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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 3687. Отображено 100.
08-11-2012 дата публикации

Composition and method thereof

Номер: US20120282332A1
Автор: Mohan Vishwaraman, Sunil Bhaskaran
Принадлежит: Indus Biotech Pvt Ltd

The present disclosure relates to a composition comprising Trigoneoside Ib and Vicenin-1 for treatment and management of Goodpasture's disease, Glomerulonephritis, Rheumatoid Arthritis, Systemic Lupus Erythematosus and Idiopathic Thrombocytopenia Purpura. The present disclosure also relates to a method of obtaining the said composition from Trigonella foenum - graecum.

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Номер записи: 1
10-01-2013 дата публикации

Ginger Extract for Inhibiting the Fat-storage Function of Adipocytes and a Medication thereof

Номер: US20130011500A1
Автор: Chia-Ju Chang, I-Min Liu, Shorong-Shii Liou
Принадлежит: Han Sheng Pharmtech Inc

In the present invention, a ginger extract for inhibiting the fat-storage function of adipocytes and a medication thereof is disclosed, wherein the ginger extract is obtained form Alpinia galangal and Zingiber zerumbet.

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Номер записи: 2
28-03-2013 дата публикации

Method and Composition for Administering Bioactive Compounds Derived From Morinda Citrifolia

Номер: US20130079380A1
Автор: Afa K. Palu, Bing-Nan Zhou, Brett J. West, Chen Su, Claude Jarakae Jensen, Shixin Deng, Stephen Story
Принадлежит: MORINDA HOLDINGS Inc

This invention relates to a method and composition for providing in various health benefits by administering various bioactive compounds derived from the plant Morinda cirtrifolia to individuals. This invention relates to using one or more of the following: Noni Leaf Extract; Noni Leaf Juice; and/or Roast Leaf More particularly this invention relates to administering one or more of the following: Pyro-phorbide a, Pheophorbide a, Purpin 7, and/or Pheophorbide all which may be derived from Noni leaf extract, Noni leaf juice, and/or Roast leaf Moreover, the foregoing formulations result in alleviating pain and inflammation.

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Номер записи: 3
04-04-2013 дата публикации

Process of preparing burdock composite micron essence

Номер: US20130084380A1
Автор: Hsueh-Chiao Liu, Tong-Rong Tsai
Принадлежит: DONG YUAN BIOTECH PHARMACEUTICAL CO Ltd

A process of preparing a burdock composite micron essence at least includes the following. Dissolved and heated phospholipid is added to a vegetable oil extract and then stirred. After stirring, the above mixture is pour into a heated glycerol and then further stirred and a burdock extract aqueous solution is added. The aforementioned mixed solution is stirred at high speed, the emulsion-homogenized solution is subject to high-pressure homogenization, and a filtration membrane is used to filter the homogenized solution obtained to get a purple transparent burdock concentrate. The burdock concentrate is used to prepare the formulation of nano-micro emulsion which is easily absorbed by human body and thus grants improved health benefits.

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Номер записи: 4
14-11-2013 дата публикации

Method for Preparing Pharmaceutical Composition for Enhancing Immunity and Pharmaceutical Composition Prepared According to the Method

Номер: US20130302379A1
Автор: Chunsheng Guo, Dejun Sun, Jinlong Yin, Miaonan Sun, Xue Li, Yanhui Gao, Yizhuo Zhao
Принадлежит: Jilin Zixin Pharmaceutical Res Inst LLC

A method for preparing a pharmaceutical composition for enhancing immunity and a pharmaceutical composition prepared according to the method. The method includes steps of: mixing ginseng ethanol extract with fruit and vegetable fermentation conversion solution to obtain a mixture, namely, the pharmaceutical composition for enhancing immunity; wherein the ginseng ethanol extract is prepared by a following step of: reflux extracting ginseng by ethanol aqueous solution for obtaining the extract, namely, the ginseng ethanol extract; the fruit and vegetable fermentation conversion solution is prepared by following steps of: mixing fruit and vegetable, lactobacillus acidophilus bacteria solution, bifidobactreium longum bacteria solution, lactobacillus delbrueckiisubsp. bulgaricus bacteria solution, streptococcus thermophilus bacteria solution with water, and then fermenting for obtaining a fermentation product, namely, the fruit and vegetable fermentation conversion solution.

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Номер записи: 5
28-11-2013 дата публикации

Whitening agent, anti-aging agent, and antioxidant agent

Номер: US20130315850A1
Автор: Ken Kusakari, Kiyoshi Sato, Kiyotaka Hasegawa, Rikako Suzuki, Tokiya Yokoi
Принадлежит: Shiseido Co Ltd

The present invention is directed to an extrace of Psilotum spp., as a skin whitening agent. Whitening agents according to the invention exhibit superior effects, for example, by lightening and whitening skin pigmentation, lightening and whitening aging spots, freckles, chloasma, or the like after sunburn. The Psilotum spp. extract of the invention has a superior free radical scavenging ability permitting the extract to control skin aging and skin diseases caused by active oxygen (free radicals), while having a high level of safety.

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Номер записи: 6
30-01-2014 дата публикации

Antiviral compositions comprising ethanol extract of tetracera scandens and use thereof

Номер: US20140030364A1
Автор: Ji Chang You
Принадлежит: Industry Academic Cooperation Foundation of Catholic University of Korea

A composition for preventing or treating a viral infection, which includes an ethanol extract of Tetracera scandens as an effective component, is provided. The composition exhibits low toxicity and few side effects and effectively inhibits reverse transcriptase activities to suppress synthesis of DNA, and thus can be useful in preventing or treating infections caused by various kinds of RNA viruses.

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Номер записи: 7
06-01-2022 дата публикации

Composition comprising elderberry extract as effective component for preventing, treating, or alleviating andropause syndrome

Номер: US20220000954A1
Автор: Hyun Seok Kong
Принадлежит: Kosa Bio Inc

The present invention relates to a composition comprising an elderberry extract as an effective component for preventing, treating, or alleviating andropause syndrome, wherein the elderberry extract of the present invention increases testosterone secretion in sperm cells and andropause syndrome animal models, and thus can be usefully employed as a pharmaceutical or food composition for preventing, treating or alleviating andropause syndrome.

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Номер записи: 8
07-01-2016 дата публикации

Herbal composition and a method of treating uterine fibroids

Номер: US20160000846A1
Автор: Chia-Ru Chang, I-Min Liu, Shih-Chiang Lee, Shorong-Shii Liou
Принадлежит: Kang Li Biotech Co Ltd

The invention discloses an herbal composition of treating uterine fibroid. The herbal composition comprises Antrodia cinnamomea, Astragalus membranaceus , and Leonurus japonicus ; wherein the weight percentages of Antrodia cinnamomea, Astragalus membranaceus and Leonurus japonicus are 25 to 75%, 20.8 to 62.5% and 4.2 to 12.5% by weight of the formula, respectively. The invention also discloses a method of treating uterine fibroid.

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Номер записи: 9
14-01-2016 дата публикации

Plant and Animal Extracts and Related Methods

Номер: US20160008417A1
Автор: Christopher VANDECAR
Принадлежит: Individual

The present disclosure is drawn to methods for producing natural extracts utilizing fulvic acid solutions as well as the extracts produced utilizing the disclosed methods. The method provides for selecting natural material(s) for extraction and contacting the natural material with a fulvic acid solution. In some embodiments the contacting can occur by pouring, dripping, sprinkling, submersing, or substantially submersing the natural material with the fulvic acid solution.

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Номер записи: 10
14-01-2021 дата публикации

Compositions and methods for treating diarrheal diseases

Номер: US20210008028A1
Автор: Adrian Subia SAINZ, Dmitry Kravtsov, Ludmila I. KVOCHINA, Norman Gray
Принадлежит: Vanessa Research Inc

Provided is a composition for the treatment of diarrheal disease, comprising a polyphenol-rich extract of a mixture of 80-20% by weight of blueberry or bilberry from Vaccinium cyanococcus spp., Vaccinium myrtillis spp., or both; and 20-80% by weight of sloe berry from Prunus spinosa spp. Other compositions, and methods of making and using the compositions for the treatment of diarrheal disease are disclosed.

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Номер записи: 11
11-01-2018 дата публикации

METHOD FOR PRODUCING A COMPLEX OF BIOLOGICALLY ACTIVE SUBSTANCES EXHIBITING HYPOGLYCEMIC ACTIVITY

Номер: US20180008658A1
Автор: KUTSANYAN Akop Surikovych, LYTVYNENKO Vasyl Ivanovych
Принадлежит:

The invention relates to medicine and chemical and pharmaceutical industry, in particular, to methods for producing a complex of biologically active substances exhibiting hypoglycaemic activity of plant material. A method for producing a complex of biologically active substances exhibiting hypoglycaemic activity comprises extracting bean herb with alcohol followed by concentrating and/or drying the extract, wherein the extraction is carried out with 96% alcohol resulting in a first extract and a bean herb residue, wherein the first extract is concentrated resulting in a first solid extract or it is concentrated and dried resulting in a first dry extract and the bean herb residue is extracted with 70% alcohol resulting in a second extract at least a portion of which being concentrated resulting in a second solid extract or being concentrated and dried resulting in a second dry extract. 1. A method for producing a complex of biologically active substances exhibiting hypoglycaemic activity , comprisingextracting bean herb with alcohol followed by concentrating and/or drying the extract,characterized in that the extraction is carried out with 96% alcohol resulting in a first extract and a bean herb residue, whereinthe first extract is concentrated resulting in a first solid extract orit is concentrated and dried resulting in a first dry extract,and the bean herb residue is extracted with 70% alcohol resulting in a second extract at least a portion of which being concentrated resulting in a second solid extract orbeing concentrated and dried resulting in a second dry extract.2. The method of claim 1 , characterized in that the bean herb is fine cut prior to the extraction.3. The method of claim 2 , characterized in that the bean herb is fine cut by rolling into particles sized up to 1 mm.4. The method of claim 1 , characterized in that at least a portion of the second extract is used as one of the target products.5. The method of claim 1 , characterized in that 96% ...

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Номер записи: 12
27-01-2022 дата публикации

Isolation and characterization of anticancer compound from sesuvium portulacastrum (l.) l.

Номер: US20220024872A1
Автор: Lakshmi Narasu Mangamoori, Sathvika CHINTALAPANI
Принадлежит: Individual

The invention discloses a novel anticancer compound, 3, 4, 5-trimethyl-2-(4-(8-methylnonyl)phenyl)pyridine extracted from Sesuvium portulacastrum (S. portulacastrum) having the structure as represented by Formula (I). The invention also discloses a method of extraction of this anticancer compound, 3, 4, 5-trimethyl-2-(4-(8-methylnonyl)phenyl)pyridine from S. portulacastrum. The invention further relates to characterization of the anticancer compound, 3, 4, 5-trimethyl-2-(4-(8-methylnonyl)phenyl)pyridine and study of its effect on the cancer cell cycle progression and expression of genes involved in apoptosis.

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Номер записи: 13
03-02-2022 дата публикации

CANNABIS OIL EXTRACTS AND COMPOSITIONS

Номер: US20220031781A1
Автор: Bestwick Haley Poole, Finley Constance, McKee Luke, Roethle Paul
Принадлежит: Constance Therapeutics, Inc.

The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition. 127-. (canceled)28. A formulation comprising a cannabis oil extract , α-tocopherol , one or more essential oils , and one or more carrier oils.29. The formulation of claim 28 , wherein the carrier oils are selected from the group consisting of almond oil claim 28 , aloe vera oil claim 28 , apricot kernel oil claim 28 , avocado oil claim 28 , argan oil claim 28 , calendula oil claim 28 , carrot seed oil claim 28 , castor oil claim 28 , coconut oil claim 28 , evening primrose oil claim 28 , fish oil claim 28 , algae oil claim 28 , krill oil claim 28 , flaxseed oil claim 28 , grape seed oil claim 28 , hazelnut oil claim 28 , hemp seed oil claim 28 , jojoba oil claim 28 , macadamia oil claim 28 , olive oil claim 28 , raspberry seed oil claim 28 , sesame oil claim 28 , sunflower oil claim 28 , walnut oil claim 28 , and wheatgerm oil.30. The formulation of claim 28 , wherein the essential oils are selected from the group consisting of bergamot essential oil claim 28 , blood orange essential oil claim 28 , calendula essential oil claim 28 , helichrysum essential oil claim 28 , lavender essential oil claim 28 , lemon essential oil claim 28 , lemongrass essential oil claim 28 , neroli essential oil claim 28 ...

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Номер записи: 14
18-01-2018 дата публикации

Vaporized Medicants and Methods of Use

Номер: US20180015034A1
Автор: Alexander ChinHak Chong, Marshall A. Thompson, William P. Bartkowski
Принадлежит: Chong Corp

A method and formulation for delivering an active analgesic compound, such as an opiate, in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the active compound. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer.

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Номер записи: 15
28-01-2016 дата публикации

Method for preparing pharmaceutical compositions of rhizomes from alpinia galanga or alpinia conchigera having a high content of 1's-1'-acetoxychavicol acetate (aca)

Номер: US20160022756A1
Автор: Henrik Byrial JAKOBSEN, Ina GIVERSEN
Принадлежит: NERTHUS APS

The present invention relates to a method for preparing a granulate composition of rhizomes from Alpinia galanga or Alpinia conchigera having a high and stable content of 1′S-1′-acetoxychavicol acetate and low microbiological count, which is suitable for preparing orally ingestible dosage forms such as tablets or capsules.

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Номер записи: 16
26-01-2017 дата публикации

Cordyceps containing topical skin care formulation

Номер: US20170020805A1
Автор: Aaron Ballantyne, Dale Kern, Deanna Carter, Helen Knaggs, Jin NAMKOONG, Remona Gopaul
Принадлежит: NSE Products Inc

The present disclosure relates to extracts of Cordyceps spp., topical formulations containing extracts of Cordyceps spp., methods of formulating the extract and formulations, and methods of use. In one embodiment the Cordyceps spp. is Cordyceps sinensis.

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Номер записи: 17
26-01-2017 дата публикации

SINGLE SERVE BEVERAGE POD CONTAINING CANNABIS

Номер: US20170020814A1
Автор: BENSON Ronald Stuart, GEMMITI Claudio, HOBBES Peter, PLATT IIana Deborah
Принадлежит:

Single-serve containers for use in brewing a cannabis-based beverage are described, as are methods for preparing a single-serve container configured for receipt in a single-serve brewing machine. The method includes: adding a processed cannabis product to the single-serve container; adding, to the single-serve container, at least one of an extraction or flavoring agent; and sealing the single-serve container. 1. A method of preparing a packaged beverage product , the method comprising:processing cannabis by heating the cannabis to decarboxylate the cannabis;adding the processed cannabis to the packaged beverage product;adding, to the packaged beverage product, an effective amount of a lipid-rich food-based extraction agent, wherein the extraction agent is a powder and is solid at room temperature; andsealing the packaged beverage product.2. The method of claim 1 , wherein the extraction agent is selected from the group consisting of milk powder claim 1 , powdered dairy creamer claim 1 , powdered non-dairy creamer claim 1 , cocoa powder claim 1 , chocolate powder claim 1 , powdered coconut flakes claim 1 , coconut flour claim 1 , flax meal powder claim 1 , quinoa flour claim 1 , and almond flour.3. The method of claim 1 , further comprising claim 1 , prior to sealing:adding, to the packaged beverage product, a flavoring agent.4. The method of claim 3 , wherein the flavoring agent is selected from the group consisting of:tea, coffee or chocolate, latte or cappuccino.5. The method of claim 1 , further comprising:pulverizing the cannabis.6. The method of claim 5 , wherein pulverizing comprises pulverizing the cannabis to a particle size of 2 millimeters or less.7. The method of claim 5 , wherein pulverizing comprises pulverizing the cannabis to a particle size of 1 millimeter or less.8. The method of claim 5 , further comprising claim 5 , after pulverizing claim 5 , filtering the pulverized cannabis to separate cannabis having a desired particle size.9. The method of ...

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Номер записи: 18
24-01-2019 дата публикации

Fruit or Vegetable Pomace Composition and Use as Blood Glucose Modulator and Anti-Diabetic Agent

Номер: US20190022160A1
Автор: HAYES Kenneth C., Perlman Daniel
Принадлежит:

Methods of improving mammalian carbohydrate metabolism and treating, preventing, or halting the progression of type 2 diabetes mellitus involve the consumption of a nutritional composition containing fruit or vegetable pomace. The pomace is produced from native plant tissue and contains a mixture of soluble and insoluble fiber. Periodic consumption of the composition normalizes blood glucose concentration and controls body weight. 1. A method of maintaining or achieving normal blood glucose concentration in response to a diabetogenic diet in a mammalian subject , the method comprising periodically administering to a mammalian subject consuming a diabetogenic diet a nutritional composition comprising sugar-reduced carrot pomace , whereby the subject's blood glucose concentration is maintained within a normal range or achieves a value within a normal range.2. The method of claim 1 , wherein said carrot pomace provides at least 20% of the recommended daily intake of dietary fiber for the subject.3. The method of claim 1 , wherein said diabetogenic diet provides at least 40% of the subject's dietary energy in the form of carbohydrate.4. The method of claim 1 , wherein the carrot pomace comprises a mixture of soluble fiber and insoluble fiber.57.-. (canceled)8. The method of claim 1 , wherein the carrot pomace is produced from carrots by a method comprising heat treatment claim 1 , juice extraction claim 1 , drying claim 1 , and grinding.9. The method of claim 8 , wherein the carrot pomace is produced by a method comprising heat treatment sufficient to raise the carrot tissue to a temperature in the range from about 120° F. to about 200° F.10. The method of claim 8 , wherein the carrot pomace is produced by a method comprising release of at least 40% of the carrot weight as juice claim 8 , the juice containing at least 3.5 wt % sugar.11. (canceled)12. The method of claim 1 , wherein said maintaining normal blood glucose is determined using a random blood glucose test ...

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Номер записи: 19
28-01-2021 дата публикации

BIOACTIVE CONCENTRATES AND USES THEREOF

Номер: US20210023156A1
Автор: Wurzer Joshua H.
Принадлежит:

The present invention relates to concentrates obtained from extraction from , preferably cannabinoid and/or terpene concentrates, and formulation of the concentrates, particularly for use for direct vaporization, infusion into edible matrices, in electronic inhalation devices, and as nutraceuticals. 1. An oral delivery vehicle consisting essentially of at least 1% w/w each in the total tablet or total capsule of at least two cannabinoids selected from the group consisting of Cannabigerolic acid A (Z)-CBGA-CA , Cannabichromenic acid A CBCA-CA , and Cannabinol CBN-C , said oral delivery vehicle selected from the group consisting of a chewable matrix and a polymeric thin film.2. The oral delivery vehicle of claim 1 , wherein said chewable matrix is a chewing gum.3. The oral delivery vehicle of claim 1 , wherein said oral delivery vehicle consists essentially of at least 1% w/w each in the total oral delivery vehicle of said Cannabigerolic acid A (Z)-CBGA-CA claim 1 , Cannabichromenic acid A CBCA-CA claim 1 , and Cannabinol CBN-C.4. The oral delivery vehicle of claim 1 , further comprising at least 0.1% w/w each in the total oral delivery vehicle of at least one terpenoid selected from the group consisting of Alloaromadendrene claim 1 , allyl hexanoate claim 1 , benzaldehyde claim 1 , (Z)-a-cis-bergamotene claim 1 , (Z)-a-trans-bergamotene claim 1 , beta-bisabolol claim 1 , epi-alpha-bisabolol claim 1 , beta-bisabolene claim 1 , borneol claim 1 , c-gamma-bisabolene claim 1 , borneol acetate claim 1 , alpha-cadinene claim 1 , camphene claim 1 , camphor claim 1 , cis-carveol claim 1 , caryophyllene claim 1 , alpha-humulene claim 1 , gamma-cadinene claim 1 , delta-3-carene claim 1 , caryophyllene oxide claim 1 , 1 claim 1 ,8-cineole claim 1 , citral A claim 1 , citral B claim 1 , cinnameldehyde claim 1 , alpha-copaene claim 1 , gamma-curcumene claim 1 , beta-cymene claim 1 , beta-elemene claim 1 , gamma-elemene claim 1 , ethyl decdienoate claim 1 , ethyl maltol claim 1 , ...

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Номер записи: 20
28-01-2021 дата публикации

STEROL DERIVATIVES AND PREPARATION METHOD AND USES THEREOF

Номер: US20210024570A1
Автор: Duan Zhenwen, Guo Shuren, Li Xuemei
Принадлежит:

The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, Ris selected from the group consisting of —OH, ═O(carbonyl), H, and C-Calkyl; Ris selected from the group consisting of —OH, H, and C-Calkyl; Ris selected from the group consisting of —OH, ═O, H, and C-Calkyl; Ris selected from the group consisting of —OH, H, and C-Calkyl; and none, one, two, three or four of R, R, R, and Rare —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight. 2. The pharmaceutical composition of claim 1 , wherein said ester of the compound of Formula (II) is selected from the group consisting of formate claim 1 , acetate claim 1 , propionate claim 1 , p-tolylsulfonate and trifluoromethylsulfonate; and wherein said ether is tert-butyl-dimethyl silyl ether.3. The pharmaceutical composition of claim 1 , wherein said ester or ether is tetraacetate of compound of Formula II claim 1 , tetra-p-tolylsulfonate of compound of Formula II claim 1 , tetra(trifluoromethylsulfonate) of compound of Formula II claim 1 , or tetra(tert-butyl-dimethyl-silyl ether) of compound of Formula II.4Monascus. The pharmaceutical composition of wherein the compound of Formula (II) is extracted from -fermented rice.5Monascus. The pharmaceutical composition of wherein the compound of Formula (II) is isolated from an alcohol extract of -fermented rice.7. The pharmaceutical composition of further comprising a pharmaceutically acceptable carrier or excipient. This application is a continuation application of U.S. patent application Ser. No. 14/368,494, filed Jun. 24, 2014 (now allowed), which is a 371 national stage application of International Patent ...

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Номер записи: 21
01-02-2018 дата публикации

Composition comprising an onion extract and liposomes

Номер: US20180028587A1
Автор: Martina Heberer, Peter Boderke, Petra Scheppler
Принадлежит: Merz Pharma GmbH and Co KGaA

The present invention relates to a composition comprising a first onion extract (A), and liposomes, wherein at least a portion of the onion extract is encapsulated in the liposomes. Furthermore the present invention relates to a method for preparing a composition comprising a first onion extract (A), and liposomes, wherein at least a portion of the onion extract is encapsulated in the liposomes. Further, the present invention relates to a composition comprising an onion extract (A) ( Allium cepa ) and liposomes, obtainable by or obtained by the method. Furthermore, the present invention relates to compositions comprising a first onion extract (A), and liposomes, wherein at least a portion of the onion extract is encapsulated in the liposomes, for use in treating and/or preventing scars.

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Номер записи: 22
29-01-2015 дата публикации

Sterols derivative, and preparation method and purpose thereof

Номер: US20150031657A1
Автор: Shuren Guo, Xuemei Li, Zhenwen Duan
Принадлежит: Beijing Peking University WBL Biotech Co Ltd

The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R 1 is selected from the group consisting of —OH, ═O(carbonyl), H, and C 1 -C 3 alkyl; R 2 is selected from the group consisting of —OH, H, and C 1 -C 3 alkyl; R 3 is selected from the group consisting of —OH, ═O, H, and C 1 -C 3 alkyl; R 4 is selected from the group consisting of —OH, H, and C 1 -C 3 alkyl; and none, one, two, three or four of R 1 , R 2 , R 3 , and R 4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.

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Номер записи: 23
17-02-2022 дата публикации

Compositions that contain lipophilic plant material and surfactant, and related methods

Номер: US20220047965A1
Автор: Michael J. Turcotte, Michael V. Zumpano
Принадлежит: Individual

Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

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Номер записи: 24
30-01-2020 дата публикации

Method and apparatus for harvesting trichomes from cannabis plants

Номер: US20200030397A1
Автор: Andrew Vincent SHLANTA, Eric Charles BENDER, Mark Wayne LANHAM, Michael Robert Himes
Принадлежит: Air Products and Chemicals Inc

A method of harvesting trichomes from a cannabis plant piece containing one or more trichomes attached to biomass material, the biomass material including one or more of stalk material, flower material, and leaf material, including freezing a cannabis plant piece by exposing the plant piece to a cryogenic fluid to create a frozen plant piece; processing the frozen plant piece to separate the trichomes from the biomass material using one or more screens; removing the biomass that has been prevented from passing through the one or more screens; and collecting the trichomes that have passed through the one or more screens.

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Номер записи: 25
30-01-2020 дата публикации

STEVIA COMPOSITION, PRODUCTION METHOD AND USES

Номер: US20200032358A9
Автор: MARKOSYAN Avetik
Принадлежит:

compositions are prepared from Bertoni extracts. The compositions are able to provide a superior taste profile and can be used as sweeteners, sweetness enhancers, flavors, flavor enhancers in foods, beverages, cosmetics and pharmaceuticals. 1. A process for producing a steviol glycosides composition , comprising the steps of:providing a solution containing at least two glycosides of steviol;providing at least one resin capable of adsorbing steviol glycosides;contacting the resin with solution containing at least two glycosides of steviol to obtain a resin with at least one steviol glycoside adsorbed onto resin;eluting the resin to obtain a steviol glycosides composition comprising at least one steviol glycoside.2steviaStevia rebaudiana. A sweetener composition comprising steviol glycosides composition made by the process of claim 1 , and an additional sweetening agent selected from the group consisting of: extract claim 1 , steviol glycosides claim 1 , stevioside claim 1 , rebaudioside A claim 1 , rebaudioside B claim 1 , rebaudioside C claim 1 , rebaudioside D claim 1 , rebaudioside E claim 1 , rebaudioside F claim 1 , rebaudioside M claim 1 , rebaudioside N claim 1 , rebaudioside O claim 1 , dulcoside A claim 1 , steviolbioside claim 1 , rubusoside claim 1 , other steviol glycosides found in Bertoni plant and mixtures thereof claim 1 , glycosylated steviol glycosides claim 1 , Luo Han Guo extract claim 1 , mogrosides claim 1 , glycosylated mogrosides claim 1 , high-fructose corn syrup claim 1 , corn syrup claim 1 , invert sugar claim 1 , fructooligosaccharides claim 1 , inulin claim 1 , inulooligosaccharides claim 1 , coupling sugar claim 1 , maltooligosaccharides claim 1 , maltodextins claim 1 , corn syrup solids claim 1 , glucose claim 1 , maltose claim 1 , sucrose claim 1 , lactose claim 1 , aspartame claim 1 , saccharin claim 1 , sucralose claim 1 , sugar alcohols claim 1 , and a combination thereof.3. A flavor composition comprising a steviol glycosides ...

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Номер записи: 26
08-02-2018 дата публикации

Compositions And Methods Comprising Yeast Organisms And Lipid Extracts Thereof

Номер: US20180036225A1
Автор: Maria Corena McLeod, Ramon F. Figueroa, Zvi G. Loewy
Принадлежит: Rf Technology Consultants Inc

Disclosed herein are methods and compositions comprising whole yeast organisms and/or lipid yeast extract. Such compositions may be cosmetic, medical, biotechnological or agricultural compositions, comprising one or more cosmetic, medical, biotechnological or agricultural ingredients. The invention comprises methods of making such compositions. The yeast components of the compositions may be derived from yeast cultures which comprise at least 0.1% oil by dry weight.

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Номер записи: 27
07-02-2019 дата публикации

Cranberry Extract Useful in the Treatment and Prevention of Urinary Infections

Номер: US20190038595A1
Автор: Bochard Valerie, Charissou Lucie, Jacob Morgane, Lastique Benedicte, Sanoner Philippe, Thomas Patrice
Принадлежит:

The present invention relates to a concentrated extract of cranberry (), the complex composition of which makes it possible to increase the antibacterial effects thereof, which is of use for the prevention or treatment of urinary infections, and in particular for the preventive treatment of urinary infections or treatment against the recurrence thereof. The invention also relates to a process for preparing such an extract, to food, nutraceutical or pharmaceutical compositions comprising the extract and to the use thereof in the treatment or prevention of urinary infections. 2. The dry cranberry extract according to claim 1 , wherein the dry cranberry extract is a de-esterified extract.3. The dry cranberry extract according to claim 1 , wherein the polymers of PACs having a degree of polymerization greater than or equal to 4 represent at least 30% by weight claim 1 , in relation to the weight of all PACs present in the extract.5. The process according to claim 4 , wherein:the water-soluble fraction used in step a) is cranberry juice and the water-insoluble fraction used in step b) is cranberry marc, or i) Crushing whole cranberries, and', 'ii) Decanting and separating the water-soluble and water-insoluble fractions., 'The water-soluble fraction used in step a) and the water-insoluble fraction used in step b) were obtained from whole cranberries, by6. The process according to claim 4 , wherein fraction I is obtained in step a) by the following steps: adsorption of the water-soluble fraction on a non-polar support,', 'washing with a polar solvent and collecting polar fraction Ia, and', 'eluting and collecting non-polar fraction Ib;, 'a1) separating non-polar compounds and polar compounds by adsorption of fraction Ia on ion-exchange resin,', 'washing with aqueous solvent,', 'eluting with acidic solvent and collecting fraction Ic comprising organic acids;, 'a2) separating organic acids and sugars present in polar fraction Ia bya3) Combining fractions Ib and Ic to form ...

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Номер записи: 28
07-02-2019 дата публикации

DECARBOXYLATED CANNABIS RESINS, USES THEREOF AND METHODS OF MAKING SAME

Номер: US20190038663A1
Автор: Grover Har, Kotra Lakshmi Premakanth, Lewis Melissa Maureen, Wasilewski Ewa
Принадлежит:

The disclosure relates to decarboxylated resins and methods of making the decarboxylated resins by extraction and decarboxylation of cannabinoids from species using microwaves and solvents. The disclosure also relates to use of the decarboxylated resins for making pharmaceutical products comprising same. 1cannabisCannabis. A decarboxylated resin , wherein the resin comprises decarboxylated cannabinoids from a spp. plant , such that Δ9-tetrahydrocannabidiolic acid (Δ9-THCA) and cannabidiolic acid (CBDA) cannabinoids in the plant are each independently 90% to 100% decarboxylated to yield Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) respectively in the resin.2cannabis. The decarboxylated resin of claim 1 , wherein the resin further comprises cannabinol (CBN).3cannabis. The decarboxylated resin of claim 1 , where the resin is substantially free of solvent.4cannabis. A pharmaceutical product comprising (i) the decarboxylated resin of and (ii) a suitable pharmaceutically acceptable carrier or excipient.5cannabis. A natural health product comprising the decarboxylated resin of .6cannabis. A method of extracting and decarboxylating cannabinoids from claim 1 , the method comprising:{'i': cannabis', 'cannabis, '(i) extracting cannabinoids by contacting the with a solvent thereby forming a extract; and'}{'i': cannabis', 'cannabis', 'cannabis, '(ii) decarboxylating the cannabinoids in the extract by subjecting the extract to microwaves at temperature of about 100-200° C. in a sealed container for a time period sufficient to form the corresponding decarboxylated cannabinoids in the extract.'}7cannabiscannabis. The method of claim 6 , wherein before the step (i) of extracting claim 6 , the is broken down to produce of a size and form suitable for extraction.8. The method of claim 6 , wherein the extracting and decarboxylating steps occur concurrently.9. The method of claim 6 , wherein the solvent is selected from the group consisting of: 80-100% ethanol claim 6 , ethylene ...

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Номер записи: 29
07-02-2019 дата публикации

Vaporized Medicants and Methods of Use

Номер: US20190038693A1
Автор: Bartkowski William P, Chong Alexander ChinHak, Thompson Marshall A
Принадлежит:

A method and formulation for delivering a PDE-5 inhibitor in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the PDE-5 inhibitor. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer. 1. A method for delivering medicants through inhalation , comprising: i. an excipient comprising propylene glycol present at approximately 1 percent to approximately 30 percent of the excipient, vegetable glycerin present at approximately 1 percent to approximately 30 percent of the excipient, water present at approximately 0.01 percent to approximately 30 percent of the excipient, and alcohol present at approximately 0.01 percent to approximately 30 percent of the excipient, and', 'ii. phosphodiesterase type 5 inhibitor; and, 'a. acquiring a medicant solution suitable for vaporization, the medicant solution, comprisingb. vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the medicant solution is provided to a user for inhalation, wherein the step of vaporizing the medicant solution comprises using a vaporizer.2. A method for delivering medicants through inhalation , comprising: i. an excipient comprising an inert non-reactive compound, and', 'ii. a phosphodiesterase type 5 inhibitor; and, 'a. acquiring a medicant solution suitable for vaporization, the medicant solution, comprisingb. vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. within 2 minutes of activation such that an effective serving ...

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Номер записи: 30
06-02-2020 дата публикации

Process for preventing or slowing the appearance of unattractive signs, generated by pollutants present in the atmosphere, on the skin, the scalp, the hair or the mucous membranes

Номер: US20200038314A1
Автор: Armelle BERGE, Erwan LE GELEBART, Laetitia Cattuzzato
Принадлежит: BiotechMarine SAS, Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA

Process with the aim of preventing or slowing the appearance of unattractive signs, generated by the pollutants present in the atmosphere, on the skin, the scalp, the hair or the mucous membranes, or indeed of eliminating them, including a step of application of a cosmetic formulation for topical use, including at least one cosmetically acceptable excipient and an effective amount of at least one glycolic extract (GE) of a unialgal biomass of small multicellular macroalgae originating from the Florideophyceae class. The extract, for the use thereof in a therapeutic method for treating signs of irritation of the skin, the scalp or the mucous membranes, manifesting as redness, sensations of stinging and/or itching, signs of deterioration of the hair, manifesting as an increase in the porosity thereof, the dulling thereof, and/or the weakening thereof with regard to mechanical stresses.

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Номер записи: 31
12-02-2015 дата публикации

Process for fractionation and extraction of herbal plant material to isolate extractives for pharmaceuticals and nutraceuticals

Номер: US20150044306A1
Автор: James Etson Brandenburg, Jr., Melvin Mitchell
Принадлежит: GREEN EXTRACTION TECHNOLOGIES

A process for fractionating a plant material to provide isolated extractives, the process includes pretreating the plant material to provide a fluidized plant material, subjecting the pretreated fluidized plant material to high frequency pulses and shear forces without denaturing bioactive aspects of one or more components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, separating the first liquid fraction having extractives from the first fractionated plant material, and isolating extractives from the first liquid fraction.

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Номер записи: 32
18-02-2016 дата публикации

Method for making coffee products containing cannabis ingredients

Номер: US20160044934A1
Автор: Christopher Bhairam
Принадлежит: Imbue LLC

The present disclosure is directed to methods of making a coffee products containing cannabinoids that are extracted from Cannabis plant. According to one embodiment, the method includes the steps of (a) extracting cannabinoids from Cannabis plant; and (b) admixing the cannabinoids into a coffee product. The disclosed methods produce coffee products that possesses the benefits of both coffee and Cannabis plant. The methods can be used to produce different coffee products including single-serve coffee pods, ground coffee, and espresso. The methods are used to make coffee products with desired and consistent amount of tetrahydrocannabinol (THC).

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Номер записи: 33
15-02-2018 дата публикации

DEVELOPMENT OF A STANDARDIZED AND EFFECT-OPTIMIZED HERBAL EXTRACT OF WEDELIA CHINENSIS AND ITS USE FOR TREATING DISEASE

Номер: US20180042977A1
Автор: HSIAO Pei-Wen, Hsieh Shih-Chuan, Tsai Chin-Hsien
Принадлежит:

A method for preparing a standardized extract and an extract prepared by the method. Also provided is a method for qualifying the standardized extract by characterizing its most abundant compounds and its biological activity in vitro. Additionally, a method is provided for treating an androgen-stimulated disorder with the qualified extract. 1Wedelia chinensis. A method for preparing a standardized extract , the method comprising:{'i': 'Wedelia chinensis;', 'providing an ethanolic extract of'}acid-hydrolyzing the ethanolic extract;neutralizing the acid-treated ethanolic extract;applying the neutralized acid-treated ethanolic extract to a reverse phase column;eluting and collecting fractions from the reverse phase column;assaying in vitro the collected fractions for anti-androgen receptor activity; andcombining fractions having the highest anti-androgen receptor activity amongst the collected fractions.2. The method of claim 1 , wherein the eluting step is achieved with a water:ethanol gradient.3. The method of claim 2 , wherein the water:ethanol gradient is from 80% water: 20% ethanol to 50% water: 50% ethanol by volume.4. The method of claim 3 , wherein six fractions are collected.5. The method of claim 4 , wherein in the combining step claim 4 , two fractions having the highest anti-androgen receptor activity as compared to the anti-androgen receptor activity of each of the fractions are combined.6. The method of claim 1 , wherein the anti-androgen receptor activity is determined by a prostate-specific antigen promoter/reporter assay.7. The method of claim 6 , wherein the fractions having the highest anti-androgen receptor activity have an IC≦300 ng/ml in the reporter assay.8Wedelia chinensis. A composition comprising a standardized extract prepared by the method of .9Wedelia chinensis. A method for qualifying a standardized preparation of a extract for treating an androgen-stimulated disorder claim 1 , the method comprising:{'i': 'Wedelia chinensis', 'obtaining a ...

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Номер записи: 34
18-02-2021 дата публикации

STEROL DERIVATIVES AND PREPARATION METHOD AND USES THEREOF

Номер: US20210047364A1
Автор: Duan Zhenwen, Guo Shuren, Li Xuemei
Принадлежит:

The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, Ris selected from the group consisting of —OH, ═O(carbonyl), H, and C-Calkyl; Ris selected from the group consisting of —OH, H, and C-Calkyl; Ris selected from the group consisting of —OH, ═O, H, and C-Calkyl; Ris selected from the group consisting of —OH, H, and C-Calkyl; and none, one, two, three or four of R, R, R, and Rare —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight. 4. The method of wherein the compound is tetraacetate of compound of Formula II claim 1 , tetra-p-tolylsulfonate of compound of Formula II claim 1 , tetra(trifluoromethylsulfonate) of compound of Formula II claim 1 , or tetra(tert-butyl-dimethyl-silyl ether) of compound of Formula II.5. The method of wherein reducing or regulating blood lipid levels comprises treating or preventing dyslipidemia claim 1 , hyperlipemia claim 1 , hypercholesterolemia claim 1 , or atherosclerosis.8. The method of claim 6 , wherein the tumor cells are colon cancer cells claim 6 , liver cancer cells claim 6 , lymph cancer cells claim 6 , or melanoma cells.10. The method of wherein the compound is tetraacetate of compound of Formula II claim 6 , tetra-p-tolylsulfonate of compound of Formula II claim 6 , tetra(trifluoromethylsulfonate) of compound of Formula II claim 6 , or tetra(tert-butyl-dimethyl-silyl ether) of compound of Formula II.13. The method of wherein the subject has hyperlipidemia claim 11 , atherosclerosis claim 11 , coronary heart disease claim 11 , diabetes claim 11 , or a combination thereof.15. The method of wherein the compound is tetraacetate of compound of Formula II claim ...

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Номер записи: 35
03-03-2022 дата публикации

Device for tableting a powder, liquid, paste, encapsulated or granular active ingredient composition

Номер: US20220062108A1
Автор: Fritz Schmitt
Принадлежит: Individual

The invention relates to a device for tabletting a powdered, liquid, pasty, encapsulated or granular active ingredient composition, having a magazine which has a plurality of active ingredient containers each with an individually controllable dosing device and a nozzle for the active ingredient outlet, wherein the magazine is adjustable between a plurality of setting positions relative to at least one die chamber, wherein in each of the setting positions at least one of the nozzles faces an opening of the die chamber. A corresponding method is further described.

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Номер записи: 36
03-03-2022 дата публикации

FEIJOA FRUIT EXTRACT

Номер: US20220062366A1
Автор: Foo Lai Yeap, Watson Ronald Ross
Принадлежит:

The invention relates to a feijoa fruit extract. In particular the invention relates to therapeutic uses of a feijoa fruit extract, processes for preparing the extract, and compositions comprising the extract. The feijoa fruit extract of the invention can be used in the treatment and prevention of rheumatoid arthritis and Type-2 diabetes.

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Номер записи: 37
19-02-2015 дата публикации

Compounds from Anisomeles Heyneana

Номер: US20150051277A1
Автор: Dhiman SARKAR, Ketaki Dilip SHURPALI, Roshan Rajan KULKARNI, Sampa Sarkar, Swati Pramod JOSHI
Принадлежит: Council of Scientific and Industrial Research CSIR

The present invention describes use of compounds of formula 1 or 2 or their compositions for the treatment of leukemia and use of compound of formula 1 or its composition for treatment of infections caused due to M. tuberculosis. The invention further discloses use of compound of formula 3 for the conversion of solar energy into electric current in dye sensitized solar cells. Also, the present invention discloses a process of extraction of compounds of formula 1 or 2 or 3 from the extract of aerial parts of Anisomeles heyneana

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Номер записи: 38
13-02-2020 дата публикации

Phospholipid Compositions

Номер: US20200046744A1
Автор: DUEX Jason, HUDSON Colleen, JIRKOVSKY Pavel, KANDASAMY Pitchaimani, KOBR Lukas, MIKNIS Gregory, MILADA Zboncåkovå, Monfregola Luca, STASZAK-JIRKOVSKY Jakub
Принадлежит:

Compositions involving a modified egg yolk extract for use as an effective anti-cancer agent are described. The modified egg yolk extract involves specific fractions of phosphatidylcholines and sphingomyelins modified and produced from a chemical synthesis applied to the extract that produce a beneficial effect on the inhibition of cancerous cell growth. Methods of administering these compositions are also described. 1 1-palmitoleoyl-2-linoleoyl-sn-glycero-3-phosphocholine,', '1-palmitoyl-2-α-linolenoyl-sn-glycero-3-phosphocholine,', '1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine,', '1,2-dilinoleoyl-sn-glycero-3-phosphocholine,', '1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine,', '1-α-linolenoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine,', '1-palmitoleoyl-2-oleoyl-sn-glycero-3-phosphocholine,', '1-palmitoleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine,', '1-palmitoyl-2-osbondoyl-sn-glycero-3-phosphocholine,', '1-oleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine,', '1-oleoyl-2-linoleoyl-sn-glycero-3-phosphocholine,', '1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine,', '1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine,', '1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine,', '1,2-dioleoyl-sn-glycero-3-phosphocholine,', '1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, and', '1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine., 'wherein said plurality of phosphatidylcholine compounds comprise 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine and one or more phosphatidylcholines selected from the group consisting of. A method of treating lung cancer in a human patient in need thereof comprising administering to said patient a pharmaceutical composition consisting of a plurality of phosphatidylcholine compounds and one or more pharmaceutically acceptable diluents, excipients, and/or carriers; This application is a continuation of and claims priority under 35 U.S.C. § 120 to U.S. application Ser. No. 15/637,126, filed Jun. 29, 2017, ...

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Номер записи: 39
10-03-2022 дата публикации

Method for producing xanthohumol-containing composition

Номер: US20220071926A1
Автор: Koichi Nakahara, Risa Takagi, Takaaki Yoshii, Yuto Hata
Принадлежит: Suntory Holdings Ltd

The present invention relates to, for example, a method of producing a xanthohumol-containing composition, including: contacting a first mixture of a hop-derived, xanthohumol-containing component and a first solvent containing water and a water-miscible solvent with polyvinylpolypyrrolidone to adsorb xanthohumol on the polyvinylpolypyrrolidone; washing the polyvinylpolypyrrolidone containing xanthohumol adsorbed thereon with a second solvent; and eluting xanthohumol from the polyvinylpolypyrrolidone with a third solvent to obtain a xanthohumol-containing eluate, wherein the second solvent is an aqueous ethanol solution, and the third solvent is ethanol or an aqueous ethanol solution having a higher concentration than the second solvent.

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Номер записи: 40
03-03-2016 дата публикации

Methods and compounds for intensive skin repair and healing including active organic and synthetic compounds

Номер: US20160058820A1
Автор: Pat K. Criscito
Принадлежит: Desert Harvest

A skin treatment compound includes Lidocaine and aloe vera . The aloe vera is Barbadensis Miller species. Optionally, the skin treatment compound includes Calendula . Alternatively, the skin treatment compound includes natural preservatives. Optionally, the natural preservatives include Leuconostoc /Radish Root Ferment Filtrate, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Extract, Populus Tremuloides (Aspen) Bark Extract, and Gluconolactone.

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Номер записи: 41
04-03-2021 дата публикации

Method for obtaining saponins from plants

Номер: US20210060106A1
Автор: Andres VALENCIA MICHAUD, Leandro PADILLA IGLESIAS
Принадлежит: Desert King Chile SA

The present application relates to a method for obtaining and purifying saponins from plant extracts, through a series of salting and filtrations steps, to provide high purity saponin extracts on large scale.

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Номер записи: 42
04-03-2021 дата публикации

INULA HELENIUM EXTRACTS FOR TREATING AND PREVENTING POLLUTION RELATED DAMAGE

Номер: US20210060108A1
Автор: BEN-CHITRIT Olga, HAVAS Fabien, PERRY Inon, VON OPPEN-BEZALEL Leah
Принадлежит:

Extracts derived from plants and/or fractions thereof, compositions comprising same and methods and use thereof in protecting tissues from damage caused by toxins are encompassed herein. More particularly, compositions comprising a polar solvent extract and/or a fraction thereof derived from an plant (e.g., ) and methods and use thereof in protecting tissues comprising epithelial cells from adverse effects of toxins, particularly exogenous toxins originating from environmental pollution, are encompassed herein. 1: A method for protecting a tissue comprising epithelial cells from adverse effects of at least one pollutant , the method comprising administering to a subject in need thereof at least one of:{'i': 'Inula', '(a) a polar solvent extract derived from an plant,'}{'i': 'Inula', '(b) a fraction of the polar solvent extract derived from an plant, or'}{'i': Inula', 'Inula, '(c) a composition comprising the polar solvent extract derived from an plant or the fraction of the polar solvent extract derived from an plant,'}in an effective amount sufficient to protect the tissue comprising epithelial cells from adverse effects of the at least one pollutant, thereby protecting the tissue from the at least one pollutant.2: The method of claim 1 , wherein the administering is performed before claim 1 , during claim 1 , or after exposure to the at least one pollutant.39-. (canceled)10: The method of claim 1 , wherein the tissue is skin and wherein the method comprises topically administering at least one of the polar solvent extract claim 1 , the fraction of the polar solvent claim 1 , and the composition comprising the polar solvent extract or the fraction thereof to the skin.1122-. (canceled)23: The method of claim 1 , wherein the polar solvent is water.24: The method of claim 1 , wherein the polar solvent comprises water and at least one additional polar solvent selected from the group of glycerin claim 1 , ethanol claim 1 , propylene glycol claim 1 , butylene glycol ...

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Номер записи: 43
20-02-2020 дата публикации

CANNABIS OIL EXTRACTS AND COMPOSITIONS

Номер: US20200054701A1
Автор: Bestwick Haley Poole, Finley Constance, McKee Luke, Roethle Paul
Принадлежит: Constance Therapeutics, Inc.

The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition. 127.-. (canceled)28. A composition comprising:a cannabis oil extract and vitamin E;wherein the quantity of the cannabis oil extract ranges from about 50% w/w to about 90% w/w based on the total weight of the composition;wherein the quantity of vitamin E ranges from about 10% w/w to about 35% w/w based on the total weight of the composition;wherein the cannabis oil extract contains:a neutral cannabinoid in an amount ranging from about 10% w/w to about 95% w/w, oran acidic cannabinoid in an amount ranging from about 10% w/w to about 80% w/w; andwherein the composition is contained in a cartridge for pulmonary administration.29. The composition of claim 28 , wherein the quantity of vitamin E is from about 15% w/w to about 20% w/w based on the total weight of the composition.30. The composition of claim 28 , wherein the quantity of vitamin E is from about 20% w/w to about 25% w/w based on the total weight of the composition.31. The composition of claim 28 , wherein the quantity of vitamin E is from about 25% w/w to about 30% w/w based on the total weight of the composition.32Cannabis indicaCannabis sativa,. The composition of claim 28 , wherein the extract is prepared from a strain of cannabis plant ...

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Номер записи: 44
28-02-2019 дата публикации

Powder formulation having hypoglycemic and hypolipidemic functions and method for preparing the same

Номер: US20190060391A1
Автор: Fang Lv, Hongwei Zhao, Qingtao TANG
Принадлежит: Infinitus China Co Ltd

The present disclosure relates to the field of health care products, disclosing a powder made from inulin, FOLIUM CYCLOCARYA PALIURUS, RHIZOMA DIOSCOREA OPPOSITE, RADIX ASTRAGALUS MEMBRANACEUS, CAULIS DENDROBIUM and RADIX ET RHIZOMA SALVIA MILTIORRHIZA. The raw materials of the powder are all from natural Chinese herbal medicine without addition of excipient. In addition, dosage required for the powder is small; it can be directly dissolved in water for taking; it is soluble in cold water and can be absorbed quickly. The method for preparing the powder in the present disclosure is simple and suitable for large-scale production. Also, it is easy to be carried. The powder obtained has a good stability and long storage time. Experiments show that the powder of the present disclosure has greatly hypoglycemic and hypolipidemic effects, therefore can be used to prepare the health care foods having hypoglycemic and hypolipidemic effect.

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Номер записи: 45
27-02-2020 дата публикации

Method for making coffee products containing cannabis ingredients

Номер: US20200060305A1
Автор: Christopher Bhairam, Zachary Bell
Принадлежит: Blacklist Holdings Inc

The present disclosure is directed to methods of making coffee products containing cannabinoids that are extracted from Cannabis plant. According to one embodiment, the method includes the steps of (a) extracting cannabinoids from the Cannabis plant; and (b) admixing the cannabinoids into a coffee product. The disclosed methods produce coffee products that possess the benefits of both coffee and Cannabis plant. The methods can be used to produce different coffee products including single-serve coffee pods, ground coffee, espresso and coffee extracts. The methods are used to make coffee and other products with desired and consistent amount of Cannabis-derived compounds.

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Номер записи: 46
22-05-2014 дата публикации

Anti-glycation agent comprising a garcinia kola extract or fraction

Номер: US20140142171A1
Автор: Alexis Kaatio Toure, Pascale RICHOMME, Severine Derbre, Sylvie Morel
Принадлежит: LABORATOIRE SHIGETA, Universite dAngers

An anti-glycation agent includes a Garcinia kola extract or fraction. The compositions including the extract or the fraction are used to inhibit the glycation of proteins, in particular the glycation of skin proteins involved in cutaneous aging. A method for determining the activity of compounds for inhibiting the glycation of cutaneous proteins, in particular for inhibiting the glycation of collagen is also described.

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Номер записи: 47
10-03-2016 дата публикации

Eye-refreshing agent to eliminate and alleviate eye fatigue and discomfort

Номер: US20160067297A1
Автор: Jianxue Wei
Принадлежит: Jianxue Wei

An eye-refreshing agent, the raw materials of which include mung bean germs, eucalyptus leaves, mint leaves, clove leaves, camphor leaves and borneol. The plant cells thereof are respectively subjected to crushing, low-temperature freezing and centrifugation and sound membrane separation to prepare a water-soluble preparation. The preparation can prevent and alleviate visual fatigue and accelerate metabolism of the eye skin cells, and also has the effect of alleviating and improving eye bags and eye pseudo-wrinkles caused by eye fatigue.

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Номер записи: 48
27-02-2020 дата публикации

Powder solid compositions, process for their preparation, formulations and use thereof

Номер: US20200061143A1
Автор: Giacomo Mombelli, Massimo Ronchi
Принадлежит: Idena SpA, Indena SpA

Disclosed are powder solid compositions including a hydroalcoholic extract of Bergamot fruit (Citrus aurantium var. bergamia) and at least one phospholipid. Also disclosed is a process for the preparation of the compositions. The compositions are useful for the prevention and/or treatment of dysmetabolic syndromes, dyslipidemias and type 2 diabetes.

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Номер записи: 49
08-03-2018 дата публикации

COMPOSITIONS OF MEDICINAL PLANTS FOR REDUCING THE EFFECTS OF AGING, PREVENTION AND TREATMENT OF AGE-RELATED NEURODEGENERATIVE DISEASES, AND TREATMENT OF ANXIETY AND SLEEP DISORDERS

Номер: US20180064773A1
Автор: Xue Hong
Принадлежит:

Compositions comprising extracts prepared from mixtures of the herbal plants Radix DC (“B”), Rhizoma WT Wang (“Y”), Caulis Thunb (“P”) and Flos Durazz (“A”) are provided. The BYP, BYA, BPA, BY, BP, YP and BYPA extracts significantly decreased one or more of the effects of accelerated aging in mice exposed to D-galactose, including spatial memory deficit, and elevated oxidative stress marker malondialdehyde and pro-inflammatory cytokines TNF-alpha and IL-6 in the brain, indicating efficacy in reducing the damage of aging, and preventing and treating Alzheimer's disease and/or Parkinson's disease. Anxiolysis by the BYA, BPA, YPA, BA and PA extracts indicates efficacy for treating anxiety disorders, and the sedative effect of the BYA, YPA and PA extracts indicates efficacy for treating sleep disorders. None of the extracts significantly induced alteration in locomotor activity, decreased muscle coordination, or anterograde amnesia at the maximum oral dose tested. 1. A composition comprising an extract or a dried powder of an extract , the extract being derived from a mixture of plants , the plants comprising:{'i': Bupleurum chinense', 'Corydalis yanhusuo', 'Polygonum multiflorum, '(a) Radix DC, Rhizoma WT Wang, and CaulisThunb, the composition being free of Flos Albizia julibrissin Durazz'}{'i': Bupleurum chinense', 'Corydalis yanhusuo', 'Albizia julibrissin', 'Polygonum multiflorum, '(b) Radix DC, Rhizoma WT Wang, and Flos Durazz, the composition being free of Caulis Thunb;'}{'i': Bupleurum chinense', 'Polygonum multiflorum', 'Albizia julibrissin', 'Corydalis yanhusuo, '(c) Radix DC, Caulis Thunb, and Flos Durazz, the composition being free of Rhizoma WT Wang;'}{'i': Corydalis yanhusuo', 'Polygonum multiflorum', 'Albizia julibrissin', 'Bupleurum chinense, '(d) Rhizoma WT Wang, Caulis Thunb, and Flos Durazz, the composition being free of Radix DC;'}{'i': Bupleurum chinense', 'Corydalis yanhusuo', 'Polygonum multiflorum', 'Albizia julibrissin, '(e) Radix DC and Rhizoma ...

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Номер записи: 50
11-03-2021 дата публикации

ANTIOXIDANT ENRICHED DISTILLED ALCOHOL PRODUCT AND PROCESS THEREFOR

Номер: US20210069279A1
Автор: Gillis Alan B., Gillis Judith M., Gillis Rodney J., LEE Hyun Suk
Принадлежит:

A process for producing a distilled ethanol product comprising an antioxidant component and an ethanol component is described. In the process, plant matter containing antioxidants is washed, frozen and exposed to an input volume of ethanol. Antioxidants are ethanolically extracted from the frozen plant matter. The plant matter and the liquid ethanol fractions are then separated and the plant matter having antioxidants extracted therefrom is used to produce ethanol which is subsequently used to extract antioxidants from a second batch of plant matter. The ethanol fraction having antioxidants therein is stored or diluted for later use. 1. A process for producing an antioxidant containing distilled ethanol product comprising:freezing antioxidant containing plant matter, suitable for use in the production of ethanol, to render a frozen plant material;subjecting the frozen plant material to a volume of a distilled input ethanol product so as to ethanolically extract antioxidants from the frozen plant material and render an antioxidant-rich ethanol fluid mixture having therein remnant solid plant matter;separating the remnant solid plant matter from the antioxidant-rich ethanol fluid mixture so as to obtain said antioxidant containing distilled ethanol product; andproducing a subsequent distilled ethanol product from said remnant solid plant matter; the subsequent distilled ethanol product being used as the distilled input ethanol product in subsequent cycles for producing at least a further volume of said antioxidant containing distilled ethanol product.2. The process as defined in claim 1 , wherein the frozen plant material is subjected to the volume of distilled input ethanol product until the remnant solid plant matter is substantially devoid of antioxidants.3. The process as defined in claim 1 , wherein the distilled input ethanol product has an ethanol concentration of from about 70% to about 99%.4. The process as defined in claim 1 , wherein the frozen plant ...

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Номер записи: 51
17-03-2022 дата публикации

Post-harvest optimization

Номер: US20220083946A1
Автор: Denis TASCHUK, Jim SEETHRAM, Michael CABIGON, Steven Splinter
Принадлежит: Radient Technologies Innovations Inc

Methods and apparatus consistent with the present disclosure may provide information to growers of Cannabis plants such that Cannabis plant biomass extractors could optimize process parameters based on growing and post processing conditions of a batch of Cannabis plants. Parameters associated with the growth and processing of Cannabis, include light, nutrition, water, humidity. Each of these parameters may affect the size, density, moisture content, cannabinoid content, or other features of a Cannabis biomass. These methods and apparatus may also help farmers protect their crop from damage by mold infestation, for example or from theft. Methods consistent with the present disclosure may analyze data from a set of sensors when Cannabis plant biomass is prepared for extraction. These sensors may collect data from the processing steps of cutting, trimming, drying, and curing when Cannabis plant matter is prepared for extraction.

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Номер записи: 52
24-03-2022 дата публикации

Apparatuses, methods, and systems for extraction, isolation and conversion of various cannabinoids, and modifications of whole-plant hemp extracts therewith

Номер: US20220087973A1
Автор: Alexander Michael McCorkle, Graham Taylor Carlson, Shelby Renee Sheahan
Принадлежит: Charlottes Web Inc

Apparatuses, methods, and systems for extraction, isolation, purification, and conversion of various cannabinoids, and modifications of whole-plant hemp extracts therewith are presented. A method for preparing a whole-plant hemp extract based product includes extracting cannabinoids from plant materials, such as one or more hemp varieties of Cannabis sativa. The method also includes separating and purifying CBD from the extracted cannabinoids, converting purified CBD to Δ9-THC and Δ8-THC and concurrently converting Δ9-THC to CBN, purifying and separating the CBN, and combining the purified CBN with a whole-plan hemp extract. Products and supplements related to the method are also described.

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Номер записи: 53
17-03-2016 дата публикации

Pharmaceutical composition and method of manufacturing

Номер: US20160074451A1
Автор: Gary J. Speier
Принадлежит: Individual

The present invention provides for methods of obtaining an extract of Cannabis plant material as well as subsequent processing of the extract to provide a concentrate of Cannabis . The present invention also provides for pharmaceutical dosage forms (e.g., oral thin films and transdermal patches) that include the concentrate (or extract) of Cannabis , as well as methods of medical treatment that include administering the pharmaceutical dosage forms.

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Номер записи: 54
15-03-2018 дата публикации

USE OF ISOLATED FRACTIONS OF MASTIC GUM FOR TREATING OPTIC NEUROPATHY

Номер: US20180071351A1
Автор: ADAMSKY Konstantin, Hazan Zadik, Lucassen Andre C. B.
Принадлежит: REGENERA PHARMA LTD.

The invention relates to therapeutic uses of isolated fractions of mastic gum for treating optic neuropathy. More particularly, the invention relates to methods of treating optic neuropathy conditions using compositions comprising isolated fractions of mastic gum. 133-. (canceled)34. A method of treating optical neuropathy condition , the method comprising administering to a subject in need thereof a therapeutically effective amount of an isolated fraction of mastic gum and a pharmaceutically acceptable carrier , wherein the isolated fraction of mastic gum is characterized in that it is soluble in at least one polar organic solvent and in at least one non-polar organic solvent , and wherein the isolated fraction of mastic gum is substantially devoid of compounds which are soluble in said polar organic solvent but insoluble in said non-polar organic solvent , thereby treating the optical neuropathy condition.35. The method of claim 34 , wherein the optic neuropathy condition is selected from traumatic neuropathy claim 34 , ischemic neuropathy; Radiation optic neuropathy (RON) claim 34 , Glaucoma claim 34 , Optic neuritis claim 34 , Compressive optic neuropathy claim 34 , Infiltrative optic neuropathy claim 34 , Mitochondrial optic neuropathy claim 34 , Nutritional optic neuropathies claim 34 , toxic optic neuropathies claim 34 , Hereditary optic neuropathy and combinations thereof.36. The method of claim 35 , wherein the ischemic neuropathy optic is selected from: Non arteritic Iscehmic neuropathy (NAION) claim 35 , Anterior ischemic optic neuropathy (AION) and Posterior ischemic optic neuropathy.37. The method of claim 34 , wherein the optic neuropathy condition resulted from a storage disease.38. The method of claim 37 , wherein the storage disease causes a deposition of lipoprotenaceous substances in the optical nerve.39. The method of claim 34 , wherein the composition is administered by parenteral route claim 34 , selected from intravenous claim 34 , ...

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Номер записи: 55
15-03-2018 дата публикации

Composition for wound treatment containing extract of stellera chamaejasme or fraction thereof and method for treating wound of subject

Номер: US20180071355A1
Автор: Chu Won Nho, Dulamjav BATSUREN, Hee Ju Lee, Kil Choo Moon, Myung Suk Kim, Sang Rok Oh
Принадлежит: Korea Advanced Institute of Science and Technology KAIST

Provided are a composition including Stellera chamaejasme extract for treating wound, a method of treating wound of a subject, a cosmetic composition for wound improving, skin wrinkle improving, or skin anti-aging, and a method of cosmeticizing for wound improving, skin wrinkle improving, or skin anti-aging.

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Номер записи: 56
31-03-2022 дата публикации

Device and method for extracting and aspirating active substances, especially from the cannabis plant

Номер: US20220095681A1
Автор: Fritz Schmitt
Принадлежит: Individual

The invention relates to a capsule for use in a vaporizer, having at least one first cavity formed at least in part by a lid, side walls and bottom of the capsule, and a vaporizable active substance accommodated in the first cavity of the capsule, wherein the side walls and/or the bottom are at least in sections double-walled with an inner wall facing the first cavity of the capsule and an outer wall facing the outside of the capsule, so that at least one second cavity is formed between the inner wall and the outer wall of the capsule, inner wall facing the first cavity of the capsule and an outer wall facing the outside of the capsule, so that at least one second cavity is formed between the inner wall and the outer wall, wherein an auxiliary substance, preferably a further active substance, a chemical reactant and/or a flavoring agent is accommodated in the second cavity. A corresponding vaporizer as well as a corresponding vaporizer system are further described.

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Номер записи: 57
22-03-2018 дата публикации

METHODS OF PREPARING STEVIOL GLYCOSIDES AND USES OF THE SAME

Номер: US20180079767A1
Автор: Bin Nawi Khairul Nizam, Chow Siew Yin, MARKOSYAN Avetik
Принадлежит:

Methods of preparing steviol glycosides, including Rebaudioside D, Rebaudioside E, Rebaudioside M, Rebaudioside N and Rebaudioside O are provided herein. Sweetener and sweetened consumables containing Rebaudioside D, Rebaudioside E, Rebaudioside M, Rebaudioside N and Rebaudioside O are also provided herein. 1. A method for preparing steviol glycosides composition comprising steps of: (a) passing a feed solution of steviol glycosides through a column packed with a polymer resin; and (b) eluting fraction(s) with high content of Reb D , Reb E , Reb M , Reb N and Reb O to provide an eluted solution with high content of Reb D , Reb E , Reb M , Reb N and Reb O , wherein the Reb DEMNO/T13SG ratio is higher than Reb DEMNO/T13SG ratio of feed solution.2Stevia rebaudianastevia. The method of claim 1 , wherein step (a) feed solution of steviol glycosides comprises a solvent and steviol glycoside selected from group including but not limited to purified plant material claim 1 , commercially available extract claim 1 , commercially available mixtures of steviol glycosides claim 1 , by-products of other steviol glycosides' isolation and purification processes claim 1 , synthetic or biosynthetic steviol glycosides claim 1 , e.g. enzymatically glycosylated steviol glycosides claim 1 , steviol glycoside products from bioconversion of steviol glycosides by biocatalysts claim 1 , steviol glycosides from fermentation of recombinant microbial host capable of de novo synthesis of steviol glycosides claim 1 , and combinations thereof.3. The method of claim 1 , wherein an initial solvent comprising either pure water claim 1 , or aqueous acid claim 1 , or alcohol-water claim 1 , or alcohol-aqueous acid mixtures with less than forty volume percent alcohol is used to elute fraction(s) with high content of Reb D claim 1 , Reb E claim 1 , Reb M claim 1 , Reb N and Reb O.4. The method of claim 1 , further comprising removal of the solvent to give a dry solid containing higher Reb DEMNO/T13SG ...

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Номер записи: 58
23-03-2017 дата публикации

DECOCTION OF OLIVE LEAVES

Номер: US20170080040A1
Автор: Pesle Livio
Принадлежит:

A decoction of olive leaves comprises an aqueous composition containing at least from about 500 mg/liter to about 3,000 mg/liter of oleuropein, from about 100 mg/liter to about 300 mg/liter of hydroxytyrosol, from about 90 mg/liter to about 280 mg/liter of tyrosol, from about 400 mg/liter to about 1,800 mg/liter of elenolic acid. 1. Decoction of olive leaves comprising an aqueous composition containing at least:from about 500 mg/liter to about 3,000 mg/liter of oleuropein;from about 100 mg/liter to about 300 mg/liter of hydroxytyrosol;from about 90 mg/liter to about 280 mg/liter of tyrosol;from about 400 mg/liter to about 1,800 mg/liter of elenolic acid;from about 100 mg/liter to about 600 mg/liter of rutin;wherein said decoction is an extract of said olive leaves obtained by hot water extraction.2. Decoction as in claim 1 , wherein said decoction has a slightly bitter taste.3. Decoction as in claim 1 , wherein the content of oleuropein is comprised between about 600 mg/liter and about 2 claim 1 ,850 mg/liter.4. Decoction as in claim 1 , wherein the content of oleuropein is comprised between about 700 mg/liter and about 2 claim 1 ,800 mg/liter.5. Decoction as in claim 1 , wherein the content of hydoxytyrosol is comprised between about 110 mg/liter and about 290 mg/liter.6. Decoction as in claim 1 , wherein the content of hydoxytyrosol is comprised between about 140 mg/liter and about 280 mg/liter.7. Decoction as in claim 1 , wherein the content of tyrosol is comprised between about 95 mg/liter and about 270 mg/liter.8. Decoction as in claim 1 , wherein the content of tyrosol is comprised between about 110 mg/liter and about 250 mg/liter.9. Decoction as in claim 1 , wherein the content of elenolic acid is comprised between about 600 mg/liter and about 1 claim 1 ,800 mg/liter.10. Decoction as in claim 1 , wherein the content of elenolic acid is comprised between about 600 mg/liter and about 1 claim 1 ,700 mg/liter.11. Decoction as in claim 1 , wherein the content of ...

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Номер записи: 59
05-05-2022 дата публикации

Solubilizate with curcumin and at least the cannabinoid thc as a further active substance

Номер: US20220133682A1
Автор: Dariush Behnam
Принадлежит: Aquanova AG

In order to make available the health-promoting and healing properties of curcumin and/or the cannabinoid THC to the human organism, the invention provides a solubilizate consisting of or comprising curcumin in a content equal to or less than 10 wt. %, and at least THC as at least one further active substance, as well as at least one emulsifier with an HLB value in a range below 18, preferably between 13 and 18, in particular polysorbate 80 or polysorbate 20 or at least one sucrose ester of edible fatty acids, and a solubilizate comprising, in particular consisting of at least one cannabinoid in a content of less than or equal to 10 wt. % and at least one emulsifier having an HLB value in a range of less than 18, preferably between 13 and 18, in particular polysorbate 80 or polysorbate 20 or at least one sucrose ester of edible fatty acids.

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Номер записи: 60
19-03-2020 дата публикации

Sterol composition in pumpkin seed oil and application thereof, and drug for treating benign prostatic hyperplasia

Номер: US20200085844A1
Автор: Dongbo LIU
Принадлежит: Hunan Zhongkewentai Bio Tech CoLtd

A sterol composition in pumpkin seed oil and an application thereof, and a drug for treating benign prostatic hyperplasia are provided, which relate to a technical field of medicine. The sterol composition in the pumpkin seed oil includes components by weight percentage of: 0.2-2 wt % cholesterol, 0.5-5 wt % campesterol, 1.5-5 wt % β-sitosterol, 15-40 wt % stigmasterol, 20-40 wt % ergosta-7,22-dien-3β-ol, 5-10 wt % lanosterol, and 15-30 wt % cholest-7-en-3β,5α-diol. The sterol composition in the pumpkin seed oil is a pumpkin phytosterol composition extracted from the pumpkin seed oil. Through combining the phytosterol components and controlling a proportion among the components, effects of alleviating and treating prostate diseases are achieved, especially for the benign prostatic hyperplasia.

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Номер записи: 61
19-06-2014 дата публикации

Solid/liquid extraction with a solvent comprising between 5 and 8 carbon atoms and 1 or 2 oxygen atoms

Номер: US20140171669A1
Автор: Alex Saunois, Eglantine Mercier, Jacques Legrand
Принадлежит: Laboratoires Expanscience SA

The present invention relates to a process for the solid/liquid extraction of a natural extract contained in at least one vegetable solid or micro-organism comprising at least the following steps: solid/liquid extraction of at least one vegetable solid or micro-organism by a first solvent system comprising a solvent content chosen from the solvents comprising between 5 and 8 carbon atoms and one or two oxygen atoms in ether function, or ketone function, or ester function form, of at least 50% by volume in relation to the total volume of the first solvent system, retrieval of a natural extract, notably comprising or consisting of an oil or a butter, particularly enriched with unsaponifiable.

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Номер записи: 62
12-05-2022 дата публикации

Cannabis inhalation products and methods of production thereof

Номер: US20220142970A1
Автор: AHARON Eyal, Noa Raz
Принадлежит: Buzzelet Development and Technologies Ltd

Provided is a solid homogeneous composition comprising at least one cannabinoid and a carrier having at least two of: (i) a total cannabinoid concentration greater than 5%; (ii) being in comminuted particle form, wherein at least 70 wt % of said particles are of size greater than 0.3 millimeter and less than 4.2 millimeters; (iii) comprising less than 20 wt % water; (iv) said carrier comprising cellulose; (v) said carrier comprises less than 50% by weight cannabis or hemp non-cannabinoid plant material, wherein said composition is suitable for providing cannabinoid via inhalation. Further provided are products comprising the composition, methods of use and methods of preparation thereof.

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Номер записи: 63
06-04-2017 дата публикации

Process for the Extraction of Strawberry P-Coumaroyl Hexose and/or Polyphenols, Extract and Uses Thereof

Номер: US20170095494A1
Автор: ANGERS Paul, Desjardins Yves, Dubé Pascal, Dudonne Stephanie, Gosselin Andre, LEONHART Sebastien, Marette Andre, PILON Genevieve
Принадлежит:

A composition of purified and biologically active p-coumaroyl hexose and/or polyphenols is provided by separation from strawberry's pulp by a method of extraction and purification using a hydrophobic adsorbent using GRAS solvent. Also provided is the use of the composition. 1. A strawberry fruit extract comprising at least 500 ppm of p-coumaryl hexose in dry matter.2. (canceled)3. The extract of claim 2 , comprising a concentration of p-coumaroyl hexose of at least 1000 ppm.4. (canceled)5. The extract of claim 4 , comprising a concentration of p-coumaroyl hexose of at least 4000 ppm.6. The extract of claim 1 , wherein said strawberry is of the Authentique Orleans variety.7. A strawberry extract having an ORAC value of at least about 1500 Trolox equivalent (μM/g).8. The strawberry extract of claim 7 , comprising about 5% to about 60% polyphenols.9. The extract of claim 8 , comprising about 30-40% ellagitanins; 20-30 proanthocyanidins; 5 to 10% pelargonidin; and 5-10% quercetin claim 8 , and 10% to 30% simple phenolics.10. The extract of claim 9 , wherein said simple phenolics comprises at least about 600 ppm of p-coumaryl hexose in dry matter.11. The extract of claim 1 , being in the form of a liquid or a powder.12. A composition comprising the extract according to claim 1 , in admixture with a physiologically acceptable excipient.13. A capsule or tablet for human oral administration comprising the composition according to in the form of a powder or a liquid.1415.-. (canceled)16. A process for the enrichment of p-coumaroyl hexose and/or polyphenols from a processed strawberry pulp claim 12 , the process comprising the steps of:a) suspending said pulp in a solvent selected from: ethanol, water and aqueous ethanol, at pH between 1.5 and 4.5 to obtain an ethanolic extract;b) evaporating said solvent and resuspending extract in water to obtain an aqueous extract;c) submitting said aqueous extract to a hydrophobic chromatography column;d) eluting said column with aqueous ...

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Номер записи: 64
12-04-2018 дата публикации

Method for making coffee products containing cannabis ingredients

Номер: US20180098552A1
Автор: Christopher Bhairam
Принадлежит: Imbue LLC

The present disclosure is directed to methods of making a coffee products containing cannabinoids that are extracted from Cannabis plant. According to one embodiment, the method includes the steps of (a) extracting cannabinoids from Cannabis plant; and (b) admixing the cannabinoids into a coffee product. The disclosed methods produce coffee products that possesses the benefits of both coffee and Cannabis plant. The methods can be used to produce different coffee products including single-serve coffee pods, ground coffee, and espresso. The methods are used to make coffee products with desired and consistent amount of tetrahydrocannabinol (THC).

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Номер записи: 65
12-04-2018 дата публикации

EXTRACTION DEVICES, SYSTEMS, AND METHODS

Номер: US20180099017A1
Автор: Jones Andrew
Принадлежит:

Extraction devices, methods, and systems are disclosed. Example devices have a solvent chamber, a plant material chamber, a collection chamber, and a solvent return that create a sealed, closed-cycle extraction and/or solvent purification process. Any extractable plant material can be used in the disclosed devices, methods, and systems although in some examples some form of the plant is used. 1. A cannabinoid extraction device , comprising:a solvent chamber having a solvent chamber return inlet, the solvent chamber structured to store a solvent having a stored solvent volume;a solvent chamber-cannabinoid containing plant material chamber interface having a first side and an opposing second side, the first surface attached to the solvent chamber and structured to receive solvent released from the solvent chamber;a cannabinoid containing plant material chamber attached to the second side of the solvent chamber-cannabinoid containing plant material chamber interface, the cannabinoid containing plant material chamber in fluid communication with the solvent chamber and structured to receive the solvent released from the solvent chamber, the cannabinoid containing plant material chamber structured to house cannabinoid containing plant material and to expose the received solvent to the cannabinoid containing plant material to produce a cannabinoid containing solvent-extract solution;a cannabinoid containing plant material chamber-collection chamber interface having a first side and an opposing second side, the first side attached to the cannabinoid containing plant material chamber and structured to receive the solvent-extract solution from the plant material chamber;a collection chamber attached to the second side of the cannabinoid containing plant material chamber-collection chamber interface, the collection chamber in fluid communication with the cannabinoid containing plant material chamber and structured to receive the cannabinoid containing solvent-extract solution ...

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Номер записи: 66
12-04-2018 дата публикации

EXTRACT FROM INDIGO NATURALIS AND A PROCESS FOR PREPARING THE SAME

Номер: US20180099020A1
Автор: Andres Philippe, BILY Antoine, Cardinaud Isabelle, CHANTALAT Laurent, Le Bronec Loïc, LIN Yin-Ku, Pierson Jean-Thomas
Принадлежит:

The present invention relates to a process for preparing an extract from one or more botanical raw materials, such as Indigo Naturalis and the extract itself. The present invention also relates to a composition comprising the extract, as well as the use of composition in medical or cosmetic applications. 1. An extract product of Indigo Naturalis prepared by a process comprising:a) extracting the Indigo Naturalis with a solvent to obtain a mixture of extraction, wherein the solvent is selected from the group consisting of dimethylformamide, ethyl acetate, ethanol, dimethylsulfoxide, dichloromethane, tetrahydrofuran, dimethylacetamide, acetone, 2-butanone, acetonitrile, isopropyl acetate, 2-methyl tetrahydrofuran, methyl tert-butyl ether, methanol, chloroform, terpene, water and a combination thereof,b) filtering the mixture of extraction to obtain a filtrate,c) concentrating the filtrate to obtain a crude extract,d) mixing the crude extract and hexane or heptane in reflux to obtain a first washing mixture,e) cooling and filtering the first washing mixture at room temperature obtain a first extract product, and i. mixing the first extract product and a solvent selected from the group consisting of hexane, ethanol and an aqueous solution of ethanol in reflux to obtain a second washing mixture, and', 'ii. cooling and filtering the second washing mixture at room temperature to obtain the extract product of Indigo Naturalis., 'f) washing the first extract product with a washing method comprising2. The extract product of Indigo Naturalis of claim 1 , wherein in a) claim 1 , the solvent is selected from the group consisting of dimethylformamide claim 1 , ethyl acetate claim 1 , ethanol claim 1 , and a combination thereof claim 1 , or an aqueous solution thereof.3. The extract product of Indigo Naturalis of claim 2 , wherein in a) claim 2 , the solvent is ethyl acetate claim 2 , ethanol or an aqueous solution of ethanol claim 2 , and the mixture of extraction is obtained by ...

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Номер записи: 67
04-04-2019 дата публикации

LIPID COMPRISING LONG CHAIN POLYUNSATURATED FATTY ACIDS

Номер: US20190100485A1
Автор: de Feyter Robert Charles, Devine Malcolm David, McAllister Jason Timothy, Petrie James Robertson, Shrestha Pushkar, Singh Surinder Pal
Принадлежит:

The present invention relates to extracted plant lipid or microbial lipid comprising docosahexaenoic acid, and/or docosapentaenoic acid, and processes for producing the extracted lipid. 1. Extracted plant lipid , comprising fatty acids in an esterified form , the fatty acids comprising oleic acid , palmitic acid , ω6 fatty acids which comprise linoleic acid (LA) , ω3 fatty acids which comprise α-linolenic acid (ALA) and docosahexaenoic acid (DHA) , and optionally one or more of stearidonic acid (SDA) , eicosapentaenoic acid (EPA) , docosapentaenoic acid (DPA) and eicosatetraenoic acid (ETA) , wherein the level of palmitic acid in the total fatty acid content of the extracted lipid is between about 2% and 16% , and wherein the level of myristic acid (C14:0) in the total fatty acid content of the extracted lipid , if present , is less than 1% , and wherein the level of DHA in the total fatty acid content of the extracted lipid is between 20.1% and 35%.2. The extracted plant lipid of which has one or more of the following featuresi) the level of palmitic acid in the total fatty acid content of the extracted plant lipid is between about 2% and 15%, or between about 3% and about 10%,ii) the level of myristic acid (C14:0) in the total fatty acid content of the extracted plant lipid is about 0.1%,iii) the level of oleic acid in the total fatty acid content of the extracted plant lipid is between about 1% and about 30%, between about 3% and about 30%, between about 6% and about 30%, between 1% and about 20%, between about 30% and about 60%, about 45% to about 60%, about 30%, or between about 15% and about 30%,iv) the level of linoleic acid (LA) in the total fatty acid content of the extracted plant lipid is between about 4% and about 35%, between about 4% and about 20%, between about 4% and about 17%, or between about 5% and about 10%,v) the level of α-linolenic acid (ALA) in the total fatty acid content of the extracted plant lipid is between about 4% and about 40%, ...

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Номер записи: 68
23-04-2015 дата публикации

Composition containing an essential oil product and method for using such to maintain normal levels of testosterone

Номер: US20150110909A1
Автор: D. Gary Young
Принадлежит: Young Living Essential Oils LC

A composition useful for maintaining healthy levels of testosterone in men and women. The composition includes essential oils from a tree of the genus Picea or a product of this oil. The essential oil product can specifically come from essential oil from the plant Picea pungens , commonly referred to as Blue Spruce. Also disclosed is a method for maintaining healthy levels of testosterone in men and women utilizing the composition. In some implementations, the composition is a pharmaceutical composition that further includes a penetration enhancer. A method for utilizing the pharmaceutical composition for treating hypogonadism is also disclosed.

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Номер записи: 69
09-06-2022 дата публикации

Use of green coffee based compositions for improving insulin profile

Номер: US20220175864A1
Автор: Christian Chabert, Jacklyn Ruilin Chen, Lucas Actis Goretta, Marine KRAUS, Rachid Bel-Rhlid, Robin Willows
Принадлежит: SOCIETE DES PRODUITS NESTLE SA

The present invention relates to a green coffee-based composition comprising hydrolysed chlorogenic acid for use in the treatment or prevention of a disorder linked to an increase in plasma postprandial insulin in a subject. The invention relates also to the non-therapeutic use of a composition comprising an esterase treated decaffeinated green coffee extract with an amount of 40-200 mg administered to a subject per day to decrease plasma postprandial insulin concentration. A further aspect of the invention is a process for forming green coffee based compositions.

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Номер записи: 70
26-04-2018 дата публикации

EXTRACT FOR TREATING SKIN CONDITIONS

Номер: US20180110815A1
Автор: Drake Karen
Принадлежит:

Some embodiments of the present disclosure include a therapeutic extract for selectively treating skin disorders, such as acne and rosacea. The therapeutic extract may include glycerin; water, such as reverse osmosis water; blackcurrant; pine; gluconolactone; citric acid; and sodium benzoate. In embodiments, the blackcurrant may be organic ribes nigrum and may be derived from fruit of a blackcurrant plant. Moreover, the pine may be spp and may be derived from a needle of a pine plant. 1. A therapeutic extract for selectively treating skin disorders , the therapeutic extract comprising:glycerin;water;blackcurrant;pine;gluconolactone;citric acid; andsodium benzoate.2. The therapeutic extract of claim 1 , wherein the blackcurrant comprises organic ribes nigrum and is derived from fruit of a blackcurrant plant.3pinus. The therapeutic extract of claim 1 , wherein the pine comprises spp and is derived from a needle of a pine plant.4. The therapeutic extract of claim 1 , comprising:about 15 to about 40 wt % glycerin;about 20 to about 30 wt % water;about 10 to about 30 wt % blackcurrant;about 10 to about 30 wt % pine;about 0.10 to about 1.00 wt % gluconolactone;about 0.10 to about 0.50 wt % citric acid; andabout 0.10 to about 0.20 wt % sodium benzoate.5. The therapeutic extract of claim 4 , wherein the therapeutic extract comprises:about 30 wt % glycerin;about 29.2 wt % water;about 20 wt % blackcurrant;about 20 wt % pine;about 0.45 wt % gluconolactone;about 0.2 wt % citric acid; andabout 0.15 wt % sodium benzoate.6. The therapeutic extract of claim 1 , wherein the extract comprises an equal amount of blackcurrant and pine.7. A method of producing a therapeutic extract for selectively treating skin disorders claim 1 , the method comprising:preparing dry botanicals;preparing an extraction solvent;extracting blackcurrant and pine;creating the therapeutic extract;pasteurizing the therapeutic extract;preserving the therapeutic extract; andoptionally, packaging the therapeutic ...

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Номер записи: 71
09-04-2020 дата публикации

Medicinal Composition of Amaranth Extract Origin Having Enriched Nitrate Content and a Method of Preparing the same

Номер: US20200108110A1
Автор: Antony Benny
Принадлежит:

An extract of Amaranth, having enriched nitrate content, L-arginine, Flavonoids, saponins, alkaloids, carbohydrates, proteins, potassium, and with negligible amount of oxalic acid or oxalate content. The extract of Amaranth can be prepared from fresh or dried leaves and stem of Amaranth. Dosage forms of extract include fast melt tablet, lozenge, candy, chewing gum, beverage, tablet, capsule, pill, and powder. The extract of Amaranth enhances nitric oxide concentration, enhances nitrate level concentration, and enhances nitrite level in blood as well as in saliva. Administering the extract can lower blood pressure, increase physical endurance, increase swimming endurance, increase running endurance, and improve sexual performance among human beings. 1. An extract of Amaranth , the extract comprisingabout 0.1% to about 20% nitrates;about 0.1% to about 10% of L-arginine;about 0.001% to about 10% of flavonoids;about 0.01% to about 15% of saponins;about 0.01% to about 10% of alkaloids;about 10% to about 30% of carbohydrates;about 5% to about 25% of proteins;about 5% to about 25% potassium; and,about 0.01% to about 50% of total oxalic acid, wherein the total oxalic acid comprises free oxalic acid and oxalates.2. The extract of Amaranth of further comprising Vitamin C.3Amaranthus caudatus, Amaranthus cruentus, Amaranthus tricolor, Amaranthus blitum, Amaranthus viridis, Amaranthus dubius. The extract of Amaranth of claim 1 , wherein the Amaranth is selected from the group consisting of and combinations thereof.4. The extract of Amaranth of comprisingabout 3% to about 20% nitrates;about 1% to about 10% of L-arginine;about 1% to about 10% of flavonoids;about 5% to about 15% of saponins;about 3% to about 10% of alkaloids;about 10% to about 30% of carbohydrates;about 5% to about 25% of proteins;about 1% to about 5% of potassium; and,about 0.1% total oxalic acid, wherein the total oxalic acid comprises free oxalic acid and oxalates.5. A dosage form comprising the extract of ...

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Номер записи: 72
17-07-2014 дата публикации

Herpes treatment

Номер: US20140199418A1
Автор: Behnam Azizkhani
Принадлежит: Individual

Herpes infections in hum an patients can be treated with injections of garlic juice. The garlic juice is produced by cutting, crushing, or otherwise damaging garlic cloves, and collecting the juice. This garlic juice is dissolved in a carrier solution, such as water or saline, and then injected into the patient.

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Номер записи: 73
25-08-2022 дата публикации

MULTIFUNCTIONAL EXTRACTS OF SUGARCANE STRAW OR BAGASSE AND USES THEREOF

Номер: US20220264913A1
Автор: DA SILVA OLIVEIRA Ana Lúcia, ESTEVEZ PINTADO Maria Manuela, MENDES FERREIRA MONTEIRO MADUREIRA Ana Raquel
Принадлежит:

Provided herein are extracts of sugarcane straw or bagasse, methods of preparing the extracts, and the use of the extracts in compositions that have antioxidant activity, anti-inflammation activity, and antimicrobial activity that can be used as multifunctional ingredients. Further provided are methods of using the extracts to treat or ameliorate conditions involving oxidation, inflammation, skin and food enzymes inhibition activity capacity and microbial growth. 1. A method of preparing an extract from sugarcane bagasse or sugarcane straw comprising:obtaining a dried sugarcane bagasse or a dried sugarcane straw;milling the dried bagasse or the dried straw;mixing the milled bagasse or straw with a solution comprising a solvent to form a mixture;stirring the mixture;separating a liquid fraction and a solid fraction of the mixture;concentrating the liquid fraction to obtain an extract; andoptionally drying the liquid fraction to obtain a dry extract.2. The method of claim 1 , wherein the bagasse or the straw are dried at a temperature not less than 30° C.3. The method of claim 1 , wherein the dried bagasse or the dried straw is milled to a size ranging from 2 mm to 4 mm.4. The method of claim 1 , wherein the solvent is selected from the group consisting of: acetone claim 1 , dichloromethane claim 1 , ethanol claim 1 , methanol claim 1 , and combinations thereof.5. The method of claim 1 , wherein the solution comprising the solvent comprises ethanol.6. The method of claim 1 , wherein the mixture is stirred for at least 24 hours.7. The method of claim 1 , wherein the mixture is stirred at a temperature ranging from 20° C. to 22° C.8. The method of claim 1 , wherein the liquid fraction and the solid fraction are separated by filtration.9. An extract obtained by the method of .10. (canceled)11. (canceled)12. The extract of claim 9 , wherein the extract inhibits or reduces skin enzymes activity.13. The extract of claim 9 , comprising from about 2% (wt/wt) to 8% (wt/wt) ...

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Номер записи: 74
04-05-2017 дата публикации

Method for preparing garlic-fermented composition and garlic-fermented composition prepared by same method

Номер: US20170119839A1
Автор: Hyun Soo CHUN
Принадлежит: Individual

The present invention relates to a method for preparing a garlic-fermented composition and a garlic-fermented composition prepared by the method, and the purpose of the present invention is to provide a garlic-fermented composition which is easy to take, has no side effect, and improves excellent pharmacological and physiological efficacies of garlic. To achieve this, the method for preparing a garlic-fermented composition according to an aspect of the present invention, comprises: a first fermentation step of mixing garlic, water, and a ferment strain, followed by fermentation, thereby decomposing and converting sugars and proteins of the garlic; and a second fermentation step of additionally supplying a carbon source to a filtrate obtained through solid-liquid separation of the fermented product, followed by fermentation, thereby removing ammonia of the filtrate and decomposing and converting the additionally supplied carbon source.

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Номер записи: 75
27-05-2021 дата публикации

Cannabis Plant Extracts with Butane

Номер: US20210154596A1
Автор: James Castillo
Принадлежит: Jennys Rose LLC

The present invention is a process for producing various types of cannabis extract from harvested cannabis. A quantity of harvested cannabis, which typically includes the inflorescence, floral leaves, and small stems of a flowering cannabis plants, is pre-frozen and is first subjected to cryogenic grinding to produce pulverized cannabis. The pulverized cannabis is then subjected to butane extraction at a low temperature to produce an initial cannabis extract. The butane in the initial cannabis extract is removed by evaporating it from the mixture in a cold vacuum chamber. The process preserves desirable waxes and lipids and removes the butane from the extract without subjecting the extract to heating in order to preserve the integrity of the terpenoids and flavonoids in the extract.

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Номер записи: 76
10-05-2018 дата публикации

FORMULATIONS FOR THE TREATMENT AND PREVENTION OF OBESITY

Номер: US20180125918A1
Автор: Bombardelli Ezio, Corti Fabrizio
Принадлежит: INDENA S.P.A.

Disclosed are compositions containing: 1. Compositions comprising:{'i': 'Phaseolus vulgaris;', 'a) extract of'}{'i': 'Cynara scolymus;', 'b) extract of'}{'i': 'Echinacea angustifolia;', 'c) extract of'}{'i': 'Vitis vinifera;', 'd) extract of'}and optionally{'i': 'Panax ginseng;', 'e) extract of'}mixed with suitable excipients.2. Compositions according to in the form of tablets claim 1 , dragées claim 1 , soft or hard gelatin capsules or cellulose capsules.3Phaseolus vulgaris. Compositions according to wherein the extract of has an α-amylase inhibitor content of 300 μg/mg and a lectin value of 10000 U/mg.4Cynara scolymus. Compositions according to wherein the extract of has a caffeoylquinic acid content ranging between 20 and 70% claim 1 , preferably 35%.5Panax ginseng. Compositions according to wherein the extract of has a ginsenoside content of 7% determined by HPLC.6Phaseolus vulgaris,Cynara scolymus,Echinacea angustifoliaVitis vinifera. Compositions according to containing 100 mg of extract of 50 to 200 mg of an extract of 25 mg of extract of and 200 mg of extract of pips.7Panax ginseng.. Compositions according to claim 6 , also containing 40 mg of extract of This U.S. non-provisional application is a divisional application of U.S. application Ser. No. 14/433,179 filed on Apr. 2, 2015, which is U.S. national stage of PCT/EP2013/071138 filed on 10 Oct. 2013, which claims priority to and the benefit of Italian Application No. MI2012A001727 filed on 12 Oct. 2012, the contents of which are all incorporated herein by reference in their entireties.The present invention relates to combinations of medicinal plant extracts useful in the prevention and treatment of obesity and excess weight.Excess weight and obesity are rising to a worrying extent in all the industrialised countries, and may affect up to 50% of the population in the next decade. Obesity affects the health of the sufferer, with adverse effects on the cardiovascular, musculoskeletal and gastrointestinal ...

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Номер записи: 77
10-05-2018 дата публикации

Extraction of resveratrol from waste biomass derived from grapes processing

Номер: US20180127342A1
Автор: Kieu Hoang
Принадлежит: Individual

The invention describes the extraction method to obtain the highest amount of resveratrol from wasted biomass produced by grapes processing. Resveratrol, which is found rich in the grapes, especially in grape skin and seed, is one of the most potent antioxidant, and can help to fight cell-damaging free radicals and promote cardiovascular health. Based on the most performing extraction methods to obtain resveratrol from plant material, the invention provides the optimized method of extracting the highest amount of resveratrol from wasted biomass from grapes processing.

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Номер записи: 78
23-04-2020 дата публикации

Cannabis formulation and method of preparation

Номер: US20200121748A1
Автор: Dorian Orion Guerrazzi, Tommy John Guerrazzi
Принадлежит: Purity Agritech Corp

Cannabis formulations and method of preparing the cannabis formulations. A phytocannabinoid preparation, such as an extract or distillate, is heated to a setpoint temperature at which the phytocannabinoid preparation is flowable. The setpoint may be between 90 and 105° F. A carrier oil is combined with the phytocannabinoid preparation. High-shear mixing is applied to the carrier oil and the phytocannabinoid preparation to provide a diluted preparation. Lecithin is combined with the diluted preparation and additional high-shear mixing is applied the lecithin with the diluted preparation, providing a cannabis formulation. The cannabis formulation may be cavitated with ultrasonic mixing. The cannabis formulation may be combined with maltodextrin to provide a solid phytocannabinoid formulation.

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Номер записи: 79
03-06-2021 дата публикации

Vaporized Medicants and Methods of Use

Номер: US20210161984A1
Автор: Bartkowski William P., Chong Alexander ChinHak, Thompson Marshall A.
Принадлежит:

A method and formulation for delivering a motion sickness antidote in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the motion sickness antidote. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer. 1. A method for delivering medicants through inhalation , comprising: i) an excipient comprising propylene glycol present at approximately 1 percent to approximately 30 percent of the excipient, vegetable glycerin present at approximately 1 percent to approximately 30 percent of the excipient, water present at approximately 0.01 percent to approximately 30 percent of the excipient, and alcohol present at approximately 0.01 percent to approximately 30 percent of the excipient, and', 'ii) diphenhydramine; and, 'a) acquiring a medicant solution suitable for vaporization, the medicant solution, comprisingb) vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the medicant solution is provided to a user for inhalation.2. The method of claim 1 , wherein the step of vaporizing the medicant solution comprises using a vaporizer.3. method for delivering medicants through inhalation claim 1 , comprising: i) an excipient comprising an inert non-reactive compound, and', 'ii) a motion sickness antidote; and, 'a) acquiring a medicant solution suitable for vaporization, the medicant solution, comprisingb) vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C.4. The method of claim 2 , wherein the step ...

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Номер записи: 80
19-05-2016 дата публикации

Composition containing composite extract of rehmannia glutinosa and pueraria lobata for preventing or treating menopausal symptoms

Номер: US20160136217A1
Автор: Aihong KIM, Hocheol Kim, Juyeon Park, Mikyung Song, Sung Hyun Lee
Принадлежит: Industry Academic Cooperation Foundation of Kyung Hee University

The present invention relates to a composition and functional health food containing a composite extract of Rehmannia glutinosa and Pueraria lobata for preventing or treating menopausal symptoms; and a method for preventing or treating menopausal symptoms by administering the composite extract. The composite extract of Rehmannia glutinosa and Pueraria lobata of the present invention can ameliorate weight increase, which is the representative symptom of menopausal women, and can effectively improve osteoporosis and blood cholesterol. Thus, the composition can be useful as a pharmaceutical composition or functional heath food for preventing or treating menopausal symptoms, and can be used in preventing or treating menopausal symptoms.

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Номер записи: 81
03-06-2021 дата публикации

Continuous biomass extraction system and process

Номер: US20210162315A1
Автор: Amara HAZLEWOOD, Steve JAASUND, Steven E. Bonde
Принадлежит: Boulder Creek Technologies LLC

A method for producing valuable organic liquid from a biomass wherein a gas is heated to a predetermined temperature to produce a heated gas. The heated gas is mixed with a biomass to produce an enriched organic vapor and a biomass waste product. The biomass waste product is separated from the enriched organic vapor. The enriched organic vapor is cooled to produce a liquid organic oil and the liquid organic oil is collected. A system for producing the liquid organic oil wherein the system includes a heat source for heating a gas to produce a heated gas and a first separation unit to separate an enriched organic vapor and a biomass waste product. The enriched organic vapor and the biomass waste product are generated from mixing the heated gas and a biomass. The system also includes a wet scrubber for cooling the enriched organic vapor to remove certain compounds from the enriched organic vapor to generate an enriched organic smoke. The organic smoke can be transformed to the liquid organic oil in an electrostatic precipitator.

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Номер записи: 82
17-05-2018 дата публикации

USE OF TRADITIONAL CHINESE MEDICINE COMPOSITION IN PREPARATION OF POTASSIUM ION CHANNEL MODULATOR MEDICINE

Номер: US20180133279A1
Автор: Mao Peng, WANG Baoan
Принадлежит:

The present invention provides an application of a combination of traditional Chinese medicine in the preparation of a potassium ion channel modulating agent. The combination of traditional Chinese medicine is made up of traditional Chinese medicine raw materials according to the following weight proportion: 3. According to claim 1 , an application of a combination of traditional Chinese medicine in the preparation of a potassium ion channel modulating agent claim 1 , Wherein claim 1 , the combination of traditional Chinese medicine is prepared by the following method claim 1 , and the method comprises the following steps:{'i': Aurantii', 'Ginseng, '(1) The foreign matters and non medicinal parts are picked out from Artemisiae Annuae Herba, Sophorae Flavescentis Radix, Glycyrrhizae Radix Et Rhizoma, Poria, Coptidis Rhizoma, Fructus Immaturus, Dichroae Radix, Radix Et Rhizoma, Pinelliae Rhizoma, Ophiopogonis Radix, and Nelumbinis Plumula, respectively, and then set aside until use;'}{'i': Aurantii', 'Ginseng, '(2) The foreign matters and non medicinal parts are picked out from Artemisiae Annuae Herba, Sophorae Flavescentis Radix, Glycyrrhizae Radix Et Rhizoma, Poria, Coptidis Rhizoma, Fructus Immaturus, Dichroae Radix, Radix Et Rhizoma, Pinelliae Rhizoma, respectively, and then rinsed with flowing water and cut into slices or segments; Ophiopogonis Radix is moistened with a flowing water then crashed as flate and set aside until use;'}(3) The crude drugs of steps (1) and (2) are dried at 70˜80° C. and set aside until use;{'i': 'Aurantii', '(4) Coptidis Rhizoma, Fructus Immaturus, Dichroae Radix, Nelumbinis Plumula and Sophorae Flavescentis Radix are extracted by reflux with 60% ethanol for two times, add eight times amount of solvent for the first time and six times for the second time, 1.5 h for each time. Combined the extracts, filtrated, and the filtrate is concentrated in vacuum at 0.04 Kpa and recovered ethanol at 70° C., continued to condense to obtain thick ...

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Номер записи: 83
18-05-2017 дата публикации

Pharmaceutical composition containing spirulina maxima extract as active ingredient for preventing and treating retinal diseases

Номер: US20170136075A1
Автор: Do Hyung Kang, Dong Joon Kim, Sang Ho Choi, Se Young Choung, Seung Won Yang, Soo Jin Heo
Принадлежит: Jcreation

A Spirulina maxima extract of the present invention and Allophycocyanin (APC), R-phycoerythrin (R-PE), and C-phycocyanin (C-PC), which are components of the Spirulina maxima extract, show an effect of inhibiting cell death and A2E (pyridinium bis-retinoid), oxidation due to blue light, and therefore can be usefully applied as an active ingredient in a composition for preventing and treating retinal disease.

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Номер записи: 84
08-09-2022 дата публикации

PHARMACEUTICAL COMPOSITION AND METHOD OF MANUFACTURING

Номер: US20220280582A1
Автор: Speier Gary J.
Принадлежит:

The present invention provides for methods of obtaining an extract of plant material as well as subsequent processing of the extract to provide a concentrate of The present invention also provides for pharmaceutical dosage forms (e.g., oral thin films and transdermal patches) that include the concentrate (or extract) of as well as methods of medical treatment that include administering the pharmaceutical dosage forms. 1Cannabis,{'sub': '2', 'i': 'Cannabis;', '(a) contacting cannabis with carbon dioxide (CO) as the sole supercritical fluid solvent, at a pressure of at least 74 bar and at a temperature of at least 31° C., for a period of time of up to about 8 hours, to provide an extract of'}{'i': 'Cannabis;', '(b) repeating, one or more times, step (a), to obtain multiple extracts of'}{'i': 'Cannabis;', '(c) removing the supercritical fluid solvent from multiple extracts of and'}{'i': Cannabis', 'Cannabis,', 'Cannabis, '(d) isolating cannabinoids from one of the extracts of and isolating terpenes from another extract of to yield (i) an extract of enriched with cannabinoids and (ii) an extract of cannabis enriched with terpenes.'}. A process for obtaining one or more extracts of the process comprising: This application is a continuation of U.S. application Ser. No. 14/723,980, filed May 28, 2015, which is a continuation-in-part (CIP) of U.S. application Ser. No. 14/694,303, filed on Apr. 23, 2015, which is a continuation of U.S. application Ser. No. 14/255,296, filed on Apr. 17, 2014; the contents of which arc incorporated by reference herein in their entirety.The medicinal and psychoactive properties of the plant have been known for centuries. At present, is not legally available in many States. However, there is growing pressure on politicians to legalize its use, especially for medicinal purposes.Evidence suggests that is a safe, versatile and potentially inexpensive drug. It has been reported as being beneficial to patients suffering from a wide range of symptoms ...

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Номер записи: 85
08-09-2022 дата публикации

Composition for ameliorating premenstrual syndrome symptoms, including chrysanthemum zawadskii extract

Номер: US20220280583A1
Автор: Da Eun Lee, Jeong Eun Kwon, Se Chan Kang, Yong Joon Jeong
Принадлежит: Genencell Co Ltd

The present invention relates to a composition which is for preventing and ameliorating or treating premenstrual syndrome symptoms, and includes: (a) a Chrysanthemum zawadskii extract; (b) a mixture of the Chrysanthemum zawadskii extract and a malt extract; or (c) a mixture of the Chrysanthemum zawadskii extract, the malt extract, and an aloe extract. Specifically, the present compositions effectively inhibit the secretion of prolactin from pituitary cells, which is a phenomenon that appears during premenstrual syndrome, thereby increasing the secretion of progesterone, which is reduced during the luteal phase of women, and can thus be advantageously used as a composition for preventing and ameliorating or treating women's premenstrual syndrome.

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Номер записи: 86
15-09-2022 дата публикации

PROTEIN-ENRICHED TOBACCO-DERIVED COMPOSITION

Номер: US20220287356A1
Автор: Bratcher Barry, Debusk Samuel Mark, Ford Kyle, Hagan Leigh, Joyce Leigh Ann Blevins, Lovette Margarette Elisa, Morton Joshua D., Mua John-Paul
Принадлежит:

The present disclosure describes methods of obtaining and/or deriving proteins from plants of the species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight. 1Nicotiana. A method for obtaining a protein-enriched material from a plant of the species or portion thereof , comprising:{'i': 'Nicotiana', 'receiving a plant material of the species;'}contacting the plant material with a solvent for a time and under conditions sufficient to extract one or more proteins from the plant material into the solvent and form a liquid protein-containing extract;separating a solid extracted plant material from the liquid protein-containing extract;clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; andtreating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by dry weight.26. The method of claim 1 , wherein the treating step comprises adjusting the pH of the clarified protein-containing extract to a pH of less than about to form an acidic extract;isolating a precipitate from the acidic extract; andwashing the precipitate to provide a protein-enriched material.3. The method of claim 2 , wherein the pH of the clarified protein-containing extract is adjusted to a pH of between about 4.5 to about 6 to provide a RuBisCO-containing ...

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Номер записи: 87
02-06-2016 дата публикации

Pharmaceutical composition adjuvant to chemotherapy drugs and applications thereof

Номер: US20160151435A1
Автор: Chia-Chi Lin, Chien-Liang Kuo, Feng-Yue Weng, Wen-Huang Liu
Принадлежит: Balay Biotechnology Corp

The present invention discloses a pharmaceutical composition and applications thereof. The pharmaceutical composition comprises an extract of Antrodia cinnamomea fruiting bodies and a pharmaceutical carrier. The extract is fabricated via soaking the powder of Antrodia cinnamomea fruiting bodies in hot water and then undertaking extraction with a low-polarity solvent to acquire the extract from the soaked powder. The pharmaceutical composition can function as an adjuvant drug of chemotherapy drugs to enhance the treatment effect of the chemotherapy drugs cisplatin and gemcitabine and relieve the chemotherapy drug-induced side-effects of hair loss, muscle degradation and atrophy, gastrointestinal lesion, nephritis and renal injury.

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Номер записи: 88
15-09-2022 дата публикации

Extracts of coprinus comatus and their use for regulating the pilosebaceous unit in a human

Номер: US20220288145A1
Автор: Lorenzo Zanella, Paolo Pertile
Принадлежит: SYMRISE AG

Suggested is an extract of Coprinus comatus obtained or obtainable according to the following protocol: (a) providing a source of dry biomass of Coprinus comatus ; (b) extracting said source of biomass with water, C 1 -C 4 aliphatic alcohols or mixtures thereof; (c) separating the extract thus obtained from the remaining cell material; and optionally (d) repeating steps (b) and (c) once or twice, which is particularly useful for regulating the pilosebaceous unit of a human.

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Номер записи: 89
07-05-2020 дата публикации

LIQUID CARBON DIOXIDE BOTANICAL EXTRACTION SYSTEM

Номер: US20200138774A1
Автор: Sorbo Nelson W., Turner Jon R., Wikstrom Jon
Принадлежит:

A process for extracting a botanical organic compound from cannabis with subcritical liquid carbon dioxide includes providing a pressurizable extraction vessel. The cannabis is placed within the pressurizable extraction vessel, whereupon the extraction vessel is filled with liquid carbon dioxide under subcritical conditions. The cannabis is then allowed to be in contact with the subcritical liquid carbon dioxide for a selected period of time so as to extract at least a portion of the botanical organic compounds from the cannabis into the subcritical liquid carbon dioxide. The subcritical liquid carbon dioxide containing the botanical organic compound is then removed from the extraction vessel, and the liquid carbon dioxide is separated from the botanical organic compound. 1. A process for extracting a botanical organic compound from cannabis with sub-critical liquid carbon dioxide , the process comprising:providing a pressurizable extraction vessel;placing the cannabis within the pressurizable extraction vessel;filling the extraction vessel with liquid carbon dioxide under subcritical conditions;allowing the cannabis to be in contact with the subcritical liquid carbon dioxide so as to extract at least a portion of the botanical organic compounds from the cannabis into the sub-critical liquid carbon dioxide;removing from the extraction vessel the subcritical liquid carbon dioxide containing the botanical organic compound extracted from the cannabis; andseparating the liquid carbon dioxide from the botanical organic compound.2. The process of and further comprising adding ethanol to the liquid carbon dioxide.3. The process of wherein the botanical organic compound is a cannabinoid.4. The process of wherein the botanical organic compound is an essential oil.5. The process of wherein placing the cannabis within the permeable container comprises:providing a permeable container;placing the cannabis within the permeable container; andplacing the permeable container ...

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Номер записи: 90
31-05-2018 дата публикации

Method for preparation of a cannabinoid extract from hemp

Номер: US20180147247A1
Автор: Ervin Milenov IVANOV
Принадлежит: "Pobelch - Gle" Ood

The invention relates to a method for extraction and separation of cannabinoids from industrial hemp, designed for medicinal purposes, and also the preparation of an extract, not containing tetrahydrocannabinol, and the preparation of maximum refined individual cannabinoids. The advantage of the method according to the invention consists in the preparation of an extract from hemp, which contains at a high percentage medically useful cannabinoids and doesn't contain undesirable admixtures and tetrahydrocannabinol, so that it can be used without any restrictions as a pharmaceutical. Moreover, the method allows the possibility of separation, if required, into individual useful cannabinoids as pure compounds, in ecological terms, without environmental pollution, as it is according to the most synthetic methods. The possibility of producing pure compounds represents a great contribution to the research of substances, related to a concrete medical application and the preparation of various combinations thereof, with the objective of expansion the field of application. The method is also cost-effective. The method consists in that the extract, obtained in accordance with various methods, undergoes a centrifugal countercurrent liquid-liquid chromatography, as the operation includes a centrifugation of solvents and the extract, obtained during the previous operations; the solvents form two phases, the phase, which the extract is dissolved in, is mobile, and the other one is stationary, whereby the mobile phase passes through the stationary phase, wherein several amounts of the components of the extract content are captured; this passing of the mobile phase through the stationary phase is repeated many times, until separation of the desired substances, which are analyzed in a familiar way, whereby as stationary phase solvents are used, which are selected from the group of straight-chain and branched-chain hydrocarbons, produced from crude oil, straight-chain and/or ...

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Номер записи: 91
09-06-2016 дата публикации

ISOLATION OF NOVEL BIOACTIVE COMPOUND OBTAINED FROM OIL PALM BASE MATERIALS

Номер: US20160158265A1
Автор: JABARIAH Md Ali, Rha ChoKyun, Sambanthamurthi Ravigadevi, Sinskey Anthony J., Tan Yew Ai, TG Sambandan, WAN Saridah Wan Omar, YANG Meng Fei
Принадлежит: Malaysian Palm Oil Board

Present invention relates to a composition comprising novel bioactive compound obtained from oil palm based materials and the method of isolating bioactive compound thereof, wherein said compound is an indolacetic acid derivative. The compound is having at least one variation of moiety. 1. A composition comprising a bioactive compound obtained from oil palm based materials , wherein said compound is an indolacetic acid derivative.3. The composition as claimed in wherein said compound having at least one variation of moiety (X).4. The composition as claimed in wherein said moiety is from a hydroxyl group.5. The composition as claimed in wherein said moiety is a hydroxide molecule (—OH).6. The composition as claimed in wherein said moiety is from an amide group.7. The composition as claimed in wherein said moiety is an amidogen molecule (—NH).8. The composition as claimed in wherein said compound comprising two variations of moiety in bioactive compounds in the ratio of 1:1.9. The composition as claimed in wherein said bioactive compound is extracted from palm oil based wastes.10. The composition as claimed in wherein said bioactive compound is extracted from oil palm vegetation liquor.11. The composition as claimed in wherein said bioactive compound is extracted from palm oil mill effluent.12. The composition as claimed in is useful for providing bioactive properties.13. A method of isolating bioactive compound obtained from oil palm based material comprising the steps of:extracting said oil palm based material for oil palm phenolics (OPP),preparing compound for HPLC analysis,subjecting compound to HPLC analysis, andisolating compound for fraction of interest.14. The method of isolating bioactive compound as claimed in further comprising the step of subjecting said fraction to analytical HPLC analysis.15. The method of isolating bioactive compound as claimed in wherein said step of subjecting said fraction to analytical HPLC analysis further comprising the step of ...

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Номер записи: 92
09-06-2016 дата публикации

Method of extracting flavonoids and/or polyphenols from dried and powdered citrus peels, compositions therefrom, and methods of treatment of diseases associated with chronic inflammation

Номер: US20160158303A1
Автор: Andrew Tait, Harish Vasudevan
Принадлежит: Tait Laboratories Inc

Improved processes for extracting polyphenols and/or flavonoids from citrus peels are provided that comprise 1) heating a ground peel to form a pre-treated, ground peel; and 2) extracting the compounds of interest from the pre-treated, ground peel using a basic solution of pH greater than 7 and less than 12. Such processes serve to increase the efficiency of extraction of the polyphenols and/or flavonoids. In preferred embodiments, the flavonoids extracted include hesperidin and narirutin. These extracts are useful in the preparation of anti-inflammatory medicaments for the treatment of chronic inflammatory disorders such as inflammatory bowel disease, Crohn's disease, irritable bowel syndrome (IBS), and multiple sclerosis.

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Номер записи: 93
22-09-2022 дата публикации

Compositions and methods of producing de-flavored peppercorn

Номер: US20220296666A1
Автор: Alexandra Marcela HERRMANN, Swetha MAHADEVAN
Принадлежит: Brightseed Inc

Disclosed herein are compositions and methods for de-flavoring a peppercorn, whole or ground, that minimize piperine, a naturally occurring alkaloid imparting pungency, that minimize volatile oils imparting aroma, and that retain most of the naturally occurring metabolic micronutrients. A method is also disclosed that includes contacting a peppercorn with one or more oils thereby producing a de-flavored peppercorn.

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Номер записи: 94
23-05-2019 дата публикации

COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASE, CONTAINING OIL OF LITSEA JAPONICA AS ACTIVE INGREDIENT, AND METHOD FOR PREPARING SAME

Номер: US20190151391A1
Автор: BAIK Soon-Ok, CHO Ju-Hyun, CHOI Goo-Hee, JUNG Yong-Hwan, PARK In-Jae, PARK Sung-Hwan, SIN Seung-Hee, YOON Weon-Jong, YUN Ji-Hyun
Принадлежит:

The present invention relates to a composition for an inflammatory disease, using and more specifically to a composition for preventing and treating an inflammatory disease, containing the oil derived from the fruits or the seeds of and a method for preparing the same. The present invention uses the fruits (excluding the seeds) or the seeds of and obtains the oil, which is used as an active ingredient of a composition for preventing and treating an inflammatory disease, by using n-hexane, wherein the oil is obtained by: separating the fruits (excluding the seeds) of from the seeds; injecting n-hexane, which is a solvent, into the fruits (excluding the seeds) or the seeds, 9-11 times greater than the weight of each: stirring the same for 24 hours at room temperature and extracting the same; and removing a hexane layer. 1Litsea japonica. A method for preparing oil from for preventing and treating an inflammatory disease , comprising:{'i': 'Litsea japonica', 'inputting the fruits of 9˜11 times weight into n-hexane which is a solvent;'}agitating the material for 24 hours at room temperature, and the material is subjected to extraction; andobtaining oil after removing a hexane layer.2Litsea japonica. The method of claim 1 , wherein the fruits of are separated into fruits (excludeding seeds) and seeds claim 1 , and oil can be prepared with the separated fruits (excludeding seeds) and seeds. This application is a Division of application Ser. No.14/889,611, filed Nov. 6, 2015, which in turn claims the benefit of the U.S. National Phase under 35 U.S.C. § 371 of International Application No. PCT/KR2014/003883 filed on Apr. 30, 2014, and the benefit of Korean Application No. 10-2013-0050388, filed on May 6, 2013, the disclosures of which are incorporated by reference into the present application.The present invention relates to a composition for an inflammatory disease using a and in particular to a composition for preventing and treating an inflammatory disease, which ...

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Номер записи: 95
23-05-2019 дата публикации

DAPHNE LAUREOLA EXTRACTS IN THE TREATMENT OF DERMOPATHIES

Номер: US20190151395A1
Автор: Folino Gallo Gioacchino, Fresta Massimo, Paolino Donatella, Spataro Leone, Venditti Alessandro
Принадлежит:

The invention relates to an extract obtained from L to be used the pharmaceutical cosmetic and cosmeceutical field for the topical treatment of dermopathies in general and of psoriasis in particular, by means of the topical application of effective amounts of said extracts. The invention also relates to the pharmaceutical, cosmetic and cosmeceutical compositions comprising the extracts. The invention also relates to the topical treatment of dermopathies in general and of psoriasis in particular. 118-. (canceled)19: A method for treating a dermopathy or a skin disease characterized by cell hyperproliferation comprising topically administering to an individual in need thereof a pharmaceutical , cosmetic or cosmeceutical formulation comprising:{'i': 'Daphne laureola', '(a) a phytocomplex concentrate extracted from a plant or plant part, wherein the phytocomplex concentrate is present in the pharmaceutical, cosmetic or cosmeceutical formulation in an amount sufficient to treat the dermopathy or the skin disease characterized by cell hyperproliferation, and'}(b) a pharmaceutically, cosmetically or cosmeceutically acceptable component or a topical emollient,{'i': 'Daphne laureola', 'wherein the phytocomplex concentrate is prepared from the plant or plant part by a method comprising [{'i': Daphne laureola', 'Daphne laureola, '(i) preparing an infusion of the plant or plant part by a method comprising steeping the plant or plant part in previously boiled water or a polar solvent, thereby extracting the phytocomplex into the water or polar solvent;'}, {'i': Daphne laureola', 'Daphne laureola, '(ii) preparing a decoction of the plant or plant part by a method comprising steeping the plant or plant part in cold water, then bring the water to a boil, thereby extracting the phytocomplex into the water;'}, {'i': Daphne laureola', 'Daphne laureola, '(iii) steeping the plant or plant part in an alcoholic or hydroalcoholic solution, thereby extracting the phytocomplex into the ...

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Номер записи: 96
23-05-2019 дата публикации

PROCESS FOR FRACTIONATION AND EXTRACTION OF HERBAL PLANT MATERIAL TO ISOLATE EXTRACTIVES FOR PHARMACEUTICALS AND NUTRACEUTICALS

Номер: US20190151770A1
Автор: Brandenburg James Etson, Mitchell Melvin
Принадлежит:

A process for fractionating a plant material to provide isolated extractives, the process includes pretreating the plant material to provide a fluidized plant material, subjecting the pretreated fluidized plant material to high frequency pulses and shear forces without denaturing bioactive aspects of one or more components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, separating the first liquid fraction having extractives from the first fractionated plant material, and isolating extractives from the first liquid fraction. 1. A process for fractionating a plant material to provide isolated extractives , the process comprising:a) pretreating the plant material to provide a fluidized plant material;b) subjecting the pretreated fluidized plant material to simultaneous high frequency pulses and shear forces without denaturing bioactive properties of one or more bioactive components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, wherein the high frequency pulses are between about 300 pulses per second and about 2000 pulses per second;c) separating the first liquid fraction having extractives from the first fractionated plant material; andd) isolating extractives from the first liquid fraction.2. The process according claim 1 , wherein step d) of isolating comprises contacting the first liquid fraction having extractives with a membrane for selectively isolating the extractives based on molecular weight.3. The process according to claim 1 , wherein the step of pretreating comprises soaking in a solvent selected from the group consisting of water and ethanol.4. The process of claim 1 , wherein step c) of separating the first liquid having extractives from the first fractionated plant material comprises a compressive force applied to the first fractionated plant material.5. The process according to claim 1 ...

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Номер записи: 97
14-05-2020 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING REFINED INDIGO NATURALIS EXTRACTS AND THE USE THEREOF

Номер: US20200147163A1
Автор: Andres Philippe, CHANTALAT Laurent
Принадлежит:

A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition. 1. A method of inhibiting proliferation or differentiation of keratinocytes , inhibiting infiltration of mononuclear cells into the dermis and epidermis , inhibiting vascular alteration resulting in hyperplastic blood vessels , or inhibiting upregulation of adhesion molecules on endothelia cells , the method comprising administering to a subject in need thereof a pharmaceutical composition comprising an extract of Indigo Naturalis , wherein the extract comprises , relative to the total weight of the extract:65% to 90% (w/w) indirubin;0.1-15% (w/w) indigo; and0.01-5% (w/w) tryptanthrin.2. The method of claim 1 , wherein the method is for inhibiting proliferation or differentiation of keratinocytes.3. The method of claim 2 , wherein the pharmaceutical composition comprises 0.002% to 0.077% (w/w) of the extract relative to the total weight of the pharmaceutical composition.4. The method of claim 3 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.5. The method of claim 2 , wherein the extract further comprises 0.1-5% (w/w) tryptanthrin relative to the total weight of the extract.6. The method of claim 5 , wherein the extract further comprises 0.1-5% (w/w) qingdainone relative to the total weight of the extract.7. The method of claim 1 , wherein the method is for inhibiting infiltration of mononuclear cells.8. The method of claim 7 , wherein the pharmaceutical composition comprises 0.002% to 0.077% (w/w) of the extract relative to the total weight of the pharmaceutical composition.9. The method of claim 8 , wherein the pharmaceutical composition further comprises a ...

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Номер записи: 98
14-06-2018 дата публикации

Vaporized Medicants and Methods of Use

Номер: US20180161384A1
Автор: Bartkowski William P., Chong Alexander ChinHak, Thompson Marshall A.
Принадлежит:

A method and formulation for delivering an active analgesic compound, such as an opiate, in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the active compound. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer. 1. A method for delivering medicants through inhalation , comprising: i. an excipient comprising propylene glycol present at approximately 1 percent to approximately 30 percent of the excipient, vegetable glycerin present at approximately 1 percent to approximately 30 percent of the excipient, water present at approximately 0.01 percent to approximately 30 percent of the excipient, and alcohol present at approximately 0.01 percent to approximately 30 percent of the excipient, and', 'ii. fentanyl; and, 'a. acquiring a medicant solution suitable for vaporization, the medicant solution, comprisingb. vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the medicant solution is provided to a user for inhalation, wherein the step of vaporizing the medicant solution comprises using a vaporizer.2. A method for delivering medicants through inhalation , comprising: i. an excipient comprising an inert non-reactive compound, and', 'ii. an analgesic; and, 'a. acquiring a medicant solution suitable for vaporization, the medicant solution, comprisingb. vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. within 2 minutes of activation such that an effective serving of the analgesic is ...

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Номер записи: 99
29-09-2022 дата публикации

METHANOL-BASED EXTRACTION OF PSYCHOACTIVE ALKALOIDS FROM FUNGUS

Номер: US20220305402A1
Автор: LIGHTBURN Benjamin, MOSS Ryan, RANKEN Lisa
Принадлежит:

This invention relates to the extraction of psychoactive compounds from fungus for use in medicine. Raw fungus is dried and ground. The solvent used for extraction is methanol or a hydro-methanol mixture, an acidic hydro-methanol mixture, or an alkaline hydro-methanol mixture. The extraction slurry is filtered and pH-adjusted if necessary. The methanol in the solvent is then completely evaporated and water added back, where necessary, to form a concentrated slurry. The concentrated slurry is then standardized to provide a known concentration of the psychoactive alkaloids that have been extracted. The standardized slurry may then be dried to result in a powdered extract with a precisely defined purity of psychoactive compounds. 1. A process for forming an extract with a specified concentration of psychoactive alkaloids from a dried , raw , psychedelic fungus comprising the steps of:soaking a biomass of the dried, raw, psychedelic fungus in a solvent that is methanol, a water-methanol mixture or a buffered water-methanol mixture in order to dissolve the psychoactive alkaloids in the solvent;filtering an undissolved portion of the biomass from the solvent;evaporating the solvent sufficiently to remove the methanol completely, leaving a concentrated slurry or a residue that is converted to the concentrated slurry by adding water thereto;measuring a psychoactive alkaloid content in the concentrated slurry;measuring a dry mass content in the concentrated slurry;using the psychoactive alkaloid content, the dry mass content and the specified concentration to determine a quantity of a carrier to add to the concentrated slurry in order to obtain the specified concentration of the psychoactive alkaloids in the extract;standardizing the concentrated slurry by adding thereto the quantity of the carrier; anddrying the concentrated slurry to result in the extract with the specified concentration of the psychoactive alkaloids.2. The process of claim 1 , wherein the extract is a ...

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Номер записи: 100