11-06-2020 дата публикации
Номер: US20200179268A1
Принадлежит:
An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia. 1. An aqueous oral gel composition for the treatment of oral leukoplakia comprising a nonsteroidal anti-inflammatory drug (NSAID) or a pharmaceutically acceptable salt thereof , hyaluronic acid or a pharmaceutically acceptable salt thereof , a gelling agent or thickener , and a flavoring agent and/or sweetener.2. The oral gel composition of claim 1 , wherein the NSAID is selected from the group consisting of: aspirin claim 1 , celecoxib claim 1 , diclofenac claim 1 , diflunisal claim 1 , etodolac claim 1 , ibuprofen claim 1 , indomethacin claim 1 , ketoprofen claim 1 , ketorolac claim 1 , nabumetone claim 1 , naproxen claim 1 , oxaprozin claim 1 , piroxicam claim 1 , salsalate claim 1 , sulindac claim 1 , and tolmetin.3. The oral gel composition of claim 2 , which comprises a combination of diclofenac or a pharmaceutically acceptable salt thereof in an amount of about 0.1% to about 15% w/w and hyaluronic acid or a pharmaceutically acceptable salt thereof in the amount of about 0.1% to about 10% w/w.4. The oral gel composition of claim 2 , which comprises a combination of diclofenac or a pharmaceutically acceptable salt thereof in an amount of about 0.5% to about 6% w/w and hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount of about 1% to 6.0% w/w.5. The oral gel composition of claim 4 , wherein the gelling agent or thickener is selected from the group consisting of hectorite claim 4 , carboxyvinyl polymers claim 4 , poloxamers claim 4 , Irish moss claim 4 , i-carrageenan claim 4 , gum tragacanth claim 4 , starch claim 4 , polyvinyl alcohol (PVA) claim 4 , polyvinylpyrrolidone claim 4 , hydroxyethylpropyl-cellulose claim 4 , hydroxybutyl ...
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