04-01-2018 дата публикации
Номер: US20180000992A1
Принадлежит:
Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided. 1. A device for restoring fat loss-related tissue volume loss in the face , the device comprising:a syringe;a sterile viscoelastic gel contained in the syringe, the gel comprising hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (BDDE), and including an amount of lidocaine.2. The device of wherein the syringe has an internal volume of about 0.4 mL to about 3 mL.3. The device of wherein the syringe has an internal volume between about 0.5 mL and about 1.5 mL.4. The device of wherein the syringe has an internal volume between about 0.8 mL and about 2.5 mL.5. The device of wherein the amount of lidocaine present in the gel is 0.3%.6. A device for restoring fat loss-related tissue volume loss in the face claim 2 , the device comprising:a syringe having an internal volume between about 0.8 mL and about 2.5 mL;a sterile viscoelastic gel contained in the syringe, the gel comprising hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (BDDE), and including 0.3% lidocaine. This application is a continuation of U.S. patent application Ser. No. 14/754,504, filed on Jun. 29, 2015, which is a continuation of U.S. patent application Ser. No. 14/242,752, filed on Apr. 1, 2014, which is a continuation of U.S. patent application Ser. No. 13/419,079, filed Mar. 13, 2012, now ...
Подробнее
