УСТРОЙСТВО И СПОСОБ ОБЛУЧЕНИЯ ГЛАЗА

... 1. Устройство для облучения роговицы (2) глаза (1), включающее в себя, по крайней мере, следующие элементы:- кольцевую деталь (20), которая имеет выполненную концентрически вокруг продольной оси (3) устройства опорную поверхность (28, 30) с целью фиксации устройства на глазу (1),- канал для облучения (26) роговицы (2), находящийся внутри кольцевой детали (20),- причем опорная поверхность (28, 30) для крепления устройства размещается вне канала для облучения (26), отличающееся тем, что устройство далее включает- УФ-излучатель света (23), который в рабочем положении устройства для подачи света в канал для облучения (26) устанавливается внутри кольцевой детали (20).2. Устройство по п. 1, отличающееся тем, что кольцевая деталь (20) имеет базирующий элемент (22) для корпуса (34), в котором устанавливается УФ-излучатель света (23), причем в рабочем положении устройства каждая боковая стенка корпуса (34), если она дистально выступает за пределы кольцевой детали (20), представляет собой продолжение ...

In situ UV/RIBOFLAVIN ocular treatment system

USE OF ELECTROMAGNETIC RADIATION WITH THE TREATMENT OF SENSORY ORGANS

COMBINED HEATING UP WITH MICROWAVES AND COOLING OF THE SURFACE OF THE KORNEA

FOOD EQUIPMENT FOR BIPOLAR ELECTRODES TO KAPSULOTOMIE.

SYSTEM FOR THE CHANGE OF VISUAL ACUITY BY THERMAL MEANS

RF-ABLATION AND ULTRASONIC CATHETERS FOR THE PENETRATION OF CHRONIC TOTAL CATCHES

Device for dissecting an eye for the introduction of photosensitizer and method of refractive surgery

A device for dissecting an eye 10 for the introduction of photosensitizer into the cornea is presented with which laser radiation 26 is focused in the interior of the cornea to create cavitation bubbles, whereby channels 18 are created in the cornea through which the photosensitizer can be introduced into the cornea. Furthermore, a method for refractive surgery is disclosed utilizing a sensitizer for hardening corneal tissue by cross-linking. (Fig. 1) 30 M a ...

IMPROVED METHOD AND APPARATUS FOR PERFORMING CORNEAL RESHAPING TO CORRECT OCULAR REFRACTIVE ERRORS

Crosslinking control

A crosslinking control system, the use of the crosslinking control system, a laser system comprising the crosslinking control system, a crosslinking control method and a method for laser treatment are provided. The crosslinking control system comprises a photosensitizer providing unit, a light source configured to provide light having a wavelength suitable to activate the photosensitizer introduced into or applied onto the tissue for crosslinking, and a control computer.

Ultrasound directed cavitational methods and systems for ocular treatments

Methods and system provide a focused spot having a cross-sectional size within a range from about 50 um to about 200 um full width half maximum (FWHM); the corresponding cavitation can be similarly sized within similar ranges. The ultrasound beam can be focused and pulsed at each of a plurality of locations to provide a plurality of cavitation zones at each of the target regions. Each pulse may comprise a peak power within a range generating focal negative peak pressures within a range from about 10 MPa to about 80 MPa. While the treatment pulses can be arranged in many ways within a region, in many instances the pulses can be spaced apart within a region to provide intact tissue such as intact sclera between pulses.

Systems and methods for the treatment of eye conditions

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material.

Eye treatment system

A system (1) for treating and monitoring the condition of an eye (6) includes a light source, preferably a non-lasing LED (2), for irradiating the eye at a wavelength sufficient to reverse eye damage. The system also includes an excitation light source, preferably a non-lasing LED (4), for exciting fluorescence in the eye and a detector (22) for detecting fluorescence stimulated by the excitation LED (4). The system may also include a second non-lasing light source, preferably a non-lasing LED, for irradiating the eye; and a detector for detecting scatter of light from the eye. Methods for monitoring, diagnosis and treatment of eye conditions such as cataracts are also provided.

Intensity controllable hand-held surgical light

FLEXIBLE, AUTOMATED CAPSULORHEXIS DEVICE

A capsularhexis electrode device and corresponding insertion tool are disclosed. A flexible capsulorhexis electrode device comprises an elastomeric ring, first and second electrically conductive traces disposed at a first face of the elastomeric ring and extending concentrically around the elastomeric ring, and first and second electrically conductive connectors. The first and second electrically conductive connectors are electrically connected to the first and second traces, respectively, and are disposed at opposing points across the elastomeric ring from one another. An insertion tool includes first and second stretcher bars with connectors for mating to the electrode device. One of the stretcher bars translates relative to the other to elongate the flexible electrode device for insertion into the anterior chamber of the eye through a small incision.

FLEXIBLE, AUTOMATED CAPSULORHEXIS DEVICE

A capsularhexis electrode device and corresponding insertion tool are disclosed. A flexible capsulorhexis electrode device comprises an elastomeric ring, first and second electrically conductive traces disposed at a first face of the elastomeric ring and extending concentrically around the elastomeric ring, and first and second electrically conductive connectors. The first and second electrically conductive connectors are electrically connected to the first and second traces, respectively, and are disposed at opposing points across the elastomeric ring from one another. An insertion tool includes first and second stretcher bars with connectors for mating to the electrode device. One of the stretcher bars translates relative to the other to elongate the flexible electrode device for insertion into the anterior chamber of the eye through a small incision.

SYSTEM FOR EYE TRACKING DURING EYE TREATMENT

A corneal cross-linking system includes a light source configured to emit a photoactivating light. The system includes a spatial light modulator configured to receive the photoactivating light from the light source and provide a pixelated illumination. The spatial light modulator defines a maximum area for the pixelated illumination. The system includes a controller configured to cause the spatial light modulator to project a first pixelated illumination onto the cornea to photoactivate a cross-linking agent applied to a treatment area. The first pixelated illumination has an area that is smaller than the maximum area defined by the spatial light modulator. The controller is configured to determine movement of the cornea. In response to the movement, the controller controls the spatial light modulator to project a second pixelated illumination to the treatment area based on a translation and/or transformation of the first pixelated illumination to continue photoactivating the cross-linking ...

NARROW ANGLE ILLUMINATION RING FOR OPHTHALMIC SURGICAL LASER SYSTEM

A narrow angle illumination light source for an ophthalmic surgical laser system includes multiple light emitting diodes (LEDs), multiple corresponding ball lenses, multiple corresponding upper apertures located between the LEDs and the lenses (optional), and multiple corresponding lower apertures located below the lenses. The light passing through each upper aperture and corresponding lens forms a light cone having a defined divergence angle and cone axis angle; the light cone only illuminates the corneal and sclera of a docked eye without illuminating the patient's nose and orbit. The lower apertures may have distinctive shapes to aid video focusing. The multiple LEDs are distributed uniformly in the circle, and may be divided into multiple independently controllable segments which allows directional illumination. The LEDs also have controllable brightness to allow images of darker and brighter illuminations to be taken in short succession.

CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying cornea! structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications ...

CROSSLINKING CONTROL

A crosslinking control system, the use of the crosslinking control system, a laser system comprising the crosslinking control system, a crosslinking control method and a method for laser treatment are provided. The crosslinking control system comprises a photosensitizer providing unit, a light source configured to provide light having a wavelength suitable to activate the photosensitizer introduced into or applied onto the tissue for crosslinking, and a control computer.

APPARATUS FOR THE TREATMENT AND/OR PREVENTION OF CORNEAL DISEASES

In accordance with an aspect of the invention, an apparatus for the treatment and/or prevention of corneal diseases is provided, the apparatus comprising - an applicator head, the applicator head comprising a radiation source capable of exciting a non-toxic chromophore; and - a control operable to activate the radiation source to radiate; wherein at least one of the following two conditions is met: - the applicator head comprises a sensor capable of measuring a signal dependent on a position of the applicator head relative to the cornea; - the applicator head is configured to be in physical contact with the cornea; and wherein the control is operable to activate the radiation source to radiate depending on a signal measured by the sensor or to activate the radiation source when the applicator head touches the cornea, respectively.

FEED DEVICE FOR BIPOLAR ELECTRODES FOR CAPSULOTOMY

Summary A pulsed HF current is fed to a bipolar diathermy instrument for optimum execution of a section in capsulotomy. The pulse duration can constantly be altered between 3 ms and 11 ms, whereby a pause of 30 ms or 22 ms develops. This pause is sufficient to cool the instrument tip, Plushed with sodium chloride, in order to prevent the possibility of injury to adjacent tissue. The pulse repetition frequency is about 15 hz. The device necessary for the purpose includes pulse duration control (31) and HF oscillator (30). The HF current is synchronized by pulses from control (31) with AND gate (35). Amplifier (40) feeds handpiece (21) of the diathermy instrument by transformer (46). The required operation free from grounding is thereby assured.

DEVICE FOR THE DEFORMATION OF THE CORNEA/CALLOSITY.

CASE OF LIGHT FOR EYE EXAMINATION DEVICES.

СПОСІБ І ПРИСТРІЙ ДЛЯ ЛІКУВАННЯ МАКУЛЯРНОЇ ДИСТРОФІЇ

Винахід належить до медицини, зокрема до офтальмології, і може бути застосований при лікуванні макулярної дистрофії. Винахід стосується способу, який полягає у одночасному або послідовному опромінюванні ушкодженої ділянки сітківки ока пацієнта імпульсами квазімонохроматичного світла видимого та ближнього інфрачервоного діапазонів з енергією в імпульсі, що не перевищує 10-2 Дж. Також винахід стосується пристрою для лікування макулярної дистрофії, що містить джерело випромінювання, пристрій для формування заданої діаграми направленості випромінювання та пристрій для спрямовування випромінювання через зіницю ока на задану ділянку сітківки, блок живлення, блок індикації та керування режимами роботи джерела випромінювання, у якому джерелом випромінювання є принаймні один світлодіод.

SYSTEM AND METHOD FOR POSITIONING AN EYE THERAPY DEVICE

A system for aligning an eye therapy instrument over a selected area or feature of an eye provides an attachment element that is removably attached to a surface of an eye. A receiving element is coupled to the attachment element and movable relative to the attachment element. The receiving element includes a coupling element configured to operably couple an eye therapy instrument to the receiving element and adjustably move the eye therapy instrument into a selected position with respect to the attachment element. The system makes adjustments to ensure accurate delivery of treatment from the eye therapy device to areas of the eye. In one embodiment, the receiving element allows lateral adjustments to be made along one or more axes. Additionally or alternatively, the receiving element allows angular or rotational adjustments to be made about one or more axes.

HIGH-INTENSITY PULSED ELECTRIC FIELD VITRECTOMY APPARATUS WITH LOAD DETECTION

A high-intensity pulsed electric field (HIPEF) vitrectomy apparatus is disclosed. An exemplary apparatus includes a HIPEF probe comprising at least one electrode disposed at a distal end of the HIPEF probe, such that the distal end is configured for insertion into an eye. A load detection circuit is coupled to the HIPEF probe and is configured to compare a measured physical parameter to a corresponding threshold value. A control circuit is electrically coupled to the load detection circuit and configured to selectively disable application of pulsed energy to the at least one electrode of the HIPEF probe, based on the comparison. The measured physical parameter may include, for example, resistivity, permittivity, reflected light, pressure, or heat dissipation capability.

SEMI-AUTOMATED OPHTHALMIC PHOTOCOAGULATION METHOD AND APPARATUS

An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

MULTI-TIP PROBE USED FOR AN OCULAR PROCEDURE

An apparatus and method for denaturing corneal tissue. The apparatus includes a first electrode and a second electrode that are both inserted into a cornea. The electrodes are coupled to a power unit that delivers energy sufficient to denature corneal tissue. The dual electrode assembly allows for the creation of multiple denatured spots with a single application of energy. Additionally, the multi­electrode assembly provides uniform spacing between the denatured spots.

AN APPARATUS FOR COSMETIC TISSUE TREATMENT

A handpiece for cosmetic tissue treatment is provided, comprising an input connector for connection of a first beam-outlet end of a first optical fiber to the handpiece and for alignment of the first optical fiber with an axis of the handpiece so that a first light beam emitted from the first beam-outlet end is transmitted substantially along the axis, movable first deflecting means for deflection of the first light beam into a second light beam, and an output for emission of the second light beam towards a target surface. The handpiece may be used for ablating a thin epidermal layer of the derma of a patient and also marks on the tissue such as marks from chloasma, liver spots, red spots, tattoos, blood vessels just below the surface, etc, as well as warts, wounds, hair follicles, etc, may be ablated or treated.

Ophthalmic treatment device, system, and method of use

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Method and apparatus for generating localized hyperthermia

Ultrasound generating methods and apparatus are disclosed for producing controlled, localized hyperthermia in a selected heating zone of human tissue, utilizing at least one ultrasound transducer, preferably driven by sinusoidal excitation signals in a continuous wave or quasi-continuous wave mode to generate ultrasound. The temperature in the heated zone can be controlled by selecting the power, duration and frequency of the ultrasound. The penetration of the ultrasound, and thus the depth and volume of the target zone, can be controlled by selecting the excitation frequencies so to confine the absorption of the ultrasound beam in the target tissue. The invention is particularly useful in inducing controlled collagen shrinkage in corneal tissue to effective thermokeratoplasty (heat induced modification of the shape of the cornea).

Method of preventing capsular opacification and fibrosis utilizing an accommodative intraocular lens implant

A method of preventing capsular opacification and fibrosis utilizing an accommodative intraocular lens implant, which includes the steps of removing a cortex and nucleus of a natural lens containing a cataract from a lens capsule of an eye of a patient; applying a photosensitizer inside the lens capsule so that the photosensitizer permeates a portion of the lens capsule, the photosensitizer facilitating cross-linking of the tissue in the portion of the lens capsule; irradiating the portion of the lens capsule so as to activate cross-linkers in the tissue in the portion of the lens capsule, thereby damaging the remaining lens epithelial cells in the lens capsule with the irradiated light so as to prevent capsular opacification and fibrosis; and injecting a transparent polymer into the lens capsule of the eye in order to form an accommodative intraocular lens for replacing the cortex and nucleus of the natural lens.

Method and composition for hyperthermally treating cells

A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells.

Electrosurgical method and systems for treating glaucoma

An electrosurgical method for treating open angle and narrow angle glaucoma, comprising positioning an active electrode in close proximity to a drainage angle of the eye, the active electrode disposed on a distal end of a shaft; and applying a high frequency voltage difference between the active electrode and a return electrode sufficient to ablate and coagulate target tissue in the vicinity of the drainage angle, to create drainage canals with prolonged patency.

PDT apparatus with an addressable LED array for therapy and aiming

An apparatus for directing light to an eye for exciting a photosensitizer includes an addressable LED array so that the size and shape of the LED light used for aiming or therapy is selectable so as to match the size and shape of targeted tissue. The LED array has a configuration that provides increased LED density, increased current spreading with minimal light blocking and a simplified addressing connection sheme.

Eye therapy system

Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.

Semi-automated ophthalmic photocoagulation method and apparatus

An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

Process for dosing a chromophoric agent in a corneal tissue and apparatus for controlling the dosing

Control apparatus (1) for controlling the dosing of a chromophoric agent (100) in a corneal tissue (101), comprising: a first source (2) for irradiating the corneal tissue (101) with at least a first electromagnetic radiation (21); first measurement means (3) for measuring a first spectroscopic parameter (31), such as the fluorescence intensity or the diffused intensity; a processing unit (4) configured to calculate a factor (C) representative of the concentration of the chromophoric agent (100) inside the corneal tissue (101) in response to at least two measurements of the first spectroscopic parameter (31), of which one measurement is indicative of the energy perturbation caused by the first electromagnetic radiation (21) in the corneal tissue (101) without the chromophoric agent (100) and the further measurement is indicative of the energy perturbation caused by the first electromagnetic radiation (21) in the corneal tissue (101) containing the chromophoric agent (100).

Devices and methods for novel retinal irradiance distribution modification to improve and restore vision without producing corneal vitrification

Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.

СПОСОБ ЛЕЧЕНИЯ КЕРАТОКОНУСА ВОЗДЕЙСТВИЕМ УЛЬТРАФИОЛЕТОВОГО ИЗЛУЧЕНИЯ И УСТРОЙСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ (ВАРИАНТЫ)

Изобретение относится к области медицины, более конкретно к офтальмологии, и может быть использовано для лечения кератоконуса. Формируют в роговице одну или несколько зон облучения УФ-излучением различной формы, в том числе в виде концентрических кругов, дуг, параллельных линий, клеток, решетки, спиралей или иных геометрических фигур. В другом варианте осуществления УФ-излучение поляризуют и, направляя плоскость поляризации УФ-излучения по отношению плоскости поляризации света роговицей под углом от 1 до 180 градусов, регулируют глубину воздействия УФ-излучения. Для осуществления способа используется устройство, которое включает корпус с расположенным в нем источником УФ-излучения, соединенные с ним блок питания и управления, расположенные на одной оптической оси с источником УФ-излучения оптические фокусирующие элементы и диафрагму. Диафрагма выполнена в виде маски с чередующимися прозрачными и непрозрачными участками, имеющими форму концентрических кругов, решетки, клеток, дуг, параллельных ...

LIGHT TRAP FOR EYE EXAMINATION INSTRUMENTS

DEVICE FOR THE CORNEA/CALLOSITY SHAPING FOR CORRECTING REFRACTION ERRORS OF THE EYE

TUBULAR SCHNEIDEVORRICHTUNG

NEEDLE TO ELEKTROKAUTERISATION AND THEIR MANUFACTURING PROCESSES.

EQUIPMENT TO THE ELECTRICAL SURGERY IN LIQUID ENVIRONMENT USING PLASMA PULSES

Eye accommodation recovery

Ophthalmic uses of lasers

A radio frequency device for the treatment of glaucoma

System and method for directing light into a patient's eye

Disorders of the eye can be treated by photobiomodulation therapy according to a device designed to direct light into a patient's eye, no matter the configuration of the eye. The device, including a printed circuit board that includes an array of light delivery devices and a heat sink lens, can be placed proximal to the patient's eye. The light delivery devices can be powered to generate light. The light can be directed into the patient's eye regardless of a position of the patient's eye.

EYE SURGERY PERFORMED WITH AN ELECTROSURGICAL INSTRUMENT

Method and apparatus for thermal emulsification

Methods for enhancing accommodation of a natural lens of an eye

The accommodative properties of the natural lens of an eye, which tend to degrade with age, can be enhanced, restored, or otherwise improved using the in situ treatment techniques and methodologies provided here. One exemplary method of enhancing accommodative properties of the natural lens of an eye involves an initial step of specifying treatment areas of the natural lens. These treatment areas correspond to regions of the capsular bag or regions of the crystalline lens. The method continues by increasing stiffness of the treatment areas while all or portions of the natural lens remains in situ. This results in stiffened areas of the natural lens that enhance transfer of ciliary muscle forces to a center region of the crystalline lens.

Systems and methods for the treatment of eye conditions

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material.

METHOD AND APPARATUS FOR THERMAL EMULSIFICATION

A medical device that can emulsify tissue with a heated fluid. The device may include an active heating element that is located within an inner channel at a distal end of a cannula. The cannula is adapted to be inserted into tissue such as a cornea. The active heating element can provide heat to a fluid that flows through the inner channel. The heat can be transferred into a bolus of fluid that is periodically generated by a pump. The heated bolus is then directed onto tissue.

AN ELECTRODE FOR ASSEMBLY FOR A THERMOKERATOPLASTY SYSTEM USED TO CORRECT VISION ACCUITY

An electrode assembly that can be used to apply current to a cornea. The assembly includes a tip that is attached to a stop. The stop is pressed into an inner channel of an electrode body. The stop limits the penetration depth of the tip into a cornea.

IN-SITU ADJUSTABLE INTRAOCULAR LENS

The present disclosure provides an intralocular-lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

SYSTEMS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

USE OF ELECTROMAGNETIC RADIATION IN THE TREATMENT OF SENSORY ORGANS

A method of using and devices for delivering electromagnetic radiation of a selected wavelength for the treatment of conditions pertaining to cephalic sensory organs, in particular to treating conditions of the eye (ocular conditions) and conditions pertaining to the ear (otic conditions). The invention is in particular for the treatment of organelles associated with the acoustic and optic nerves and more particularly for the treatment of age related degeneration of such organelles. The invention also provides devices for treating ocular and otic conditions.

CAPSULARHEXIS DEVICE WITH FLEXIBLE HEATING ELEMENT HAVING AN ANGLED TRANSITIONAL NECK

Various embodiments of a capsularhexis device include a resistive-heating element comprising an electrically resistive, superelastic wire forming a loop between first and second ends of the superelastic wire. The loop may be retracted into a collapsed, retracted position or ejected into an expanded position. The first and second ends of the loop may at least partially extend at an angle from a planar face defined by the loop, to the insulating portion, to form a transitional neck between the loop and the insulating portion. The transitional neck may have a gap between the first and second ends at the insulating portion that is wider than a gap between the first and second ends on the opposing side of the transitional neck. The gap in the loop of superelastic wire may be sufficiently small to allow the loop to form a continuous cut in a capsule of an eye.

EYE ACCOMMODATION RECOVERY

A method for eye accommodation recovery comprises transscleral pulse infrared laser radiation treating ciliary muscle and using visible light for fixing sight direction, wherein in one alternative of the method color of light used for fixing the sight direction and treating eye retina is altered, hence, controlling the state of the accommodation apparatus of the eye, and pulse infrared laser radiation intensity treating ciliary muscle is changed simultaneously. Another alternative of the method comprises dispersion of visible light in the vicinity of the eye pupil providing dispersed light effect on a greater area of eye retina. Color of visible light is altered simultaneously, hence, controlling the state of the accommodation apparatus of the eye.

METHOD AND APPARATUS FOR MODIFICATIONS OF VISUAL ACUITY BY THERMAL MEANS

This invention is a thermo-keratoplasty system and method for locally heatin g and reshaping a cornea in a manner that produces a minimal regression of the corneal correction. The system includes a probe (1 2) that is coupled to a power source which can provide current at a predetermined power, frequency and time duration. The probe (12) has a sharp tip (36) that is inserted into the stroma of the cornea (48). The tip has an insulated stop that controls the depth of tip penetration. Current flows into the cornea through the probe tip to locally heat and denature the corneal tissue. The denatured tissue causes a subseque nt shrinkage of the cornea. A pattern of denatured areas can be created around the cornea to correct the vision of the eye.

Capsulotomy repair device and method for capsulotomy repair

Device for the macular degeneration treatment

The present concerns ophthalmology. This invention can be used for the treatment of retina degeneration diseases, particularly for macular degeneration treatment. A method of the macula degeneration treatment by irradiating of the retina damaged areas through the pupil wherein the technique of the irradiation performed by the quasi-monochromatic light pulse in visible and near infra-red spectral range with energy that does not exceed 10<-5> joules. A device for the macula degeneration treatment that consists of radiation source, radiation directional pattern forming means, means to deliver the radiation to the given part of the retina through the pupil, power supply unit, and indicator and control unit; the device comprising at least one light emitting diode (LED) is used as the source of radiation.

DEVICE TO PREVENT the TRANSMISSION OF LIGHT FOR APPARATUSES Of EXAMINATION OR TREATMENT OF the EYES

EYE THERAPY SYSTEM

Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

ACTIVE RETINAL IMPLANT

The invention relates to an active retinal implant (10) to be implanted into an eye, with an array (16) of stimulation elements (17) that emit stimulation signals to cells of the retina, wherein the stimulation elements (17) are designed as radiation-emitting elements.

PHOTOCHEMICAL TISSUE BONDING

Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair.

ELECTRICALLY-INDUCED THERMOKERATOPLASTY SYSTEMS AND METHOD

Applicators for performing electrically-induced thermokeratoplasty including two electrical conducting elements (306, 308) coaxially disposed relative to one another and separated by an electrically insulating element (310) having a selected thickness. At least a portion of each conducting tube is coated with an electrically insulating and thermally conductive material (318), e.g., anodized aluminium, so as to electrically insulate the conducting tubes from corneal tissue upon placement of the applicator on a subjet’s cornea while facilitating extraction of heat from the cornea. A cooling (342, 312, 314, 316) device may be thermally coupled to said insulating element for cooling thereof. They may comprise a vacuum source (340) and passages (336, 338) for applying suction to the corneal tissue. Sensors and a feedback circuit may be provided to determine when a treatment modality has archieved an intended effect.

METHODS AND DEVICES FOR CROSSLINKING OF CORNEAL COLLAGEN AND FOR TREATMENT OF DISORDERS OF THE EYE

Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

RF ABLATION AND ULTRASOUND CATHETER FOR CROSSING CHRONIC TOTAL OCCLUSIONS

A combination catheter includes an ultrasound transducer and RF ablation electrode. The ultrasound transducer transmits ultrasound signals into and receives echo signals from a vessel. The echo signals are processed and used to produce an image of the tissue surrounding the catheter. A driveshaft rotates the ultrasound transducer to obtain a 360° view of the vessel wall. At the distal end of the driveshaft is an electrode. An RF generator is electrically coupled to the driveshaft to deliver RF energy to the electrode at the distal end of the driveshaft to ablate occluding material in the vessel. The electrode may have a variety of tip shapes including concave, roughened, or expandable configurations, depending on the size of the vessel and composition of the occluding material to be ablated. Alternatively, the RF ablation energy may be delivered to a guidewire that is used to route the ultrasound catheter through a patient's vasculature. Finally, a steerable catheter can be used to further ...

LIGHT ADJUSTABLE INTRAOCULAR LENS WITH A MODULABLE ABSORPTION FRONT PROTECTION LAYER

Embodiments of a modulable absorption light adjustable lens (MALAL) comprise a light adjustable lens that is capable of changing its optical properties upon an adjusting irradiation, including a photo-modifiable material; and a modulable absorption front protection layer, including a modulable absorption compound whose absorption properties can be modulated with a modulating stimulus. Other embodiments include a method of adjusting an optical property of a modulable absorption light adjustable lens, the method comprising: reducing an absorption of a modulable absorption compound of a modulable absorption front protection layer of the MALAL by a modulating stimulus, the MALAL having been previously implanted into an eye; and changing an optical property of a light adjustable lens of the MALAL by applying an adjusting irradiation.

Ophthalmic phototherapy device and associated treatment method

An ophthalmic phototherapy device and associated phototherapy treatment method for promoting healing of damaged or diseased eye tissue. The ophthalmic phototherapy device includes a light emitting mechanism for transmitting light of at least one preselected wavelength to the eye tissue. The ophthalmic phototherapy method includes directing light of at least one wavelength for a selected period of time to a portion of damaged or diseased eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates cellular activity in the eye tissue to promote healing.

Thermokeratoplasty system with a power supply that can determine a wet or dry cornea

A power supply for a thermokeratoplasty system. The power supply can be connected to an electrode and a return element that are both coupled to a cornea. The power supply can perform a test routine to determine whether the cornea is too “wet” or too “dry”.

Corneal denervation for treatment of ocular pain

Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment.

Neurological prosthesis

A method improving or restoring neural function in a mammalian subject in need thereof, the method including: using an input receiver to record an input signal generated by a first set of nerve cells; using an encoder unit including a set of encoders to generate a set of coded outputs in response to the input signal; using the encoded outputs to drive an output generator; and using an output generator to activate a second set of nerve cells wherein the second set of nerve cells is separated from the first set of nerve cells by impaired set of signaling cells. In some embodiments, the second set of nerve cells produces a response that is substantially the same as the response in an unimpaired subject.

Coaxial bipolar probe

Improves bipolar electrode probe devices for use in electrocautery and electrocoagulation include a central electrode having an outer electrode coaxially disposed therearound. The central and outer electrodes are electrically insulated from each other and are adapted to receive a high frequency voltage or direct voltage thereacross. The diameter of the central electrode as well as the inner and outer diameters of the outer electrode are dimensioned in accordance with the designated use of the probe, for example: general surgery, specialty surgery or microsurgery. In one of the improved embodiments, the central or axial electrode has an elongate untapered cylindrical shape having an exposed flat transverse surface at one end thereof. The outer electrode has an elongate hollow tubular shape which is coaxially disposed around the central electrode. A first end of the outer electrode is disposed behind the tip of the central electrode in order to form a probe end wherein the central electrode ...

Medical instrument, and method of utilizing same

A medical instrument including a cautery portion for use in performing an anterior capsulotomy during extracapsular cataract extraction surgery. A substantially rigid stem portion is connected between the cautery portion and a handle portion, and is provided with bends to facilitate maneuverability of the cautery portion and to avoid substantial interference with the surgical field of vision by the handle portion. An electrical path is defined through the handle portion and stem portion to the cautery portion so as to permit electrical current to be supplied to the cautery portion so as to rapidly heat same to a burning temperature so as to burn a circle in the anterior lens capsule of the eye during surgery. The stem portion and handle portion are covered with an electrically-insulative material.

Method and apparatus for modifications of visual acuity by thermal means

A thermokeratoplasty system and method for locally heating and reshaping a cornea in a manner that produces a minimal regression of the corneal correction. The system includes a probe that is coupled to a power source which can provide a predetermined power, frequency and time duration that creates a thermal profile within the cornea which extends from the epithelium into the corneal stroma. The electrical return of the probe is a lid speculum which maintains the eye lids in an open position. The probe is placed into contact with the cornea and energy is transferred from the power source to the eye, through the lid speculum and back to the power source. The energy from the power supply is focused by a probe tip that locally heats and denatures the cornea, and causes a subsequent shrinkage of corneal tissue. A pattern of denatured areas can be created around the cornea to correct the vision of the eye. It has been found that power no greater than 1.2 watts, for a duration no greater than ...

METHOD AND APPARATUS FOR TREATMENT OF OCULAR TISSUE USING COMBINED MODALITIES

A method is provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as pen-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that enables cross-linking (CXL) therapy to be combined with thermal therapy. 116-. (canceled)17. A method of treating ocular tissue-comprising:directing one or more beams at an ocular tissue, the one or more beams comprising a laser radiation and an optical coherence tomography (OCT) light,wherein the laser thermal radiation modifies the ocular tissue shrinks the ocular tissue to open an adjacent drainage channel of the eye to reduce intraocular pressure,wherein the OCT light provides images of a modification of the ocular tissue; andadjusting parameters of the treatment of the ocular tissue based on the OCT images.18. (canceled)19. The method of claim 17 , wherein the drainage channel comprises a Schlemm's canal.20. The method of claim 17 , wherein the drainage channel comprises a plurality of drainage channels.21. The method of claim 17 , wherein a degree of opacification and a depth and a size of a lesion at each location over which the laser radiation has deposited laser energy is sampled by the OCT light for customizing a next exposure pattern of the treatment.22. The method of claim 17 , wherein the one or more beams comprises a coaxial beam comprising the laser radiation and the OCT light.23. The method of claim 17 , wherein ...

Eye therapy system

A system includes a conducting element that conducts energy from an energy source to apply therapy to an eye. The system includes a covering configured to be removably attached to the conducting element. The covering has an interface surface that is positionable at an eye. At least a portion of the interface surface includes one or more dielectric materials. Energy is deliverable to the eye through the interface surface. In one aspect, the covering provides an electrical insulator to minimize the concentration of electrical current in the area of contact with the eye. In another aspect, the covering allows the eye to be cooled during the application of energy without directly applying coolant to the eye. In another aspect, the covering includes a dielectric layer that may provide varying impedances that allow different patterns for energy delivery. In another aspect, the sheath promotes hygienic use of the conducting element.

APPARATUS FOR THE CROSS-LINKING OF OCULAR TISSUE WITH ELECTROMAGNETIC RADIATION

An apparatus for generating an alteration of biomechanical properties of ocular tissue, into which a photosensitiser (14) has been introduced, contains means (18, 20) for radiating into the tissue electromagnetic radiation (12) which reacts with the photosensitiser for the purpose of generating a cross-linking. The setting means permit an inhomogeneous distribution of the irradiance in the tissue and a setting of the depth of action (16).

Methods to regulate polarization and enhance function of excitable cells

Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells.

Photochemical tissue bonding

Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.

PHOTOKINETIC OCULAR DRUG DELIVERY METHODS AND APPARATUS

APPARATUS FOR TREATMENT OF PRESBYOPIA AND OTHER EYE DISORDERS USING FIBER-COUPLED-LASERS

DEVICE, SYSTEM, AND METHOD FOR EPITHELIUM PROTECTION DURING CORNEA RESHAPING

УСТРОЙСТВО ДЛЯ АККОМОДАЦИИ ХРУСТАЛИКА

Электрод для электростимуляции зрительного нерва и зрительных путей и контроля физиологических параметров орбитальных структур глаза, способ его использования и устройство для электростимуляции

Группа изобретений относится к области медицины, а именно к офтальмологии, неврологии, нейрохирургии, челюстно-лицевой хирургии, физиотерапии, и может быть использована для лечения заболеваний и дистрофических процессов в зрительных путях, глазном яблоке и зрительном нерве. Электрод для электростимуляции зрительного нерва и зрительных путей и контроля физиологических параметров орбитальных структур включает полимерную основу, выполненную с возможностью ее размещения вдоль нижней стенки орбиты от переднего орбитального края до вершины орбиты. В основе расположены контакты для передачи электрических стимулирующих сигналов на глазное яблоко, зрительный нерв, зрительные пути и/или снятия физиологических параметров. Контакты подключены к блоку управления электрогенератора и объединены в две группы. Одна группа расположена ближе к дистальному концу полимерной основы и выполнена с возможностью преимущественного воздействия на зрительный нерв и зрительные пути. Другая группа расположена ближе к ...

Surgical needle holder

Ophthalmic uses of lasers

ELECTROCAUTERY NEEDLE AND METHOD OF FORMING IT

DEVICE FOR COSMETIC FABRIC TREATMENT

CHANGES OF VISUAL ACUITY BY THERMAL MEANS

PHOTOCHEMICAL FABRIC CONNECTION

ELECTRICAL-INDUCED THERMOKERATOPLASTI SYSTEM

Method and apparatus for the treatment of strabismus

Semi-automated ophthalmic photocoagulation method and apparatus

Aberration control by corneal collagen crosslinking combined with beam-shaping technique

Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A scanning laser or the like is used to perform the corneal collagen crosslinking by locally altering the optical path length (thickness, refractive index, or both).

Tubular cutter device and methods for cutting and removing strips of tissue from the body of a patient

Methods and devices for cutting strips of tissue from masses of tissue inside or outside of the bodies of human or animal subjects. The device generally comprises a) an elongate cutting tube that has a distal end and a lumen that opens through an opening in the distal end and b) first and second cutting edges formed on generally opposite edges of the distal end of the cutting tube and separated by a distance D. The device is advanced through tissue to cut a strip of tissue of approximate width W. Width W is approximately equal to distance D.

Corneal treatment system and method

A system for bilateral or monocular photochemical cross-linking of corneal collagen employs selectable light in a selected wavelength band as the excitation source and riboflavin as the photosensitizer. The system has an illumination source which may have multi-spectral capability, light guides for delivery of light to the optical head for projection onto the corneal surface, selectable radiation patterns to accommodate individual corneal architecture, and red light phototherapy to limit apoptosis and accelerate healing time. Aiming beams provide alignment of the optical head to the patient cornea. A microprocessor-controlled rotary solenoid mechanical shutter provides discontinuous illumination for tissue reoxygenation, and devices and methods may be included for the in situ determination of oxygen utilization and the riboflavin content of the cornea.

Photochemical tissue bonding

Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair.

APPLICATION OF ENERGY IN MEDICAL TREATMENTS

Embodiments apply light energy in medical treatments. To enhance or control the effect of the light energy, embodiments apply the light energy after tissue has been treated, e.g., with a photosensitizing agent. For example, embodiments may treat target tissue with riboflavin before exposure to ultraviolet light. For example, a system for cataract surgery includes a removal system configured to remove a first lens from an eye, wherein a capsular bag remains in the eye after removal of the first lens. The system includes an application system configured to treat lenticular epithelial cells in the capsular bag with the photosensitizing agent. The system includes a delivery system with a light source and an optical device. The optical device delivers light to the treated lenticular epithelial cells. Energy from the light destroys the lenticular epithelial cells in the capsular bag to reduce the growth of epithelial cells that cause posterior capsule opacification. 1. A method for cataract surgery , comprising:removing a first lens from an eye, wherein a capsular bag remains in the eye after removal of the first lens;treating lenticular epithelial cells in the capsular bag with a photosensitizing agent;delivering light to the treated lenticular epithelial cells, wherein energy from the light destroys the lenticular epithelial cells in the capsular bag to reduce the growth of epithelial cells that cause posterior capsule opacification after cataract surgery; andimplanting a second lens in the capsular bag to replace the removed first lens,2. The method of claim 1 , wherein the light is ultraviolet (UV) light and the photosensitizing agent is riboflavin.3. The method of claim 1 , wherein delivering the light to the lenticular epithelial cells includes delivering the light according to multiphoton excitation.4. The method of claim 1 , wherein delivering the light to the lenticular epithelial cells includes delivering the light via an optical device positioned external to ...

SYSTEM AND METHOD FOR TREATING AN EYE

The invention provides a device for delivering electromagnetic radiation to a limbal area of an eye that transforms one or more beams of electromagnetic radiation that are incident on a first side into one or more emitted beams of the electromagnetic radiation where the one or more beams are arrayed in a cylindrical array, an array of one or more beams each beam having a cross sectional shape of a circular arc or an array comprising a beam having an annular cross section. The invention also provides a system for delivering electromagnetic radiation to the limbal area of an eye that includes one or more devices of the invention and a source of electromagnetic radiation. The system may be used in the treatment of glaucoma. 127-. (canceled)28. A system for delivering electromagnetic radiation to a region of an eye , the system comprising:(a) at least one source of electromagnetic radiation configured for producing a treatment beam of a first electromagnetic radiation and a second aiming beam of a second electromagnetic radiation of a visual spectral range;at least one device configured for directing therethrough the first and second beams of the first and second electromagnetic radiations from said at least one source of electromagnetic radiation to one or more regions of an eye, said at least one device being configured in accordance with a circumference of a limbus or a sclera around the limbus and being manipulatable for directing the aiming visible beam onto said circumference thereby enabling visible control of the treatment beam propagation through said device to the one or more regions on said circumference,each of said at least one devices having a first side and a second side, and transforming each of the treatment and aiming beams from the first and second sources that are incident on the first side of the device into one or more beams of the respective electromagnetic radiation propagating from the second side.29. The system according to claim 28 , wherein ...

BIOTRANSDUCER FOR TREATING MACULAR DEGENERATION AND OTHER CONDITIONS AND RELATED SYSTEM AND METHOD

A system includes a resonant circuit having an inductor coupled to a piezoelectric oscillator. The system also includes one or more light emitting diodes (LEDs) configured to generate illumination based on an output of the resonant circuit. The system further includes a frequency generator configured to frequency modulate the output of the resonant circuit. In addition, the system includes a power supply configured to provide a voltage to the resonant circuit and activate a piezoelectric effect in the piezoelectric oscillator. The piezoelectric oscillator may include a piezoelectric material that is configured to undergo electrical distortion in response to an applied voltage from the power supply. The frequency generator can be configured to alter a capacitance and/or an inductance of the resonant circuit. The illumination can be applied to the retina or other tissue of a body to adjust a pH of cells in the tissue. 1. An apparatus comprising:a resonant circuit comprising an inductor coupled to a piezoelectric oscillator;one or more light emitting diodes (LEDs) configured to generate illumination based on an output of the resonant circuit; anda frequency generator configured to frequency modulate the output of the resonant circuit.2. The apparatus of claim 1 , wherein the piezoelectric oscillator comprises a piezoelectric material that is configured to undergo electrical distortion in response to an applied voltage.3. The apparatus of claim 2 , wherein the piezoelectric material is configured to temporarily create a pulsing energy field.4. The apparatus of claim 1 , wherein the frequency generator is configured to frequency modulate the output of the resonant circuit by altering at least one of a capacitance and an inductance of the resonant circuit.5. The apparatus of claim 1 , wherein the one or more LEDs are configured to at least one of:generate the illumination at one or more desired frequencies; andgenerate the illumination in one or more desired wavelength ...

Eye Therapy System

Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O 2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O 2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O 2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.

Eye Therapy System

Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

CORNEAL DENERVATION FOR TREATMENT OF OCULAR PAIN

Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment. 1. A method of treating a cornea of an eye , comprising:applying an apparatus to an anterior surface of a cornea, wherein the cornea comprises an epithelium, a stroma, an inner portion and an outer portion; andapplying energy from the apparatus to denervate a region of the cornea corresponding to a denervation treatment profile.2. The method of claim 1 , wherein treating comprises denervating a portion of the cornea.3. The method of claim 1 , wherein treating comprises denervating an inner portion of the cornea.4. The method of claim 1 , wherein the apparatus comprises an annular ring configured to contact the cornea.5. The method of claim 1 , wherein the energy comprises radiofrequency energy claim 1 , heating claim 1 , cooling claim 1 , light claim 1 , or ultrasound.6. The method of claim 1 , wherein applying energy comprises applying energy to the outer portion according to the denervation treatment profile.7. The method of claim 1 , wherein denervating comprises severing axons in the region of the cornea.8. The method of claim 1 , wherein denervation comprises stunning corneal nerves claim 1 , increasing the threshold of the corneal nerves claim 1 , inhibiting corneal nerve transmission claim 1 , ...

LIGHT THERAPY FOR EYELASH GROWTH

Systems, methods, and devices for promoting eyelash hair growth includes an energy transducer, positionable proximate the eyelid, configured to provide light energy to a user's eyelids at an output wavelength suitable for stimulating eyelash hair growth, and a scleral shield, positionable inside of the eyelid, to protect the eye from the light energy. The device may be powered by an internal power source, such as a rechargeable battery or disposable batteries, or by an external power source, such as a plug used in connection with an AC outlet. In use, the eyelid is positioned between the energy transducer and the scleral shield, and the light energy from the energy transducer is applied to the eyelash region of the eyelid to promote eyelash hair growth. 1. A light therapy device for stimulating and/or promoting eyelash growth , comprising:an energy transducer configured to provide light energy at one or more wavelengths to an eyelash region of an eyelid; anda scleral shield configured to block light energy toward the eyeball;wherein when the eyelid is positioned between the energy transducer and the scleral shield, the energy transducer provides light energy at a first wavelength to the eyelash region suitable for stimulating and/or promoting eyelash hair growth, and the scleral shield blocks and/or protects the eyeball from the light energy.2. The device of wherein the first wavelength for eyelash hair growth is within a wavelength range of 450 nm-700 nm.3. The device of claim 1 , wherein the energy transducer is further configured to provide light energy at a second wavelength to treat bacteria on the eyelid.4. The device of wherein the second wavelength is within a wavelength range of 400 nm-450 nm.5. The device of claim 1 , wherein the energy transducer is further configured to provide light energy at a third wavelength to heat the eyelid and soften or melt meibum within meibomian glands.6. The device of wherein the third wavelength is within a wavelength range ...

Systems and Methods For the Treatment of Eye Conditions

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region. 1. A device for treating a mammalian eye having an eyelid , comprising:a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of or coated with an energy-absorbing material activated by a light energy;an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy to the energy absorbing material at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material; andwherein when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer heats the energy-absorbing material of the scleral shield which conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.2. The device of claim 1 , wherein the energy transducer is further configured to provide light energy at a second wavelength selected to heat an outer surface of the eyelid.3. The device of claim 1 , ...

UV RADIATION DEVICES AND METHODS OF USE THEREOF

The present invention features devices, systems, and methods of use thereof for delivering therapeutic or sterilizing ultraviolet (UV) radiation, such as UVC or UVA radiation. 1. A therapeutic device comprising a base component and a head component , the head component comprising a distal portion and a proximal portion , the distal portion of the head component configured to contact an eyelid of a subject , and the proximal portion of the head component configured to be attached to the base component;wherein the distal portion of the head component is configured to deliver a therapeutic dose of energy from a plurality of energy sources comprising a source of ultraviolet C (UVC) radiation, a source of infrared (IR) radiation, and a source of ultrasound;wherein the plurality of energy sources is configured to deliver the therapeutic dose of energy to the eyelid of the subject at a predetermined power when the distal portion of the head component contacts the eyelid.2. The device of claim 1 , wherein:{'sup': 2', '2, 'a) the UVC radiation has a wavelength of from about 100 nm to about 280 nm or a radiation intensity of from about 20 mW/cmto about 1,000 mW/cm;'}{'sup': 2', '2, 'b) the IR radiation has a peak wavelength of from about 750 nm to about 1,000,000 nm or a radiation intensity of from about 20 mW/cmto about 1,000 mW/cm; or'}c) the ultrasound has a frequency of from about 1 MHz to about 10 MHz.36-. (canceled)7. The device of claim 1 , further comprising:(a) a temperature sensor and/or a source of heat;(b) a source of microwave radiation and/or a source of intense pulsed light; or(c) a contact sensor.89-. (canceled)10. A therapeutic device comprising a base component and a head component claim 1 , the head component comprising a distal portion and a proximal portion claim 1 , the distal portion of the head component is configured to deliver a therapeutic dose of UVC or ultraviolet A (UVA) radiation to an eye of a subject from a source of UVC or UVA radiation claim ...

OPHTHALMIC TREATMENT DEVICE, SYSTEM, AND METHOD OF USE

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking. 1. An ophthalmic treatment system , comprising:a light source device comprising at least one light source;at least one optical treatment head operatively coupled to the light source device, and configured to provide at least one treatment light;at least one processor associated with the light source device and programmed to control operation of the light source device to provide a discontinuous treatment light projection onto a patient's eye for a selected treatment time comprising successive treatment light exposure periods of a first light intensity level separated by non-treatment periods at a second light intensity level lower than the first light intensity level; andwherein the at least one optical treatment head projects the treatment light at least two inches to the patient's eye such that a position of the at least one optical treatment head relative to the patient's eye allows physician visualization and accessibility to the patient's eye during treatment.2. The ophthalmic treatment system of claim 1 , wherein the at least one optical treatment head projects the treatment light at least three inches to the patient's eye.3. The ophthalmic treatment system of claim 1 , wherein the at least one optical treatment head projects the ...

OPHTHALMIC TREATMENT DEVICE, SYSTEM, AND METHOD OF USE

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking. 1. An ophthalmic treatment system , comprising:a light source device comprising at least one light source;at least one optical treatment head operatively coupled to the light source device, and configured to provide at least one treatment light;at least one processor associated with the light source device and programmed to control operation of the light source device to provide a discontinuous treatment light projection onto a patient's eye for a selected treatment time comprising successive treatment light exposure periods of a first light intensity level separated by non-treatment periods at a second light intensity level lower than the first light intensity level; andwherein each treatment light exposure period and non-treatment period of the discontinuous treatment light projection is in the range from 5 seconds to 25 seconds.2. The ophthalmic treatment system of claim 1 , wherein the at least one optical treatment head projects the treatment light at least two inches to the patient's eye.3. The ophthalmic treatment system of claim 1 , wherein the at least one optical treatment head projects the treatment light between three to six inches to the patient's eye.4. The ophthalmic treatment system of claim 1 , wherein the treatment light ...

Method of altering the refractive properties of an eye

The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.

OPHTHALMIC TREATMENT APPARATUS AND BEAM CONTROL METHOD THEREFOR

The present invention relates to an ophthalmic treatment apparatus and to a beam control method therefor. The ophthalmic treatment apparatus according to the present invention comprises: a beam generating unit for generating beams having different pulse energies; a bubble sensing unit for sensing whether or not bubbles have been generated, as well as the amount of generated bubbles, on the basis of the pulse energy of the beam generated by the beam generating unit and radiated onto the treatment region of an eyeball; and a control unit for controlling the operation of the beam generating unit such that the pulse energy of the beam generated by the beam generating unit can be adjusted in accordance with the signal from the bubble sensing unit. 1a beam generation unit which generates beams having different types of pulse energy;a bubble detection unit which detects whether a bubble is generated or an amount of bubbles generated by the pulse energy of the beams generated by the beam generation unit and radiated to a treatment region of an eyeball; anda control unit which controls an operation of the beam generation unit based on a signal from the bubble detection unit so that the pulse energy of the beams generated by the beam generation unit is controlled.. An ophthalmic treatment apparatus, comprising: This application is a continuation of U.S. patent application Ser. No. 14/414,696, filed Jan. 13, 2015, now U.S. Pat. No. 10,080,683 issued Sep. 25, 2018, which is a U.S. National Stage Application of PCT/KR2013/006331 filed Jul. 15, 2013, which claims priority to Korean Patent Application 10-2012-0076779 filed Jul. 13, 2012, which are hereby incorporated by reference in their entirety.The present invention relates to an ophthalmic treatment apparatus and a method of controlling, by the ophthalmic treatment apparatus, beams and, more particularly, to an ophthalmic treatment apparatus for measuring pulse energy of a beam for treatment that is radiated to the treatment ...

Compounds and Compositions for Eye Treatments

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that that generates cross-linking in the cornea in response to exposure to an electromagnetic irradiation. This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which in which abnormal shaping of the cornea (e.g., thinning of the cornea, e.g., bilateral thinning of the cornea, e.g., bilateral thinning of the central, paracentral, or peripheral cornea; or steepening (e.g., bulging) of the cornea) contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) corneal ectatic disorders; (ii) vision conditions; and (iii) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include keratoconus, keratoglobus, pellucid marginal degeneration, corneal ectasia (e.g., post-operative ectasia, e.g., post-LASIK ectasia), Terrien's marginal degeneration, myopia, hyperopia, astigmatism, irregular astigmatism, and presbyopia. 3. The compound of any one of - , wherein each of IV , R , and Ris independently selected from H and C(O)R.4. The compound of any one of - , wherein each occurrence of Ris independently Calkyl , optionally substituted with from 1-6 independently selected R(e.g. , Cor Calkyl , optionally substituted with from 1-6 independently selected R; e.g. , Cor Cor Cunsubstituted alkyl (e.g. , CH)).5. The compound of any one of - , wherein each of IV , R , and Ris independently selected from H and C(O)Me (e.g. , R , R , and Rare each H; or R , R , and Rare each C(O)Me).6. The compound of ...

DEVICES AND METHODS FOR TARGETED DELIVERY OF A SUBSTANCE

A device for applying a bubble of a substance to a tissue surface, the device comprising a cannula, a distal tip at the distal end portion of the cannula, the distal tip having a bubble support surface and an exit port extending through the bubble support surface, an expansion fluid passageway extending through the cannula to the exit port, a source of an expansion fluid and an actuator therefor. In some arrangements, the distal tip can be configured to support a layer of the substance thereon over the distal port and the device can be configured such that the advancement of the expansion fluid from the fluid source through the exit port causes at least one bubble of the substance to form on the distal tip, wherein the at least a portion of the bubble can be transferred to the tissue surface to treat a defect on the tissue surface. 1. A device for applying a bubble of a substance to a tissue surface , the device comprising:a cannula comprising a proximal end portion, a distal end portion, and an intermediate portion extending therebetween;a distal tip at the distal end portion of the cannula, the distal tip having a bubble support surface and an exit port extending through the bubble support surface;an expansion fluid passageway extending through at least the intermediate portion and the distal portion of the cannula, the expansion fluid passageway being in fluid communication with the exit port;a source of an expansion fluid; andan actuator coupled with the source of the expansion fluid and configured to selectively advance the expansion fluid through the expansion fluid passageway and the exit port upon actuation of the actuator; in an operable state, the distal tip is configured to support a layer of the substance on the bubble support surface so that the layer of the substance completely covers the distal port;', 'when the device is in the operable state, the device is configured such that the advancement of the expansion fluid from the fluid source through the ...

OPHTHALMOLOGICAL DEVICE AND METHOD FOR THE TREATMENT OF CORNEAL DISEASES

An ophthalmological device () for the treatment of corneal diseases such as keratoconus and glaucoma, comprises a moulding head (), a suction body () and a UV lamp (). The moulding head () has a hollow cylindrical configuration and includes a rigid moulding lens () for shaping the cornea of an eye () of a patient. The lens is curved and defines a plurality of apertures therein. The suction body () has a hollow cylindrical configuration. The lamp () is fitted to the suction body. Moulding head () and suction body () together define a chamber () from which air is evacuated so as to induce a partial vacuum within the chamber () for attracting the cornea onto the lens (). A photo-sensitizer is applied to the eye and while the cornea is held against the mould, it is irradiated with UV light by lamp () so as to cross-link collagen fibres in the cornea. 1. An ophthalmological device for the treatment of corneal diseases , which includes:a mould having a curved, transparent moulding surface defining a plurality of apertures therein, which is applied to the coma of an eye of a patient for shaping the corneal tissue to a desired curvature;a suction body defining a suction chamber in which a partial vacuum is induced so as to form a partial vacuum within the mould which attracts the cornea onto the moulding surface; anda radiation source for irradiating the cornea with a beam of radiation.2. The ophthalmological device as claimed in claim 1 , wherein the mould includes a rigid lens winch defines said curved moulding surface claim 1 , the moulding surface of the lens having a predetermined curvature so as to shape the corneal tissue to said desired curvature.3. The ophthalmological device as claimed in claim 2 , wherein the mould lens is in the form of a rigid contact lens.4. The ophthalmological device as claimed in claim 3 , wherein the mould is removably connected to the suction body claim 3 , thereby permitting the mould to be removed and replaced by another mould with a ...

Devices and Methods for Novel Retinal Irradiance Distribution Modification to Improve and Restore Vision without Producing Corneal Vitrification

Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.

Using intense pulsed light to lighten eye color

The present invention relates to a device for permanently changing the color of the iris, such as from brown to blue. The invention is a system that includes a slit lamp microscope, a source of intense pulsed light (IPL), optical tracking and measuring systems, and a device that prevents the application of light to the pupil. The IPL provides a simultaneous application of a range of wavelengths, rather than the single wavelength typically applied by lasers. In a preferred embodiment, the IPL is applied as annular ring, striking only the iris and not the pupil or the sclera. Air or liquid cooling can be used to prevent the eye from overheating.

Systems and methods for photoactivating a photosensitizer applied to an eye

An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

Light therapy platform enhanced controller

Disclosed is a therapeutic lamp platform controller. According to an exemplary embodiment of this disclosure, provided is a controller comprising a power source; a control circuit operatively connected to the power source, the control circuit including one or more outputs to drive a plurality of radiant lamps associated with a therapeutic lamp platform, the plurality of radiant lamps including a mixed combination of different wavelength radiant energy and the plurality of radiant lamps disposed to communicate the radiant energy to a user treatment area; a user display operatively connected to the control circuit; and a user control switch operatively connected to the control circuit, wherein the control circuit is configured to control a dosage amount of radiant energy communicated to the user treatment area.

MINIMALLY INVASIVE GLAUCOMA SURGICAL INSTRUMENT AND METHOD

Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal. 1. A device useable for removing trabecular meshwork tissue from the eye of a subject , said device comprising:an elongate probe comprising a probe shaft having a distal end, a hollow inner chamber and an opening near its distal end;a movable cutter disposed within the hollow inner chamber; anda protective member extending at an angle from the distal end of the probe shaft, said protective member having a tip, an upper side and a lower side, the opening being located adjacent to the upper side of the protective member;the probe shaft being insertable into the anterior chamber of the eye and the distal tip of the protective member being thereafter advanceable through the trabecular meshwork thereby positioning the protective member in Schlemm's canal with an opposing wall of Schlemm's canal juxtaposed to the lower side of the protective member and trabecular meshwork tissue juxtaposed to the upper side of the protective member; andthe moveable cutter being operable to sever trabecular meshwork tissue that passes through the opening.2. A device according to wherein the protective member is advanceable through Schlemm's canal causing trabecular meshwork tissue to pass through the opening.3. A device according to further comprising an aspiration lumen useable for aspirating trabecular meshwork tissue through the opening.4. A device according to further comprising an aspiration pump that is attachable to the aspiration lumen.5. A device according to wherein the moveable cutter rotates.6. A device according to wherein the moveable cutter comprises a rotating ...

Real Time Acoustic Dosimetry For Corneal Collagen Crosslinking

A change in the response of the cornea to ultrasonic energy directed into the cornea is monitored during irradiation of the cornea to bring about corneal crosslinking. Because the change in ultrasonic response is correlated with the degree of crosslinking achieved, a desired degree of crosslinking can be achieved by terminating the irradiation when the change reaches a threshold. The change in ultrasonic response can be determined by taking a baseline measurement before irradiation and additional measurements during irradiation using the same ultrasonic transducer (). The transducers may be carried on a device () resembling a contact lens which overlies the eye and which transmits the light used in the irradiation step to the eye. 1. A device for applying irradiation and ultrasound to an eye of a subject comprising:(a) a housing having an inwardly-facing surface adapted to rest on an anterior surface of the eye;(b) an optical diffuser mounted to the housing, the diffuser having inner and outer surfaces facing inwardly and outwardly; and(c) a ultrasonic transducer mounted to the housing and disposed outward of the diffuser so that the diffuser is disposed between the transducer and the eye when the housing rests on the anterior surface of the eye.2. A device as claimed in wherein the ultrasonic transducer is coaxial with the diffuser.3. A device as claimed in wherein the housing includes a peripheral portion facing inwardly claim 1 , the peripheral portion defining the inner surface of the housing and claim 1 , the inner surface being adapted to bear on the sclera of the eye and maintain the diffuser and the transducer in alignment with the cornea.4. A device as claimed in wherein the peripheral portion is adapted to maintain a space between the diffuser and the cornea. The present application is a continuation application of U.S. patent application Ser. No. 15/856,651, filed Dec. 28, 2017, which is a divisional application of U.S. patent application Ser. No. 14/751, ...

Systems, Methods, and Compositions For Cross-Linking Treatments of an Eye

Systems, methods, and compositions generate cross-linking activity for treatment of eye disorders. Various agents, additives, buffers, etc., may be employed in formulations with a cross-linking agent to enhance treatment. For example, a composition for applying treatment to a cornea of an eye includes a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light. The composition also includes an iron additive and citrate buffer. In some cases, the cross-linking agent may include riboflavin. In other cases, the iron additive may include FeSO. In further cases, the iron additive may be dissolved in the citrate buffer. 1. A system for applying treatment to a cornea of an eye , comprising: a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light, the cross-linking agent including at least 0.1% riboflavin;', 'at least 0.25 mM of an iron additive; and', 'citrate buffer;, 'a composition includinga light source configured to emit the photo-activating light;one or more optical elements configured to direct the photo-activating light from the light source to an area of the cornea; anda controller configured to control at least one of the light source or the one or more optical elements to deliver a dose of the photo-activating light to the area of the cornea to generate cross-linking activity based on an application of the composition to the cornea.2. The system of claim 1 , wherein the iron additive is FeSO.3. The system of claim 1 , wherein the iron additive is dissolved in the citrate buffer.4. The system of claim 1 , wherein the photo-activating light is ultraviolet light.5. The system of claim 1 , wherein the composition contains between 0.1% and 0.5% riboflavin.6. The system of claim 1 , wherein the composition contains at least 0.5 mM of the iron additive.7. The system of claim 1 , wherein the composition contains at least 1.0 mM of the ...

METHOD AND APPARATUS FOR ADJUSTING CORNEAL CURVATURE THROUGH DIGITAL CORNEAL CROSSLINKING

The present disclosure concerns a digital corneal crosslinking technology for adjusting the corneal curvature, comprising the following steps: administering in drops a composition comprising a photoinitiator compound to the corneal stromal of the subject, locally irradiating the corneal by utilizing digital micromirror device controlled by computer. The corneal curvature can be adjusted totally or locally. The invention also discloses an apparatus for the digital corneal crosslinking. The method and apparatus is minimum invasive and can be used to accurately and efficiently adjust the corneal curvature. 1. A method of digitally adjusting a corneal curvature of an eye in a subject , the method comprising the steps of: dropping a composition comprising a photoinitiator compound to the corneal stromal of the subject , locally irradiating the corneal by utilizing a digital micromirror device controlled by graphic software in a computer , whereby the corneal curvature is altered.2. The method of claim 1 , wherein the photoinitiator is selected from riboflavin claim 1 , riboflavin derivatives claim 1 , eosin Y claim 1 , eosin Y derivatives claim 1 , acriflavine claim 1 , quinidine claim 1 , methylene blue claim 1 , or erythrosine.3. The method of claim 2 , wherein when the photoinitiator is riboflavin or riboflavin derivatives claim 2 , wavelength of light is 320-400 nm; and wherein when the photoinitiator is eosin Y claim 2 , eosin Y derivatives claim 2 , acriflavine claim 2 , quinidine claim 2 , methylene blue and erythrosine claim 2 , the wavelength is 460-668 nm.4. The method of claim 1 , wherein the amount of the photoinitiator ranges from 0.01 to 0.5% by weight.5. The method of claim 1 , wherein the composition additionally contains an assisting penetrating agent.6. The method of claim 5 , wherein the penetrating agent is selected from EDTA claim 5 , EDTA sodium claim 5 , EDTA potassium claim 5 , polysorbate 80 claim 5 , trometamol claim 5 , azone claim 5 , benzoyl ...

SYSTEMS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material.

APPARATUS AND METHOD FOR APPLYING LIGHT IN OCULAR AND PERIOCULAR AREAS

A removable tip for a light energy handpiece comprises a hollow conduit configured to surround a light guide in the handpiece; a support extension having a length longer than a length of the hollow conduit; and a shielding extension coupled to the support extension at an angle less than 180 degrees and located in front of the hollow conduit. The shielding extension is configured to be inserted behind an eyelid and extend to the fornix, the shielding extension comprised of a thermally insulative material. 1. A method of protecting ocular tissue during application of light energy , the method comprising:providing a handpiece having a light energy device, the handpiece having a tip having a shielding extension configured to be inserted posterior to an eyelid;inserting the shielding extension behind the eyelid to the fornix prior to applying light energy to an anterior surface of the eyelid;applying light energy from the light energy device to an anterior surface of the eyelid;wherein the light energy device is configured to produce one of: LED energy or laser energy; andwherein the shielding extension is comprised of a thermally insulative material such that energy not absorbed by a target tissue is prevented from reaching ocular tissue located posterior to the eyelid.2. The method of claim 1 , wherein the shielding extension is configured to be inserted posterior to an eyelid between the ocular conjunctiva and palpebral conjunctiva.3. The method of claim 1 , wherein the tip is a removable tip.4. The method of claim 3 , wherein the removable tip comprises:a hollow conduit configured to surround a light guide in the handpiece;a support extension having a length longer than a length of the hollow conduit; anda shielding extension coupled to the support extension to an angle less than 180 degrees and located distal to the hollow conduit; andthe shielding extension configured to be inserted behind an eyelid and extend to the fornix, the shielding extension comprised of a ...

METHODS FOR PREVENTING AND TREATING OCULAR DISEASE

Methods for preventing and/or treating ocular diseases such as dry age-related macular degeneration, and/or improving or maintaining a retinal function, include administering non-invasive photobiomodulation light therapy in the context of a prior PBM treatment, on the basis of a patient pre-treatment characteristic. In some embodiments, methods comprise administering PBM therapy to subjects prior to onset of, or in early stages of, dry age-related macular degeneration. 1. A method for preventing or delaying onset and/or progression of dry age-related macular degeneration (dry AMD) in an eye of a subject , the method comprising administering to the eye an effective amount of photobiomodulation (PBM) light comprising:(i) light having a wavelength in a red wavelength range; and/or(ii) light having a wavelength in a near-infrared (NIR) wavelength range, when the eye of the subject exhibits any one or more of (a)-(p):(a) hypo-pigmentation of the retinal pigment epithelium (RPE);(b) hyper-pigmentation of the RPE;(c) mottling of the RPE;(d) vacuolation in the RPE and/or the sub-RPE space;(e) multivesicular bodies in the RPE and/or the sub-RPE space;(h) a region of partial or complete loss of RPE;(g) drusen or drusen-like deposits;(h) accumulation of lipofuscin;(i) spontaneous choroidal neovascularization (CNV);(j) subretinal hemorrhage;(k) subretinal cellular infiltrates;(m) basal laminar deposits in the RPE;(n) a region of thickening of Bruch's membrane;(o) an ERG response amplitude of a b-wave that is reduced as compared to a ERG response amplitude of a b-wave in a healthy eye;(p) an ERG response amplitude of an a-wave that is reduced as compared to a ERG response amplitude of an a-wave in a healthy eye.2. A method for preserving or improving a retinal function in an eye of a subject , the method comprising administering to the eye an effective amount of photobiomodulation (PBM) light comprising:(i) light having a wavelength in a red wavelength range; and/or(ii) light ...

Methods for preventing and treating diabetic retinopathy and diabetic macular edema

The present disclosure provides methods for preventing or treating ocular diseases such as diabetic retinopathy and diabetic macular edema, wherein the methods include administering non-invasive photobiomodulation light therapy comprising a light having a wavelength in a red wavelength range. Biomarkers and diagnostic assays for selecting a treatment are also provided.

MINIMALLY INVASIVE GLAUCOMA SURGICAL INSTRUMENT AND METHOD

Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal. 1. A device useable for removing trabecular meshwork tissue from the eye of a subject , said device comprising:an elongate probe comprising a probe shaft having a distal end, a hollow inner chamber and an opening near its distal end;a movable cutter disposed within the hollow inner chamber; anda member extending at an angle from the distal end of the probe shaft, said member having a tip, an upper side and a lower side, the opening being located adjacent to the upper side of the member;the probe shaft being insertable into the anterior chamber of the eye and the distal tip of the member being thereafter advanceable through the trabecular meshwork thereby positioning the member in Schlemm's canal with an opposing wall of Schlemm's canal juxtaposed to the lower side of the member and trabecular meshwork tissue juxtaposed to the upper side of the member; andthe moveable cutter being operable to sever trabecular meshwork tissue that passes through the opening.2. A device according to wherein the member is configured so as to be advanceable through Schlemm's canal in a manner that causes trabecular meshwork tissue to ride over the upper side of the member and through the opening.3. A device according to further comprising an aspiration lumen useable for aspirating trabecular meshwork tissue through the opening.4. A device according to further comprising an aspiration pump that is attachable to the aspiration lumen.5. A device according to wherein the moveable cutter rotates.6. A device according to wherein the moveable cutter comprises a rotating cutting head.7. ...

DRY EYE TREATMENT SYSTEM WITH DISPOSABLE TIP AND CORNEAL SHIELD

A system for the treatment of the dry eye syndrome that is based on a light source. The system includes a disposable tip, to treat an eyelid. A corneal shield is used to protect the patient's eye. 1. A corneal shield for placement on a patient's eye to protect the eye and its surrounding tissues during light treatment from a light energy source comprising:{'b': ['61', '62', '8'], '#text': "a body having an outer surface (), configured to be placed to face in the direction of the light energy source and an inner surface (), configured in shape to the shape of the human cornea () and to be placed on the patient's cornea;"}wherein the shield is comprised of a flexible biocompatible material that is made of an at least partially light absorbing material.2. The corneal shield according to wherein the biocompatible material is one of silicon or a thermoplastic elastomer. The corneal shield according to wherein the material is doped with TiO(titanium(II)oxide).46. The corneal shield according to wherein the corneal shield () material is doped with around 20% TiO.56. The corneal shield according to wherein the corneal shield () material is doped with TiO(titanium(II)oxide) configured to transmit less than 30% of the light energy claim 1 , based on light energy from the light energy source onto the shield in the range of 5-20 J/cm.66. The corneal shield according to wherein the corneal shield () is a coated scleral contact lens coated with one or more layers of bio-compatible pigment.76. The corneal shield according to wherein the corneal shield () is coated with one or more coating layers applied on the surface of the shield that is configured to be placed in contact with the internal side of the patient's eyelid.86. The corneal shield according to wherein the corneal shield () is a contact lens comprised of one or more materials to block treatment light.9. The corneal shield according to wherein the corneal shield has a generally dome shape claim 1 , the open end being ...

DEVICES AND METHODS FOR NON-INVASIVE MULTI-WAVELENGTH PHOTOBIOMODULATION FOR OCULAR TREATMENTS

An ophthalmic phototherapy device and associated treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The device includes a housing having an interior; an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing; a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, where the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm. 1. A self-standing device for delivery of light therapy to ocular tissue of an eye of a patient , the device comprising:a housing comprising an interior;an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece;a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing;a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, wherein the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm; andan aperture disposed within the housing, wherein the device is configured and arranged to direct the first and second light beams through the aperture and through the eyepiece to provide light therapy to the eye of the patient.2. The device of claim 1 , further comprising a third light source producing a third light beam having a third therapeutic wavelength and disposed within the housing claim 1 , wherein the third therapeutic wavelength differs from the first and second therapeutic wavelengths by at least 25 nm.3. The device of claim 1 , wherein the first light source is configured and arranged to emit a pulsed light beam comprising a plurality of ...

WEARABLE DEVICES AND METHODS FOR MULTI-WAVELENGTH PHOTOBIOMODULATION FOR OCULAR TREATMENTS

A wearable ophthalmic phototherapy device and associated treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The device includes a frame having a front piece and two earpieces extending from the front piece; and at least one light source producing a light beam having a therapeutic wavelength and disposed within or on the frame. The devices can include multiple different light sources to produce light with therapeutic wavelengths that differs from each other by at least 25 nm. 1. A wearable device for delivery of light therapy to ocular tissue of an eye of a patient , the device comprising:a frame comprising a front piece and at least one affixation element attached to the front piece;at least one first light source producing a first light beam having a first therapeutic wavelength and disposed within or on the frame; andat least one second light source producing a second light beam having a second therapeutic wavelength and disposed within or on the frame, wherein the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm,wherein at least a portion of the first and second light beams are directed toward the eye of the patient when the patient is wearing the wearable device.2. The device of claim 1 , further comprising at least one third light source producing a third light beam having a third therapeutic wavelength and disposed within or on the frame claim 1 , wherein the third therapeutic wavelength differs from the first and second therapeutic wavelengths by at least 25 nm.3. The device of claim 1 , wherein the first wavelength is in a range from 800 to 900 nm and the second wavelength is in a range from 600 to 700 nm.4. The device of claim 1 , wherein the first wavelength is in a range from 800 to 900 nm and the second wavelength is in a range from 550 to 650 nm.5. The device of claim 2 , wherein the first wavelength is in a range from 800 to 900 ...

OPHTHALMIC TREATMENT DEVICE, SYSTEM, AND METHOD OF USE

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking. 1. An ophthalmic treatment system , comprising:a light source device;at least one optical treatment head operatively coupled to the light source device, and providing at least one treatment light; anda light control device, which controls operation of the light source to provide discontinuous treatment light projection onto an eye; and/or adjusts intensity of part or all of the light source, providing adjusted intensity treatment light projection onto an eye.2. The system of claim 1 , wherein the light control device is configured to provide discontinuous treatment light projection from the optical treatment head onto the cornea and/or sclera at a treatment light exposure period of between one second and 10 minutes.3. The system of claim 2 , wherein the controller has an input for operator selection of parameters and duration for the discontinuous light projection on the cornea and/or sclera.4. The system of claim 2 , wherein each treatment light exposure period of the discontinuous treatment light projection is in the range from 5 seconds to 25 seconds.5. The system of claim 1 , wherein the treatment light is selected from the group consisting of UVA light claim 1 , a mixture of UVA and blue light claim 1 , and blue light.6. The system of ...

DEVICES AND METHODS FOR TREATING EYELIDS

An ocular protection device and treatment methods are disclosed. The device has a corneal shield with an attached handle. The handle may be used to move the corneal shield to better protect the eye from various treatment modalities. The handle may also be used to place tension on the eyelid to counteract the forces imposed by a treatment handpiece. A procedure for treating the eye is disclosed where multiple passes with a treatment handpiece cause a gradual increase in the temperature of an eyelid up to a treatment temperature. Once the treatment temperature has been met, occlusions in the Meibomian glands of the eyelid may be expressed. The procedure may be repeated recursively until a desired level of expression has been achieved. 1. An ocular protection device comprising:a corneal shield configured to fit underneath eyelids, the corneal shield having a sufficiently smooth inner surface to prevent damage to an eye;a handle rigidly connected to an outer surface of the corneal shield, the handle configured to protrude between closed eyelids; andwherein the handle is sufficiently long to allow an operator to control the corneal shield via the handle while having an unobstructed view and access to the eyelids.2. The device of claim 1 , wherein the handle has a length of at least about 25 mm.3. The device of claim 1 , wherein the handle and shield are integrally formed.4. The device of claim 1 , wherein the handle has a hinge that is offset from the corneal shield.5. The device of claim 4 , wherein the hinge is offset from the corneal shield by at least 15 mm.6. The device of claim 4 , wherein the hinge is a living hinge.7. The device of or claim 4 , wherein the hinge is a mechanical hinge selected from a group consisting of a revolute joint and a ball joint.8. The device of claim 1 , further comprising a junction piece that joins sections of the handle together.9. The device of claim 8 , wherein the junction piece includes a living hinge.10. The device of claim 8 , ...

METHOD OF ALTERING THE REFRACTIVE PROPERTIES OF AN EYE

The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye. 1. A method of altering the refractive properties of the eye , said method comprising:applying a photosensitizer to interior tissue of a cornea of an eye, the photosensitizer facilitating cross-linking of the interior tissue of the cornea;irradiating the cornea so as to activate cross-linkers in the interior tissue of the cornea and thereby stiffen the cornea and prevent corneal ectasia of the cornea; andafter the cornea has been stiffened by the activation of the cross-linkers, ablating a front surface of the cornea so as to change the refractive properties of the eye.2. The method according to claim 1 , wherein the photosensitizer comprises riboflavin.3. The method according to claim 1 , wherein the step of irradiating the cornea so as to activate cross-linkers in the interior tissue of the cornea comprises irradiating the cornea with at least one of ultraviolet light and microwaves.4. The method according to claim 1 , wherein the front surface of the cornea is ablated using an excimer laser in order to change the refractive properties of the eye.5. The method according to claim 1 , wherein the step of ablating a front surface of the cornea so as to change the refractive properties of the eye comprises performing a photorefractive keratotomy (PRK) procedure on the front surface of the cornea.6. A method of altering the refractive properties of the eye claim 1 , said method comprising:forming a pocket in a cornea of an eye of a patient so as to gain access to tissue bounding the pocket, wherein the forming of the pocket in the cornea of the eye severs some corneal nerves supplying a front surface of ...

SEMI-AUTOMATED OPHTHALMIC PHOTOCOAGULATION METHOD AND APPARATUS

An ophthalmic treatment system is configured to perform scanning of target tissue in a patient's eye to at least visualize the target tissue. The scanning pivots about a patient's iris to scan a retina. 1. An ophthalmic treatment system configured to perform scanning of target tissue in a patient's eye to at least visualize the target tissue , the ophthalmic treatment system comprising:a scanner configured to perform the scanning;a zoom system before a light for performing therapy on the target tissue enters the scanner; andcontrol electronics configured to control at least the scanning by the scanner.2. The ophthalmic treatment system of claim 1 , further comprising a device configured to perform the scanning claim 1 , wherein the device is an ophthalmoscope claim 1 , a slit lamp biomicroscope claim 1 , a fundus camera claim 1 , a scanning laser ophthalmoscope claim 1 , or an optical coherence tomography system.3. The ophthalmic treatment system of claim 1 , further comprising a device configured to perform the scanning claim 1 , wherein the scanning pivots about a patient's iris to scan a retina. This application is a divisional of U.S. patent application Ser. No. 14/733,363 filed on Jun. 8, 2015, which is a division of U.S. patent application Ser. No. 11/868,387 filed on Oct. 10, 2007, the entire contents of each of which is hereby incorporated by reference herein.The present invention pertains generally to the ophthalmic treatment of a patient's eye, and more particularly to a machine and method for semi-automated ophthalmic photomedical treatment of a patient's eye.Presently, conditions such as diabetic retinopathy, vein occlusion and age-related macular degeneration have been treated with photocoagulation induced by visible laser light. While this type of visible laser light treatment may halt the progress of the underlying disease, it can be problematic.One problem is that some ophthalmic treatments require the application of a large number of laser doses to ...

Phototherapy Devices and Methods Comprising Optionally Substituted Quinquiesphenyl Compounds

Methods and devices related to the treatment of diseases using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring System 1, Ring System 2, Ring System 3, Ring System 4 or Ring System 5. Methods of treating disease with phototherapy are also described.

SYSTEM AND PROCEDURE FOR ENHANCING OCULAR DRAINAGE

Various systems, apparatuses, and processes may be used for enhancing ocular drainage. In particular implementations, a system for ocular drainage may include an ocular interface that includes a base and a number of diathermy needles. The diathermy needles may extend from the base a distance sufficient to penetrate a sclera of an eye and provide radio frequency energy to a trabecular meshwork. 1. A system for enhancing ocular drainage , the system comprising: 'a base;', 'an ocular interface comprisinga plurality of diathermy needles extending from a side of the base, the needles extending a distance sufficient to penetrate a sclera of an eye and provide radio frequency signal energy to a trabecular meshwork therein.2. The system of claim 1 , wherein the base is an annular ring that is sized to fit around a cornea.3. The system of claim 1 , wherein the diathermy needles comprise an outer layer of insulation that extends from an end of the needles near the base to a location adjacent to a distal end of the needles.4. The system of claim 1 , further comprising an electrical signal source coupled to the ocular interface claim 1 , the electrical signal source adapted to apply a high frequency radio signal to the diathermy needles.5. The system of claim 4 , wherein the electrical signal source is adapted to generate a radio frequency signal between 3 and 5 MHz.6. The system of claim 4 , wherein the electrical signal contracts the trabecular meshwork in the vicinity of the needles claim 4 , which causes a large portion of the trabecular meshwork to stretch.7. The system of claim 1 , where the ocular interface comprises more than 20 diathermy needles.8. The system of claim 1 , wherein the diathermy needles are monopolar.9. The system of claim 1 , wherein the diathermy needles are bipolar.10. A method comprising:positioning an ocular interface comprising a base and a plurality of diathermy needles extending therefrom in the vicinity of a patient's cornea;moving the ocular ...

Systems and Methods for Cross-Linking Treatments of an Eye

An example system for corneal treatment includes an illumination system to generate cross-linking in at least one selected region of a cornea treated with a cross-linking agent by delivering photoactivating light according to one or more photoactivation parameters. The system includes a controller to receive input relating to one or more treatment parameters, which include the one or more photoactivation parameters. The controller is configured to output information for adjusting the one or more treatment parameters by (A) determining from the input, a distribution of cross-links for the at least one selected region of the cornea; (B) determining, from the distribution of cross-links, a shape change for the cornea; and (C) determining, from the shape change for the cornea, a change in vision for the subject. Responsive to the output from the controller, the illumination system is configured to adjust at least one of the one or more photoactivation parameters.

System and method for directing light into a patients eye

Disorders of the eye can be treated by photobiomodulation therapy according to a device designed to direct light into a patient's eye, no matter the configuration of the eye. The device, including a printed circuit board that includes an array of light delivery devices and a heat sink lens, can be placed proximal to the patient's eye. The light delivery devices can be powered to generate light. The light can be directed into the patient's eye regardless of a position of the patient's eye.

Laser therapy system and method for treatment of a collagen structure and of varicose blood vessels in an eye

The present invention refers to a Laser therapy system and a method for treatment of a sclera/conjunctiva of an eye, comprising: a dispenser for a photosensitizer agent; a 3D imaging unit; an image processing unit being adapted to recognize the collagen tissue structure and to determine a thickness thereof; a UVA light source being adapted to a crosslinking of the collagen tissue; a second Laser light source being adapted to be absorbed mainly by varicose blood vessels; an optical system for deflecting and focusing the UVA light and the second Laser light on a focus point within the sclera/conjunctiva; a processing and control unit being adapted to determine a target thickness and a thickness deviation; a pattern for an application of the UVA light energy; a UVA light energy to effect a growth of the collagen tissue structure until the target thickness is achieved.

SYSTEMS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. 117-. (canceled)18. A system for treating meibomian gland disease in at least a portion of an eyelid by a clinician , comprising:a back plate sized to be positioned between an eyeball and an eyelid of a patient;a compressive element mechanically linked to the back plate, the compressive element positionable adjacent to the outer surface of the eyelid while the back plate of the treatment device is positioned between the eyeball and the eyelid, wherein the back plate and the compressive element collectively define an aperture between the back plate and the compressive element such that the aperture provides a line of sight that permits viewing of an eyelid margin by the clinician through the aperture when the backplate is positioned between an eyeball and an eyelid of a patient;a light-emitting device that emits light energy, the light-emitting device positionable outside of the eyelid while the back plate is positioned between the eyeball and the eyelid, wherein the light-emitting device can emit light to heat tissue of the eyelid adjacent to the meibomian glands of the patient to a temperature sufficient to melt or soften meibum of the meibomian glands;a housing, wherein the back plate, the light-emitting device, and the compressive element are mechanically coupled to the housing.19. The system of claim 18 , wherein the compressive element is mechanically linked to the back ...

Systems and Methods For the Treatment of Eye Conditions

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region. 120-. (canceled)21. A device for treating a mammalian eye having an eyelid , comprising:a shield formed of a plate positionable proximate an inner surface of an eyelid, the shield including an energy-reflecting material that reflects light energy;an energy transducer having a device that emits light energy, the energy transducer positionable outside of the eyelid when the shield is positioned proximate the inner surface of the eyelid, wherein the energy transducer provides light energy toward the energy-reflecting material at one or more wavelengths, including a first wavelength selected to at least partially pass through the eyelid to the shield and at least partially reflect back toward a target tissue region from the shield; andan energy transmission surface positioned in a spaced relationship with the shield;a housing, wherein the shield, the energy transducer, and the energy transmission surface are mechanically coupled to the housing;an actuator coupled to the housing, wherein actuation of the actuator causes relative movement ...

DEVICE AND OPERATIONAL METHOD FOR PLASMA TREATMENT OF BIOLOGICAL TISSUE

A device for plasma treatment of biological tissue can comprise a hollow needlelike tubular section with a distal end for applying a light-induced plasma to the tissue, wherein the tubular section comprises subsequent to the distal end an inner plasma chamber configured for generating therein a light-induced plasma. In one embodiment, the plasma chamber is communicatively coupled with a distal, central axial aperture in the distal end, and adjoins, within the tubular section, a light injection section for injecting light, in particular laser light pulses, into the plasma chamber for plasma generation. 1. A device for the treatment of biological tissue , in particular for plasma treatment of biological tissue , of for example a human organism , such as for example the trabecular meshwork of the human eye , the device comprising:a hollow needle-like tubular section with a distal end for applying a light-induced plasma to the tissue; the tubular section comprises subsequent to the distal end an inner plasma chamber configured for generating therein a light-induced plasma,', 'the plasma chamber is communicatively coupled with a distal, central axial aperture in the distal end, and adjoins, within the tubular section, a light injection section for injecting light, in particular laser light pulses, into the plasma chamber for plasma generation., 'wherein2. The device according to claim 1 , wherein the aperture claim 1 , the plasma chamber claim 1 , and the light injection section are arranged coaxially with each other claim 1 , in particular with the longitudinal axis (L) of the tubular section.3. The device according to claim 1 , wherein the cross section of the aperture measured perpendicular to the longitudinal axis (L) of the plasma chamber or of the tubular section is in the range from 0.05 mm to 0.5 mm claim 1 , preferably 0.05 mm to 0.3 mm.4. The device according to claim 1 , wherein the distal end of the tubular section is dome-shaped claim 1 , and optionally has ...

Devices and Methods for Novel Retinal Irradiance Distribution Modification to Improve and Restore Vision without Producing Corneal Vitrification

Methods and apparatus to improve or restore vision by causing a rebooting of the visual system of an eye with modification of visual search, sampling and stimulation away from the preferred retinal locus of fixation of an eye to enhance neural integration and perception of visual information from within the field of view are described herein. Some embodiments cause transient, reversible or repeatable redirection of environmental light away from the preferred retinal locus of fixation of an eye to multiple retinal locations that are not the preferred retinal locus of fixation. Some embodiments reduce exposure of environmental light at the preferred retinal locus of fixation of an eye for a determinable interval at a determinable rate. Some embodiments cause a defocusing of environmental light at the preferred retinal locus of fixation in an eye with a visual impairment or loss. 1. An apparatus for improving or restoring vision , the apparatus comprising:one or more clear components positioned anterior to a retina of an eye;one or more transformable components disposed on a surface of, or within, the one or more clear components; anda controller coupled to the one or more transformable components via a conductive component, the controller being configured to generate and route control signals to the one or more transformable components,wherein, upon receipt of the control signals, the one or more transformable components reorganize at least one pattern of a direction of environmental light from within a field of view of the eye to the retina at a determinable rate up to 50 kilohertz, andwherein the at least one pattern causes a defocusing at the preferred retinal locus of fixation of the eye and wherein the at least one pattern does not generate an aperture.2. The apparatus of claim 1 , wherein the at least one pattern of direction of environmental light to the retina causes a focusing at a plurality of non-contiguous retinal locations that are not the preferred ...

SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY

Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided. 1. A system for activating a cross-linking agent applied to a cornea of an eye , comprising:a light source including a light emitting diode for emitting a non-ablative photoactivating light;a digital micromirror device (DMD) including a plurality of mirrors arranged in a matrix, the plurality of mirrors configured to selectively reflect the photoactivating light from the light source to provide a pixelated illumination to be directed to a cornea of an eye, the pixelated illumination including pixels defined by the mirrors in the DMD;one or more optical elements positioned to direct the pixelated illumination from the DMD to the cornea;a controller configured to control the DMD to programmatically select which of the mirrors reflect the photoactivating light to provide the pixelated illumination to a selected region of the cornea, wherein, at one particular instant in time, the pixelated illumination is defined by a two-dimensional array of the pixels, the controller being configured to control the light source to determine at least one of a power or a duration for the pixelated illumination to generate cross-linking activity in the selected region of the cornea; ...

Ophthalmic treatment device, system, and method of use

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

OPHTHALMIC DOCKING SYSTEM WITH 3-DIMENSIONAL AUTOMATIC POSITIONING USING MAGNETIC SENSING ARRAY

A magnetic positioning system and related method for automated or assisted eye-docking in ophthalmic surgery. The system includes a magnetic field sensing system on a laser head and a magnet on a patient interface to be mounted on the patient's eye. The magnetic field sensing system includes four magnetic field sensors located on a horizontal plane for detecting the magnetic field of the magnet, where one pair of sensors are located along the X direction at equal distances from the optical axis of the laser head and another pair are located along the Y direction at equal distances from the optical axis. Based on relative magnitudes of the magnetic field detected by each pair of sensors, the magnetic field sensing system determines whether the patient interface is centered on the optical axis. The system controls the laser head to move toward the patient interface until the latter is centered on the optical axis. 1. An ophthalmic surgical laser system comprising:a laser delivery head, including optics which define an optical axis for delivering a laser beam to an eye of a patient;an magnetic field sensing system, which includes a first, a second, a third and a fourth magnetic field sensors and a control device electrically coupled to the first through fourth sensors,wherein the first through fourth sensors are affixed on the laser delivery head and located in a plane perpendicular to the optical axis, wherein the first and second sensors have identical structures and are located at equal distances from the optical axis along a first line that passes through the optical axis, wherein the third and fourth sensors have identical structures and are located at equal distances from the optical axis along a second line that passes through the optical axis, andwherein the control device is configured to control each of the first through fourth sensors to measure a magnetic field generated by an external magnet, and based on the measured magnetic field signals by the first ...

Systems and methods for the treatment of eye conditions

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material.

Ocular cross-linking system and method for sealing corneal wounds

Wounds in the eye following surgery or injury are sealed by soaking the area with a riboflavin solution containing iodide ion and irradiating the wound area with UVA radiation in a selected wavelength range for a selected time period to promote cross-linking of tissue between opposite surfaces of the wound or between the incised wound surfaces and a graft or implant.

OPHTHALMIC SURGICAL DEVICE FOR CAPSULOTOMY

A surgical device and procedure are provided for performing microsurgery, including a capsulotomy of a lens capsule of an eye. The device has an elastically deformable cutting element mounted within an elastomeric suction cup. The suction cup is attached to an arm for manipulating the device. The device can be inserted into the anterior chamber of the eye, through a corneal incision, to cut a piece from the anterior portion of the lens capsule of the eye. The device is secured against the lens capsule using suction applied by one or more suction elements. The device is then removed from the eye, with the cut piece of membrane retained within the device by suction. 1. A surgical device for excising tissue , the device comprising:a single continuous cutting element including an annular ring shape with a cross section having an inner edge and an outer edge, wherein the cutting element is collapsible for insertion through an incision in a tissue layer to access the tissue for excision, and wherein the cutting element is configured to return to the annular ring shape after the insertion through the incision;two electrical leads attached to the cutting element such that, when an electrical pulse is applied, the electrical pulse is capable of traveling around the entire annular ring shape of the cutting element; andan arm attached to the cutting element and configured for manipulating the cutting element.2. The device of claim 1 , wherein the two electrical leads are disposed within the arm.3. The device of claim 1 , wherein the two electrical leads are connected to the electrical cutting element on two different sides of an insulating gap in the cutting element such that claim 1 , when the electrical pulse is applied claim 1 , the electrical pulse is capable of traveling from a first of the two electrical leads around the entire annular ring shape of the cutting element to a second of the two electrical leads to excise the tissue.4. The device of claim 3 , wherein the two ...

Capsulotomy device with suction cup compression chamber

A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye. A sliding element is disposed within the handpiece and a suction cup is mounted to the sliding element. The sliding element can be translated to move the suction cup into and out of the handpiece. A compression mechanism associated with the suction cup and the handpiece compresses the suction cup for deployment through the tip of the handpiece. The suction cup can expand inside the anterior chamber into a cutting position on the lens capsule. A cutting element mounted to the suction cup is used to cut a portion of the lens capsule and to remove the portion from the eye.

CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties. 1. A composition of matter comprising a composite of:a naturally occurring in vivo cornea of an in situ eye; andat least one volume of non-naturally occurring conical stromal tissue formed within the naturally occurring corneal stromal tissue of an in vivo cornea of an in situ eye;wherein the at least one volume of non-naturally occurring corneal stromal tissue is at least 1% vitrified thereby modifying its structure and properties from naturally occurring structure and properties to non-naturally occurring glass-like structure and properties;wherein the at least one volume of vitrified non-naturally occurring conical stromal tissue is formed in situ.2. A method , comprising:causing absorption of photon energy, or absorption of acoustic energy, or a combination thereof by in vivo corneal stromal tissue of an in situ eye, thereby resulting in vitrifying at least 1% of at least one treated volume of the in vivo corneal stromal tissue of an in vivo cornea ...

DUAL BLADE OPHTHALMOLOGIC SURGERY DEVICE

A dual blade device and method useable for performing an ab interno procedure within a human eye to remove a strip of trabecular meshwork tissue. 1. A dual blade device useable for performing an ab interno procedure within a human eye to remove a strip of trabecular meshwork tissue , said device comprising:a handle configured to be grasped by an operator's hand;an elongate probe that extends from the handle along a longitudinal axis to a distal end;a blunt protruding tip that extends laterally from the distal end of the probe forming a bend or curve of approximately 30 degrees to approximately 90 degrees relative to the adjacent longitudinal axis of the probe, the blunt protruding tip having a transverse width, a top surface, a bottom surface and a terminal end, the transverse width of the blunt protruding tip being narrowest at its terminal end;first and second laterally directed cutting edges formed at stationary, spaced-apart locations on the distal end of the probe with an area existing between the first and second lateral cutting edges, the first and second lateral cutting edges having top ends and being oriented in side-by-side planes such that they will simultaneously cut tissue that passes over the top surface of the blunt protruding tip and into contact with the first and second lateral cutting edges; anda blunt top edge that extends transversely from the top end of the first lateral cutting edge to the top end of the second lateral cutting edge and traverses above the area between the first and second lateral cutting edges;wherein;a) the top surface of the blunt protruding tip is below the area between the first and second lateral cutting and extends ahead of the first and second lateral cutting edges such that tissue may pass over the top surface of the blunt protruding tip and then into contact with the first and second lateral cutting edges;b) a distal portion of the probe, inclusive of the blunt protruding tip, is sized to pass through an incision ...

Apparatus and method for applying light in ocular and periocular areas

A removable tip for a light energy handpiece comprises a hollow conduit configured to surround a light guide in the handpiece; a support extension having a length longer than a length of the hollow conduit; and a shielding extension coupled to the support extension at an angle less than 180 degrees and located in front of the hollow conduit. The shielding extension is configured to be inserted behind an eyelid and extend to the fornix, the shielding extension comprised of a thermally insulative material.

Semi-automated ophthalmic photocoagulation method and apparatus

An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

REAL TIME ACOUSTIC DOSIMETRY FOR CORNEAL COLLAGEN CROSSLINKING

A change in the response of the cornea to ultrasonic energy directed into the cornea is monitored during irradiation of the cornea to bring about corneal crosslinking. Because the change in ultrasonic response is correlated with the degree of crosslinking achieved, a desired degree of crosslinking can be achieved by terminating the irradiation when the change reaches a threshold. The change in ultrasonic response can be determined by taking a baseline measurement before irradiation and additional measurements during irradiation using the same ultrasonic transducer (). The transducers may be carried on a device () resembling a contact lens which overlies the eye and which transmits the light used in the irradiation step to the eye. 1. A device for applying irradiation and ultrasound to an eye of a subject comprising:(a) a housing having an inwardly-facing surface adapted to rest on an anterior surface of the eye;(b) an optical diffuser mounted to the housing, the diffuser having inner and outer surfaces facing inwardly toward and outwardly; and(c) a ultrasonic transducer mounted to the housing and disposed outward of the diffuser so that the diffuser is disposed between the transducer and the eye when the housing rests on the anterior surface of the eye.2. A device as claimed in wherein the ultrasonic transducer includes a piezoelectric element and a metallic electrode disposed between the piezoelectric element and the diffuser claim 1 , the metallic electrode being reflective to light.3. A device as claimed in wherein the piezoelectric element is a polymeric piezoelectric film.4. A device as claimed in further comprising a foam backing disposed outward of the polymeric piezoelectric film.5. A device as claimed in wherein the foam backing is electrically conductive.6. A device as claimed in wherein the ultrasonic transducer is coaxial with the diffuser.7. A device as claimed in wherein the housing includes a peripheral portion facing inwardly claim 1 , the peripheral ...

Systems and Methods for Generating Patient-Specific Corneal Cross-Linking Treatment Patterns

An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.

DEVICES AND METHODS FOR NON-INVASIVE MULTI-WAVELENGTH PHOTOBIOMODULATION FOR OCULAR TREATMENTS

An ophthalmic phototherapy device and associated treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The device includes a housing having an interior; an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing; a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, where the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm. 120-. (canceled)21. A device for delivery of photobiomodulation (PBM) to retinal tissue of an eye of a patient , the device comprising:a housing comprising an interior;an eyepiece or eyebox configured and arranged for placement of at least one eye of the patient adjacent the eyepiece or eyebox;a first light source selected from one or more LED, lamp, or laser, or any combination thereof, wherein the first light source is configured to produce a first light beam having a first therapeutic wavelength, and wherein the first light source is disposed within the housing;a second light source selected from one or more LED, lamp, or laser, or any combination thereof, wherein the second light source is configured to produce a second light beam having a second therapeutic wavelength, wherein the second light source is disposed within the housing, and wherein the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm;a relay structure configured and arranged to receive the first light beam and the second light beam from the first light source and the second light source, respectively, and to direct the first light beam and the second light beam to the eyepiece or eyebox; andan actuator configured and arranged to move at least a portion of the ...

APPARATUS AND METHOD FOR APPLYING LIGHT IN OCULAR AND PERIOCULAR AREAS

A removable tip for a light energy handpiece comprises a hollow conduit configured to surround a light guide in the handpiece; a support extension having a length longer than a length of the hollow conduit; and a shielding extension coupled to the support extension at an angle less than 180 degrees and located in front of the hollow conduit. The shielding extension is configured to be inserted behind an eyelid and extend to the fornix, the shielding extension comprised of a thermally insulative material. 1. A light energy delivery system comprising:a console comprising a power supply and control electronics; anda handpiece coupled to the console, the handpiece configured to produce light energy based on power and control signals provided by the console;wherein the handpiece includes a removable tip having a shielding extension configured to be inserted posterior to an eyelid between the ocular conjunctiva and palpebral conjunctiva; andwherein the shielding extension is comprised of a thermally insulative material such that energy not absorbed by a target tissue is prevented from reaching ocular tissue located posterior to the eyelid.2. The system of claim 1 , wherein the handpiece is configured to produce intense pulsed light energy.3. The system of claim 1 , wherein the handpiece is configured to produce LED energy.4. The system of claim 1 , wherein the handpiece is configured to produce laser energy.5. A removable tip for a light energy handpiece claim 1 , the removable tip comprising:a hollow conduit/cavity configured to surround a light guide in the handpiece;a support extension having a length longer than a length of the hollow conduit/cavity; anda shielding extension coupled to the support extension at an angle less than 180 degrees and located distal to the hollow conduit; andthe shielding extension configured to be inserted behind an eyelid and extend to the fornix, the shielding extension comprised of a thermally insulative material.6. The system of claim 5 ...

PARALIMBAL LASER PROBE

A probe as disclosed herein is capable of treating both the Schlemm's canal (SC) and the trabecular meshwork (TM), or both the pars plicata and the iris root site of the eye, with electromagnetic radiation (e.g., laser light) to improve aqueous humor outflow and thus decrease intraocular pressure (IOP). The laser probe can include a tip capable of being placed on an eye, such as on a corneal limbus or a scleral limbal area of the eye. The tip can include an optical waveguide angled to direct laser light through both the SC and TM, or both the pars plicata and the iris root site of the eye. The laser light can be continuous or pulsed, and can be configured to provide appropriate therapy to both the SC and TM, or to both the pars plicata and the iris root site. The laser probe can facilitate performing trans-scleral trabeculoplasty treatment, especially trans-scleral Schlemm trabeculoplasty, and performing iridoplasty treatment. 1. A paralimbal probe , comprising:a probe tip shaped to mate with a surface of an eye at or near a corneal limbus of the eye, the eye having a Schlemm's canal and trabecular meshwork; anda waveguide positioned within the probe tip to convey electromagnetic radiation from a source of electromagnetic radiation into the eye,wherein the waveguide is oriented to direct the electromagnetic radiation along a treatment path intersecting the Schlemm's canal and the trabecular meshwork.2. The probe of claim 1 , wherein the waveguide is further positioned within the probe tip such that the treatment path further intersects paralimbal tissue of the eye.3. The probe of claim 1 , wherein the waveguide is further positioned within the probe tip such that the treatment path further intersects corneal tissue of the eye or scleral tissue of the eye.4. (canceled)5. The probe of claim 1 , wherein the waveguide is an optical waveguide and the source of electromagnetic radiation is a light source or a laser.6. (canceled)7. The probe of claim 1 , wherein the probe ...

OPTICAL SYSTEM FOR EYE SURGERY AND METHOD FOR AVOIDING AN EXCESSIVE LIGHT INTENSITY AT A DIGITAL IMAGE SENSOR OF A SURGICAL MICROSCOPE

An optical system for eye surgery, comprising at least a surgical microscope, an illumination unit for emitting illumination light, and a control unit. 1. An optical system for eye surgery , comprising at least a surgical microscope , an illumination unit for emitting illumination light , and a control unit , at least one digital image sensor,', 'at least one eye piece,', 'a digital observation mode in which a digital image of the observation region is created using the at least one digital image sensor, said image being observed by way of at least one display,', 'a non-digital observation mode in which the observation region is observed through the at least one eye piece without digital means being interposed, and', 'at least two modes of operation,, 'the surgical microscope comprising the surgical microscope being configured to output an observation mode signal indicating the employed observation mode and a mode-of-operation signal indicating the employed mode of operation,', 'the control unit being configured to receive the observation mode signal and the mode-of-operation signal from the surgical microscope and to output a change signal which prompts a change in the amount of light received by the at least one digital image sensor, the control unit being configured to output the change signal only if the received observation mode signal and the received mode-of-operation signal indicate a predetermined combination of observation mode and mode of operation., 'and with'}2. The optical system as claimed in claim 1 , wherein one of the modes of operation is a mode of operation for posterior segment surgery claim 1 , the change signal is suitable for prompting a reduction in the amount of light received by the at least one digital image sensor and the output of the change signal requires that the mode-of-operation signal indicates the mode of operation for posterior segment surgery and the observation mode signal indicates the digital observation mode.3. The optical ...

PROCESS FOR DOSING A CHROMOPHORIC AGENT IN A CORNEAL TISSUE AND APPARATUS FOR CONTROLLING THE DOSING

Control apparatus () for controlling the dosing of a chromophoric agent () in a corneal tissue (), comprising: a first source () for irradiating the corneal tissue () with at least a first electromagnetic radiation (); first measurement means () for measuring a first spectroscopic parameter (), such as the fluorescence intensity or the diffused intensity; a processing unit () configured to calculate a factor (C) representative of the concentration of the chromophoric agent () inside the corneal tissue () in response to at least two measurements of the first spectroscopic parameter (), of which one measurement is indicative of the energy perturbation caused by the first electromagnetic radiation () in the corneal tissue () without the chromophoric agent () and the further measurement is indicative of the energy perturbation caused by the first electromagnetic radiation () in the corneal tissue () containing the chromophoric agent (). 2. The method according to claim 1 , wherein said chromophoric agent is a fluorophore claim 1 , said first electromagnetic radiation having a wavelength selected so as to cause the fluorescence effect of said fluorophoric agent claim 1 , said first spectroscopic parameter being the fluorescence intensity claim 1 , so that the measurement of the first spectroscopic parameter corresponds to the value of the fluorescence intensity of the corneal tissue without the fluorophoric agent and the further measurement of the first spectroscopic parameter corresponds to the value of the fluorescence intensity of the corneal tissue containing said fluorophoric agent.3. The method according to claim 1 , wherein said first electromagnetic radiation has a wavelength selected so as to be absorbed by said chromophoric agent claim 1 , said first spectroscopic parameter being the diffused intensity claim 1 , so that the measurement of the first spectroscopic parameter corresponds to the value of the intensity diffused by the corneal tissue without the ...

NARROW ANGLE ILLUMINATION RING FOR OPHTHALMIC SURGICAL LASER SYSTEM

A narrow angle illumination light source for an ophthalmic surgical laser system includes multiple light emitting diodes (LEDs), multiple corresponding ball lenses, multiple corresponding upper apertures located between the LEDs and the lenses (optional), and multiple corresponding lower apertures located below the lenses. The light passing through each upper aperture and corresponding lens forms a light cone having a defined divergence angle and cone axis angle; the light cone only illuminates the corneal and sclera of a docked eye without illuminating the patients nose and orbit. The lower apertures may have distinctive shapes to aid video focusing. The multiple LEDs are distributed uniformly in the circle, and may be divided into multiple independently controllable segments which allows directional illumination The LEDs also have controllable brightness to allow images of darker and brighter illuminations to be taken in short succession. 1. An illumination light source for an ophthalmic surgical laser system , comprising:a ring shaped housing, having a plurality of lower apertures located in a bottom portion and forming a circle;a plurality of lenses disposed in a circle within the housing, each lens being located above one of the plurality of lower apertures;a ring shaped upper mask disposed within and concentrically with the housing, located above the plurality of lenses, the upper mask having a plurality of upper apertures formed thereon in a circle, each upper aperture being located above one of the plurality of lenses;a ring shaped circuit board disposed concentrically with the housing; anda plurality of light emitting devices disposed on the circuit board forming a circle, the plurality of light emitting devices located above the upper mask and having light emitting surfaces facing the upper mask, each light emitting device being locate above one of the upper apertures;wherein light emitted by each light emitting device, after passing through the ...

LIGHT THERAPY FOR EYELASH GROWTH

Systems, methods, and devices for promoting eyelash hair growth includes an energy transducer, positionable proximate the eyelid, configured to provide light energy to a user's eyelids at an output wavelength suitable for stimulating eyelash hair growth, and a scleral shield, positionable inside of the eyelid, to protect the eye from the light energy. The device may be powered by an internal power source, such as a rechargeable battery or disposable batteries, or by an external power source, such as a plug used in connection with an AC outlet. In use, the eyelid is positioned between the energy transducer and the scleral shield, and the light energy from the energy transducer is applied to the eyelash region of the eyelid to promote eyelash hair growth. 1. A light therapy device for stimulating and/or promoting eyelash growth , comprising:an energy transducer configured to provide light energy at one or more wavelengths to an eyelash region of an eyelid; anda scleral shield configured to block light energy toward the eyeball;wherein when the eyelid is positioned between the energy transducer and the scleral shield, the energy transducer provides light energy at a first wavelength to the eyelash region suitable for stimulating and/or promoting eyelash hair growth, and the scleral shield blocks and/or protects the eyeball from the light energy.2. The device of wherein the first wavelength for eyelash hair growth is within a wavelength range of 450 nm-700 nm.3. The device of claim 1 , wherein the energy transducer is further configured to provide light energy at a second wavelength to treat bacteria on the eyelid.4. The device of wherein the second wavelength is within a wavelength range of 400 nm-450 nm.5. The device of claim 1 , wherein the energy transducer is further configured to provide light energy at a third wavelength to heat the eyelid and soften or melt meibum within meibomian glands.6. The device of wherein the third wavelength is within a wavelength range ...

CAPSULAR MEMBRANE TREATMENTS TO INCREASE ACCOMMODATIVE AMPLITUDE

This apparatus treats the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may be located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion. 1. An apparatus to treat an eye , the eye having a lens and a capsule , the lens capsule having an intermediate portion extending between a central portion of the lens capsule and a peripheral portion of the lens capsule , the apparatus comprising:a deflectable structure coupled to the intermediate portion of the lens capsule to deliver an agent to the intermediate portion so as to stiffen the intermediate portion to increase curvature or movement anteriorly of at least a portion of the lens when the eye accommodates.2. The apparatus of claim 1 , wherein the intermediate portion is treated to stiffen the intermediate portion without shrinking substantially tissue of the intermediate portion such that far vision of the eye is maintained.3. The apparatus of claim 2 , wherein the intermediate portion is stiffened such that far vision of the eye is maintained to within about 1 D and the an amount of accommodation of the eye is ...

APPARATUS FOR PHOTOTHERAPY OF THE EYE

A device and method for applying light to the cornea of the eye as, for example, to promote crosslinking of collagen in the cornea for vision correction. The device may include a structure having form and size similar to a conventional contact lens. The structure may include an optically dispersive element such as a mass of an optically dispersive material that may be contained in a cavity of a reflective element. Light applied to the dispersive mass as, for example, by an optical fiber connected to the structure is dispersed in the structure and passes into the cornea. The patient may blink or close the eye during the procedure, which increases patient comfort and aids in maintaining hydration of the cornea. 1. A method of applying light to the eye of a subject comprising directing light in a direction generally parallel to the surface of the cornea of the eye within an optically dispersive element overlying the surface of the cornea so that light dispersed by the element passes out of the element and into the cornea. The present application is a continuation of U.S. patent application Ser. No. 14/314,518, filed Jun. 25, 2014, which application claims the benefit of the filing date of U.S. Provisional Patent Application No. 61/839,016 filed Jun. 25, 2013, the disclosures of which are hereby incorporated herein by reference.The present application relates generally to devices for applying light such as ultraviolet (“UV”) light to the cornea of the eye; to methods of manufacturing such devices; and to methods of applying phototherapy to the eye.In humans and other mammals, the eye includes a clear, dome-shaped element referred to as the cornea disposed at the front of the eye. Light passes into the eye through the cornea and, after passing through other structures such as the iris and the lens of the eye, ultimately impinging on the retina. The light impinging on the retina is converted to neural impulses that are processed to form the visual images. The cornea and ...

METHODS FOR TREATING EYE CONDITIONS

Architectures and techniques for treating conditions of the eye, such as meibomian gland disease, utilize sources of treatment energy, such as electromagnetic energy emitting devices, to implement manipulations on tissue surrounding the orbit. According to these devices and methods, the sources of treatment energy are activated to direct energy onto parts of the eye, such as the meibomian gland, to treat meibomian gland disease. The treatments can affect at least one property of the eye and allow the liquifactions to flow more freely. 120-. (canceled)21. A method for treating at least one meibomian gland , comprising:a first step of applying electromagnetic energy to the meibomian gland, the electromagnetic energy comprising wavelengths within a range of about 1700 to 2000 microns for absorption by meibum in the meibomian gland, wherein the energy application causes liquefaction of at least a majority of meibum in the meibomian gland without the need for any physical manipulation of the meibomian gland;applying electromagnetic energy comprising mid-infrared energy onto obstructing materials and/or tissues of the meibomian gland using a radial firing tip; andapplying electromagnetic energy comprising near-infrared energy onto at least a portion of the meibomian gland to stimulate at least a portion of the meibomian gland.22. The method of claim 21 , wherein the electromagnetic energy can be used to remove the outer layer of the meibomian gland.23. The method of claim 21 , wherein the electromagnetic energy can be used to kill bacteria that causes the meibomian gland to become clogged.24. The method of claim 21 , wherein the stimulation comprises using CW energy gated electromagnetic energy.25. The method of claim 24 , wherein the stimulation comprises using continuous wave energy gated on for about 200 ms and off for about 200 ms.26. The method of claim 21 , wherein the stimulation restores the meibomian gland production of meibomia to a relatively more youthful ...

Ophthalmic treatment apparatus and beam control method therefor

The present invention relates to an ophthalmic treatment apparatus and to a beam control method therefor. The ophthalmic treatment apparatus according to the present invention comprises: a beam generating unit for generating beams having different pulse energies; a bubble sensing unit for sensing whether or not bubbles have been generated, as well as the amount of generated bubbles, on the basis of the pulse energy of the beam generated by the beam generating unit and radiated onto the treatment region of an eyeball; and a control unit for controlling the operation of the beam generating unit such that the pulse energy of the beam generated by the beam generating unit can be adjusted in accordance with the signal from the bubble sensing unit.

Apparatus For Phototherapy Of The Eye

A device and method for applying light to the cornea of the eye as, for example, to promote crosslinking of collagen in the cornea for vision correction. The device may include a structure having form and size similar to a conventional contact lens. The structure may include an optically dispersive element such as a mass of an optically dispersive material that may be contained in a cavity of a reflective element. Light applied to the dispersive mass as, for example, by an optical fiber connected to the structure is dispersed in the structure and passes into the cornea. The patient may blink or close the eye during the procedure, which increases patient comfort and aids in maintaining hydration of the cornea. 1. A device for applying light to the eye of the subject comprising:a structure having an inner surface facing in an inward direction and adapted to rest on a surface of the eye so that the inner surface and the surface of the eye define a space, the structure including an optically scattering dome or disc adapted to transmit light to the eye; and a conduit extending from the structure and communicating with the inner surface.2. The device as claimed in claim 1 , further comprising a source of a liquid connected to the conduit.3. The device as claimed in claim 2 , further comprising a pump connected to the source of liquid and the conduit.4. The device as claimed in claim 3 , further comprising a sensor for monitoring liquid in the space between the inner surface of the structure and the surface of the eye claim 3 , and a control circuit connected to the sensor and to the pump for controlling operation of the pump.5. The device as claimed in wherein the pump and the liquid source are operable to supply a fluid containing a photoactive agent so as to fill the space between the eye and the device with the fluid containing the photoactive agent claim 3 , and then to flush the reservoir space with a wetting liquid without the photoactive agent.6. The device as ...

PHOTOACTIVATED MOLECULES FOR LIGHT INDUCED MODULATION OF THE ACTIVITY OF ELECTRICALLY EXCITABLE CELLS AND METHODS OF USING THE SAME

Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. 1. A method of modulating the activity of an electrically excitable cell comprising:placing a photovoltaic compound in close proximity with the electrically excitable cell; and a transition metal complex selected from the group consisting of iron, ruthenium, iridium, osmium, platinum, rhenium, molybdenum, tungsten, platinum, rhodium, and palladium,', 'at least one aryl-containing ligand,', 'at least one hydrophobic molecule covalently attached to the at least one aryl-containing ligand,', 'a first counter ion, and', 'a second counter ion; and, 'exposing the photovoltaic compound to light energy, wherein the photovoltaic compound comprisesinducing an energy and/or electron transfer from the photovoltaic compound to the electrically excitable cell, thereby altering one or more of the transmembrane potential of the electrically excitable cell and the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.2. The method of claim 1 , wherein the first counter ion is an anion.3. The method of claim 1 , wherein the first counter ion is at least one fluoride claim 1 , chloride claim 1 , bromide claim 1 , iodide claim 1 , and hexafluorophosphate.4. The method of claim 1 , wherein the ratio of the first counter ion to the second counter ion is at least one of 4:1 claim 1 , 7:3 claim 1 , 3:2 claim 1 , 3:1 claim 1 , 1:1 claim 1 , 1:3 claim 1 , 2:3 claim 1 , 3:7 claim 1 , 1:4 claim 1 , and 1:9.5. The method of wherein the second counter ion is an anion.6. The method of wherein the second counter ion is at least one of fluoride claim 1 , chloride claim 1 , bromide claim 1 , iodide claim 1 , and hexafluorophosphate.7. The method of claim 1 , wherein at ...

OPHTHALMIC DOCKING SYSTEM WITH 3-DIMENSIONAL AUTOMATIC POSITIONING USING MAGNETIC SENSING ARRAY

A magnetic positioning system and related method for automated or assisted eye-docking in ophthalmic surgery. The system includes a magnetic field sensing system on a laser head and a magnet on a patient interface to be mounted on the patient's eye. The magnetic field sensing system includes four magnetic field sensors located on a horizontal plane for detecting the magnetic field of the magnet, where one pair of sensors are located along the X direction at equal distances from the optical axis of the laser head and another pair are located along the Y direction at equal distances from the optical axis. Based on relative magnitudes of the magnetic field detected by each pair of sensors, the magnetic field sensing system determines whether the patient interface is centered on the optical axis. The system controls the laser head to move toward the patient interface until the latter is centered on the optical axis. 1. An ophthalmic surgical laser system comprising:a laser delivery head, including optics which define an optical axis for delivering a laser beam to an eye of a patient; anda magnetic field sensing system, which includes three or more magnetic field sensors and a control device electrically coupled to the three or more sensors,wherein the three or more sensors are affixed on the laser delivery head and located in a plane perpendicular to the optical axis forming an equal-sided polygon centered at the optical axis, andwherein the control device is configured to control each of the three or more sensors to measure a magnetic field, and based on the measured magnetic field signals by the three or more sensors, to determine whether or not an external magnet that has generated the magnetic field is located within a predetermined distance from the optical axis.2. (canceled)3. The ophthalmic surgical laser system of claim 1 , wherein the predetermined distance is 3 mm.4. (canceled)5. The ophthalmic surgical laser system of claim 1 , wherein the three or more ...

METHOD AND APPARATUS FOR TREATMENT OF OCULAR TISSUE USING COMBINED MODALITIES

A method is provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as peri-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that enables cross-linking (CXL) therapy to be combined with thermal therapy. 1. A method for treating ocular tissue comprising:directing laser radiation in a high absorption range of water to an ocular surface and subsurface region below the ocular surface, wherein the laser radiation modifies the shape of the ocular surface;delivering a cross-linking agent at a depth below the irradiated surface of the ocular tissue at or near the subsurface regions; anddirecting ultraviolet radiation to the ocular surface to promote collagen cross-linking at or near the subsurface region to stabilize the modified shape of the ocular surface, wherein the cross-linking agent promotes the crosslinking.2. The method of claim 1 , wherein the ocular surface is a cornea surface.3. The method of claim 1 , wherein thermal remodeling of the subsurface region induced by the laser radiation modifies the shape of the ocular surface.4. The method of claim 1 , further comprising cooling the ocular surface to prevent thermal remodeling of the surface region and control temperature of the subsurface regions.5. The method of claim 1 , wherein the ultraviolet radiation is delivered in a pulsed and fractionated format to minimize trauma to ocular tissue and to ...

System and method for therapeutic management of ocular hypertension

One embodiment is directed to a method for treating hypertension within the eye of a patient, comprising: delivering an effective amount of polynucleotide comprising an exogenous receptor genetic material which is expressed in a targeted tissue structure of the eye, wherein the targeted tissue structure has been genetically modified to have light sensitive protein; waiting for a period of time to ensure that sufficient portions of the targeted tissue structure of the eye will express the desired light sensitive protein; and causing controlled mechanical changes to the permeability of the eye by directing light to the targeted tissue structure through a light deliver element optically intercoupled between a light source and the targeted tissue structure of the eye.

SYSTEMS AND METHODS FOR DETERMINING CROSS-LINKING DISTRIBUTION IN A CORNEA AND/OR STRUCTURAL CHARACTERISTICS OF A CORNEA

In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth. 1. A measurement system for a cornea , comprising:a light source configured to emit an excitation light that causes a fluorescing agent applied to a cornea to generate a fluorescence emission;at least one optical element positioned to receive the excitation light from the light source and configured to focus the excitation light to an area of corneal tissue at a selected depth of the cornea, the fluorescing agent in the cornea generating the fluorescence emission in response to the excitation light;a pinhole structure including an aperture, the pinhole structure positioned to receive the fluorescence emission from the fluorescing agent in the cornea, the aperture being configured to selectively transmit the fluorescence emission from the area of corneal tissue at the selected depth;a detector positioned to capture the selected fluorescence emission transmitted by the aperture and configured to communicate information relating to a measurement of the selected fluorescence emission captured by the detector; anda controller ...

Dual blade ophthalmologic surgery device

A dual blade device and method useable for performing an ab interno procedure within a human eye to remove a strip of trabecular meshwork tissue.

CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties. 1. A method , comprising:causing absorption of photon energy, absorption of acoustic energy, or a combination thereof, by in vivo corneal stromal tissue of an in situ cornea of an in situ eye, thereby resulting in vitrifying at least 1% of at least one treated volume of the in vivo corneal stromal tissue of the in situ cornea of the in situ eye to produce a composition of matter consisting of a composite of naturally occurring in vivo corneal stromal tissue of the in situ cornea of the in situ eye; and at least one volume of in vivo vitrified corneal stromal tissue of the in situ cornea of the in situ eye;wherein the in vivo corneal stromal tissue in a vitrified state is modified at least in: structure, properties, or any combination thereof, from an in vivo naturally occurring corneal state to an in vivo glass-like state.3. The method of claim 1 , wherein the vitrification is used for at least one of the following:vision,improving vision,compensating for ...

CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties. 1. A light emitting device ,wherein the light emitting device is designed to induce modification of corneal stromal tissue;wherein such device comprises at least one light-emitting source configured in wavelength to cause absorption of photon energy within in vivo stromal tissue of an in situ cornea of an in situ eye, wherein the at least one light-emitting source is one of a laser light-emitting source and a non-laser light-emitting source, andwherein such device is designed to generate a light beam having a sufficient energy and a sufficient duration to produce vitrification of at least 1% of at least one treated volume of stromal tissue of the in situ cornea of the in situ eye;wherein the vitrified corneal stromal tissue is modified in structure and/or properties and/or any combination thereof from a naturally occurring corneal state into a glass-like state;wherein the vitrified corneal stromal tissue occurring in the glass-like state is characterized ...

Surgical device for ab-externo sub-retinal fluid drainage

The present invention provides improved surgical devices for ab-externo sub-retinal fluid drainage and methods for using the same. The surgical devices are illuminated, allow for a reinforced mark to be placed on the sclera, feature a deployable needle, and enable direct visualization of retinal pathology via transillumination of the sclera. The surgical devices allow more precise localization of the site of retinal tears and subretinal fluid drainage.

CROSSLINKING CONTROL

A crosslinking control system, the use of the crosslinking control system, a laser system comprising the crosslinking control system, a crosslinking control method and a method for laser treatment are provided. The crosslinking control system comprises a photosensitizer providing unit, a light source configured to provide light having a wavelength suitable to activate the photosensitizer introduced into or applied onto the tissue for crosslinking, and a control computer. 1. A crosslinking control system comprising:a photosensitizer providing unit configured to provide photosensitizer for introduction or application of the photosensitizer into or onto tissue;a light source configured to provide light having a wavelength suitable to activate the photosensitizer introduced into or applied onto the tissue for crosslinking; anda control computer programmed to determine one or more control parameters for control of at least one of the activation of the photosensitizer and the introduction or application of the photosensitizer.2. The crosslinking control system of claim 1 , wherein the one or more control parameters for control of the activation of the photosensitizer comprise at least one of information specifying the duration of irradiation of the photosensitizer with the light claim 1 , information specifying the intensity of the light for irradiating the photosensitizer claim 1 , information specifying the wavelength of the light for irradiating the photosensitizer claim 1 , information specifying the spatial distribution of the light in or on the tissue claim 1 , and information specifying the temporal distribution of the light in or on the tissue.3. The crosslinking control system of claim 1 , wherein the one or more control parameters for control of the introduction or application of the photosensitizer comprise at least one of information specifying the quantity of the photosensitizer to be introduced or applied into or onto the tissue claim 1 , information ...

CONTROLLED CROSS-LINKING INITIATION AND CORNEAL TOPOGRAPHY FEEDBACK SYSTEMS FOR DIRECTING CROSS-LINKING

Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided. 142-. (canceled)43. A method for treating an eye , comprising:obtaining one or more measurements of an eye of a subject;determining, based on the one or more measurements of the eye, an assessment of an initial shape of a cornea of the eye;determining, based on the assessment, a desired change to the initial shape of the cornea; and applying a cross-linking agent to the cornea; and', 'delivering an initiating element to the cornea,, 'generating the desired change to the initial shape of the cornea, includingwherein the initiating element activates the cross-linking agent to generate cross-linking activity that produces the desired change to the initial shape of the cornea.44. The method of claim 43 , wherein the one or more measurements of the eye include an optical power contour map of the eye claim 43 ,determining the assessment of the initial shape of the cornea includes analyzing optical power at one or more zones of the cornea,determining the desired change to the initial shape of the cornea includes determining changes to the optical power at the one or more zones of the cornea, andthe cross-linking activity produces the changes to the optical power at the ...

SYSTEMS AND METHODS FOR DETERMINING CROSS-LINKING DISTRIBUTION IN A CORNEA AND/OR STRUCTURAL CHARACTERISTICS OF A CORNEA

In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth. 120-. (canceled)21. A measurement system for a cornea , comprising:a light source configured to emit light;at least one optical element positioned to receive the light from the light source and configured to focus the light to an area of corneal tissue at a selected depth of the cornea, a light signal being generated at the area of corneal tissue in response to the light from the light source;a pinhole structure including an aperture, the pinhole structure positioned to receive the light signal generated at the area of corneal tissue, the aperture being configured to selectively transmit the light signal from the area of corneal tissue at the selected depth;a detector positioned to capture the light signal transmitted by the aperture and configured to communicate information relating to a measurement of the light signal captured by the detector; anda controller communicatively coupled to the detector and configured to receive the information from the detector and to determine, based on the information, a measurement of the light ...

Presbyopia Treatment by Lens Alteration

This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and/or by applying energy to affect a change in the accommodative abilities of the human lens. This invention both prevents the onset of presbyopia as well as treats it. By breaking and/or preventing the formation of bonds that adhere lens fibers together causing hardening of the lens, the present invention increases the elasticity and distensibility of the lens and/or lens capsule. 120-. (canceled)21. A method for reversing the effects of presybyopia , comprising:applying an external energy source to a lens of an eye; and administering a reducing agent to the lens to reduce the likelihood of reformation of lenticular disulfide bonds.22. The method of where the energy is of sufficient power to break lenticular disulfide bonds.23. (canceled)24. The method of claim 21 , wherein the energy is any form of electromagnetic radiation.25. The method of claim 21 , wherein the energy is any form of sound energy.26. The method of claim 21 , wherein the energy is any form of heat.27. (canceled)28. The method of claim 21 , wherein the reducing agent is glutathione claim 21 , ascorbic acid claim 21 , a thiol derivative claim 21 , vitamin E claim 21 , tetraethylthiuram disulfyl claim 21 , ophthalmic acid claim 21 , inositol claim 21 , or a beta-carboline.29. The method of claim 21 , further comprising administering to the lens a methylating agent selected from the group consisting of methyl-methane thiosulfonate claim 21 , methyl glutathione claim 21 , S-methyl glutathione claim 21 , S-transferase claim 21 , and other biologically compatible methylating agents claim 21 , wherein the reducing agent is capable of reducing the disulfide bonds into sulfhydryl groups; and wherein the methylating agent is capable of methylating the sulfhydryl groups.30. The method of claim 29 , wherein the ...

DEVICE AND METHOD FOR IRRADIATING THE EYE

A device and a method for irradiating the cornea of an eye, wherein the device comprises at least the following elements: 114-. (canceled)1521: A device for irradiating the cornea () of an eye () , which comprises at least the following elements:{'b': 20', '28', '30', '3', '1, 'a ring body (), which has a bearing surface (, ) embodied concentrically about the longitudinal axis () of the device for the purpose of fastening the device on the eye (),'}{'b': 26', '2', '20, 'an irradiation channel () for irradiating the cornea (), which is located inside the ring body (),'}{'b': 28', '30', '26, 'wherein the bearing surface (, ) for fastening the device is arranged outside the irradiation channel (), wherein the device furthermore comprises'}{'b': 23', '20', '26, 'a UV light source (), which, in the operationally-ready state of the device, is attached inside the ring body () for emitting light in the irradiation channel ().'}1620223423342020: The device according to claim 15 , wherein the ring body () has a receptacle () for a housing () claim 15 , in which the UV light source () is attached claim 15 , wherein in the operationally-ready state of the device claim 15 , each side wall of the housing () claim 15 , if it protrudes distally beyond the ring body () claim 15 , represents an extension of the ring body ().17343233: The device according to claim 16 , wherein the housing () has at least one control electronics system () or a power source ().1823323334: The device according to claim 17 , wherein light source () claim 17 , control electronics () claim 17 , and power source () are enclosed by the shared housing ().193934392234392020: The device according to claim 16 , wherein the device has a housing envelope () claim 16 , which has a stop-limited receptacle for the housing () claim 16 , wherein the housing envelope () itself can be introduced into the receptacle () for a housing claim 16 , preferably in a stop-limited manner claim 16 , and wherein in the operationally- ...

VERSATILE LIGHT-GUIDED OPHTHALMIC TREATMENT SYSTEM

A light-guided, ophthalmic-treatment-system for administering therapeutic agents to, into or through the scleral wall of the eye globe using any one of a variety of therapeutic applicators in conjunction with either transcorneal or transpupillary viewing methods or both. 120-. (canceled)21. A light-guided , ophthalmic-treatment device comprising:an ophthalmic treatment wand having a body made of light transmissive material, said ophthalmic treatment wand having a distal end; anda plurality of emission ports at least partially circumscribing the distal end; wherein said ophthalmic treatment wand is configured to propagate light through the body to the plurality of emission ports.22. The device of claim 21 , further comprising a therapeutic applicator for treating human tissue held at the distal end of the ophthalmic treatment wand.23. The device of claim 22 , wherein the therapeutic applicator is selected from the group consisting of a perforated dispenser claim 22 , medicated-patch applicator claim 22 , treatment-light array claim 22 , and needle array.24. The device of claim 23 , wherein the medicated patch applicator includes an adhesive-patch applicator.25. The device of claim 23 , wherein the needle array includes drug-coated micro-needles or hollow micro-needles.26. The device of claim 21 , wherein the emission ports include luminescent markers selected from the group consisting of photoluminescent markers claim 21 , electroluminescence markers claim 21 , and chemiluminescent markers.27. The device of claim 22 , wherein the ophthalmic treatment wand includes a therapeutic applicator cover.28. The device of claim 27 , wherein the therapeutic applicator cover is configured to be removed from the wand.29. A modular claim 27 , light-guided ophthalmic-treatment-system comprising:an ophthalmic-treatment wand, said wand having a body having a plurality of illumination markers at least partially outlining an interchangeable therapeutic applicator when attached to the ...

SYSTEMS AND METHODS FOR PHOTOACTIVATING A PHOTOSENSITIZER APPLIED TO AN EYE

An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes. 1. A treatment system comprising a wearable photoactivation device including:a body defining a chamber shaped to be positioned over and enclose one or more eyes of a subject, the body including one or more windows that allow the one or more eyes to see through the body;one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters, the illumination parameters determining a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species in the one or more eyes; andan inlet configured to couple the body to an oxygen source, the chamber receiving oxygen from the oxygen source via the inlet to modify oxygen conditions in the chamber, the activation of the photosensitizer depending on the oxygen conditions.2. The treatment system of claim 1 , wherein the one or more photoactivating light sources deliver the photoactivating light as at least one of ...

SEMI-AUTOMATED OPHTHALMIC PHOTOCOAGULATION METHOD AND APPARATUS

An ophthalmic treatment system is configured to perform scanning of target tissue in a patient's eye to at least visualize the target tissue. The scanning pivots about a patient's iris to scan a retina. 1. An ophthalmic treatment system configured to perform scanning of target tissue in a patient's eye to at least visualize the target tissue , wherein the scanning pivots about a patient's iris to scan a retina.2. The ophthalmic treatment system of claim 1 , comprising a light source configured to produce treatment light for performing therapy on the target tissue in a retinal scan field by the scanning that pivots about the patient's iris.3. The ophthalmic treatment system of claim 2 , further comprising a delivery system configured to project a pattern onto the patient's eye claim 2 , the pattern containing a plurality of visible spots that separate from one another claim 2 , whereinin response to a user operation, the delivery system delivers the treatment light to at least two treatment sites that generally match the spots in the patient's eye.4. The ophthalmic treatment system of claim 1 , further comprising a device configured to perform the scanning claim 1 , whereinthe device is an opthalmoscope, a slit lamp biomicroscope, a fundus camera, a scanning laser ophthalmoscope, or an optical coherence tomography system.5. The ophthalmic treatment system of any one of to claim 1 , further comprising:a scanner configured to perform the scanning; andcontrol electronics configured to control at least the scanning by the scanner. The present invention pertains generally to the ophthalmic treatment of a patient's eye, and more particularly to a machine and method for semi-automated ophthalmic photomedical treatment of a patient's eye.Presently, conditions such as diabetic retinopathy, vein occlusion and age-related macular degeneration have been treated with photocoagulation induced by visible laser light. While this type of visible laser light treatment may halt the ...

SURGICAL SYSTEM FOR OPENING THE LENS CAPSULE IN AN EYE

A surgical system for opening the lens capsule in an eye includes an application instrument introducible into the anterior chamber of the eye through an incision in the cornea and/or in the sclera. The application instrument has a contact body that is placeable against the anterior capsular wall of the lens capsule of the eye. Light provided by a light source for generating heat in a contact zone of the capsular wall contacting the contact body is appliable to the contact body. The heat has thermal energy that coagulates the biological tissue in the contact zone. 1. A surgical system for opening the lens capsule in an eye , the surgical system comprising:an application instrument which can be introduced into the anterior chamber of the eye through an incision in at least one of the cornea and sclera;said application instrument including a contact body configured to be placeable upon the anterior capsular wall of the lens capsule of the eye;said contact body and the anterior capsular wall conjointly defining an interface whereat a contact zone of the anterior capsular wall touches said contact body; and,a light source configured for providing light to said contact body to generate heat in said contact zone to apply thermal energy to coagulate the biological tissue in said contact zone.2. The surgical system of claim 1 , wherein said contact body is made of a material which at least partially absorbs said light of said light source.3. The surgical system of claim 2 , wherein said material is stained with a dye.4. The surgical system of claim 3 , wherein said dye is selected from a group including trypan blue or indocyanine green (ICG).5. The surgical system of claim 1 , wherein said contact body is configured to have an annular shape.6. The surgical system of claim 1 , wherein said application instrument includes a cover skin fixed to said contact body; said cover skin is configured to at least partially cover the pupil of the eye and said cover skin has a surface ...

Methods For Treatment Of Dry Eye And Other Acute Or Chronic Inflammatory Processes

Methods for treatment of dry eye and other acute or chronic inflammatory processes are disclosed herein. One method includes administering a drug delivery implant to a patient in need thereof, the drug delivery implant comprising one or more Rock inhibitors and/or one or more Wnt inhibitors, the patient having a medical condition selected from the group consisting of dry eye, lichen planus, arthritis, psoriasis, plantar fasciitis, pars planitis, scleritis, keratitis, chronic meibomian gland inflammation, optic nerve neuritis, uveitis, papillitis, diabetic neural pain, diabetic retinopathy, a cataract, a side effect occurring after refractive surgery, a side effect occurring after corneal transplant, a side effect occurring after retinal detachment surgery, and combinations thereof. The administration of the drug delivery implant to the patient treats the medical condition, reduces the symptoms associated with the medical condition, enhances nerve regeneration, and/or alleviates the medical condition. 1. A method of treating , reducing , or alleviating a medical condition in a patient , said method comprising:administering a drug delivery implant to a patient in need thereof, the drug delivery implant comprising one or more Rock inhibitors and/or one or more Wnt inhibitors, the patient having a medical condition selected from the group consisting of dry eye, lichen planus, arthritis, psoriasis, plantar fasciitis, pars planitis, scleritis, keratitis, chronic meibomian gland inflammation, optic nerve neuritis, uveitis, papillitis, diabetic neural pain, diabetic retinopathy, a cataract, a side effect occurring after refractive surgery, a side effect occurring after corneal transplant, a side effect occurring after retinal detachment surgery, and combinations thereof;wherein the administration of the drug delivery implant to the patient treats the medical condition, reduces the symptoms associated with the medical condition, enhances nerve regeneration, and/or alleviates ...

Minimally Invasive Glaucoma Surgical Instrument and Method

Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal. 1. A device useable for removing trabecular meshwork tissue from the eye of a subject , said device comprising:an elongate probe comprising a probe shaft having a distal end, a hollow inner chamber and an opening near its distal end;a movable cutter disposed within the hollow inner chamber; anda member extending at an angle from the distal end of the probe shaft, said member having a tip, an upper side and a lower side, the opening being located adjacent to the upper side of the member;the probe shaft being insertable into the anterior chamber of the eye and the distal tip of the member being thereafter advanceable through the trabecular meshwork thereby positioning the member in Schlemm's canal with an opposing wall of Schlemm's canal juxtaposed to the lower side of the member and trabecular meshwork tissue juxtaposed to the upper side of the member; andthe moveable cutter being operable to sever trabecular meshwork tissue that passes through the opening.2. A device according to wherein the member is configured so as to be advanceable through Schlemm's canal in a manner that causes trabecular meshwork tissue to ride over the upper side of the member and through the opening.3. A device according to further comprising an aspiration lumen useable for aspirating trabecular meshwork tissue through the opening.4. A device according to further comprising an aspiration pump that is attachable to the aspiration lumen.5. A device according to wherein the moveable cutter rotates.6. A device according to wherein the moveable cutter comprises a rotating cutting head.7. ...

DEUTERON THERAPY

Disclosed is a method of utilizing deuterons (nuclear particles consisting of a proton and a neutron) for charged particle radiotherapy. Compared with proton therapy, at their maximum treatment depth of 66 mm, 125 MeV deuterons possess 82-85% less beam straggling than protons. This difference enables better protection of radiosensitive critical tissues that may be in contact with a tumor. Alternatively, it enables higher doses to be delivered to the tumor, resulting in better tumor control. The implementation of deuteron therapy interchangeably alongside proton therapy requires minor modifications at modest cost to many existing proton therapy systems and provides a clinically useful hybrid particle therapy facility. A free-standing deuteron therapy facility that employs only deuterons is also described. 1. A device , comprising an ion source and an energy selector device , wherein said ion source produces protons and deuterons.2. The device of claim 1 , wherein the ion source is a Penning ionization gauge (PIG).3. The device of claim 1 , wherein the ion source emits deuterons.4. The device of claim 1 , wherein the energy selector device is a pre-absorber.5. The device of claim 4 , wherein the energy selector device comprises two wedges of material configured to move with respect to each other in a way that allows a variable path distance for either a proton or a deuteron beam passing through the pre-absorber.6. The device of claim 1 , wherein the energy selector device comprises graphite or beryllium.7. The device of claim 1 , further comprising a scattering foil.8. The device of claim 7 , wherein the scattering foil comprises lead or nickel.9. The device of claim 1 , further comprising a range modulator wheel.10. The device of claim 1 , further comprising a compensator.11. The device of claim 1 , further comprising a cyclotron.12. The device of claim 11 , wherein the cyclotron is a momentum-bound cyclotron.13. The device of claim 1 , further comprising a ...

OXYGEN ENRICHMENT DURING CORNEAL COLLAGEN CROSSLINKING

Embodiments of the present disclosure relate to methods and apparatus relating to corneal collagen crosslinking (CXL). In some embodiments, disclosed methods and apparatus provide boosted oxygen diffusion into corneal stroma and make possible efficacious accelerated CXL using a non-contact apparatus that reduces use of disposable supplies. In some embodiments, increased atmospheric oxygen concentration around a corneal outer surface occurs, which increases oxygen diffusion into stroma. Accordingly, in some embodiments, increased CXL efficacy occurs as well as reduced overall procedure time. 1. A non-contact corneal collagen crosslinking (CXL) apparatus for increasing stromal oxygen concentration during accelerated CXL by oxygen gas and ultraviolet (UV) light delivery to a corneal surface , the apparatus comprising:a light source to generate the UV light; anda hollow tube coupled to the light source, the hollow tube having an oxygen gas receptacle, an opening, and a lumen, the oxygen gas receptacle configured to receive a supply of the oxygen gas, the opening being located opposite to where the hollow tube is coupled to the light source and configured to confront the corneal surface, and the lumen configured so that the oxygen gas flows toward the opening, the lumen defining a longitudinal axis extending along a propagation path of the UV light for its incidence upon the corneal surface concurrently with the oxygen gas to increase oxygen concentration at the corneal surface to a level exceeding a nominal oxygen concentration.2. The non-contact CXL apparatus of claim 1 , in which the hollow tube includes first and second segments claim 1 , the second segment slidably mounted inside first segment to provide lengthwise adjustment of the hollow tube along the longitudinal axis.3. The non-contact CXL apparatus of claim 2 , in which an upper end of the second segment comprises a lip that is slidable in the first segment.4. The non-contact CXL apparatus of claim 2 , in ...

PHOTOCHEMICALLY INDUCED ENGAGEMENT OF INTRAOCULAR IMPLANTS

An ocular implant and a method for implanting such an ocular implant inside an eye includes an optical portion; and at least two polymer haptics for fixation of the ocular implant to tissue inside an eye. At least one portion of the haptics contains a photoinitiating agent delivery component. A kit for implanting an ocular implant in an eye includes an ocular implant at least two polymer haptics; and additionally a photoinitiating agent for at least partially impregnating a first portion of the ocular element or a second portion of tissue in the eye; and, a light source for providing light of a wavelength adapted to excite the photoinitiating agent. 2. The ocular implant of claim 1 , wherein the photoinitiating agent delivery means comprises an outer surface of the haptics being coated with the photoinitiating agent or comprising an outer layer of the haptics where the photoinitiating agent is embedded.3. The ocular implant of claim 1 , wherein the photoinitiating agent delivery means comprises multiple microfluidic channels through which the photoinitiating agent can flow for delivering the photoinitiating agent in an outer surface of the haptics.4. The ocular implant of claim 1 , which further comprises means for making the implant be in a stretched state.5. The ocular implant of claim 4 , wherein the means for making the implant be in a stretched state comprises at least one tension ring claim 4 , preferably removable.6. The ocular implant of claim 4 , wherein the means for making the implant be in a stretched state comprises at least one balloon.7. The ocular implant of claim 1 , which further comprises a plurality of light guiding elements.8. The ocular implant of claim 7 , wherein the light guiding elements are embedded in a tension ring or a balloon.9. A kit for implanting an ocular implant in an eye claim 7 , the kit comprising:the ocular implant comprising at least two polymer haptics;a photoinitiating agent for at least partially impregnating a first ...

APPARATUS FOR PHOTOTHERAPY OF THE EYE

A device and method for applying light to the cornea of the eye as, for example, to promote crosslinking of collagen in the cornea for vision correction. The device may include a structure having form and size similar to a conventional contact lens. The structure may include an optically dispersive element such as a mass of an optically dispersive material that may be contained in a cavity of a reflective element. Light applied to the dispersive mass as, for example, by an optical fiber connected to the structure is dispersed in the structure and passes into the cornea. The patient may blink or close the eye during the procedure, which increases patient comfort and aids in maintaining hydration of the cornea. 1. A method of applying light to the eye of a subject comprising directing light in a direction generally parallel to the surface of the cornea of the eye within an optically dispersive element overlying the surface of the cornea so that light dispersed by the element passes out of the element and into the cornea.2. A method as claimed in wherein the step of directing light includes directing light along the lengthwise direction of a dispersive optical fiber overlying a surface of the eye.3. A method as claimed in wherein claim 2 , during the step of directing light claim 2 , the fiber is disposed in a loop.4. A method as claimed in wherein the loop is substantially circular and encircles the optic axis of the eye.5. A method as claimed in wherein at least some of the light passing out of the fiber along its length passes into an optically dispersive mass overlying the cornea claim 3 , and wherein light dispersed in the mass passes into the cornea.6. A method as claimed in wherein the light passing out of the dispersive element irradiates the cornea and crosslinks the cornea.7. A method as claimed in further comprising applying a crosslinking agent to the cornea so that the crosslinking agent is present in the cornea during the step of directing light.8. A ...

DUAL BLADE OPHTHALMOLOGIC SURGERY DEVICE

Methods and devices for cutting strips of tissue from masses of tissue inside or outside of the bodies of human or animal subjects. The device generally comprises a) an elongate cutting tube that has a distal end and a lumen that opens through an opening in the distal end and b) first and second cutting edges formed on generally opposite edges of the distal end of the cutting tube and separated by a distance D. The device is advanced through tissue to cut a strip of tissue of approximate width W. Width W is approximately equal to distance D. 1. A device useable for forming an opening in trabecular meshwork of a subject's eye , said device comprising:a proximal portion sized to be grasped by a hand of a human operator;an elongate probe that extends from the proximal portion, said elongate probe having a shaft, a distal protruding tip and first and second cutting edges;the distal protruding tip having a top side, a bottom side and a terminal end;the distal protruding tip extending from a distal end of the haft to form a bend or curve;the distal protruding tip being wider at its junction with the shaft than at its terminal end;the first and second cutting edges comprising first and second fixed blades at spaced-apart positions on lateral sides of the shaft adjacent to the top side of the distal protruding tip;the shaft, distal protruding tip and first and second fixed blades being sized so that the probe is;a) insertable into an anterior chamber of a subject's eye,b) advanceable through the anterior chamber to a location where the distal protruding tip is in contact with trabecular meshwork tissue which overlies Schlemm's Canal of the subject's eye,c) moveable in a manner that causes the terminal end of the distal protruding tip to penetrate through the trabecular meshwork tissue and causes the distal protruding tip to become positioned within Schlemm's Canal under the trabecular meshwork tissue, such that the trabecular meshwork tissue extends over the upper side of ...