Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens

A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.

MOULD MAT FOR PRODUCING BONE CEMENT PELLETS

A means to prepare bone cement pellets comprising bone cement paste which hardens through hydration a flexible mould mat having pellet cavities on both sides and a scraper for pasting the bone cement paste in to the pellet cavities where the paste is allowed to harden. 1. A mould mat containing cavities wherein the size , spacing and geometric arrangement of cavities is such that any straight line drawn along the full length of the mould mat parallel to an edge of the mould mat in at least one direction and within the arrangement of cavities on the mat will always intersect at least one cavity.2. A mould mat according to wherein any row of cavities within the arrangement of cavities has a diagonal offset of about 30 degrees.3. A mould mat according to wherein any row within the arrangement of cavities has a diagonal offset of about 20 degrees.4. A mould mat according to wherein the mould mat contains pellet cavities on both sides thereof.5. A mould mat according to wherein the mould mat contains pellet cavities of different diameters or shapes on either side thereof.6. A mould mat according to where the cavities are cylindrical in shape.7. A mould mat according to wherein the cylindrical cavities in the mould mat are between about 2 mm to about 8 mm diameter.8. A mould mat according to where the cavities are hemispherical in shape.9. A mould mat according to wherein the hemispherical cavities are between about 2 mm to about 8 mm in diameter.10. A mould mat according to wherein the cavities are cylindrical cavities having a hemispherical closed end.11. A mould mat according to wherein the cylindrical cavities with a hemispherical closed end on the first side are between about 2 mm to about 8 mm in diameter.12. A mould mat according to wherein the mould mat is substantially rectangular in shape.13. A mould mat according to wherein the thickness of the mould mat is between about 6 mm to about 12 mm.14. A mould mat according to wherein the width of the mould mat is ...

Multi-Layered Graft for Tissue Engineering Applications

A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided. 1. A method of making a synthetic tubular graft device , comprising:depositing an ECM gel layer over a first tubular, porous, biodegradable polymer matrix; anddepositing a second tubular, porous, biodegradable polymer matrix over the ECM gel to produce a tubular structure.2. The method of claim 1 , wherein the first tubular claim 1 , porous claim 1 , biodegradable polymer matrix is a dry-electrospun matrix.3. The method of claim 1 , wherein the ECM gel is prepared from vascular tissue.4. The method of claim 1 , wherein the second tubular claim 1 , porous claim 1 , biodegradable polymer matrix is prepared by phase separation.5. The method of claim 1 , wherein the first tubular claim 1 , porous claim 1 , biodegradable polymer matrix and/or the second tubular claim 1 , porous claim 1 , biodegradable polymer matrix comprises one or more of: poly(lactic acid) (PLA); poly(trimethylene carbonate) (PTMC); poly(caprolactone) (PCL); poly(glycolic acid) (PGA); poly(glycolide-co-trimethylenecarbonate) (PGTMC); poly(L-lactide-co-glycolide) (PLGA); polyethylene-glycol (PEG-) containing block copolymers; polyphosphazene; poly(ester urethane) urea (PEUU); poly(ether ester urethane)urea (PEEUU); poly(ester carbonate)urethane urea (PECUU); poly(carbonate)urethane urea (PCUU); a polyurethane; a polyester; a polymer comprising monomers derived from alpha-hydroxy acids such as: polylactide claim 1 , poly(lactide-co-glycolide) claim 1 , poly(L-lactide-co-caprolactone) claim 1 , polyglycolic acid claim 1 , poly(dl-lactide-co-glycolide) claim 1 , and/or poly(-lactide-co-dl-lactide); a polymer comprising monomers derived from esters including polyhydroxybutyrate claim 1 , polyhydroxyvalerate claim 1 , polydioxanone claim 1 , and ...

Self-Lubricating Medical Articles

Medical articles formed from a polyurethane-based resin including a modifying oligomer provide enhanced properties. A modifying oligomer incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by a diisocyanate, a polyglycol, and a diol chain extender has at least one, preferably two, alcohol moieties (C—OH) and a functional moiety. Exemplary modifying oligomers are: a diol-containing perfluoropolyether incorporated into the backbone, a monofunctional polysiloxane (e.g., monodialcohol-terminated polydimethylsiloxane) incorporated as the side chain, and combinations thereof. Medical articles herein are self-lubricating and/or anti-fouling. 1. A medical article formed from a polyurethane-based resin , which is a reaction product of the following ingredients:a diisocyanate;a diol chain extender;a polyglycol; anda modifying oligomer comprising a diol-containing perfluoropolyether, the diol-containing perfluoropolyether being incorporated into a backbone of the polyurethane-based resin formed by the diisocyanate, the polyglycol, and the diol chain extender;wherein the medical article is effective as a self-lubricating and/or self-anti-fouling medical article.2. The medical article of claim 1 , wherein a concentration of the perfluoropolyether at a surface of the medical article is higher than a theoretical concentration of the perfluoropolyether based on uniform distribution of the ingredients.3. The medical article of claim 1 , wherein a hard segment content is in the range of from 25% to 75% by weight and a soft segment content of the resin is in the range of from 75% to 25% by weight.4. The medical article of claim 1 , wherein the perfluoropolyether is present in a soft segment of the polyurethane-based resin in a backbone in an amount in the range of from 0.1 to 10% by weight of the overall resin composition.5. The medical article of claim 1 , wherein the modifying oligomer further includes a monofunctional polysiloxane claim 1 , ...

CHARGED GRAFTS AND METHODS FOR USING THEM

A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve. 1. A system for preventing at least one of infection , thrombosis , and undesired tissue growth in an implantable medical device , comprising:an implantable medical device sized for implantation at least partially within a patient's body, the device comprising an at least partially electrically conductive portion that is disposed within a patient's body upon implantation; anda power source coupled to the electrode for providing an electric charge to the at least partially electrically conductive portion.234-. (canceled)35. A method for preventing thrombosis on an implantable device in a body , the method comprising:implanting the device within a patient's body, the device comprising an at least partially electrically conductive portion, and a power source coupled to the at least partially electrically conductive portion; andapplying a negative electrical charge to the at least partially electrically conductive portion for an indefinite time to prevent thrombosis adjacent the at least partially electrically conductive portion.36. The method of claim 35 , wherein implanting the device comprises:implanting an ...

Inhibition of Platelet Absorption

A cardiovascular graft is provided with highly reduced thrombogenicity. The cardiovascular graft is an electrospun non-woven mesh produced from supramolecular polymers with large diameter fibers. The cardiovascular graft can be implemented as a vascular graft into the human body to allow vascular bypass/reconstruction, or repeated venous access for dialysis treatment, as well as other disorders of small-diameter blood vessels. 1. A method of using a cardiovascular graft to reduce thrombogenic effects , comprising:having a cardiovascular graft designed as a tubular structure with an inner wall made out of a fibrous network of supramolecular compounds having hard-blocks covalently bonded with soft-blocks, wherein the hard-blocks comprise 2-ureido-4[1H]-pyrimidinone (UPy) compounds, wherein the fibrous network is a bioresorbable electrospun non-woven fibrous network with fibers having an average fiber diameter of 1-10 microns, and wherein the tubular structure has an inner diameter between 2-8 mm, and an inner wall thickness of 20-900 micrometers; andusing the cardiovascular graft to reduce thrombogenic effects upon implantation of the cardiovascular graft in a human body.2. The method as set forth in claim 1 , further comprises administering an an αβinhibitor in combination with the implantation of the cardiovascular graft.3. The method as set forth in claim 1 , wherein the inner wall has a thickness of at least 200 micrometers and has pores with an average pore size between 5 and 10 micrometers.4. The method as set forth in claim 1 , wherein the inner wall has pores with an average pore size between 5 and 8 micrometers and an average porosity ranging from 50 to 80%.5. The method as set forth in claim 1 , wherein the tubular structure has an inner diameter between 3-6 mm and a wall thickness of 200-800 microns.6. The method as set forth in claim 1 , wherein the tubular structure has an inner diameter between 4-8 mm and an inner wall thickness of 300-900 microns.7. The ...

LEFT ATRIAL APPENDAGE CLOSURE DEVICE WITH ANTI-THROMBOGENIC COVERING

Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh. 1. A left atrial appendage device , comprising:an expandable frame configured to shift between a first configuration and an expanded configuration;a fabric mesh disposed along at least a portion of the expandable frame; andan anti-thrombogenic coating disposed along the fabric mesh.2. The left atrial appendage device of claim 1 , wherein the fabric mesh includes a plurality of filaments.3. The left atrial appendage device of claim 2 , wherein the plurality of filaments include polyethylene terephthalate.4. The left atrial appendage device of claim 2 , wherein the plurality of filaments include polyester.5. The left atrial appendage device of claim 2 , wherein the anti-thrombogenic coating encapsulates at least some of the plurality of filaments.6. The left atrial appendage device of claim 2 , wherein the anti-thrombogenic coating individually coats each of the plurality of filaments.7. The left atrial appendage device of claim 2 , wherein the plurality of filaments are arranged as non-woven configuration.8. The left atrial appendage device of claim 2 , wherein the plurality of filaments are arranged into a fiber bundle.9. The left atrial appendage device of claim 8 , wherein the anti-thrombogenic coating migrates to an interior region of the fiber bundle.10. The left atrial appendage device of claim 1 , wherein the anti-thrombogenic coating includes a fluoropolymer.11. The left atrial appendage device of claim 1 , wherein the anti-thrombogenic coating includes polyvinylidene fluoride.12. The left atrial appendage device of ...

PELLET-SHAPED COMPOSITION FOR MEDICAL USE, AND MOLDED PRODUCT

A problem that the present invention is to solve is to provide a pellet-shaped composition for medical use mainly comprising a polyvinyl chloride resin and exhibiting antithrombotic property when merely being molded. 1. A pellet-shaped composition for medical use which comprises 1 to 120 part(s) by weight of a plasticizer and 0.01 to 5 part(s) by weight of a (meth)acrylate copolymer containing a hydrophobic (meth)acrylate unit and a hydrophilic (meth)acrylate unit to 100 parts by weight of a polyvinyl chloride resin , wherein number-average molecular weight of the (meth)acrylate copolymer is 7 ,000 to 50 ,000.4. The pellet-shaped composition for medical use according to claim 1 , wherein number-average polymerization degree of the polyvinyl chloride resin is 700 to 3 claim 1 ,000.5. The pellet-shaped composition for medical use according to claim 1 , wherein the plasticizer is one or more member(s) selected from di-2-ethylhexyl phthalate (DOP) claim 1 , tri-2-ethylhexyl trimellitate (TOTM) and diisononyl cyclohexane-1 claim 1 ,2-dicarboxylate (DINCH).6. A molded product prepared by melt molding the pellet-shaped composition for medical use mentioned in .7. A tube for medical use prepared by melt molding the pellet-shaped composition for medical use mentioned in . The present invention relates to a pellet-shaped composition for medical use which can be suitably used for main tube, etc. constituting a blood circuit for artificial dialysis or heart-lung apparatus. More particularly, it relates to a pellet-shaped composition for medical use which contains a polyvinyl chloride resin, a plasticizer and a copolymer of hydrophobic (meth)acrylate with hydrophilic (meth)acrylate and which can manufacture a medical material exhibiting excellent antithrombotic property and transparency.In recent years, investigations for medical materials utilizing various kinds of synthetic polymer materials have been carried out. Such medical materials have been utilized for blood filters, ...

Catheter lock solution formulations

A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial.

METHOD FOR PRODUCING ANTITHROMBOTIC COATING MATERIAL

Provided is a method for producing an antithrombotic coating material in which a high molecular weight polymer can be obtained by a solution polymerization using a radical polymerization initiator. The above-mentioned task is achieved by a method for producing an antithrombotic coating material, including steps of: preparing a methanol solution containing a monomer represented by formula (1): 2. The method according to claim 1 , wherein a content of the monomer contained in the polymerization reaction liquid is 10 wt % or more.3. The method according to claim 2 , wherein the content of the monomer contained in the polymerization reaction liquid is from 20 wt % to a saturated concentration.4. The method according to claim 1 , wherein a weight average molecular weight of the polymer obtained by the polymerization of the monomer is 200 claim 1 ,000 or more.5. The method according to claim 4 , wherein the weight average molecular weight of the polymer obtained by the polymerization of the monomer is more than 300 claim 4 ,000 but not more than 1 claim 4 ,000 claim 4 ,000.6. The method according to claim 1 , wherein the monomer is methoxyethyl (meth)acrylate.7. The method according to claim 1 , wherein the methanol solution contains methanol in an amount of 95 wt % or more claim 1 , based on the total solvent content of the methanol solution.8. The method according to claim 1 , wherein the monomer is methoxymethyl acrylate claim 1 , methoxyethyl acrylate (MEA) claim 1 , ethoxymethyl acrylate claim 1 , ethoxyethyl acrylate claim 1 , methoxymethyl methacrylate claim 1 , methoxyethyl methacrylate claim 1 , ethoxymethyl methacrylate claim 1 , or ethoxyethyl methacrylate.9. The method according to claim 1 , wherein the monomer represented by formula (1) is copolymerized with a second monomer that is copolymerizable with the monomer represented by formula (1).10. The method according to claim 1 , wherein the radical polymerization initiator having a 10-hour half-life ...

METHODS FOR DIFFERENTIATING ISCHEMIC STROKE FROM HEMORRHAGIC STROKE

The invention relates to a method for differentiating ischemic stroke from hemorrhagic stroke in a patient and to a method for selecting a patient suffering stroke for a therapy with an antithrombotic agent or with an agent capable of reducing blood pressure based on the determination of the level of GFAP in a sample of said patient in combination with one or more markers selected from the group consisting of NEF3, β-synuclein, CARNS1 and RBP4, or based on determining the level of RBP4 in a sample of said patient. Furthermore, the invention relates to a kit comprising a reagent for detecting the level of a marker selected from GFAP NEF3, β-synuclein, CARNS1, RBP4 or a combination thereof and to the use of the said kit in the methods of the invention.

COATING COMPOSITIONS, POLYMERIC COATINGS, AND METHODS

A coating composition comprises an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer, wherein the at least one neutral monomer has a glass transition temperature of less than about 100° C. in homopolymeric form. A device comprises a protonated polyacrylate coating, wherein the device is inherently antimicrobial, anti-thrombogenic, flexible, and/or sheds few to no particulates. 1. A coating composition comprising an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer , wherein the at least one neutral monomer has a glass transition temperature of less than about 100° C. in homopolymeric form.2. The coating composition of claim 1 , wherein the vinyl carboxylic acid monomer is selected from the group consisting of acrylic acid claim 1 , 2-bromoacrylic acid claim 1 , 2-(bromomethyl) acrylic acid claim 1 , 2-carboxyethyl acrylate claim 1 , 2-ethylacrylic acid claim 1 , itaconic acid claim 1 , methacrylic acid claim 1 , 2-propylacrylic acid claim 1 , sodium acrylate claim 1 , sodium methacrylate claim 1 , 2-(trifluoromethyl) acrylic acid claim 1 , 4-vinylbenzoic acid claim 1 , and combinations thereof and wherein the neutral monomer is selected from the group consisting of acrylates claim 1 , methacrylates claim 1 , acrylamides claim 1 , methacrylamides claim 1 , vinyl compounds claim 1 , and combinations thereof.3. The coating composition of claim 1 , wherein the neutral monomer has a glass transition temperature of less than about 90° C. claim 1 , 80° C. claim 1 , 70° C. claim 1 , 60° C. claim 1 , 50° C. claim 1 , 40° C. claim 1 , 30° C. claim 1 , 20° C. claim 1 , or 10° C. in homopolymeric form and wherein a copolymer formed from the polymerization of the at least one vinyl carboxylic acid monomer and the at least one neutral monomer has a glass transition temperature that is lower than about 100° C.4. A polymeric coating comprising a copolymer graft-polymerized ...

COATING AGENTS AND COATED ARTICLES

The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by 139-. (canceled)40. A method for forming a coated article , the method comprising steps of (a) applying a base coating composition to a surface of the article , the base coating composition comprising a polymer that includes a polymaleic acid derivative or a copolymer of a polymaleic acid derivative , one or more photoreactive groups that are pendent from the polymer , and one or more siloxane groups; and (b) exposing the base coating composition to actinic energy , thereby activating at least some of the photoreactive groups and covalently coupling the base coating composition on the surface.41. The method according to wherein the surface of the article is not pretreated by chemical claim 40 , biological or physical pretreatments that generate reactive groups on the surface prior to applying the base coating composition to the surface.42. The method according to further comprising a step of applying one or more overcoat layers onto the base coating composition.43. The method according to wherein step (a) comprises applying a base coating composition comprising a polymer that includes a polymaleic acid derivative or a copolymer of a polymaleic acid derivative claim 40 , one or more photoreactive groups that are pendent from the polymer claim 40 , and one or more amide siloxane groups.44. The method according to further comprising a step of disposing an active agent coating layer on the base coating composition.45. The method according to wherein the step of disposing an active agent coating layer is performed after step (b).46. A coated article prepared by the method of wherein the base coating composition does ...

METHOD FOR PRODUCING MEDICAL DEVICE AND MEDICAL DEVICE

Provided is a method for preparing a medical device which has a surface lubricating layer on a surface of a substrate and the surface of which exhibits lubricity and antithrombotic qualities when being wet. The method includes forming a coating layer that contains a hydrophilic polymer having at least one reactive functional group selected from the group consisting of an epoxy group, an acid chloride group, and an aldehyde group, and then applying onto the coating layer an antithrombotic material solution that contains an antithrombotic material having a functional group capable of binding to the hydrophilic polymer to form the surface lubricating layer. The concentration of the antithrombotic material in the antithrombotic material solution is more than 0 and less than 0.1 wt %. 1. A method for producing a medical device comprised of a surface lubricating layer on a surface of a substrate , in which the surface lubricating layer exhibits lubricity and antithrombotic qualities when being wet , the method comprising:forming onto the substrate a coating layer that contains a hydrophilic polymer having at least one reactive functional group selected from the group consisting of an epoxy group, an acid chloride group, and an aldehyde group;applying onto the coating layer an antithrombotic material solution that contains an antithrombotic material having a functional group that binds to the hydrophilic polymer to form the surface lubricating layer;the antithrombotic material in the antithrombotic material solution being present in a concentration more than 0 wt % and less than 0.1 wt %.2. The method for producing a medical device according to claim 1 , wherein the antithrombotic material has a sulfonate group or a sulfate group.3. The method for producing a medical device according to claim 2 , wherein the antithrombotic material contains a repeating unit derived from a monomer selected from the group consisting of 2-(meth)acrylamido-2-methyl-propanesulfonic acid claim 2 ...

Biocompatibility of solid surfaces

An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylizine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.

心血管移植片

【課題】血栓形成性が大幅に低下した心血管移植片を提供する。【解決手段】柔らかいブロックと共有結合した硬いブロックを有する超分子化合物の繊維状ネットワークで作られた内壁を備える管状構造を含み、前記硬いブロックは、２－ウレイド－４［１Ｈ］－ピリミジノン（ＵＰｙ）化合物を含み、前記繊維状ネットワークは、平均繊維径が１～１０μｍの繊維を有する生体吸収性の電界紡糸不織繊維ネットワークであり、前記管状構造は、２～８ｍｍの内径と、２００～９００μｍの壁厚を有し、前記繊維は、前記管状構造において長手方向の軸を中心とした周方向に、前記周方向の線形弾性剛性と前記周方向に垂直な方向の線形弾性剛性との比が１：２～２未満：１となるように整列していることを特徴とする心血管移植片を提供する。【選択図】図６

Method for manufacturing medical device and medical device

A kind of hirudin is modified the preparation method of anticoagulant material

本发明涉及生物医用材料制备技术领域，具体涉及一种水蛭素改性抗凝血材料的制备方法。本发明将蜘蛛提取液、壳聚糖、桑黄多糖、葡萄糖等混合得到诱导液，将诱导液灌入猪小肠中，用宽体金线蛭吸吮诱导液增重，挤压出宽体金线蛭唾液得到纯化滤液，将丝素蛋白溶液、明胶液、盐酸四环素、纯化滤液混合、超滤得到浓缩液，最后经过冷冻干燥得到水蛭素改性抗凝血材料，明胶液中含有多种蛋白质和维生素，能对基体起到补充营养的作用，鱼鳞所含的不饱和脂肪酸，可以抑制血液中血蛋白的氧化，从而避免发生凝血效应，水蛭素能抗凝血、抗血栓形成，还能抑制凝血酶诱导的成纤维细胞的增殖和凝血酶对内皮细胞的刺激，应用前景广阔。

Coating for biomaterial and its use

Coating for biomaterial

The term biomaterial is generally applied to describe a material which can be introduced into the bloodstream or the tissue of the human body, for example infusion, cardiac or balloon-tipped catheters, electrodes for pacemakers or defibrillators, suture material, vascular prostheses, supportive structures for vessels, so-called stents or the like. It is known to coat such biomaterials in order to prevent, in particular, deposition of plasma and cell constituents and hence coagulation. According to the invention, a lacquer-like coating of a blood- and tissue-compatible material having a layer thickness below 100 micrometers, preferably 10 micrometers, is built up and is permanently degraded in the body. Any depositing plasma or cell constituents are liberated upon degradation of this coating material. Moreover, anticoagulants and anti-inflammatory substances may be incorporated in the coating material.

Directional drug delivery stent and method of use.

Anticoagulation material and preparation method and application thereof

本发明公开了一种抗凝材料及其制备方法。将动物组织脱细胞处理后，冻干、粉碎、胃蛋白酶进一步消化，之后使用特定浓度PBS处理，后处理得到抗凝材料。本发明一些实例的抗凝材料，具有良好的生物相容性和抗凝性能，制备工艺更为简单，成本低。本发明一些实例的制备方法，不需要进行交联处理，操作简便，成功率高，用时短。

A functional implantable medical device

본 발명은 기능성 생체 이식형 의료기기에 관한 것으로서, 더욱 상세하게는 기존의 소수성 생분해성 폴리머에 친수성 성분인 히알루론산을 추가함으로써, 친수성의 기능성을 부여할 수 있고, 기존의 생분해성 및 비 생분해성 폴리머에 생선콜라겐, 미백물질(알부틴, 비타민) 또는 멜라닌 생성억제 물질을 추가함으로써, 기존의 단순한 생체 지지대 역할을 개선하여 미백효과의 기능성을 줄 수 있으며, 기존의 단순한 삽입하는 생체 이식형 의료기기의 제품을 개선하기 위하여, 피부재생을 유도하는 표피성장단백질(EGF)을 첨가함으로써, 피부재생의 기능을 줄 수 있고, 생분해성 고분자에 보톡스의 물질인 신경마비의 기능을 추가함으로써, 보톡스의 흘러내림을 개선함과 더불어 주름개선의 기능을 2중으로 줄 수 있으며, 주사침을 커브드(curved)로 제조함으로써, 진피층에 주사침의 삽입을 용이하게 하고, 기존의 단순한 생분해성 또는 비 생분해성 고분자의 단순한 인체 이식형 제품에 친수성의 기능성 추가 또는 미백기능의 추가 또는 세포재생 및 피부재생의 기능을 개선하여 기능성 필러, 기능성 수술용 봉합사, 기능성 barbed 봉합사, 기능성 말단 루프 barbed 봉합사, 기능성 슬라이스 봉합사, 기능성 메시(mesh), 기능성 앵커, 기능성 의료용 시트(sheet), 기능성 유착방지막, 기능성 성형재료 조직 지지대, 기능성 barbed suture, 기능성 지지돌기형 barbed suture에 적용할 수 있으므로 그 적용범위가 광범위한 효과가 있다.

FUNCTIONALIZED MEMBRANE FOR ENCAPSULATING CHAMBER OF CELLS PRODUCING AT LEAST ONE SUBSTANCE OF THERAPEUTIC INTEREST AND BIOARTIFICIAL ORGAN COMPRISING SUCH A MEMBRANE

The present invention relates to a functionalized semi-permeable membrane composed of a porous biocompatible support pretreated so as to increase the surface energy thereof and characterized in that it comprises at least two layers, each comprising a hydrophilic polymer and at least one biologically active molecule, and to the use thereof in particular for producing a bioartificial organ.

Anticoagulant, antibacterial, anti-adhesion, anti-inflammatory and lubricating copolymer coating material for surface of silicone rubber material and preparation method thereof

本发明提供一种用于硅橡胶材料表面的抗凝血、抗菌、防粘连、抗炎、润滑的共聚物涂层材料及其制备方法，该材料为聚电解质与活性酯形成的高分子共聚物；聚电解质为两性离子聚电解质，由磷铵、羧铵或磺铵两性离子单体聚合生成。本发明将制备聚电解质的单体与活性酯单体直接混合共聚，或先制备两种单体中一种单体的均聚物，以均聚物作为链转移剂，以另一种单体作为聚合单体，合成共聚物。本发明制备的共聚物涂层通过简单的涂层工艺即可键合在硅橡胶表面形成稳定的聚合物涂层；经改性后的硅橡胶材料表面粘附的细菌和微生物的数量和密度显著降低，抗凝血、抗菌、防粘连、抗炎症性能显著提高；硅橡胶表面高亲水，摩擦系数显著减小，润滑性能明显增强。

Surgical patches with a biological active agent

소염제, 항혈소판제, 항응혈제, 섬유소용해제, 세포 주기 억제제 및/또는 항증식제를 방출하는 외과용 패치가 기술된다.

Patent FR2187849A1

Multi-dimensional multi-density wrinkle remove suture

본 고안은 매끈한 봉합사의 표면에 가시모양의 돌기를 만듦으로서 시술하는 의사가 원하는 위치에 서로 다른 강도로 원하는 정도만큼만 정확하게 당겨줄 수 있도록 한 다측면 다중밀도 주름제거용 봉합사에 관한 것이다. The present invention relates to a multi-sided multi-density wrinkle removal suture that allows the surgeon to draw exactly as much as desired with different strength at the desired position by making a spinous protrusion on the surface of the smooth suture. 이를 위해 본 고안은, 소정 길이의 의료용 봉합사(35)에서, 상기 봉합사(35)의 중앙부분을 기준하여 좌측 부위 및 우측 부위에 가시모양의 돌기(80a, 80b)(90a, 90b)가 상기 봉합사(35)의 외주면에 길이방향으로 형성되되, 상기 좌측 돌기(80a, 80b)와 우측 돌기(90a, 90b)는 중앙부분을 사이에 두고서 상호 대향되게 형성되고, 상기 좌측 돌기(80a, 80b)와 우측 돌기(90a, 90b)는 각각의 부위에서 180도의 각도로 연속적으로 형성되며, 상기 좌측 돌기(80a, 80b)와 우측 돌기(90a, 90b)는 중앙부분에서 멀어질수록 상호간의 간격이 좁아진다. To this end, the present invention, in the medical suture (35) of a predetermined length, based on the central portion of the suture (35) spine-like projections (80a, 80b) (90a, 90b) on the left side and the right side of the suture It is formed in the longitudinal direction on the outer circumferential surface of (35), the left projections (80a, 80b) and the right projections (90a, 90b) are formed to face each other with a central portion between, and the left projections (80a, 80b) and The right protrusions 90a and 90b are continuously formed at an angle of 180 degrees at each portion, and the distance between the left protrusions 80a and 80b and the right protrusions 90a and 90b is narrower from the center portion. .

Cardiovascular graft

Far infrared ray radiation suture line, manufacturing divece and method the same

본 발명은 내부 공간에 봉합사가 배치되는 고압탱크, 상기 고압탱크 내부의 압력을 7 내지 10kg/㎠까지 가압하고, 설정시간 경과 후 상기 고압탱크 내부의 압력을 대기압 이내로 감압하는 압력조절부, 원적외선을 방사하고 6.5㎛ 내지 1.3㎛의 입자 크기를 가지는 광물 파우더, 상기 광물 파우더를 수용하는 파우더 용기, 상기 파우더 용기 내부에서 상기 파우더를 교반하는 교반 블레이드, 상기 교반 블레이드를 회전시키는 교반 모터, 및 상기 파우더 용기 일측에서 상기 파우더 용기 내부의 상기 광물파우더에 전자기파를 조사하는 전자기파 방사부를 포함하고, 상기 고압탱크 내에 배치되는 원적외선 방사부, 및 상기 봉합사가 배치되고 상기 고압탱크 내부 공간으로 슬라이딩하여 들어가는 트레이, 상기 트레이를 회전시키는 트레이 회전 모터를 포함하는 봉합사 회전부를 포함하는 원적외선 방사 봉합사 제조 장치 및 방법과 그에 의해 제조된 원적외선 방사 봉합사를 제공한다. The present invention is a high pressure tank in which the suture is disposed in the inner space, the pressure inside the high pressure tank to 7 to 10kg / ㎠, and the pressure control unit for reducing the pressure in the high pressure tank within atmospheric pressure after a set time, far infrared rays Mineral powder that has a particle size of 6.5 μm to 1.3 μm, a powder container for accommodating the mineral powder, a stirring blade for stirring the powder inside the powder container, a stirring motor for rotating the stirring blade, and the powder container An electromagnetic radiation radiating unit for irradiating electromagnetic waves to the mineral powder inside the powder container at one side, a far-infrared radiating unit disposed in the high pressure tank, and the suture being disposed and sliding into the internal space of the high pressure tank, the tray Comprising a tray rotating motor for rotating the It provides a far infrared radiation suture manufacturing apparatus and method comprising a suture rotation unit and a far infrared radiation suture manufactured thereby.

Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens

A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.

Medical material and process for producing the same

Directional drug delivery stent

The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through directional delivery openings arranged on an outer surface of the elongated member. Another variation of the stent includes an osmotic engine assembly for controlling the delivery of the active agent from the reservoir. The drugs which may be applied by the directional delivery stent include, but are not limited to, steroids, anti-inflammatory agents, restenosis preventing drugs, anti-thrombotic drugs, and tissue growth regulating drugs. The invention also relates to a method of using the directional drug delivery stent.

Medical material and method for producing the same

Biocompatible material for medical apparatus comprising hydrophobically bound oil-soluble vitamin

A medical material which comprises an oil-soluble vitamin hydrophobically bound to a hydrophobic moiety containing macromer which is bound to the surface of a polymeric substrate via a copolymer is described. Suitable macromers include for example glycidyl methacrylate-linoleic acid. Suitable polymeric substrate materials include, in particular, cellulose. Methods for producing said medical material are also provided.

FUNCTIONALIZED MEMBRANE FOR ENCAPSULATING CHAMBER OF CELLS PRODUCING AT LEAST ONE SUBSTANCE OF THERAPEUTIC INTEREST AND BIOARTIFICIAL ORGAN COMPRISING SUCH A MEMBRANE

La présente invention se rapporte à une membrane semi-perméable fonctionnalisée composée d'un support biocompatible poreux préalablement traité pour en augmenter l'énergie de surface et caractérisée en ce qu'elle comprend au moins deux couches comprenant chacune un polymère hydrophile et au moins une molécule biologiquement active, et à son utilisation notamment pour la fabrication d'un organe bioartificiel. The present invention relates to a functionalized semipermeable membrane composed of a porous biocompatible support previously treated to increase its surface energy and characterized in that it comprises at least two layers each comprising a hydrophilic polymer and at least one biologically active molecule, and its use especially for the manufacture of a bioartificial organ.

Medical articles made of blood compatible polymers

Storing blood in chlorine-free plastic container with antihemolytic agent

ABSTRACT OF THE DISCLOSURE A method is disclosed for storing blood for a period of days ln a container made of a blood-compatible polymer comprising a sterilizable, chlorine-free plastic material. The method comprises providing to said blood in said container a sufficient concentration of a dispersed dialkyl-phthalate in which said alkyl groups each contain 4 to 12 carbon atoms, to cause a reduced plasma hemoglobulin content of blood stored in contact there-with for 21 days, when compared with blood stored in contact with the same blood-compatible material free of said antihemolytic agent.

AV grafts with rapid post-operative self-sealing capabilities

The invention provides a self-sealing arteriovenous graft including a tube having a polymeric inner layer defining a lumen through which blood may flow and an outer textile layer. The outer textile layer is concentrically disposed about the inner layer. Furthermore, an intermediate self-sealing layer is concentrically positioned between the inner and outer layers. The self-sealing layer includes a biocompatible polymer.

Polymer emulsion with anticoagulation function and preparation method thereof

本发明涉及生物医用材料技术领域，具体公开了一种具有抗凝血功能的聚合物乳液及其制备方法，其特征在于，所述聚合物乳液为肝素用化学键接枝长链烷基的大分子乳化剂，所述大分子乳化剂在聚合物乳液中含量是共聚物结构单元总量的5~30%，聚合物的结构单元（按重量配比）为：亲水结构单元10~40%、疏水结构单元40~80%、交联剂单元1~10%。具有抗凝作用的肝素基团以乳液聚合反应乳化剂的形式包裹在聚合物颗粒表面，肝素上接枝的长链烷基融入聚合物大分子中并与大分子链缠绕，使肝素基团固定在聚合物上，发挥抗凝血功能。

Coating compositions, polymeric coatings, and methods

A coating composition comprises an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer, wherein the at least one neutral monomer has a glass transition temperature of less than about 100°C in homopolymeric form. A device comprises a protonated polyacrylate coating, wherein the device is inherently antimicrobial, anti-thrombogenic, flexible, and/or sheds few to no particulates.

Antithrombotic material

본 발명은 저용혈 독성에 대한 안전성이 높아져서, 장기간 지속적으로 높은 항혈전성을 발휘할 수 있는 항혈전성 재료를 제공하는 것을 목적으로 하고 있다. 본 발명은 알킬렌이민, 비닐아민, 알릴아민, 리신, 프로타민 및 디알릴디메틸암모늄클로라이드로 이루어지는 군에서 선택되는 화합물을 구성 모노머로서 포함하는 폴리머, 및 황원자를 포함하는 음이온성의 항응고 활성을 갖는 화합물을 포함하는 피복 재료와, 상기 피복 재료에 의해 표면이 피복된 기재를 구비하고, 상기 폴리머는 상기 기재와 공유 결합하며, 표면에 있어서의 X선 전자 분광법으로 측정한 전체 원자의 존재량에 대한 질소원자의 존재 비율이 6.0~12.0원자수%인, 항혈전성 재료를 제공한다. It is an object of the present invention to provide an anti-thrombogenic material which is highly safe against low-hemolytic toxicity and can exhibit high antithrombotic properties continuously for a long period of time. The present invention relates to a polymer comprising a compound selected from the group consisting of alkyleneimine, vinylamine, allylamine, lysine, protamine and diallyldimethylammonium chloride as constituent monomers, and a compound having an anionic anticoagulant activity Wherein the polymer is covalently bonded to the substrate, and the surface of the polymer is covalently bonded to the substrate, and the surface of the substrate is coated with the nitrogen The present invention provides an antithrombotic material having an atomic percentage of 6.0 to 12.0 atomic%.

Mould mat for producing bone cement pellets

The present invention provides a mould mat 1 and method for producing bone cement pellets. The mat 1 comprises a plurality of cavities 13 and their size, spacing and geometric arrangement is such that any straight line 14 drawn along the full length of the mould mat 1 parallel to an edge in at least one direction and within the arrangement of cavities 13 will always intersect at least one cavity 13. Preferably any row of cavities has a diagonal offset 17 of around 20 or around 30 degrees. The mould mat 1 may comprise pellet cavities 13 on both of its sides and the cavities 13 may have different shapes and sizes. The cavities 13 may be cylindrical, hemi-spherical or rectangular. A kit of parts comprising the mould mat 1 may further comprise a bone cement powder, mixing aqueous liquid, mixing bowl, mixing instrument and a device for filling cavities in the mould mat. A method of making bone cement pellets using this kit is also described.

Coating agents and coated articles.

La invención describe agentes de recubrimiento novedosos que incluyen un polímero, uno o más grupos reactivos latentes, y uno o más grupos de enlace no covalente, los grupos de enlace no covalente seleccionados para interaccionar con un sustrato al que se le aplica el agente de recubrimiento; los agentes de recubrimiento son útiles para proveer un recubrimiento que se puede funcionalizar adicionalmente (por ejemplo, aplicando capas de recubrimiento adicionales), o para proveer propiedades deseables a una superficie.

A self-cleaning porous layer to minimize thrombus formation on blood contacting devices

The invention relates to self-cleaning porous structures, e.g., layers or coatings, fabricated within, applied to, or deposited on a blood contacting surface of a medical device, to prevent activation and aggregation of platelets thereon. In certain embodiments, the layer or coating is composed of multi-layered fibers. The porous structure is fabricated within, applied to, or deposited on, such as to form a permeable wall on the blood contacting surface. The blood travels into the wall and subsequently back out (reversing back into the lumen) during a cardiac cycle. Reversal flow is controlled during the diastole phase such that the backward flow repels the platelets and prevents their activation and aggregation and therefore, minimizes thrombus formation.

Cyclodextrin compounds and methods of making and use thereof

Cyclodextrin polymers and cyclodextrins immobilized on a solid surface

Polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are disclosed. Compositions and methods for separating a molecular species, including but not limited to a biologically active protein, from a mixture, for the storage of protein factors and for the therapeutic biodelivery of protein factors which employ the polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are also disclosed.

Blood bag made of antihemolytic polymer

Blood storage method

Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable ester such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

Antithrombotic resin, antithrombotic tube, antithrombotic film and antithrombotic coat

ABSTRACT OF THE DISCLOSURE The invention presents an antithrombotic resin which is prepared by blending at least one type of antithrombotics, in polyurethane or polyurethane urea polymerized by using at least one type of polyether diol selected from the group consisting of polyol containing a polyoxyethylene group ex-pressed in formula (I) (I) (where n is a number-average degree of polymerization of 1 to 100) and polyol containing a polyoxytetramethylene group expressed in formula (II)

A kind of amphiphilic biology carbon complex and its preparation method and purposes with antibiosis anticoagulative

本发明公开了一种具有抗菌抗凝的两亲生物碳复合物膜及其制法和用途。本发明通过共价偶联方法以及静电吸附方法，分别制备了修饰了肝素的两亲生物碳材料以及负载纳米银的两亲生物碳材料，并将它们均匀掺杂到疏水性树脂中制备得到具有抗菌抗凝功能的复合物膜。本发明的复合物膜具有广谱抗菌性和抗血小板粘附性，不仅对革兰氏阳性菌和革兰氏阴性菌均有较强的抑制作用，而且有较强的抗血小板粘附的作用，在医用导尿管相关性感染的领域中有广泛的应用前景。本发明公开了其制法。

Sternotomy spacing device

A device and a method for keeping the sternal edges apart for the procedure of delayed sternal closure is disclosed in which one or more, specifically shaped struts or stents are insinuated horizontally between the edges of the open sternum, keeping the two edges of the divided sternum apart by a distance determined by the length of the middle bar of the device. The disclosed device has lateral ends which are manually engaged to the medial ends of the sternal edges, by an insinuating movement while the said lateral ends of the apparatus hold onto the medial portion of the sternal edges by a passive, cupping grip which can be further secured by anchoring sutures. The whole of the disclosed device is in the form of a single piece, without any moving parts, joints, screws or nuts & bolts. The present device provides a method and an instrument which occupies minimum inter-sternal space and provides maximum sub-sternal space for accommodating cardiac oedema.

BLOOD COMPATIBLE POLYMERS AND MEDICAL DEVICES MADE FROM SUCH POLYMERS

Patent TW203067B

Coating for biomaterial

Medical material and process for producing the same

本发明的药疗用材料，是在具有极性基的乙烯衍 生物的聚合物或共聚物中含有抗血小板剂的材料，由 于能持续地以有效浓度溶出抗血小板剂，因而具有高 的抗凝血性及防止因血小板的活性化而引起的血小 板损失的作用。

Implant material

An implant material comprising a porous base material wherein the voids are filled with a denatured albumin or a biodegradable polyester and the blood-contacting surface contains an antithrombotic substance. This material is excellent in antithrombotic activity and can introduce cells thereinto actively, so that it can inhibit thrombus formation for long and has an excellent patency even when used in making an artificial blood vessel having an inner diameter as small as less than 6 mm.

A kind of preparation method and application of super-branched polyimide anti-coagulation anti-bacterial material

本发明公开了一种超支化聚酰亚胺抗凝血抗菌材料的制备方法，属于化工材料领域。本发明用2‑甲基丙烯酰氧乙基磷酸胆碱对氨基封端的超支化聚酰亚胺的表面进行接枝改性，形成超支化聚酰亚胺薄膜，制备的HBPI‑MPC薄膜生物相容性，抗凝血性以及抗菌性都更好。

Directional drug delivery stent

Preparation method and application of anticoagulant and anti-adhesion poly (heptafluoro butyl acrylate) -polycaprolactone block polymer nanofiber membrane

本发明属于生物材料领域领域，具体涉及抗凝血抗粘附聚七氟丁基丙烯酸酯‑聚已内酯嵌段聚合物纳米纤维膜的制备方法及应用，该方法是指：采用2,2,3,3,4,4,4‑七氟丁基丙烯酸酯单体通过可逆加成断裂链转移法在聚己内酯大分子链端接入含氟聚合物链段形成聚七氟丁基丙烯酸酯‑聚己内酯嵌段聚合物，将聚七氟丁基丙烯酸酯‑聚己内酯嵌段聚合物静电纺丝即可得到聚七氟丁基丙烯酸酯‑聚已内酯嵌段聚合物纳米纤维膜，方法简单易行，制备的纳米纤维膜血液相容性好，抗凝血和抗粘附效果佳，在制备适用于接触血液的医疗敷料或支架中的具有巨大的应用前景。

Biocompatibility of solid surfaces

ABSTRACT An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.

Antithrombogenic, non-calcifying material and method of making articles for medical purposes

An antithrombogenic, non-calcifying, and elastic material on a basis of polyurethane, characterized by the addition of fatty-acid esters and optionally by the further addition of cross-linking agents that react with water.

Compound anticoagulant heparin coating microballoon and preparation method and application

本发明公开了一种复合肝素抗凝涂层用微球及制备方法与应用，运用该涂层用微球制备的复合肝素生物抗凝涂层液具有抗组织增生、抗炎性反应等功能，对于人造血管、血管支架、血管补片等植入器械在人体内减少血栓形成，降低术后并发症，提高产品的使用寿命至关重要。

Medical products with caffeic acid phenethyl ester and manufacturing method thereof

본 발명은 수술 시 이용되는 생분해성 또는 비 생분해성 의료용 제품의 항균성 및 안전성 증진을 위한 기술로서, 의료용 제품이 프로폴리스의 활동성분인 카페인산에스테르(caffeic acid phenethyl ester, CAPE)을 포함하도록 함으로써, 의료용 제품의 항균 및 항염성을 높이는 것은 물론, 인체 내에서 독성의 발현 여부를 시험을 통해 확인하여 생물학적 안전성을 확인하는 기술이다.

Cyclodextrin Compounds, Methods of Preparation and Use

Methods of inhibiting restenosis

METHOD AND CONTAINER FOR COLLECTING AND STORING BLOOD

Medical material and process for its preparation

Medisinsk materiale som omfatter en polymer eller kopolymer av et vinylderivat med en polar gruppe, idet polymeren eller kopolymeren inneholder et antiblodplatemiddel. Siden anti-blodplate- midlet kan oppløses kontinuerlig i en aktiv konsentrasjon, har materialet høy antikoagulerende aktivitet og inhibe- ringsvirkning når det gjelder blodplate- tap på grunn av aktivering av blodpla- ter.

Gas permeable thrombo-resistant coatings and methods of manufacture

The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability.

Av grafts with rapid post-operative self-sealing capabilities

The invention provides a self-sealing arteriovenous graft including a tube having a polymeric inner layer defining a lumen through which blood may flow and an outer textile layer. The outer textile layer is concentrically disposed about the inner layer. Furthermore, an intermediate self-sealing layer is concentrically positioned between the inner and outer layers. The self-sealing layer includes a biocompatible polymer.

Polyurethane based medical articles

Medical articles formed from a polyurethane-based resin including an ionically-charged modifier provide enhanced properties. The polyurethane-based resin is a reaction product of ingredients comprising: a diisocyanate; a diol chain extender; a polyglycol; and an ionically-charged modifier incorporated into a backbone, as a side chain, or both of the polyurethane-based resin. Embodiments include the ionically-charged modifier is a combination of anionic and cationic modifiers. Embodiments include the ionically-charged modifier is zwitterionic. Medical articles herein either have inherent antimicrobial and/or anti-fouling characteristics or can easily bond ionic active agents to provide desirable material properties, including antimicrobial, anti-fouling, and/or radiopacity.

Antithrombotic material

An antithrombogenic material includes a coating material containing: a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; and a base material whose surface is coated with the coating material; wherein the polymer is covalently bound to the base material; and an abundance ratio of nitrogen atoms to an abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on a surface of the base material is 6.0 to 12.0 atomic percent.

Bacteria repellent surfaces

ABSTRACT The present invention relates to the use of hydrophilic sur-faces in order to restrict the adhesion of bacteria on objects coming into contact with bacteria, such as objects within the food stuff industry, and within health care. The hydrophilic surface can be neutral or charged for electrostatic repulsion of bacteria present and/or proteins.

For the production of the mould pad of bone cement pellets

一种制备骨水泥颗粒的单元，所述单元包括通过水合作用硬化的骨水泥浆料、在两个侧面上具有颗粒腔体的柔性模具垫片以及用于将所述骨水泥浆料涂到所述颗粒腔体内的刮刀，在所述颗粒腔体中使所述浆料硬化。

Implantation materials

The present invention is implantation materials comprising an anti-thrombogenic material contained in the surface in contact with blood, of a porous substrate with its voids filled with denatured albumin or a biodegradable polyester. Since they are excellent in anti-thrombogenic property and allow the positive introduction of cells into the implantation materials, they can prevent thrombogenesis for long periods of time. Especially even if they are used as artificial small diameter blood vessels of less than 6 mm in inner diameter, they show excellent patency.

Insoluble objects for medical or surgical use, such as plasmaphoresis or renal dialysis membranes, probes and plasma purification supports havingan anti-inflammatory activity

ABSTRACT OF THE DISCLOSURE Insoluble objects for medical or surgical use, such as plasmaphoresis or renal dialysis membranes, probes and plasma purification supports, having an anti-inflammatory activity. These objects are made from polymer, such as polystyrene and polysaccharides and to them is given an anti-inflammatory activity by fixing groups which inhibit the activation of the complement system such as-CH2-COO-Na, -COONa, -COY, and with Y representing a radical derived from an amino acid. B 8658.3

Antithrombotic material

The present invention aims to provide an antithrombogenic material which is highly safe with its low hemolytic toxicity, and capable of maintaining high antithrombogenicity for a long period. The present invention provides an antithrombogenic material comprising: a coating material containing a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride, and an anionic compound containing a sulfur atom and having anticoagulant activity; and a base material whose surface is coated with the coating material; wherein the polymer is covalently bound to the base material, and the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy on the surface is 6.0 to 12.0 atomic percent.

Surgical patches with a biological active agent

Surgical patches are described which release an anti-inflammatory agent, an anti-platelet agent, an anticoagulant, a fibrinolytic agent, a cell-cycle inhibitor, and/or an anti-proliferative agent.

Treatment of tissue membrane dysfunction

(57)【要約】 タンパク質性および他の薬剤の異常透過、ならびにそれらの除去または他の解剖学的機能の浸透を導く、組織および器官膜の完全性の喪失を含む病変に適応可能な治療方法が開示される。このような欠損は、例えば、炎症性疾患、糖尿病などに直接的または間接的に関連する。この治療方法は、１分子当たり約10までの糖単位を有しそして１糖単位当たり少なくとも1.4個のアニオン性置換基を有する治療量のオリゴ糖、好ましくは環状オリゴ糖を処置する必要のある膜に投与する工程を包含する。好ましくは、アニオン性置換基は、強酸の残基である。

Implantation materials

ABSTRACT The present invention is implantation materials comprising an anti-thrombogenic material contained in the surface in contact with blood, of a porous substrate with its voids filled with denatured albumin or a biodegradable polyester. Since they are excellent in anti-thrombogenic property and allow the positive introduction of cells into the implantation materials, they can prevent thrombogenesis for long periods of time. Especially even if they are used as artificial small diameter blood vessels of less than 6 mm in inner diameter, they show excellent patency.

Patent FR2187849B1

Antithrombotic material

FIELD: medicine.SUBSTANCE: invention relates to the field of medicine, specifically to an antithrombotic material, which includes base material and coating material, wherein the coating material comprises: (I) a cationic polymer covalently bonded to the base material; (II) an anionic polymer and/or an anionic compound covalently bonded to cationic polymer (I); (III) a cationic polymer covalently bonded to an anionic polymer and/or anionic compound (II); and (IV) a compound with anticoagulant activity, which is heparin or a heparin derivative, and said compound is ionically bound to cationic polymer (III). Disclosed antithrombotic material is characterised by relative content of nitrogen atoms from 6.0 to 12.0 at% and relative content of sulphur atoms from 3.0 to 6.0 at% on the surface relative to the content of all atoms when measured by X-ray photoelectron spectroscopy (XPS), wherein the amount of heparin or heparin derivative on the surface, estimated based on activity against factor Xa after immersion in physiological saline for 30 minutes, is at least 30 mIU/cm.EFFECT: antithrombotic material is disclosed.7 cl, 3 tbl, 9 ex

BLOOD COMPATIBLE POLYMERS AND MEDICAL DEVICES MADE FROM SUCH POLYMERS

L'INVENTION CONCERNE L'INDUSTRIE DES MATIERES PLASTIQUES ET DU MATERIEL MEDICO-CHIRURGICAL. LE SANG CONSERVE AU CONTACT D'UNE COMPOSITION DE MATIERE PLASTIQUE CONSTITUEE DE POLYMERE SANS CHLORE COMPATIBLE AVEC LE SANG TEL QU'UN POLYESTER SOUPLE, NON TOXIQUE ET STERILISABLE, CONTENANT 5 A 70 EN POIDS D'UN PLASTIFIANT EXTRACTIBLE PAR LE SANG, TEL QUE LE PHTALATE DE DI(ETHYL-2 HEXYLE), PRESENTE UNE VITESSE D'HEMOLYSE ETONNAMMENT FAIBLE PAR RAPPORT A CELLE D'UN SANG CONSERVE DANS DES POLYMERES CORRESPONDANTS NE CONTENANT PAS DE PLASTIFIANT. APPLICATION NOTAMMENT AUX SACS DE CONSERVATION ET TRAITEMENT, TUBULURES ET AUTRES DISPOSITIFS MEDICAUX DESTINES A VENIR EN CONTACT AVEC LE SANG.

Blood compatible plastic devices

Wirkstoffhaltige thermoplastische polyurethane

Antithrombotic material

The present invention aims to provide an antithrombogenic material which is highly safe with its low hemolytic toxicity, and capable of maintaining high antithrombogenicity for a long period. The present invention provides an antithrombogenic material comprising: a coating material containing a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride, and an anionic compound containing a sulfur atom and having anticoagulant activity; and a base material whose surface is coated with the coating material; wherein the polymer is covalently bound to the base material, and the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy on the surface is 6.0 to 12.0 atomic percent.

Methods of inhibiting restenosis

Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.

Manufacturing method of silk suture comprising 4-hexylresorcinol processing step

본 발명은 4-헥실레조르시놀 용액으로 처리하는 단계를 통하여 생분해 속도가 증진된 실크 봉합사를 간단한 공정과정으로 제조할 수 있다.

Emulsioni a base di agente antiemolitico e metodo e mezzi per il loro impiego.

医療デバイス用のコーティング、コーティングを含んで成る医療デバイス、および被覆することを含む使用および方法、コーティングを含んで成る医療デバイス、コーティングを製造する方法、ならびに医療デバイスをコーティングするためのキット

医療デバイス用コーティングについて記載されている。コーティングは、表層と、任意のオプションでベース層とを含んで成り、表面層は、耐凝固基に結合したポリマー鎖を含んで成り、耐凝固基は、スルホン酸基、スルホンアミド基、スルファミン酸基、硫酸水素基、およびそれらの共役塩基から選択される。また、コーティングを含んで成る医療デバイス、ならびにコーティングおよび医療デバイスを含む使用および方法についても記載されている。

Coating compositions, polymeric coatings, and methods

A coating composition comprises an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer, wherein the at least one neutral monomer has a glass transition temperature of less than about 100°C in homopolymeric form. A device comprises a protonated polyacrylate coating, wherein the device is inherently antimicrobial, anti-thrombogenic, flexible, and/or sheds few to no particulates.

Left atrial appendage closure device with anti-thrombogenic covering

Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.

一种温度、炎症双响应性的抗凝复合涂层及其制备方法、应用

本发明提供了一种抗凝复合涂层，包括温敏基层以及复合在所述温敏基层上的炎症响应层；所述温敏基层具有聚合物网络结构；所述炎症响应层具有聚合物网络结构；所述温敏基层和炎症响应层之间通过聚合物实现化学键连。该涂层可以广泛应用于医用植介入材料等各类血液接触类材料，当涂层植入到体内后，一方面炎症响应性聚合物响应损伤造成的炎症分解，抗凝分子增强表面的抗凝能力；另一方面温敏基层响应人体温度加速抗炎药物释放，阻断炎症‑凝血的级联通路，进一步加强涂层的抗凝能力。本发明中的温度、炎症双响应性的抗凝复合涂层提高了医用植介入材料等各类血液接触类材料的抗凝能力与安全性，延长服役时间，涂层表现出优异的抗凝血效果。

ポリウレタンベースの医療用物品

イオン電荷を有する修飾剤を含むポリウレタンベースの樹脂から形成された医療用物品は、強化された特性を提供する。ポリウレタンベースの樹脂は、ジイソシアネート；ジオール鎖伸長剤；ポリグリコール；および、ポリウレタンベースの樹脂の骨格に、側鎖として、またはその両方に組み込まれるイオン性荷電修飾剤を含む成分の反応生成物である。実施形態では、イオン性荷電修飾剤は、アニオン性修飾剤とカチオン性修飾剤との組み合わせである。実施形態では、イオン性荷電修飾剤が双性イオン性であることが含まれる。本明細書における医療用物品は、固有の抗菌特性および／または防汚特性を有するか、または抗菌、防汚、および／または放射線不透過性を含む望ましい材料特性を提供するためにイオン性活性剤を容易に結合させることができる。

自己潤滑性医療用物品

Medizinisches material und verfahren zu seiner herstellung

Polyurethane based medical articles

Medical articles formed from a polyurethane-based resin including an ionically-charged modifier provide enhanced properties. The polyurethane-based resin is a reaction product of ingredients comprising: a diisocyanate; a diol chain extender; a polyglycol; and an ionically-charged modifier incorporated into a backbone, as a side chain, or both of the polyurethane-based resin. Embodiments include the ionically-charged modifier is a combination of anionic and cationic modifiers. Embodiments include the ionically-charged modifier is zwitterionic. Medical articles herein either have inherent antimicrobial and/or anti-fouling characteristics or can easily bond ionic active agents to provide desirable material properties, including antimicrobial, anti-fouling, and/or radiopacity.

自润滑医疗制品

由包括改性低聚物的基于聚氨酯的树脂形成的医疗制品提供了增强的性能。引入到由二异氰酸酯、聚二醇和二醇扩链剂形成的基于聚氨酯的树脂的主链中、作为侧链或者二者的改性低聚物具有至少一个，优选两个醇部分(C‑OH)和官能化部分。示例性改性低聚物是：引入所述主链中的含二醇的全氟聚醚，作为侧链引入的单官能化的聚硅氧烷(例如单二醇封端的聚二甲基硅氧烷)及其组合。此处的医疗制品是自润滑和/或防污性的。

Polimeri compatibili col sangue e dispositivi per uso medico prodotti da detti polimeri.