СПОСОБНЫЙ К ГИДРАТАЦИИ СОПОЛИМЕР (ВАРИАНТЫ), ОФТАЛЬМОЛОГИЧЕСКОЕ УСТРОЙСТВО, СПОСОБ ИЗГОТОВЛЕНИЯ ИНТРАОКУЛЯРНОЙ ЛИНЗЫ, СПОСОБ ИМПЛАНТАЦИИ ОФТАЛЬМОЛОГИЧЕСКОГО УСТРОЙСТВА В ГЛАЗ

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СПОСОБ ПОЛУЧЕНИЯ КОМПЛЕКСНОЙ НИТИ ИЗ ВЫСОКОКАЧЕСТВЕННОГО ПОЛИЭТИЛЕНА

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ИНТРАОКУЛЯРНАЯ ЛИНЗА

Группа изобретений относится к области интраокулярных линз. Интраокулярная линза, содержащая полимерный материал линзы, который получен из полимеризуемой композиции, содержащей: (a) один ароматический акрилатный мономер, который представляет собой акрилат, содержащий ароматическое кольцо, где указанный акрилатный мономер, содержащий ароматическое кольцо, содержит феноксигруппу, алкиленовую группу, содержащую 2 или менее атомов углерода, и акрилатный участок связывания; (b) алкоксиалкилметакрилатный мономер, содержащий алкоксиалкильную группу с 4 или менее атомами углерода; (c) алкилакрилатный мономер, содержащий алкильную группу с 1-20 атомами углерода; (d) гидрофильный мономер, где указанный гидрофильный мономер представляет собой содержащий гидроксильную группу алкилметакрилат, содержащий алкильную группу из 1-20 атомов углерода; и (e) сшиваемый мономер, где указанный сшиваемый мономер выбран из бутандиолдиакрилата, диакрилата этиленгликоля, диакрилатапропиленгликоля. При этом мольное ...

ПРОТЕЗНЫЕ УСТРОЙСТВА ИЗ ПОЛИЭТИЛЕНА СВЕРХВЫСОКОЙ МОЛЕКУЛЯРНОЙ МАССЫ, ОБРАБОТАННОГО ОБЛУЧЕНИЕМ И ПЛАВЛЕНИЕМ

Изобретение относится к ортопедии, а также к способам производства протезов. Медицинский протез предназначен для использования в виде имплантата тазобедренного и коленного суставов внутри тела и изготовлен из полиэтилена сверхвысокой молекулярной массы по существу не имеющего выявляемых свободных радикалов. Полиэтилен сверхвысокой молекулярной массы представляет собой обработанный облучением поперечно сшитый полиэтилен сверхвысокой молекулярной массы с молекулярной массой, по меньшей мере, 500000 и 2 - 3 пиками плавления. Полученные протезы проявляют сниженное образование частиц из протеза во время его ношения и, по существу, устойчивы к окислению. 13 с. и 20 з.п.ф-лы, 11 ил., 21 табл.

ГИДРОФОБНАЯ ВНУТРИГЛАЗНАЯ ЛИНЗА

Изобретение относится к внутриглазным линзам. Предложена гидрофобная внутриглазная линза (ВГЛ), содержащая по меньшей мере один сополимер, содержащий: (а) первое мономерное звено, содержащее полимеризованную метакрилатную группу и по меньшей мере одну алкоксиалкоксиалкильную боковую группу, (b) второе мономерное звено, отличное от первого мономерного звена, содержащее полимеризованную метакрилатную группу, по меньшей мере одну боковую группу, включающую (i) арилоксигруппу, содержащую по меньшей мере один галоген, и (ii) алифатический углеродный фрагмент, связывающий арилоксигруппу с полимеризованной метакрилатной группой, где алифатический углеродный фрагмент содержит по меньшей мере один гидроксильный заместитель, (c) третье мономерное звено, отличное от первого и второго мономерных звеньев, включающее полимеризованную метакрилатную группу, по меньшей мере одну боковую группу, включающую (i) арилоксигруппу, и (ii) алифатический углеродный фрагмент, связывающий арилоксигруппу с полимеризованной ...

ИМПЛАНТИРУЕМЫЙ ПОЛЫЙ ПРОТЕЗ И СПОСОБ ЕГО ИЗГОТОВЛЕНИЯ

Изобретение относится к медицине, в частности в качестве протеза во внутрисосудистой хирургии, хирургии протоков экстрасекреторных органов, хирургической онкологии, гастроэнтерологии, урологии, гинекологии, нейрохирургии и пульмонологии, а также для экстраанатомического вмешательства. Создание конструкции полого протеза (П) или составной части протеза внутреннего органа живого организма с заданной биоактивностью, замещающего структуру с соответствующей функцией или функцию, достигается за счет того, что тело (Т) протеза, состоящее как минимум из одного слоя (С), выполнено из материала (М), структура которого характеризуется двумя связанными взаимопроникающими матрицами, а именно матрицей полимера в виде узлов, соединенных фибриллами, и матрицей пространства пустот, элементы которого соединены в трехмерную сеть, причем количество узлов, фибрилл и элементов пространства пустот в единице объема непостоянно, преимущественно в виде ленты (Л), намотанной на формообразующий тело протеза сердечник ...

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Эндопротез предназначен для эндопротезирования локтевого сустава и может быть использован в травматологии и ортопедии. Эндопротез относится к локтевому суставу с элементом плечевой кости, элементу локтевой кости и элементу кости предплечья, в котором элемент локтевой кости направляется в зоне элемента плечевой кости в поворотной опоре, а элемент кости предплечья удерживается в гнезде с возможностью поворота и перемещения в области элемента локтевой кости. Элемент кости предплечья установлен с возможностью поворота в элементе скольжения, имеющем возможность, перемещения в гнезде. Технический результат заключается в улучшении сочленения между элементом кости предплечья и элементом локтевой кости в эндопротезе локтевого сустава. 28 з.п. ф-лы, 4 ил.

МАТЕРИАЛЫ ДЛЯ ОФТАЛЬМОЛОГИЧЕСКИХ И ОТОРИНОЛАРИНГОЛОГИЧЕСКИХ УСТРОЙСТВ

... 1. Полимерный материал для офтальмологических или оториноларингологических устройств, содержащий: ! а) монофункциональный акрилатный или метакрилатный мономер (1); ! b) бифункциональный акрилатный или метакрилатный сшивающий мономер (2); ! с) ароматический функциональный метакриловый или акриловый макромономер [3] с концевыми акрилатными или метакрилатными группами или ароматический функциональный метакриловый или акриловый макромономер [4] с концевыми акрилатными или метакрилатными группами ! ! ! в которых ! B = O(CH2)n, NH(CH2)n или NCH3(CH2)n; ! D = Cl, Br, H или -CH2C(=CH2)C(O)XY; ! E = H или CH3; ! G = H, C(E)(CH3)C(O)X(CH2)nH, C(E)(CH3)C(O)X(CH2CH2O)nCH3 или C(E)(CH3)C(O)X'Z'X'C(O)C(R')=CH2; ! R, R' независимо = H, CH3 или CH2CH3; ! X, X' независимо = O(CH2)n, NH(CH2)n, NCH3(CH2)n, O(CH2CH2O)nCH2, O(CH2CH2CH2O)nCH2, O(CH2CH2CH2CH2O)nCH2 или отсутствует; ! J = (CH2)a, O(CH2CH2O)b, O или отсутствует; ! n=0-6; ! Y = C6H5, (CH2)mH, (CH2)mC6H5, OH, CH2CH(OH)CH2OH, (OCH2CH2)mOCH3 или (OCH2CH2 ...

ОФТАЛЬМОЛОГИЧЕСКИЕ И ОТОЛАРИНГОЛОГИЧЕСКИЕ МАТЕРИАЛЫ СО СНИЖЕННОЙ ЛИПКОСТЬЮ ДЛЯ ПРИБОРОВ

... 1. Полимерные материалы для офтальмологических или отоларингологических приборов, содержащих ! a) главный мономер, формирующий элемент, являющийся арилакриловым гидрофобным мономером с формулой ! ! где A представляет собой H, CH3, CH2CH3 или CH2OH; ! B представляет собой (CH2)m или [O(CH2)2]n; ! C представляет собой (CH2)w; ! m представляет собой 2-6; ! n представляет собой 1-10; ! Y отсутствует, представляет собой O, S или NR, при условии, что если Y представляет собой O, S или NR, тогда (CH2)m; ! R представляет собой H, CH3, CnH2n+1 (n=1-10), изо-OC3H7, C6H5 или CH2C6H5; ! w представляет собой 0-6, при условии, что m+w ≤ 8; и ! D представляет собой H, C1-C4 алкил, С1-С4 алкокси, C6H5, CH2C6H5 или галоген, ! b) диметилакрилоксипропил-завершенный полидиметилсилоксановый макромер в количестве, достаточном для уменьшения липкости офтальмологических или отоларингологических элементов материала, в котором диметилакрилоксипропил-завершенный полидиметилсилоксановый макромер имеет формулу ! !

БИОСОВМЕСТИМЫЙ ГИДРОГЕЛЬ

Биосовместимый гидрогель предназначен для исправления косметических или функциональных дефектов (например, грудных желез, голосовых связок, пениса и т. д. путем их эндопротезирования), для создания внутритканевых депо лекарственных препаратов пролонгированного действия, для использования в качестве электропроводных иммерсионных сред и для пожизненного тампонирования каверн. Он содержит полимер на основе акриламида, полученный с использованием инициатора радикальной полимеризации в апирогенной воде в качестве дисперсионной среды. Для повышения упругости, формоустойчивости и стабильности массивных имплантатов и соответственно лечебной или косметической эффективности преимущественно при эндопротезировании гидрогель содержит поперечно сшитый полиакриламид, полученный с использованием биосовместимого сшивающего агента, преимущественно метилен-бис-акриламида, и предпочтительно с использованием в качестве инициатора полимеризации смеси персульфата аммония и тетраметилэтилендиамина. Предпочтительная ...

Способ изготовления импланта путем аддитивного избирательного лазерного спекания и имплант

КОМПОЗИЦИИ И СПОСОБЫ ИЗГОТОВЛЕНИЯ КОМПОЗИЦИЙ

... 1. Способ получения композиции по меньшей мере из двух компонентов, включающий следующие стадии: ! - обеспечение по меньшей мере одного первого, жидкого, компонента; ! - обеспечение по меньшей мере одного второго, твердого, компонента и его обработка, обеспечивающая диффузию первого компонента во второй; и ! - диффундирование первого компонента во второй. ! 2. Способ по п.1, где первый компонент включает по меньшей мере одну жидкость. ! 3. Способ по п.1 или 2, где первый компонент включает по меньшей мере один газ. ! 4. Способ по п.1, где первый компонент включает по меньшей мере одно твердое вещество, растворенное в жидкости. ! 5. Способ по п.1, где второй компонент обрабатывают таким образом, что при контактировании первого компонента со вторым создаются или усиливаются капиллярные силы. ! 6. Способ по п.1, где второй компонент является порошком, прессованным таким образом, что между частицами образуются капилляры для возникновения или усиления капиллярных сил первого компонента, контактирующего ...

МАТЕРИАЛЫ, КОТОРЫЕ СТЯГИВАЮТСЯ В ОДНОМ НАПРАВЛЕНИИ И РАСШИРЯЮТСЯ В ДРУГОМ НАПРАВЛЕНИИ

АКРИЛОВЫЕ МАТЕРИАЛЫ С ВЫСОКИМ ПОКАЗАТЕЛЕМ ПРЕЛОМЛЕНИЯ С УМЕНЬШЕННЫМ КОЛИЧЕСТВОМ ОСЛЕПЛЯЮЩИХ БЛИКОВ ДЛЯ ОФТАЛЬМОЛОГИЧЕСКИХ УСТРОЙСТВ

... 1. Полимерный материал для офтальмологических или оториноларингологических устройств, содержащийa) 50-93% полимеризуемого мономера следующей структуры:в которой: A представляет собой H или CH;B представляет собой (CH)или [O(CH)];m равно 2-6;z равно 1-10;Y отсутствует или представляет собой O, S или NR', при условии, что если Y представляет собой O, S или NR', то B представляет собой (CH);R' представляет собой H, CH, CH, изо-OCH, CHили CHCH;n'=1-10;w равно 0-6, при условии, что m+w≤8; иD представляет собой H, Cl, Br, C-Cалкил, C-Cалкокси, CHили CHCH;b) 1-5% высокомолекулярного линейного полиэтиленгликолевого компонента следующей структуры:в которой: X, X' независимо отсутствуют или представляют собой O или NH;R, R' независимо отсутствуют или представляют собой (CH);p=1-3;Q, Q' независимо отсутствуют или представляют собой C(=O)NHCHCHO;A' представляет собой H или CH;G представляет собой H, C-Cалкил, (CH)NH, (CH)COH, или R'-X'-Q'-C(=O)C(=CH)A'; иn=45-225, когда G представляет собой H, C-Cалкил ...

СПОСОБ ФОРМИРОВАНИЯ ВЯЗКИХ ГЕЛЕЙ, ПРИНИМАЮЩИХ ЗАДАННУЮ ФОРМУ, И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ МЕДИЦИНСКОГО ПРОТЕЗА

... 1. Способ формирования вязкой, принимающей заданную форму суспензии из гелевых частиц, содержащий: ! диспергирование эффективного количества сухого порошка, содержащего множество гелевых частиц, имеющих средний диаметр менее 1 мкм, где гелевые частицы содержат эффективное количество множества полимерных нитей, полученных путем полимеризации эффективного количества мономера или двух или более мономеров, по меньшей мере, один из которых выбирают из группы, состоящей из 2-алкеновой кислоты, гидрокси (2C-4C) алкил 2-алкеноата, дигидрокси (2C-4C) алкил 2-алкеноата, гидрокси (2C-4C) алкокси (2C-4C) алкил 2-алкеноата, (1C-4C) алкокси (2C-4C) алкокси (2C-4C) алкил 2-алкеноата или вицинил эпокси (1C-4C) алкил 2-алкеноата, в полярной жидкости или смеси из двух или более смешивающихся жидкостей, по меньшей мере, одна из которых является полярной, и эффективного количества сурфактанта для стабилизации множества гелевых частиц, тем самым формируя суспензию из гелевых частиц, в которой частицы концентрируют ...

Implantierbare röhrenförmige Prothese

ALKYL BORON COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE

Chirurgisches Implantat

Ein chirurgisches Implantat (1) weist eine flexible, flächige Basisstruktur (2) mit einer ersten Oberfläche (3) und einer zweiten Oberfläche (4) auf, die mit Poren (6) versehen ist, die sich von der ersten Oberfläche (3) zur zweiten Oberfläche (4) erstrecken. Eine absorbierbare Folienschicht (10) ist an der ersten Oberfläche (3) der Basisstruktur (2) platziert, ist an der Basisstruktur (2) befestigt und hat eine äußere Oberfläche (12), die von der Basisstruktur (2) weg zeigt. Ein absorbierbarer Marker (20) ist an der äußeren Oberfläche (12) der Folienschicht (10) befestigt, wobei der Marker (20) zur Anzeige einer oberseitigen/unterseitigen Orientierung der äußeren Oberfläche (12) der Folienschicht (10) und zur Anzeige eines Zentralbereichs der Basisstruktur (2) eingerichtet ist.

Die Verwendung von monomerem/polymerem Material zur Herstellung einer härtbaren Zusammensetzung für die Reparatur von Knorpeln

MESOPROTHESEUNTERLAGE.

Herstellungsverfahren eines Komposit-Prothesenlagerelements mit einer vernetzten Gelenkfläche

PARTIKEL FÜR ARZNEISTOFFABGABE

VERFAHREN UND IMPLANTIERBARER GEGENSTAND ZUR FÖRDERUNG DER ENDOTHELIALISIERUNG

Medizinische Auflage

... [Technische Aufgabe:] Die Bereitstellung einer medizinischen Auflage, die eine Fläche (einen Abschnitt) aufweist, auf die eine Ionen-Bestrahlung gerichtet war und eine Fläche (einen Abschnitt) auf die keine Ionen-Bestrahlung gerichtet war, wobei die Flächen voneinander unterschieden werden können, und ein Herstellungsverfahren für eine medizinische Auflage.[Lösung:] Wenn ein Δb-Wert sich auf die Differenz zwischen einem b1-Wert, der als b-Wert des aufgerauten Abschnitts gilt, und einem b2-Wert, der als b-Wert der zweiten Fläche (7) gilt, bezieht, weist die medizinische Auflage einen Δb-Wert im Bereich von 1,5 bis 11 auf, wobei die Eckwerte des Bereichs eingeschlossen sind. Ein Herstellungsverfahren für eine medizinische Auflage umfasst: einen Flächen-Aufrauhungsschritt auf einer gesamten oder einem Teil der ersten Fläche (5) von einer Auflage, wobei die Auflage Polytetrafluorethylen enthält, um eine aufgeraute Fläche (3) auszubilden; und einen Erwärmungsschritt, bei dem die Polytetrafluorethylen ...

Mit einem Stabilisator dotiertes Polyethylen

Die Erfindung betrifft ein Verfahren zur Herstellung eines mit einem Stabilisator, vorzugsweise Antioxidans, dotierten Polyethylens, wobei eine Polymerisation von Ethylen in Gegenwart eines Stabilisators, vorzugsweise Antioxidans, und eines Katalysators durchgeführt wird.

Prothesenausgangsmaterial, insbesondere für Dentalprothesen

Die vorliegende Erfindung betrifft ein Prothesenausgangsmaterial, enthaltend Silbersulfat. Ferner betrifft die vorliegende Erfindung ein Prothesenausgangsmaterial, insbesondere ein Prothesenausgangsmaterial für Dentalprothesen, die Verwendung dieses Prothesenausgangsmaterials für die Herstellung von Prothesen sowie insbesondere von Dentalprothesen.

Joint endoprosthesis

In a joint endoprosthesis, in particular for small joints, with a head member having an articular head and a cup member having a socket, the articular head is mounted so as to be pivotable with at least one degree of freedom in the socket. The head member can be moved in engagement with the cup member essentially transversely relative to its longitudinal axis. The head member is integrally formed and is held in the cup member, which is composed of two components, so as to be secured against withdrawal in the direction of its longitudinal axis. The two prosthetic members can be joined after a lateral deflection movement of at least one prosthetic member. A first component of the cup member having the socket is movable in engagement with a second part of the cup member after insertion of the articular head in the socket by a movement which is essentially perpendicular to the longitudinal axis of the head member. The articular head can be inserted in the socket essentially perpendicular to ...

Prosthesis for finger joints comprises a rotatable disk which is insertable in a socket and is provided on is periphery with a hole for a displaceable extension section of the distal anchoring shaft

The prosthesis for finger joints comprises a rotatable disk (8) which is insertable in a fork-like socket (3) and is provided on is periphery with a hole for a longitudinally displaceable extension section (7) of the distal anchoring shaft (5).

Expandiertes PTFE Gefässtransplantat zur Arzneimittelabgabe

POLYACRYLAMID HYDROGEL UND SEINE VERWENDUNG ALS ENDOPROTHESE

MIKROGESINTERTE EPTFE-STRUKTUR MIT KNOTEN

Hüftgelenk-Endoprothese

Hüftgelenk-Endoprothese mit einer äußeren Lagerschale aus Metall und einer darin eingesetzten Lagerpfanne aus hochmolekularem Polyethylen, die im eingesetzten Zustand an der Innenseite der Lagerschale anliegt, dadurch gekennzeichnet, daß die Lagerpfanne (3) an ihrer an der Innenseite der Lagerschale (1) anliegenden Außenseite zumindest bereichsweise mit einer dünnen Schicht (5) aus reinem Titan oder aus Titan mit Zusätzen von Kohlenstoff, Stickstoff und/oder Sauerstoff bedeckt ist. Hüftgelenk-Endoprothese nach Anspruch 1, dadurch gekennzeichnet, daß der Anteil von Kohlenstoff in der dünnen Schicht (5) von der Außenseite derselben zu dem Polyethylenmaterial hin zunimmt.

Heart valve

MICROCELLULAR FOAM TUBES

INTRAOCULAR LENS

Self-centering artificial intraocular lens

An artificial intraocular lens for surgical implantation to replace a damaged natural lens in an otherwise functional eye of a patient having a dome-shaped central disc portion (42) and haptic loops (48, 50) formed on the central portion (42), for centering the central portion (42) after implantation. The central portion (42) is composed of a dry, solid hydrophilic material capable of hydration by the natural fluid present in the eye to expand after implantation to provide an optically correct lens and in its dry state has a cross-sectional dimension substantially less than that of the natural lens. The haptic loops (48, 50) have an effective length L greater than or equal to the diameter of the capsular sac so that the lens is held in place immediately upon insertion and remains centered while the lens expands. ...

Orthopaedic polymer-on-polymer bearing

An orthopaedic prosthetic joint comprising a joint couple with a first joint component having a first bearing surface comprising a first material which comprises a first polymer, a second joint component having a second bearing surface comprising a second material which comprises a second polymer. Wherein, the first and second bearing surfaces are in sliding engagement with one another. The first polymer is harder than the second polymer and the first material includes barium sulphate. The first material maybe a polyacetal or a polyaryletherketone and the second material maybe a polyolefin, polyurethane or a polyamide.

Porous PTFE structure and process for production thereof

A porous polytetrafluoroethylene material is disclosed having a molecular microfibrous structure having, at one surface, a strong orientation in a given direction and, at another opposite surface, a strong orientation and a direction at right angles to the first, in which the orientation of the microfibrous structure progressively changes from one surface to the other. A process for preparing such an element is also disclosed.

Method of crosslinking polyolefins

CROSS-LINKED HYDROGEL COPOLYMER

... 1494641 Cross-linked hydrogel copolymer SMITH & NEPHEW RESEARCH Ltd 4 July 1975 [4 July 1974 28 April 1975] 29757/74 and 17586/75 Heading C3P A lightly cross-linked hydrogel copolymeric material capable of an uptake of physiological saline of 65-85% by weight based on the total weight of the gel is formed from (1) at least one water soluble n-vinyl lactam and (2) as a comonomer, not more than 15 mole per cent, based on the total moles of (1) and (2) of (1) and (2), of at least one compound of the formula wherein X is NH or O; R1 is H or alkyl-(C 1-4 ); and R2 is either (a) a substituted or unsubstituted aryl group or (b) an alkyl group (C 1-6 ), substituted by at least one substituted or unsubstituted aryl group and/or at least one substituted or unsubstituted aryloxy group or (c) a hydroxyalkyl group (C 1-6 ) further substituted. The specific examples describe the preparation of copolymers of (1) vinyl pyrrolidone and as (2) one of the benzyl, phenoxyethyl, phenethyl, ...

Patch for replacing a portion of bladder wall

Patch for replacing a portion of bladder wall

Patch for replacing a portion of bladder wall

VERNETZTES, ULTRA-HOCHMOLEKULARES POLYETHYLEN (UHMW-PE)

Crosslinked ultra-high molecular weight polyethylene (UHMW-PE) is disclosed, as well as molded bodies made from the UHMW-PE and a process for making such UHMWE-PE.

FIRM IMPLANT

MONOPOLAR RESTRICTIVE ONES ACETABULARTEIL

PROCEDURE FOR THE PRODUCTION OF IMPLANT PARTS FROM HIGH-INTERLACED UHMWPE

NONOXIDIZING, MEDICAL POLYMER IMPLANT

BONE CEMENT WITH IMPROVED MECHANICAL CHARACTERISTICS AND PROCEDURE FOR ITS PRODUCTION

FLEXIBLE HIP JOINT PAN AND PROCEDURE FOR THE PRODUCTION OF SUCH

DARREICHUNGSSYSTEME OF ACTIVE SUBSTANCES WITH POLY (ETHYLENE CO (METH) AKRYLATE, MEDICAL DEVICE AND PROCEDURE

MATERIALS FOR OPHTHALMI AND OTORHINOLARYNGOLOGI DEVICES

PREPREG, BONDING MATERIAL AND YOUR APPLICATIONS

POLYURETHAN-FOAM FEDERATION AS WUNDFÜLLUNG AND MANUFACTURING PROCESSES FOR IT

MATERIAL FOR CARRYING A MEDICAL IMPLANT

SYSTEM WITH LIQUIDATORS FOR A ROPE ON A COIL AND A ZERKLEINERER

CELL RELEASE STENCILS

DIFFERENTIALLY EXPANDING CONTAINER IMPLANT

ANTIBIOTIC/CANTIBIOTICS OF ABSTENTIONS PMMAKNOCHENZEMENT

MEDICAL INSTRUMENTS WITH IMPROVED ONE WIRKSTOFFREISETZUNGSPROFIL

CONTACT CONTACTS OR IN CONTACT WITH KOERPER LIQUID PRESENT ONE MEDICAL PROSTHESES

MATERIALS FOR OPHTHALMI AND OTORHINOLARYNGOLOGI DEVICES WITH ONE ALKYLPHENOLETHOXYLAT

MATERIALS FOR OPHTHALMI AND OTORHINOLARYNGOLOGI DEVICES

BIOOSMOTIC GEL FOR IMPLANTIERBARE PROSTHESES

POLYMERE ONE AND YOUR USE FOR OPTHALMI LENSES

PROCEDURE FOR THE HAERTEN OF REACTION ADHESIVES.

INTERLACED, ULTRAHIGH-MOLECULAR POLYETHYLENE (UHMW-PE)

BAENDER AND CHORD PROSTHESIS AND DEVICE FOR PRODUCTION THE SAME.

MULTIPART INTRAOCULARE LENS AND PROCEDURE FOR YOUR PRODUCTION

EYE GEL AS WELL AS PROCEDURE FOR ITS PRODUCTION.

BORON CONNECTIONS ABSTENTION STORABLE ONE, AEROB HAERTENDE PLASTIC MASSES, IN PARTICULAR REACTION ADHESIVES.

HIGH-STRENGTH AND DEGRADABLE MATERIALS AND MOLDED ARTICLES FOR THE IMPLANTATION INTO THE HUMAN AND ANIMAL ORGANISM

THE USE FROM MONOMEREM/POLYMEREM MATERIAL TO THE PRODUCTION OF A HARDENABLE COMPOSITION FOR THE REPAIR OF CARTILAGES

PROCEDURE FOR THE IMBEDDING OF LIQUID UP TO CELEBRATIONS SUBSTANCES IN (METH) ACRYLI RESINS

IN A PROCEDURE WITH NETWORKING THROUGH NACHPOLMERISATION MANUFACTURED MATERIAL FOR OPHTHALMOLOGI DEVICES WITH HIGH REFRACTIVE INDEX

PROCEDURE FOR THE IMPROVEMENT OF THE WEAR RESISTANCE OF ULTRAHIGH-MOLECULAR POLYETHYLENE

POLYMERIZE-CASH 1,2-DIPYRAZOLYLETHANE AS COLORING MATERIALS FOR OPHTHALMOLOGI PLASTIC LENSES

HYDRAULIC GELS

COMPOSITIONS OF INTERLACE-CASH PREPOLYMEREN FOR BIODEGRADABLE IMPLANTS

PROSTHESIS COMPOUND CAMP AND MANUFACTURING PROCESS

EYEBALL PROSTHESIS

HYDRAULIC GELS TO THE ORTHOPEDIC REPAIR

CONTAINER TRANSPLANT WITH IMPROVED SURFACE CURRENT

MANUFACTURING PROCESS FOR VASCULAR PROSTHESIS WITH LARGE DIAMETER AS WELL AS BY THIS PROCEDURE MANUFACTURE VASCULAR PROSTHESIS

WITH PL OXIDE INTRAOKULARE LENS COATED

UHMW POLYETHYLENE FOR IMPLANTS

POLYMERI COMPOSITIONS AND OF IT MAKING INTRA OKULARLINSEN

COATING COMPOSITION FOR INTRAOCULAREN LENSES

PROCEDURE FOR THE TREATMENT OF URINARY INCONTINENCE OF MAMMALS

PROSTHESIS FOR THE METACARPAL PHALANGEAL AND INTERPHALANGEALEN OF JOINTS IN HAND AND FOOT

Molds used to produce pva hydrogel implants and related implants

Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.

Sequentially cross-linked polyethylene

A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part.

Nanohybrid polymers for ophthalmic applications

The present invention relates to novel materials particularly useful for ophthalmic applications and methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index Materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and using the same.

Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.

Joint device and method

A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose. Further, a method of treating hip joint osteoarthritis in a human patient by providing an artificial hip joint surface using a mould is provided. The method comprises the steps of: said mould being placed inside of said hip joint, said mould being injected with a fluid adapted to harden, said fluid hardening inside of said hip joint, said mould being resorbed by the human body, and said hardened fluid serving as artificial hip joint surface.

Polymer coating comprising 2- methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization

The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerization (SI ATRP) such as ARGET SI ATRP or AGET SI ATRP and uses of said polymer coating.

Polyethylene cross-linked with an anthocyanin

A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.

Functionalizing implantable devices with a poly (diol citrate) polymer

The present invention is directed to a novel poly (diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using implantable devices coated with citric acid copolymers or citric acid copolymers impregnated with therapeutic compositions and/or cells.

Implantable polymer for bone and vascular lesions

A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

Kit and method for producing bone cement

A kit for producing bone cement includes at least one paste A and one paste B. Paste A contains at least one monomer (a1) for radical polymerization; at least one polymer (a2) insoluble in monomer (a1); at least one polymer (a3) soluble in monomer (a1); and at least one radical polymerization initiator (a4). The weight ratio of the at least one polymer (a2) to the at least one polymer (a3) is at least 2 to 1. Paste B contains at least one monomer (b1) for radical polymerization; at least one polymer (b2) and at least one accelerator (b3) soluble in monomer (b1); and optionally a polymer (b4) insoluble in monomer (b 1 ). The maximum quantity of polymer (b4) is 5% by weight, relative to the total weight of paste B. The weight ratio of polymer (b4) to the at least one polymer (b2) is no more than 0.2.

Sequentially cross-linked polyethylene

A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part.

ALLOPLASTIC INJECTABLE DERMAL FILLER AND METHODS OF USE THEREOF

A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided. In an embodiment of the method of augmenting soft tissue, the stimulation of collagen production is effected by injecting into the deep reticular dermis an a dermal filler, said dermal filler being an alloplastic injectable suspension and comprising a biocompatible and pliable material and a physiologically acceptable suspending agent. 1. A composition comprising: an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent; wherein the biocompatible and pliable material is a copolymer of phenylethyl acrylate and phenylethyl methacrylate.2. The composition of claim 1 , wherein the acrylate/methacrylate copolymer is a solid.3. The composition of claim 2 , wherein the solid selected from the group consisting of: a powder claim 2 , a non-porous microbead claim 2 , and a microsphere.4. The composition of claim 2 , wherein the solid comprises particles each having a diameter selected from the group consisting of: about 10μ to about 100μ; about 0.01μ to about 10μ claim 2 , and about 0.01μ to about 5μ.5. The composition of claim 1 , wherein the physiologically acceptable suspending agent is resorbable.6. The composition of claim 5 , wherein the physiologically ...

Ultraviolet light absorbing materials for intraocular lens and uses thereof

A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 mm Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.

THERMORESPONSIVE COMPOSITIONS FOR DERMATOLOGICAL USE AND METHODS THEREOF

The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions. 1. A liquid composition comprising a biocompatible thermoresponsive polymer , wherein the thermoresponsive polymer has a sol-gel phase transition of between about 27° C. to about 35° C. , and wherein the liquid composition does not include a therapeutic agent.2. The composition of claim 1 , wherein the biocompatible thermoresponsive polymer is a PNA-based thermoresponsive polymer.3. The composition of claim 1 , wherein the thermoresponsive polymer is a PVCL-based thermoresponsive polymer claim 1 , a PMVE-based thermoresponsive polymer claim 1 , a PEOVE-based thermoresponsive polymer claim 1 , a PNVIBAm-based thermoresponsive polymer claim 1 , a PNVBAm-based thermoresponsive polymer claim 1 , or a PVEE-based thermoresponsive polymer.4. The composition of claim 1 , wherein the thermoresponsive polymer is a PEO/PPO-based thermoresponsive polymer.5. The composition of claim 4 , wherein the PEO/PPO-based thermoresponsive polymer is a PEO/PPO-based homopolymer claim 4 , a PEO/PPO-based copolymer claim 4 , a PEO/PPO-based block copolymer or a PEO/PPO-based interpenetrating network copolymer.6. The composition of claim 1 , wherein the thermoresponsive polymer is a PEG-based thermoresponsive polymer.7. The composition of claim 1 , wherein the PEG-based thermoresponsive polymer is a PEG-based homopolymer claim 1 , a PEG-based copolymer claim 1 , a PEG-based block copolymer or a PEG-based interpenetrating network copolymer.8. The composition of claim 6 , wherein the PEG-based thermoresponsive polymer is a PEG/polyester-based thermoresponsive polymer.9. The composition of claim 1 , wherein the liquid composition further comprises an anesthetic agent.10. A method of treating a soft tissue or skin condition in an individual in need thereof claim 1 , the method comprising the step of administering a liquid ...

Refractive-diffractive ophthalmic device and compositions useful for producing same

A multifocal ophthalmic device is disclosed, wherein the lens body comprises a curcuminoid compound as a UV-light stabilizer, and/or a co-polymeric composition which is derived from a pre-polymerization mixture of defined monomers The lens body of the multifocal ophthalmic device is being formed with a plurality of concentric annular zones, which effect both diffraction and refraction of incident light, and which are separated by slanted steps that are substantially devoid of any diffractive or refractive power.

Medical devices having improved performance

In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block.

Optical material and method for modifying the refractive index

An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Coatings for drug delivery devices

A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

Patellar implants

A patellar implant is provided being of a two part construction having a strong base portion 32, 54, 72 and 92 (manufactured from a metal material or other medical grade strong material) with a molder outer material 34, 62, 80 and 100 (manufactured from a polymeric material or other softer, smoother material) at least on one side to provide a smooth friction surface to contact the femoral portion of a patient's knee.

Stimuli Responsive Nanofibers

A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.

Polymers for intraocular lenses

The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.

Polymers and methods for ophthalmic applications

The present invention relates to novel methods and materials particularly useful for ophthalmic applications and to methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and implanting IOLs made therefrom.

Surgical polymer molded and flexible covering material with or without secondary composite additive materials for providing anti-bacterial and tear resistant properties

A surgically implantable mesh for covering a tear or rupture in a lining associated with an interior body cavity. A mat shaped polymer body has top and bottom spaced apart surfaces which are communicable at intervals by an interior configuration defined in the body and which promotes tissue in-growth following implantation. An antibacterial additive is intermixed with the polymer in a viscous state prior to formation and can included at least one of silver, gold, copper, bronze, or ground bamboo fibers.

PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL

A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell. 1. A water-soluble photo-activatable polymer comprising:(a) a photo-activatable group, wherein the photo-activatable group is adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon;(b) a reactive group, wherein the reactive group is adapted to covalently react with a biomaterial;(c) a hydrophilic group, wherein the hydrophilic group is present in an amount sufficient to make the water-soluble photo-activatable polymer soluble in water; and(d) a polymer precursor.2. The water-soluble photo-activatable polymer of claim 1 , wherein the polymer precursor comprises at least one monomer selected from the group consisting of allylamine claim 1 , vinylamine claim 1 , acrylic acid claim 1 , carboxylic acid claim 1 , alcohol claim 1 , ethylene oxide claim 1 , and acyl hydrazine.3. The water-soluble photo-activatable polymer of claim 1 , wherein the reactive group is a member selected from ...

Antibacterial calcium-based materials

A preparation at least useful as a bone implant is provided, which contains a solid component including a lithium compound and a calcium compound. The preparation shows an anti-bacterial ability in comparison with a preparation contains the calcium compound but free of the lithium compound. 1. An anti-bacterial preparation comprising a solid component comprising a lithium compound and a calcium compound.2. The preparation of which shows an improved anti-bacterial ability in comparison with a preparation containing the calcium compound but free of the lithium compound.3. The preparation of wherein a Hanks' solution with the anti-bacterial preparation immersed therein in a ratio of solution:anti-bacterial preparation=10 cc/g exhibits a pH value of not less 10.4. The preparation of wherein the anti-bacterial preparation contains 5-80% of the lithium compound claim 1 , based on the weight of the solid component.5. The preparation of wherein the lithium compound is a lithium salt claim 1 , lithium oxide claim 1 , lithium amide (LiNH) claim 1 , lithium hydroxide or lithium halide.6. The preparation of wherein the lithium compound is lithium carbonate claim 1 , lithium sulfate claim 1 , lithium phosphate claim 1 , lithium oxide claim 1 , lithium fluoride claim 1 , lithium acetate claim 1 , lithium bromide claim 1 , lithium hydroxide claim 1 , lithium nitrate claim 1 , lithium nitrite claim 1 , lithium iodide claim 1 , lithium molybdate (LiMoO) claim 1 , lithium tetraborate (LiBO) claim 1 , lithium citrate tetrahydrate (LiCHO.4HO) claim 1 , or lithium stearate (LiCHO).7. The preparation of wherein the lithium compound is lithium carbonate claim 1 , or lithium phosphate.8. The preparation of wherein the solid component is a powder component comprising the lithium compound and the calcium compound claim 1 , wherein the calcium compound is selected from the group consisting of a calcium phosphate claim 1 , calcium sulfate claim 1 , calcium oxide claim 1 , calcium carbonate ...

CROSSLINKED POLYMERS INCLUDING ONE OR MORE ANTIOXIDANTS, METHODS FOR MAKING SAME AND METHODS FOR SELECTING ANTIOXIDANTS

The present disclosure is directed to polymer compositions having one or more antioxidants providing high crosslink density and improved oxidation resistance to the polymer composition and methods for making same. Such polymer compositions can be advantageously used to make orthopedic implants. The disclosure also provides methods for selecting antioxidants providing desirable properties to the polymer composition. In one embodiment, a measure of OIT can be used to select the antioxidant and antioxidant blend. In another embodiment, measurements of OIT and OI-rate can be used to select the one or more antioxidants. In an other embodiment, the product of OIT and crosslink density can be calculated to predict wear resistance and oxidation resistance of a polymer composition including one or more antioxidants. 1. An orthopedic implant comprising: a homogeneous blend of UHMWPE resin,', 'a first antioxidant comprising a primary antioxidant, and', 'a second antioxidant comprising a secondary antioxidant;, 'a consolidated and crosslinked UHMWPE blend, the UHMWPE blend comprisingwherein a combined concentration of the first and second antioxidants prior to crosslinking is from about 0.05% to about 5% by weight of the UHMWPE blend.246.-. (canceled)47. The orthopedic implant of claim 1 , wherein the consolidated and crosslinked UHMWPE blend has a crosslink density claim 1 , an oxidation index rate claim 1 , and an oxidation induction time measure by the offset method claim 1 , and the product of the crosslink density and oxidation induction time is greater than 1.5.48. The orthopedic implant of claim 1 , wherein the product of the crosslink density and the inverse of the oxidation index rate of the consolidated and crosslinked UHMWPE blend is greater than 2500.49. The orthopedic implant of claim 1 , wherein the consolidated and crosslinked UHMWPE blend has an oxidation induction time as measured by the offset method of greater than 15 minutes.50. The orthopedic implant of ...

MODIFIED POLYMERIC MATERIALS AND METHODS OF MODIFYING POLYMERIC MATERIALS

Methods of forming polymeric articles using plasma treated polymer resins, and orthopedic implants comprising a polymeric article wherein the polymeric article has reactive groups bonded to polymer molecules in an interior region of the polymeric article. 1. A method of forming a polymeric article suitable for use as an orthopedic implant , the method comprising:providing or receiving particles of a polymer resin;exposing the particles of the polymer resin to a plasma, the plasma reacting with the particles of the polymer resin to bond one or more selected reactive groups to the particles; andmolding a polymeric article from the polymer resin after exposing the polymer resin to the plasma.2. The method of claim 1 , wherein the plasma is formed from a gas selected from the group consisting of nitric oxide claim 1 , carbon dioxide claim 1 , ammonia claim 1 , amino monomer claim 1 , and combinations thereof.3. The method of claim 1 , wherein the one or more selected reactive groups are selected from the group consisting of amines claim 1 , amides claim 1 , imides claim 1 , carboxyl claim 1 , carbonyl claim 1 , hydroxyl claim 1 , sulfonates claim 1 , phosphates claim 1 , perfluoro and combinations thereof.4. The method of claim 1 , further comprising blending the particles of the first polymer resin with an additive.5. The method of claim 4 , wherein the additive is an antioxidant or biological agent.6. The method of claim 4 , wherein the blending occurs after exposure of the particles to the first plasma.7. The method of claim 1 , wherein molding comprises compression molding the polymer resin.8. The method of claim 1 , wherein the polymer resin is selected from the group consisting of as polyethylene claim 1 , ultrahigh molecular weight polyethylene claim 1 , polyaryletherketones claim 1 , polypropylene claim 1 , polyurethanes claim 1 , acrylics claim 1 , polyethylene-co-vinyl alcohol claim 1 , nylon claim 1 , polysulfones claim 1 , polycarbonates claim 1 , and ...

DEGRADABLE THIOL-ENE POLYMERS

A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins. 1. A method for producing a biocompatible cross-linked degradable thiol-ene hydrogel polymer comprising subjecting a polymerization reaction mixture comprising a thiol compound and an olefin compound to a radical polymerization reaction under conditions sufficient to produce a biocompatible cross-linked degradable thiol-ene hydrogel polymer , wherein the thiol compound comprises m number of reactive thiol groups , and the olefin compound comprises n number of reactive ene groups , and wherein each of n and m is an integer of at least 2 , provided the sum of n+m is at least 5.2. The method of claim 1 , wherein the thiol compound comprises a polymeric moiety selected from the group consisting of poly(lactic acid) (PLA); polyglycolide (PGA); a copolymer of PLA and PGA (PLGA); poly(vinyl alcohol) (PVA); poly(ethylene glycol) (PEG); poly(ethylene oxide); a poly(ethylene oxide)-co-poly(propylene oxide) block copolymer; a poloxarnine; a polyanhydride; a polyorthoester; a poly(hydroxy acids); a polydioxanone; a polycarbonate; a polyaminocarbonate; a poly(vinyl pyrrolidone); a poly(ethyl oxazoline); a carboxymethyl cellulose; a hydroxyalkylated cellulose; a polypeptide; a polysaccharide; a carbohydrate; heparan sulfate; chondroitin sulfate; heparin claim 1 , alginate; and a combination thereof.3. The method of claim 2 , wherein the thiol compound comprises a polymeric moiety selected from the group consisting of polypeptide claim 2 , poly(lactic acid) (PLA) claim 2 , poly(vinyl alcohol) (PVA) claim 2 , and poly(ethylene glycol) (PEG) claim 2 , and a combination thereof.4. The method of claim 1 , wherein the ene compound comprises a polymeric moiety ...

Hppe member and method of making a hppe member

The invention concerns a high performance polyethylene (HPPE) member comprising at least 5 wt-% of a radiopaque component, the HPPE member is biocompatible and the radiopaque component is a particulate at least partially arranged inside a HPPE filament of the HPPE member. Furthermore, the radiopaque component has a particle size of at most 1 μm, preferably the radiopaque component has a particle size if at most 0.5 μm. The invention also concerns a method of making the HPPE member and various medical devices and repair products comprising the HPPE member.

METHODS FOR MAKING OXIDATION-RESISTANT CROSS-LINKED POLYMERIC MATERIALS

The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided. 199-. (canceled)100. A method of making an oxidation-resistant cross-linked polymeric material comprising the steps of:a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant, a second portion of the polymeric material is contacted with another concentration of the antioxidant, and a third portion of the polymeric material is contacted with another concentration of the antioxidant;b) consolidating the antioxidant-blended polymeric material by layering the third portion of the polymeric material, the second portion of the polymeric material, and the first portion of the polymeric material, thereby forming an antioxidant-blended consolidated polymeric material; andc) irradiating the antioxidant-blended consolidated polymeric material with ionizing radiation, thereby forming an oxidation-resistant cross-linked consolidated polymeric material.101. A method of making a medical implant preform comprising an oxidation-resistant cross-linked polymeric material , wherein the method comprising the steps of:a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant, a second portion of the polymeric material is contacted with another concentration of the antioxidant, and a third portion of the ...

JACKET FOR SURGICAL HEART VALVE

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a prosthetic valve. The prosthetic valve may include a jacket configured to cover at least one of gaps, spaces, or interfaces in a frame or between one or more leaflets attached to the frame. 1. A jacket for a prosthetic valve including an inflow side and an outflow side , the jacket comprising:a first portion operable to be coupled to the outflow side of the prosthetic valve, the first portion having a first height; anda second portion operable to be coupled to the inflow side of the prosthetic valve, the second portion having a second height,wherein the first portion and the second portion are operable to be coupled together for form a protective covering around the prosthetic heart valve.2. The jacket of claim 1 , wherein the first and the second portions are operable to be secured together by at least one of a swaging claim 1 , a snap fit claim 1 , a click fit claim 1 , one or more staples claim 1 , tape claim 1 , adhesives claim 1 , one or more screws claim 1 , one or more rivets claim 1 , insert molding claim 1 , or overmolding.3. The jacket of claim 1 , wherein the first portion and the second portion are operable to be secured together about a frame of the prosthetic valve.4. The jacket of claim 3 , wherein the first and second portions are operable to interface between a sewing cuff and the frame of the prosthetic valve.5. The jacket of claim 1 , wherein the first portion includes a post cover portion operable to cover a commissure post of the prosthetic valve.6. The jacket of claim 5 , wherein the post cover portion is atraumatic.7. The jacket of claim 1 , wherein the first portion includes first interfaces and the second portion includes second interfaces claim 1 , the first and second interfaces being configured to join the first and second portions together.8. The jacket of claim 7 , wherein the first and second interfaces form a post cover ...

Migration-Resistant Gastrointestinal Barrier

A prosthesis and a method for securing a prosthesis at a treatment site are provided. The prosthesis includes a material portion. The material portion includes a liquid-impermeable material layer, a porous material layer having a pore size adapted for promoting tissue ingrowth, and an adhesive portion provided on the porous material layer adapted to secure the material portion to a site for at least 24 hours following implantation of the prosthesis at the site. In some embodiments, the prosthesis further includes a body. 1. A migration resistant prosthesis , the prosthesis comprising: a liquid-impermeable material layer;', 'a porous material layer having a pore size adapted for promoting tissue ingrowth; and', {'b': '24', 'an adhesive portion provided on the porous material layer adapted to secure the material portion to a site for at least hours following implantation of the prosthesis at the site.'}], 'a material portion, the material portion comprising2. The migration resistant prosthesis according to claim 1 , further comprising a body having a proximal portion claim 1 , a distal portion and a lumen extending therethrough claim 1 , at least a portion of the body providing a force adapted to expand the body radially outward in a final position of the prosthesis claim 1 , the body further comprising a porous portion adapted for tissue ingrowth claim 1 , the material portion operably connected to the body and extending distally from the body.3. The prosthesis according to claim 1 , wherein the body comprises a metal claim 1 , a polymer or a composite.4. The prosthesis according to claim 1 , wherein the porous portion covers a portion of the body.5. The prosthesis according to claim 1 , wherein the material portion overlaps a portion of the body.6. The prosthesis according to claim 1 , wherein the material portion further comprises a porous layer.7. The prosthesis according to claim 1 , wherein the material portion comprises a non-porous material.8. The prosthesis ...

Uniaxially-aligned nanofiber scaffolds and methods for producing and using same

Oral cavity wound healing occurs in an environment that sustains ongoing physical trauma and is rich in bacteria. Patients undergoing cleft palate repair have a high degree of wound healing complications, such as oronasal fistula (ONF) formation. Following hard palate injury, ONF was created that demonstrated little change in pro-regenerative monocytes LY6Clo monocytes; however, there were increased M2 macrophages observed. Delivery of FTY720 nanofiber scaffolds following hard palate injury prevented ONF formation, allowed complete wound healing and was associated with increased LY6Clo monocytes and pro-regenerative M2 macrophages. Evaluation of interleukin gene expression revealed reduction in pro-inflammatory IL1 and IL6 and increased expression of pro-regenerative IL10 with FTY720 nanofiber delivery. The ability of FTY720 scaffolds to increase LY6Clo monocytes, increase M2 macrophages and alter the interleukin expression during hard palate mucosal healing demonstrates the ability of a FTY720-based autotherapy to improve oral cavity wound healing.

INTERPENETRATING NETWORKS WITH COVALENT AND IONIC CROSSLINKS

The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer. 136.-. (canceled)37. An interpenetrating networks hydrogel comprising a first network and a second network , wherein:the first network comprises a covalently crosslinked polymer selected from the group consisting of polyacrylamide, poly(vinyl alcohol), poly(ethylene oxide) and its copolymers, polyethylene glycol (PEG), methacrylated PEG, and polyphosphazene; andthe second network comprises an ionically crosslinked polymer selected from the group consisting of alginate, chitosan, and agarose; andthe covalently crosslinked polymer has a crosslinking density that is derived from a weight ratio between a covalent crosslinking agent and a monomer of the covalently crosslinked polymer of between about 0.031 wt. % and 0.124 wt. % based on the monomer weight.38. The hydrogel of claim 37 , wherein the first network and the second network are covalently coupled.39. The hydrogel of claim 37 , wherein the first network comprises polyacrylamide or polyethylene glycol (PEG) and wherein the second network comprises alginate.40. The hydrogel of claim 37 , wherein the covalent crosslinking agent is selected from the group consisting of N claim 37 ,N-methylenebisacrylamide (MBAA) claim 37 , a methacrylate crosslinker claim 37 , N claim 37 ,N′-dicyclohexylcarbodiimide (DCC) claim 37 , 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (ECC) claim 37 , N-hydroxysuccinimide claim 37 , N-hydroxysulfosuccinimide claim 37 , glutaraldehyde claim 37 , and a transglutaminase.41. The hydrogel of claim 37 , wherein the covalently crosslinked polymer has a crosslinking density that is derived from a weight ratio between a covalent ...

BIODEGRADABLE SCAFFOLDS

In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects. Further embodiments of the present invention pertain to methods of making the compositions of the present invention. 1. A method of making a drug delivery composition , comprising dispersing in a biodegradable polymer matrix (a) at least one biodegradable reinforcing particle selected from the group consisting of porous oxide particles and porous semiconductor particles; and (b) a population of hydrogel porogen particles that comprises at least one active agent.2. The method of claim 1 , wherein the at least one active agent is selected from the group consisting of therapeutics claim 1 , imaging agents claim 1 , anti-inflammatory agents claim 1 , antibiotics claim 1 , proteins claim 1 , platelet rich plasma claim 1 , cells claim 1 , degradation inducers of porous particles claim 1 , and combinations thereof.3. The method of claim 2 , wherein the at least one active agent is a therapeutic agent.4. The method of claim 1 , wherein the biodegradable polymer matrix comprises an unsaturated biodegradable polymer.5. The method of claim 4 , wherein the ...

Hydrophobic compounds for optically active devices

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

Ultra-High Molecular Weight Ethylene-Based Copolymer Powder, and Molded Article Using Ultra-High Molecular Weight Ethylene-Based Copolymer Powder

An ultra-high molecular weight ethylene-based copolymer powder comprising: an ethylene unit and an α-olefin unit having 3 or more and 8 or less carbon atoms as structural units, wherein the ultra-high molecular weight ethylene-based copolymer powder has a viscosity-average molecular weight of 100,000 or more and 10,000,000 or less, a content of the α-olefin unit is 0.01 mol % or more and 0.10 mol % or less based on a total amount of the ethylene unit and the α-olefin unit, and in measurement with a differential scanning calorimeter under following conditions,an isothermal crystallization time is determined as a time from reaching 126° C. of Step A3 as a starting point (0 min) to giving an exothermic peak top due to crystallization and the isothermal crystallization time is 5 minutes or more. (Conditions for measurement of isothermal crystallization time) Step A1: holding at 50° C. for 1 minute and then an increase up to 180° C. at a temperature rise rate of 10° C./min, Step A2: holding at 180° C. for 30 minutes and then a decrease down to 126° C. at a temperature drop rate of 80° C./min, and Step A3: holding at 126° C.

PLASMA-ASSISTED FLEXIBLE MULTI-SCALE TOPOGRAPHIC PATCHES FOR ENGINEERING CELLULAR BEHAVIOR AND TISSUE REGENRATION

The present invention provides a scaffold for tissue regeneration and a method of manufacturing the same. The scaffold for tissue regeneration of the present invention includes grooves and ridges formed on one surface thereof, wherein the grooves or ridges have a plurality of nanopores formed thereon, thereby providing an environment suitable for attachment, differentiation, growth, and migration of cells. Therefore, the scaffold may be effectively used as a material for tissue regeneration. 1. A scaffold for tissue regeneration comprising:a plurality of grooves and ridges on one surface thereof,wherein the grooves or ridges have a plurality of nanopores formed thereon.2. The scaffold according to claim 1 , wherein the grooves and the ridges extend in one direction.3. The scaffold according to claim 1 , wherein the grooves and the ridges have a width of 100 to 900 nm claim 1 , respectively.4. The scaffold according to claim 1 , wherein a ratio of widths of the grooves and the ridges is 1:0.5 to 1.5.5. The scaffold according to claim 1 , wherein the ridge has a height of 100 to 900 nm from the groove.6. The scaffold according to claim 1 , wherein the nanopore has a diameter of 50 to 200 nm.7. The scaffold according to claim 1 , wherein the one surface has a carboxyl group (O═C—O) claim 1 , a carbonyl group (C═O) claim 1 , or a hydroxyl group (—OH).8. The scaffold according to claim 1 , wherein the scaffold is made of one or more materials selected from the group consisting of polyurethane acrylate (PUA) resin claim 1 , polyvinyl alcohol resin claim 1 , polyethylene resin claim 1 , polypropylene resin claim 1 , polyethylene glycol resin claim 1 , poly(L-lactide-co-glycolide) resin claim 1 , polycaprolactone (PCL) resin claim 1 , polylactic acid (PLA) resin claim 1 , polyglycolic acid (PGA) resin claim 1 , chitosan claim 1 , gelatin claim 1 , collagen claim 1 , and a combination thereof.9. The scaffold according to claim 1 , wherein the tissue is epithelial tissue ...

PROCESS MONITORING AND CONTROL DURING LASER-BASED REFRACTIVE INDEX MODIFICATION OF INTRAOCULAR LENSES IN PATIENTS

Methods and related apparatus for real-time process monitoring during laser-based refractive index modification of an intraocular lens. During in situ laser treatment of the IOL to modify the refractive index of the IOL material, a signal from the IOL is measured to determine the processing effect of the refractive index modification, and based on the determination, to adjust the laser system parameters to achieve intended processing result. The signal measured from the IOL may be a fluorescent signal induced by the treatment laser, a fluorescent signal induced by an external illumination source, a temporary photodarkening effect, a color change, or a refractive index change directly measured by phase stabilized OCT. 1. A method for real-time process monitoring during laser-based refractive index modification of an intraocular lens (IOL) , comprising:treating the IOL with a laser beam to modify a refractive index of the IOL at selected locations;while treating the IOL with the laser beam, measuring a signal from the IOL to determine a processing effect of refractive index modification of the IOL; andbased on the determination, further treating the IOL with the laser beam.2. The method of claim 1 , wherein the signal measured from the IOL is a fluorescent signal induced by the treatment laser beam.3. The method of claim 1 , further comprises illuminating the IOL with an external illumination source claim 1 , wherein the signal measured from the IOL is a fluorescent signal induced by the external illumination source.4. The method of claim 1 , further comprises illuminating the IOL with a light source claim 1 , wherein the signal measured from the IOL is a temporary photodarkening effect.5. The method of claim 1 , further comprises illuminating the IOL with a broadband visible light source claim 1 , wherein the signal measured from the IOL is a color change.6. The method of claim 1 , wherein measuring the signal from the IOL includes measuring a refractive index change ...

OXIDATION-RESISTANT AND WEAR-RESISTANT POLYETHYLENES FOR HUMAN JOINT REPLACEMENTS AND METHODS FOR MAKING THEM

The present invention presents methods for making oxidation-resistant and wear-resistant polyethylenes and medical implants made therefrom. Preferably, the implants are components of prosthetic joints, e.g., a bearing component of an artificial hip or knee joint. The resulting oxidation-resistant and wear-resistant polyethylenes and implants are also disclosed. 1. (canceled)2. A method for producing a wear-resistant and oxidation-resistant medical implant for a joint prosthesis comprising:providing an oxidation-resistant orthopaedic material comprising a polyethylene;forming the orthopaedic material into an implant for the joint prosthesis;packaging the orthopaedic material after being formed into the implant;sterilizing the orthopaedic material while packaged; andirradiating the orthopaedic material during the method at a total radiation dose of above 5 Mrad to about 25 Mrad so as to crosslink the orthopaedic material, thereby improving its wear resistance, without thermally treating the orthopaedic material to extinguish free radicals in the orthopaedic material during or subsequent to irradiating the orthopaedic material, wherein the orthopaedic material contains an antioxidant rendering it resistant to oxidation caused by free radicals generated by the irradiation.3. The method of claim 2 , wherein the irradiated orthopaedic material possesses a degree of swelling of between about 1.7 to about 3.6.4. The method of claim 2 , wherein the irradiated orthopaedic material possesses a molecular weight between crosslinks of between about 400 to about 3 claim 2 ,500 g/mol.5. The method of claim 2 , wherein the irradiated orthopaedic material possesses a gel content of between about 95% to about 99%.6. The method of claim 2 , wherein the irradiated orthopaedic material possesses a degree of swelling of between about 1.7 to about 3.6 claim 2 , and a molecular weight between crosslinks of between about 400 to about 3 claim 2 ,500 g/mol.7. The method of claim 2 , wherein ...

HIGH-PERFORMANCE POLYETHYLENE MULTIFILAMENT YARN

Processes for making high-performance polyethylene multi-filament yarn are disclosed which include the steps of a) making a solution of ultra-high molar mass polyethylene in a solvent; b) spinning of the solution through a spinplate containing at least 5 spinholes into an air-gap to form fluid filaments, while applying a draw ratio DR; c) cooling the fluid filaments to form solvent-containing gel filaments; d) removing at least partly the solvent from the filaments; and e) drawing the filaments in at least one step before, during and/or after said solvent removing, while applying a draw ratio DRof at least 4, wherein in step b) each spinhole comprises a contraction zone of specific dimension and a downstream zone of diameter Dn and length Dn with Ln/Dn of from 0 to at most 25, to result in a draw ratio DR=DR*DRof at least 150, wherein DRis the draw ratio in the spinholes and DRis the draw ratio in the air-gap, with DRbeing greater than 1 and DRat least 1. High-performance polyethylene multifilament yarn, and semi-finished or end-use products containing said yarn, especially to ropes and ballistic-resistant composites, are also disclosed. 1. A preformed sheet comprising four mono-layers , each mono-layer comprising filaments from multifilament polyethylene yarn , the polyethylene having an IV of between 8 and 40 dl/g as measured on decalin solutions at 135° C. , wherein said filaments in said mono-layers are spread uni-directionally; and wherein the direction of the filaments in each mono-layer is rotated with respect to the direction of the filaments in an adjacent layer , and wherein the preformed sheet exhibits a specific energy absorption of more than 265 and at most 479 J·kg/magainst a 9*19 mm FMJ Parabellum FMJ bullet , as measured on panels assembled from a plurality of the preformed sheets having an areal density of 2.0 kg/m.2. The preformed sheet of claim 1 , wherein the preformed sheet exhibits a specific energy absorption of between 280 and 479 J·kg/ ...

PHOTO-REACTIVE INKS AND THERMAL-CURABLE MATERIALS MADE THEREFROM

Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof. 1. A composition comprising:(a) an acrylated or methacrylated polymer;(b) a photoinitiator, wherein exposure to light of an appropriate wavelength results in formation of a first reactive species from the photoinitiator compound; and(c) a thermal initiator, wherein exposure to heat results in in formation of a second reactive species from the thermal initiator compound.2. The composition of claim 1 , wherein the first reactive species and/or second reactive species is a free radical.3. The composition of claim 1 , wherein the appropriate wavelength of light is in the UV range.4. The composition of claim 1 , wherein exposure to heat comprises increasing temperature above a threshold temperature.5. The composition of claim 1 , further comprising one or more additional polymeric claim 1 , bioceramic claim 1 , or nanostructured components.6. The composition of claim 5 , wherein the acrylated or methacrylated polymer and the additional component are present at a ratio of between 1:10 and 10:1.7. The composition of claim 5 , wherein the additional component is hydroxyapatite.8. The composition of claim 5 , wherein the additional component is tricalcium phosphate (TCP).9. The composition of claim 5 , wherein the additional component is a metal organic framework (MOF).10. The composition of claim 9 , wherein the MOF is a copper (Cu) MOF.11. The composition of claim 1 , further comprising a bioceramic and an MOF.12. The composition of claim 11 , wherein the bioceramic is TCP and the MOF is a Cu MOF.13. The composition of claim 1 , further comprising a solvent.14. The composition of claim 1 , wherein the composition is a liquid.15. The composition of claim 14 , wherein the composition is an ink suitable for photoinitiated 3D printing.16. The composition of claim 15 , wherein exposure of the ...

MEDICAL IMPLANT COMPONENT COMPRISING A COMPOSITE BIOTEXTILE AND METHOD OF MAKING

Disclosed herein is a medical implant component comprising a composite biotextile, which biotextile comprises i) a polyolefin fibrous construct comprising at least one strand with titer of 2-250 dtex, tensile strength of at least 10 cN/dtex and comprising high molar mass polyolefin fibers and ii) a coating comprising a biocompatible and biostable polyurethane elastomer comprising a polysiloxane segment and/or having one or more hydrophobic endgroups, wherein the polyurethane coating is present on at least part of the surface of the biotextile and in an amount of 2.5-90 mass % based on composite biotextile. Such composite biotextile, like a partly coated woven fabric, shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and laser cuttability; allowing to make pieces of fabric having well-defined regular edges that have high suture retention strength. The invention also provides a method of making said composite biotextile. Further embodiments concern the use of such biotextile in or as medical implant component for an implantable medical device and the use of such medical implant component in making an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said medical implant component. 2. (canceled)3. The medical implant component according to claim 1 , wherein the fibrous construct has anisotropic properties claim 1 , which anisotropy results from a combination of at least two different strands in the fibrous construct claim 1 , and/or from a combination of at least two of a rope claim 1 , a cable claim 1 , a tape claim 1 , and a textile in the fibrous construct.4. The medical implant component according to claim 1 , wherein the at least one strand has a titer of 4-140 dtex.5. The medical implant component according to claim 1 , wherein the polyolefin fibrous construct has a thickness of about ...

COAXIAL NEEDLE FOR FABRICATING A MULTI SCALE, MULTI LAYER BLOOD VESSEL OR VASCULAR NETWORK EMPLOYING 3D BIOPRINTING

A coaxial needle having two or more passageways for forming a biomimetic bioprinted blood vessel tubular construct. The coaxial needle has an external needle passageway and an internal needle passageway separated by an internal barrier, and having a nozzle at an end thereof. A bioink is provided flowable through the external needle passageway and a crosslinking solution is provided flowable through the internal needle passageway. The crosslinking solution contacts the bioink as the crosslinking solution and bioink exit the nozzle thereby forming a tubular blood vessel construct. 1. A method of forming a biomimetic blood vessel comprising:flowing a bioink through an external needle passageway of a coaxial needle and out through a nozzle of the coaxial needle, the nozzle being at one end of the coaxial needle;flowing a crosslinking solution through an internal needle passageway of the coaxial needle and out through the nozzle of the coaxial needle, the external needle passageway and internal needle passageway being separated by a barrier; andcontacting the crosslinking solution with the bioink as the crosslinking solution and the bioink exit the nozzle thereby forming a tubular blood vessel construct.2. The method of wherein the bioink comprises a gelatin methacrylate functionalized with a crosslinkable group.3. The method of claim 2 , wherein the gelatin methacrylate is functionalized with a catechol.4. The method of claim 1 , wherein the bioink is cell-laden.5. The method of claim 4 , wherein the bioink is cell-laden with smooth muscle cells.6. The method of claim 1 , wherein the crosslinking solution comprises a crosslinking agent.7. The method of claim 6 , wherein the crosslinking agent is an oxidant.8. The method of claim 7 , wherein the oxidant is a periodate salt or a derivative thereof.9. The method of claim 1 , wherein the crosslinking solution comprises a removable fugitive ink.10. The method of claim 9 , wherein the fugitive ink comprises a block copolymer ...

ELECTRICALLY ACTIVE HYDROPHILIC BIO-POLYMERS

A process of forming a cross-linked electronically active hydrophilic co-polymer comprising the steps of: providing a co-monomer solution comprising at least one hydrophobic monomer, at least one hydrophilic monomer, water, at least one amino acid and at least one cross-linker; and polymerising the co-monomer solution. 1. A process of forming a cross-linked electronically active hydrophilic co-polymer comprising the steps of:providing a co-monomer solution comprising at least one hydrophobic monomer, at least one hydrophilic monomer, water, at least one amino acid and at least one cross-linker; andpolymerising the co-monomer solution.2. The process according to claim 1 , wherein the at least one amino acid is selected from phenylalanine claim 1 , tryptophan claim 1 , histidine claim 1 , ethylenediaminetetraacetic acid (EDTA) and tyrosine claim 1 , or a combination thereof.3. The process according to claim 2 , wherein the at least one amino acid is selected from phenylalanine and tryptophan claim 2 , or a combination thereof.4. The process according to claim 1 , wherein the at least one hydrophilic monomer is selected from methacrylic acid claim 1 , 2-hydroxyethyl methacrylate claim 1 , ethyl acrylate claim 1 , vinyl pyrrolidone claim 1 , propenoic acid methyl ester claim 1 , monomethacryloyloxyethyl phthalate claim 1 , ammonium sulphatoethyl methacrylate claim 1 , poly vinyl alcohol or a combination thereof.5. The process according to claim 4 , wherein the at least one hydrophilic monomer is selected from vinyl pyrrolidone and hydroxyethyl methacrylate claim 4 , or a combination thereof.6. The process according to claim 1 , wherein the at least one hydrophobic monomer is selected from methyl methacrylate claim 1 , allyl methacrylate claim 1 , acrylonitrile claim 1 , methacryloxypropyltris(trimethylsiloxy)silane claim 1 , 2 claim 1 ,2 claim 1 ,2-trifluoroethyl methacrylate claim 1 , or a combination thereof.7. The process according to claim 6 , wherein the at least ...

Artificial dermis repair material and preparation method therefor

An artificial dermis repair material and a preparation method therefor. The artificial dermis repair material comprises a silicon rubber layer and a collagen complex layer adhered to each other; the collagen complex layer is prepared from raw materials comprising collagen, a mucopolysaccharide, and an antibacterial agent, which undergo a crosslinking reaction. The silicon rubber layer has high strength, high elasticity and softness, is easy to stitch, and has a good fitting performance; the collagen complex layer has good biocompatibility, degradability and an antibacterial property, and is suitable for repair and reconstruction of a dermal tissue.

Injectable Therapeutic Biocompatible Co-Polymers and Methods of Making and Using Same

Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject. 1. A biocompatible copolymer , comprising:a first plurality of monomers each comprising a polysaccharide or derivative thereof;a second plurality of monomers each comprising a therapeutic agent or derivative thereof;a third plurality of monomers each comprising a thermo-responsive monomer; andan acrylamide-containing cross-linking agent.2. The biocompatible copolymer of claim 1 , wherein each of the monomers and the crosslinking agent comprise a vinyl functional group claim 1 , and wherein the vinyl functional groups form the backbone of the biocompatible co-polymer.3. The biocompatible copolymer of claim 1 , wherein the polysaccharide or derivative thereof comprises hyaluronic acid claim 1 , methacrylated hyaluronic acid claim 1 , or glycidyl methacrylated hyaluronic acid.4. The biocompatible copolymer of claim 1 , wherein the thermo-responsive monomer comprises n-vinylcaprolactam.5. The biocompatible copolymer of claim 1 , wherein the therapeutic agent or derivative thereof comprises an anti-osteoarthritic agent or derivative thereof.6. (canceled)7. The biocompatible copolymer of claim 1 , wherein the acrylamide-containing crosslinking agent is selected from the group consisting of bisacrylamide and poly(ethyleneoxide diacrylamide).8. The biocompatible copolymer of claim 1 , further comprising a surface adhesion protein.9. (canceled)10. A hydrogel implant material claim 1 , comprising the biocompatible copolymer of .11. The hydrogel implant material of claim 10 , wherein the composition is a liquid at temperatures below about 32° ...

HEART VALVE

A heart valve is at least partially constructed from a block-copolymer, the block-copolymer having a phase structure formed by its constituent blocks, and wherein the phase structure is arranged so as to produce anisotropic physical properties in the heart valve. 1. A heart valve , at least partially constructed from a block-copolymer , the block-copolymer having a phase structure formed by its constituent blocks , and wherein the phase structure is arranged so as to produce anisotropic physical properties in the heart valve.2. The heart valve according to claim 1 , wherein the heart valve comprises leaflets for actuating the valve claim 1 , and the leaflets are made from the block-copolymer with the arranged phase structure.3. The heart valve according to claim 1 , wherein the block copolymer forms a phase structure comprising cylinders of a first polymer material in a matrix of another polymer material.4. The heart valve according to claim 3 , wherein the first polymer material is a glassy polymer at body temperature and the second polymer material is a rubbery polymer at body temperature.54. The heart valve according to clam claim 3 , wherein the block-copolymer is one of SIBS30 (poly(styrene-block-isobutylene-block-styrene) claim 3 , 30% styrene); SIS30 (poly(styrene-block-isoprene-block-styrene) claim 3 , 30% styrene); SI/BS19 (poly(styrene-block-isoprene/butadiene-block-styrene) claim 3 , 19% styrene); SIS18 (poly(styrene-block-isoprene-block-styrene) claim 3 , 18% styrene); SE/BS30 (poly(styrene-block-ethylene/butylene-block-styrene) claim 3 , 30% styrene); SE/BS20 (poly(styrene-block-ethylene/butylene-block-styrene) claim 3 , 20% styrene); SE/PS20 (poly(styrene-block-ethylene/propylene-block-styrene) claim 3 , 20% styrene); and SE/PS22 (poly(styrene-block-ethylene/propylene-block-styrene) claim 3 , 22% styrene).6. The heart valve according to claim 1 , wherein the phase structure is arranged to produce layers in which the phase structure is differently ...

CELL ADHESION INHIBITOR

Provided is a cell adhesion inhibitor which exhibits low cytotoxicity and an excellent cell adhesion prevention effect; a tool and an apparatus each having a surface modified through application of the cell adhesion inhibitor thereto; a method for producing each of the surface-modified tool and apparatus; a biomedical structure and a production method therefor; and a microchannel device and a production method therefor. 122-. (canceled)23. A method for preventing a cell adhesion , the method comprising a step of using a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.24. The method for preventing a cell adhesion according to claim 23 , wherein an object for preventing the cell adhesion is a substrate claim 23 , a tool or an apparatus.25. The method for preventing a cell adhesion according to claim 23 , wherein at least a portion of the substrate claim 23 , the tool or the apparatus is coated with the polymer.26. The method for preventing a cell adhesion according to claim 23 , wherein the repeating unit having a sulfinyl group in a side chain thereof is hydrophilic.28. The method for preventing a cell adhesion according to claim 23 , wherein the polymer further comprises a hydrophobic repeating unit.29. The method for preventing a cell adhesion according to claim 28 , wherein the hydrophobic repeating unit is derived from at least one monomer selected from the group consisting of styrenes claim 28 , (meth)acrylates claim 28 , and (meth)acrylamides.30. The method for preventing a cell adhesion according to claim 23 , wherein the repeating unit having a sulfinyl group in a side chain thereof is nonionic.31. The method for preventing a cell adhesion according to claim 23 , wherein the polymer is water-soluble.32. The method for preventing a cell adhesion according to claim 23 , wherein the polymer has an HLB of 10 to 22.33. A surface-modified tool having claim 23 , on at least a portion of a surface thereof claim 23 , a polymer ...

TIMING CONTROLLED IN-SITU CROSS-LINKING OF HALYURONIC ACID DURING INJECTION

Systems and methods are disclosed for cosmetic augmentation by forming a biocompatible cross-linked polymer having a multi-phase mixture with a time release catalyst; injecting the mixture into a patient as a viscous fluid; after injection, activating the catalyst to cross-link the polymer after a predetermined period after injection into a patient; and augmenting soft tissue with the biocompatible cross-linked polymer.

MELT-STABILIZED ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE AND METHOD OF MAKING THE SAME

Various embodiments disclosed relate to melt-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of melt-stabilizing a material including UHMWPE. The method includes obtaining or providing a solid material including UHMWPE including a first concentration of free-radicals. The method includes coating at least part of the solid material with a liquid composition including at least one antioxidant, to provide a coated solid material. The method includes heating the coated solid material in an environment including oxygen, the heating being sufficient to melt at least part of the UHMWPE, to provide a heated material. The method also includes solidifying the heated material, to provide a melt-stabilized material including UHMWPE including a second concentration of free-radicals, wherein the second concentration of free-radicals is less than the first concentration of free-radicals. 1. A method of melt-stabilizing a material comprising ultra high molecular weight polyethylene (UHMWPE) , the method comprising:obtaining or providing a solid material comprising UHMWPE comprising a first concentration of free-radicals;coating at least part of the solid material with a liquid composition comprising at least one antioxidant, to provide a coated solid material;heating the coated solid material in an environment comprising oxygen, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material; andsolidifying the heated material, to provide a melt-stabilized material comprising UHMWPE comprising a second concentration of free-radicals, wherein the second concentration of free-radicals is less than the first concentration of free-radicals.2. The method of claim 1 , wherein the first concentration of free-radicals is at least about 1×10spins/g.3. The method of claim 1 , wherein the second ...

Semipermeable membrane and method of manufacturing the same

The present disclosure relates to a semipermeable membrane. The present disclosure aims to provide a semipermeable membrane having tolerance against a decrease over time in substance permeability. The present disclosure provides a semipermeable membrane containing a resin. The permeation rate of albumin in the semipermeable membrane is no lower than 30%. The albumin adsorption amount obtained when the semipermeable membrane measuring 1 cm on each side is immersed in a 0.1% albumin solution for 90 minutes is no greater than 10 μg/cm 2 . The water permeation amount obtained when water is sucked through the semipermeable membrane at a negative pressure of 3±0.2 kPa is expressed by no smaller than 1,000 L/(m 2 ·hour). The semipermeable membrane can isolate a cell from an external environment.

JOINT SPACER

A joint spacer, in particular a knee spacer and a hip spacer is provided which is long-lasting and is sufficiently cushioned and abrasion-resistant and which can also support locally very high loads. A method for treating osteoarthritis by inserting a disk-shaped member into a joint of a patient is also disclosed. 1. A joint spacer comprising:{'sup': 2', '2, 'a sphere-like shell-shaped elastic member, which forms a semi-spherical coating when slipped over a head of a femur characterized in that the shell-shaped elastic member has an opening for passage of a femoral head ligament, and tapers beyond an equator of the femoral head to a neck of the femoral head, and has a core layer in form of a spherical lune made of an elastic material having a compressive stress value greater than 7.8 N/mmat a compression of compressions between 20% and 60% or having a tensile stress value greater than 3.8 N/mmat an elongation of elongations between 20% and 60%, and'}wherein the shell-shaped elastic member has a separation line which can be separated and closed by a connector allowing it to be slipped over a head of a femur to avoid dislocation of the shell-shaped elastic member in the joint.2. The joint spacer according to claim 1 , wherein the separation line is provided with connecting means for reconnecting the separation line once installed.3. The joint spacer according to claim 2 , wherein the connecting means are nipples claim 2 , or studs claim 2 , or push buttons claim 2 , or cords claim 2 , or velcro fastener claim 2 , or form-fit connections with hinged joints or snap-hooks claim 2 , or beveled scarf joint claim 2 , or tackles claim 2 , or staples claim 2 , or material-fit connections by gluing or welding is possible.4. The joint spacer according to claim 2 , wherein the separation line is formed by two overlapping regions of the shell-shaped elastic member.5. The joint spacer according to claim 4 , wherein one of the overlapping regions comprises a plurality of knobs that ...

TRANSGLUTAMINASE TREATED PRODUCTS

The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance. 1. A method of treatment , comprising:selecting a medical device comprising an implant main body portion comprising a collagen-containing tissue matrix having a surface region that has been treated with a transglutaminase coating, and wherein the treated surface region provides at least one of an anti-adhesion or anti-abrasion property to the tissue matrix; andimplanting the medical device into or on an anatomic site.2. The method of claim 1 , wherein the implant main body portion comprises a sheet of collagen-containing tissue matrix.3. The method of claim 1 , wherein the collagen-containing tissue matrix comprises an acellular tissue matrix.4. The method of claim 1 , wherein the collagen-containing tissue matrix is produced from tissue derived from a tissue selected from fascia claim 1 , adipose claim 1 , pericardial tissue claim 1 , dura claim 1 , umbilical cord tissue claim 1 , placental tissue claim 1 , cardiac valve tissue claim 1 , ligament tissue claim 1 , tendon tissue claim 1 , arterial tissue claim 1 , venous tissue claim 1 , neural connective tissue claim 1 , urinary bladder tissue claim 1 , ureter tissue claim 1 , muscle claim 1 , and intestinal tissue.5. The method of claim 1 , wherein the collagen-containing tissue matrix is produced from tissue derived from skin.6. The method of claim 1 , wherein the collagen-containing tissue matrix comprises a dermal tissue matrix.7. The method of claim 1 , wherein the medical device is dry.8. The method of claim 1 , wherein the medical device further comprises a synthetic substrate claim 1 , wherein the collagen-containing tissue matrix is in contact with the synthetic substrate.9. ...

Bone cement applicator with three-way valve for pressure relief

Bone cement applicators and methods apply a bone cement dough in the region of the spine. The applicators and method have at least one tubular cartridge with an internal space, containing starting components of the bone cement, at least one dispensing plunger that is mobile in longitudinal direction on the inside of the at least one cartridge, a hose, an application opening through which the bone cement dough is applicable, a three-way valve being arranged in the hose or on a side of the hose facing the at least one cartridge and in fluid connection with the opening of the at least one cartridge and/or a collecting container arranged on the three-way valve for accommodation of bone cement dough. The three-way valve is appropriately designed and/or arranged in the bone cement applicator such that it, being in a first position, provides a fluid connection between the application opening and the opening of the at least one cartridge and closes a passage to the collecting container and, being in a second position, provides a fluid connection between the application opening and the collecting container and closes a passage to the opening of the at least one cartridge.

BONE CEMENT APPLICATOR WITH THREE-WAY VALVE FOR PRESSURE RELIEF

Bone cement applicators and methods for application of a bone cement dough, the applicators and methods comprise a tubular cartridge with an internal space, a dispensing plunger for expelling the starting components through an opening of the cartridge opposite from the dispensing plunger, wherein the dispensing plunger is mobile in longitudinal direction in the internal space of the cartridge. The applicators and methods further comprise a hose, an application opening, a three-way valve operable from outside and arranged or arrangeable in the hose or on a side of the hose facing the cartridge, and a collecting container arranged on the three-way valve. The three-way valve is designed and arranged or arrangeable in the applicator such that it, being in a first position, provides a fluid connection between the application opening and the opening of the cartridge and closes a feed-through to the collecting container and, being in a second position, provides a fluid connection between the application opening and the collecting container and closes a passage to the opening of the cartridge. 1. A bone cement applicator for application of a bone cement dough , the bone cement applicator comprising:a tubular cartridge with an internal space;a dispensing plunger for expelling the starting components of the bone cement dough from the cartridge through an opening of the cartridge opposite from the dispensing plunger, wherein the dispensing plunger is mobile in longitudinal direction in the internal space of the cartridge;a hose;an application opening through which the bone cement dough is applicable;a three-way valve operable from outside and arranged in the hose or on a side of the hose facing the cartridge, wherein the three-way valve is in fluid connection with the opening of the cartridge, when the three-way valve is connected to the cartridge; anda collecting container arranged on the three-way valve for accommodation of bone cement dough;wherein the three-way valve is ...

HIGH SPEED 3D PRINTING SYSTEM FOR WOUND AND TISSUE REPLACEMENT

A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less. 1. A method for creating a three-dimensional tissue construct of a desired shape for repair or replacement of tissue of a tissue cavity of an organism , the method comprising:injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material.2. The method of claim 1 , further comprising:removing the injected at least one biomaterial from the first material.3. The method of claim 2 , wherein removing the injected at least one biomaterial from the first material comprises washing away the first material.4. The method of claim 2 , further comprising:inserting the tissue construct into the tissue cavity of the organism.5. The method of claim 2 , further comprising:attaching the tissue construct to the organism at the tissue cavity.6. The method of claim 1 , wherein:injecting the at least one biomaterial comprises injecting the at least one biomaterial such that the tissue construct has a smallest feature size of less than 1 millimeter7. The method of claim 6 , wherein injecting the at least one biomaterial comprises injecting ...

INTRAOCULAR LENS MATERIAL AND METHOD FOR PRESERVING INTRAOCULAR LENS MATERIAL

A polymer produced by polymerizing a polymerizable composition including a hydrophilic monomer and a crosslinkable monomer. The A×B value that is the product of the molar fraction A of the hydrophilic monomer and the molar fraction B of the crosslinkable monomer is more than 2.1×10and less than 3.6×10. The molar fraction B of the crosslinkable monomer is less than 2.4×10. The polymer has a refractive index n of 1.5 or more in a state of hydration. 1. An intraocular lens material comprising a polymer produced by polymerizing a polymerizable composition including a hydrophilic monomer and a crosslinkable monomer ,{'sup': −3', '−3', '−2, 'wherein an A×B value is more than 2.1×10and less than 3.6×10, the A×B value being the product of a molar fraction A of the hydrophilic monomer and a molar fraction B of the crosslinkable monomer, the molar fraction B of the crosslinkable monomer is less than 2.4×10, and the polymer has a refractive index n of 1.5 or more in a state of hydration.'}2. The intraocular lens material according to claim 1 ,{'sup': '−2', 'wherein the molar fraction B of the crosslinkable monomer is less than 2.1×10.'}3. The intraocular lens material according to claim 1 ,wherein the intraocular lens material has an elongation percentage of 290% or more.4. The intraocular lens material according to claim 1 ,wherein the hydrophilic monomer includes one or more selected from a hydroxyl group-containing alkyl (meth)acrylate including an alkyl group having 1 to 20 carbon atoms, a (meth)acrylamide monomer, and an N-vinyl lactam.5. The intraocular lens material according to claim 1 ,wherein the crosslinkable monomer includes one or more selected from butanediol di(meth)acrylate and ethylene glycol di(meth)acrylate.6. The intraocular lens material according to claim 1 ,wherein the polymerizable composition includes, as main components, an aromatic-ring-containing (meth)acrylate and an alkyl (meth)acrylate including an alkyl group having 1 to 20 carbon atoms.7. A ...

ALLOPLASTIC INJECTABLE DERMAL FILLER AND METHODS OF USE THEREOF

A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided. In an embodiment of the method of augmenting soft tissue, the stimulation of collagen production is effected by injecting into the deep reticular dermis an a dermal filler, said dermal filler being an alloplastic injectable suspension and comprising a biocompatible and pliable material and a physiologically acceptable suspending agent. 131-. (canceled)32. A composition comprising: wherein the biocompatible and pliable material is a copolymer of phenylethyl acrylate and phenylethyl methacrylate; and', 'wherein said copolymer is a solid., 'an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent;'}33. The composition of claim 32 , wherein the solid copolymer is a powder claim 32 , a non-porous microbead claim 32 , or a microsphere.34. The composition of claim 32 , wherein the solid copolymer comprises particles each having a diameter of about 10μ to about 100μ; about 0.01μ to about 10μ; or about 0.01μ to about 5μ.35. The composition of claim 32 , wherein the physiologically acceptable suspending agent is resorbable.36. The composition of claim 35 , wherein the physiologically acceptable suspending agen s a buffered physiological solution claim 35 , cross- ...

UV ABSORBING OCULAR LENS

Ocular lenses having UV absorbing properties are disclosed. The ocular lens comprises a hydrogel polymer comprising polymerised residues derived from a polymerisable UV absorber of formula (I): 1. An ocular lens comprising a hydrogel polymer comprising polymerised residues derived from a polymerisable UV absorber of formula (I):{'br': None, 'U-L-Py\u2003\u2003(I)'} U is a UV absorbing moiety;', 'L is a hydrophilic non-polyalkylene glycol linker comprising an anionic, a zwitterionic or a saccharide moiety; and', 'Py is an ethylenically unsaturated polymerisable moiety., 'wherein2. The ocular lens according to claim 1 , wherein the linker (L) comprises at least 4 carbon atoms.3. The ocular lens according to claim 1 , wherein the linker (L) comprises a moiety selected from carboxylate claim 1 , sulfonate claim 1 , sulfate claim 1 , phosphate claim 1 , phosphonate claim 1 , ammonium claim 1 , and combinations thereof.6. The ocular lens according to claim 1 , wherein the linker (L) comprises a saccharide moiety selected from a furanose claim 1 , pyranose and amino sugar moiety.7. The ocular lens according to claim 6 , wherein the linker (L) comprises a glucopyranose or glucosamine moiety.9. The ocular lens according to claim 1 , wherein the UV absorbing moiety (U) absorbs radiation in both the UV-A and UV-B range.10. The ocular lens according to claim 1 , wherein the UV absorbing moiety (U) is a benzotriazole or benzophenone moiety.13. The ocular lens according to claim 1 , wherein the ethylenically unsaturated polymerisable moiety (Py) comprises a polymerisable functional group selected from allyl claim 1 , vinyl claim 1 , acryloyl claim 1 , methacryloyl and styrenyl.14. The ocular lens according to claim 1 , wherein the hydrogel polymer comprises polymerised residues derived from at least two different polymerisable UV absorbers claim 1 , wherein at least one of the polymerisable UV absorbers is of formula (I).15. The ocular lens according to claim 14 , wherein the ...

METHOD FOR CREATING A MINERAL TRIOXIDE AGGREGATE MATERIAL WITH IMPROVED BIOLOGICAL EFFECTS

A dental device is improved in its ability to produce hydroxyl apatite by having a layer of mineral trioxide aggregate (MTA) deposited thereon. A tile of MTA is prepared, heat treated and sintered to produce a micronized tile of MTA that can then be deposited by physical vapor depositions, hot isostatic pressing, molding or other conventional technique. 1. An implantable dental device comprising a layer of mineral trioxide aggregate that produces hydroxyl apatite in the presence of phosphate buffered saline.2. An implantable dental device as in wherein said device is an obturation point.3. An implantable device as in wherein said obturation point comprises gutta-percha.4. A method for producing hydroxyl apatite on a dental device comprising the step of preparing a tile of mineral trioxide aggregate.5. A method as in further comprising forming a mixture by mixing Portland cement and deionized water in an amount of from about 10:1 to about 1:10.6. A method as in wherein said mixture is placed into a mold and cured in a humidity chamber.7. A method as in wherein said humidity chamber is set at 36 degrees Celsius with about a 90 percent relative humidity for from about 5 hours to about 10 days.8. A method as in wherein said cured mixture is subjected to a second heating by heating to from about 50 to about 500 degrees Celsius for from about 15 minutes to about 2 days.9. A method as in wherein said method includes micronizing said cured tile.10. A method as in wherein said micronizing includes ball-mill grinding said tile to a particle size of from about 1 to about 200 microns.11. A method as in wherein said micronizing includes ball-mill grinding said tile to a particle size of from about 10 to about 100 microns.12. A method as in wherein said micronizing includes ball-mill grinding said tile to a particle size of about 53 microns.13. A method as in wherein said micronized tile is sintered at a temperature of from about 25 to about 400 degrees Celsius for a period of ...

TUNABLE POROUS 3D BIODEGRADABLE, BIOCOMPATIBLE POLYMER/NANOMATERIAL SCAFFOLDS, AND FABRICATING METHODS AND APPLICATIONS OF SAME

The disclosure relates to a scaffold for tissue regeneration and methods for fabricating the scaffold. The scaffold includes a three-dimensional structure composed by alternating layers of various materials including a first medium, a second medium and a third medium. The first medium includes bone particles each having a size of 1 nm to 100 mm with or without organic components. The second medium is a natural or synthetic biocompatible and/or biodegradable polymer. The third medium is a material dissolved in a solvent different than the solvent of the polymer and includes solid particulates alone or in polymeric structures that dissolve when immersed in liquid or gaseous solvent environments or based on temperature differentials. The various materials are arranged according to the shape and the size of a bone gap being generated. The three-dimensional structure has a tunable porosity with interconnected channels and pores along with adjustable dimensions. 1. A scaffold useable for tissue regeneration , comprising:a three-dimensional (3D) structure composed by alternating layers of various materials comprising a first medium, a second medium and a third medium,wherein the first medium comprises bone particles of a human, bone particles of an animal origin, or bone particles grown in the laboratory; the size of the bone particles is between 1 nm to 100 mm, and the bone particles are with or without organic components;wherein the second medium is a natural or synthetic biocompatible and/or biodegradable polymer;wherein the third medium is a material dissolved or removed in a solvent different than the solvent of the polymer used; the third medium comprises solid particulates alone or in polymeric structures or other powders that dissolve when immersed in liquid or gaseous solvent environments or based on temperature differentials;wherein the various materials are arranged in accordance with the shape and the size of a bone gap that needs to be generated; andwherein ...

CYLINDRICAL STRUCTURE

A tubular structure has succeeded in achieving excellent puncture resistance as well as maintenance of flexibility in a base by covering the base with a cover having excellent flexibility. The tubular structure includes a tubular base and a cover which covers the base, wherein the cover includes a copolymer containing a silicone monomer and a polymerizable monomer having a fluoroalkyl group(s) as monomer units. 1. A tubular structure comprising a tubular base and a cover covering said base , whereinsaid cover comprises a copolymer containing a silicone monomer and a polymerizable monomer having a fluoroalkyl group(s) as monomer units.3. The tubular structure of claim 2 , wherein said Xand Xare (meth)acryloyl groups.5. The tubular structure of claim 1 , which satisfies Expression (1):{'br': None, 'i': I', '/I, 'sup': 1', '2, '≤5.0\u2003\u2003(1)'}{'sup': 1', '−1', '2', '−1, 'wherein Irepresents an absorbance of 1740 to 1780 cmdue to stretching vibration of C═O originated from ester groups; and Irepresents an absorbance of 1430 to 1470 cmdue to bending vibration of C—H originated from alkyl groups,'}when the surface of said cover is subjected to a measurement by single-reflection infrared spectroscopy at a wavelength of 2.5 to 25 m and an angle of incidence of 45°.6. The tubular structure of claim 1 , wherein said copolymer has a carboxyl group(s) and/or a hydroxyl group(s).8. The tubular structure of claim 1 , wherein said base is composed of a polyester claim 1 , polyurethane claim 1 , or polytetrafluoroethylene.9. The tubular structure of claim 1 , wherein said tubular base is a tubular woven fabric comprising warp yarns and weft yarns claim 1 , said tubular structure having an outer diameter with a variation of within 10% along the warp direction and satisfying Expression (2):{'br': None, 'i': L', 'L', 'L, '(2−1)/1≥0.1\u2003\u2003(2)'}wherein L1 is a gauge length of the tubular woven fabric when compressed in the warp direction by applying a stress of 0.01 cN/dtex ...

Tissue expansion method

The invention provides a method for skin expansion utilizing at least one polymer.

Cell Encapsulation Devices Containing Structural Spacers

An implantable containment apparatus for receiving and retaining a plurality of cells for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a chamber having structural spacers therein to maintain an average distance between the first interior surface and the second interior surface of the chamber and to define at least one reservoir space for the placement of cells within the chamber. 1. An encapsulation device comprising:a first layer sealed along a portion of its periphery to a second layer along a portion of its periphery to define a chamber comprising a first interior surface and an opposing second interior surface;structural spacers disposed within the chamber to interconnect the first interior surface and the second interior surface and,wherein the structural spacers maintain an average distance both under external compressive forces and under internal expansive forces.2. The encapsulation device of claim 1 , comprising at least one reservoir space configured to receive a plurality of cells.3. The encapsulation device of claim 1 , comprising a plurality of reservoir spaces that are fluidly interconnected.4. The encapsulation device of claim 3 , wherein the plurality of reservoir spacers are interconnected by channels formed by the structural spacers.5. The encapsulation device of claim 1 , wherein the chamber comprises at least two reservoir spaces that are discrete.6. The encapsulation device of claim 1 , wherein the structural spacers cover from about 5% to about 50% of the first and second interior surfaces.7. The cell encapsulation device of claim 1 , wherein at least one of the first and second layers is a composite layer comprising:a) an outer porous layer; andb) an inner porous layer adjacent to the outer porous layer, wherein the inner porous layer has a porosity that is less than the outer porous layer, and wherein a portion of the inner porous layer is the first or second interior surface.8. The cell encapsulation ...

Electroactive Materials Comprising A Piezoelectric Polymer And A Conducting Polymer

In one embodiment, an electroactive material includes a piezoelectric polymer substrate and a conducting polymer coating provided on the substrate. 1. An electroactive material comprising:a piezoelectric polymer substrate; anda conducting polymer coating provided on the substrate.2. The electroactive material of claim 1 , wherein the piezoelectric polymer is poly(vinylidene fluoride) (PVDF).3. The electroactive material of claim 1 , wherein the conducting polymer is polypyrrole (PPy).4. The electroactive material of claim 1 , wherein the substrate comprises fibers made of the piezoelectric polymer and wherein the conducting polymer is coated on the fibers.5. The electroactive material of claim 4 , wherein the fibers comprise part of a scaffold.6. The electroactive material of claim 4 , wherein the fibers comprise electrospun fibers.7. The electroactive material of claim 1 , wherein the conducting polymer coating is formed on the substrate using in situ polymerization.8. The electroactive material of claim 7 , wherein the in situ polymerization comprises electrochemical polymerization.9. The electroactive material of claim 1 , wherein the conducting polymer comprises a biotin doping agent.10. The electroactive material of claim 9 , wherein the conducting polymer is loaded with a therapeutic substance.11. The electroactive material of claim 10 , wherein the therapeutic substance is a drug.12. The electroactive material of claim 10 , wherein the therapeutic substance is a growth factor.13. A method for forming an electroactive material claim 10 , the method comprising:forming a substrate from a piezoelectric polymer; andcoating the substrate with a conducting polymer.14. The method of claim 13 , wherein forming a substrate comprises electrospinning fibers of the piezoelectric polymer.15. The method of claim 13 , wherein coating the substrate comprises polymerizing the conducting polymer on the substrate in situ.16. The method of claim 15 , wherein polymerizing ...

POLYMER-PERMEATED GRAFTS AND METHODS OF MAKING AND USING THE SAME

This invention is directed to polymer-permeated grafts and methods of making and using the same. 1. An polymer-permeated graft for in vivo use in a subject comprising a tissue substantially free of cells , wherein the decellularized tissue is substantially free of water and is permeated with polymer , and wherein the polymer is substantially uniformly distributed in said tissue.2. The graft of claim 1 , wherein the graft comprises less than about 50% polymer.3. The graft of claim 2 , wherein the graft comprises about 0.1% to about 30% polymer.4. The graft of claim 1 , wherein the tissue comprises a dermal tissue and/or an epidermal tissue.5. The graft of claim 1 , wherein the tissue comprises an organ claim 1 , a muscle claim 1 , a ligament claim 1 , a bone claim 1 , a nipple claim 1 , areola claim 1 , a nipple attached to an areola claim 1 , a lip claim 1 , skin claim 1 , a tendon claim 1 , an aorta claim 1 , a blood vessel.6. The graft of claim 1 , wherein the tissue substantially retains at least one matrix molecule.7. The graft of claim 1 , wherein the matrix molecule comprises a component of the extracellular matrix.8. The graft of claim 1 , wherein the matrix molecule comprises laminin claim 1 , elastin claim 1 , fibronectin claim 1 , collagen claim 1 , or a combination thereof.9. The graft of claim 8 , wherein the collagen comprises a Type I collagen claim 8 , a Type III collagen claim 8 , a Type IV collagen claim 8 , a Type VI collagen claim 8 , or a combination thereof.10. The graft of claim 1 , wherein the tissue is substantially free of skin claim 1 , fat and/or fibrous tissue.11. The graft of claim 1 , wherein the polymer comprises a colored polymer.12. The graft of claim 11 , wherein the colored polymer comprises melanin claim 11 , a dye claim 11 , or a combination thereof.13. The graft of claim 1 , wherein the polymer comprises a natural polymer and/or a synthetic polymer.14. The graft of claim 1 , wherein the natural polymer comprises alginate or ...

HYDROPHOBIC INTRAOCULAR LENS

An intraocular lens (IOL) with excellent non-glistening characteristics comprising at least one copolymer comprising: (a) one or more first monomeric subunits comprising a polymerized acrylate and/or methacrylate group, at least one side group comprising (i) an aryloxy moiety, and (ii) an aliphatic carbon moiety linking the aryloxy moiety with the polymerized acrylate or methacrylate group, wherein the aliphatic carbon moiety comprises at least one hydroxyl substituent, (b) one or more second monomeric subunits different from the first monomeric subunits comprising a polymerized acrylate and/or methacrylate group, and comprising at least one alkoxyalkyl side group, (c) one or more third monomeric subunits different from the first and second monomeric subunits, the third monomeric subunits comprising a polymerized acrylate and/or methacrylate group, and comprising at least one alkylene oxide side group, wherein the first monomeric subunit is present in a greater amount by weight than the second monomeric subunit, and the first and second monomeric subunits together comprise about 75 percent or more of the monomeric subunits composition by weight. 153.-. (canceled)54. A composition comprising at least one copolymer comprising:(a) a first monomeric subunit comprising a polymerized methacrylate group, at least one side group comprising (i) an aryloxy moiety, and (ii) an aliphatic carbon moiety linking the aryloxy moiety with the polymerized acrylate or methacrylate group, wherein the aliphatic carbon moiety comprises at least one hydroxyl substituent, and(b) a second monomeric subunit different from the first monomeric subunit comprising a polymerized methacrylate group, and comprising at least one alkoxyalkyl side group,(c) a third monomeric subunit different from the first and second monomeric subunits, the third monomeric subunits comprising a polymerized acrylate or methacrylate group, and comprising at least one alkylene oxide side group,wherein the first monomeric ...

Adhesive composition for carrying therapeutic agents as delivery vehicle on coating applied to vascular grafts

Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.

Biodegradable, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy

Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.

Stabilization of Essential Oils Within a Hydrocolloid Adhesive

Various adhesive compositions are described which comprise one or more essential oils. The adhesive compositions may optionally comprise one or more active agents such as pharmaceutical agents. Also described are related methods of improving the stability of essential oil(s) in adhesive compositions by incorporating polyvinylpyrrolidone. Also described are related methods of using the compositions and articles incorporating such compositions. 1. A method of enhancing the stability of essential oils in an adhesive composition , wherein the adhesive composition comprises an adhesive component , at least one essential oil , and an absorbent , the method comprising:providing polyvinylpyrrolidone;incorporating the polyvinylpyrrolidone in the adhesive composition, whereby the stability of the essential oils is enhanced.2. The method of claim 1 , wherein the absorbent is selected from the group consisting of insoluble swellable polymers claim 1 , hydratable polymers claim 1 , water soluble polymers claim 1 , synthetic absorbents claim 1 , super absorbent polymers claim 1 , and combinations thereof3. The method of claim 2 , wherein the absorbent is carboxymethyl cellulose.4. The method of claim 3 , wherein the carboxymethyl cellulose has a degree of substitution within a range from 0.2 to 1.5.54. The method of any one of - claims 3 , wherein the carboxymethyl cellulose has a molecular weight in a range from 17 claims 3 ,000 to 700 claims 3 ,000.65. The method of any one of - wherein the adhesive composition further comprises an active agent.7. The method of claim 6 , wherein the active agent is selected from the group consisting of analgesics claim 6 , local anesthetics claim 6 , anti-acne agents claim 6 , anti-angina agents claim 6 , antiarrhythmics claim 6 , antibacterial claim 6 , anti-convulsives claim 6 , antidepressants claim 6 , anti-rheumatics claim 6 , sex hormones claim 6 , anti-fungals claim 6 , anti-hypertensives claim 6 , anti-hypothyroid agents claim 6 , anti- ...

IMPLANTABLE MEDICAL DEVICE FOR LUBRICATING AN ARTIFICIAL CONTACTING SURFACE

An implantable medical device, for implantation in a mammal knee joint, comprising an artificial contacting surface adapted to replace at least one contacting surface of the knee joint and to be lubricated when implanted in said joint. The medical device further comprises a reservoir comprising a movable wall portion defining the volume of the reservoir, at least one inlet adapted to receive a lubricating fluid from the reservoir, at least one channel at least partly integrated in said artificial contacting surface, wherein the channel is fluidly connected with said at least one inlet for distributing said lubricating fluid to the surface of said artificial contacting surface. The medical device further comprises an operation device adapted to non-invasively transport said lubricating fluid from said reservoir to said artificial contacting surface, and an implantable injection port for refilling said reservoir, wherein the movable wall portion is moved when the reservoir is refilled, such that the volume of the reservoir is increased. 1104.-. (canceled)105. An implantable medical device , for implantation in a mammal knee joint , comprising:an artificial contacting surface adapted to replace at least one contacting surface of the knee joint and to be lubricated when implanted in said joint;a reservoir comprising a movable wall portion defining the volume of the reservoir;at least one inlet adapted to receive a lubricating fluid from the reservoir;at least one channel at least partly integrated in said artificial contacting surface, wherein the channel is fluidly connected with said at least one inlet for distributing said lubricating fluid to the surface of said artificial contacting surface;an operation device adapted to non-invasively transport said lubricating fluid from said reservoir to said artificial contacting surface; andan implantable injection port for refilling said reservoir, wherein the movable wall portion is moved when the reservoir is refilled, such ...

Total hip surface replacement implant

A total hip surface replacement implant, comprising a femur component and an acetabular cup component, wherein the femur component is in a half-spherical shell shape and is formed by polyether ether ketone (PEEK) or derivatives thereof; the shape of the acetabular cup component matches that of the femur component, and the acetabular cup component is tightly attached to an outer surface of the half-spherical shell of the femur component; the acetabular cup component is formed by ultrahigh molecular weight polyethylene; or the femur component can be formed by ultrahigh molecular weight polyethylene, and meanwhile the acetabular cup component is formed by polyether ether ketone (PEEK) or derivatives thereof. The total hip surface replacement implant employs friction combination between organic polymers so as to reduce material toxicity against a living body; the rigidity of the organic polymers more matches that of a natural bone of a human body, thereby reducing implant wearing in a usage process; and by means of an optimization design of a positioning column on a femur condyle, the clinic problems of early neck-of-femur fracture and medium-and-long term bone resorption are avoided.

PLASTIC MATERIAL FOR DEVICES TO BE IMPLANTED INTO THE HUMAN BODY OR FOR ARTICULAR SPACERS

Biocompatible and implantable in the human body plastic material, for the obtainment of a device that can be implanted in the human body or a spacer device in order to treat a bone or a joint location, including an acrylic resin or polyethylene (PE) or low density polyethylene or high density polyethylene or ultra-high molecular weight polyethylene (UHMWPE) or polypropylene or polyamide or polyetheretherketone (PEEK) or a thermosetting resin or a mixture of the same, wherein the material can be molded and includes at least one pharmaceutical or medical substance; device implantable in the human body or spacer device for treating a bone or a joint location, obtained by the material above and method for manufacturing the material according to the present invention. 1. Material biocompatible and implantable in the human body , for the obtainment of a device that can be implanted in the human body or a spacer device in order to treat a bone or a joint location , comprising a plastic material such as ultra high molecular weight polyethylene (UHMWPE) or polyethylene (PE) or low density polyethylene or high density polyethylene or polypropylene or polyamide or polyetheretherketone (PEEK) or an acrylic resin or a thermosetting resin or a mixture of the above , characterized in that it comprises at least one pharmaceutical or medical substance comprising at least one antibiotic and in that said biocompatible material is moldable.2. Material according to claim 1 , wherein said biocompatible material comprises a radio-opacifying agent and/or a further additive.3. Material according to or claim 1 , wherein said plastic material is in form of granules or powder and/or wherein said plastic material is crushed or granulated or reduced in the form of granules or of powder and/or wherein said thermosetting resin comprises silicone claim 1 , silicone elastomer claim 1 , polyurethane claim 1 , rigid and/or elastic polyurethane claim 1 , or a mixture thereof claim 1 , etcetera.4. ...

COMBINED FULLY ORGANIC HIGH MOLECULAR MATERIAL ARTIFICIAL KNEE JOINT

A combined fully organic high molecular material artificial knee joint, comprising a femur condyle (), a tibia holder () and a tibia liner (), the femur condyle () and the tibia holder () being formed by polyether ether ketone (PEEK) or derivatives thereof, and the tibia liner () being formed by ultra-high molecular weight polyethylene (UHMWPE). The tibia holder () comprises a platform () and a stable wing positioning portion () vertical thereto; upper and lower ends of the tibia liner () are jointed with the femur condyle () and the platform () respectively; the femur condyle () buffers a slide surface of the tibia liner (); and the tibia holder () can finely move relative to a fixed surface of the tibia liner (), and buffering of the femur condyle () against the slide surface of the tibia liner () matches fine movement of the tibia holder () relative to the tibia liner (). Main parts of all implant components of the artificial knee joint are formed by high molecular materials, thereby relieving allergy and toxicity problems probably caused by metal and metal corrosion; PEEK elastic modulus matches a natural bone, thereby relieving a stress shield problem; a wearing problem is greatly relieved by means of the combination of buffering of the PEEK femur condyle () against the slide surface of the UHMWPE tibia liner () and fine movement of the tibia holder () relative to the fixed surface of the UHMWPE tibia liner (); and meanwhile, by adding enhancement and developing components, the practicality is further improved. 110-. (canceled)11. A combined fully organic high molecular material artificial knee joint comprising:a femur condyle;a tibia liner;a tibia holder;wherein the tibia holder comprises a platform and a stable wing positioning portion vertical thereto;wherein the femur condyle is jointed to an upper end of the tibia liner and the platform of the tibia holder is jointed to a lower end of the tibia liner;wherein the femur condyle, the tibia holder and the ...

MATERIAL FOR THE MOLDING OF DEVICES TO BE IMPLANTED INTO THE HUMAN BODY OR OF ARTICULAR SPACERS

Material biocompatible and implantable in the human body, for the obtainment of a device that can be implanted in the human body or a spacer device for treating a bone or a joint seat, including an acrylic resin or a plastic material or polyethylene (PE) or low density polyethylene or high density polyethylene or ultra high molecular weight polyethylene (UHMWPE) or polypropylene or polyamide or polyetheretherketone (PEEK) or a mixture thereof, wherein the material can be moulded and includes an additive such as a pharmaceutical or medical substance and/or a radio-opacifying agent and/or a further additive; device that can be implanted in the human body or a spacer device for treating a bone or a joint location obtained with the aforementioned material and method for obtaining the material according to the present invention. 1. Material biocompatible and implantable in the human body , for the obtainment of a device that can be implanted in the human body or a spacer device for treating a bone or a joint location , comprising a plastic material such as an acrylic resin or a plastic material or polyethylene (PE) or low density polyethylene or high density polyethylene or ultra high molecular weight polyethylene (UHMWPE) or polypropylene or polyamide or polyetheretherketone or a mixture of the above , characterized in that it comprises an additive such as a pharmaceutical or medical substance and/or a radio-opacifying agent and/or a further additive and in that said biocompatible material is moldable.2. Material according to claim 1 , wherein said biocompatible material is extruded or extrudable into a thread.3. Material according to claim 2 , wherein said thread has a diameter comprised between 1 and 10 mm or between 1 and 5 mm.4. Material according to any one of the preceding claims claim 2 , wherein said biocompatible material is a material moldable by means of a tridimensional printer or by means of injection molding or by means of molding presses or using a ...

Instruments and methods for the implantation of cell-seeded substrates

Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

POROUS COMPOSITES WITH HIGH-ASPECT RATIO CRYSTALS

The present disclosure is directed toward composite materials comprising high aspect ratio habits of drug crystals which can be partially or fully extending into a substrate, and additionally, can be projecting from a substrate at an angle of about 20° to about 90°. The present disclosure is directed toward medical devices, such as medical balloons, comprising said composite and methods of using and making the same. The described composite can be used for the local treatment of vascular disease. The present disclosure is also directed toward paclitaxel crystals with a hollow acicular habit. 1. A method of preparing a composite comprising a porous substrate and a drug crystal of high aspect ratio habit , such that the crystals are at least partially extending into the substrate and are projected from substrate at an angle of about 20 to 90 degrees with respect to the substrate and comprising the steps ofpreparing a solution of drug in the organic solvent, wherein the organic solvent is capable of wetting the substrate;applying the solution to the porous substrate; andcausing the solvent to evaporate to form the drug crystal.2. The method of claim 1 , wherein the substrate comprises a node and fibril microstructure.3. The method of claim 1 , wherein the substrate comprises ePTFE.4. The method of claim 1 , wherein the drug comprises paclitaxel.5. The method of claim 1 , wherein the drug crystal is a hollow claim 1 , acicular crystal.6. The method of claim 1 , wherein the organic solvent comprises methanol.7. The method of claim 1 , further comprising the step of treating the composite with at least one of solvent annealing claim 1 , vapor annealing claim 1 , and thermal annealing.8. The method of claim 1 , wherein applying the solution comprises at least one of pipetting claim 1 , dipping and spraying.9. The method of claim 1 , further comprising the step of applying a non-solvent claim 1 , wherein the non-solvent comprises at least one of water claim 1 , and ethyl ...

Electrospun material covered medical appliances and methods of manufacture

A medical appliance or prosthesis may comprise one or more layers of electrospun nanofibers, including electrospun polymers. The electrospun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Electrospun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis.

BONE CEMENT COMPOSITION AND KIT THEREOF

The present invention provides a bone cement composition comprising a bone matrix and a bone cement matrix formed by an acrylic polymer and an acrylic monomer, wherein the ratio of the bone matrix to the bone cement matrix is in a range from about 1:2 (g/g) to about 1:1000 (g/g). The present invention further provides a bone cement composition kit comprising a bone matrix component, a powder component, and a liquid component, respectively stored in separate containers, wherein the bone matrix component includes a bone matrix, the powder component includes an acrylic polymer, and the liquid component includes an acrylic monomer. The powder component and the liquid component are mixable to produce a bone cement matrix component. A ratio of the bone matrix component to the bone cement matrix component is in a range from about 1:2 (mL/mL) to about 1:50 (mL/mL). 1. A bone cement composition , comprising a bone matrix and a bone cement matrix formed by an acrylic polymer and an acrylic monomer , wherein the ratio of the bone matrix to the bone cement matrix is in a range from about 1:2 (g/g) to about 1:1000 (g/g) , and the ratio of the acrylic polymer to the acrylic monomer is in a range from about 1:10 (g/g) to about 20:1 (g/g).2. The bone cement composition of claim 1 , wherein the bone matrix is further mixed with a vehicle to produce a bone matrix component.3. The bone cement composition of claim 2 , wherein the bone matrix component is provided in the bone cement composition in the form of clay claim 2 , granule claim 2 , or powder.4. The bone cement composition of claim 2 , wherein the vehicle is selected from the group consisting of cellulose claim 2 , cellulose derivatives claim 2 , glycerol claim 2 , polyethylene glycol (PEG) claim 2 , glycosaminoglycan claim 2 , collagen claim 2 , gelatin claim 2 , ethylene glycol claim 2 , propylene glycol claim 2 , polyhydroxyalkanoate (PHA) claim 2 , polylactic acid (PLA) claim 2 , polyglycolic acid (PGA) claim 2 , poly( ...

MATERIALS THAT SHRINK IN ONE DIMENSION AND EXPAND IN ANOTHER DIMENSION

A substrate includes a double-network polymer system including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the substrate has a moisture level less than or equal to 15 percent of the total weight of the substrate, and wherein the substrate includes a latent retractive force. A method for manufacturing a substrate includes producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer; elongating by force the double-network hydrogel in at least one direction; dehydrating while still elongated the double-network hydrogel to form a substantially-dehydrated double-network polymer system; and releasing the force to produce the substrate. 19-. (canceled)10. A method for manufacturing a substrate , the method comprising:producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer;elongating by force the double-network hydrogel in at least one direction;dehydrating while still elongated the double-network hydrogel to form a substantially-dehydrated double-network polymer system; andreleasing the force to produce the substrate, wherein elongating and dehydrating captures a latent retractive force in the substrate.11. The method of claim 10 , wherein dehydrating dries the double-network polymer system to less than or equal to 15% moisture of the total weight of the double-network polymer system.12. (canceled)13. The method of claim 10 , wherein the substrate is configured to release the retractive force when exposed to liquid.14. The method of claim 13 , wherein the release of the retractive force results in the substrate shrinking in at least one dimension.15. The method of claim 14 , wherein the release of the retractive force results in the substrate expanding in at least one dimension that is different from the shrinking dimension.16. The method of claim 10 , wherein the cross-linked ...

RESIN COMPOSITION AND MOLDED ARTICLE

The invention contains a resin and a near infrared fluorescent material which is one type or two or more types of compounds selected from General Formulas (I) to (I) and has a maximum fluorescence wavelength of 650 nm or longer. In Formulas, Rand R, Rand R, Rand R, and Rand Rform rings together with the nitrogen atom to which R, R, R, and Rare bonded; Rand Rrepresent a halogen atom or an oxygen atom; each of R, R, R, and Rindependently represents a halogen atom, a Calkyl group, a Calkoxy group, an aryl group, or a heteroaryl group; R, R, and Rrepresent a hydrogen atom or an electron withdrawing group; and each of Rand Rindependently represents a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, an aryl group, or a heteroaryl group. 112-. (canceled)14. The method of producing a resin composition according to claim 13 ,wherein the near infrared fluorescent material is compatible with the resin.15. The method of producing a resin composition according to claim 13 ,wherein the content of the near-infrared fluorescent material in the resin composition is 0.001% by mass to 0.05% by mass.16. The method of producing a resin composition according to claim 13 ,wherein the resin is a thermoplastic resin.17. The method of producing a resin composition according to claim 13 ,wherein the maximum fluorescence wavelength is 700 nm or longer.18. The method of producing a resin composition according to claim 16 , which is used as a medical material.19. The method of producing a resin composition according to claim 13 , comprising:further processing the resin composition to make a molded article which can be detected by light-emission.20. The method of producing a resin composition according to claim 19 ,wherein at least a part of the molded article is a medical tool that is used in the body of a patient. The present invention relates to a resin composition which emits near infrared fluorescent and a molded article obtained by processing the resin composition.A near ...

ACTUATOR

The present invention provides an actuator, comprising a fiber and a temperature regulator capable of at least one of heating and cooling the fiber. The fiber is twisted around a longitudinal axis thereof. The fiber is folded so as to have a shape of a cylindrical coil. The fiber is formed of linear low-density polyethylene. The following mathematical formula (I) is satisfied: D/d<1 (I), where D represents a mean diameter of the cylindrical coil; and d represents a diameter of the fiber. 1. An actuator , comprising:a fiber; anda temperature regulator capable of at least one of heating and cooling the fiber, whereinthe fiber is twisted around a longitudinal axis thereof;the fiber is folded so as to have a shape of a cylindrical coil;the fiber is formed of linear low-density polyethylene; and {'br': None, 'i': 'D/d<', '1\u2003\u2003(I)'}, 'the following mathematical formula (I) is satisfiedwhereD represents a mean diameter of the cylindrical coil; andd represents a diameter of the fiber.2. The actuator according to claim 1 , whereinthe longitudinal axis of the fiber accords with a rotation direction of the cylindrical coil.3. The actuator according to claim 1 , wherein{'sup': 3', '3, 'the fiber has a density of not less than 0.915 g/cmand not more than 0.925 g/cm;'}the fiber has a weight-average molecular weight of not less than 50 kg/mol and not more than 200 kg/mol;{'sub': 2', '2', 'n', '2', 'm, 'the fiber is composed of ethylene monomer units each represented by the chemical structural formula —(CHCH)— (where n is a natural number) and α-olefin monomer units each represented by the chemical structural formula —(CHCHR)— (where m is a natural number, and R represents a hydrocarbon group);'}each of the α-olefin monomer units has a carbon number of not less than 4 and not more than 8; anda molar ratio of the α-olefin monomer units to the ethylene monomer units is not less than 2.5% and not more than 3.5%.4. The actuator according to claim 1 , whereinone end of the ...

Interpenetrating Networks With Covalent and Ionic Crosslinks

The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer. 1. A composition comprising a self-healing interpenetrating networks hydrogel comprising a first network and a second network , wherein said first network comprises covalent crosslinks and said second network comprises ionic or physical crosslinks.2. The composition of claim 1 , wherein said first network and said second network are covalently coupled.3. The composition of claim 1 , wherein said first network comprises a polyacrylamide polymer and said second network comprises an alginate polymer.4. The composition of claim 3 , wherein said the weight ratios of acrylamide to (acrylamide plus alginate) are from 66.67 wt. % to 94.12 wt. %.5. The composition of claim 1 , wherein said interpenetrating polymer network comprises at least 30 wt % water.6. The composition of claim 1 , wherein said interpenetrating polymer network comprises at least at least 80 wt % water.7. The composition of claim 1 , wherein said interpenetrating polymer network comprises between 30-98 wt % water.8. The composition of claim 1 , wherein said interpenetrating polymer network comprises a fracture toughness value of at least 10 J/m.9. The composition of claim 1 , wherein said interpenetrating polymer network comprises a fracture toughness value of at least 1000 J/m10. The composition of claim 1 , wherein said interpenetrating polymer network comprises a fracture toughness value of at least 5000 J/m.11. The composition of claim 1 , wherein said interpenetrating polymer network comprises a fracture toughness value of at least 9000 J/m.12. The composition of claim 4 , wherein said interpenetrating networks hydrogel comprises ...

Acrylic Cements for Bone Augmentation

The embodiments relate to an injectable composition for a bone cement material comprising a dry powder component, a liquid component and a modifier configured to modify a Young's modulus of the bone cement material. The modifier is linoleic acid or a derivative thereof and is present in a concentration of 0.1 to 12 v/v of the liquid component.

ARTIFICIAL BIOMATERIAL COMPRISING COPPER-BASED COMPOUND

An artificial biomaterial comprises: a biocompatible matrix suitable for insertion into the human body; and either a coating layer comprising the copper-based compound, formed on the surface of the matrix, or the copper-based compound dispersed in the matrix to form a bulk material, wherein the copper-based compound has a chemical structure of CuM, wherein M is any one selected from among elements belonging to groups 15 to 17 of the periodic table, and x/y=0.8-1.5. 120.-. (canceled)21. An artificial biomaterial comprising a copper-based compound , the artificial biomaterial comprising:a biocompatible matrix suitable for insertion into the human body; andeither a coating layer comprising the copper-based compound, formed on the surface of the matrix, or the copper-based compound dispersed in the matrix to form a bulk material.{'sub': x', 'y, 'wherein the copper-based compound has a chemical structure of CuM, wherein M is any one selected from among elements belonging to groups 15 to 17 of the periodic table, and x/y=0.8-1.5.'}22. The artificial biomaterial of claim 21 , wherein M is any one selected from among S claim 21 , F and Cl.23. The artificial biomaterial of claim 21 , wherein the compound is copper sulfide.24. The artificial biomaterial of claim 21 , wherein the compound is contained in an amount of more than 0 wt % but not more than 50 wt % based on the weight of the bulk material.25. The artificial biomaterial of claim 21 , wherein the compound is contained in an amount of 0.01-30 wt % based on the weight of the bulk material.26. The artificial biomaterial of claim 21 , wherein the coating layer is formed by any one method selected from among wet application claim 21 , vapor deposition claim 21 , and coating.27. The artificial biomaterial of claim 26 , wherein the coating layer is formed by wet application claim 26 , and a coating solution for forming the coating layer contain the compound in an amount of more than 0 wt % but not more than 50 wt %.28. The ...

AUTOMATED HAND

The invention relates to an automated hand, such as a prosthetic hand. In one form, the automated hand may be fluid compatible. In one form, the automated hand may comprise features to reduce the risk of harm to motors and/or other sensitive components of the hand when subject to an impact. In one form, the hand may comprise a wrist joint configured to allow the hand to curl and flex and/or to rotate. In one form, one or more digits of the hand may be individually controlled. In one form the hand may include a thumb rotation locking mechanism. In one form the hand may be provided with removable grip plates. In one form, the hand may be configured for use as a training hand. 1. An automated hand comprising:a. a palm;b. one or more resiliently flexible and compressible mounts attached to the palm; andc. one or more connector, each having a digit extending therefrom that is moveable relative to the palm, each connector mounted to a respective mount such that each connector may rotate about the mount when a lateral force is applied to a digit.2. An automated hand as claimed in wherein each connector may rotate in the plane of the palm.3. An automated hand as claimed in wherein each connector may rotate in a plane normal to the plane of the palm.4. An automated hand as claimed in including a plurality of connectors.5. An automated hand as claimed in including a plurality of discrete mounts.6. An automated hand as claimed in wherein the one or more mounts is a single integrally formed mount.7. An automated hand as claimed in wherein each mount has an aperture formed therein dimensioned to receive a respective connector.8. An automated hand as claimed in wherein each aperture is non-circular in cross-section and each connector has a non-circular cross-section to prevent rotation between the connector and the mount.9. An automated hand as claimed in wherein each mount is formed of a material having a DMTA damping factor of between 0.05 to 0.8 over a temperature range of −20 ...

ELECTROSPUN CATIONIC NANOFIBERS AND METHODS OF MAKING AND USING THE SAME

Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft. 1. A method of making a polycationic nanofiber comprising (a) electrospinning a neutral polymer to produce nanofibers less than 2 μm in diameter and (b) grafting a cationic polymer onto the neutral polymer nanofibers to produce a polycationic nanofiber.2. The method of claim 1 , wherein the neutral polymer has a free acyl claim 1 , anhydride or carboxyl group.3. (canceled)4. The method of claim 2 , wherein the neutral polymer is poly-styrene maleic anhydride.5. The method of claim 1 , wherein the neutral polymer is dissolved in a solution at a concentration of between 40% and 200% (w/v) prior to electrospinning.6. (canceled)7. (canceled)8. The method of claim 1 , wherein the cationic polymer is selected from the group consisting of polyethyleneimine (PEI) claim 1 , branched PEI (bPEI) claim 1 , polyamidoamine (PAMAM) claim 1 , in particular PAMAM generations 0-4 or other dendrimers claim 1 , copolymers containing any combination of N claim 1 ,N′-cystaminebisacrylamide and N claim 1 ,N′-hexamethalyne bisacrylamide backbone components with histamine and 3-(dimethylamino)-1-propylamine linkers.9. (canceled)10. The method of claim 1 , wherein the grafting of step (b) comprises incubating the nanofibers of step (a) with a solution comprising the cationic polymer for at least 24 hours at concentrations of 0.009M to 1M.11. The method of claim 1 , wherein the nanofibers produced are between 0.1 μm and 2 μm in diameter.12. The ...

GORE-TEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION AND INFECTION WHILE REDUCING PALPABILITY

This invention relates generally to a breast implant having an ePTFE layer, a Silicone layer of a breast implant core, and an interface between the ePTFE layer and the Silicone layer. 1. An improved breast implant , comprising:an ePTFE layer;a Silicone layer of a breast implant core; andan interface between the ePTFE layer and the Silicone layer.2. The breast implant of claim 1 , wherein the interface is a mechanical interface.3. The breast implant of claim 2 , wherein the mechanical interface further comprises a plurality of mechanical coupling elements.4. The breast implant of claim 3 , wherein the mechanical coupling elements have a tetrapod shape.5. The breast implant of claim 1 , wherein the interface is an adhesive interface. This application is a continuation of U.S. patent application Ser. No. 14/876,754, filed Oct. 6, 2015, which claims priority to and the benefit of U.S. Provisional Application No. 62/066,704, entitled “EPTFE IMPLANTS”, filed Oct. 21, 2014, and which claims priority to and the benefit of U.S. Provisional Application No. 62/060,480, entitled “CORTEX COVERED BREAST IMPLANTS TO MINIMIZE CAPSULAR REACTION”, filed Oct. 6, 2014, which applications are hereby incorporated in their entirety by reference.Implant can be used to augment particular areas of the human body, such as calves, breasts and others. Implantation of implants can be used for reconstructive purposes or cosmetic purposes. For breast implants, reconstructive implantation purposes can include implantation after mastectomy for breast cancer, where a woman has had one or both breasts removed, while cosmetic reasons for implantation can include to change the size, firmness, or shape of the breast or for other aesthetic reasons.Current breast implants include saline implants and silicone implants. Saline implants can include silicone shells filled with sterile salt water such as saline. Silicone implants can include silicone shells filled with silicone gel. Implantation procedures ...

STABILIZATION OF VERTEBRAL BODIES WITH BONE PARTICLE SLURRY

A medical implant comprises a slurry of bone particles that are injected into a vertebral body under pressure. The liquid component of the slurry may be aspirated while the slurry is being injected so that the bone particles of the slurry pack into the central area of the vertebral body to provide structural support. The injected slurry may be agitated during the procedure to maximize the structural strength of the implant after the procedure. 1. A surgical kit comprising:a cannula configured for accessing the interior portion of a human vertebral body;a slurry of bone particles;a slurry pump configured to force at least some of the slurry of bone particles down the cannula and into the interior portion of the vertebral body.2. The surgical kit of claim 1 , wherein the cannula has an inner diameter of between 2.5 and 5 millimeters.3. The surgical kit of claim 1 , wherein the distal end of the cannula comprises at least one slurry output opening.4. The surgical kit of claim 3 , wherein at least one slurry output opening is positioned on the side of the cannula.5. The surgical kit of claim 1 , comprising a catheter having a proximal end and a distal end claim 1 , the catheter being configured to be inserted into the vertebral body through the cannula.6. The surgical kit of claim 5 , wherein the catheter has an inner diameter of between 1.5 and 2.5 millimeters.7. The surgical kit of claim 5 , wherein the distal end of the catheter comprises at least one slurry output opening.8. The surgical kit of claim 7 , wherein at least one slurry output opening is positioned on the side of the catheter.9. The surgical kit of claim 1 , wherein the slurry is 20-85% bone by volume.10. The surgical kit of claim 1 , wherein the slurry consists essentially of saline solution and bone particles.11. The surgical kit of claim 1 , wherein at least 90% of the bone particles have a characteristic size of 50 micrometers to 1000 micrometers.12. The surgical kit of claim 1 , wherein the bone ...

OCULAR INSERT APPARATUS AND METHODS

A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time. 1. A sustained release ocular drug delivery device for use with a human eye , the device comprising:a solid polymeric matrix core containing at least one therapeutic agent, the polymeric matrix core forming an annular segment; anda polymeric coating completely surrounding the annular segment of the polymeric matrix core, wherein the polymeric coating regulates the release of the at least one therapeutic agent from the polymeric matrix core,wherein the polymeric matrix core and polymeric coating are non-biodegradable in ocular fluids, andwherein the device forms a compliant ring-like structure that ranges from an arcuate C-shape having a gap distance extending between ends of the device to a full ring having a 360 degree circumference, andwherein a cross-sectional diameter of the ring-like structure ranges from 0.1 mm to 3.0 mm.2. The device according to claim 1 , wherein an inner diameter of the ring-like structure is at least 8 mm.3. The device according to claim 2 , wherein the inner diameter has a maximum diameter of about 30 mm.4. The device according to claim 1 , ...

INTRAOCULAR LENS

An intraocular lens includes a polymeric lens material formed from a polymerizable composition. The polymerizable composition includes: (a) a single aromatic acrylate monomer which is an aromatic-ring containing acrylate; (b) an alkoxyalkyl methacrylate monomer having an alkoxyalkyl group with 4 or less carbon atoms; (c) an alkyl acrylate monomer having an alkyl group with 1 to 20 carbon atoms; (d) a hydrophilic monomer; and (e) a crosslinkable monomer. 1. An intraocular lens comprising a polymeric lens material that is formed from a polymerizable composition comprising:(a) a single aromatic acrylate monomer which is an aromatic-ring containing acrylate;(b) an alkoxyalkyl methacrylate monomer having an alkoxyalkyl group with 4 or less carbon atoms;(c) an alkyl acrylate monomer having an alkyl group with 1 to 20 carbon atoms;(d) a hydrophilic monomer; and(e) a crosslinkable monomer.2. The intraocular lens according to claim 1 , wherein:the single aromatic acrylate monomer, the alkoxyalkyl methacrylate monomer, and the alkyl acrylate monomer constitute a base material of the polymerizable composition, and from 55 parts to 65 parts by mass of the single aromatic acrylate monomer;', 'from 10 parts to 25 parts by mass of the alkoxyalkyl methacrylate monomer;', 'from 15 parts to 30 parts by mass of the alkyl acrylate monomer;', 'from 15 parts to 30 parts by mass of the hydrophilic monomer; and', 'from 2 parts to 4 parts by mass of the crosslinkable monomer., 'the polymerizable composition comprises, per 100 parts by mass of the base material3. The intraocular lens according to claim 2 , wherein:the single aromatic acrylate monomer is phenoxyethyl acrylate,the alkoxyalkyl methacrylate monomer is ethoxyethyl methacrylate,the alkyl acrylate monomer is ethyl acrylate.4. The intraocular lens according to claim 3 , wherein the hydrophilic monomer is 2-hydroxyethyl methacrylate.5. The intraocular lens according to claim 1 , wherein the polymerizable composition comprises:35 mol ...

LIGHT-ADJUSTABLE HYDROGEL AND BIOANALOGIC INTRAOCULAR LENS

A bioanalogic implantable ophthalmic lens (“BIOL”) capable of replacing the natural crystalline lens (NCL) in its various essential functions after the NCL having been removed and BIOL implanted into the posterior eye chamber and placed into the capsular bag vacated from the NCL. At least the posterior surface of the lens has a convex shape and is made from a transparent flexible hydrogel material. At least the anterior and posterior optical surfaces are defined by rotation of one or more conic sections along the main optical axis and the surfaces defined by the rotation will include a plane perpendicular to the axis and conical surface symmetrical by the axis. A hydrogel implantable ophthalmic lens whose optical parameters can be optimized and/or customized by a controlled absorption of electromagnetic radiation resulting in a change of the refractive index of the irradiated hydrogel. 1. An in situ-adjustable ophthalmic implant comprising a hydrogel wherein said hydrogel comprises an acrylate or a methacrylate copolymer hydrogel wherein said copolymer comprises at least four co-monomers:a) an acrylate ester or a methacrylate ester, each containing at least one pendant hydroxyl group;b) a polyol acrylate ester, a polyol acrylate amide, a polyol methacrylate ester, or a polyol methacrylate amide, each with at least 2 acrylate or methacrylate groups per polyol ester or amide;c) acrylic or methacrylic acid, or a derivative thereof, each having at least one pendant carboxyl group; andd) a vinyl monomer, an acrylic monomer, or a methacrylic monomer, each having a pendant UV-absorbing group;wherein refractive properties of said implant are adjustable by absorption of femtosecond laser pulses by said hydrogel resulting in a negative change of refractive index in selected locations of said implant.2. The ophthalmic implant according to claim 1 , wherein the implant has anterior and posterior refractive surfaces forming a lens with positive or negative refractive power.3. ...

FUNCTIONALLY GRADED POLYMER KNEE IMPLANT FOR ENHANCED FIXATION, WEAR RESISTANCE, AND MECHANICAL PROPERTIES AND THE FABRICATION THEREOF

The present invention comprises a polymeric based femoral and/or tibial component implant to be used in total knee replacement/arthroplasty procedures serving to provide increased wear resistance, enhanced physiological response at the bone/implant interface, and decreased stress-shielding. The implant can be made via additive manufacturing. The articulating surface of the implant may be implemented in without any additive or in a form containing an additive for improved tribological response. Further, the device disclosed herein contains an interfacial surface which is in contact with the native bone (i.e., bone/implant interface) which may exist in its pure form, containing a bioactive additive. The implant has a porous morphology on the bone/implant interface for improved biological response and improved fixation. The depth of the additives and the topographical morphology therein are controlled via techniques disclosed herein. 1. A polymeric-based knee implant comprising an articulating surface and a bone/implant interface; wherein the bone/implant interface is porous; and wherein the implant has a polymeric material comprising a PAEK species (PEEK , PEKK , PEKEKK , etc.) or a PE species (PE , HDPE , UHMWPE , XL-PE , Vit-E-PE).2. The polymeric-based knee implant of claim 1 , wherein the porous bone/implant interface has a pore size of from 0.1 mm to 10 mm.3. The polymeric-based knee implant of claim 1 , wherein the bone/implant interface comprises bioactive additives.4. The polymeric-based knee implant of claim 1 , wherein the articulating surface comprises a high wear resistant bioinert composition.5. The polymeric-based knee implant of claim 1 , wherein the implant further comprises fixation pegs.6. The polymeric-based knee implant of claim 1 , consisting of one or more components claim 1 , wherein at least one component of the implant comprises a bioinert polymer.7. The polymeric-based knee implant of claim 1 , wherein the one or more components comprises a ...

INTERVERTEBRAL DISC PROSTHESIS MADE FROM THERMOPLASTIC MATERIAL HAVING GRADUATED MECHANICAL PROPERTIES

An intervertebral disc prosthesis comprises a structure having a rigid upper plate, a rigid lower plate, and a core inserted between said plates, the structure being made from thermoplastic material, the core further comprising a thermoplastic monomaterial having graduated elastic and damping properties. According to one alternative, the core is composed of an elastomeric central nucleus surrounded by one or more rings which are referred to as rings having ranks j relative to the core, and which are more rigid. 1. An intervertebral disc prosthesis comprising: a structure having a rigid upper plate , a rigid lower plate , and a core inserted between said plates , the structure being made from thermoplastic material , the core further comprising a thermoplastic monomaterial having graduated elastic and damping properties.2. The intervertebral disc prosthesis as claimed in claim 1 , wherein the structure has a graduated thickness from one end to the other claim 1 , which gives it a wedge shape claim 1 , the front being thicker than the rear.3. The intervertebral disc prosthesis as claimed in claim 1 , wherein the rigid upper and lower plates are composed of a mixture of polyethylenes comprising at least 50% by weight of high density polyethylene (HDPE).4. The intervertebral disc prosthesis as claimed in wherein the rigid upper and lower plates are composed 100% of high density polyethylene (HDPE) polymer.5. The intervertebral disc prosthesis as claimed in claim 1 , wherein said core is composed of an elastomeric central nucleus surrounded by one or more rings which are rings having ranks j relative to the core claim 1 , and which are more rigid.6. The intervertebral disc prosthesis as claimed in claim 1 , wherein the central nucleus represents at least 20% of the volume of the core.7. The intervertebral disc prosthesis as claimed in claim 1 , wherein the central nucleus is composed of:50 to 100% by weight of ultra low density polyethylene (ULDPE), and0 to 50% by weight ...

FILLER FOR REMOVING WRINKLES

The present invention relates to a filler for removing wrinkles, which comprises: a thin and long tubular main body to be placed so as to penetrate through subcutaneous tissue; and through-holes for guiding tissue cells surrounding the main body into the main body, so as to form fibrous tissue, wherein the through-holes are formed so as to communicate with a hollow portion formed in said main body in the lengthwise direction from the outer surface of said main body. The filler for removing wrinkles according to the present invention is prevented from being deformed or moved by pressure on the skin or by an external force arising after being inserted into the subcutaneous tissue, and can be applied to various body parts having wrinkles, including deep wrinkles. Furthermore, the wrinkle-removing effects of the filler of the present invention may last (semi)permanently. 1. A method of removing skin wrinkles , the method comprising: wherein the filler comprises a thin and long tubular main body provided so as to be into the subcutaneous layer,', 'wherein the filler comprises through-holes provided so as to guide tissue cells surrounding the main body into a hollow portion to form fibrous tissue,', 'wherein the through-holes are formed to communicate with the hollow portion formed in the main body in a lengthwise direction from the outer surface of the main body,', 'wherein the filler has recoiling force so as to endure a pressure or external force applied on a skin without collapsing after being inserted into a subcutaneous layer,', 'wherein the main body is formed by spirally winding a plurality of strip-shaped parts so as to cross each other, such that the hollow portion is provided in the parts in a lengthwise direction, and the through-holes communicating with the hollow portion from the outer surface of the main body are provided by the gaps between the parts; and, 'inserting a filler for removing a skin wrinkle into a subcutaneous layer of a subject in need of ...

Macroinitiators for hydrophilic coatings on latex and applications thereof

Provided herein are methods comprising the use of a macroinitiator and application protocols to apply a hydrophilic coating to latex, or natural rubber, and compositions resulting from such methods. This coating results in e.g., an increased sense of lubrication when in contact with water or an aqueous solution.

Shape memory polymer

A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation.

A formulation and lens manufacturing process for the production of intraocular lens (iol)

This invention relates to a formulation and the lens manufacturing process in the areas of medicine, ophthalmology, cataracts and cataract surgery for the production of mainly intraocular lens (IOL) which is flexible, biocompatible and has long-shelf life.

CARBAMATE, THIOCARBAMATE OR CARBAMIDE COMPRISING A BIOMOLECULAR MOIETY

Compounds are provided which comprise (a) at least two polymerisable moieties, (b) at least one amino acid residue of an amino acid comprising at least two amine groups of which at least two amine groups have formed a carbamate, a thiocarbamate or a carbamide group, and (c) a biomolecular moiety linked directly or via a spacer to the carboxylic acid moiety of the diamino acid residue or a carboxylic acid to which such moiety can be linked. A polymer obtained from such compounds is also disclosed. 1. A formulation comprising:(a) a polymerizable compound comprising (a) at least two radically polymerizable moieties comprising an acrylate, an alkylacrylate, a methacrylate, an alkylmethacrylate, a vinylether, a fumarate, a vinylsulphone, or an itaconate, (b) at least one amino acid residue of an amino acid, the amino acid comprising at least two amine groups, and (c) a biomolecular moiety Z linked directly or via a spacer to the amino acid residue via a carboxylic acid moiety of the amino acid, wherein the polymerizable compound comprises at least two carbamate groups, at least two carbamide groups, or at least one carbamate group and at least one carbamide group, wherein the at least two carbamate groups, at least two carbamide groups, or at least one carbamate group and at least one carbamide group result from the reaction of an amine group of the amino acid with one or more other compounds; and(b) a photo-initiator.2. The formulation according to claim 1 , wherein the polymerizable compound further comprises a polyester claim 1 , a polythioester claim 1 , a polyorthoester claim 1 , a polyamide claim 1 , a polythioether claim 1 , a polyanhydride claim 1 , a polydioxanone claim 1 , or a polycarbonate moiety.3. The formulation according to claim 1 , further comprising (c) a further polymerizable compound comprising a polymerizable moiety comprising an acrylate claim 1 , an alkylacrylate claim 1 , a methacrylate claim 1 , an alkylmethacrylate claim 1 , a vinylether claim ...