ГЕМОСТАТИЧЕСКАЯ ГУБКА

FIELD: medicine. SUBSTANCE: group of inventions relates to medicine. Described is haemostatic porous composite sponge, containing biomaterial matrix and one hydrophilic polymer component, containing reactionable groups, with matrix and polymer component connecting with each other in such a way that reactionable ability of polymer component remains, and "connected" means that said polymer component is applied on the surface of said biomaterial matrix or said matrix is soaked with said polymer material, or both. EFFECT: sponge demonstrates low swelling after application on wound. 15 cl, 9 dwg, 27 ex, 1 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61L 15/22 A61L 15/42 A61L 15/58 A61L 24/00 A61L 24/04 A61L 26/00 (13) 2 562 569 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012147275/15, 07.04.2011 (24) Дата начала отсчета срока действия патента: 07.04.2011 (72) Автор(ы): ХЕДРИХ Ганс Христиан (AT), ХЁФИНГХОФФ Йорис (AT) 07.04.2010 US 61/321,661; 16.12.2010 US 61/424,031 R U (73) Патентообладатель(и): БАКСТЕР ИНТЕРНЭШНЛ ИНК. (US), БАКСТЕР ХЕЛТКЭАР С.А. (CH) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 20.05.2014 Бюл. № 14 2 5 6 2 5 6 9 (45) Опубликовано: 10.09.2015 Бюл. № 25 (56) Список документов, цитированных в отчете о поиске: US 2008/187591 A1, 07.08.2008 . WO 90/ 13320 A1, 15.11.1990 . RU 2193897 C2, 10.12.2002 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 07.11.2012 (86) Заявка PCT: 2 5 6 2 5 6 9 R U (87) Публикация заявки PCT: C 2 C 2 EP 2011/055418 (07.04.2011) WO 2011/124640 (13.10.2011) Адрес для переписки: 109012, Москва, ул. Ильинка, 5/2, ООО "Союзпатент" (54) ГЕМОСТАТИЧЕСКАЯ ГУБКА (57) Реферат: Группа изобретений относится к медицине. Описана гемостатическая пористая композитная губка, содержащая матрицу из биоматериала и один гидрофильный полимерный компонент, содержащий реакционно- ...

ХИТОЗАНОВЫЕ КОМПОЗИЦИИ

... 1. Ортопедическая композиция, содержащая пористые частицы хитозана, суспендированные в жидкой среде, где указанная жидкая среда дополнительно содержит биосовместимый полимер. 2. Ортопедическая композиция по п.1, где частицы имеют размер частиц от 10 мкм до 2 мм. 3. Ортопедическая композиция по п.1, где частицы состоят из смеси хитозана вместе с производными хитозана, полисахаридами и/или белками. 4. Ортопедическая композиция по п.3, где указанные производные выбраны из сульфатированного хитозана, N-карбоксиметилхитозана, O-карбоксиметилхитозана и N,О-карбоксиметилхитозана. 5. Ортопедическая композиция по п.1, где указанные частицы содержат по меньшей мере 50% хитозана. 6. Ортопедическая композиция по п.1, где указанные частицы содержат от 50 до 90% хитозана. 7. Ортопедическая композиция по п.1, где жидкая среда дополнительно содержит пластификатор. 8. Ортопедическая композиция по п.7, где пластификатор представляет собой глицерин. 9. Ортопедическая композиция по п.1, где биосовместимый ...

УСТРОЙСТВО СБОРА ВЫДЕЛЕНИЙ ОРГАНИЗМА

... 1. Устройство сбора выделений организма, содержащее пакет сбора и клейкую прокладку для прикрепления к коже, при этом указанная прокладка содержит защитный слой, первый слой и второй слой гидроколлоидного клейкого вещества, где второй слой гидроколлоидного клейкого вещества, по меньшей мере, частично расположен между первым слоем гидроколлоидного клейкого вещества и защитным слоем, при этом первый и второй слои клейкого вещества состоят из непрерывной и прерывной фазы, в которомa) прерывная фаза первого слоя клейкого вещества содержит пектин, карбоксиметилцеллюлозу, желатин, гуаровую камедь и картофельный крахмал,b) прерывная фаза второго слоя клейкого вещества содержит карбоксиметилцеллюлозу, желатин и гуаровую камедь,c) состав непрерывной фазы первого слоя клейкого вещества содержит полиизобутилен, стирол блок-сополимер, бутилкаучук и реагент, придающий клейкость,d) состав непрерывной фазы второго слоя клейкого вещества содержит полиизобутилен и стирол блок-сополимер.2. Устройство сбора ...

Zusammensetzung zur Behandlung von Knochen

Silicone adhesive compositions and their use in securing medical appliances to mammalian body

ADHESIVE SKIN BARRIER

Silicone adhesive compositions and their use in securing medical appliances to mammalian body

An adhesive composition comprises: 50-90 wt% of uncured silicone gel adhesive comprising a blend of a polyorganosiloxane with at least one aliphatically unsaturated group, an organosiloxane with at least one silicone-hydride group and an addition curing catalyst; 1-50 wt% of a non-silicone hydrophilic liquid additive; 0.1-10 wt% of a cohesive strengthening agent; and trace-20 wt% of at least one siloxane resin. Claimed is the adhesive as an ostomy adhesive and as an adhesive wound dressing. The adhesive may be coated on a skin surface or peri-skin of a mammalian body and then cured. The invention is a skin friendly silicone adhesive which may be used to secure medical appliances to mammalian body and to protect and treat peri-skin surface.

Silicone adhesives to secure medical appliances to mammalian body

Skin compatible silicone composition

COMPOSITION FOR THE TREATMENT OF BONES

KNOCHENZEMENTVERBUNDSTOF

FABRIC REPAIR AND REPLACEMENT

DENTALWERKSTOFF

DIFERENTIELL BIODEGRADABLE MEDICAL INPLANTATE

Solvent deposition system and methods

A hemostatic device comprising a biomaterial matrix and a polymeric material prepared by combining the polymeric material with a solvent, applying the combination to the biomaterial, removing the solvent, and retaining an effective layer of the polymeric material to the biomaterial to enhance the performance of the hemostatic device in the treatment of wounds.

Random and non-random alkylene oxide polymer alloy compositions

Tissue repair and replacement

C \NRPonblDCOCJW05299_lDOC-2/32lI10 Tissue fixation devices are provided. The devices include a first component and a second component, the components having different rates of in vivo degradation. The first 5 component and second component are arranged so that, upon degradation of one of the components, the other component provides a scaffold into which bone can grow.

Liposomal drug delivery system for bone cements

The invention relates to a novel antibiotic delivery vehicle for impregnating bone cement wherein said vehicle is an antibiotic encapsulated liposome having a block co-polymer on its surface; a method for the manufacture of a bone cement impregnated with antibiotic or a mixture of antibiotics using said vehicle; and also a novel bone cement made therewith and/or thereby.

COMPOSITION FOR FILLING BONE DEFECTS

The invention is directed toward a formable bone composition for application to a bone defect site to promote new bone growth at the site whi ch comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles: The particle size ranges from about 0.1 mm to abou t 1.0cm and is mixed in a hydrogel carrier containing a sodium phosphate salin e buffer, the hydrogel component of the carrier ranging from about 1.0 to 5.0% of the composition and a pH between 6.8-7.4 with one or more additives of a cellular material, growth factor, demineralized bone chips or mineralized bone chips.

ADHESIVE COMPOSITION AND FIXATION ELEMENT FOR HUMAN SKIN

L'invention a pour objet une composition adhésive destinée à assurer la fixation sur la peau humaine, comprenant une phase continue et une phase discontinue d'hydrocolloïdes, la phase continue comprenant en poids, sur la base du poids total de la composition adhésive : (i) 1 à 12% en poids d'un polymère séquencé de type styrène-isoprène-styrène ou styrène-butadiène-styrène, (i i) (a) 1 à 15% d'un polymère de type élastomère butyl, éventuellement en mélange avec jusqu'à 25% en poids de d'un polymère de type polyisobutylène, ou (b) plus de 10% à 30% d'un polymère de type polyisobutylène, exempt de polymère de type élastomère butyl, (iii) 1 à moins de 10% d'un polymère de type éthylène vinyl acétate, la somme de ces trois types de polymères représentant de 10 à 40%. 11 ...

MALLEABLE PASTE FOR FILLING BONE DEFECTS

The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier, the hydrogel component of the carrier ranging from about 0.3 to 3.0% of the composition and having a molecular weight of about at least 10,000 Daltons. The composition contains about 25% to about 4 0% bone powder and can be additionally provided with BMP's and a sodium phosphate buffer.

ADHESIVE DRESSING SEALED

CEMENTO ÓSSEO, E, MÉTODO PARA FORMAR O MESMO.

BONE PASTE

Porous bone replacement materials

A process for the preparation of porous bone replacement materials which have a partly or completely interconnecting pore system with a volume content of 5 to 60%. The bone replacement material is prepared from a mixture of a solid component, a liquid component based on acrylate/methacrylate and coarse-particled granules of a biocompatible material with an average particle diameter of 0.5 to 10 mm.

Method and apparatus to control the heterogeneous flow of bone cement and improve osseointegration of cemented implant

The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.

Single component bone cement pastes and method for their hardening

Einkomponenten-Knochenzementpasten, enthaltend: AI mindestens ein radikalisch polymerisierbares Methacrylatmonomer; AII mindestens ein in AI lösliches Polymer; AIII mindestens ein in AI nicht lösliches partikuläres Polymer mit einer Partikelgröße kleiner 500 µm; optional AIV mindestens einen aktivierbarer Initiator, insbesondere mindestens einen radikalbildenden Initiator oder mindestens ein in AI löslicher, thermisch zerfallenden radikalischen Initiator; optional AV mindestens einen elektrisch leitfähigen Röntgenopaker, besonders als ferromagnetische Partikel; eignen sich z.B. zur Herstellung von pastenförmigen Zweikomponenten-Knochenzementen, zur Herstellung von Mitteln zur Fixierung von Totalendoprothesen und Revisionsendoprothesen, zur Herstellung von selbsthärtenden Füllmaterialien für die Vertebroplastie, Kyphoplastie oder Femurhalsaugmentation, oder zur Herstellung von lokalen Wirkstofffreisetzungssystemen, und können bei Anwesenheit der Komponente AV mit magnetischen Wechselfeldern ...

ОТВЕРЖДАЮЩАЯСЯ, СОСТОЯЩАЯ ИЗ ДВУХ ЧАСТЕЙ АКРИЛОВАЯ КОМПОЗИЦИЯ

Данное изобретение относится к отверждающейся, состоящей из двух частей акриловой композиции для костного цемента, стоматологии, связующего или строительного материала. Отверждающаяся, состоящая из двух частей акриловая композиция для костного цемента, стоматологии, связующего, или строительного материала включает первую часть, представляющую собой акриловую полимерную композицию, и вторую часть, представляющую собой акриловую мономерную композицию, причем акриловая полимерная композиция содержит акриловые полимерные частицы первого типа, каждая акриловая полимерная частица первого типа образована сеткой коалесцированных получаемых эмульсионной полимеризацией акриловых микрочастиц. Заявлены варианты композиции, способ получения, клеящее вещество, конструкционный материал, порошковая композиция. Технический результат - получение полимера со значительной долей маленьких частиц с хорошей воспроизводимостью процесса. Это приводит к повышению экономичности процесса. 9 н. и 22 з.п. ф-лы, 10 табл ...

Адгезивная композиция и элемент для прикрепления к коже человека

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2018 103 444 A (51) МПК A61F 5/44 (2006.01) C09J 151/00 (2006.01) A61L 24/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2018103444, 30.01.2018 (71) Заявитель(и): Б. БРАУН МЕДИКАЛ (FR) Приоритет(ы): (30) Конвенционный приоритет: 03.02.2017 FR 17 50958 Адрес для переписки: 119019, Москва, б-р Гоголевский, 11, "Гоулинг ВЛГ (Интернэшнл) Инк.", Костюшенковой Марии Стр.: 1 A 2 0 1 8 1 0 3 4 4 4 R U A (57) Формула изобретения 1. Адгезивная композиция, предназначенная для обеспечения прикрепления к коже человека и содержащая непрерывную фазу и дисперсную фазу гидроколлоидов, причем непрерывная фаза содержит по массе, в расчете на общую массу адгезивной композиции: (i) от 1 до 12 мас. % блок-сополимера стирол-изопрен-стирольного или стиролбутадиен-стирольного типа, (ii) (а) от 1 до 15 мас. % полимера эластомерного бутильного типа, необязательно, в смеси с до 25 мас. % полимера полиизобутиленового типа, или (b) от более чем 10 до 30% полимера полиизобутиленового типа, не содержащего полимер эластомерного бутильного типа, (iii) от 1 до менее чем 10 мас. % полимера этилен-винилацетатного типа, причем в сумме полимеры вышеупомянутых трех типов составляют от 10 до 40%. 2. Композиция по п. 1, в которой по существу отсутствует полярное масло и/или в которой полярная фаза составляет менее чем 10 мас. %. 3. Композиция по п. 1 или 2, в которой непрерывная фаза содержит: (i) от 2 до 8 мас. % блок-сополимера стирол-изопрен-стирольного или стиролбутадиен-стирольного типа, (ii) (а) от 2 до 10 мас. % полимера бутильного эластомерного типа, необязательно в смеси с до 25 мас. % полимера полиизобутиленового типа, (iii) от 2 до менее чем 10% этилен-винилацетатного полимера. 4. Композиция по любому из пп. 1-3, содержащая: (ii) (а) от 2 до 10% полимера бутильного эластомерного типа, не содержащего полимер полиизобутиленового типа. 5. Композиция по любому из пп. 1-3, содержащая: (ii) (а) от 2 ...

Polymerer Zement für die perkutane Vertebroplastie

VERWENDUNG EINER MISCHUNG FÜR DIE HERSTELLUNG VON MEDIZINISCHEN IMPLANTATEN

Bone cement

DUCTILE BONE COMPOSITION FOR FILLING BONE DEFECTS

Foamed skin compatible silicone composition

A skin compatible component attachable to mammalian skin. The component is formed as a foamed silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The foamed skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peristomal skin.

BIOACTIVE MATERIALS, METHODS OF MAKING BIOACTIVE MATERIALS AND METHOD OF USE THEREOF

A bioactive material is made using fibroin solutions and suspensions that can be used alone or as a composite with particles such as core/shell particles. The material is designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The solutions and suspensions can be loaded with core/shell-type particles comprising inorganic core materials that are coated with biodegradable polymers with an outer coating of a calcium phosphate precursor. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The degradation of the particles, when present, can generate additional porosity within the scaffold and release other compounds in a controlled manner to enhance growth and activation of the cells necessary for tissue repair. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues.

EMBOLIC COMPOSITIONS AND METHODS

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

A HARDENABLE TWO PART ACRYLIC COMPOSITION

The invention relates to a hardenable two part acrylic composition, a polymer component of the two part hardenable composition and a method of producing a polymer component of the two part composition. The hardenable two part acrylic composition comprises an acrylic polymer composition first part and an acrylic monomer composition second part. The acrylic polymer composition first part comprises a first type of acrylic polymer particles characterized in that each first type of acrylic polymer particle is formed of a network of coalesced emulsion polymerized acrylic microparticlesor is microporous. The acrylic polymer composition may comprise emulsion polymerised acrylic polymer particles of particle size between 10 and 2000nm.The invention also extends to the use of acrylic polymer particles formed of a network of coalesced emulsion polymerized acrylic microparticles as a dough time reduction agent in a hardenable two part acrylic composition.

TISSUE-ADHESIVE MATERIALS

PANSEMENT ADHESIF ETANCHE

L'INVENTION CONCERNE UN PANSEMENT ADHESIF ETANCHE POUR LA CONFECTION DE PANSEMENTS ISOLANTS SUR LES PARTIES MOBILES (ARTICULATIONS), ET AUTOUR DES ORIFICES, DU CORPS HUMAIN, COMPRENANT UN FILM ELASTIQUE IMPERMEABLE 16 RECOUVERT, DU COTE APPLICABLE A LA PEAU, D'UNE COUCHE DE MATIERE ADHESIVE ELASTIQUE 18, CES DEUX COMPOSANTS SE DEFORMANT RAPIDEMENT ET FACILEMENT ET REVENANT RAPIDEMENT ENSUITE A LEUR FORME ORIGINALE, ET ASSURANT LA PERMANENCE DE LA CAPACITE ADHESIVE DU PANSEMENT MEME EN PRESENCE D'HUMIDITE. LE PANSEMENT EST COMPLETE PAR UNE BANDE PROTECTRICE EXTERNE 10 ENDUITE INTERIEUREMENT DE POLYETHYLENE 14 ET EXTERIEUREMENT DE CIRE DE SILICONE 12 ET, FACULTATIVEMENT, D'UNE BANDE PROTECTRICE INTERNE 20 ENDUITE INTERIEUREMENT DE CIRE DE SILICONE 22, TOUTES DEUX DETACHABLES AVANT USAGE.

ADHESIVE COMPOSITION AND HUMAN SKIN FIXING MEMBER

L'invention a pour objet une composition adhésive destinée à assurer la fixation sur la peau humaine, comprenant une phase continue et une phase discontinue d'hydrocolloïdes,, la phase continue comprenant en poids, sur la base du poids total de la composition adhésive : (i) 1 à 12% en poids d'un polymère séquencé de type styrène-isoprène-styrène ou styrène-butadiène-styrène, (ii) (a) 1 à 15% d'un polymère de type élastomère butyl, éventuellement en mélange avec jusqu'à 25% en poids de d'un polymère de type polyisobutylène, ou (b) plus de 10% à 30% d'un polymère de type polyisobutylène, exempt de polymère de type élastomère butyl, (iii) 1 à moins de 10% d'un polymère de type éthylène vinyl acétate, la somme de ces trois types de polymères représentant de 10 à 40%. The subject of the invention is an adhesive composition intended to ensure attachment to human skin, comprising a continuous phase and a discontinuous phase of hydrocolloids, the continuous phase comprising by weight, based on the total weight of the adhesive composition: (i) 1 to 12% by weight of a block polymer of the styrene-isoprene-styrene or styrene-butadiene-styrene type, (ii) (a) 1 to 15% of a polymer of the butyl elastomer type, optionally as a mixture with up to 25% by weight of a polyisobutylene type polymer, or (b) more than 10% to 30% of a polyisobutylene type polymer, free of butyl elastomer type polymer, (iii) 1 or less 10% of a polymer of ethylene vinyl acetate type, the sum of these three types of polymers representing from 10 to 40%.

COMPOSITE OSSEOUS CEMENT

La présente invention concerne un ciment osseux composite, caractérisé en ce qu'il est constitué par: - une charge minérale pulvérulente bio-compatible (a) assurant la solidité mécanique du ciment; - une charge organique pulvérulente bio-compatible (b) comprenant le mélange d'une part de particules polymères poreuses assurant la pénétration de fluides dans le ciment (b1) et d'autre part de particule polymères biodécomposables destinées à laisser des pores de grand diamètre dans le ciment obtenu afin de créer l'ostéoconductivité (b2); et - un agent liant (c) fait d'une matrice organique Bis GMA et de son activateur.

HEMOSTATIC COMPOSITIONS, ASSEMBLIES, SYSTEMS, AND METHODS EMPLOYING PARTICULATE HEMOSTATIC AGENTS FORMED FROM CHITOSAN AND INCLUDING A POLYMER MESH MATERIAL OF POLY-4-HYDROXY BUTYRATE

A granule or particle made of a chitosan material either carries within it a polymer mesh material of poly-4 -hydroxy butyrate, or has interspersed with it a polymer mesh material of poly-4 -hydroxy butyrate. The granule or particle can be carried within a polymer mesh socklet made of a material consisting essentially of poly-4-hydroxy butyrate. The granule or particle can be used to treat intracavity bleeding.

BONE CEMENT WITH ADAPTED MECHANICAL PROPERTIES

A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.

MUSSEL INSPIRED NANCOMPOSITE ADHESIVES FOR BIOMEDICAL APPLICATIONS

A tissue adhesive composition comprises a biodegradable adhesive; nanoparticles; and a tissue regenerative agent. Methods of adhering tissue comprise applying a film of the tissue adhesive composition to a first surface of a first biological tissue; contacting a second surface of a second biological tissue with the first surface of the first biological tissue, wherein the film of the composition is positioned between and in contact with both the first surface and the second surface.

TISSUE REPAIR AND REPLACEMENT

COMPOSITE BONE CEMENT

ОТВЕРЖДАЮЩАЯСЯ, СОСТОЯЩАЯ ИЗ ДВУХ ЧАСТЕЙ АКРИЛОВАЯ КОМПОЗИЦИЯ

1. Отверждающаяся, состоящая из двух частей акриловая композиция, включающая первую часть, представляющую собой акриловую полимерную композицию, и вторую часть, представляющую собой акриловую мономерную композицию, причем акриловая полимерная композиция содержит акриловые полимерные частицы первого типа, отличающаяся тем, что каждая акриловая полимерная частица первого типа образована сеткой коалесцированных, получаемых эмульсионной полимеризацией акриловых микрочастиц. ! 2. Отверждающаяся, состоящая из двух частей акриловая композиция по п.1, в которой акриловая полимерная композиция также включает акриловые полимерные частицы, по меньшей мере, одного дополнительного типа. ! 3. Отверждающаяся, состоящая из двух частей акриловая композиция по п.2, в которой акриловые полимерные частицы, по меньшей мере, одного дополнительного типа представляют собой полимерные гранулы. ! 4. Отверждающаяся, состоящая из двух частей акриловая композиция по пп.1, 2 или 3, в которой Z-средний размер получаемых эмульсионной полимеризацией микрочастиц составляет менее 2000 нм. ! 5. Отверждающаяся, состоящая из двух частей акриловая композиция по п.4, в которой Z-средний размер получаемых эмульсионной полимеризацией микрочастиц находится в диапазоне 10-2000 нм. ! 6. Отверждающаяся, состоящая из двух частей акриловая композиция по пп.1-3, в которой получаемые эмульсионной полимеризацией микрочастицы представляют собой получаемые в одну стадию или несколько стадий микрочастицы типа ядро/оболочка. ! 7. Отверждающаяся, состоящая из двух частей акриловая композиция по пп.1-3, в которой микрочастицы эмульсии содержат в своей полимерной матриц� РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2011 109 208 (13) A (51) МПК C08F 265/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2011109208/04, 13.08.2009 (71) Заявитель(и): ЛУСАЙТ ИНТЕРНЕЙШНЛ ЮКей ЛИМИТЕД (GB) Приоритет(ы): (30) Конвенционный приоритет: 14.08.2008 GB 0814854.6 06.03.2009 GB 0903912.4 ( ...

POLYMERE CEMENT FOR THE PERCUTANEOUS VERTEBROPLASTIE

FIBROINZUSAMMENSETZUNGEN AND PROCEEDING TO THEIR PRODUCTION

COMPOUND BONE CEMENT

A hardenable two part acrylic composition

Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from chitosan and including a polymer mesh material of poly-4-hydroxy butyrate

Tissue-adhesive materials

A multi-lamellar tissue-adhesive sheet comprises a structural layer or laminate conjoined to a tissue-contacting layer. The structural layer or laminate comprises one or more synthetic polymers having film-forming properties, and the tissue- contacting layer of material contains tissue-reactive groups. The synthetic polymers having film-forming properties are preferably biodegradable polyesters, and the tissue-reactive groups are most preferably NHS-ester groups.

Hemostatic compositions

The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.

Paste-like bone cement

Abstract Paste-like bone cement 5 The present invention provides a kit based on two pastes that is designed to produce bone cement with high initial stability and therefore low post-cure. Said kit comprises a paste A and a paste B, whereby (a) paste A contains (al) a polymer isable monomer with a pH in water in the range of 5 - 9, (a2) a filling agent that is insoluble in (al), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbitu to rates, 1,3,5-trisubstituted barbiturates, and 1,3,5-tetrasubstituted barbiturates, and (b) paste B con tains (b1) a polymerisable monomer with a pH in water in the range of 5 - 9, (b2) a filling agent that is insoluble in (b1), (b3) a peroxide that is soluble in (b1), (b4) a heavy metal compound that is in soluble in (b1) and selected from the consisting of heavy metal salts and heavy metal complexes, whereby at least one of the pastes A and B contains a halide salt.

Paste-like bone cement

Paste-Like Bone Cement The present invention relates to a paste containing at least one polymer for radical 5 polymerisation, at least one polymer that is soluble in said at least one monomer for radical polymerisation, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerisation, whereby the filling agent is a particulate cross-linked polymethacrylate that can be produced through polymerisation of methacrylic acid esters, whereby 10 i)at least 15 % by weight of the methacrylic acid esters used for polymerisation are multi functional methacrylic acid esters, relative to the total weight of the methacrylic acid esters used in the polymerisation, and ii) at least 90 % by weight of the particles of the filling agent, relative to the total weight of the filling agent, have a particle size of no more than 74 tm. 15 The present invention also relates to a kit, the use of a filling agent that is poorly soluble or insoluble in a monomer ...

Bone cement having chemically joined reinforcing fillers

HEMOSTATIC COMPOSITIONS

Abstract The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.

Adhesive for moist tissue and peristomal device made using the same

An adhesive for moist tissue is formulated including a silicone elastomer, a crosslinked polyacrylic acid polymer and a sodium polyacrylate based superabsorbent polymer. The adhesive adheres well to moist tissue, such as a mucosal skin surface. An ostomy skin barrier including a stoma seal made using the adhesive is also disclosed.

HYDROGEL-BASED BIOLOGICAL DELIVERY VEHICLE

A hydrogel-based biological delivery vehicle used to effectively deliver drug and biological material to tissue or organ sites. More specifically, a hydrogel binding matrix having a biopolymer backbone containing carboxyl groups. Tyramine may be substituted for at least a portion of the carboxyl groups, so that, when hydrogen peroxide is added, it causes creation of covalent bonds between tyramine molecules and cross-links the hydrogel binding matrix, thereby enabling the hydrogel binding matrix to transition from liquid to gel state. The hydrogel binding matrix, in its liquid form, is capable of encapsulating drug reservoirs to create a homogenous liquid with evenly distributed particles containing drugs or target molecules. As the hydrogel binding matrix solidifies into a gel state, the newly created cross-links do not disrupt or react with the drugs or target molecules contained within the drug reservoirs. This hydrogel-based biological delivery vehicle can be used in several medical ...

RANDOM AND NON-RANDOM ALKYLENE OXIDE POLYMER ALLOY COMPOSITIONS

A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.

STIMULI-RESPONSIVE MATERIAL AND MEDICAL MATERIAL COMPRISING SAME

A stimuli-responsive material characterized by comprising a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state; and a medical material and an anti-adhesive material, each of which comprises a stimuli-responsive material comprising a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state. A stimuli-responsive material can be provided, which has improved convenience upon application and fulfills all of mechanical characteristics upon being coated and properties required for various use applications (e.g., biodegradability, biocompatibility, low toxicity).

MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES

The invention relates to novel, rapidly hardening adhesives based on hydrophilic polyisocyanate prepolymers for using in surgery for stopping heavy bleeding (haemostasis) and sealing leakages.

HEMOSTATIC SPONGE

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that - said polymeric component is coated onto a surface of said matrix of a biomaterial, or - said matrix is impregnated with said polymeric material, or - both.

HEMOSTATIC SPONGE

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that - said polymeric component is coated onto a surface of said matrix of a biomaterial, or - said matrix is impregnated with said polymeric material, or - both.

MALLEABLE PASTE WITH ALLOGRAFT BONE REINFORCEMENT FOR FILLING BONE DEFECTS

The invention is directed toward a sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a mixture of demineralized osteogenic bone powder with a particle size ranging from about 250 to about 750 microns and surface demineralized cortical bone rods having a diameter ranging from 1.0mm to 5.00mm or larger bone chips. The surface demineralized cortical bone rods have diameter to length ratio ranging from 1:2 to 1:20. The demineralized bone powder range from about 25 to about 30% of the weight of the composition and the cortical bone rods range from 5% to about 10% of the weight of the composition with the carrier being selected from the high molecular weight hydrogel in aqueous solution having a high molecular weight over 700,000 Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution.

TIGHT BAND AID

NON-LIGHT ACTIVATED ADHESIVE COMPOSITE, SYSTEM, AND METHODS

The present invention provides a non-light activated adhesive composite, method, and system suitable for medical and surgical applications. The composite includes a scaffold and a non-light activated adhesive. The scaffold and the non-light activated adhesive include biological, biocompatible, or biodegradable materials.

BONE PASTE

A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-'beta', PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).

Method of Use of Bioactive Materials

A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair.

HEMOSTATIC COMPOSITIONS

The invention relatesto a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.

Composition for in vivo vessel repair

The present invention relates to a biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37 ºC to form a cured material with an elongation until rupture of at least 5 % and an elastic modulus of at least 1 MPa.

SKIN COMPATIBLE ADHESIVE COMPOSITION

УСТРОЙСТВО СБОРА ВЫДЕЛЕНИЙ ОРГАНИЗМА

FIELD: medicine. SUBSTANCE: invention relates to field of medicine and can be used for collection of organism's secretions. Device for collection of organism's secretions contains collection packet and adhesive pad for fixation to skin, and sad pad contains protective layer, first layer and second layer of hydrocolloidal adhesive substance, where second layer of hydrocolloidal adhesive substance, at least, partly is located between first layer of hydrocolloidal adhesive substance and protective layer. First and second layers of adhesive substance consist of continuous and discontinuous phase. Discontinuous phase of first layer of adhesive substance contains pectin, carboxymethylcellulose, gelatin, guar gum and potato starch, continuous phase of first layer of adhesive substance contains polyisobutylene, styrol block-copolymer, butyl rubber and tackifier. Discontinuous phase of second layer of adhesive substance contains carboxymethylcellulose, gelatin and guar gum, and continuous phase of second layer of adhesive substance contains polyisobutylene and styrol block-copolymer. EFFECT: invention improves indices of tack and adhesiveness of first layer, which makes it possible to prevent passage of liquid, secreted fro body orifice through adhesive construction with preservation of low risk of irritation of skin around patient's body orifice. 11 cl, 3 dwg, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 535 118 C2 (51) МПК A61F 5/44 (2006.01) A61L 15/58 (2006.01) A61L 24/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012125825/15, 26.11.2010 (24) Дата начала отсчета срока действия патента: 26.11.2010 (72) Автор(ы): СИОК Данута (DK) (73) Патентообладатель(и): КОЛОПЛАСТ А/С (DK) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 20.01.2014 Бюл. № 2 R U 27.11.2009 DK PA200970233 (45) Опубликовано: 10.12.2014 Бюл. № 34 01/05340 A2, 25.01.2001. WO 2007/076862 A1, 12.07. ...

Patent RU2018103444A3

7 ВУ“? 2018103444” АЗ Дата публикации: 14.05.2021 Форма № 18 ИЗПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение ж 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2018103444/04(005003) 30.01.2018 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 1750958 03.02.2017 ЕК Название изобретения (полезной модели): [Х] - как заявлено; [ ] - угочненное (см. Примечания) Адгезивная композиция и элемент для прикрепления к коже человека Заявитель: Б. БРАУН МЕДИКАЛ, ЕК 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) Аб1Е 5/44 (2006.01) Аб, 15/58 (2006.01) В32В 27/30 (2006.01) Аб1Т. 24/00 (2006.01) (09.1 151/00 (2006.01) В32В 27/32 (2006.01) Аб. 24/04 (2006.01) В32В 27/00 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) Аб1Е5/44; Аб1124/00; Аб11.24/04; Аб11Т.15/58; С091151/00; В32В27/00; В32В27/30; В32В27/32 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): ЕАРАТТУ, Е$расепе, Соозе, боое Раеп$, Рабеагсв, ...

ЧУВСТВИТЕЛЬНЫЙ К СТИМУЛАМ МАТЕРИАЛ И МЕДИЦИНСКИЙ МАТЕРИАЛ, СОДЕРЖАЩИЙ ЕГО

1. Чувствительный к стимулам материал, который отличается тем, что содержит чувствительный к стимулам полимер, волокна и воду, где волокна диспергируют в качестве имеющих среднечисловой диаметр от 1 до 900 нм.2. Чувствительный к стимулам материал по п. 1, где массовое отношение (чувствительный к стимулам полимер/волокно) чувствительного к стимулам полимера к волокну составляет от 5 до 100.3. Чувствительный к стимулам материал по п. 1, где чувствительный к стимулам полимер представляет собой чувствительный к температуре полимер, который имеет нижнюю критическую температуру растворения.4. Чувствительный к стимулам материал по п. 1, где разность параметров растворимости основной химической структуры чувствительного к стимулам полимера и волокна составляет 0 до 5.5. Чувствительный к стимулам материал по п. 1, где чувствительный к стимулам полимер и волокно имеют общую основную химическую структуру, выбранную из амидного звена, звена гидроксикислоты и моносахаридного звена.6. Чувствительный к стимулам материал по п. 1, где чувствительный к стимулам полимер представляет собой полимер на основе поли(N-изопропилакриламида) и волокно представляет собой волокно на основе полиамида.7. Чувствительный к стимулам материал по п. 1, где чувствительный к стимулам полимер содержит молочнокислое звено и волокно представляет собой полимолочную кислоту.8. Чувствительный к стимулам материал по п. 1, где волокно имеет длину волокна от 0,01 до 10,0 мм.9. Чувствительный к стимулам материал по п. 1, где отношение (L/D) длины волокна к диаметру волокна составляет 200 до 100000.10. Чувствительный к стимулам материал по п. 1, который дополнительно содержит поверхностно-активное вещество, которое имеет среднечислов РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61K 9/70 A61K 47/30 B82Y 5/00 A61P 41/00 (13) 2014 136 336 A (2006.01) (2006.01) (2011.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2014136336, 29.01.2013 (71) Заявитель(и): ...

Einkomponenten-Knochenzementpasten, deren Verwendung und Verfahren zu deren Aushärtung

Einkomponenten PMMA-Knochenzementpaste enthaltend AI mindestens ein radikalisch polymerisierbares Methacrylatmonomer, AII mindestens ein in AI lösliches Polymer und AIII mindestens ein in AI nicht lösliches partikuläres Polymer mit einer Partikelgröße kleiner 500 m.

Kit zur Herstellung von Knochenzement und Verwendung dieses Kits

Kit zur Herstellung von Knochenzement, aufweisend eine Paste A und eine Paste B, wobei (a) Paste A (a1) ein polymerisierbares Monomer mit einem pH-Wert in Wasser im Bereich von 59, (a2) einen in (a1) unlöslichen Füllstoff und (a3) ein Barbitursäurederivat, das aus der Gruppe ausgewählt ist, die aus 1,5-disubstituierten Barbituraten, 1,3,5-trisubtituierten Barbituraten und 1,3,5-tetrasubtituierten Barbituraten besteht, enthält, und (b) Paste B (b1) ein polymerisierbares Monomer mit einem pH-Wert in Wasser im Bereich von 59, (b2) einen in (b1) unlöslichen Füllstoff, (b3) ein in (b1) lösliches Peroxid, (b4) eine in (b1) unlösliche Schwermetallverbindung, die aus der Gruppe ausgewählt ist, die aus Schwermetallsalzen und Schwermetallkomplexen besteht, enthält, wobei in wenigstens einer der Pasten A und B ein Halogenidsalz enthalten ist.

Skin compatible silicone composition

A bone cement

POROUS BONE SUBSTITUTES

DUCTILE PASTE FOR FILLING BONE DEFECTS

ADHESIVE MASS WITH SPHERICAL MICRO COLLOID PARTICLES

DUCTILE HYDRAULICCOLLOIDAL ADHESIVE COMPOSITION

DENTALWERKSTOFF

Embolic compositions and methods

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other ...

Methods and articles for fusing matrix layers containing non-collagenous proteins to tissue

HOT-MELT SILICONE BASED OSTOMY AND WOUND CARE SKIN ATTACHMENT ADHESIVES

An ostomy or wound care appliance including an ostomy or wound care device for attachment to the body with an adhesive. The adhesive including a hot- melt silicone pressure sensitive adhesive composition and a reinforcing member.

PASTE-LIKE BONE CEMENT

The present invention provides a kit based on two pastes that is designed to produce bone cement with high initial stability and therefore low post-cure. Said kit comprises a paste A and a paste B, whereby (a) paste A contains (a1) a polymerisable monomer with a pH in water in the range of 5 - 9, (a2) a filling agent that is insoluble in (a1), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbiturates, 1,3,5-trisubstituted barbiturates, and 1,3,5- tetrasubstituted barbiturates, and (b) paste B contains (b1) a polymerisable monomer with a pH in water in the range of 5 - 9, (b2) a filling agent that is insoluble in (b1), (b3) a peroxide that is soluble in (b1), (b4) a heavy metal compound that is insoluble in (b1) and selected from the consisting of heavy metal salts and heavy metal complexes, whereby at least one of the pastes A and B contains a halide salt.

TWO-PHASE COMPOSITES OF IONICALLY-CONDUCTIVE PRESSURE-SENSITIVE ADHESIVE; BIOMEDICAL ELECTRODES

... 2115441 9309713 PCTABS00022 A two-phase composite of ionically-conductive pressure-sensitive adhesive (14, 36), biomedical electrodes (10, 30) using the composite and methods of preparing the composite and the electrode are disclosed. The continuous phase is a hydrophilic, solid state pressure-sensitive adhesive composition ionically-conductive regardless of an amount of water present in the composition. The discontinuous phase are domains of a hydrophilic pressure-sensitive adhesive which enhances adhesion of the composite to mammalian skin while maintaining acceptable alternating current impedance of the composite.

Stimuli-responsive material and medical material comprising same

A stimuli-responsive material characterized by comprising a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state; and a medical material and an adhesion-preventing material, each of which comprises a stimuli-responsive material comprising a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state. A stimuli-responsive material can be provided, which has improved convenience upon application and fulfills all of dynamic properties upon being coated and properties required for various use applications (e.g., biodegradability, biocompatibility, low toxicity).

Bioactive materials, methods of making bioactive materials and method of use thereof

MATERIALS IN THE FORM OF NETWORKS INTERPENETRATE POLYMERS ASSOCIATING A FIBRIN GEL AND A POLYETHYLENE GLYCOL NETWORK

La présente invention se rapporte à un procédé de préparation d'un matériau sous forme de réseau interpénétré de polymères (RIP) associant un gel physique de fibrine et un réseau de polyéthylène (PEG). Elle se rapporte également aux matériaux susceptibles d'être obtenus par ce procédé ainsi que leur utilisation comme pansement pour les plaies, pansement chirurgical, comme un dispositif pour livrer des agents thérapeutiques, comme revêtement pour des dispositifs médicaux comme par exemple des stents, valves pour le coeur, des cathéters, des filtres prosthétiques vasculaires etc. Lesdits matériaux peuvent également être utilisés pour des cultures de cellules eucaryotes, ou encore comme support de molécules actives comme les antibiotiques ou les enzymes.

POLYMERIC CEMENT FOR THE PERCUTANEOUS VERTEBROPLASTIE

La présente invention a pour objet un ciment fluide à usage médical pour la reconstruction osseuse, notamment pour le comblement du corps vertébral, ainsi qu'une composition binaire destinée à la préparation d'un tel ciment. Un autre objet de la présente invention est un dispositif de conditionnement de ladite composition binaire. Un procédé de préparation d'un ciment osseux à partir d'une composition binaire est également revendiqué. Le ciment fluide selon l'invention comprend : a) environ 70% à 85 % en poids d'un polymère comprenant un polyméthylméthacrylate et un méthylméthacrylate monomère, et b) environ de 15 % à 30 % en poids d'une composition radio-opaque. De préférence, la composition radio-opaque comprend un radio-opacifiant tel que le sulfate de barium et le dioxyde de zirconium, en mélange avec un phosphate de calcium, par exemple l'hydroxyde d'apatite.

MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES

DENTAL/SURGICAL SEALANTS INCLUDING SHAPEABLE PARTICLES

A sealant composition, suitable for surgical or dental use, comprises a sealant and, dispersed therein, one or more particles of a material which is prestressed and/or capable of undergoing expansion or contraction.

COMPOSITE BONE CEMENT

The invention relates to an absorbable, conformable composite preform comprising an absorbable mixture of oppositely charged, solid microparticulate polyeletrolytes encased in a sealed flexible, absorbable copolyester fabric construct, wherein the said preform undergoes solidification into a single mass having a modulus of more than 0.5 GPa upon contacting an aqueous medium.

Hemorrhage management system

An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein.

SILICONE ABSORBENT ADHESIVE LAYER

STIMULI-RESPONSIVE MATERIAL AND MEDICAL MATERIAL COMPRISING SAME

A stimuli-responsive material characterized by comprising a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state; and a medical material and an anti-adhesive material, each of which comprises a stimuli-responsive material comprising a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state. A stimuli-responsive material can be provided, which has improved convenience upon application and fulfills all of mechanical characteristics upon being coated and properties required for various use applications (e.g., biodegradability, biocompatibility, low toxicity).

Absorbable adhesive paste

An absorbable adhesive paste contains absorbable solid carboxy-bearing microparticles dispersed in a continuous phase of an alkoxyalkyl cyanoacrylate. The paste may contain a soluble absorbable polymeric viscosity modifier and at least one bioactive agent to maximize the effective application as a cover for compromised tissues and wounds or as sealants, blocking agents, or hemostatic agents.

Porous vascular closure plug with starch powder

The disclosure provides a composite plug for vascular closure including a hemostatic material, and a method of manufacturing the composite plug including a hemostatic material. The composite plug may comprise one or more materials having varying porosity, density, or composition, and may include a powdered hemostatic material.

Reinforced surgical adhesives and sealants and their in-situ application

In situ application of reinforced adhesive: applying uncured and curable matter to a surface, applying biocompatible inert reinforcing agent comprising at least one curing agent to the uncured composition; allowing curing within subject, cured composition together with the added reinforcing agent being configured to have improved mechanical support and strength.

Hemostatic sponge

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that—said polymeric component is coated onto a surface of said matrix of a biomaterial, or—said matrix is impregnated with said polymeric material, or—both.

SILK FIBROIN AND POLYETHYLENE GLYCOL-BASED BIOMATERIALS

This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and maleimides functionalized PEGs) that are additionally stabilized by the beta-sheet formation of silk fibroin. The crosslinked silk-PEGs biomaterials present strong adhesive properties, which are comparable to or better than the current leading PEG-based sealant, depending on the silk concentration in the silk-PEGs biomaterials. In addition, the silk-PEGs based biomaterials are cytocompatible, show decreased swelling behavior and longer degradation times, which make them suitable for hemostatic applications where the current available tissue sealant products can be contraindicated. 1. A method of preparing a crosslinked polymer matrix , comprising:admixing a composition comprisingat least two functionally activated PEG components capable of reacting with one another to form a crosslinked matrix, andsilk fibroin, wherein beta sheet formation of the silk fibroin further stabilizes the crosslinked matrix.2. The method of claim 1 , wherein the silk fibroin is at a concentration of at least about 10 wt %.3. The method of claim 1 , further comprising exposing the mixture to an alcohol treatment or a water-annealing treatment.4. The method of claim 1 , wherein the silk fibroin is depleted of sericin before admixing with the functionally activated PEG components.5. The method of claim 1 , wherein the crosslinked matrix is a hydrogel claim 1 , a mat claim 1 , a film claim 1 , a sponge claim 1 , a 3-dimensional scaffold claim 1 , a fiber or any combinations thereof.6. The method of claim 1 , wherein each PEG component is a four-armed PEG.7. The method of claim 1 , wherein one of the PEG components is functionally activated with a maleimidyl group.8. The method of claim 7 , wherein one of the PEG components is functionally activated with a thiol ...

System for use in bone cement preparation and delivery

A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.

MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES

The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) 110.-. (canceled)12. The formulation according to claim 11 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas.13. The formulation according to claim 12 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the organic fillers.14. The formulation according to claim 11 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester.15. The formulation according to claim 14 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with organic fillers.16. The formulation according to claim 11 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas and wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester and the organic fillers.17. The formulation according to claim 11 , wherein the polyol component has a number-average molecular weight of 4000 to 8500 g/mol.18. The formulation according to claim 11 , wherein the polyol component comprises a polyalkylene oxide polyether.19. The formulation according to claim 18 , wherein the polyalkylene oxide polyether contain from 60% to 90% of ethylene oxide-based units claim 18 , based on the total amount of alkylene oxide units.20. The formulation according to claim 12 , wherein the organic fillers comprise polyether polyols.21. The formulation according to claim 11 , wherein the formulation is cured for a period of time from 30 seconds to 10 ...

HEMOSTATIC SPONGE

The present invention provides a hemostatic porous composite sponge comprising: 1. A method of manufacturing a hemostatic composite , comprising:contacting a sponge comprising a matrix of a biomaterial in dried form with a reactive polymeric material in the form of a solution so that the biomaterial is impregnated with the reactive polymeric material or the reactive polymeric material is coated onto a surface of the matrix of the biomaterial, or both; anddrying the contacted biomaterial and reactive polymeric material.2. A hemostatic composite comprising a sponge comprising a matrix of a biomaterial that is impregnated with a reactive polymeric material obtained by the method of .3. A hemostatic composite comprising a sponge comprising a matrix of a biomaterial that is coated with a reactive polymeric material obtained by the method of .4. The method of claim 1 , wherein the reactive polymeric material is a reactive hydrophilic polymeric material.5. The method of claim 1 , wherein the reactive polymeric material is a single reactive hydrophilic polymeric material.6. The method of claim 1 , wherein the reactive polymeric material is a single hydrophilic polymeric material comprising electrophilic reactive groups claim 1 , wherein the hydrophilic polymeric material is a hydrophilic crosslinker.7. The method of claim 1 , wherein the reactive polymeric material comprises a polyethylene glycol (PEG).8. The method of claim 1 , wherein the reactive polymeric material comprises a polyethylene glycol (PEG) comprising two or more reactive groups selected from the group consisting of succinimidyl esters (—CON(COCH)) claim 1 , aldehydes (—CHO) claim 1 , and isocyanates (—N═C═O).9. The method of claim 1 , wherein the biomaterial is impregnated with the reactive polymeric material.10. The method of claim 1 , wherein the reactive polymeric material is coated onto a surface of the matrix of the biomaterial. This application is a divisional of U.S. patent application Ser. No. 14/184 ...

Adhesive Properties

Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.

MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES

The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) 110.-. (canceled)12. The formulation according to claim 11 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas.13. The formulation according to claim 12 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the organic fillers.14. The formulation according to claim 11 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester.15. The formulation according to claim 14 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with organic fillers.16. The formulation according to claim 11 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas and wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester and the organic fillers.17. The formulation according to claim 11 , wherein the polyol component has a number-average molecular weight of 4000 to 8500 g/mol.18. The formulation according to claim 11 , wherein the polyol component comprises a polyalkylene oxide polyether.19. The formulation according to claim 18 , wherein the polyalkylene oxide polyether contains from 60% to 90% of ethylene oxide-based units claim 18 , based on the total amount of alkylene oxide units.20. The formulation according to claim 12 , wherein the organic fillers comprise polyether polyols.21. The formulation according to claim 11 , wherein the formulation is curable for a period of time from 30 seconds to 10 ...

BONE TREATMENT SYSTEMS AND METHODS

The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition. 1. A bone cement composition configured to provide a controlled viscosity , comprising:a liquid component comprising a monomer; anda non-liquid component comprising first polymer beads having a first average cross-sectional dimension and comprising a radical initiator at a first amount, and second polymer beads having a second average cross-sectional dimension greater than the first average cross-sectional dimension and comprising the radical initiator at a second amount lower than the first amount.2. The bone cement composition of claim 1 , wherein the initiator is dispersed throughout each of the first polymer beads and the second polymer beads.3. The bone cement composition of claim 1 , wherein the first average cross-sectional dimension is less than 100 microns claim 1 , and the second average cross-sectional dimension is greater than 100 microns.4. The bone cement composition of claim 1 , wherein the first polymer beads and the second polymer beads comprise polymethyl methacrylate polymer (PMMA).5. The bone cement composition of claim 4 , wherein the non-liquid component comprises less than 75 wt % PMMA on the basis of a total weight of the non-liquid component.6. The bone cement composition of claim 1 , wherein the radical initiator comprises benzoyl peroxide (BPO).7. The bone cement composition of claim 6 , wherein the ...

ADHESIVE FOR MOIST TISSUE AND PERISTOMAL DEVICE MADE USING THE SAME

An adhesive for moist tissue is formulated including a silicone elastomer, a crosslinked polyacrylic acid polymer and a sodium polyacrylate based superabsorbent polymer. The adhesive adheres well to moist tissue, such as a mucosal skin surface. An ostomy skin barrier including a stoma seal made using the adhesive is also disclosed. 1. An adhesive composition for moist tissue comprising:about 80 wt. % to about 98 wt. % of a two-part addition curing silicone composition; andabout 2 wt. % to about 20 wt. % of at least one hydrophilic component;wherein the adhesive composition is cured to form a viscoelastic adhesive that adheres to a moist mucocutaneous tissue and a mucosal tissue.2. The adhesive composition of claim 1 , wherein the at least one hydrophilic component comprises a crosslinked polyacrylic acid polymer.3. The adhesive composition of claim 1 , wherein the hydrophilic component comprises a sodium polyacrylate based superabsorbent polymer.4. The adhesive composition of claim 1 , wherein the two-part addition curing silicone composition comprises a component A including a platinum catalyst and vinyl functional polymers (R—CH═CH) and a component B comprising silicone hydride groups (—SiH).5. The adhesive composition of claim 1 , wherein the viscoelastic adhesive has a total work adhesion greater than about 7 N·mm and an elongation before detaching greater than about 3.0 mm and less than about 150 mm when tested according the Spherical Probe Tack and Adhesion test method described in Examples and Test Results section of the present disclosure.6. The adhesive composition of claim 1 , wherein the viscoelastic adhesive has a total work adhesion greater than about 100 g·mm and an elongation before detaching greater than about 5.0 mm and less than about 50 mm when tested according the Moist Tissue Tack and Adhesion test method described in Examples and Test Results section of the present disclosure.7. The adhesive composition of claim 1 , wherein the viscoelastic ...

Composites and devices for interfacing electronics to biological tissue

Composites, are provided, the composites comprising: mixed conducting particles; and an ion conducting scaffolding matrix. In some embodiments, the mixed conducting particles are made from poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate). In some embodiments, the ion conducting scaffolding matrix includes a chitosan (CS)-based polymer. In some embodiments, devices are provided, the devices comprising: a composite comprising mixed conducting particles and an ion conducting scaffolding matrix; and three electrodes, wherein: each of the three electrodes is in contact with the composite; a first pair of the three electrodes are on opposite sides of the composite and are a distance h apart; a second pair of the three electrodes are on a same side of the composite and are a distance d1 apart; a particle size of the mixed conducting particles is between h and d1; a mean-free-path of the mixed conducting particles is less than d1; and the composite behaves like an anisotropic conductor.

BONE CEMENT COMPOSITION KIT

The present invention provides a bone cement composition kit. The bone cement composition kit includes a bone matrix component and a hydrogel component, respectively stored in separate containers, wherein the bone matrix component includes a bone matrix, the hydrogel component includes an acrylic polymer and an acrylic monomer. A ratio of the bone matrix component to the hydrogel component is in a range from about 1:2 (mL/mL) to about 1:50 (mL/mL). 1. A bone cement composition kit , comprising a bone matrix component and a hydrogel component , respectively stored in separate containers , wherein the bone matrix component comprises a bone matrix , the hydrogel component comprises an acrylic polymer and an acrylic monomer , and the ratio of the bone matrix component to the hydrogel component is in a range from about 1:2 (ml/ml) to 1:50 (ml/ml).2. The bone cement composition kit of claim 1 , wherein the bone matrix component further comprises a vehicle claim 1 , wherein the vehicle is selected from the group consisting of cellulose claim 1 , cellulose derivatives claim 1 , glycerol claim 1 , polyethylene glycol (PEG) claim 1 , glycosaminoglycan claim 1 , collagen claim 1 , gelatin claim 1 , ethylene glycol claim 1 , propylene glycol claim 1 , polyhydroxyalkanoate (PHA) claim 1 , polylactic acid (PLA) claim 1 , polyglycolic acid (PGA) claim 1 , poly(lactic-co-glycolic acid) (PLGA) claim 1 , polycaprolactone (PCL) claim 1 , and a mixture thereof.3. The bone cement composition kit of claim 2 , wherein the cellulose derivatives is selected from the group consisting of methyl cellulose claim 2 , sodium carboxymethyl cellulose claim 2 , carboxymethyl cellulose (CMC) claim 2 , hydroxyethyl cellulose (HEC) claim 2 , ethyl cellulose claim 2 , hydroxypropyl cellulose (HPC) claim 2 , hydroxypropyl methyl cellulose (HPMC) claim 2 , and a mixture thereof; the polyethylene glycol (PEG) is selected from the group consisting of polyethylene glycol 600 (PEG600) claim 2 , polyethylene ...

SKIN COMPATIBLE COMPOSITION

A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-skin. 1. A skin compatible component attachable to mammalian skin comprising:a silicone polymer network derived from the addition curing of a first part including a vinyl functionalised siloxane polymer and a second part including a silicon hydride containing crosslinker, in the presence of a metal catalyst; anda superabsorbent particulate distributed within the polymer network configured to absorb moisture from the skin;wherein the superabsorbent particulate has an average particle size less than 150 μm.2. The component as claimed in wherein the superabsorbent particulate comprises an average particle size in the range 10 to 40 μm claim 1 , 15 to 35 μm or 20 to 30 μm.3. The component as claimed in wherein the superabsorbent particulate is distributed within the polymer network at a concentration in the range 5 to 45 wt % claim 1 , 10 to 40 wt % claim 1 , 15 to 35 wt % or 20 to 30 wt %.4. The component as claimed in wherein the superabsorbent particulate comprises any one or a combination of the set of:a naturally occurring hydrocolloid;a semi-synthetic hydrocolloid; ora synthetic hydrocolloid.5. The component as claimed in wherein the superabsorbent particulate comprises any one or a combination of:a polysaccharide;a cellulose;hydroxyethylcellulose;carboxymethylcellulose;hydroxypropylcellulose.6. The component as claimed in wherein the superabsorbent particulate comprises any one or a combination of:carboxymethyl β-glucan;cross-linked sodium carboxymethyl cellulose;sodium carboxymethyl cellulose; ormethylcellulose.7. The component as claimed in ...

METHOD FOR PREPARING A TISSUE-ADHESIVE SHEET

The invention provides a method for preparing tissue-adhesive sheets that may suitably be applied as an implantable haemostatic or sealing construct during surgical procedures, said method comprising:

Fibrin Sealant Compositions with Chemical Crosslinking

The invention relates to tissue adhesives or sealants, more specifically to fibrinogen based sealants reinforced with particulate material and chemically cross-linked. More particularly, the present invention is directed to tissue sealant, adhesive, hemostat, or scaffolding material containing thrombin, fibrinogen, a biocompatible particulate material having amine functionality, and a biocompatible polymer containing aldehyde groups. The present invention is also directed to methods for the use of such materials.

Body fluid resistant tissue adhesives

A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.

HYDROPHOBIC ADHESIVE WITH ABSORBENT FIBERS

The disclosed hydrophobic adhesive composition comprises a hydrophobic adhesive matrix and water absorbent fibers dispersed throughout the adhesive matrix to provide water management capabilities to the adhesive composition. The disclosed adhesive composition can adhered to a variety of surfaces, such as skin, and will easily remove from the surface. Therefore, the disclosed adhesive is particularly well suitable for application to skin wherein the absorbent fiber can absorb perspiration, water, or wound fluid from skin. 117-. (canceled)18. An adhesive composition comprising:a radiation crosslinked hydrophobic adhesive; anda plurality of water absorbent fibers dispersed throughout the hydrophobic adhesive, wherein at least a portion of the fibers are exposed at an outer surface of the adhesive composition and at least a portion of the fibers contact one another at mutual points of contact.191. The adhesive composition of claim , wherein the hydrophobic adhesive is a hydrophobic silicone.20. The adhesive composition of claim 19 , wherein the silicone comprises a crosslinked poly diorganosiloxane.21. The adhesive composition of claim 20 , wherein poly diorganosiloxane material comprises a poly dimethylsiloxane.22. The adhesive composition of claim 21 , wherein the poly dimethylsiloxane is selected from the group consisting of one or more silanol terminated poly dimethylsiloxanes claim 21 , one or more non-functional poly dimethylsiloxanes claim 21 , and combinations thereof.23. The adhesive composition of claim 22 , wherein the poly dimethylsiloxane consists of one or more non-functional poly dimethylsiloxanes.241. The adhesive composition of claim claim 22 , wherein the adhesive further comprises a silicate resin tackifier.251. The adhesive composition of claim claim 22 , wherein the adhesive further comprises a poly(dimethylsiloxane-oxamide) linear copolymer.261. The adhesive composition of claim claim 22 , wherein the absorbent fiber comprises a natural hydrophilic ...

Treatment of Urinary Incontinence with Regenerative Glue

The invention relates to methods for the treatment of urinary incontinence (UI) and stress urinary incontinence (SUI) in both men and women by replacement of a damaged, absent or injured pubo-urethral ligament (PUL) via a simple injection of “Regenerative Glue.” For example, in the case of UI, the injection of “Regenerative Glue” at the PUL site will adhere the ventral surface of the urethra to the dorsal surface of the symphysis pubis (i.e. the space of Retzius), and further provide regenerative material for continuous replacement of deficient tissues and cells. “The Regenerative Glue” can be made from several commercially available materials including biocompatible glues, fibrin sealant or biocompatible gels; combined with Meschencymal stem cells (MSC) derived from bone marrow or adipose tissues. 1. A method , comprising: i) a subject exhibiting at least one symptom of urinary incontinence due to pubo-urethral ligament damage;', 'ii) a composition comprising at least one fibrin glue and an amount of meschencymal stem cells;, 'a) providingb) contacting said composition with said pubo-urethral ligament damage; andc) reducing said at least one symptom of urinary incontinence.2. The method according to claim 1 , wherein said fibrin glue comprises elements selected from the group consisting of fibrinogen claim 1 , collagen claim 1 , collagen hydrogels claim 1 , and tyramine substituted enzymatically cross-linkable collagen gels.3. The method according to claim 1 , wherein said meschencymal stem cells are size-sieved stem cells (SSCs) with a diameter equal or greater than 3-μm.4. The method according to claim 1 , wherein said contacting is topical.5. The method according to claim 1 , wherein said reducing said at least one symptom enhances claim 1 , at least partially claim 1 , a functional recovery from urinary incontinence.6. The method according to claim 1 , wherein said reducing said at least one symptom improves urine retention.7. The method according to claim 1 , ...

SYSTEM FOR USE IN BONE CEMENT PREPARATION AND DELIVERY

A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement. 120-. (canceled)21. A method of preparing a bone cement , comprising:forming a mixture of a monomer liquid and polymer beads in a chamber having an opening at one end and a porous member at another end;applying a pressure to the mixture; anddetermining a level of mixing between the monomer liquid and the polymer beads based on a level of saturation of the porous member by the monomer liquid.22. The method of claim 21 , wherein determining the level of mixing comprises determining that the mixture has been adequately mixed based on detecting that the porous member is saturated with the monomer liquid that has been in contact with the polymer beads such that no further mixing is to be performed prior to injecting the mixture into a patient.23. The method of claim 22 , wherein the porous member is configured to pass air therethrough and to selectively prevent the monomer liquid that has been in contact with the polymer beads and having a viscosity greater than a predetermined value from passing therethrough.24. The method of claim 23 , wherein applying the pressure comprises using a pressure applicator to remove air from the mixture through the porous member while preventing the contacted monomer liquid from passing through the porous member.25. The method of claim 23 , wherein the polymer beads and the monomer liquid are configured such that the monomer liquid attains a viscosity exceeding ...

SILICONE ADHESIVES TO SECURE MEDICAL APPLIANCES TO MAMMALIAN BODY

The present disclosure relates to the field of skin friendly silicone adhesive compositions and use of such compositions to secure medical appliances to mammalian body, and to protect and treat peri-skin surface. 1. A method of forming a cured silicone adhesive composition to protect a region of a skin surface or peri-skin of a mammalian body , comprising the steps of a) mixing adhesive components comprising:i. 50-90 wt % of uncured silicone gel adhesive comprising a blend of a polyorganosiloxane with at least one aliphatically unsaturated group, a organosiloxane with at least one silicone-hydride group, and an addition curing catalyst;ii. 1-50 wt % of a non-silicone hydrophilic liquid additive;iii. 0.1-10 wt % of a cohesive strengthening agent; andb) coating the above adhesive mixture on a surface; andc) curing the coated adhesive mixture to form the cured adhesive composition on the surface.2. The method as claimed in wherein the adhesive composition has a peel adhesion of 0.20-3.9 N/cm (0.5-10 N/in) claim 1 , 0.39-3.15 N/cm (1-8 N/in) claim 1 , 0.79-2.36 N/cm (2-6 N/in) claim 1 , 1.2-2.0 N/cm (3-5 N/in) or the like.3. The method as claimed in wherein the adhesive composition has a tack of 50-2000 grams claim 1 , 100-1500 grams claim 1 , 200-1000 grams claim 1 , 300-500 grams claim 1 , or the like.4. The method as claimed in wherein the hydrophilic liquid additive is included in the range 1%-50% claim 1 , 5-40% claim 1 , 10-30% or 15-20% by weight of the total adhesive composition.5. The method as claimed in wherein the hydrophilic liquid additive comprises any one or a combination of the group comprising: hydroxy acids claim 1 , polyethylene glycol claim 1 , polyethylene glycol-polypropylene glycol copolymers claim 1 , glycerol ethoxylate claim 1 , triacetin claim 1 , hyaluronic acid and its derivatives claim 1 , sodium hyaluronate claim 1 , propylene glycol claim 1 , polyglycerol claim 1 , glycerol and its esters claim 1 , sodium pyroglumatic acid claim 1 , ...

Malleable controlled release local anesthetic with hemostatic composition

A malleable sustained release formulation is created utilizing a local anesthetic wherein the composition is made sustained release by incorporating it into a bovine or porcine hemostatic agent. The composition is malleable enough to fit into a cavity such as a dental cavity and form the shape of the cavity. In addition to providing sustained release of the anesthetic, the composition also provides quicker reduction in bleeding.

Flexible Gelatin Sealant Dressing with Reactive Components

The present invention is directed to hemostatic sealants having a compressed porous substrate, an electrophilic group containing component that is not gelatin or collagen, a nucleophilic group containing component, and a buffering agent. The present invention also relates to method for manufacture and use of such sealants to seal and/or achieve hemostasis. 1. A hemostatic sealant comprising: a) compressed porous substrate; b) an electrophilic group containing component that is not gelatin or collagen; c) a nucleophilic group containing component; and d) a buffering agent.2. A hemostatic sealant according to wherein the compressed porous substrate is a layer of collagen or gelatin.3. A hemostatic sealant according to claim 2 , wherein the gelatin is crosslinked.4. A hemostatic sealant according to wherein the gelatin has a thickness of less than 5 millimeters.5. A hemostatic sealant according to claim 2 , wherein the gelatin has a thickness of 2 millimeters or less.6. A hemostatic sealant according to wherein the gelatin has an open cell porous structure throughout the layer.7. A hemostatic sealant according to wherein the electrophilic component is a polymeric compound derived from a polyethylene glycol having at least two electrophilic groups.8. A hemostatic sealant according to wherein the electrophilic groups are selected from the group consisting of succinimides claim 7 , succinimidyl glutarate claim 7 , carboxymethyl-hydroxybutyrate-N-hydroxysuccinimide claim 7 , carbonyldiimidazole claim 7 , sulfonyl chloride claim 7 , aryl halides claim 7 , sulfosuccinimide ester claim 7 , epoxide claim 7 , aldehyde claim 7 , maleimides and imidoester and combinations thereof.9. A hemostatic sealant according to wherein the nucleophilic group containing component is a polymeric material derived from polyethylene glycol having at least two nucleophilic groups.10. A hemostatic sealant according to wherein the nucleophilic groups are selected from the group consisting of ...

Tissue-Adhesive Material

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend. 117.-. (canceled)18. A tissue-adhesive device for sealing dura mater comprising a multilayered structure having at least a first layer and a second layer ,the first layer comprising a foam structure including a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer, wherein the synthetic tissue-reactive polymer comprises a multi-arm polyethylene glycol functionalized with at least one tissue-reactive group that comprises an activated ester, andthe second layer comprising a sheet structure.19. The tissue-adhesive device of claim 18 , having an adhesive strength of more than 1 N.20. The tissue-adhesive device of claim 18 , having a burst-resistance of at least 8 mmHg.21. The tissue-adhesive device of claim 18 , having a burst-resistance of at least 15 mmHg.22. The tissue-adhesive device of claim 18 , having a burst-resistance of at least 30 mmHg.23. The tissue-adhesive device of claim 18 , having a burst-resistance of at least 45 mmHg.24. The tissue-adhesive device of claim 18 , wherein the carrier polymer is a synthetic carrier polymer and comprises one or more of a polyester claim 18 , polyether claim 18 , polyhydroxyacid claim 18 , polylactone claim 18 , polyetherester claim 18 , polycarbonate claim 18 , polydioxane claim 18 , polyanhydride claim 18 , polyurethane claim 18 , polyester(ether)urethane claim 18 , polyurethane urea claim 18 , polyamide claim 18 , polyesteramide claim 18 , poly-orthoester claim 18 , polyaminoacid claim 18 , polyphosphonate claim 18 , polyphosphazene.25. The tissue-adhesive device of claim 24 , wherein the synthetic carrier polymer comprises a poly(DL-lactide-co-ε-caprolactone) copolymer obtainable by the ...

FILM, MANUFACTURING METHOD THEREOF, AND APPLICATION THEREOF

The present disclosure provides a film composed of a polymer mixture, wherein the polymer mixture includes: a hydrophobic composition including polycaprolactone (PCL); and at least one hydrophilic polymer selected from a group consisting of alginate, gelatin, hyaluronic acid, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), collagen, demineralized bone matrix (DBM), bone morphogenetic protein (BMP), albumin, chitosan, fibrin, polyoxyethylene, polyvinylpyrrolidone, wherein the weight ratio of the hydrophobic composition to the hydrophilic polymer is about 1:0.01-100, and wherein the film has the effect of preventing leakage from a surgical wound or a diffuse wound. 1. A film , composed of a polymer mixture ,wherein the polymer mixture comprises:a hydrophobic composition comprising polycaprolactone (PCL); and 'alginate, gelatin, hyaluronic acid, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), collagen, demineralized bone matrix (DBM), bone morphogenetic protein (BMP), albumin, chitosan, fibrin, polyoxyethylene and polyvinylpyrrolidone,', 'at least one hydrophilic polymer, selected from a group consisting ofwherein a weight ratio of the hydrophobic composition to the at least one hydrophilic polymer is about 1:0.01-100.2. The film as claimed in claim 1 , wherein the at least one hydrophilic polymer is in the form of a solid particle.3. The film as claimed in claim 1 , wherein the at least one hydrophilic polymer is dissolved in a solvent to be in the form of a liquid polymer.4. The film as claimed in claim 1 , wherein the at least one hydrophilic polymer is alginate.5. The film as claimed in claim 4 , wherein the weight ratio of the hydrophobic composition to the alginate is about 1:0.05-80.6. The film as claimed in claim 1 , wherein the at least one hydrophilic polymer is gelatin.7. The film as claimed in claim 6 , wherein the weight ratio of the hydrophobic composition to the gelatin is about 1:0.05 ...

Adhesive for Use with Bone and Bone-Like Structures

An adhesive composition for bonding to bone and bone-like structures includes a polymerizable, multifunctional acidic monomer having a concentration ranging from about 5% to about 45% by weight of the adhesive composition, one or more multifunctional monomers with one or more ethylenically unsaturated groups having a concentration ranging from about 20% to about 60% by weight of the adhesive composition, an organically modified calcium phosphate salt with one or more pendant polymerizable groups having a concentration ranging from about 1% to about 50% by weight of the adhesive composition, and a polymerization initiator system. A method of forming the adhesive composition is also provided. 1. An adhesive composition for bonding to bone and bone-like structures , the composition comprising:a polymerizable, multifunctional acidic monomer having a concentration ranging from about 5% to about 45% by weight of the adhesive composition;one or more multifunctional monomers with one or more ethylenically unsaturated groups, the one or more multifunctional monomers having a concentration ranging from about 20% to about 60% by weight of the adhesive composition;an organically modified calcium phosphate salt having a concentration ranging from about 1% to about 50% by weight of the adhesive composition, the modified calcium phosphate salt having one or more pendant polymerizable groups; anda polymerization initiator system.2. The adhesive composition of claim 1 , wherein the multifunctional acidic monomer is bis[2-(methacryloyloxy)ethyl] phosphate claim 1 , glycerol dimethacrylate phosphate claim 1 , ethylene glycol methacrylate phosphate claim 1 , polyethylene glycol methacrylate phosphate claim 1 , methacryloyl ethyl oxy polycaprolactone phosphate claim 1 , allyl phosphate claim 1 , vinyl phosphonic acid claim 1 , 2-Acrylamido-2-methylpropanephosphonic acid claim 1 , methacryloyloxy decyl hydrogen phosphate claim 1 , methacryloyloxy ethyloxy phosphate claim 1 , 10- ...

HEMORRHAGE MANAGEMENT SYSTEM

An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (T) of the SMP foam to below 25° C. Other embodiments are described herein. 1. (canceled)2. A system comprising:a shape memory polymer (SMP) foam, including open cells, having first and second states; anda hydrogel (HG) included within the cells;wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located in a wound with the SMP foam in the first state; (b) in a second position the composite is configured to expand to the second state in the wound when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C.3. The system of claim 2 , wherein the SMP foam includes polyurethane and the HG includes Poly(ethylene glycol) Diacrylate (PEG-DA) N-vinylpyrrolidone (NVP) (PEG-DANVPHG).4. The system of claim 3 , wherein the SMP foam includes at least two of Hexamethylene diisocyanate (HDI) claim 3 , triethanolamine (TEA) claim 3 , hydroxypropyl ethylenediamine (HPED) claim 3 , or combinations thereof.5. The system of claim 2 , wherein the SMP foam actuates at body temperature.6. The system of claim 4 , wherein the HG includes an antimicrobial agent.7. The system of claim 6 , wherein the antimicrobial agent includes iodine.8. The system of claim 2 , wherein:the HG includes iodine and polyvinylpyrrolidone (PVP); andthe iodine is bound to the PVP.9. The system of comprising an applicator that includes the composite ...

ADHESIVE COMPOSITIONS AND PATCHES, AND ASSOCIATED SYSTEMS, KITS, AND METHODS

Adhesive compositions and patches, and associated systems, kits, and methods, are generally described. Certain of the adhesive compositions and patches can be used to treat tissues (e.g., in hemostatic or other tissue treatment applications), according to certain embodiments. 1. A water-activated adhesive article , comprising:a substrate; anda water activated polymeric adhesive disposed within a solvent and in contact with the substrate.2. The water-activated adhesive article of claim 1 , wherein the substrate is biodegradable.3. The water-activated adhesive article of any one of - claim 1 , wherein the substrate has a moisture content of less than about 20 wt %.4. The water-activated adhesive article of any one of - claim 1 , wherein the substrate has a water content of less than about 20 wt %.5. The water-activated adhesive article of any one of - claim 1 , wherein the substrate comprises a polymer.6. The water-activated adhesive article of any one of - claim 1 , wherein the substrate comprises a biopolymer.7. The water-activated adhesive article of any one of - claim 1 , wherein the substrate comprises a protein and/or a polysaccharide.8. The water-activated adhesive article of any one of - claim 1 , wherein the substrate comprises fibrin claim 1 , collagen claim 1 , cellulose claim 1 , starch claim 1 , chitosan claim 1 , hyaluronic acid claim 1 , polylactic acid claim 1 , polyglycolic acid and/or tissue-based materials.9. The water-activated adhesive article of any one of - claim 1 , wherein the substrate comprises fibrin.10. The water-activated adhesive article of any one of - claim 1 , wherein the substrate comprises a synthetic polymer.11. The water-activated adhesive article of any one of - claim 1 , wherein the substrate is substantially free of thrombin.12. The water-activated adhesive article of any one of - claim 1 , wherein the water-activated polymeric adhesive comprises the adhesive composition of any one of -.13. The water-activated adhesive article ...

CELL-SEEDED POROUS LUNG HYDROGEL SEALANT

Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak. 1. A biosealant composition comprising an extracellular matrix hydrogel and a thermogel;wherein the extracellular matrix hydrogel comprises a first extracellular matrix protein, an unbranched polysaccharide, and an elastic protein; andwherein the thermogel comprises a gelatinous material and a cross-linking enzyme in an amount sufficient to result in gelation of the thermogel at a temperature from about 35° C. to 37° C.2. The biosealant of claim 1 , wherein the first extracellular matrix protein is collagen claim 1 , wherein the elastic protein is elastin claim 1 , and wherein the unbranched polysaccharide is sulfated glycosaminoglycan.3. The biosealant of claim 1 , wherein the cross-linking enzyme is transglutaminase.4. The biosealant of claim 1 , wherein the extracellular matrix hydrogel also comprises additional therapeutics including cells claim 1 , microsomes claim 1 , peptides claim 1 , or drugs.5. The biosealant of claim 1 , wherein the cross-linking enzyme is present in an amount from about 0.5 units/mL to 5 units/mL.6. The biosealant of claim 1 , wherein the gelatinous material is gelatin.7. The biosealant of claim 1 , wherein the thermogel comprises pores of diameter of about 0.025 mm to 90 mm.8. The biosealant of claim 1 , wherein the biosealant composition does not contain fibrin.9. The biosealant of claim 1 , wherein the first extracellular matrix protein is present in an amount from about 25% by weight to about 75% by weight of the total weight of the first extracellular matrix protein claim 1 , unbranched polysaccharide claim 1 , and elastic protein of the extracellular matrix hydrogel.10. The biosealant of claim 1 , wherein the unbranched polysaccharide is present in an amount from about 0.5% by weight to about 15% by weight of the total weight of the first extracellular matrix protein claim 1 , ...

Hemorrhage management system

An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (T g ) of the SMP foam to below 25° C. Other embodiments are described herein.

Skin compatible composition

A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-skin.

Tissue-Adhesive Material

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend. 117.-. (canceled)18. A tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer , wherein the synthetic tissue-reactive polymer is based on a multi-arm polyethylene glycol and is functionalized with at least one tissue-reactive group that comprises an activated ester , wherein the tissue-reactive polymer has a molecular weight of 20000 g/mol or more.19. Tissue-adhesive polymer blend according to claim 18 , wherein the carrier polymer is a synthetic carrier polymer comprising polyesters claim 18 , polyethers claim 18 , polyhydroxyacids claim 18 , polylactones claim 18 , polyetheresters claim 18 , polycarbonates claim 18 , polydioxanes claim 18 , polyanhydrides claim 18 , polyurethanes claim 18 , polyester(ether)urethanes claim 18 , polyurethane urea claim 18 , polyamides claim 18 , polyesteramides claim 18 , poly-orthoesters claim 18 , polyaminoacids claim 18 , polyphosphonates claim 18 , polyphosphazenes and combinations thereof.20. Tissue-adhesive polymer blend according to claim 19 , wherein the synthetic carrier polymer comprises a poly(DL-lactide-co-ε-caprolactone) copolymer obtainable by the copolymerizaton of DL-lactide and ε-caprolactone.21. Tissue-adhesive polymer blend according to claim 18 , wherein the carrier polymer is a biological polymer comprising a polysaccharide.22. Tissue-adhesive polymer blend according to claim 18 , wherein the activated ester is selected from the group consisting of a thioester claim 18 , a perfluoroalkyl ester claim 18 , pentafluorophenol ester claim 18 , N-hydroxysuccinimide ester and derivatives thereof.23. Tissue-adhesive polymer blend according to claim 18 , wherein the tissue-reactive ...

DRUG CONTAINING CATIONIZED CHITOSAN

A task of the invention is to provide an art that inhibits the hemorrhagic activity exhibited by sulfated glycosaminoglycans, as well as a material, a medical material, and a drug that use a sulfated glycosaminoglycan while being free of the hemorrhaging problems caused by sulfated glycosaminoglycans and that can exhibit an excellent therapeutic effect on biological tissues. The present invention relates to an inhibitor of the hemorrhagic activity originating from sulfated glycosaminoglycans, the inhibitor having a cationized chitosan as an active ingredient. 1. A method for dressing a wound , the method comprising:covering the wound with a complex comprising a quaternary chitosan and a sulfated glycosaminoglycan selected from the group consisting of a heparin and a chondroitin sulfate,{'sub': '1-4', 'wherein the quaternary chitosan is a chitosan molecule to which a Calkyl ammonium group is covalently bonded at an amino group of the chitosan molecule.'}2. The method for dressing a wound according to claim 1 , wherein the quaternary chitosan is N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride.3. A method for treating a wound claim 1 , the method comprising:applying a complex comprising a quaternary chitosan and a sulfated glycosaminoglycan selected from the group consisting of a heparin and a chondroitin sulfate, to a subject in need thereof,{'sub': '1-4', 'wherein the quaternary chitosan is a chitosan molecule to which a Calkyl ammonium group is covalently bonded at an amino group of the chitosan molecule.'}4. The method for treating a wound according to claim 3 , wherein the quaternary chitosan is N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride. This application is a Divisional application of Ser. No. 14/911,793 which is the National Stage of International Application No. PCT/JP2014/070946, filed on Aug. 7, 2014, which claims priority from Japanese Patent Application No. 2013-168324, filed on Aug. 13, 2013, the contents of all of which are ...

MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES

The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) 110.-. (canceled)12. The method according to claim 11 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas.13. The method according to claim 12 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the organic fillers.14. The method according to claim 11 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester.15. The method according to claim 14 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with organic fillers.16. The method according to claim 11 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas and wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester and the organic fillers.17. The method according to claim 11 , wherein the polyol component has a number-average molecular weight of 4000 to 8500 g/mol.18. The method according to claim 11 , wherein the polyol component comprises a polyalkylene oxide polyether.19. The method according to claim 18 , wherein the polyalkylene oxide polyether contain from 60% to 90% of ethylene oxide-based units claim 18 , based on the total amount of alkylene oxide units.20. The method according to claim 12 , wherein the organic fillers comprise polyether polyols.21. The method according to claim 11 , wherein the formulation is cured for a period of time from 30 seconds to 10 minutes.22. The method according to claim 11 , wherein ...

MINERALIZED COLLAGEN COMPOSITE BONE CEMENTING AND FILLING MATERIAL

To cover shortages of existing PMMA bone cement products, including very high hardness and poor biocompatibility, the invention provides a mineralized collagen incorporated PMMA bone adhesive and filling material. Mineralized collagen (MC) is prepared via an in vitro biomimetic mineralization process and has a chemical composition and structure of self-assembled nano-sized calcium phosphate and collagen molecules, thus possessing biomimetic mineralized structure and mechanical properties similar to natural human bone, good biocompatibility, osteogenic activity and biodegradation ability. An MC incorporated bone adhesive and filling material with high compressive strength and low elastic modulus, and improved biocompatibility compared to pure PMMA bone cements may be obtained. Such bone adhesive and filling materials reduce the risk of abrading the host bone tissue and avoiding damage of the implant caused by extrusion, and form osteointegration with the host bone, improving the stability of the bone adhesive and filling materials at the implantation site.

STABLE AND ROBUST BLENDED HEMOSTATIC COMPOSITION

A hemostatic composition of matter includes a coherent blend of collagen fibrils combined with starch particles as a fluffy mass with hemostatic properties better than collagen fibrils alone or starch particles alone, the composition exhibiting a level of coherence wherein the composition can be lifted, without crushing fibrils, without loss of more than 5% of 10% of a total weight of starch particles from the composition. Sheets with less than 10% by weight of additional binder are also disclosed. 1. A composition of matter comprising a coherent blend of collagen fibrils combined with starch particles as a fluffy mass with hemostatic properties better than collagen fibrils alone and starch particles alone , the composition exhibiting a level of coherence wherein the composition can be lifted , without crushing fibrils and without loss of more than 10% by total weight of starch particles.2. The composition of wherein the composition can be lifted without crushing fibrils and without loss of more than 5% of a total weight of the composition as starch particles from the composition upon lifting.3. The composition of wherein the collagen fibrils have an average length of less than 1000 μm.4. The composition of wherein the starch particles have an average diameter of less than 1000 μm.5. A method of forming a coherent and stable composition of matter comprising a coherent blend of collagen fibrils combined with starch particles as a fluffy mass with hemostatic properties by physically admixing collagen fibrils and starch particles together in a weigh ration of from 2% to 95% by total weight of the composition as collagen fibrils and from 98% to 5% by total weight of starch particles6. The method of wherein the admixing is performed for at least 15 seconds with a force that is insufficient to reduced the average collagen fibrils length by more than 10%.7. The method of wherein the collagen fibrils have an average length of less than 1000 μm.8. The method of wherein the ...

Einkomponenten-Knochenzementpasten und Verfahren zu deren Aushärtung

Einkomponenten-Knochenzementpasten, insbesondere enthaltend: AI mindestens ein radikalisch polymerisierbares Methacrylatmonomer; AII mindestens ein in AI lösliches Polymer; AIII mindestens ein in AI nicht lösliches partikuläres Polymer mit einer Partikelgröße kleiner 500 µm; optional AIV mindestens einen aktivierbaren Initiator, insbesondere mindestens einen radikalbildenden Initiator oder mindestens einen in AI löslichen, thermisch zerfallenden radikalischen Initiator; optional AV mindestens einen elektrisch leitfähigen Röntgenopaker, besonders als ferromagnetische Partikel; eignen sich z.B. zur Herstellung von pastenförmigen Zweikomponenten-Knochenzementen, zur Herstellung von Mitteln zur Fixierung von Totalendoprothesen und Revisionsendoprothesen, zur Herstellung von selbsthärtenden Füllmaterialien für die Vertebroplastie, Kyphoplastie oder Femurhalsaugmentation, oder zur Herstellung von lokalen Wirkstofffreisetzungssystemen, und können bei Anwesenheit der Komponente AV mit magnetischen Wechselfeldern von 500 Hz bis 50 kHz oder durch Induktion bis zum Einsetzen des Zerfalls eines Initiators AIV erwärmt werden. Daraus ergibt sich auch ein Verfahren zum Härten von Pasten enthaltend mindestens einen aktivierbaren Initiator, insbesondere mindestens einen radikalbildenden Initiator oder mindestens einen thermisch zerfallenden radikalischen Initiator; und mindestens elektrisch leitfähige Partikel ...

用于湿润组织的粘合剂和使用该粘合剂制成的造口缘装置

一种用于湿润组织的粘合剂，包括一种硅橡胶，一种交联聚丙烯酸聚合物和一种聚丙烯酸钠基高吸水性聚合物。所述粘合剂很好地粘附到湿润组织，如粘膜皮肤表面。本发明还公开了一种造口皮肤屏障，包括使用所述粘合剂制造的一个造口密封件。

Adhesive for ostomy and adhesive tape comprising the same

The present invention relates to an adhesive for ostomy and an adhesive tape for ostomy comprising the same. Specifically, the present invention relates to an adhesive for ostomy, which can be attached to an affected area with high adhesion, and has improved functionality to facilitate detachment from the skin; and to an adhesive tape for ostomy comprising the same. The adhesive for ostomy includes acrylic resins and rubber resins.

具有低残余mma含量的高冲击韧性透明假体材料

本发明的主题是可自聚合的双组分假体基材、含有该材料的试剂盒、以及其制造方法，该假体基材包含至少一种液体单体组分(A)和至少一种粉状组分(B)，其中所述假体材料在组分(A)中除了甲基丙烯酸甲酯外含有至少一种摩尔质量为小于等于250 g/mol的N‑烷基‑取代的丙烯酰氧基‑氨基甲酸酯、任选的至少一种至少二官能氨基甲酸酯(甲基)丙烯酸酯、不是氨基甲酸酯(甲基)丙烯酸酯的二‑、三‑、四‑、或多‑官能单体、和任选的初级粒度为小于800 nm的聚合物颗粒，且粉状组分(B)包含聚合物颗粒，其具有至少三种不同的粒度级分，并且(A)和(B)两者都含有用于自聚合的至少一种引发剂或至少一种引发剂体系组分。

Random and non-random alkylene oxide polymer alloy compositions

A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.

Biodegradable tissue adhesive patch and preparation method thereof

本文公开了一种生物可降解的组织粘合贴片及其制备方法，该组织粘合贴片包括：组织粘附层和防粘层，其中，所述组织粘附层包含提供组织粘附性的多元聚合物基体和分散于所述多元聚合物基体中的增韧聚合物，所述防粘层包括具有成膜性的聚合物。本发明的组织粘合贴片具有强粘附力并且抗破裂性能优异。

Biodegradable bone cement

A surgical bonding material includes a continuous phase and a discontinuous phase. The continuous phase is formed from a polymerizable liquid. The discontinuous phase includes particles of bioabsorbable polymer. The bonding material may be partially or completely bioabsorbable.

Curable two-part acrylic composition and method for producing the same

Composition

Chitosan-based efficient hemostatic with Janus structure and preparation method and application thereof

本发明公开了一种具有Janus结构的壳聚糖基高效复合止血剂，属于生物医药材料技术领域，主要成分为甲基丙烯酸酐、壳聚糖、碳酸钙及质子化酸式盐，该止血剂由如下方法制得：制备甲基丙烯酸化壳聚糖，将改性后壳聚糖与碳酸钙、光引发剂等混合后滴入羧化壳聚糖水溶液中，形成具有壳层结构的水凝胶微球，然后通过光交联、离子交换、冷冻干燥等方法得到Janus壳聚糖/碳酸钙颗粒，随后与质子化酸式盐粉末混合得到具有定向推进的具有Janus结构的壳聚糖基高效止血剂；本发明的高效复合止血剂，具有驱动性、吸水性和激活内源性凝血机制的作用，能够用于不规则创口的快速止血。

Albumin composite adhesive and preparation method thereof

本发明提供一种白蛋白复合粘合剂及其制备方法，该白蛋白复合粘合剂包括牛血清白蛋白、明胶。本发明的白蛋白复合粘合剂通过非共价作用交联连接，具有较强的界面粘结力及内聚力；其制备工艺简单，具有良好的生物相容性及降解性，适用于皮肤美容修复及术后伤口愈合。

Silk fibroin and polyethylene glycol-based biomaterials

This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and maleimides functionalized PEGs) that are additionally stabilized by the beta-sheet formation of silk fibroin. The crosslinked silk-PEGs biomaterials present strong adhesive properties, which are comparable to or better than the current leading PEG-based sealant, depending on the silk concentration in the silk-PEGs biomaterials. In addition, the silk-PEGs based biomaterials are cytocompatible, show decreased swelling behavior and longer degradation times, which make them suitable for hemostatic applications where the current available tissue sealant products can be contraindicated.

Bone cement with sustained drug release behavior

본 발명은 약물을 포함하는 골 시멘트 매트릭스, 및 양친매성 첨가제(amphiphilic additive)를 포함하는 골 시멘트에 관한 것으로, 본 발명에 따른 양친매성 첨가제가 포함된 약물 함유 골 시멘트는 국소 환부에 적용 시, 골 시멘트에 유의한 물성변화를 야기하지 않을 정도의 양친매성 첨가제를 첨가하여도 골 시멘트 내에 포함된 약물을 국소 환부에 보다 장기적이며 효율적으로 전달할 수 있어 현재까지 임상에서 선택의 여지없이 사용하고 있는, 시술 초기에만 항균효과를 가지는, 기존 약물 포함 골 시멘트를 대체할 수 있는 효과를 가진다. The present invention relates to a bone cement matrix comprising a drug, and a bone cement including an amphiphilic additive. When the drug-containing bone cement containing an amphipathic additive according to the present invention is applied to a localized part, The addition of an amphipathic additive that does not cause significant physical property changes in cement can deliver the drug contained in bone cement to the local lesion in a longer period and more efficiently, It is possible to replace the existing bone cement containing drug.

Complex biological adhesive seal agent

本发明公开一试剂套件及一生物粘着剂，包含：明胶、藻酸盐、蒙脱石及一偶联剂，特征为快速固化、最佳粘度、高爆裂强度、柔韧性、生物相容性及生物降解性。

Medicinal adhesives for stilling heavy bleeding and sealing leaks

Die vorliegende Erfindung betrifft neuartige, schnell härtende Klebstoffe auf Basis hydrophiler Polyisocyanat-Prepolymere für den Einsatz in der Chirurgie zur Stillung schwerwiegender Blutungen (Hämostase) und Abdichtung von Leckagen.

Embolic compositions and methods

一种用于控制栓塞组合物的凝固的栓塞系统和方法，所述栓塞组合物包括在体内在目标部位彼此反应形成栓塞材料的第一栓塞成分和第二栓塞成分，所述栓塞成分可在生理液中稀释，从而它们不会在不需要的部位形成栓塞组合物。

Adhesive material for rigid living tissue

Cross-linked hemostatic sponge with hemostatic and postoperative anti-tumor functions and preparation method thereof

本发明提供了一种兼具止血和术后抗肿瘤功能的交联止血海绵，该交联止血海绵由交联的改性透明质酸和胶原蛋白类物质形成的复合三维网络结构，以及分布在复合三维网络结构中的控释载药纳米粒子组成，具有多孔结构，所述交联的改性透明质酸由改性透明质酸自交联形成，所述控释载药纳米粒子通过化学键与交联的改性透明质酸结合，所述控释载药纳米粒子所负载的药物为抗肿瘤药物。本发明提供的交联止血海绵通不但能减少出血并降低循环肿瘤细胞数量，而且可通过其中交联负载的药物共递送纳米粒子向残余肿瘤细胞及散落肿瘤细胞中缓释控释抗肿瘤药物，持续性杀伤癌细胞，有效抑制术后肿瘤的复发和转移。

BODY WASTE COLLECTOR DEVICE

dispositivo coletor de excretos corporais o pedido revela um dispositivo coletor de excretos corporais que compreende uma bolsa coletora e uma placa adesiva para fixação à pele, a referida placa compreendendo uma camada de suporte e uma primeira e segunda camada de adesivo hidrocoloide, em que a segunda camada de adesivo hidrocoloide esté pelo menos parcialmente interposta entre a primeira acamada adesivo hidrocoloide e a camada de suporte, sendo que a primeira e segunda camadas adesivas consistem de uma fase contínua e uma fase descontínua, em que a) a fase descontínua da primeira camada adesiva compreende pectina, carboximetilcelulose, gelatina, goma guar e amido de batata, b) a fase descontínua da segunda camada adesiva compreende carboximeticelulose, gelatina e goma guar, c) a composição da fase contínua da primeira camada adesiva compreende um poliisobutileno, um copolímero em bloco de estireno, uma borracha de butila e um promotor de pegajosidade, d) a composição da fase contínua da segunda camada adesiva consiste de poliisobutileno e copolímero em bloco de estireno. The body excreta collection device The application discloses a body excrete collection device comprising a collection bag and an adhesive plate for securing the skin, said plate comprising a backing layer and a first and second hydrocolloid adhesive layer, wherein the second The hydrocolloid adhesive layer is at least partially interposed between the first hydrocolloid adhesive layer and the backing layer, the first and second adhesive layers consisting of a continuous phase and a discontinuous phase, wherein a) the discontinuous phase of the first adhesive layer comprises pectin, carboxymethylcellulose, gelatin, guar gum and potato starch, b) the discontinuous phase of the second adhesive layer comprises carboxymethicellulose, gelatin and guar gum, c) the continuous phase composition of the first adhesive layer comprises a polyisobutylene, a block copolymer styrene, a butyl rubber and a tackifier ...

A kind of high power water-absorbing antibacterial anti hemorrhagic uses sponge

发明公开了一种高倍吸水抗菌止血用海绵，由以下成分制成：变性淀粉、胶原蛋白、壳聚糖‑冬凌草配合物、水凝胶。本发明制备的止血海绵能与创面组织紧密粘附，促进凝血，凝血块与按压的纱布敷料不发生粘连，不会造成再次出血。

High-impact, transparent prosthesis material having a low residual mma content

The invention relates to an autopolymerisable 2-component prosthesis base material, to a kit containing the material, and to a method for production thereof comprising at least one liquid monomer component (A), and at least one component (B) in powder form, wherein the prosthesis material in the component (A) contains, in addition to methyl methacrylate, at least one N-alkyl-substituted acryloyloxy carbamate having a molar mass of less than or equal to 250 g/mol, optionally at least one at least difunctional urethane(meth)acrylate, ein di-, tri-, tetra-, or multi-functional monomer which is not a urethane(meth)acrylate, and optionally polymeric particles having a primary particle size of less than 800 nm, and the component (B) in powder form comprises polymeric particles having at least three different particle size fractions and both (A) and (B) contain at least one initiator or at least one component of an initiator system for the autopolymerisation.

High-impact, transparent prosthesis material having a low residual mma content

A kind of absorbable hemostasis bone wax and preparation method thereof

本发明提供了一种可吸收的止血骨蜡及其制备方法，所述止血骨蜡由明胶和泊洛沙姆组成，其中明胶与泊洛沙姆的质量之比为1:1~9:1。本发明提供的止血骨蜡具有可降解性、优异的物理封堵效果以及止血性能。另外，本发明止血骨蜡的制备方法是通过将交联明胶进行充分溶胀后，进行机械粉碎、冷冻干燥及二次粉碎，然后再溶胀于泊洛沙姆溶液中，再次冷冻干燥得到。本发明的制备方法工艺简单，制备的止血骨蜡具有合适的体积溶胀率以及饱和吸水率，止血骨蜡的降解时间为8周~50周，爆破压力不低于60mmHg，具有良好的封堵效果，可广泛应用于骨科止血领域。

Porous bone substitute materials

Biomaterials based on silk fibroin and polyethylene glycol

High-impact, transparent denture material with low residual MMA content

Gegenstand der Erfindung ist ein autopolymerisierbares 2-Komponenten-Prothesenbasismaterial, ein Kit enthaltend das Material sowie ein Verfahren zu seiner Herstellung umfassend mindestens eine flüssige Monomerkomponente (A), und mindestens eine pulverförmige Komponente (B), wobei das Prothesenmaterial in der Komponente (A) neben Methylmethacylat, mindestens ein N-Alkyl-substituiertes Acryloyloxy-Carbamat mit einer Molmasse von kleiner gleich 250 g/mol, optional mindestens ein mindestens difunktionelles Urethan(meth)acrylat, ein di-, tri-, tetra- oder multi-funktionelles Monomer, das kein Urethan(meth)acrylat ist, und optional polymere Partikel mit einer Primärpartikelgröße von kleiner 800 nm, enthält und die pulverförmige Komponente (B) umfasst polymere Partikel mit mindestens drei verschiedenen Partikelgrößenfraktionen und sowohl (A) und (B) enthalten mindestens einen Initiator oder mindestens eine Komponente eines Initiatorsystems für die Autopolymerisation. The invention relates to an autopolymerizable 2-component prosthesis base material, a kit containing the material and a method for its preparation comprising at least one liquid monomer component (A), and at least one powdery component (B), wherein the prosthesis material in the component (A) in addition to methyl methacylate, at least one N-alkyl-substituted acryloyloxy carbamate having a molecular weight of less than or equal to 250 g / mol, optionally at least one at least difunctional urethane (meth) acrylate, a di-, tri-, tetra- or multi-functional monomer, which is not a urethane (meth) acrylate, and optionally contains polymeric particles having a primary particle size of less than 800 nm, and the powdery component (B) comprises polymeric particles having at least three different particle size fractions and both (A) and (B) contain at least one initiator or at least one component of an initiator system for autopolymerization.

Bioactive flowable wash-out resistant bone graft material and method for production thereof

The present disclosure relates to a flowable bone graft material including an inorganic composition comprising calcium phosphate having a particle size of about 100 pm to about 1,000 pm, bioactive glass, and one or more biocompatible polymers comprising carboxymethyl cellulose and a fluid.

Bioactive materials, methods of making bioactive materials and method of use thereof

利用可单独使用或作为与颗粒如核/壳颗粒的组合物的丝心蛋白溶液和混悬液制备生物活性物质。将物质设计成支持机体的骨和其它组织的构建，修复，再生或增加。该溶液和混悬液可被装有核/壳型颗粒，所述核/壳颗粒包含被具有磷酸钙前体的外涂层的可生物降解聚合物包被的无机核颗粒。丝心蛋白溶液，混悬液，和组合物可被注射以填充空腔或代替缺少的组织。注射后，该物质可产生能促进组织再生、同时降解的支架。当存在时，颗粒的降解可在支架内产生额外的孔，并以可控制的方式释放其它化合物以增强组织修复所需的生长和细胞活化。注射丝心蛋白溶液，混悬液和组合物的能力可降低用于替换或修复骨和其它组织的很多类型外科外科手术程序的需要。

MATERIALS IN THE FORM OF INTERPENETRATING POLYMER ARRAYS ASSOCIATING A FIBRIN GEL AND A POLYETHYLENE GLYCOL NETWORK

ADHESIVE COMPOSITION AND FIXING MEMBER ON HUMAN SKIN

L'invention a pour objet une composition adhésive destinée à assurer la fixation sur la peau humaine, comprenant une phase continue et une phase discontinue d'hydrocolloïdes,, la phase continue comprenant en poids, sur la base du poids total de la composition adhésive : (i) 1 à 12% en poids d'un polymère séquencé de type styrène-isoprène-styrène ou styrène-butadiène-styrène, (ii) (a) 1 à 15% d'un polymère de type élastomère butyl, éventuellement en mélange avec jusqu'à 25% en poids de d'un polymère de type polyisobutylène, ou (b) plus de 10% à 30% d'un polymère de type polyisobutylène, exempt de polymère de type élastomère butyl, (iii) 1 à moins de 10% d'un polymère de type éthylène vinyl acétate, la somme de ces trois types de polymères représentant de 10 à 40%. The invention relates to an adhesive composition for fixing on human skin, comprising a continuous phase and a discontinuous phase of hydrocolloids, the continuous phase comprising, by weight, based on the total weight of the adhesive composition: (I) 1 to 12% by weight of a styrene-isoprene-styrene or styrene-butadiene-styrene block polymer, (ii) (a) 1 to 15% of a butyl elastomeric polymer, optionally in admixture with up to 25% by weight of a polyisobutylene type polymer, or (b) more than 10% to 30% of a polyisobutylene type polymer, free of butyl elastomeric polymer, (iii) 1 at least 10% of an ethylene vinyl acetate type polymer, the sum of these three types of polymers representing from 10 to 40%.

The preparation method of hemostasis Cellulose/Chitosan complex microsphere

本发明公开了一种止血用纤维素/壳聚糖复合微球的制备方法，步骤如下：1）制备纤维素/壳聚糖复合溶液2）制备纤维素/壳聚糖复合微球3）制备止血用纤维素/壳聚糖复合微球：将步骤2）制得的纤维素/壳聚糖复合微球进行化学改性处理，得到羧基化纤维素/壳聚糖复合微球；然后将羧基化纤维素/壳聚糖复合微球浸润在活化剂中，加入凝血或促凝血物质反应一段时间后，经过蒸馏水洗涤除去杂质，得到止血用纤维素/壳聚糖复合微球；本发明制备的止血用纤维素/壳聚糖复合微球止血效果好，可以用于急性创面出血区止血。

MEDICAL ADHESIVES FOR STOPING HEAVY BLEEDING AND SEALING FROM LEAKAGE LIQUID

1. Применение составов, включающих ! A) изоцианат-функциональные преполимеры, которые могут быть получены из ! А1) алифатических изоцианатов и ! А2) полиолов со среднечисленными молекулярными весами ≥400 г/моль и средними НО-функциональностями от 2 до 6, ! B) отверждающий компонент, включающий ! В1) аминофункциональный эфир аспарагиновой кислоты формулы (I) ! , ! при этом X является n-валентным органическим остатком, который получается за счет удаления первичных аминогрупп n-валентного амина, ! R1, R2 являются одинаковыми или различными органическими остатками, которые не обнаруживают активного водорода по Церевитинову и ! n - целое число по меньшей мере 2, ! и при необходимости ! В2) органические наполнители, которые имеют вязкость, измеренную по DIN 53019 при 23°C, в диапазоне от 10 до 6000 мПа ! и ! C) при необходимости продукты взаимодействия изоцианат-функциональных преполимеров согласно определению компонента A) с эфирами аспарагиновой кислоты согласно компонента В1) и/или органические наполнители согласно компонента В2) для остановки вытекания крови или тканевых жидкостей или закрытия ран от утечек жидкости в клеточных тканях. ! 2. Способ остановки вытекания крови или тканевых жидкостей или закрытия ран от утечек жидкости в клеточных тканях, при котором составы, включающие ! A) изоцианат-функциональные преполимеры, которые могут быть получены из ! А1) алифатических изоцианатов и ! А2) полиолов со среднечисленным молекулярным весом ≥400 г/моль и средними НО-функциональностями от 2 до 6, ! B) отверждающий компонент, включающий ! В1) аминофункциональный эфир аспарагиновой кислоты формулы (I) ! , ! при этом ! X является n-валентным органи РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2011 105 724 (13) A (51) МПК A61L 24/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2011105724/15, 04.07.2009 (71) Заявитель(и): БАЙЕР МАТИРИАЛЬСАЙЕНС АГ (DE) Приоритет(ы): (30) Конвенционный приоритет: 17.07.2008 EP 08012901.8 (85) ...

Light-activated adhesive composite, system, and methods

The present invention provides a light-activated adhesive composite suitable for medical and surgical applications. The composite includes a scaffold and a light-activated adhesive, such as a laser tissue solder. The scaffold includes a biological, 5 biocompatible, or biodegradable material, such as PLGA or SIS.

Medicine containing cationized chitosan

Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from chitosan and including a polymer mesh material of poly-4-hydroxy butyrate

키토산 물질로 이루어진 과립 또는 입자는 내부에 폴리-4-히드록시 부티레이트의 중합체 망상 물질을 보유하거나, 또는 폴리-4-히드록시 부티레이트의 중합체 망상 물질이 산재된다. 과립 또는 입자는 필수적으로 폴리-4-히드록시 부티레이트로 구성된 물질로 이루어진 중합체 망상 소클렛 내에 보유될 수 있다. 과립 또는 입자는 강내 출혈을 처리하기 위해 사용될 수 있다. 폴리-4-히드록시 부티레이트, 중합체 망상 물질, 키토산 물질, 과립, 입자.

Hemostatic sponge

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that - said polymeric component is coated onto a surface of said matrix of a biomaterial, or - said matrix is impregnated with said polymeric material, or - both.

Hemostatic compositions

The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.

Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue

A composite viscoelastic hydrogel comprises a continuous phase of non-crosslinked hyaluronic acid gel and a dispersed phase of dehydrothermally-crosslinked micron-sized gelatin hydrogel particles. The hydrogel exhibits a storage modulus (G') of greater than 400Pa and a tan δ (G''/G') from 0.1 to 0.8 in dynamic viscoelasticity measured by a rheometer at 1Hz and 1% strain rate at 25°C. The dehydrothermally crosslinked micron-sized gelatin hydrogel particles have an average dimension of less than 100 microns prior to hydration.

Hemostatic sponge

Adhesive composition and fixing element for human skin

Composición adhesiva para asegurar la fijación sobre la piel humana, que comprende una fase continua y una fase discontinua de hidrocoloides, comprendiendo la fase continua en peso, basándose en el peso total de la composición adhesiva: (i) del 1 % al 12 % en peso de un polímero secuenciado del tipo estireno-isopreno-estireno o estireno- butadieno-estireno, (ii) (a) del 1 % al 15 % de un polímero de tipo elastómero de butilo, opcionalmente en una mezcla con hasta un 25 % en peso de un polímero de tipo poliisobutileno, (iii) del 1 % a menos del 10 % de un polímero del tipo etileno y acetato de vinilo, representando la suma de estos tres tipos de polímeros del 10 % al 40 %, estando dicha composición sustancialmente exenta de aceite polar y/o en la que la fase polar representa menos del 10 % en peso. Adhesive composition to ensure fixation on human skin, comprising a continuous phase and a discontinuous phase of hydrocolloids, the continuous phase comprising by weight, based on the total weight of the adhesive composition: (i) from 1% to 12% by weight weight of a block polymer of the styrene-isoprene-styrene or styrene-butadiene-styrene type, (ii) (a) from 1% to 15% of a polymer of the butyl elastomer type, optionally in a mixture with up to 25% in weight of a polymer of the polyisobutylene type, (iii) from 1% to less than 10% of a polymer of the ethylene and vinyl acetate type, the sum of these three types of polymers representing 10% to 40%, said composition being substantially free of polar oil and/or in which the polar phase represents less than 10% by weight.

Random ethylene oxide copolymer and non-random alkylene oxide(s) polymer

A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.

Stimulus-sensitive material and medical material containing it

FIELD: medicine. SUBSTANCE: temperature-sensitive medical anti-solder material contains a temperature-sensitive polymer in an amount of 10-50 wt %, fibers in an amount of 0.5-10 wt % and water, where the fibers dispersed in the temperature sensitive polymer have a number-average diameter of 1 to 900 nm. The temperature-sensitive polymer and fiber have a common basic chemical structure selected from the following combinations: the fiber includes lactic acid units -O-CH(CH 3 )-CO-, while the temperature-sensitive polymer includes lactic acid units -O-CH(CH 3 )-CO-, or the fiber includes nylon 6 -CH 2 CH 2 CH 2 CH 2 CH 2 -CO-NH-. The temperature-sensitive polymer includes amide units -CO-NH-, and the weight ratio of the temperature-sensitive polymer to the fibers is 5 to 100. The invention provides creation of a material in which both ease of use and mechanical properties are achieved at the same time. EFFECT: invention is favorable for sol-gel transition of between the liquid and solid state. 10 cl, 2 tbl, 13 ex С 2 2625761 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) (11) м зе зе в (13) > зов 2549 С2 (51) МПК АбИК 9/70 (2006.01) Аб!К 4730 (2006.01) В82У 500 (2011.01) А61Р41/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2014136336, 29.01.2013 (24) Дата начала отсчета срока действия патента: 29.01.2013 Дата регистрации: 18.07.2017 Приоритет(ы): (30) Конвенционный приоритет: 08.02.2012 ]Р 2012-024673; 08.02.2012 ]Р 2012-024674; 28.06.2012 1Р 2012-145164; 11.07.2012 ТР 2012-155261; 11.07.2012 ТР 2012-155262; 17.10.2012 ТР 2012-229573 (43) Дата публикации заявки: 10.04.2016 Бюл. № 10 (45) Опубликовано: 18.07.2017 Бюл. № 20 (85) Дата начала рассмотрения заявки РСТ на национальной фазе: 08.09.2014 (86) Заявка РСТ: ]Р 2013/051813 (29.01.2013) (87) Публикация заявки РСТ: УГО 2013/118605 (15.08.2013) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (72) ...

Bioactive material, method for producing bioactive material and method of use thereof

Mineralized collagen composite bone cementing and filling material

Mineralized collagen composite PMMA bone cementing and filling material, the mineralized collagen employs in-vitro biomimetic mineralization technology and is self-assembled by nano-calcium phosphate and collagen molecules. The mineralized collagen has a biomimetic mineralization structure and mechanical properties similar to natural bones of a human body, and has good biocompatibility and bone-forming activity, and biodegradability. The material has both high compressive strength and low elasticity modulus, and improved biocompatibility compared with pure PMMA cement. The material can reduce the risk of wearing of autogenous bones of a patient and avoid damage to implanted prostheses caused by pressure, and can form synostosis with autogenous bones to improve the stability of the bone cementing and filling material at an implant site, thus effectively reducing complications.

Crystal gel for stopping bleeding and bearing anticancer drugs and preparation method thereof

本发明公开了一种用于止血并承载抗癌药物的晶胶及其制备方法，该制备方法先将双键修饰到生物大分子上，多酚类化合物接枝到生物大分子上，利用多巴胺分子和Zn 2+ 离子的配位作用，制备多巴胺修饰的ZIF‑8。将各组分分别制备成水溶液或分散液，之后在引发剂的作用下，通过双键聚合，于低温下形成多功能水/血液触发的形状记忆晶胶。本发明以具有良好的生物相容性和降解性能的多糖等生物大分子为基础，化学接枝双键或多酚类化合物的过程，同样具有低毒无污染特征本发明使用的双键官能化的生物大分子制备简单，合成技术成熟，所制备的产物具有很好的通用型。

A hardenable two part acrylic composition

본 발명은 경화성 이제형 아크릴 조성물, 이 이제형 경화성 조성물의 고분자 성분과 이 이제형 조성물의 고분자 성분을 제조하는 방법에 관한 것이다. 상기 경화성 이제형 아크릴 조성물은 아크릴 고분자 조성물인 제1제와 아크릴 모노머 조성물인 제2제를 포함한다. 이 아크릴 고분자 조성물 제1제는 제1 형태의아크릴 고분자 입자를 갖추고 있는데, 그 특징은 이 제1 형태의아크릴 고분자 입자의 각각이 합일된 유화 중합 아크릴 미세입자들의 네트워크로 형성되거나 미세다공성이라는 데 있다. 상기 아크릴 고분자 조성물은 입자 크기가 10 내지 2000 nm인 유화 중합된 아크릴 고분자 입자를 포함할 수 있다. 본 발명은 또한 합일된 유화 중합 아크릴 미세입자의 네트워크로 이루어진 아크릴 고분자 입자를 경화성 이제형 아크릴 조성물의 반죽 시간 단축제로 사용하는 것에도 미친다. The present invention relates to a curable ready-to-use acrylic composition, a polymer component of the present curable composition, and a method of making a polymer component of the present composition. The curable ready-to-use acrylic composition comprises a first agent which is an acrylic polymer composition and a second agent which is an acrylic monomer composition. The first acrylic polymer composition composition has a first type of acrylic polymer particles characterized in that each of the first type of acrylic polymer particles is formed by a network of emulsion polymerized acrylic fine particles or is microporous . The acrylic polymer composition may include emulsion-polymerized acrylic polymer particles having a particle size of 10 to 2000 nm. The present invention also relates to the use of acrylic polymer particles consisting of a network of coalesced emulsion polymerized acrylic microparticles as a kneading time shortening agent for a curable ready-to-use acrylic composition.

Tissue-adhesive material

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend. The carrier polymer may be a synthetic carrier polymer comprising polyesters, polyethers, polyhydroxyacids, polylactones, polyetheresters, polycarbonates, polydioxanes, polyanhydrides, polyurethanes, polyester(ether)urethanes, polyurethane urea, polyamides, polyesteramides, poly-orthoesters, polyaminoacids, polyphosphonates, polyphosphazenes and combinations thereof.

Curable bone cement

The present invention describes a curable bone cement. The cement comprises a curable polymeric binder and a filler, and is capable of curing without substantial evolution of heat on exposure to a curing agent. The binder comprises phenol groups which are capable of reacting in order to cure the cement.

Composite bioadhesive sealant

A kit and a bioadhesive, comprising gelatin, alginate, montmorillonite and a coupling agent, which is characterized by rapid curing, optimal viscosity, high burst strength, flexibility, biocompatibility and biodegradability, is disclosed.

Adhesive composition and element for attachment to human skin

FIELD: medicine. SUBSTANCE: invention relates to the creation of an adhesive composition intended for providing the attachment to the human skin and an element for the attachment of a container for collecting organism fluids. The adhesive composition contains a continuous phase and a dispersed phase of hydrocolloids. The continuous phase contains, by weight, per the total weight of the adhesive composition: (i) from 1 to 12 wt. % of block-copolymer of a styrene-isoprene-styrene or styrene-butadiene-styrene type, (ii) (a) from 1 to 15 wt.% of polymer of an elastomeric butyl type, optionally in a mixture with up to 25 wt.% of polymer of a poly-isobutylene type, or (b) from more than 10 wt.% to 30 wt.% of polymer of a poly-isobutylene type that does not contain polymer of an elastomeric butyl type, (iii) from 1 to less than 10 wt.% of polymer of an ethylene-vinyl acetate type. In total, polymers of the above-mentioned three types are from 10 to 40 wt.%. In the adhesive composition, polar oil is essentially absent and/or a polar phase is less than 10 wt.%. The composition contains from 40 to 60 wt.% of the dispersed phase of hydrocolloids. EFFECT: obtaining a composition, characterized in high “adhesiveness”, to provide the possibility of quick application to the skin, tight attachment by means of tight fit to the stomach surface in order to withstand the weight of the container and other limits imposed by it, as well as coupling for removal without difficult and without a trace. 11 cl, 1 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 763 497 C2 (51) МПК A61F 5/44 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 15/58 (2006.01) C09J 151/00 (2006.01) B32B 27/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА B32B 27/30 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ B32B 27/32 (2006.01) (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61F 5/44 (2021.08); A61L 24/00 (2021.08); A61L 24/04 (2021.08); A61L 15/58 (2021.08); C09J 151/00 (2021.08); B32B 27/00 (2021.08); B32B 27/30 (2021.08); B32B ...

Cell-seeded porous lung hydrogel sealant

Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.