as recited in wherein the posterior portion ...

CARTILAGE MOSAIC COMPOSITIONS AND METHODS

Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided. 143-. (canceled)44. A mosaic cartilage composition comprising:a 1 mm thick cartilage sheet comprising a plurality of interconnected cartilage tiles that are separated by perforations formed in the cartilage sheet, the perforations having an average diameter of 5-100 microns; anda cryopreservation medium.45. The mosaic cartilage composition of claim 44 , wherein the cartilage is articular cartilage.46. The mosaic cartilage composition of claim 44 , wherein the cartilage is non-decellularized cartilage.47. The mosaic cartilage composition of claim 44 , wherein the cartilage is from a human adult cadaveric donor age 15 years or older.48. The mosaic cartilage composition of claim 44 , wherein the cartilage is from a human juvenile cadaveric donor.49. The mosaic cartilage composition of claim 44 , wherein the tiles are square or rectangular or circular in shape.50. The method of claim 49 , wherein the tiles that are circular in shape have an average diameter from about 0.5 mm to about 3 mm.51. The method of claim 49 , wherein the tiles that are square or rectangular in shape have an average length and/or width from about 0.5 mm to about 3 mm.52. The mosaic cartilage composition of claim 44 , wherein the cryopreservation medium comprises dimethyl sulfoxide (DMSO) and serum.53. The mosaic cartilage composition of claim 44 , wherein the cryopreservation medium comprises a cryoprotective agent claim 44 , the cryoprotective agent comprising at least one of glycerol claim 44 , DMSO claim 44 , hydroxyethyl starch claim 44 , polyethylene glycol claim 44 , propanediol claim 44 , ethylene glycol claim 44 , butanediol claim 44 , or polyvinylpyrrolidone.54. The mosaic cartilage composition of ...

Implantable tissue repair devices and methods for manufacturing the same

Interbody device and plate for spinal stabilization and instruments for positioning same

Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Patient-specific guide for partial acetabular socket replacement

A device for partial acetabular replacement includes a patient-specific acetabular guide. The acetabular guide has a first surface configured to nestingly mate in only one position to the patient's acetabulum. The acetabular guide includes a patient-specific guiding formation configured to guide a cutting tool to remove damaged tissue from a defect of the patient's acetabulum and prepare a patient-specific implantation slot corresponding to the defect after removal of the damaged tissue. A patient-specific partial acetabular implant can be configured to nestingly mate with the patient-specific implantation slot.

Patient-specific guide for partial acetabular socket replacement

A device for partial acetabular replacement includes a patient-specific acetabular guide. The acetabular guide has a first surface configured to nestingly mate in only one position to the patient's acetabulum. The acetabular guide includes a patient-specific guiding formation configured to guide a cutting tool to remove damaged tissue from a defect of the patient's acetabulum and prepare a patient-specific implantation slot corresponding to the defect after removal of the damaged tissue. A patient-specific partial acetabular implant can be configured to nestingly mate with the patient-specific implantation slot.

Isolating and purifying cells for therapy

The present invention provides methods and devices for isolating cells from a subject by circulating the subject's body fluid over an affinity moeity coupled matrix to isolate isolate cells from a subject either ex vivo or in vivo. One aspect of the invention is directed to connecting a subject to a system capable of circulating the subject's body fluid through an affinity moiety coupled matrix, such that the affinity moiety coupled matrix is capable of binding to and extracting target cells from the body fluid, and then eluting the target cells from the affinity moiety. Another aspect of the invention is directed to the apparatus for isolating cells from a subject, comprising a blood circulation system with an arterial side blood circuit for extracting blood and flowing the blood over an affinity moiety coupled matrix that binds to and extracts target cells and a venous side blood circuit for returning the blood to the patient. The invention is also directed to in vivo seeding of biomatrials by implanting the affinity moiety coupled matrix in a subject to attract and bind the target cells in vivo.

Isolating and purifying cells for therapy

The present invention provides methods and devices for isolating cells from a subject by circulating the subject's body fluid over an affinity moeity coupled matrix to isolate cells from a subject either ex vivo or in vivo. One aspect of the invention is directed to connecting a subject to a system capable of circulating the subject's body fluid through an affinity moiety coupled matrix, such that the affinity moiety coupled matrix is capable of binding to and extracting target cells from the body fluid, and then eluting the target cells from the affinity moiety. Another aspect of the invention is directed to the apparatus for isolating cells from a subject, comprising a blood circulation system with an arterial side blood circuit for extracting blood and flowing the blood over an affinity moiety coupled matrix that binds to and extracts target cells and a venous side blood circuit for returning the blood to the patient. The invention is also directed to in vivo seeding of biomatrials by implanting the affinity moiety coupled matrix in a subject to attract and bind the target cells in vivo.

Injectable fibrin composition for bone augmentation

The present invention relates to a biodegradable injectable composition for bone augmentation comprising fibrin, a contrast agent and calcium salt-containing particles, as well as a method for bone augmentation in a patient suffering from a bone disorder comprising injecting said composition into a non-mineralized or hollow portion of said bone.

Orthopedic implant

Medical implant for gas exchange

Die Erfindung betrifft ein medizinisches Implantat zur Behandlung von Knochendefekten aufweisend einen Hohlkörper (1), der einen Innenraum im Inneren des Hohlkörpers (1) begrenzt, eine Fluidzuleitung (2), die mit dem Innenraum des Hohlkörpers (1) fluiddurchlässig verbunden ist, eine Fluidableitung (3), die mit dem Innenraum des Hohlkörpers (1) fluiddurchlässig verbunden ist, wobei der Hohlkörper (1) zumindest bereichsweise oder vollständig aus zumindest einem Kunststoff besteht, wobei der zumindest eine Kunststoff für Flüssigkeiten undurchlässig ist und für Sauerstoff und für Kohlendioxid durchlässig ist, so dass Sauerstoff aus einem durch den Hohlkörper (1) geleiteten Fluid an die Umgebung des Hohlkörpers (1) abgebbar ist und Kohlendioxid aus der Umgebung des Hohlkörpers (1) in das Fluid aufnehmbar ist.Die Erfindung betrifft auch ein Knochendefektbehandlungssystem aufweisend ein solches medizinisches Implantat und das Fluid, wobei das Fluid Sauerstoff enthält und zur Aufnahme von Kohlendioxid geeignet ist, und ein Verfahren zum Begasen einer Oberfläche eines medizinischen Implantats. The invention relates to a medical implant for treating bone defects, comprising a hollow body (1) which delimits an interior space in the interior of the hollow body (1), a fluid supply line (2) which is connected to the interior of the hollow body (1) in a fluid-permeable manner, a fluid discharge line (3), which is connected to the interior of the hollow body (1) in a fluid-permeable manner, the hollow body (1) at least partially or completely consisting of at least one plastic, the at least one plastic being impermeable to liquids and permeable to oxygen and carbon dioxide so that oxygen can be released from a fluid passed through the hollow body (1) to the surroundings of the hollow body (1) and carbon dioxide can be absorbed into the fluid from the surroundings of the hollow body (1). The invention also relates to a bone defect treatment system having such a medical one The ...

Particulate cartilage system

A cartilage treatment composition comprising: cadaveric, allogenic human cartilage particles from a human donor less than fifteen years of age at the time of donation including viable chondrocytes; and a matrix, wherein the matrix is defined as a chondroconductive media.

Method of treating an osteochondral defect

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Particulate cartilage system

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Cadaveric allogenic human juvenile cartilage implant

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Juvenile cartilage composition

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Particulate cadaveric allogenic cartilage system

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Patent JPS56501129A

Pre-assembled bioprosthetic valve and sealed conduit

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.

Pre-assembled bioprosthetic valve and sealed conduit

A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.

Porous substrates for implantation

A porous substrate or implant for implantation into a human or animal body constructed from a structural material and having one or more regions which when implanted are subjected to a relatively lower mechanical loading. The region(s) are constructed with lesser mechanical strength by having a lesser amount of structural material in said region(s) relative to other regions. This is achieved by controlling pore volume fraction in the regions.

Injectable fibrin composition for bone augmentation

本发明涉及一种生物可降解的用于骨质增加的可注射组合物，其包含纤维蛋白、造影剂和含有钙盐的颗粒。本发明还涉及一种用于在患有骨疾病的病人体内骨质增加的方法，包含将所述组合物注入所述骨质的未矿化部分或空心部分。

Orthopedic implants

本发明涉及一种植入物，其由以下组成：‑由纤维和基质组成的表面层，该表面层具有彼此相对的第一表面和第二表面，并且具有至多为所述表面层的最大尺寸的5％的厚度；‑多孔的生物可降解部分，该多孔的生物可降解部分具有彼此相对的第一表面和第二表面并且具有1‑8mm的厚度，其中其第一表面附着于表面层的第二表面；和‑由胶原蛋白制成的膜层，该膜层具有彼此相对的第一表面和第二表面，其中其第一表面附着至多孔部分的第二表面且不覆盖多孔部分的边缘；其中其第一表面附着至多孔部分的第二表面，其中多孔部分包括选自由生物活性玻璃、生物活性陶瓷、羟基磷灰石、磷酸三钙及其混合物组成的组的材料。

ORTHOPEDIC IMPLANT

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2018 104 678 A (51) МПК A61F 2/28 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2018104678, 01.07.2016 (71) Заявитель(и): СКУЛЛЕ ИМПЛАНТС ОЙ (FI) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): ВАЛЛИТТУ Пекка (FI) 08.07.2015 EP 15175784.6 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 08.02.2018 R U (43) Дата публикации заявки: 08.08.2019 Бюл. № 22 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2017/005637 (12.01.2017) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" R U (57) Формула изобретения 1. Имплант, состоящий из - поверхностного слоя, состоящего из волокон и матрицы, имеющего первую поверхность и вторую поверхность, противоположные друг другу, и имеющего толщину, которая составляет самое большее 5% от наибольшего размера поверхностного слоя, - пористой биоразрушаемой части, имеющей первую поверхность и вторую поверхность, противоположные друг другу, первая поверхность которой прикреплена ко второй поверхности поверхностного слоя, и имеющей толщину 1-8 мм, и - мембранного слоя, выполненного из коллагена, имеющего первую поверхность и вторую поверхность, противоположные друг другу, первая поверхность которого прикреплена ко второй поверхности пористой части без покрытия краев пористой части, причем пористая часть содержит материал, выбранный из группы, состоящей из биоактивного стекла, биоактивной керамики, гидроксиапатита, трикальцийфосфата и их смесей. 2. Имплант по п.1, в котором поверхностный слой является небиоразрушаемым. 3. Имплант по п.1 или 2, в котором матрица выполнена из полимера, выбранного из группы, состоящей из сложных полиэфиров, эпоксидов, акрилатов и их смесей. 4. Имплант по любому из пп.1-3, в котором полимер матрицы выбран из группы, состоящей из замещенных и незамещенных диметакрилатов и метакрилатов. Стр.: 1 A 2 0 1 8 1 0 4 6 7 8 (54) ...

COLLAGEN-CONTAINING MEDICAL NAPKIN FOR RAS AND METHOD FOR ITS MANUFACTURE

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2017 132 860 A (51) МПК A61L 27/42 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2017132860, 11.01.2016 (71) Заявитель(и): БОТИСС БИОМАТИРИАЛЗ ГМБХ (DE) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): БИЛЕНШТАЙН Оливер (DE), ТАДИК Драцен (DE) 24.02.2015 DE 10 2015 102 598.1; 16.11.2015 DE 10 2015 119 776.6 09 R U (43) Дата публикации заявки: 25.03.2019 Бюл. № (85) Дата начала рассмотрения заявки PCT на национальной фазе: 25.09.2017 EP 2016/050364 (11.01.2016) (87) Публикация заявки PCT: R U Адрес для переписки: 109012, Москва, ул. Ильинка, 5/2, ООО "Союзпатент" (54) КОЛЛАГЕНСОДЕРЖАЩАЯ МЕДИЦИНСКАЯ САЛФЕТКА ДЛЯ РАН И СПОСОБ ЕЁ ИЗГОТОВЛЕНИЯ (57) Формула изобретения 1. Способ изготовления имплантата, в частности медицинской салфетки для ран, при этом изделие плоской формы из магния или его сплава покрывают коллагенсодержащей композицией и сушат. 2. Способ изготовления имплантата по п. 1, отличающийся тем, что в качестве коллагенсодержащей композиции применяют коллагенсодержащую суспензию. 3. Способ изготовления имплантата по п. 2, отличающийся тем, что суспензию применяют с природным коллагеном. 4. Способ изготовления имплантата по любому из пп. 1-3, отличающийся тем, что изделие плоской формы из магния или его сплава выполняют в виде сетки. 5. Способ изготовления имплантата по любому из пп. 1-4, отличающийся тем, что изделию плоской формы из магния или его сплава придают устойчивую форму. 6. Способ изготовления имплантата по любому из пп. 1-5, отличающийся тем, что изделие плоской формы из магния или его сплава наносят на подложку. 7. Способ изготовления имплантата по любому из пп. 1-6, отличающийся тем, что в качестве подложки применяют коллагеновую мембрану, в частности, лиофилизированную кожу животного или человека. Стр.: 1 A 2 0 1 7 1 3 2 8 6 0 A WO 2016/134866 (01.09.2016) 2 0 1 7 1 3 2 8 6 0 (86) Заявка PCT: A 2 0 1 7 1 3 2 8 6 0 R U A 2 0 1 7 1 3 2 8 6 ...

Element for helping bone tissue and/or connective tissue growing into it and proliferating and method for manufacturing it

FIELD: medical engineering. SUBSTANCE: device has element like grain promoting bone tissue and/or connective tissue to grow into and proliferate. The element is composed of plastic and insignificantly flexible biologically compatible material preferentially metal or metal alloy. The element is porous and has the following porosity properties: a) porosity is uniform; b) internal dimensions of pocket cavities (recesses) and canals connecting them to each other are 50 mcm in width for bone tissue and more than a value like 10 mcm for connective tissue. Method for producing the element involves forcing gas through molten metal by bubbling with automatic separation of grains or granules not satisfying requirements on porosity. The internal dimensions of pocket cavities (recesses) and canals/passages connecting them to each other are 50 mcm in width in this case. EFFECT: increased bone tissue growth rate. 12 cl, 3 dwg па (19) ВИ "” 2 222 290 ^^ С2 (51) МПК’ Дб 2/28, 2/00, 2/30, А 61 . 27/02, 27/56 РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (72) Изобретатель: БРУСЕ Ингрид (3Е), БРУСЕ Ларс (ЗЕ) (21), (22) Заявка: 2001132074/14, 28.04.2000 (24) Дата начала действия патента: 28.04.2000 (73) Патентообладатель: (30) Приоритет: 28.04.1999 ЗЕ 9901523-2 БРУСЕ МЕДИКАЛ АБ (3Е) (46) Дата публикации: 27.01.2004 (74) Патентный поверенный: Егорова Галина Борисовна (56) Ссылки: ЦЗ 5217496 А, 08.06.1993. 4$ 5676700 А, 14.10.1997. КУ 2152192 СЛ, 10.07.2000. С 2 (85) Дата перевода заявки РСТ на национальную фазу: 28.11.2001 (86) Заявка РСТ: ЗЕ 00/00802 (28.04.2000) (87) Публикация РСТ: М/О 00/64504 (02.11.2000) (98) Адрес для переписки: 129010, Москва, ул. Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Н.Г. Лебедевой 2222290 (54) ЭЛЕМЕНТ ДЛЯ ОБЕСПЕЧЕНИЯ ВРАСТАНИЯ И РОСТА КОСТНОЙ ТКАНИ И/ИЛИ СОЕДИНИТЕЛЬНОЙ ТКАНИ И СПОСОБ ИЗГОТОВЛЕНИЯ ТАКОГО ЭЛЕМЕНТА КО (57) соединительной ткани. В соответствии со ...

Tendon repair implant and method of arthroscopic implantation

A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.

Devices and methods for mixing and extruding medically useful compositions

This invention provides devices and methods for mixing and extruding compositions which are medically and non-medically useful. The devices are particularly useful for mixing substances which are relatively inert when alone but become reactive when mixed. A common feature of all of the devices is that they allow the user to mix and ultimately extrude a composition from a single device which includes a single container or multiple interconnected containers.

Collagen / porous polymeric matrix biocomposite material and its use as an implant for repairing meniscal lesions of the knee and / or preventing or treating osteoarthritis of the knee

L’invention concerne un matériau biocomposite poreux comprenant une matrice polymérique possédant des pores définis par plusieurs surfaces et du collagène qui recouvre totalement ou partiellement les surfaces des pores et les surfaces externes de la matrice polymérique, le rapport, en poids, du collagène sur la matrice polymérique étant de 20/80 à 40/60. La matrice polymérique du matériau biocomposite poreux comprend un copolymère qui est préparé à partir d’un poly(ε-caprolactone) diol, d’un poly(lactide-co-glycolide) diol et d’une lysine diisocyanate (LDI). L’invention concerne également un implant qui est mousse poreux, biodégradable, et à biomécanique proche du ménisque normal, avec résistance à la traction, à la pression et à la déchirure, et empêchant les pores de se collaber sous la pression condyle-tibia. Il sert d'échafaudage pour la réparation ou le remplacement du ménisque détruit, indiquée dans l’arthrose terminale grade 3 ou 4 du genou, pour la prévention ou le traitement, par régénération de cartilage, de l’arthrose évoluée du genou, pour éviter la prothèse de genou chez le patient jeune. L'implant de la présente invention est biocompatible ainsi que les produits de dégradation. La présente invention propose également un procédé de fabrication de ces implants biocompatibles The invention relates to a porous biocomposite material comprising a polymeric matrix having pores defined by several surfaces and collagen which completely or partially covers the surfaces of the pores and the external surfaces of the polymeric matrix, the ratio, by weight, of collagen to the surface. polymeric matrix being from 20/80 to 40/60. The polymer matrix of the porous biocomposite material comprises a copolymer which is prepared from a poly (ε-caprolactone) diol, a poly (lactide-co-glycolide) diol and a lysine diisocyanate (LDI). The invention also relates to an implant which is porous, biodegradable, and biomechanical foam close to the normal meniscus, with tensile ...

Optically transparent biocompatible polymeric material mainly containing collagen and its manufacturing method

본 발명은 텔로-콜라겐과 그래프트-중합된 소수성 및 친수성 아크릴 및/또는 알렐 단량체 혼합물의 공중합 생성물을 포함하는 생체적합성 중합체에 관한 것이다. 본 발명의 물질은 변형성 렌즈, 예컨대 아페키아, 원시 및 근시를 교정하는데 유용한 안내 렌즈, 굴절 안내 콘택트 렌즈 및 표준 콘택트 렌즈의 제조에 유용하다. The present invention relates to a biocompatible polymer comprising a copolymerization product of a telo-collagen and a graft-polymerized hydrophobic and hydrophilic acrylic and / or allel monomer mixture. The materials of the present invention are useful in the production of deformable lenses such as apecia, intraocular lenses, refractive intraocular contact lenses and standard contact lenses useful for correcting hyperopia and myopia.

Interbody device and plate for spinal stabilization and instruments for positioning same

Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Wound dressing containing collagen and preparation method thereof

本发明涉及制备植入物的方法，所述植入物特别构成伤口敷料。所述植入物由镁制得的片状物构成，其植入胶原非机织物中。

Biocompatible optically transparent polymeric material based upon collagen and method of making

The present invention is biocompatible polymer containing the copolymerization product of a mixture of hydrophobic and hydrophilic acrylic and/or allelic monomers, graft-polymerized with telo-collagen. The present material is useful in the production of deformable lenses, for example, intraocular lenses, refractive intraocular contact lenses, and standard contact lenses useful, for example, for correcting aphekia, myopia and hypermetropia.

Grain for providing ingrowth and growth of bone tissue and/or connective tissue and method of making such a grain

골조직 및/또는 결합조직의 내생 및 성장을 제공하기 위한, 입자와 같은 보디가 제공된다. 상기 보디는 플라스틱 또는 비필수적으로 탄성인 생체적합성 재료, 바람직하게는 금속 또는 금속 합금으로 구성된다. 보디는 또한 다공성이며, 하기의 다공성 특성을 가진다: (a) 다공성이 연속적이고, (b) 공동/만입/포켓의 구멍 및 공동/만입/포켓을 상호연결하는 관/통로의 구멍이 골조직에 대해서는 약 50㎛를 초과하고, 결합조직에 대해서는 약 10㎛를 초과하는 폭을 가진다. 이러한 물제를 제조하는 방법에 있어서, 보디는 금속의 용융물로 기체를 취입시켜 제조된다. 본 발명에 따른 보디의 유리한 용도는 이것을 구멍이 형성된 케이스내에 넣어 척추 이식편과 같은 이식편을 제조하는 것이다.

Prosthetic nucleus apparatus and methods

Prosthetic nucleus apparatus (10) and methods for treating an intervertebral disc are disclosed. Prosthetic nucleus apparatus (10) may include a barrier sealant membrane (12) and a prosthetic nucleus material (14). The barrier sealant membrane (12) forms a chamber (24) which can receive the prosthetic nucleus material (14). The barrier sealant membrane (12) can be formed by depositing a layer of material on a tissue surface (102) within a de-nucleated space (104) within an intervertebral disc (100). The prosthetic nucleus material (14) may be positioned within the chamber (24) of the barrier sealant membrane (12) after the barrier sealant membrane (12) is deposited within the de-nucleated space (104). The barrier sealant membrane (12) and the prosthetic nucleus material may be positioned within a patient through an axial trans-sacral bore (410). A plug 16 may also be included to prevent expulsion of the barrier sealant membrane (12) and prosthetic nucleus material (14).

Orthopedic implant

Particulate cartilage system

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Multi-layered biomimetic material and method of formation

Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.

Biocompatible containment member for bone augmentation surgery made of processed natural membrane from an animal donor

A surgically implantable containment member for maintaining a bone augmentation material in a desired location and/or configuration following implantation in a human or other mammalian patient, in which the containment member is made of a natural membrane, such as pericardium, isolated from an animal donor and processed to avoid inflammation or tissue rejection, and a method of bone augmentation using such a containment member. In a particularly preferred embodiment, the containment member has a window which rapidly dissipates upon exposure to bodily fluids after implantation to expose bone augmentation material contained within the containment member to an adjacent bone to be augmented.

Intervertebral disc treatment devices and methods

Intervertebral disc treatment devices and methods are provided. An intervertebral disc treatment device (11) includes a fibrous body sized for introduction into a disc cavity (43) of a damaged disc wherein the body incorporates an effective amount of a tissue growth factor. Intervertebral disc treatment apparatuses are also described that include such a disc treatment device in combination with a delivery apparatus for retaining and selectively releasing the device into the disc cavity (43). Methods for treatment include providing a disc treatment device (11) as described above and inserting the device into an opening (44) in an annulus fibrous (42) and into the disc cavity (43). The methods further include stimulating tissue growth within the disc cavity (43) of the intervertebral disc (41).

Material for a bioresorbable implant, bioresorbable implant and method of making a bioresorbable implant

A material for a bioresorbable implant and/or a bioresorbable implant is described. The material and implant comprise a collagen solution or a collagen and one or more magnesium wire to provide a collagen-based composite membrane; wherein the one or more magnesium wire is coated and/or surface modified with tannic acid. A method of making the bioresorbable implant and optionally a method of surgery comprising inserting the bioresorbable implant are also described. The one or more wires may be further coated and/or surface modified with Magnesium, optionally in the form of Mg-phenolic networks. The coating may advantageously result in pH neutralization and/or passivation of the one or more magnesium wires. The coating may be with a Mg-polyphenolic film and may form a porous oxide layer. The one or more wire may comprise a one layer; two layer; three layer or higher ordered layered pattern.

Implants having bone growth promoting agents contained within biodegradable materials

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants may include biodegradable polymer particles contained within biocompatible fibers. The biodegradable polymer particles may include bone growth promoting agents that are released as the particles degrade over time.

Enzyme-medicated modification of fibrin for tissue engineering

The invention provides fibrin-based, biocompatible materials useful in promoting cell growth, wound healing, and tissue regeneration. These materials are provided as part of several cell and tissue scaffolding structures that provide particular application for use in wound-healing and tissue regenerating. Methods for preparing these compositions and using them are also disclosed as part of the invention. A variety of peptides may be used in conjunction with the practice of the invention, in particular, the peptide IKVAV, and variants thereof. Generally, the compositions may be described as comprising a protein network (e.g., fibrin) and a peptide having an amino acid sequence that comprises a transglutaminase substrate domain (e.g., a factor XIIIa substrate domain) and a bioactive factor (e.g., a peptide or protein, such as a polypeptide growth factor), the peptide being covalently bound to the protein network. Other applications of the technology include their use on implantable devices (e.g., vascular graphs), tissue and cell scaffolding. Other applications include use in surgical adhesive or sealant, as well as in peripheral nerve regeneration and angiogenesis.

Intervertebral disc treatment devices and methods

Intervertebral disc treatment devices and methods are provided. An intervertebral disc treatment device includes a fibrous body sized for introduction into a disc cavity of a damaged disc wherein the body incorporates an effective amount of a tissue growth factor. Intervertebral disc treatment apparatuses are also described that include such a disc treatment device in combination with a delivery apparatus for retaining and selectively releasing the device into the disc cavity. Methods for treatment include providing a disc treatment device as described above and inserting the device into an opening in an annulus fibrous and into the disc cavity. The methods further include stimulating tissue growth within the disc cavity of the intervertebral disc.

Intervertebral disc treatment devices and methods

Intervertebral disc treatment devices and methods are provided. An intervertebral disc treatment device includes a fibrous body sized for introduction into a disc cavity of a damaged disc wherein the body incorporates an effective amount of a tissue growth factor. Intervertebral disc treatment apparatuses are also described that include such a disc treatment device in combination with a delivery apparatus for retaining and selectively releasing the device into the disc cavity. Methods for treatment include providing a disc treatment device as described above and inserting the device into an opening in an annulus fibrous and into the disc cavity. The methods further include stimulating tissue growth within the disc cavity of the intervertebral disc.

Spondylolisthesis correction apparatus and method

An apparatus and method are provided that allow for the realignment and stabilization of adjacent vertebrae. An implant of this invention both repositions adjacent vertebrae and remains in situ to maintain the new position. The implant has two halves which are interlocked such that they can slide horizontally with respect to each other. Movement of the implant halves and their respective positions are controlled by set screw within the implant. The implant includes radial anchors which fit into alignment slots made in the misaligned vertebra by the disclosed method. The set screws are used to advance the halves of the implant which in turn move the misaligned vertebrae back into correct positions. The correct position of the vertebrae is locked in place through a nut and a plate.

Enzyme-mediated modification of fibrin for tissue engineering

Matrices covalently bound to bidomain peptides or proteins, produced recombinantly or synthetically, contain a transglutaminase substrate domain and a bioactive factor. The bioactive factor is preferably a growth factor, such as VEGF, growth factors from the TGF-β superfamily, PDGF, human growth hormone, IGF, and ephrin. Particularly preferred growth factors are TGF-β1, BMP 2; VEGF 121 and PDGF AB. The matrix material is crosslinkable, and may form a gel. These compositions are useful for tissue repair and regeneration.

Multi-phasic solid implants for tissue repair

Pre-assembled bioprosthetic valve and sealed conduit

Condensed blood plasma derivative

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Particulate cartilage system

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.