Поиск патентов

05-01-2012 дата публикации

Nanobead releasing medical devices

Номер: US20120003291A1

Автор: Charles H. Craig, Dennis Orosa, Dudley Jayasinghe, John E. Papp, Lionel G. Hines

Принадлежит: Abbott Cardiovascular Systems Inc

Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.

Подробнее

Номер записи: 1

05-01-2012 дата публикации

Hemostatic fibrous material

Номер: US20120004636A1

Автор: Denny Lo

Принадлежит: Denny Lo

This disclosure relates to devices for promoting the clotting of blood in human beings or animals, or hemostatic devices. These devices may comprise a fibrous material or materials comprising one or more fibers such as a gauze or a cloth. Some of the fibers in these materials or devices may comprise a macromolecular material and a hemostatic hemostatic additive material such as kaolin or another clay.

Подробнее

Номер записи: 2

12-01-2012 дата публикации

Blood coagulation inducing polymer hydrogel

Номер: US20120009242A1

Автор: Adam Behrens, Bartley P. Griffith, Brendan J. Casey, Peter Kofinas, Trevor A. Snyder

Принадлежит: University of Maryland at Baltimore, UNIVERSITY OF MARYLAND AT COLLEGE PARK

The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.

Подробнее

Номер записи: 3

12-01-2012 дата публикации

Particle Embedded Polymer Stent and Method of Manufacture

Номер: US20120010691A1

Автор: Gerry Clarke

Принадлежит: Medtronic Vascular Inc

A particle embedded polymer stent and method of manufacture, which includes a stent delivery system having a catheter; a balloon operably attached to the catheter; and a polymer stent disposed on the balloon, the stent comprising struts interconnected to form a tubular body. Each of the struts includes in cross section a drug-free core region; and a drug region surrounding and immediately adjacent to the core region, the drug region including drug particles. The drug-free core region and the drug region are made of a single polymer, the single polymer having a drug-safe softening temperature.

Подробнее

Номер записи: 4

19-01-2012 дата публикации

Compounds for the prevention and treatment of cardiovascular diseases

Номер: US20120015905A1

Автор: Henrik C. Hansen

Принадлежит: Resverlogix Corp

The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.

Подробнее

Номер записи: 5

02-02-2012 дата публикации

Drug Combinations Useful for Prevention of Restenosis

Номер: US20120029475A1

Автор: Gerald H. Llanos, Gregory A. Kopia, Robert Falotico

Принадлежит: Individual

The current invention comprises an approach to solving the clinical problem of restenosis, which involves the administration of combinations of drugs to patients undergoing PTCA or stent implantation. In one embodiment of the invention, an antiproliferative agent such as rapamycin, vincristine or taxol is administered in combination with the anti-inflammatory agent, dexamethasone, to patients systemically, either subcutaneously or intravenously. In another embodiment of the invention, the antiproliferative and anti-inflammatory agents are bound in a single formulation to the surface of a stent by means of incorporation within either a biodegradeable or biostable polymeric coating. Alternatively, such drug combinations could be incorporated into a stent constructed with a grooved reservoir.

Подробнее

Номер записи: 6

09-02-2012 дата публикации

Compounds and medical devices activated with solvophobic linkers

Номер: US20120035321A1

Автор: Philippe Gravagna, Sébastien LADET

Принадлежит: Sofradim Production SAS

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Подробнее

Номер записи: 7

16-02-2012 дата публикации

Novel biomaterials, their preparation and use

Номер: US20120040901A1

Автор: Christian Schoch, György Lajos KIS, Jozsef Szejtli, Lajos Szente

Принадлежит: Individual

The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

Подробнее

Номер записи: 8

16-02-2012 дата публикации

Biologic treatment system and method

Номер: US20120041418A1

Автор: Thomas Q. Dinh

Принадлежит: AMS Research LLC

A delivery system is provided that is adapted to treat various urological pelvic disorders, such as prolapse, incontinence, and the like. The delivery system can include at least one biologic loaded or otherwise provided with a bioactive agent. The biologic can comprise any drugs, hormones or steroids, stem cells, growth factors, proteins, and/or other bioactive agents to promote cell or tissue growth for the treatment and strengthening of organ walls or tissue. The biologic is generally adapted to controllably release the agent to the surrounding tissue or organ to provide a local and targeted delivery.

Подробнее

Номер записи: 9

23-02-2012 дата публикации

Method of stabilizing and sterilizing peptides or proteins

Номер: US20120045431A1

Автор: John T. Trogden, Robert T. Lyons

Принадлежит: Allergan Inc

The present invention provides a method for sterilizing a protein-containing bioerodible implant. The sterilization is accomplished using β-radiation, or high energy electrons. Following sterilization the implant can be used in a variety of methods for the sustained release of a therapeutic protein to treat a disease or condition in a human or non-human subject. The sterilization process is compatible with proteins containing one or more disulfide bonds or easily oxidized methionine residues.

Подробнее

Номер записи: 10

23-02-2012 дата публикации

Coating Comprising An Elastin-Based Copolymer

Номер: US20120046640A1

Автор: Lothar W. Kleiner, Syed F.A. Hossainy, Yiwen Tang

Принадлежит: Abbott Cardiovascular Systems Inc

The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.

Подробнее

Номер записи: 11

23-02-2012 дата публикации

Devices and methods for treating defects in the tissue of a living being

Номер: US20120046758A1

Автор: Douglas G. Evans, Russell T. Kronengold, Scott M. Goldman

Принадлежит: Evans Douglas G, Goldman Scott M, Kronengold Russell T

An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.

Подробнее

Номер записи: 12

01-03-2012 дата публикации

Balloon catheter devices with sheath covering

Номер: US20120053517A1

Автор: Ben Arcand, Colm McGuiness, Daniel Horn, Derek Sutermeister, Gordon Kocur, Jay Rassat, John Chen, Kent Harrison, Raed Rizq, Ruth Cheng, Tracee Eidenschink, Wendy Naimark

Принадлежит: Boston Scientific Scimed Inc

Catheter devices having an expandable balloon for delivering a therapeutic agent to a body site. In one aspect, one or more sheaths are disposed around the balloon with the therapeutic agent being disposed within the sheath, being disposed over the sheath, being contained in the space between the sheath and the balloon, or being otherwise associated with the sheath. In another aspect, the balloon includes a micro-electromechanical system (MEMS) for drug delivery.

Подробнее

Номер записи: 13

08-03-2012 дата публикации

Deodorizing Compositions

Номер: US20120058074A1

Автор: Thomas Daniel, Volker Braig

Принадлежит: BASF SE

The present invention relates to odor-inhibiting compositions comprising water-absorbing polymer particles and at least one oxidase.

Подробнее

Номер записи: 14

08-03-2012 дата публикации

Activated leukocyte composition and uses for wound healing

Номер: US20120058156A1

Автор: Adi Zuloff-Shani, Eilat Bain, Eilat Shinar, Irene Ginis, Marina Bubis, Mitchell Shirvan, Orit Frenkel

Принадлежит: Macrocure Ltd

Disclosed are therapeutic, blood-derived activated leukocyte compositions, methods of making them, and methods of using the compositions to repair or promote the prevention and healing of wounds.

Подробнее

Номер записи: 15

08-03-2012 дата публикации

Coating Process for Drug Delivery Balloons Using Heat-Induced Rewrap Memory

Номер: US20120059316A1

Автор: Dennis Larson, Michael S. Owens, Michael Swee, Stacie Blaskowsi

Принадлежит: Boston Scientific Scimed Inc

A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.

Подробнее

Номер записи: 16

08-03-2012 дата публикации

Method of Manufacturing a Polymeric Stent Having Reduced Recoil

Номер: US20120059451A1

Автор: Joseph H. Contiliano, Qiang Zhang

Принадлежит: Advanced Technologies and Regenerative Medicine LLC

Methods of manufacturing polymeric intraluminal stents, and stents made by such methods, are disclosed. The methods provide for manufacturing polymeric intraluminal stents by inducing molecular orientation in the stents by radial compression thereby providing stents with low recoil post-deployment.

Подробнее

Номер записи: 17

08-03-2012 дата публикации

Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor

Номер: US20120059462A1

Автор: Vernon G. Wong

Принадлежит: Allergan Inc

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

Подробнее

Номер записи: 18

15-03-2012 дата публикации

Absorbable adhesive paste

Номер: US20120064027A1

Автор: Shalaby W. Shalaby

Принадлежит: Poly Med Inc

An absorbable adhesive paste contains absorbable solid carboxy-bearing microparticles dispersed in a continuous phase of an alkoxyalkyl cyanoacrylate. The paste may contain a soluble absorbable polymeric viscosity modifier and at least one bioactive agent to maximize the effective application as a cover for compromised tissues and wounds or as sealants, blocking agents, or hemostatic agents.

Подробнее

Номер записи: 19

22-03-2012 дата публикации

Water-absorbing resin composition

Номер: US20120070484A1

Автор: Takayasu Taniguchi, Tatsuya Oida, Yasuhiro Nawata

Принадлежит: Individual

A water-absorbent resin composition having an antimicrobial property, which suppresses the generation of dust of the antimicrobial agent. A water-absorbent resin composition comprising a water-absorbent resin and an antimicrobial agent comprising an inorganic compound carrying an antimicrobial metal, the water-absorbent resin composition being characterized in that the degree of generated dust of the water-absorbent resin composition is at most 100 CPM. The water-absorbent resin composition of the present invention can be suitably used as hygienic materials such as disposable diaper, sanitary napkin and incontinence pad; urine-absorbent materials for pets; materials for civil engineering and construction such as packing materials; drip absorbents; food freshness retaining materials such as cold-reserving agents; horticultural articles such as water-retaining materials for soils; and the like.

Подробнее

Номер записи: 20

05-04-2012 дата публикации

Antimicrobial adhesive system

Номер: US20120083536A1

Автор: David D. Cox, Leland W. Annett, Robert E. Lund

Принадлежит: Individual

An adhesive composition having dispersed therein a broad spectrum antimicrobial agent for use in medical applications, such as an adhesive for surgical drapes, wound dressings and tapes, is provided. The adhesive is composed of acrylic polymers, tackifiers and a preferred antimicrobial agent, diiodomethyl-p-tolylsulfone. The subject adhesive composition may be formulated as either an essentially solventless hot melt, or as a solvent based system wherein an emulsion of the antimicrobial agent and the removal of excess solvent is avoided.

Подробнее

Номер записи: 21

05-04-2012 дата публикации

Apparatus and method for delivery of biological sealant

Номер: US20120083828A1

Автор: A. David Boccuti, Andrew Nicholas Gentile, Gary Whipple, J. Brent Ratz, John L. Wheeler, John Spiridigliozzi, Thomas T. Washburn

Принадлежит: Spinal Restoration Inc

A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.

Подробнее

Номер записи: 22

12-04-2012 дата публикации

Antimicrobial foam

Номер: US20120087966A1

Автор: Jan Frances HAVILAND

Принадлежит: OBE Goods LLC

A resilient foam material having an active antimicrobial bound to, incorporated within, and projecting from its surface is provided for incapacitating or destroying microbes. The antimicrobial has an atomic structure that is capable of mechanically piercing or lysing a microbe thereby incapacitating or destroying the microbe. The resilient antimicrobial foam material may be manufactured into a resilient antimicrobial foam product for drawing across a surface and mechanically incapacitating or destroying microbes on the surface. The resilient antimicrobial foam material may be manufactured into a membrane for providing a sterile barrier for a surface. The resilient antimicrobial foam material is manufactured by combining the antimicrobial with a foam polymer material, heating the foam polymer material under pressure to a temperate that does not deactivate the antimicrobial, incorporating a blowing agent, cooling the material, and extruding the material.

Подробнее

Номер записи: 23

12-04-2012 дата публикации

Wound healing device

Номер: US20120089084A1

Автор: Joe O'keeffe, John O'Donoghus, Liam O'Neil, Peter Dobbyn

Принадлежит: PLASMEDICA TECHNOLOGIES Ltd

A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface.

Подробнее

Номер записи: 24

12-04-2012 дата публикации

Implantable Drug Delivery Device with Bladder Retention Feature

Номер: US20120089121A1

Автор: Heejin Lee, Hong Linh Ho Duc

Принадлежит: Taris Biomedical Inc

Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder Which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.

Подробнее

Номер записи: 25

19-04-2012 дата публикации

Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration

Номер: US20120093914A1

Автор: Shai Yehoshua Schubert

Принадлежит: MOMA THERAPEUTICS

In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.

Подробнее

Номер записи: 26

26-04-2012 дата публикации

Osteoinductive bone graft injectable cement

Номер: US20120100225A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.

Подробнее

Номер записи: 27

03-05-2012 дата публикации

Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same

Номер: US20120107383A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustained release of the statin and facilitate bone formation and repair of the fracture site.

Подробнее

Номер записи: 28

03-05-2012 дата публикации

Apparatus for forming an implant

Номер: US20120107384A1

Автор: Ben Walthall, Jian Q. Yao, Jizong Gao, Victor Zaporojan

Принадлежит: Isto Technologies Inc, Zimmer Inc

Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.

Подробнее

Номер записи: 29

03-05-2012 дата публикации

Osteoconductive matrices comprising statins and methods of using the same

Номер: US20120107401A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.

Подробнее

Номер записи: 30

03-05-2012 дата публикации

Methods and compositions involving (s)-bucindolol

Номер: US20120108617A1

Автор: Jonathan D. Port, Michael R. Bristow

Принадлежит: Arca Biopharma Inc

Disclosed is bucindolol substantially free of its R-stereoisomer. Also disclosed are pharmaceutical compositions that include bucindolol substantially free of its R-stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also disclosed are methods of treating a patient that involve administering to the patient a therapeutically effective amount of a composition of the present invention. Formula (I).

Подробнее

Номер записи: 31

03-05-2012 дата публикации

Therapeutic agent delivery system and method for localized application of therapeutic substances to a biological lumen

Номер: US20120109105A1

Автор: Matthew David Cambronne

Принадлежит: Cardiovascular Systems Inc

The invention provides a system and method for localized application of therapeutic substances within a biological lumen and to the wall of the lumen. In various embodiments, a biodegradable tubular prosthesis comprising a plurality of pores is deployed within a biological lumen. Subsequent to, or in conjunction with, the deployment of the prosthesis, a drug-eluting balloon comprising at least one therapeutic agent is expanded within the lumen of the tubular prosthesis, thereby releasing the agent(s) from the balloon and delivering them to the prosthesis pores. The at least one therapeutic agent is then allowed to diffuse through the pores to the lumen wall.

Подробнее

Номер записи: 32

10-05-2012 дата публикации

Composite bone cements with a pmma matrix, containing bioactive antibacterial glasses or glassceramics

Номер: US20120115981A1

Автор: Alessandro Bistolfi, Alessandro Masse, Enrica Verne', Giovanni Maina, Marta Miola, Maurizio Crova, Sara Ferraris

Принадлежит: POLITECNICO DI TORINO, Universita degli Studi di Torino

A bone cement comprising an acrylic polymeric component and an inorganic component comprising a bioactive glass or glass-ceramic, comprising at least one metal oxide having an anti-bacterial activity, wherein said glass or glass-ceramic component is adapted to release ions of said metal in contact with physiological fluids. The bone cement performs a sustained antibacterial action, also promoting binding with the tissues with which it is contacted, and it is advantageously employed in the fixation of orthopaedic prostheses, in the production of temporary prostheses and in spinal surgery.

Подробнее

Номер записи: 33

10-05-2012 дата публикации

Joint device and method

Номер: US20120116523A1

Автор: Peter Forsell

Принадлежит: MILUX HOLDING SA

A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose. Further, a method of treating hip joint osteoarthritis in a human patient by providing an artificial hip joint surface using a mould is provided. The method comprises the steps of: said mould being placed inside of said hip joint, said mould being injected with a fluid adapted to harden, said fluid hardening inside of said hip joint, said mould being resorbed by the human body, and said hardened fluid serving as artificial hip joint surface.

Подробнее

Номер записи: 34

17-05-2012 дата публикации

Functionalized rgd peptidomimetics and their manufacture, and implant having a coating containing such functionalized rgd peptidomimetics

Номер: US20120121658A1

Автор: Alexander Borck, Florian Rechenmacher, Horst Kessler, Matthias Gratz, Michael Joner, Stefanie Neubauer

Принадлежит: BIOTRONIK AG

At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a functionalized RGD peptidomimetic RGD-P2 having the formula (2), and an associated manufacturing method.

Подробнее

Номер записи: 35

17-05-2012 дата публикации

Multiamino Acid-Based Poly(Ester Amide)s

Номер: US20120123064A1

Автор: Chih-Chang Chu, Mingxiao Deng

Принадлежит: CORNELL UNIVERSITY

Biodegradable saturated and unsaturated polyester amides (PEA)s made from multiamino acid monomers and methods of making biodegradable saturated and unsaturated PEAs.

Подробнее

Номер записи: 36

24-05-2012 дата публикации

Preparation of bone cement compositions

Номер: US20120129761A1

Автор: Eva Liden, Jeffrey C. Karr, Malin Nilsson, Veronica Sandell

Принадлежит: Bone Support AB

A method for the preparation of injectable ready-to-use paste bone cement compositions by mixing a dry inorganic bone cement powder comprising a particulate calcium sulfate hemihydrate capable of hardening in vivo by hydration of the calcium sulfate hemihydrate forming calcium sulfate dihydrate, an aqueous liquid and an additive that normally retards the setting process, said method comprising a) providing a bone cement powder comprising calcium sulfate hemihydrate, an accelerator for the hardening of the calcium sulfate hemihydrate by hydration, said accelerator being selected from the group consisting of saline and calcium sulfate dihydrate, and a powdered calcium phosphate component b) mixing the bone cement powder with the aqueous liquid for a period of time c) leaving the mixture for the time needed for allowing the hydration reaction of the calcium sulfate hemihydrate to proceed and allowing calcium sulfate dihydrate crystals to form and grow, and d) admixing the additive by means of a short-duration mixing using a minimum of energy surprisingly shortens the setting times for the cement comprising the additive that retard the setting process to the level observed in the absence of the additive and enables a complete hydration of calcium sulfate hemihydrate to calcium sulfate dihydrate, even when using additives else preventing the hardening.

Подробнее

Номер записи: 37

24-05-2012 дата публикации

Clay-based hemostatic agents and devices for the delivery thereof

Номер: US20120130296A1

Автор: Daniel J. Burns, Denny Lo, Francis X. Hursey, Giacomo Basadonna, Raymond J. Huey

Принадлежит: Z Medica LLC

A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Подробнее

Номер записи: 38

24-05-2012 дата публикации

Compositions and methods for arthrodetic procedures

Номер: US20120130435A1

Автор: Charles E. Hart, Samuel E. Lynch

Принадлежит: Biomimetic Therapeutics LLC

The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.

Подробнее

Номер записи: 39

31-05-2012 дата публикации

Wound dressing materials

Номер: US20120135062A1

Автор: Lorraine Nisbet

Принадлежит: Systagenix Wound Management US Inc

A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressing comprising the materials, methods of treatment with the materials, and methods of making the materials.

Подробнее

Номер записи: 40

07-06-2012 дата публикации

Cell coated implantable device

Номер: US20120141562A1

Автор: George A. Truskey, Hardean E. Achneck, Ryan M. Jamiolkowski

Принадлежит: Achneck Hardean E, Jamiolkowski Ryan M, Truskey George A

The present invention relates, in general, to a cell-coated implantable medical device and, in particular, to an implantable medical device the blood-contacting surfaces of which are coated with endothelial progenitor cells (EPCs). In a preferred embodiment, the medical device is a titanium or titanium alloy-based medical device.

Подробнее

Номер записи: 41

07-06-2012 дата публикации

Umbilical cord amniotic membrane products

Номер: US20120141595A1

Автор: Amy Tseng, Ek Kia Tan, Scheffer Tseng

Принадлежит: TissueTech Inc

Disclosed herein, in certain instances, are tissue grafts derived from UCAM. Further disclosed herein, in certain instances, are use for tissue grafts derived from UCAM.

Подробнее

Номер записи: 42

07-06-2012 дата публикации

Biomolecular coating for implants

Номер: US20120142597A1

Автор: Abigail M. Wojtowicz, Andres J. Garcia, Barbara D. Boyan, Catherine D. Reyes, David M. Collard, Jenny E. RAYNOR, Robert E. Guldberg, Timothy Petrie, Zvi Schwartz

Принадлежит: Georgia Tech Research Corp

Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α 2 β 1 or α 5 β 1 integrin-specific ligand are provided. The substrates and devices coated with an α 2 β 1 or α 5 β 1 integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.

Подробнее

Номер записи: 43

14-06-2012 дата публикации

Solid dressing for treating wounded tissue

Номер: US20120150087A1

Автор: Dawson Beall, Martin Macphee

Принадлежит: Dawson Beall, MACPHEE Martin

Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue.

Подробнее

Номер записи: 44

14-06-2012 дата публикации

Antimicrobial material and method for making the same

Номер: US20120150095A1

Автор: Michael Szycher

Принадлежит: Individual

This invention provides a modified catheter/indwelling device biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA) as an option, a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation. Alternatively, the sparsely soluble silver salt can be silver iodate and is combined with silver sulfadiazine. Chlorhexidine can also be included in the material.

Подробнее

Номер записи: 45

14-06-2012 дата публикации

Implantable or insertable medical devices for controlled drug delivery

Номер: US20120150096A1

Автор: Cang Duy Dao, Danielle Conley, Hamid Davoudi, Jianmin Li, Kathleen M Miller, Raymond J. Lareau, Weenna Bucay-Couto

Принадлежит: Boston Scientific Scimed Inc

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.

Подробнее

Номер записи: 46

14-06-2012 дата публикации

Drug Eluting Balloons with Ability for Double Treatment

Номер: US20120150142A1

Автор: Jan Weber, Jos Wetzels

Принадлежит: Boston Scientific Scimed Inc

In embodiments, medical devices, such as balloon catheters, can deliver a biologically active material to body tissue of a patient. The medical device includes a sponge delivery layer which can deliver multiple doses of one or more therapeutic agents to the body tissue. The medical device can further include a drug reservoir, which can supply the delivery layer with one or more therapeutic agents.

Подробнее

Номер записи: 47

14-06-2012 дата публикации

Adhesive Suture Structure and Methods of Using the Same

Номер: US20120150221A1

Автор: Frank J. Viola

Принадлежит: TYCO HEALTHCARE GROUP LP

According to an aspect of the present disclosure, a surgical suture needle assembly is provided including an elongate tube defining a lumen through at least a portion of a length thereof; and a wound treatment material contained within the lumen of the suture structure. The present disclosure further provides for methods of using the surgical suture needle assembly in anastomotic procedures and the like.

Подробнее

Номер записи: 48

21-06-2012 дата публикации

Antimicrobial compounds having protective or therapeutic leaving groups

Номер: US20120157373A1

Автор: Catherine E. Taylor, Jianwei Li, Linnus Cheruiyot, Matt Bergan, Paul Hsien-Fu Wu, Terese A. Bartlett

Принадлежит: MEDTRONIC INC

Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.

Подробнее

Номер записи: 49

21-06-2012 дата публикации

Absorbent article having releasable odor control

Номер: US20120157805A1

Автор: Magali Pourcel, Mariangela Caputi

Принадлежит: Procter and Gamble Co

An absorbent article comprises a topsheet, a backsheet, an absorbent core disposed between the topsheet and backsheet, and a cyclodextrin complex comprising cyclodextrin and at least three components complexed with the cyclodextrin. The absorbent article has a Total Headspace Area at Time 0 Minutes of no greater than about 0.50×10 8 , a Total Headspace Area at Time 30 Minutes of at least about 1.00×10 8 , and a Total Headspace Area at Time 240 Minutes of at least about 2.70×10 8 , as measured by the Headspace Test Method.

Подробнее

Номер записи: 50

28-06-2012 дата публикации

Coating method and coating device

Номер: US20120164312A1

Автор: Klaus-Dieter Kühn, Sebastian Vogt

Принадлежит: HERAEUS MEDICAL GMBH

A method for coating at least regions of a medical implant includes providing a medical implant having a surface to be coated, and immersing the surface of the medical implant into a liquid including at least one pharmaceutically active substance, whereby the liquid is transferred to the surface of the medical implant due to the immersing. The method also includes pulling the surface of the medical implant out of the liquid, whereby part of the liquid remains adhering to the surface of the medical implant.

Подробнее

Номер записи: 51

28-06-2012 дата публикации

Uveoscleral drug delivery implant and methods for implanting the same

Номер: US20120165933A1

Автор: David Haffner, Kenneth Curry

Принадлежит: Dose Medical Corp

Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.

Подробнее

Номер записи: 52

28-06-2012 дата публикации

Nonwoven tissue scaffold

Номер: US20120165939A1

Автор: Joseph J. Hammer, Mark Timmer, Shetty Dhanuraj, Sridevi Dhanaraj, Stephanie M. Kladakis

Принадлежит: DePuy Mitek LLC

A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.

Подробнее

Номер записи: 53

05-07-2012 дата публикации

Electrospun silk material systems for wound healing

Номер: US20120171256A1

Автор: David L. Kaplan, Scott E. Wharram, Stephen McCarthy, Xiaohui Zhang

Принадлежит: TUFTS UNIVERSITY, University of Massachusetts Foundation Inc

The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.

Подробнее

Номер записи: 54

05-07-2012 дата публикации

Novel Formulations of Volatile Anesthetics and Methods of Use for Reducing Inflammation

Номер: US20120171281A1

Автор: Danguole Spakevicius, Hatice Ozsoy

Принадлежит: University of Texas System

The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.

Подробнее

Номер записи: 55

05-07-2012 дата публикации

Antimicrobial raw material and method for manufacturing the same, and antimicrobial material

Номер: US20120171406A1

Автор: Hiroshi Mase, Koji Hirota

Принадлежит: Mitsui Chemicals Inc

Provided is an antimicrobial raw material having excellent antibacterial and corrosion-resistance properties, which can be directly formed as a film even on a plastic substrate with low heat-resistance or a substrate whereof the color or properties are likely to change due to heat, and this can be achieved at relatively low cost. The antimicrobial raw material is a laminated structure which comprises a substrate layer and a copper-tin alloy layer disposed on the substrate layer, and which has a thickness ranging from 5 nm to 200 nm. The substrate layer is made of resin, natural fiber, or paper, the resin having the deflection temperature under load being 115° C. or lower when measured in accordance with ASTM-D648-56 under a load of 1820 kPa. The copper-tin alloy layer contains over 60 at % but no more than 90 at % of copper and 10 at % or more but less than 40 at % of tin.

Подробнее

Номер записи: 56

05-07-2012 дата публикации

Progenitor endothelial cell capturing with a drug eluting implantable medical device

Номер: US20120172970A1

Автор: Margaret Yoklavich, Robert John Cottone, Jr., Sherry Parker

Принадлежит: Orbus Medical Technologies Inc

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

Подробнее

Номер записи: 57

12-07-2012 дата публикации

Nano silver-zinc oxide composition

Номер: US20120177713A1

Автор: Rainer Xalter, Thomas Weiss

Принадлежит: POLYMERS CRC LTD

A new composite comprises (a) 10.1-99.9% by weight of elemental Ag and (b) 0.1-89.9% by weight of ZnO, wherein the sum of (a) and (b) makes 90% or more by weight of the composite and wherein the elemental Ag has a primary particle size of 10-200 nm and/or the ZnO has a primary particle size of 0.1 to below 50 μm and/or the composite has a particle size distribution of 0.1-50 μm and/or a BET surface area of 10-100 m2/g. The novel composite may be obtained by the steps (i) mixing a first mixture of at least one Ag-salt with a second mixture of at least one Zn-salt thereby forming a third mixture of Ag- and Zn-salts, (ii) adding the third mixture to a mixture of a carbonate source, (iii) co-precipitating of the Ag- and Zn-carbonates formed in step (ii), (iv) washing of the Ag- and Zn-carbonates and (v) thermal decompositing of the Ag- and Zn-carbonates. The novel composites are useful to impart antimicrobial properties to surfaces, articles or bulk compositions, especially to membrane systems for gas- or water separation.

Подробнее

Номер записи: 58

19-07-2012 дата публикации

Low viscosity liquid polymeric delivery system

Номер: US20120183629A1

Автор: Richard L. Dunn

Принадлежит: DUNN RES AND CONSULTING LLC

Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.

Подробнее

Номер записи: 59

19-07-2012 дата публикации

Polymer coating comprising 2- methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization

Номер: US20120184029A1

Автор: Charlotte Juel, Katja Jankova Atanasova, Søren Hvilsted

Принадлежит: Danmarks Tekniskie Universitet

The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerization (SI ATRP) such as ARGET SI ATRP or AGET SI ATRP and uses of said polymer coating.

Подробнее

Номер записи: 60

19-07-2012 дата публикации

Supporting and Forming Transitional Material for Use in Supporting Prosthesis Devices, Implants and to Provide Structure in a Human Body

Номер: US20120184974A1

Автор: Hilton Becker

Принадлежит: Individual

A biocompatible fabric comprised of a strong absorbable material and ultra fine permanent fibers which serve as a collagen support system for prosthesis devices and implants. The permanent fibers stimulate the growth of collagen but are too weak to offer the initial support desired. As the absorbable material dissolves, the collagen formed over the permanent fiber assumes the support role from the absorbable material. The supporting system is natural in appearance and motion without encapsulation or rigidity. The absorbable material can be overlaid with the non-absorbable fiber which after absorption leaves the non-absorbable mesh in an array. The fibers can be discontinuous, loosely woven or embedded in an absorbable material and can be patterned to provide various strengths and degrees of motion and movement. The materials can be coated or infused with materials to reduce infection, provide tissue growth, reduce scar tissue or other medicinal purposes.

Подробнее

Номер записи: 61

26-07-2012 дата публикации

Compositions and improved soft tissue replacement methods

Номер: US20120189708A1

Автор: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im

Принадлежит: Allergan Inc

The specification discloses compositions and methods for treating a soft tissue defect of an individual.

Подробнее

Номер записи: 62

26-07-2012 дата публикации

Viscoelastic gels as novel fillers

Номер: US20120190644A1

Автор: Davide RENIER, Matteo D'este

Принадлежит: Fidia Farmaceutici SpA

Biomaterials obtainable by mixing the autocrosslinked derivative of hyaluronic acid (ACP) with the derivative (HBC) of hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (BDDE) in the weight ratio of between 10:90 and 90:10 as novel fillers.

Подробнее

Номер записи: 63

02-08-2012 дата публикации

Therapeutic Inhibitor of Vascular Smooth Muscle Cells

Номер: US20120195951A1

Автор: Lawrence L. Kunz, Peter G. Anderson

Принадлежит: Individual

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.

Подробнее

Номер записи: 64

02-08-2012 дата публикации

Implantable devices

Номер: US20120195958A1

Автор: Faisal Sharif, Jim Crowley, Sean Hynes, Timothy O'brien, Udo Greiser

Принадлежит: National University of Ireland Galway NUI

The present invention relates to implantable devices, which are coated or coatable with liposomes. The present invention further relates to liposomes encapsulating nucleic acids termed lipoplexes, to methods for the manufacture and coating of such implantable devices, and to the use of such implantable devices to improve treatment of patients with coronary artery disease or other vascular diseases and cancers.

Подробнее

Номер записи: 65

09-08-2012 дата публикации

Method of preparing a packaged antimicrobial medical device

Номер: US20120199502A1

Автор: Howard Scalzo, James R. Mcdivitt, Jerome A. Fischer, Robert Cerwin, Stephen Rothenburger

Принадлежит: Ethicon Inc

A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

Подробнее

Номер записи: 66

09-08-2012 дата публикации

Medical product comprising a chitosan-coated wall and a method for manufacturing a medical product

Номер: US20120203326A1

Автор: Rivelino Montenegro, Thomas Freier

Принадлежит: MEDOVENT GMBH

A method for manufacturing a medical product comprising a hollow body ( 2 ), wherein at least part of a wall of the hollow body ( 2 ) is coated at least on the inside with a layer comprising a polymer; at least the part of at least the inside of the wall of the medical product is brought into contact with a mixture ( 6 ) of the polymer and the polymer is deposited from the mixture ( 6 ) on at least the part of the inside of the wall. And a medical product comprising a hollow body ( 2 ) with a wall consisting of one or more structural elements ( 16 ), at least a section of the wall being coated with a layer ( 15 ) comprising native chitosan, wherein both on the inside and the outside of the hollow body ( 2 ) at least some of the one or more structural elements ( 16 ) of the wall of the hollow body ( 2 ) are at least partly coated with the native chitosan layer ( 15 ). And a method for electrodepositing a polymer on an electrode from an acidic mixture of the polymer, wherein the mixture ( 6 ) comprises a multibasic acid.

Подробнее

Номер записи: 67

16-08-2012 дата публикации

Composite material with properties of self-healing and release of active ingredients, for biomedical applications

Номер: US20120208895A1

Автор: Anna Calarco, Gianfranco Peluso, Liberata Guadagno, Loredana Tammaro, Marialuigia Raimondo, Orsolina Petillo, Sabrina Margarucci, Vittoria Vittoria

Принадлежит: Gianfranco Peluso, Vittirua Vuttirua

This invention relates to a composite material for biomedical applications, in particular dental applications, which possesses self-healing capacity and is able to incorporate a system for the release of active ingredients at the stage of application and use.

Подробнее

Номер записи: 68

16-08-2012 дата публикации

Drug eluting implantable medical device with hemocompatible and/or prohealing topcoat

Номер: US20120209371A1

Автор: Lothar W. Kleiner, Yiwen Tang

Принадлежит: Abbott Cardiovascular Systems Inc

The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases.

Подробнее

Номер записи: 69

23-08-2012 дата публикации

Process for demineralization of bone matrix with preservation of natural growth factors

Номер: US20120213859A1

Автор: Benjamin P. Luchsinger, Darrel L. Holmes, Gregory A. Juda, Jesus Hernandez, Kelly R. Kirker, Nancy J. Shelby, Steven M. Scott

Принадлежит: Bacterin International Inc

A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

Подробнее

Номер записи: 70

30-08-2012 дата публикации

Methods Of Drug Loading A Hollow Stent With A High Viscosity Formulation

Номер: US20120216905A1

Автор: Stephen D. Pacetti

Принадлежит: Abbott Cardiovascular Systems Inc

A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may include a therapeutic agent. In some embodiments, the composition has characteristics such that at a temperature of 20° C. to 30° C. and a pressure of one atmosphere, the viscosity of the composition is about 10 cP or greater than 10 cP.

Подробнее

Номер записи: 71

30-08-2012 дата публикации

Materials for soft and hard tissue repair

Номер: US20120221118A1

Автор: Barry K. Bartee, Richard A. Rosen

Принадлежит: OBI BIOLOGICS Inc

Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention.

Подробнее

Номер записи: 72

13-09-2012 дата публикации

Conditioned cell culture medium compositions and methods of use

Номер: US20120230940A1

Автор: Andreas Kern, Anthony Ratcliffe, David L. Horwitz, Gail K. Naughton, Joan Zeltinger, Jonathan N. Mansbridge, Lee K. Landeen, Mark A. Applegate, R. Emmett Pinney

Принадлежит: Skinmedica Inc

Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.

Подробнее

Номер записи: 73

13-09-2012 дата публикации

Tissue transplant compositions and methods for use

Номер: US20120230966A1

Автор: John M. Garvey, Keith D. Crawford, Pamela Layton

Принадлежит: Brigham and Womens Hospital Inc, PARCELL LABS LLC

Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult stem cells (ELA cells). Also provided is a method for augmenting formation of tissues and organs by administering a transplant having ELA stem cells or combination of ELA stem cells.

Подробнее

Номер записи: 74

13-09-2012 дата публикации

Narrow profile composition-releasing expandable medical balloon catheter

Номер: US20120232640A1

Автор: Ronald Adrianus Maria Horvers

Принадлежит: Blue Medical Devices BV

The present invention relates to a composition-eluting balloon catheter ( 100 ) having a proximal ( 20 ) and distal ( 15 ) end, comprising an elongated catheter tube ( 6 ) with an inflation lumen ( 7 ) extending therewithin and at least one inflatable balloon ( 4 ) towards the distal end ( 15 ) in fluid communication with the inflation lumen ( 7 ), wherein the balloon ( 4 ) in the uninflated condition is provided as one or a plurality of folded wings ( 10′, 10 ″), and composition ( 12′, 12 ″) is provided essentially exclusively within the folds of the wings ( 10′, 10 ″), wherein the balloon ( 4 ) in the uninflated condition is further provided with a relief structure ( 30 ) comprising at least one groove on the outside of the folded wings ( 10′, 10 ″), configured to substantially reduce in depth in an inflated state of the balloon ( 4 ), and whereby the at least one groove is essentially devoid of composition ( 12′, 12 ″).

Подробнее

Номер записи: 75

27-09-2012 дата публикации

Mesh enclosed tissue constructs

Номер: US20120244617A1

Автор: Arash Kheradvar, Seyedhamed Alavi

Принадлежит: UNIVERSITY OF CALIFORNIA

Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.

Подробнее

Номер записи: 76

27-09-2012 дата публикации

Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds

Номер: US20120245540A1

Автор: Dmitry Zimnitsky, Jenny Finkbiner

Принадлежит: Individual

According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a homogenous mixture, such as a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension or applied on a carrier material, such as a bandage, gauze, foam, sponge, hydrogel, hydrocolloid, hydrofiber, occlusive dressing, adhesive composition or scaffold. Methods for producing such a topical composition and carrier material with the topical composition applied thereto are also disclosed.

Подробнее

Номер записи: 77

27-09-2012 дата публикации

Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents

Номер: US20120245677A1

Автор: Wayne H. Kaesemeyer

Принадлежит: PALMETTO PHARMACEUTICALS LLC

The present invention relates to a bioresorbable scaffold for a vascular stent comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone. The nitric oxide agonist is a statin or a HMG CoA reductase inhibitor. The nitric oxide agonist may be coated on the polymer, incorporated within the polymer or chemically bonded to the polymer. The invention also relates to a method for treating atherothrombosclerotic occlusive disease of an artery comprising implanting into the artery a stent with a bioresorbable scaffold comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone, wherein the nitric oxide agonist is exuded from or released from the bioresorbable scaffold.

Подробнее

Номер записи: 78

04-10-2012 дата публикации

Drug delivery from rapid gelling polymer composition

Номер: US20120252905A1

Автор: Aniko Takacs-Cox, Arpita Maiti, David M. Gravett, Leanne Embree, Philip M. Toleikis

Принадлежит: Angiotech International AG

Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.

Подробнее

Номер записи: 79

04-10-2012 дата публикации

Compositions for bone tissue repair and uses thereof

Номер: US20120253470A1

Автор: Kevin A. Guze, Vinicius Souza Rodrigues

Принадлежит: Harvard College

The technology described herein relates to compositions for promoting bone growth or regeneration. The compositions described herein can comprise bioactive agents and scaffold materials.

Подробнее

Номер записи: 80

11-10-2012 дата публикации

Transdermal therapeutic systems containing 4-n-butylresorcinol

Номер: US20120259020A1

Автор: Cathrin Scherner, Karl-Heinz Woeller, Ludger Kolbe, Rainer Wolber

Принадлежит: Beiersdorf AG

Transdermal therapeutic systems that contain 4-n-butylresorcinol as an active ingredient.

Подробнее

Номер записи: 81

18-10-2012 дата публикации

Coating Comprising An Elastin-Based Copolymer

Номер: US20120263759A1

Автор: Lothar W. Kleiner, Syed F.A. Hossainy, Yiwen Tang

Принадлежит: Abbott Cardiovascular Systems Inc

A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.

Подробнее

Номер записи: 82

18-10-2012 дата публикации

Implantable polymer for bone and vascular lesions

Номер: US20120263797A1

Автор: Andrew J. Carter, Arthur C. Watterson, Craig M. Jones, Jeffrey A. D'Agostino

Принадлежит: BIOS2 Medical Inc

A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

Подробнее

Номер записи: 83

25-10-2012 дата публикации

Marked precoated medical device and method of manufacturing same

Номер: US20120271248A1

Автор: Bruce Nesbitt, Charles Berkelhamer

Принадлежит: Innovatech Inc

A method of manufacturing a coated medical device, such as a medical guide wire, including at least applying a first colored coating to at least a first portion of an outer surface of a medical guide wire, securing a first end of the medical guide wire, and for each a designated quantity of turns, turn a second end of the medical guide wire upon a longitudinal axis of the medical guide wire. The method of manufacturing also includes securing the second end of the medical guide wire, blocking at least a first portion of the coated surface of the medical guide wire, applying a second contrasting colored coating to at least a second, unblocked portion of the outer surface of the medical guide wire and releasing the first end and the second end of the medical guide wire to display at least one spiral marking formed along a length of the medical guide wire.

Подробнее

Номер записи: 84

01-11-2012 дата публикации

Vhh for application in tissue repair, organ regeneration, organ replacement and tissue engineering

Номер: US20120276103A1

Автор: Clemens Antoni Van Blitterswijk, Cornelis Theodorus Verrips, Emilie Dooms Rodrigues, Hermanus Bernardus Johannes Karperien, Jan De Boer, Mohamed El Khattabi, Renee De Bruin

Принадлежит: Twente Universiteit, Universiteit Utrecht Holding BV

The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.

Подробнее

Номер записи: 85

01-11-2012 дата публикации

Absorbent material

Номер: US20120276183A1

Автор: Colin Bradford

Принадлежит: Individual

An absorbent product intended particularly for use as a wound dressing comprises an admixture of carboxymethyl chitosan and chitosan wherein the chitosan incorporates at least one antimicrobial agent. Absorbency is provided by the carboxymethyl chitosan and antimicrobial properties by the antimicrobial agent incorporated in the chitosan.

Подробнее

Номер записи: 86

01-11-2012 дата публикации

Soluble coating comprising polyelectrolyte with hydrophobic counterions

Номер: US20120276185A1

Автор: Lothar W. Kleiner, Mikael O. Trollsas, Syed F.A. Hossainy

Принадлежит: Individual

The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.

Подробнее

Номер записи: 87

01-11-2012 дата публикации

Bone Growth Compositions and Methods

Номер: US20120276204A1

Автор: Benjamin J. REMINGTON, David J. Bearss, Kavian Shahi

Принадлежит: NeuroPro Technologies Inc

The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to the site by a non-compressible delivery vehicle. The invention is suitable for promoting non-anatomic or heterotopic bone growth between any bony surfaces where bone growth is desired but does not naturally occur.

Подробнее

Номер записи: 88

01-11-2012 дата публикации

Hppe yarns

Номер: US20120277772A1

Автор: Claudia Maria Vaz, Edith Elizabeth Van Den Bosch, Gerardus Aben

Принадлежит: DSM IP ASSETS BV

The invention relates to a treated HPPE yarn characterized in that the treated HPPE yarn comprises: a porous polyolefin layer that adheres to a surface of a HPPE yarn and covers at least partly the surface of the HPPE yarn; a composition comprising an active agent and which composition is at least partially absorbed within the porous polyolefin layer. The invention further relates to an article comprising the treated HPPE yarn, a device comprising the treated HPPE yarn or the article. The invention also relates to a process for preparing the treated HPPE yarn or treated HPPE yarn structure or treated HPPE yarn configuration and use of the treated HPPE yarn or an article or a device comprising the treated HPPE yarn for automotive applications, marine applications, aerospace applications, medical applications, defense applications, sports/recreational applications, architectural applications, clothing applications, bottling applications, machinery applications.

Подробнее

Номер записи: 89

08-11-2012 дата публикации

Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering

Номер: US20120282321A1

Автор: Kelman I. Cohen, Yousef Mohajer

Принадлежит: Individual

Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration.

Подробнее

Номер записи: 90

08-11-2012 дата публикации

Helical hybrid stent

Номер: US20120283817A1

Автор: Jacob Richter

Принадлежит: Medinol Ltd

An expandable helical stent is provided, wherein the stent may be formed of an amorphous metal alloy or other non-amorphous metal with a securement. The stent is formed from flat or tubular metal in a helical coiled structure which has an undulating pattern. The main stent component may be formed of a single helically coiled component. Alternatively, a plurality of helically coiled ribbons may be used to form a stent heterogeneous in design, material, or other characteristic particular to that stent. The helical tubular structure may be secured with a securement, such as a weld, interlock or a polymer, to maintain the helical coils in a tubular configuration. The helical coils of the main stent component may be spaced apart or nestled to each other to maintain the tubular shape of the helically coiled stent and prevent the polymer layer from sagging at any point between cycles of the coils.

Подробнее

Номер записи: 91

08-11-2012 дата публикации

Antithrombotic and anti-restenotic drug eluting stent

Номер: US20120283822A1

Автор: Jonathon Z. Zhao, JR.

Принадлежит: Cordis Corp

An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different beneficial agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different beneficial agents may also be used to address different diseases, such as restenosis and acute myocardial infarction from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis.

Подробнее

Номер записи: 92

22-11-2012 дата публикации

Method and device for loading medical appliance with medicaments and/or polymers

Номер: US20120294499A1

Автор: Bo YI, Changsheng Wu, Jie Zhang, Qiyi Luo, Zhirong Tang

Принадлежит: Microport Medical Shanghai Co Ltd

A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

Подробнее

Номер записи: 93

22-11-2012 дата публикации

Tape having pattern of adhesive layers

Номер: US20120295054A1

Автор: John A. HOPE

Принадлежит: PERFORMTEX PRODUCTS LLC

An adhesive tape includes a base material and a plurality of adhesive layers disposed on a first side of the base material. A plurality of exposed base material areas separate the plurality of adhesive layers, such that when the adhesive tape is viewed from the first side, the plurality of exposed base material areas appear to be a plurality of intersecting lines.

Подробнее

Номер записи: 94

06-12-2012 дата публикации

Use of bacterial polysaccharides for biofilm inhibition

Номер: US20120308632A1

Автор: Jaione Valle, Jean-Marc Ghigo, Sandra Da Re

Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut Pasteur de Lille

A method comprises preventing or inhibiting bacterial adhesion and/or bacterial biofilm development by treating a substrate with a composition of a soluble group II capsular polysaccharide obtained from a bacterial strain.

Подробнее

Номер записи: 95

06-12-2012 дата публикации

Localized delivery of drug agents

Номер: US20120310159A1

Автор: Charles D. Lennox

Принадлежит: Boston Scientific Scimed Inc

Medical devices including a substrate that are expandable from a compressed state to an expanded state; a coating on the substrate, the coating having a drug agent incorporated therein; and a sheath over the coating. The sheath is expandable from a compressed state to an expanded state and has at least one perforation therein. The medical devices are configured such that when the substrate is in a compressed state, the sheath is also in a compressed state and the perforation is substantially closed. When the substrate is in an expanded state, the sheath is also in an expanded state and the perforation is substantially open. The invention also includes a method of using the medical devices for the controlled, localized delivery of a drug agent to a target location within a mammalian body.

Подробнее

Номер записи: 96

06-12-2012 дата публикации

In-situ intervertebral fusion device and method

Номер: US20120310352A1

Автор: John D. Malone, Thomas M. DiMauro

Принадлежит: DePuy Spine LLC

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

Подробнее

Номер записи: 97

13-12-2012 дата публикации

combination for the treatment of osteoarthritis

Номер: US20120316217A1

Автор: Arborio Mella Isabella, Edoardo Carlo Maria Conti, Francesco Saverio Dioguardi, Franco Conti, Giovanni Federico Maria Conti

Принадлежит: Professional Dietetics SpA

The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of osteoarthritis.

Подробнее

Номер записи: 98

13-12-2012 дата публикации

Prophylactic bactericidal implant

Номер: US20120316655A1

Автор: Richard A. Wysk, Thomas A. Fuller, Wayne J. Sebastianelli

Принадлежит: ArgentumCidalElectrics Inc

A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.

Подробнее

Номер записи: 99

20-12-2012 дата публикации

Clay-based hemostatic agents and devices for the delivery thereof

Номер: US20120321691A1

Автор: Daniel J. Burns, Denny Lo, Francis X. Hursey, Giacomo Basadonna, Raymond J. Huey

Принадлежит: Z Medica LLC

A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

Подробнее

Номер записи: 100

Настройки

Небесная энциклопедия

Мониторинг СМИ

Форма поиска