16-05-2013 дата публикации
Номер: US20130123265A1
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity. 2. The compound of claim 1 , wherein:{'sup': '1', 'Ris hydrogen, methyl, ethyl, n-propyl or iso-propyl.'}3. The compound of or claim 1 , wherein:{'sup': 4', '8, 'sub': 2', '3', '3', '1', '6', '1', '6', '1', '6', '3', '8', '1', '6, 'Ris a phenyl, optionally substituted with at least one substituent selected from F, Cl, Br, I, —CN, —NO, —CF, —OH, —OR, —OCF, C-Calkyl, C-C-fluoroalkyl, C-Cheteroalkyl, C-Ccycloalkyl, and C-Chaloalkyl.'}54. The compound of any of claim 1 , claim 1 , or claim 1 , wherein:{'sup': 4', '8', '9', '9', '9', '9', '9', '8', '9', '9', '9', '8', '9', '8', '9', '9', '8', '8, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris substituted with at least one substituent selected from —NHS(═O)R, —S(═O)N(R), —N(R)S(═O)N(R), —N(R), —N(R)C(═O)R, —N(R)C(═O)N(R), —N(R)C(═O)OR, —COR, —C(═O)R, —OC(═O)N(R), —CON(R), —SR, or —S(═O)R.'}6. The compound of claim 1 , wherein:{'sup': '4', 'Ris selected from phenyl; 2-fluorophenyl; 3-fluorophenyl; 4-fluorophenyl; 2-chlorophenyl; 3-chlorophenyl; 4-chlorophenyl; 2,4-dichlorophenyl; 2,3-dichlorophenyl; 3,4-dichlorophenyl; 3,5-dichlorophenyl; 2-bromophenyl; 3-bromophenyl; 4-bromophenyl; 2-iodophenyl; 3-iodophenyl; 4-iodophenyl; 2-methylphenyl; 3-methylphenyl; 4-methylphenyl; 2,4-dimethylphenyl; 2,3-dimethylphenyl; 3,4-dimethylphenyl; 3,5-dimethylphenyl; 2-trifluoromethylphenyl; 3-trifluoromethylphenyl;'}{'b': '4', 'and -trifluoromethylphenyl.'}76. The compound of - claims 1 , wherein:{'sup': 2', '8, 'sub': 2', '3', '3', '1', '6', '1', '6', '1', '6', '3', '8', '1', '6, 'Ris a phenyl, optionally substituted with at least one ...
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