Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 80187. Отображено 100.
05-01-2012 дата публикации

Pharmaceutical compositions of dextran polymer derivatives

Номер: US20120003282A1
Автор: Corey J. Bloom, Daniel E. Dobry, Daniel T. Smithey, David K. Lyon, David T. Vodak, Dwayne T. Friesen, Michael M. Morgen, Warren K. Miller
Принадлежит: Bend Research Inc

Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.

Подробнее
Номер записи: 1
05-01-2012 дата публикации

Solid Dosage Forms Of Bendamustine

Номер: US20120003309A1
Автор: Jeffrey Colledge, Margaretha Olthoff, Taoufik Ouatas, Thomas Alfred Profitlich, Ulrich Patzak
Принадлежит: ASTELLAS DEUTSCHLAND GMBH

In the present invention there is provided a pharmaceutical composition in a solid dosage form suitable for oral administration, the composition comprising bendamustine or a pharmaceutically acceptable ester, salt or solvate thereof as an active ingredient, and at least one pharmaceutically acceptable excipient, which is a pharmaceutically acceptable saccharide selected from the group consisting of one or more of a monosaccharide, a disaccharide, an oligosaccharide, a cyclic oligosaccharide, a polysaccharide and a saccharide alcohol, wherein the ratio by weight of the active ingredient to the saccharide excipient(s) is in the range of 1:1-5.

Подробнее
Номер записи: 2
05-01-2012 дата публикации

Dpp iv inhibitor formulations

Номер: US20120003313A1
Автор: Anja Kohlrausch, Gerd Seiffert, Patrick Romer
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to pharmaceutical compositions of DPP IV inhibitors with an amino group, their preparation and their use to treat diabetes mellitus.

Подробнее
Номер записи: 3
12-01-2012 дата публикации

Solid composition containing bacillus-type non-pathogenic bacterial spores

Номер: US20120009167A1
Автор: Tiziano Prato
Принадлежит: Sanofi Aventis SpA

The invention relates to a composition of spores of nonpathogenic bacteria of the Bacillus genus, adsorbed onto a matrix made up of at least one water-insoluble adsorbent compound and a cellulose derivative, which can be obtained by the fluidized air bed technique, useful in the pharmaceutical, veterinary and nutrition fields.

Подробнее
Номер записи: 4
12-01-2012 дата публикации

Ophthalmic compositions based on polyunsaturated omega-3 and omega-6 fatty acids

Номер: US20120010280A1
Автор: Danilo Aleo, Maria Grazia Antonietta Saita, Maurizio Rolando, Sergio Mangiafico, Stefano Barabino
Принадлежит: TRB CHEMEDICA INTERNATIONAL SA

The invention concerns topical compositions for the prevention and treatment of ocular pathologies, in particular inflammatory keratites and conjunctivites and dry eye syndrome, containing as active ingredients polyunsaturated fatty acids of the types omega-3 and omega-6, and specifically EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and GLA (γ-linolenic acid), mixed with vitamin E acetate and formulated in a stable composition in hydrogel, i.e. in dispersed form in an aqueous vehicle containing one or more gelling polymers. The proposed compositions are particularly indicated for use as artificial tears.

Подробнее
Номер записи: 5
19-01-2012 дата публикации

Methods and compositions for cns delivery of heparan n-sulfatase

Номер: US20120014936A1
Автор: Brian Vernaglia, Farah Natoli, Gaozhong Zhu, Jamie Tsung, Jennifer Terew, Jing Pan, Pericles Calias, Richard Pfeifer, YUAN Jiang, Zahra Shahrokh
Принадлежит: Shire Human Genetics Therapies Inc

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.

Подробнее
Номер записи: 6
19-01-2012 дата публикации

Modified release formulations containing drug-ion exchange resin complexes

Номер: US20120015030A1
Автор: Ketan Mehta, Yu-Hsing Tu
Принадлежит: Tris Pharma Inc

A solid dose composition containing a mixture of a cured, modified release-barrier coated methylphenidate-ion exchange resin complex-matrix and an uncoated methylphenidate-ion exchange resin complex is described. The barrier coated methylphenidate-ion exchange resin complex-matrix comprises methylphenidate complexed with a pharmaceutically acceptable ion-exchange resin to form the complex which is admixed with a polymer to form a methylphenidate-ion exchange resin complex-matrix, which is subsequently coated with a modified release coating. The modified coating contains polyvinyl acetate polymer and a plasticizer and is cured.

Подробнее
Номер записи: 7
19-01-2012 дата публикации

Pharmaceutical composition for external use

Номер: US20120015997A1
Автор: Akira Nozawa, Hirokazu Kobayashi, Hiroyuki Fujii, Toyohiko Miki
Принадлежит: Nihon Nohyaku Co Ltd, Pola Pharma Inc

Provided is a pharmaceutical composition for external use, including: (i) a compound represented by structural formula (2) and/or a salt thereof; and (ii) N-methyl-2-pyrrolidone.

Подробнее
Номер записи: 8
26-01-2012 дата публикации

Delayed release, oral dosage compositions that contain amorphous cddo-me

Номер: US20120022156A1
Автор: Colin J. Meyer, Jiang Zhang
Принадлежит: Reata Pharmaceuticals Inc

Pharmaceutical formulations exhibit a desirably low Cmax, among other properties, that contain particles of amorphous bardoxolone methyl, either in pure form or in the form of a solid dispersion, admixed with particles of a hydrophilic binding agent. Such formulations possess the advantage of higher oral bioavailability, relative to formulations based on the crystalline form of bardoxolone methyl.

Подробнее
Номер записи: 9
02-02-2012 дата публикации

Transdermal pharmaceutical preparations

Номер: US20120024743A1
Автор: Endre Mikulásik, Patrik Fazekas
Принадлежит: EGIS PHARMACEUTICALS PLC

The present invention relates to semisolid transdermal pharmaceutical preparation having enhanced stability and bioavailability, wherein the particles are coated by a volatile silicon oil component and the thus obtained suspension is dispersed in a gel or cream base.

Подробнее
Номер записи: 10
02-02-2012 дата публикации

Medicinal Cream Made Using Neomycin Sulphate, Betamethasone Valerate, And Chitosan, And A Process To Make The Same

Номер: US20120028942A1
Автор: Haridas Sankar, Kuppusamy Senthilkumar, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Vanangamudi Subramaniam Sulur
Принадлежит: Apex Labs Private Ltd

The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), neomycin sulphate & betamethasone valerate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, a corticosteroid Betamethasone Valerate, and an antibacterial agent Neomycin Sulphate, are incorporated in cream base for use in treating bacterial skin infections and skin inflammation due to allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition.

Подробнее
Номер записи: 11
02-02-2012 дата публикации

Clonidine for treatment of bone cancer

Номер: US20120029042A1
Автор: Vanja Margareta King
Принадлежит: WARSAW ORTHOPEDIC INC

The present invention is directed to a method for treating osteolytic bone cancer. The method comprises implanting a drug depot locally at or near the osteolytic bone cancer, wherein the drug depot comprises at least one biodegradable polymer and clonidine in an amount from about 0.1 wt. % to about 30 wt. % of the drug depot.

Подробнее
Номер записи: 12
02-02-2012 дата публикации

Posterior segment drug delivery

Номер: US20120029470A1
Автор: Cary J. Reich, Douglas Sutton, Eugene de Juan, Jr., Hanson S. Gifford, Iii, K. Angela Macfarlane, Kathleen Cogan Farinas, Michael Barrett, Randolph E. Campbell, Yair Alster
Принадлежит: ForSight Vision4 Inc

A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Подробнее
Номер записи: 13
09-02-2012 дата публикации

Ophthalmic compositions and methods for treating ophthalmic conditions

Номер: US20120035148A1
Автор: Scott M. Whitcup
Принадлежит: Allergan Inc

Compositions, and methods of using such compositions, useful for placement, for example injection, into the interior of human or animal eyes are provided. Such compositions include a therapeutic component, such as one or more corticosteroids, a biocompatible polymeric component, and a solvent component.

Подробнее
Номер записи: 14
09-02-2012 дата публикации

Compounds and medical devices activated with solvophobic linkers

Номер: US20120035321A1
Автор: Philippe Gravagna, Sébastien LADET
Принадлежит: Sofradim Production SAS

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Подробнее
Номер записи: 15
16-02-2012 дата публикации

Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Номер: US20120039980A1
Автор: David M. Gravett, George Y. Daniloff, Jacqueline Schroeder, Louis C. Sehl, Olof Mikael Trollsas, Philip M. Toleikis
Принадлежит: AngioDevice International GmbH

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.

Подробнее
Номер записи: 16
16-02-2012 дата публикации

Novel biomaterials, their preparation and use

Номер: US20120040901A1
Автор: Christian Schoch, György Lajos KIS, Jozsef Szejtli, Lajos Szente
Принадлежит: Individual

The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

Подробнее
Номер записи: 17
16-02-2012 дата публикации

2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity

Номер: US20120040989A1
Автор: Christian Hubschwerlen, Cornelia Zumbrunn Acklin, Georg Rueedi, Jean-Philippe Surivet
Принадлежит: ACTELION PHARMACEUTICALS LTD

The invention relates to antibacterial compounds of formula I wherein R 1 represents alkoxy; each of U and V represents CH and W represents CH or N, or U represents N, V represents CH and W represents N, or each of U and V represents N and W represents CH; R 2 represents hydrogen or fluorine when W represents CH or R 2 represents hydrogen when W represents N; A represents O or CH 2 ; Y represents CH or N; Q represents O or S; and n represents 0 or 1; and salts of such compounds.

Подробнее
Номер записи: 18
23-02-2012 дата публикации

Method of stabilizing and sterilizing peptides or proteins

Номер: US20120045431A1
Автор: John T. Trogden, Robert T. Lyons
Принадлежит: Allergan Inc

The present invention provides a method for sterilizing a protein-containing bioerodible implant. The sterilization is accomplished using β-radiation, or high energy electrons. Following sterilization the implant can be used in a variety of methods for the sustained release of a therapeutic protein to treat a disease or condition in a human or non-human subject. The sterilization process is compatible with proteins containing one or more disulfide bonds or easily oxidized methionine residues.

Подробнее
Номер записи: 19
23-02-2012 дата публикации

Thermosensitive hepatitis b vaccine

Номер: US20120045511A1
Автор: Ho-Yuan Chou, Hsin-Hsin Shen, Mi-Hua Tao, Tsai-Yu Lin
Принадлежит: Industrial Technology Research Institute ITRI

A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer; a surface antigen of hepatitis B virus (HBsAg); and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.

Подробнее
Номер записи: 20
08-03-2012 дата публикации

Polysaccharide pseudo-sponge

Номер: US20120055780A1
Автор: Tomoya Sato
Принадлежит: Seikagaku Corp

A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoreactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyeaffinity.

Подробнее
Номер записи: 21
08-03-2012 дата публикации

Modulation of drug release rate from electrospun fibers

Номер: US20120058100A1
Автор: Jay C. Sy, V. Prasad Shastri
Принадлежит: Individual

Disclosed are co-electrospun polymeric fibers comprising polymers comprising pharmaceutically active agents and/or biologically active agents and capable of release at a combined release rate. Also disclosed are processes for preparing polymeric fibers capable of release at a combined release rate. Also disclosed are processes of modulating delivery rate of pharmaceutically active agents and/or biologically active agents. Also disclosed are processes of delivering pharmaceutically active agents and/or biologically active agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Подробнее
Номер записи: 22
08-03-2012 дата публикации

Dispersions of rasagiline citrate

Номер: US20120059058A1
Автор: David Engers, Keith Lorimer
Принадлежит: Teva Pharmaceutical Industries LTD

The subject invention provides a solid dispersion of rasagiline citrate, a composition and a process for the manufacture thereof.

Подробнее
Номер записи: 23
08-03-2012 дата публикации

Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor

Номер: US20120059462A1
Автор: Vernon G. Wong
Принадлежит: Allergan Inc

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

Подробнее
Номер записи: 24
15-03-2012 дата публикации

Delivery system with scaffolds

Номер: US20120063997A1
Автор: Cheryl Hunter, Kevin Morris Shakessheff, Robin Andrew Quirk
Принадлежит: REGENTEC Ltd

An injectable, agent delivery system comprising a composition comprising: (i) an injectable scaffold material comprising discrete particles, which are capable of interacting to form a scaffold; and (ii) a carrier comprising an agent for delivery. The product can have a pharmaceutical use or use in cosmetic surgery; in particular it can be used in tissue regeneration or reconstruction. The agent for delivery may be a therapeutically, prophylactically or diagnostically active substance.

Подробнее
Номер записи: 25
15-03-2012 дата публикации

Delivery system for delivery of a substance into the oral cavity

Номер: US20120065160A1
Автор: Jonatan Moses
Принадлежит: NEOINVENT MEDICAL ENGR AB

A delivery system for use in the oral cavity, the system comprising a carrier for a bioactive substance. The carrier has a surface comprising oxygen-binding sites (X), and at least one link comprising a pentose group and one or more additional sugar groups, the pentose group being bonded to one of said oxygen binding sites (X) and wherein one or more bioactive molecules (R) are bonded directly to one of the sugar groups of the at least one link or to one or more substituents on one or more sugar groups in the at least one link.

Подробнее
Номер записи: 26
22-03-2012 дата публикации

Targeted multi-epitope dosage forms for induction of an immune response to antigens

Номер: US20120070493A1
Автор: Christopher Fraser, David H. Altreuter, Grayson B. Lipford
Принадлежит: Selecta Biosciences Inc

Provided herein are compositions and methods related to MHC II binding peptides. In some embodiments, the peptides are obtained or derived from a common source. In other embodiment, the peptides are obtained or derived from an infectious agent to which a subject has been repeatedly exposed.

Подробнее
Номер записи: 27
05-04-2012 дата публикации

Novel albumin-free factor viii formulations

Номер: US20120083446A1
Автор: Erik Bjornson, Feroz Jameel, John Carpenter, Marc Besman, Michael Pikal, Ramesh Kashi, Serguei Tchessalov
Принадлежит: Baxter International Inc, University of Connecticut

An albumin-free Factor VIII formulation comprising, 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent.

Подробнее
Номер записи: 28
12-04-2012 дата публикации

Use of inhibitors of bruton's tyrosine kinase (btk)

Номер: US20120087915A1
Автор: David J. Loury, Eric Hedrick, Gwen Fyfe, Joseph J. Buggy, Laurence Elias, Tarak D. Mody
Принадлежит: Pharmacyclics LLC

Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

Подробнее
Номер записи: 29
12-04-2012 дата публикации

Extended release opioid abuse deterrent compositions and methods of making same

Номер: US20120087982A1
Автор: David Dixon, Dilip B. Wadgaonkar, Divya Tewari, Vijai Kumar
Принадлежит: Acura Pharmaceuticals Inc

This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.

Подробнее
Номер записи: 30
12-04-2012 дата публикации

Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical fromulations

Номер: US20120088726A1
Автор: Annalisa Sforzini, Carla Caramella, Giuseppe Bottoni, Giuseppe Claudio Viscomi, Mascia Federici, Paola Maffei, Silvia Rossi
Принадлежит: Alfa Wasserman SpA

Object of the invention are mucoadhesive and controlled release formulations consisting of aqueous solutions containing 0.05% to 5% by weight of a natural purified polymer having xyloglucan structure and 10% to 70% by weight of glycerol. These formulations are suitable for the application on human mucous membranes, such as nasal, oral and vaginal mucous membranes, as moisturizing and softening agents or as pharmaceutical release system. Further objects of the invention are pharmaceutical formulations and medical devices suitable for the application to human mucous membranes, containing the mucoadhesive and controlled release formulations together with active ingredients and excipients.

Подробнее
Номер записи: 31
19-04-2012 дата публикации

Adhesive patch-containing package bag and method for storing adhesive patch

Номер: US20120090275A1
Автор: Naoyuki Uchida, Yasunori Takada, Yuka Takagi
Принадлежит: Hisamitsu Pharmaceutical Co Inc

The present invention relates to an adhesive patch-containing package bag 1, having: a package bag 8; and an adhesive patch 10 stored inside the package bag 8, wherein the adhesive patch 10 has a backing 12, an adhesive layer 14 laminated on at least one side of the backing 12 and containing ropinirole and/or a pharmaceutically acceptable salt thereof, and a release liner 16 covering the adhesive layer 14, and a relative humidity at 4° C. is maintained at 35% or higher inside the package bag 8.

Подробнее
Номер записи: 32
19-04-2012 дата публикации

Sustained-release formulation for injection

Номер: US20120091022A1
Автор: Norimasa Koseki, Takashi Nakagawa
Принадлежит: Sumitomo Dainippon Pharma Co Ltd

The present invention relates to a composition comprising N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2R,3R)-2,3-tetramethylene-butyl]-(1′R,2′S,3′R,4′S)-2,3-bicyclo[2,2,1]heptanedicarboximide or a pharmaceutically acceptable acid addition salt thereof. In detail, the composition relates to a sustained release formulation for injection which maintains an effective blood level of the above-mentioned compound.

Подробнее
Номер записи: 33
19-04-2012 дата публикации

Bioavailability Enhancement Delivery System

Номер: US20120095098A1
Автор: Bhiku Patel
Принадлежит: PruGen IP Holdings Inc

A composition for increasing the bioavailability of drugs in humans and animals comprising a microemulsion further comprising a first emulsifier, a second emulsifier, and an oil wherein the emulsifiers have individual HLB values of between about 10 and about 30, are in a ratio ranging from about 1:1 to about 4:1; and, the first and second emulsifier combination and oil are in a ratio of about 99:1 to about 9:1. A method for increasing the bioavailability of such a composition is also provided.

Подробнее
Номер записи: 34
26-04-2012 дата публикации

Pharmaceutical formulations of a substituted diaminopurine

Номер: US20120100213A1
Автор: Anthony Joseph FRANK, Anthony Tutino, Sreenivas S. Bhat, Xiaozhong Liang
Принадлежит: Signal Pharmaceuticals LLC

Provided herein are pharmaceutical formulations, comprising 4-((9-((3S)-tetrahydro-3-furanyl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)-trans-cyclohexanol, including pharmaceutically acceptable salts, solvates, isomers, isotopologues, tautomers and racemic mixtures thereof, and a pharmaceutically acceptable excipient; and their use for treating or preventing disease.

Подробнее
Номер записи: 35
26-04-2012 дата публикации

Locally targeted anti-fibrotic agents and methods of use

Номер: US20120101325A1
Автор: Elaine Lee, John Scott Surfus
Принадлежит: Kyphon SARL

Effective devices and methods using an antifibrotic agent are provided for treating fibrosis or treating normal fibrous tissue. The devices and methods comprise an antifibrotic agent to degrade shrink, relax or stretch at least a portion of the fibrotic tissue. In some embodiments, the methods and devices are configured to immediately release an effective amount of the antifibrotic agent within 24 hours. In some embodiments, when the device comes in contact directly or indirectly with an activator, the antifibrotic agent will be immediately released from the depot. In some embodiments, the depot provides sustained release of the antifibrotic agent over a period of up to one year to treat fibrous tissue.

Подробнее
Номер записи: 36
03-05-2012 дата публикации

Films and particles

Номер: US20120107365A1
Автор: Aaron Griset, Jesse Wolinsky, Mark Grinstaff, Solomon Azouz, Yolonda Colson
Принадлежит: Boston University, Brigham and Womens Hospital Inc

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

Подробнее
Номер записи: 37
03-05-2012 дата публикации

Polymers and Hydrogels

Номер: US20120107369A1
Автор: Adrian S. Fox, Guoming Sun, Roy R. Yeoman, III
Принадлежит: nanoDERM LLC

Methods and compositions related polymers and hydrogels. In some cases to biodegradable hydrogels for use in medical applications are disclosed. The polymers and hydrogels may be produced from cross-linked dextran and poly(epoxides). The poly(epoxides) may be poloxamers.

Подробнее
Номер записи: 38
03-05-2012 дата публикации

Immuno-compatible hydrogel system

Номер: US20120107394A1
Автор: Casey Mills, Harald Stover, Nicholas Burke
Принадлежит: Individual

An immuno-compatible hydrogel system is provided that is resistant to protein binding. The hydrogel system is prepared by contacting a hydrogel solution with a cross-linking agent to form a gel, exposing the gel to an aqueous solution comprising a first polyelectrolyte to form a polyelectrolyte-coated hydrogel, exposing the polyelectrolyte-coated hydrogel to a second polyelectrolyte to form a crosslinked matrix and exposing the matrix to conditions which eliminates, or at least reduces, protein binding sites on the matrix.

Подробнее
Номер записи: 39
03-05-2012 дата публикации

Pharmaceutical formulation containing gelling agent

Номер: US20120108622A1
Автор: Benjamin Oshlack, Christopher Breder, Curtis Wright
Принадлежит: Purdue Pharma LP

Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.

Подробнее
Номер записи: 40
10-05-2012 дата публикации

Pharmaceutical composition for treating hcv infections

Номер: US20120114751A1
Автор: Andreas Leiminer, Dave Alan Miller, Emmanuel Scheubel, Kai Lindenstruth, Navnit Hargovindas Shah
Принадлежит: Hoffmann La Roche Inc

The present invention relates to a granular pharmaceutical composition comprising an HCV protease inhibitor and at least one poloxamer.

Подробнее
Номер записи: 41
10-05-2012 дата публикации

Peptide/particle delivery systems

Номер: US20120114759A1
Автор: Aleksander S. Popel, Joel Chaim Sunshine, Jordan Jamieson Green, Kristen Lynn Kozielski, Ron B. Shmueli, Stephany Yi Tzeng
Принадлежит: JOHNS HOPKINS UNIVERSITY

Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.

Подробнее
Номер записи: 42
10-05-2012 дата публикации

Combination/association of adapalene and benzoyl peroxide for treating acne lesions

Номер: US20120115947A1
Автор: Christian Loesche, Denis Gross, Marie-Line Abou Chacra Vernet, Michel Poncet
Принадлежит: Galderma Research and Development SNC

Acne lesions, whether of inflammatory and/or non-inflammatory type, are simultaneously or sequentially treated and their number reduced, via daily topical regimen, with the combination or association of adapalene or pharmaceutically acceptable salt thereof and benzoyl peroxide (BPO).

Подробнее
Номер записи: 43
10-05-2012 дата публикации

Modular ingestible drug delivery capsule

Номер: US20120116358A1
Автор: Anke Pierik, Frits Tobi DE JONGH, Hans Zou, Jeff Shimizu, Johan Frederik Dijksman, Lucian Remus Albu, Olaf Weiner
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

An ingestible capsule ( 10 ) is provided for delivery of a drug, the capsule ( 10 ) comprises a first module ( 11 ) and a second module ( 12 ). The first module ( 11 ) has at least one drug compartment ( 13 ) for comprising an amount of the drug. The drug compartment ( 13 ) is sealed by a foil ( 14 ) with an embedded conducting heating wire ( 15 ). The second ( 12 ) module comprises electronics ( 18 ) for providing an electrical pulse to the heating wire ( 15 ) in order to open the drug compartment ( 13 ) by melting the foil ( 14 ). The first module ( 11 ) and second module ( 12 ) comprise interoperable connection means ( 19 ) for securing the first module ( 11 ) to the second module ( 12 ) such that the heating wire ( 15 ) is electronically coupled to the electronics ( 18 ).

Подробнее
Номер записи: 44
17-05-2012 дата публикации

Compositions and methods for the prevention and treatment of cancer

Номер: US20120121649A1
Автор: Pedro Santamaria
Принадлежит: UTI LP

Conventional cancer immunotherapy falls short at efficiently expanding T cells that specifically target cancerous cells in numbers sufficient to significantly reduce the tumor size or cancerous cell number in vivo. To overcome this limitation, provided herein are nanoparticles coated with MHC class I and/or class II molecules presenting tumor-specific antigens and co-stimulatory molecules and their use to expand antigen-specific anti-tumorigenic T cells to levels not achieved in current immunotherapeutic techniques. These antigen-specific anti-tumorigenic T cells include cytotoxic T cells, effector T cells, memory T cells, and helper T cells that are necessary to initiate and maintain a substantial immune response against metastatic or non-metastatic cancerous, pre-cancerous, or neoplastic cells in vivo. The present invention describes a systemic approach to targeting cancerous or pre-cancerous cells that are circulating cells, as in lymphomas, migratory metastatic cells, and solid tumors.

Подробнее
Номер записи: 45
24-05-2012 дата публикации

Biocompatible carrier and method for fabricating the same

Номер: US20120128731A1
Автор: Shu-Chen Hsieh
Принадлежит: National Sun Yat Sen University

The invention provides a biocompatible carrier and method for fabricating the same. The biocompatible carrier includes: a gel, and a plurality of metal nanoparticles, an organic compound or combinations thereof embedded in the gel, wherein the metal nanoparticles, the organic compound or combinations thereof are uniformly distributed in the gel.

Подробнее
Номер записи: 46
24-05-2012 дата публикации

Modified hyaluronic acid polymer compositions and related methods

Номер: US20120128741A1
Автор: David M. Gravett, George Y. Daniloff, Pingren He
Принадлежит: Carbylan Biosurgery Inc

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

Подробнее
Номер записи: 47
31-05-2012 дата публикации

Method of Producing Protein-Carbohydrate Vaccines Reduced in Free Carbohydrate

Номер: US20120135030A1
Автор: Andrew Lees
Принадлежит: Fina BioSolutions LLC

This invention is directed to processes for reducing the level of free carbohydrate from a solution of protein-linked carbohydrate (conjugate) and non-linked carbohydrate. In this process, the conjugate is adsorbed to a hydrophobic membrane while the carbohydrate is not. The conjugate is then desorbed from the membrane, yielding a solution that is substantially reduced in free carbohydrate.

Подробнее
Номер записи: 48
31-05-2012 дата публикации

Oral Drug Delivery System

Номер: US20120135072A1
Автор: Arthur J. Tipton, Grant Schoenhard, John C. Middleton, John W. Gibson, Su Il Yum
Принадлежит: Durect Corp

Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

Подробнее
Номер записи: 49
07-06-2012 дата публикации

Aptamer bioconjugate drug delivery device

Номер: US20120141551A1
Автор: Aareet Krsna GANESH SHERMON, Abdel Rahman ELSAYED, Ian J. Mclennan, Juewen Liu, Nathan Jones, Ryan WAGNER, Steven Bloembergen
Принадлежит: Ecosynthetix Ltd

A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

Подробнее
Номер записи: 50
07-06-2012 дата публикации

Polymer Formulations for Delivery of Bioactive Materials

Номер: US20120142581A1
Автор: Adam Bell, David Taft, QIANG Zheng, Sandra Ottensmann, Stelios Tzannis, Steven Bitler, Wei-Guo Dai
Принадлежит: Landec Corp

PLGA, PLA and PGA polymers which have crystallinity resulting from the presence of long chain alkyl groups in terminal units. The polymers are particularly useful for drug delivery.

Подробнее
Номер записи: 51
28-06-2012 дата публикации

Aqueous composition for enteric hard capsule, method of preparing enteric hard capsule, and enteric hard capsule prepared using the method

Номер: US20120161364A1
Автор: Eun Hee Park, Hyon Ho Baek, Jae Uk Cha, Jin Ryul Son, Min Gyu Song, Sung Wan Lee
Принадлежит: Samsung Fine Chemicals Co Ltd

An aqueous composition for an enteric hard capsule, a method of preparing an enteric hard capsule, and an enteric hard capsule prepared using the method. The aqueous composition for an enteric hard capsule includes an enteric base material, a capsule forming aid, and a neutralizing agent. The method of preparing an enteric hard capsule includes: preparing an aqueous composition by dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water; preheating the aqueous composition to a temperature that is less than the gelation temperature for the aqueous composition; immersing a mold pin heated to a temperature that is greater than the gelation temperature for the aqueous composition into the aqueous composition; taking the mold pin out of the aqueous composition to obtain a film formed on the mold pin; and maintaining the film at a temperature that is equal to or greater than the gelation temperature for the aqueous composition for a predetermined period of time to fix the film on the mold pin and drying the film.

Подробнее
Номер записи: 52
28-06-2012 дата публикации

Transdermal drug delivery device including an occlusive backing

Номер: US20120165762A1
Автор: David Kanios, Juan A. Mantelle, Viet Nguyen
Принадлежит: Noven Pharmaceuticals Inc

A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.

Подробнее
Номер записи: 53
05-07-2012 дата публикации

Percutaneous absorption type plaster

Номер: US20120171278A1
Автор: Koji Tanaka, Yasuhiro Ikeura, Yasunori Takada
Принадлежит: Hisamitsu Pharmaceutical Co Inc

A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2 , wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is 1/3 times by mass to 4 times by mass as that of the rosin-based resin.

Подробнее
Номер записи: 54
05-07-2012 дата публикации

Novel Formulations of Volatile Anesthetics and Methods of Use for Reducing Inflammation

Номер: US20120171281A1
Автор: Danguole Spakevicius, Hatice Ozsoy
Принадлежит: University of Texas System

The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.

Подробнее
Номер записи: 55
12-07-2012 дата публикации

Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin

Номер: US20120177698A1
Автор: Gregor Cevc, Ulrich Vierl
Принадлежит: Individual

The invention describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug; the third component alternatively, can take the role of a drug. The disclosure further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The disclosure also provides methods and favourable conditions for carrier manufacturing and application.

Подробнее
Номер записи: 56
12-07-2012 дата публикации

Use of a copolymer in the form of a solubiliser for a poorly water-soluble compound

Номер: US20120178728A1
Автор: Kathrin Meyer-Böhm, Marianna Pierobon, Nathalie Bouillo, Rainer Dobrawa, Ralf Widmaier, Ronald Frans Maria Lange
Принадлежит: BASF SE

The use of copolymers obtained by free-radical polymerization of a mixture of i) 30 to 80% by weight of N-vinyllactam, ii) 10 to 50% by weight of vinyl acetate, and iii) 10 to 50% by weight of a polyether, with the proviso that the total of components i), ii) and iii) equals 100% by weight, as solubilizers for slightly water-soluble substances.

Подробнее
Номер записи: 57
12-07-2012 дата публикации

Co-Processed Excipient Compositions

Номер: US20120178822A1
Автор: Jagdish Balasubramaniam, Rama Krishna Haldar, Vinay Umesh Rao
Принадлежит: ISP Investments LLC

An oral solid dosage form having improved dissolution profile and a method of producing the same are provided. The present invention particularly provides a co-processed excipient composition and a method of producing the same. More particularly, it relates to a co-processed binary mixture of crosslinked polyvinylpyrrolidone and calcium silicate; wherein the weight ratio of crosslinked polyvinylpyrrolidone and calcium silicate is in the range of 1:1 to 20:1. The binary mixture when combined with a poorly soluble drug enhances its dissolution and extent of release.

Подробнее
Номер записи: 58
19-07-2012 дата публикации

use of inhibitors of bruton's tyrosine kinase (btk)

Номер: US20120183535A1
Автор: David J. Loury, Eric Hedrick, Gwen Fyfe, Joseph J. Buggy, Laurence Elias, Tarak D. Mody
Принадлежит: Pharmacyclics LLC

Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

Подробнее
Номер записи: 59
19-07-2012 дата публикации

Polyethylene glycol-based dendrons

Номер: US20120183578A1
Автор: Jieming Gao, Matthew S. Palombo, Patrick J. Sinko, Stanley Stein, Xiaoping Zhang, Yashveer Singh
Принадлежит: Rutgers State University of New Jersey

The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.

Подробнее
Номер записи: 60
19-07-2012 дата публикации

Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases

Номер: US20120183593A1
Автор: Clyde Schultz
Принадлежит: DirectContact LLC

This invention provides a polymeric drug delivery system including a hydrogel containing one or more drugs for the treatment of a posterior segment disease. Allowing passive transference of this drug from a dilute solution into the hydrogel produces the delivery system. The hydrogel, when placed in contact with the eye, delivers the drug. The delivery of the drug is sustained over an extended period of time, which is of particular utility in the eye, which is periodically flushed with tears. This sustained delivery accelerates the treatment process while avoiding potential damaging effects of localized delivery of high concentrations of compounds, e.g., from eye drops.

Подробнее
Номер записи: 61
19-07-2012 дата публикации

glucocorticoid therapy

Номер: US20120183610A1
Автор: Gudmundur Johannsson, Hans Lennernäs, Jörgen JOHNSSON, Stanko Skrtic, Thomas Hedner
Принадлежит: DuoCort Pharma AB

The present invention relates to improved glucocorticoid therapy and to treatment or prevention of a number of disorders that are due to a diminished or disrupted endogenous glucocorticoid secretory pattern. The invention is based on the findings that producing a specific serum Cortisol time profile that mimics the circadian rhythm of Cortisol of a healthy subject in a subject suffering from a diminished or disrupted glucocorticoid secretory pattern gives benefits with respect to reduction of side-effects.

Подробнее
Номер записи: 62
26-07-2012 дата публикации

Topical Delivery with a Carrier Fluid

Номер: US20120189557A1
Автор: Jane C. Hirsh, Mark Hirsh, Mark W. Trumbore, Ronald M. Gurge
Принадлежит: Precision Dermatology Inc

Aerosol spray formulations capable of delivering high concentrations of active agent-containing materials and/or excipient are described herein. The formulation contains a carrier fluid, a propellant and a therapeutic, prophylactic, cosmeticeutical and/or inert solid suspended, dissolved, or dispersed in the formulation. The active ingredient may be an antibiotic, an antihistamine, an anesthetic, an anti-inflammatory, and/or an astringent. In one embodiment, the active agent is an antifungal agent. In another embodiment, the active agent is a cosmeticeutical. The active agent can optionally be dispersed on, or associated with, a carrier powder. The carrier fluid is a highly volatile silicone liquid, which evaporates in less than 10 minutes after application of the formulation to the patient's skin. The formulation may also contain one or more pharmaceutically acceptable excipients The formulation can be packaged in a conventional aerosol spray can.

Подробнее
Номер записи: 63
26-07-2012 дата публикации

Novel injectable chitosan mixtures forming hydrogels

Номер: US20120189704A1
Автор: Abraham Patchornik, Dror Robinson, Noah Ben-Shalom, Zvi Nevo
Принадлежит: Chi2Gel Ltd

A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.

Подробнее
Номер записи: 64
26-07-2012 дата публикации

Androgen composition for treating an opthalmic condition

Номер: US20120190661A1
Автор: Adnan K.. Salameh, Anuradha V. Gore, Chetan P. Pujara, Jaya Giyanani, John T. Trogden
Принадлежит: Allergan Inc

The disclosure provides compositions for treating an ocular condition. The composition comprises a physiologically effective amount of an androgen, wherein the composition is suitable for topical administration to an eye. The disclosure further provides methods for treating an ocular condition with the disclosed compositions.

Подробнее
Номер записи: 65
26-07-2012 дата публикации

Controlled-Release CNS Modulating Compositions and Methods for the Treatment of Otic Disorders

Номер: US20120190671A1
Автор: Andrew M. Trammel, Benedikt Vollrath, Carl Lebel, Fabrice Piu, Jay Lichter, Jeffrey P. Harris, Luis A. Dellamary, Michael Christopher Scaife, Qiang Ye, Sergio G. DURÓN
Принадлежит: Otonomy Inc, UNIVERSITY OF CALIFORNIA

Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

Подробнее
Номер записи: 66
26-07-2012 дата публикации

Ketorolac tromethamine compositions for treating or preventing ocular pain

Номер: US20120190722A1
Автор: Christopher A. Muller, Janet K. Cheetham, Teresa H. Kuan
Принадлежит: Allergan Inc

Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein.

Подробнее
Номер записи: 67
02-08-2012 дата публикации

Ketorolac tromethamine compositions for treating or preventing ocular pain

Номер: US20120196913A1
Автор: Chin-Ming Chang, Devin F. Welty, Eldon Q. Farnes, Mayssa Attar, Rhett M. Schiffman, Richard S. Graham
Принадлежит: Allergan Inc

The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.

Подробнее
Номер записи: 68
09-08-2012 дата публикации

Pharmaceutical Compositions

Номер: US20120201888A1
Автор: Bernard Schachtel, John Ameling, Paul Bosse, Ray Takigiku
Принадлежит: Charleston Laboratories Inc

Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.

Подробнее
Номер записи: 69
09-08-2012 дата публикации

Transdermal delivery patch

Номер: US20120201891A1
Автор: Giacinto Gaetano, Jeremy Cottrell, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
Принадлежит: Phosphagenics Ltd

A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.

Подробнее
Номер записи: 70
16-08-2012 дата публикации

Methods of treating macular edema using antiedema therapeutics

Номер: US20120207682A1
Автор: Paul Ashton
Принадлежит: PSIVIDA US Inc

The invention provides methods of treating macular edema in a patient that include determining whether the patient has been diagnosed with or has experienced symptoms of macular edema for a predetermined period of time. If the patient has been diagnosed with or has experienced symptoms of macular edema for a predetermined period of time, the method of treatment includes administering a therapeutically effective amount of an AED to the patient. If the patient has not been diagnosed with or has experienced symptoms of macular edema for a predetermined period of time, the method of treatment optionally includes treating the patient with a therapy other than an AED. The invention further provides methods of treating macular edema in a patient using methods of and devices for administering an AED.

Подробнее
Номер записи: 71
16-08-2012 дата публикации

Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles

Номер: US20120208754A1
Автор: Anna Muchnik, Houdin Dehnad, Pamela J. Fereira, Stephen A. Berry
Принадлежит: Intarcia Therapeutics Inc

This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10 −7 reciprocal second.

Подробнее
Номер записи: 72
16-08-2012 дата публикации

(z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability

Номер: US20120208880A1
Автор: Gerrit Hauck
Принадлежит: SANOFI SA

The invention relates to solid pharmaceutical compositions comprising (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4′-trifluoromethylphenyl)-amide, as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from autoimmune diseases in particular systemic lupus erythematosus or chronic graft-versus-host disease, multiple sclerosis or rheumatoid arthritis.

Подробнее
Номер записи: 73
16-08-2012 дата публикации

Pad for herbal medicine in which release of medicinal ingredient can be controlled, and manufacturing method thereof

Номер: US20120209056A1
Автор: Hi Gu Kim
Принадлежит: BM BIOTECHNOLOGY LAB CO Ltd

The present disclosure relates to a method for manufacturing a pad for herbal medicine in which the release of medicinal ingredients can be controlled, which comprises: separating two or more medicinal herbal ingredients prescribed or prepared according to pharmacological effects on the basis of the weight ratio of each medicinal ingredient to total weight of the medicinal ingredients; grinding the medicinal ingredients separated on the basis of weight ratio, wherein fine particles are ground to different sizes according to the setting of release duration; preparing herbal medicine by mixing the ground medicinal ingredients together, and then mixing the ingredients with a binding agent; and adhering the herbal medicine to a base sheet. The pad for herbal medicine manufactured according to the method allows for persistent permeation of medical ingredients through the skin with different release rate for each medicinal ingredient, and thus, the efficacy of the medicinal ingredient layer and the effect of treating disease can be maximized.

Подробнее
Номер записи: 74
23-08-2012 дата публикации

Composition for promoting wound healing

Номер: US20120213843A1
Автор: Anders Carlsson, Jan Holmback
Принадлежит: LIPIDOR AB

A lipid layer forming wound healing promoting composition comprising volatile silicone oil, polar lipid, C 2 -C 4 aliphatic alcohol, and a wound healing agent, in particular a low to medium size natural or synthetic peptide. Also disclosed is a method of forming the lipid layer on a wound and a medical patch provided with the composition.

Подробнее
Номер записи: 75
23-08-2012 дата публикации

Topical formulations comprising a steroid

Номер: US20120214776A1
Автор: Ajay Sunil Vairale, Jeffrey A. Wayne, MISTRY Meghal, Refika Isil Pakunlu, Sateesh Kandavilli, Udhumansha Ubaidulla, Vijendra Nalamothu
Принадлежит: Dr Reddys Laboratories Inc, Dr Reddys Laboratories Ltd

The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.

Подробнее
Номер записи: 76
30-08-2012 дата публикации

Composition for inhalation

Номер: US20120216802A1
Автор: Maria Marlow, Nayna Govind
Принадлежит: AstraZeneca AB

The invention relates to a formulation comprising formoterol and budesonide for use in the treatment of respiratory diseases. The composition further contains HFA 227, PVP and PEG, preferably PVP K25 and PEG 1000.

Подробнее
Номер записи: 77
30-08-2012 дата публикации

Ophthalmic Solutions

Номер: US20120220961A1
Автор: Fu-Pao Tsao
Принадлежит: Individual

An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.001% and about 0.01% by weight stabilized hydrogen peroxide in said formulation as a preservative, one or more ocularly-compatible hydrogen peroxide stabilizers, hydroxypropylmethylcellulose and sodium carboxymethylcellulose, as well as pharmaceutical compositions comprising such solutions, are provided.

Подробнее
Номер записи: 78
06-09-2012 дата публикации

Bepotastine compositions

Номер: US20120225905A1
Автор: Angel Padilla, George Baklayan
Принадлежит: ISTA Pharmaceuticals Inc, Mitsubishi Tanabe Pharma Corp

Novel compositions including bepotastine besilate are provided such as sorbitol-free compositions, compositions including at least about 0.008% w/v benzalkonium chloride, and compositions including hydroxypropylmethyl cellulose E15 LV.

Подробнее
Номер записи: 79
13-09-2012 дата публикации

Tissue transplant compositions and methods for use

Номер: US20120230966A1
Автор: John M. Garvey, Keith D. Crawford, Pamela Layton
Принадлежит: Brigham and Womens Hospital Inc, PARCELL LABS LLC

Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult stem cells (ELA cells). Also provided is a method for augmenting formation of tissues and organs by administering a transplant having ELA stem cells or combination of ELA stem cells.

Подробнее
Номер записи: 80
13-09-2012 дата публикации

Block Copolymer For Intraperitoneal Administration Containing Anti-Cancer Agent, Micelle Preparation Thereof, And Cancer Therapeutic Agent Comprising The Micelle Preparation As Active Ingredient

Номер: US20120231053A1
Автор: Hiroko Mashiba, Yuichi Akatsu
Принадлежит: Nippon Kayaku Co Ltd

To provide a therapeutic method using a water soluble, high molecular weight block polymer to enable that an intraperitoneally administered anti-cancer agent may maintain for a long-term retention in the abdominal cavity to enoughly exert the effect of the anti-cancer agent and reduce adverse side-effects thereof. A therapeutic agent as a micelle preparation, comprising a copolymer having a hydrophilic polymeric moiety and a polycarboxylic acid derivative moiety; and an anti-cancer agent bonding to or encapsulated in the copolymer, wherein the micelle preparation may exhibit sustained drug release capability, and enables an extension of a retention time period of the anti-cancer agent in an abdominal cavity, is provided. A superior life-prolonging effect was found in an intraperitoneal administration mouse model compared with a case in which only an encapsulated drug is administered, and thus the present invention was completed accordingly.

Подробнее
Номер записи: 81
13-09-2012 дата публикации

Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders

Номер: US20120231062A1
Автор: Janusz Czernielewski, Michael Graeber
Принадлежит: Galderma Research and Development SNC

Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.

Подробнее
Номер записи: 82
13-09-2012 дата публикации

Vesicle compositions

Номер: US20120231067A1
Автор: Ananth Annapragada, Eric Tanifum, Indrani DASGUPTA, Mayank Srivastava, Mostafa Analoui
Принадлежит: Sensulin LLC, University of Texas System

Vesicle compositions are provided that comprise a therapeutic compound. The vesicle compositions may be capable of releasing the therapeutic compound in response to the presence of an external trigger. The vesicle compositions may comprise a plurality of biocompatible vesicles. The biocompatible vesicles may comprise a therapeutic compound for treatment of a patient in need thereof, and one or more cross-linkages between two or more of the biocompatible vesicles, each cross-linkage comprising a chemical sensing moiety and a sensed moiety. In some embodiments, the therapeutic compound may be any compound that provides palliative, curative, or otherwise beneficial effects to a patent.

Подробнее
Номер записи: 83
20-09-2012 дата публикации

Pegylated polyplexes containing two or more different polymers for polynucleotide delivery

Номер: US20120237565A1
Автор: Janni Mirosevich, Kevin Sill
Принадлежит: Intezyne Technologies Inc

The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.

Подробнее
Номер записи: 84
27-09-2012 дата публикации

Orally dispersible tablet

Номер: US20120244223A1
Автор: Naoki Nagahara, Tetsuya Matsuura, Yutaka Tanoue, Yutaka Yamagata
Принадлежит: Takeda Pharmaceutical Co Ltd

The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.

Подробнее
Номер записи: 85
04-10-2012 дата публикации

Biopolymer hybrid gel-depot delivery system

Номер: US20120251536A1
Автор: Brendon Yew Loong Chua, David Charles Jackson, David Edward Mainwaring, Mohammad Al Kobaisi, Weiguang Zeng
Принадлежит: POLYMERS CRC LTD

The invention relates to biopolymer-gel based depot systems for prolonged and/or controlled release delivery of biologically active agents, methods for the manufacture of the biopolymer based gel-depots which include a biologically active agent, and uses of such biopolymer gel-depots in therapy. The biopolymer-gel based depot systems comprise a biocompatible polyaminosaccharide and/or protein; a biocompatible phosphate and/or sulphonamide compound; a biologically active agent; an aqueous insoluble alkaline earth metal phosphate; and a biocompatible glycan and/or proteoglycan.

Подробнее
Номер записи: 86
04-10-2012 дата публикации

Method for treating vitiligo with a prostaglandin analogue

Номер: US20120251613A1
Автор: Rajeev Jain, Satya Srinivas Chetlapalli, Tarun Narang
Принадлежит: Agila Specialities Pvt Ltd

A method of stimulating melanogenesis in a skin surface of a patient, by treating the skin surface with a topical formulation comprising an effective amount of 17-phenyl-18,19,20-trinor-PGF2α ethyl amide in a dermatologically acceptable carrier. The topical formulation may be a cream, a gel, a lotion, a spray, an ointment, an aqueous solution, a nonaqueous solution, or a transdermal patch. The dermatologically acceptable carrier may contain an oily carrier or an aqueous carrier.

Подробнее
Номер записи: 87
04-10-2012 дата публикации

Combination composition comprising benzoyl peroxide and adapalene

Номер: US20120252897A1
Автор: Balakrishna Patro, Kamal Mehta, Lalatendu Panigrahi, Uday Kumar Nayak
Принадлежит: Glenmark Generics LTD

An aqueous gel composition of the present invention comprising about 0.1 to 0.3 wt % adapalene and about 2.5 to 5.0 wt % benzoyl peroxide, as active ingredients, wherein both the active ingredients are stabilized in hydrophilic gelling matrix of pH dependent gelling agent comprising crosslinked, acrylic acid-based polymer(s).

Подробнее
Номер записи: 88
04-10-2012 дата публикации

Drug delivery from rapid gelling polymer composition

Номер: US20120252905A1
Автор: Aniko Takacs-Cox, Arpita Maiti, David M. Gravett, Leanne Embree, Philip M. Toleikis
Принадлежит: Angiotech International AG

Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.

Подробнее
Номер записи: 89
11-10-2012 дата публикации

Device for transdermal administration of drugs including acrylic polymers

Номер: US20120258942A1
Автор: David Kanios
Принадлежит: Noven Pharmaceuticals Inc

A transdermal delivery system is provided where the drug delivery rates, onset and profiles of at least one active agent are controlled by selectively manipulating the monomeric make up of an acrylic-based polymer in the transdermal drug delivery system. The drug carrier composition may be comprised of (a) one or more acrylic-based polymers having one or more different monomers selected from the group consisting of hard and soft monomers; (b) one or more silicone-based polymers; and (c) one or more active agents where the device provides a desired solubility for the active agent and controls drug delivery rates, onset and profiles of at least one active agent.

Подробнее
Номер записи: 90
11-10-2012 дата публикации

Reagents, Methods and Systems to Suppress Pro-Inflammatory Cytokines

Номер: US20120258999A1
Автор: Jeffrey C. Marx
Принадлежит: WARSAW ORTHOPEDIC INC

The present invention relates to reagents, methods and systems to treat inflammation and pain in a subject using small interfering RNA (siRNA) molecules targeted to either TNFα, IL1 IL6 and other pro-inflammatory cytokines.

Подробнее
Номер записи: 91
11-10-2012 дата публикации

Self-assembled particles from zwitterionic polymers and related methods

Номер: US20120259021A1
Автор: Hong Xue, Lei Zhang, Shaoyi Jiang, Zhiqiang Cao
Принадлежит: University of Washington Center for Commercialization

Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles.

Подробнее
Номер записи: 92
11-10-2012 дата публикации

Pharmaceutical compositions providing enhanced drug concentrations

Номер: US20120259022A1
Автор: Douglas A. Lorenz, Dwayne T. Friesen, James A. S. Nightingale, Ravi M. Shanker, Walter C. Babcock, William J. Curatolo
Принадлежит: Bend Research Inc

A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

Подробнее
Номер записи: 93
18-10-2012 дата публикации

Implantable polymer for bone and vascular lesions

Номер: US20120263797A1
Автор: Andrew J. Carter, Arthur C. Watterson, Craig M. Jones, Jeffrey A. D'Agostino
Принадлежит: BIOS2 Medical Inc

A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

Подробнее
Номер записи: 94
18-10-2012 дата публикации

Dual lane coating

Номер: US20120263865A1
Автор: Beuford A. Bogue
Принадлежит: MONOSOL RX LLC

The present invention relates to methods and apparatuses for forming an active-containing film product, while significantly reducing the amount of wasted active material. The resulting product is an active-containing film product that meets the user's predetermined criteria of physical properties and is suitable for use.

Подробнее
Номер записи: 95
18-10-2012 дата публикации

Oligomeric compounds and excipients

Номер: US20120264806A1
Автор: Andrew M. Siwkowski, C. Frank Bennett, Eric E. Swayze, Richard S. Geary
Принадлежит: ISIS PHARMACEUTICALS INC

The present invention provides method of optimizing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.

Подробнее
Номер записи: 96
18-10-2012 дата публикации

Polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer

Номер: US20120264852A1
Автор: Ariane Vartanian, Susan P. James, Susan S. Yonemura
Принадлежит: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.

Подробнее
Номер записи: 97
25-10-2012 дата публикации

Medicinal Cream Made Using Hydrocortisone Acetate and A Process To Make The Same

Номер: US20120270835A1
Автор: Haridas Sankar, Kausik Ghosh, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Vanangamudi Subramaniam Sulur
Принадлежит: Apex Labs Private Ltd

The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of hydrocortisone acetate, used in treating skin inflammation c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and a corticosteroid in the form of hydrocortisone acetate, are incorporated in cream base for use in treating skin inflammation due to allergy & itching & wounds on human skin involving contacting human skin with the above identified composition.

Подробнее
Номер записи: 98
01-11-2012 дата публикации

Plasticized Elastomer Including a Volatile Compound

Номер: US20120273586A1
Автор: Mark Grodsky, Mark R. Shook
Принадлежит: Individual

A plasticized elastomer includes a polymeric carrier and a volatile compound, such as a fragrance, medicament, or antimicrobial, disposed in the polymeric carrier. The polymeric carrier absorbs microwave energy and slowly dissipates it as heat until the polymeric carrier reaches thermal equilibrium with the ambient temperature. The heat of the polymeric carrier increases a vapor pressure of the volatile compound, which boosting its evaporation into the ambient environment.

Подробнее
Номер записи: 99
01-11-2012 дата публикации

Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same

Номер: US20120276162A1
Автор: Greg Troiano, James Wright, Jeff Hrkach, Mir Mukkaram Ali, Stephen E. Zale
Принадлежит: Individual

The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.

Подробнее
Номер записи: 100