25-04-2013 дата публикации
Номер: US20130101662A1
Принадлежит:
Peptides of general formula (I): R—W—X-AA-AA-AA-AA-Y—Z—R(I) its stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, a preparation process, cosmetic or pharmaceutical compositions which contain them and their use in the treatment and/or care of the skin, mucous membranes and/or hair and the treatment and/or care of those conditions, disorders and/or diseases which are improved or prevented by Hsp stimulation. 1. A peptide of general formula (I){'br': None, 'sub': 1', 'm', '1', '2', '3', '4', 'p', 'q', '2, 'R—W—X-AA-AA-AA-AA-Y—Z—R\u2003\u2003(I)'}its stereoisomers, mixtures thereof and/or its cosmetically or pharmaceutically acceptable salts, wherein:{'sub': '1', 'AAis -His-;'}{'sub': '2', 'AAis selected from the group consisting of -His-, -Leu- and -Pro-'}{'sub': '3', 'AAis -Leu-;'}{'sub': '4', 'AAis selected from the group consisting of -Arg- and -Asn-;'}W, X, Y and Z are independently selected from amongst themselves from the group consisting of the codified amino acids and uncodified amino acids;n, m, p and q are independently selected from amongst themselves and have a value between 0 and 1;n+m+p+q is less or equal to 2;{'sub': 1', '5', '5, 'Ris selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R—CO— wherein Ris selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl;'}{'sub': 2', '3', '4', '3', '3', '3', '4, 'Ris selected from the group consisting of —NRR, —ORand —SR, wherein Rand Rare independently selected from the group ...
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