19-05-2016 дата публикации
Номер: US20160136288A1
Принадлежит:
The application relates to an immunogenic composition comprising a continuous aqueous phase and at least two dispersed phases 1 and 2 as droplets, wherein the dispersed phase 1 comprises a surfactant 1 bearing an antigen and the dispersed phase 2 comprises an immunostimulating agent 2, to its preparation method and its uses, notably for producing antibodies, as a drug, as a vaccine or in an immunization method. 1. An immunogenic composition comprising a continuous aqueous phase and at least two dispersed phases 1 and 2 as droplets wherein: an amphiphilic lipid 1,', 'a solubilizing lipid 1 comprising at least one fatty acid glyceride,', 'a co-surfactant 1 comprising at least one chain consisting of alkylene oxide units,', {'br': None, 'sub': 1', '1', '1', '1', 'v', '1, '(L-X-H-Y)-G-Z-Ag \u2003\u2003(I),'}, 'a surfactant 1 bearing an antigen of the following formula (I)], 'the dispersed phase 1 comprises [{'sub': '1', 'Lrepresents a lipophilic group,'}, {'sub': 1', '1', '1, 'X, Y, Zand G represent independently a binding group,'}, {'sub': '1', 'Hrepresents a hydrophilic group comprising a polyalkoxylated chain,'}, 'v is an integer from 1 to 8, and', 'Ag represents an antigen,, 'whereinwherein the molar ratio of the surfactant 1 bearing an antigen of formula (I) over the sum of the co-surfactant 1 and of the surfactant 1 bearing an antigen of formula (I) is from 0.01% to 5%, and an amphiphilic lipid 2,', 'a solubilizing lipid 2 comprising at least one fatty acid glyceride,', 'a co-surfactant 2 comprising at least one chain consisting of alkylene oxide units,', 'an immunostimulating agent 2,, 'the dispersed phase 2 compriseswith the proviso that the dispersed phase 2 is free of surfactant bearing an antigen of formula (I).5. The immunogenic composition according to claim 1 , wherein:the amphiphilic lipid 1 and/or the amphiphilic lipid 2 is(are) a phospholipid, and/or{'sub': 12', '14', '16, 'the solubilizing lipid 1 and/or the solubilizing lipid 2 consist(s) of a mixture ...
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