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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 21770. Отображено 100.
09-02-2012 дата публикации

Medical device and methods of monitoring a patient with renal dysfunction

Номер: US20120035432A1
Автор: Imad Libbus, Niranjan Chakravarthy, Rodolphe Katra
Принадлежит: Individual

Embodiments relate to a method of monitoring physiological parameters of a patient with renal dysfunction. The method includes electrically connecting one or more medical device electrodes with a measurement site of a patient, generating one or more first stimulation signals sufficient to provide input physiological parameters specific to the patient, measuring one or more first bioimpedance values from the generated signals, analyzing at least one of the input physiological parameters within the one or more first bioimpedance values and generating a personalized dialysis program. The systems and methods can further provide essentially real-time data of patient undergoing treatment and control of treatment to a patient.

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Номер записи: 1
16-02-2012 дата публикации

Devices, systems and methods for reducing the concentration of a chemical entity in fluids

Номер: US20120040429A1
Автор: Alan J. Russell, Heung-Il Oh, Joel L. Kaar, William J. Federspiel
Принадлежит: Individual

A method of improving the blood compatibility of a blood-contacting surface includes immobilizing carbonic anhydrase on the surface, wherein the surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the surface based on monolayer surface coverage of carbonic anhydrase.

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Номер записи: 2
26-04-2012 дата публикации

Dialysis device

Номер: US20120097587A1
Автор: Michael Herrenbauer, Robert Pohlmeier
Принадлежит: Individual

The invention relates to a dialysis device ( 1 ) having a dialysate circuit comprising a first dialyzer ( 3 ) and a second dialyzer ( 5 ) wherein the first dialyzer ( 3 ) is connectable to a blood circulation of a patient via a blood feed line ( 11 ) and a recirculation ( 13 ), an effluent for a retentate flow (Q effluent ) from the dialysate circuit to the second dialyzer ( 5 ) is provided and a permetate stream (Q out ) of the second dialyzer ( 5 ) in the dialysate circuit is passed to the first dialyzer ( 3 ), the second dialyzer ( 5 ) comprising a filter membrane having a cut-off value of at least 500 Da and the first dialyzer ( 3 ) comprising a filter membrane having a cut-off value exceeding that of the second dialyzer ( 5 ).

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Номер записи: 3
03-05-2012 дата публикации

Cassette system integrated apparatus

Номер: US20120106289A1
Автор: Brian Tracey, James D. Dale, Jason A. Demers, Kevin L. Grant, Michael J. Wilt
Принадлежит: Deka Products LP

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

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Номер записи: 4
14-06-2012 дата публикации

Acoustic access disconnection systems and methods

Номер: US20120150091A1
Автор: Robert W. Childers, Rodolfo G. Roger, Thomas D. Kelly
Принадлежит: Baxter Healthcare SA, Baxter International Inc

An access disconnection system includes a blood treatment machine including a housing, an access site detection housing separate from the blood treatment machine housing, a transmitter positioned in the access site housing and configured to transmit an ultrasound wave into a blood stream of a patient, a receiver positioned in the access site housing and configured to receive a reflection of the ultrasound wave from the blood stream of the patient; and electronic circuitry in communication with the transmitter and the receiver. The electronic circuitry is supported by the access site detection housing, and the transmitter is configured to send a wireless disconnection output to the blood treatment machine. The disconnection output is indicative of a change in the reflected ultrasound wave received by the receiver sufficient to expect that an access disconnection of one of the arterial line and the venous line has occurred.

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Номер записи: 5
05-07-2012 дата публикации

Medical Device Heaters and Methods

Номер: US20120168426A1
Автор: Frank Hedmann, Sven Sebesta, Ulrich Wernicke
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

A medical device having a heater with at least one heating element which has mains voltage applied to it by a heating control unit. The heating control unit includes a monitoring arrangement and a switching arrangement. The monitoring arrangement can recognize the zero crossings of the mains voltage, and the switching arrangement can switch the at least one heating element on or off in the zero crossing. The heating control unit controls the power of the heating by switching on and off of one or more half cycles of the mains AC voltage.

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Номер записи: 6
05-07-2012 дата публикации

Device and method for detecting blood or blood constituents in the liquid system of a device for extracorporeal blood treatment

Номер: US20120170020A1
Автор: Itka Bado, Peter Scheunert
Принадлежит: Individual

The present invention relates to a device and a method for detecting blood or blood constituents in the liquid system of a device for extracorporeal blood treatment, comprising a dialysis device or filter divided by a semipermeable membrane into a first chamber and a second chamber, wherein the first chamber is part of the extracorporeal blood circulation system and the second chamber part of the liquid system of the extracorporeal blood treatment device. The device according to the present invention for detecting blood or blood constituents in the liquid system of an extracorporeal blood treatment device is designed as a unit for differentiating between the entry of blood into the liquid system due to a defect of the dialysis device or filter, for example a rupture of the semipermeable membrane of the dialysis device or filter, or the entry of hemoglobin into the liquid system due to hemolysis, wherein a differentiation is made between a defect of the dialysis device or filter or hemolysis based on the change in intensity of at least the blue fraction of the light exiting from the liquid.

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Номер записи: 7
26-07-2012 дата публикации

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Номер: US20120189711A1
Автор: David G. Greenberg, Juan N. Walterspiel, Scott Puritz, Tatiana Koutchma
Принадлежит: Somerset Group Enterprises Inc

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

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Номер записи: 8
02-08-2012 дата публикации

Method and apparatus for machine error detection by combining multiple sensor inputs

Номер: US20120194335A1
Автор: James M. Brugger, Jeffrey H. Burbank
Принадлежит: Nxstage Medical Inc

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.

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Номер записи: 9
09-08-2012 дата публикации

Medical appliance

Номер: US20120200214A1
Автор: Jens foerger, Stefan Oesterreich
Принадлежит: Individual

This invention relates to a medical appliance, in particular an apparatus for the extracorporeal blood treatment, with a housing including a door and with a handle mechanism arranged at the door, by means of which the door can be locked with the housing via a locking mechanism, wherein a part of the locking mechanism is formed at the handle mechanism in its part protruding into the housing and wherein a form-fit unit is provided which includes at least one form-fit means and at least one form-fit means counterpart, wherein on locking and/or closing the door the at least one form-fit means at least partly engages in the at least one form-fit means counterpart.

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Номер записи: 10
09-08-2012 дата публикации

Methods and Apparatus for Inserting Multi-Lumen Split-Tip Catheters Into a Blood Vessel

Номер: US20120203206A1
Автор: Eric Tobin, Paramjith Anand, Shekhar Nimkar, Stephen E. Albrecht
Принадлежит: Bard Access Systems Inc

Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.

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Номер записи: 11
16-08-2012 дата публикации

Two-stage system and method for oxygenating and removing carbon dioxide from a physiological fluid

Номер: US20120209399A1
Автор: Anna Galea, Gordon B. Hirschman, Nicholas Vitale, Thieu Q. Truong
Принадлежит: Individual

A two-stage system for oxygenating and removing carbon dioxide from a physiological fluid, including: a primary exchange module configured to receive a gas having oxygen therein and a carrier fluid having carbon dioxide therein. The primary exchange module is configured to transfer oxygen from the gas to the carrier fluid and transfer carbon dioxide from the carrier fluid to the gas to create an oxygen loaded carrier fluid and a carbon dioxide load gas. A secondary exchange module is configured to receive the oxygen loaded carrier fluid and a physiological fluid having the carbon dioxide therein. The secondary exchange module is configured to transfer the oxygen from the oxygen loaded carrier fluid to the physiological fluid and transfer carbon dioxide from the physiological fluid to the carrier fluid to create an oxygen loaded physiological fluid.

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Номер записи: 12
30-08-2012 дата публикации

Dialysis cassettes and related systems and methods

Номер: US20120220937A1
Автор: Frank Hedmann, Stephan Klatte
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

A method that includes conveying overheated dialysate through a cassette in a manner to reduce the temperature of the overheated dialysate, and a dialysis system including a control unit configured to cause overheated dialysate to be conveyed through a cassette in a manner to reduce the temperature of the overheated dialysate.

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Номер записи: 13
06-09-2012 дата публикации

Mecs dialyzer method

Номер: US20120223015A1
Автор: Brian Kevin Paul, David M. Browning, Goran Nadezda Jovanovic, James R. Curtis, Sundar Atre
Принадлежит: Individual

The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.

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Номер записи: 14
13-09-2012 дата публикации

Non-invasive radio frequency liquid level and volume detection system using phase shift

Номер: US20120227484A1
Автор: Gert NAJDENI, Joel TITUS, Matthew Muller, Ye Chen, Yuanpang Samuel Ding
Принадлежит: Baxter Healthcare SA, Baxter International Inc

A medical fluid system includes a medical fluid pump; a container holding a fluid to be pumped by the medical fluid pump, the fluid at a first time having a first conductivity, the fluid at a second time having a second conductivity; and a radio frequency level sensor positioned in operable relation with the container, the radio frequency operation of the level sensor configured so as to be (i) indicative of a level of the fluid in the container and (ii) at least substantially independent of whether the fluid has the first conductivity or the second conductivity. The medical fluid system can determine the level of medical fluid by measuring the resistance, impedance or phase shift seen by the sensor.

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Номер записи: 15
13-09-2012 дата публикации

Kidney substitution treatment machine

Номер: US20120228226A1
Автор: Alex Castellarnau, Jörn Ahrens, Stefan Moll
Принадлежит: B Braun Avitum AG

The invention relates to a method for normalizing, storing and/or displaying curves describing the adequacy of a kidney substitution treatment wherein the treatment is provided by a machine which has an extracorporeal blood system ( 31, 32 ) pumping the patient's blood at a preset flow rate through the blood chamber ( 30 ) of a dialyzer which is divided by a semi-permeable membrane into the blood chamber ( 30 ) and a dialyzing fluid chamber ( 29 ), and wherein the dialyzing fluid flows at a preset flow rate through the dialyzing fluid system ( 20, 36 ) of the machine and collects the waste products from the patient, and wherein a device ( 37 ) capable of continuously measuring any treatment related waste product is provided to deliver together with the data provided by the treatment machine an adequacy parameter, wherein curves describing the adequacy of the treatment are normalized to make them comparable, and/or stored in an adequate media and/or displayed on the user interface of the machine and wherein means are available to calculate parameters quantifying the adequacy differences between treatments.

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Номер записи: 16
20-09-2012 дата публикации

Filter blood fluid channel methods, devices, and systems

Номер: US20120234746A1
Автор: Edward F. Leonard, John Howard, Thomas Qin
Принадлежит: Columbia University of New York

A risk of thrombogenesis is minimized in a tubular fiber membrane filter by flowing blood or other fluid through a header manifold that ensures a minimum shear rate on the wetted surfaces without flow reversal, stagnation volumes, or a shear rate that is too high. In an embodiment, fluid is conveyed into a header space and into a manifold face at a perimeter of the header space. The header space has a progressively decreasing clearance that is minimal to provide for substantial shear rate and decreasing toward a minimum clearance in a region that is remote from the perimeter and vented by openings to the microtubular membrane fibers. Other features and embodiments are described.

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Номер записи: 17
04-10-2012 дата публикации

Device for collecting samples

Номер: US20120253268A2
Автор: Alain Veneroni, Daniel Daetwyler, Dominik Uehlinger, Mihai Diga
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to a device ( 20 ) for collecting dialysate samples ( 42 ). The device ( 20 ) comprises an inlet ( 22 ) for receiving a flow of dialysate, a plurality of outlets ( 24 ) for providing a flow of saturated dialysate and means ( 26 ) for sequential selection of one of the outlets ( 24 ). The sequential selection means ( 26 ) are activated only by the flow of dialysate received from the inlet ( 22 ). The present invention further relates to a system for peritoneal dialysis comprising such device ( 20 ).

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Номер записи: 18
25-10-2012 дата публикации

Medical fluid pumping systems and related devices and methods

Номер: US20120271226A1
Автор: Deloy Lindley, Gurpreet Singh, Ignacio Serrato, Kulwinder S. Plahey, Michael David Young, Sean Farrell, Tri Ly, Venugopal Raghavendra Ghatikar
Принадлежит: Fresenius Medical Care Holdings Inc

This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a medical fluid pumping system includes a medical fluid pumping machine including a piston head that can be linearly displaced and a medical fluid cassette that can be secured to the medical fluid pumping machine. The medical fluid cassette includes a fastening member attached to a region of a flexible membrane overlying a fluid pump chamber, and the piston head is configured to be mechanically connected to the fastening member of the cassette.

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Номер записи: 19
25-10-2012 дата публикации

Medical fluid autoconnection and autoidentification method

Номер: US20120271273A1
Автор: Andrey Kopychev, Douglas Reitz, John F. Steck, Patrick Lee, Robert W. Childers, Rodolfo Roger
Принадлежит: Baxter Healthcare SA, Baxter International Inc

A medical fluid autoconnection method includes: enabling acceptance a pierceable connector that is capable of fluidly communicating with a source of medical fluid into a moveable holder; temporarily fixing a spike to a medical fluid pumping machine; automatically detecting whether the pierceable connector has been placed into the moveable holder; if the pierceable connector is sensed as being placed in the moveable holder, moving the holder so that the spike pierces the pierceable connector; and enabling medical fluid to be pumped from the source through the connected spiked and connector.

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Номер записи: 20
01-11-2012 дата публикации

Multimodal dialysis system

Номер: US20120273354A1
Автор: Bryant J. Pudil, Soykan Orhan, Thomas E. Meyer
Принадлежит: MEDTRONIC INC

A dialysis device for operation in multiple modes and for maintaining a known gradient of potassium ion or other electrolyte between the blood of a patient and a dialysate fluid is described. The dialysis device is capable of being used for hemodialysis or peritoneal dialysis, and the dialysis device is capable of operation with a dialysate purification unit outside of a clinical setting or with a supply of water that can be supplied in a clinical setting. The dialysis device has a composition sensor containing a potassium-sensitive electrode for measuring a potassium ion concentration in one or more of the patient's blood and the dialysate fluid and an infusate pump operated to adjust a potassium ion concentration in the dialysate fluid based at least in part on data from the composition sensor.

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Номер записи: 21
15-11-2012 дата публикации

Multichamber container for preparing medicinal solutions

Номер: US20120288572A1
Автор: Franz Kugelmann, Joern Hoermann
Принадлежит: Individual

The subject matter of the present invention is a multichamber container and a method for preparing medical fluids composed of concentrates which make a contribution toward the electrical conductivity of the solution and are additionally prepared from concentrates which do not make a contribution toward the electrical conductivity of the solution. The inventive multichamber container is characterized in that it is constructed by dividing the solution components into multiple chambers, so that following the dissolving due to breaking open of the first chamber border of a solution component, which makes a contribution toward the electrical conductivity of the medicinal solution, another chamber border of another solution component which does not make any contribution toward the electrical conductivity of the solution is broken open.

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Номер записи: 22
20-12-2012 дата публикации

Method for regulating the supply of substituting during extracorporeal blood treatment and extracorporeal blood treatment device comprising a unit for regulating the supply of substituate

Номер: US20120318739A1
Автор: Alfred Gagel, Pascal Kopperschmidt
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

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Номер записи: 23
27-12-2012 дата публикации

Filtration system for preparation of fluids for medical applications

Номер: US20120325696A1
Автор: Brian C. Green, Christopher S. Mcdowell, Dennis M. Treu, Goetz Friederichs, Jeffrey H. Burbank
Принадлежит: Nxstage Medical Inc

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment which provides multiple benefits and liabilities to overcome, as discussed herein. Mechanisms for preparing pure water for infusion or medicaments are described such as elimination of chlorine and colloidal aluminum. Also various control mechanisms to help avoid contamination are describe.

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Номер записи: 24
03-01-2013 дата публикации

System for carrying out a blood treatment

Номер: US20130001165A1
Автор: Alfred Krause, Michael Herrenbauer, Patricia Goempel-Klein, Robert Pohlmeier, Wolfgang Wehmeyer
Принадлежит: Individual

The present invention relates to a system for the carrying out of a blood treatment, in particular a dialysis treatment, wherein the system has at least one blood treatment device, in particular a dialyzer, and at least one tank from which treatment fluid, in particular dialysis fluid, is removed during the carrying out of the blood treatment and/or into which consumed treatment fluid, in particular consumed dialysis fluid, is filled during the carrying out of the blood treatment, wherein the tank is an element of at least one mobile apparatus which can be connected to the blood treatment device such that at least one fluid connection can be established between the tank and the blood treatment device.

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Номер записи: 25
10-01-2013 дата публикации

Molecularly imprinted polymers for eliminating metabolites

Номер: US20130011364A1
Автор: Ingo Bichlmaier, Thomas Fichert
Принадлежит: Individual

The present invention relates to polymers imprinted by retention solutes, use of same as well as compositions containing same.

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Номер записи: 26
17-01-2013 дата публикации

Dialysis Systems and Methods

Номер: US20130018301A1
Автор: Colin Weaver, Martin Joseph Crnkovich
Принадлежит: Fresenius Medical Care Holdings Inc

This invention relates to dialysis systems and methods. In some implementations, a method includes applying vacuum pressure to a device of a dialysis system, and then determining, based on a detected fluid level or measured pressure, whether the device is functioning properly.

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Номер записи: 27
24-01-2013 дата публикации

Cassette system integrated apparatus

Номер: US20130022483A1
Автор: Brian Tracey, James D. Dale, Jason A. Demers, Kevin L. Grant, Michael J. Wilt
Принадлежит: Deka Products LP

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

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Номер записи: 28
31-01-2013 дата публикации

Medical functional device, treatment apparatus and method

Номер: US20130025692A1
Автор: Alexander Heide, Arne PETERS, Christoph WIKTOR, Juergen Klewinghaus, Robin Partenfelder
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

A medical functional device includes at least one first fluid system for receiving at least one medical fluid, at least one first conveying device for conveying the medical fluid, at least one second fluid system for receiving at least one operating fluid, and at least one second conveying device for operating the at least first conveying device, in which the first conveying device is arranged such as to be actuated by means of the operating fluid. A treatment apparatus and a method are also described.

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Номер записи: 29
31-01-2013 дата публикации

Method as well as apparatuses for detecting a permeability or patency in a tube which is inserted in a tube pump

Номер: US20130030345A1
Автор: Joachim Manke, Soeren Gronau
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to a method for detecting a permeability or patency of a section of an extracorporeal tube which is inserted in a tube pump, a detection device for executing a method according to the present invention, a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission with it or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

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Номер записи: 30
31-01-2013 дата публикации

Sodium management for dialysis systems

Номер: US20130030356A1
Автор: Rongsheng Lin, Ying-Cheng Lo, Yuanpang Samuel Ding
Принадлежит: Baxter Healthcare SA, Baxter International Inc

Systems and methods for providing dialysis therapies are provided. In a general embodiment, the present disclosure provides an apparatus for dialysis treatment comprising first and second fluid flow pathways in a parallel arrangement. The first fluid flow pathway contains a first cation exchange resin, wherein greater than 90% of exchange sites of the first cation exchange resin are populated with hydrogen ions. The second fluid flow pathway contains a second cation exchange resin, wherein greater than 90% of exchange sites of the second cation exchange resin are populated with sodium ions. The apparatus can be used to maintain a constant and safe level of sodium in a constantly regenerated dialysis fluid over an extended period of time.

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Номер записи: 31
14-02-2013 дата публикации

Blood treatment systems and methods

Номер: US20130037485A1
Автор: Brian K. YEE, Catharine N. Flynn, Dirk A. Van Der Merwe, Jonathan P. Rosse, Kevin L. Grant, Michael J. Wilt, Todd A. Ballantyne
Принадлежит: Deka Products LP

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

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Номер записи: 32
28-03-2013 дата публикации

Pumping cassette

Номер: US20130074959A1
Автор: Brian D. Tracey, James D. Dale, Jason A. Demers, Kevin L. Grant, Michael J. Wilt
Принадлежит: Deka Products LP

A pump cassette is disclosed. The pump cassette includes a housing having at least, one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

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Номер записи: 33
28-03-2013 дата публикации

CASSETTE WITH A SENSOR FOR DETERMINING THE DIFFERENCE BETWEEN A FIRST AND A SECOND FLUID STREAM

Номер: US20130075314A1
Автор: Heide Alexander, Nikolic Dejan
Принадлежит:

The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement. 1. Cassette with a first and a second fluid stream in a dialysis system , wherein the cassette has a sensor as a device for determining a difference between the first and the second fluid stream and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream.2. Cassette according to claim 1 , wherein the first and the second fluid streams are dialysate streams or blood streams.3. Cassette according to claim 1 , wherein:the first and the second channel are disposed substantially parallel to each other; andthe sensor is configured to expose the first and the second channel to a magnetic field for determining the difference between the first and the second fluid streams, wherein the magnetic field is aligned substantially perpendicular to the first and to the second channel.4. Cassette according to claim 3 , wherein:due to the magnetic field a separation of positive and negative charge carriers occurs in the first fluid stream of the first channel and in the second fluid stream of the second ...

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Номер записи: 34
28-03-2013 дата публикации

CARDIOVASCULAR DEVICE

Номер: US20130079583A1
Автор: Parravicini Roberto
Принадлежит:

A cardiovascular device (), adapted to be fitted into a cardiac ventricular cavity () having a volume with blood flowing therethrough, which is bounded by walls () and has a larger longitudinal dimension (D) and a smaller transverse dimension (D), characterized in that it comprises diaphragm means () that can be disposed in said ventricular cavity () substantially transverse to said larger longitudinal dimension (D), in such an arrangement as to reduce said volume, said diaphragm means () having a peripheral edge () which can be sealingly engaged with said walls () and being adapted to be alternately driven between an active blood pushing displacement and an inactive return displacement. 1. A cardiovascular device , to be fitted in a ventricular cardiac cavity having a volume wherein blood flows , which is bounded by walls and has a greater longitudinal dimension and a lower transverse dimension , said device comprising diaphragm means that can be fitted inside said ventricular cardiac cavity substantially transverse to said greater longitudinal dimension , so as to reduce said volume , said diaphragm means having a peripheral edge which can be sealingly engaged with said walls and being alternatively driven between an active shifting of pushing blood and an inactive back shifting.2. A device according to claim 1 , wherein each of said active shifting and inactive shifting are substantially synchronized respectively with a systole and a diastole of the heart.3. A device according to claim 1 , wherein said diaphragm means are movably actuated by actuating means.4. A device according to claim 1 , wherein said diaphragm means are movably driven by pushes of said walls during said systole and diastole.5. A device according to claim 3 , wherein said diaphragm means comprise:A planar element equipped with said peripheral edge, movable alternatively between a pushing position and a backward position;A support frame of said planar element that is movable between said ...

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Номер записи: 35
04-04-2013 дата публикации

METHOD FOR CONTROLLING OF A FILTRATION RATE, CONTROLLER, AND DEVICES

Номер: US20130081998A1
Автор: Chamney Paul, MOISSL Ulrich, Wabel Peter, Wieskotten Sebastian
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to a method for controlling a filtration rate during treatment of a body fluid, e.g., during hemofiltration or dialysis, comprising the steps of defining a target relation, or a development during dialysis thereof, between one or more calculated or measured value(s) reflecting the mass, concentration, or the volume of a substance comprised by a patient's tissue or bodily fluid, and one or more calculated or measured value(s) reflecting a patient's distribution space or an approximation thereof; during dialysis repeatedly calculating or measuring value(s) reflecting the mass, concentration or the volume of the substance and/or reflecting the distribution space or an approximation thereof, and determining the relation therebetween at least once; and controlling the filtration rate of the body fluid treatment device such that the determined relation is or approaches the target relation. It also relates to systems for conducting the method, and related computer-readable storage media. 122-. (canceled)23. A method for controlling of a filtration rate during treatment of a bodily fluid of a patient by utilization of a bodily fluid treatment device , comprising the steps of:defining a target relation, or a development thereof during fluid treatment, between one or more calculated or measured value(s) reflecting the mass or the concentration or the volume of a substance comprised by a tissue or a bodily fluid of the patient, and one or more calculated or measured value(s) reflecting a distribution space of the patient or an approximation thereof;during treatment of the bodily fluid repeatedly calculating or measuring of value(s) reflecting the mass or the concentration or the volume of the substance and/or reflecting the distribution space or an approximation thereof, and determining the relation there between at least once; andcontrolling of the filtration rate of the fluid treatment device such that the determined relation is or approaches ...

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Номер записи: 36
04-04-2013 дата публикации

SYSTEM FOR INTRODUCING A PUMP

Номер: US20130085318A1
Автор: Toellner Thomas
Принадлежит: ECP ENTWICKLUNGSGESELLSCHAFT MBH

The invention resides in the field of introducing fluid pumps into a lumen and relates to a system for introducing a pump into a lumen which comprises a first sheath and a pump to be introduced into the first sheath, or a system which has a pump with a distal pump unit and a shaft catheter which emerges proximally to the pump unit. 123-. (canceled)24. A system for introducing a pump into a lumen , comprising a first sheath and a pump to be introduced into the first sheath , the first sheath having a first sheath lumen which extends from a distal end to a proximal end for guiding the pump , wherein a second sheath with a second sheath lumen which extends from a distal end to a proximal end , is present , and in which the pump is retained in a guidable manner , the second sheath being able to be coupled to the first sheath for transferring the pump into the first sheath lumen.25. The system according to claim 24 , wherein the first sheath lumen has claim 24 , at least in regions claim 24 , a smaller claim 24 , equally-sized or a larger inner cross-sectional area than the second sheath lumen.26. The system according to claim 25 , wherein the first sheath lumen has a smaller claim 25 , equally-sized or a larger inner diameter than the second sheath lumen.27. The system according to claim 25 , wherein the first sheath has claim 25 , at the proximal end thereof claim 25 , a first sheath valve claim 25 , the first sheath lumen preferably widening towards the proximal end thereof and being configured such that the distal end of the second sheath can be introduced into the sheath valve.28. The system according to claim 27 , wherein the second sheath is a tear-off sheath which can be torn off.29. The system according to claim 28 , wherein the first and/or second sheath has a plastic material.30. The system according to claim 29 , wherein a guide wire is included claim 29 , the cross-sectional area of which is chosen such that the guide wire can be guided through the first ...

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Номер записи: 37
04-04-2013 дата публикации

EXPANDABLE BLOOD PUMPS AND METHODS OF THEIR DEPLOYMENT AND USE

Номер: US20130085319A1
Автор: Evans Don W. E., Maniak Jeremy John
Принадлежит:

A pump for inducing motion of a fluid, the pump including a cannula adjustable between an operable configuration having a first diameter and a deployment configuration having a substantially smaller second diameter. An impeller is rotatable within the cannula about an axis. The impeller includes an at least semi-rigid support for a flexible web, and is positionable with respect to the cannula the operable configuration and the deployment configuration, the operable configuration extending the web to a first radial distance from the axis and the deployment configuration collapsing the web to a second substantially smaller radial distance from the axis. 1. A pump for inducing flow within a vascular system , the pump comprising:an cannula having at least one section adjustable between an operable configuration and a deployment configuration having a substantially smaller diameter than the operable configuration; andan impeller positioned within the adjustable section of the cannula and rotatable therein about an impeller axis, the impeller comprising a support for a flexible web, the support being positionable with respect to the cannula between the operable configuration and the deployment configuration, the operable configuration extending at least a portion of the web to a first radial distance from the impeller axis and the deployment configuration collapsing the portion of the web to a second substantially smaller radial distance from the impeller axis.2. The pump of claim 1 , wherein the cannula comprises a spiral support member claim 1 , the spiral support member spiraling about the impeller axis.3. The pump of claim 2 , wherein the spiral support member is adjustable from the operable configuration to the deployment configuration by twisting.4. The pump of claim 2 , wherein the spiral support member is adjustable from the operable configuration to the deployment configuration by axial positioning proximal and distal ends of the cannula with respect to one ...

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Номер записи: 38
04-04-2013 дата публикации

Tip Configurations for Multi-Lumen Catheter

Номер: US20130085436A1
Автор: Barrett Joseph, Hamatake Bret, Herzog Dallen Glen, Orome Amir, Stats Jason R.
Принадлежит: C. R. BARD, INC.

Multi-lumen catheters with improved tip configurations, including a triple-lumen catheter which may be useful for apheresis. In one variation, the catheter has three lumens with distal openings angularly spaced apart and staggered axially with respect to one another. In another variation, the catheter has two lumens exiting distally and one centrally positioned lumen exiting proximally. A third variation is a catheter with a single distal opening and two proximal openings. The staggered lumen openings along the axial length of the catheter may decrease recirculation while maximizing flow rates. 1. A multi-lumen catheter , comprising:a first interior wall separating a first lumen from a second lumen;a second interior wall separating the first lumen from a third lumen;a third interior wall separating the second lumen from the third lumen;a first distal opening in fluid communication with the first lumen;a second distal opening in fluid communication with the second lumen; anda third distal opening in fluid communication with the third lumen, the third distal opening positioned alongside the second distal opening at a distal end of the catheter, the first distal opening positioned proximal of the second and third distal openings.2. The multi-lumen catheter according to claim 1 , wherein the second and third lumens increase in cross-sectional area from the first distal opening to the distal end of the catheter.3. The multi-lumen catheter according to claim 2 , wherein a first overall cross-sectional area of the catheter proximal of the first distal opening is less than a second overall cross-sectional area distal of the first distal opening.4. The multi-lumen catheter according to claim 1 , wherein the second interior wall and the first interior wall form an angle of approximately 120 degrees.5. The multi-lumen catheter according to claim 1 , wherein a first overall cross-sectional area of the catheter proximal of the first distal opening is greater than a second ...

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Номер записи: 39
18-04-2013 дата публикации

PUMP AND METHOD FOR MIXED FLOW BLOOD PUMPING

Номер: US20130096364A1
Автор: Andriola Peter, Briana Stephen G., Eldridge David Gary, Hodges William V., le Blanc Pieter W.C.J., Petersen Ethan, Reichenbach Steven H., Woo Yi-Ren
Принадлежит:

A blood pump includes a hub having an axis of rotation and a generally cylindrical shape. The hub has an upstream end region, a central region, and a downstream end region, and the hub includes a magnetic material. Blades that are disposed on the downstream end region of the hub extend downstream of the hub. 1. A blood pump comprising:a hub having an axis of rotation and a generally cylindrical shape, the hub having an upstream end region, a central region, and a downstream end region, the hub including a magnetic material; and an upstream portion that is located proximate the hub and is configured to add energy to fluid having forward flow along the axis of the hub, and', 'a downstream portion that is configured to add energy to the fluid having forward flow in a direction radially outward from the hub., 'blades located at the downstream end region of the hub, the blades extending downstream of the hub, each blade including'}2. The blood pump of claim 1 , wherein the downstream portions of the blades extend radially outward from the hub.3. The blood pump of claim 1 , wherein the blood pump includes a housing claim 1 , and the hub is suspended within the housing by fore and aft bearings.4. The blood pump of claim 1 , wherein the central region and the upstream end region are devoid of blades.5. The blood pump of claim 1 , further comprising:a housing defining an inlet, an outlet, and a flow path from the inlet to the outlet; anda motor stator disposed within the housing.6. The blood pump of claim 5 , further comprising stator blades disposed within the flow path proximate the upstream end region of the hub claim 5 , the stator blades being coupled to an upstream bearing component for supporting the upstream end region of the hub.7. The blood pump of claim 5 , further comprising a downstream bearing component for supporting the downstream end region of the hub claim 5 , the downstream bearing component being located proximate the downstream end region of the hub and ...

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Номер записи: 40
25-04-2013 дата публикации

Medium, devices and methods

Номер: US20130098834A1
Автор: Jonas Axelsson
Принадлежит: JJK MEDICAL Ltd

A separation medium is provided, comprising at least one megalin polypeptide and/or at least one cubilin polypeptide immobilized on a support. Also provided are devices comprising the separation medium, as well as methods and uses employing the separation medium for extracorporeal removal of low molecular weight proteins, or fragments or derivatives thereof, from complex biological fluids.

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Номер записи: 41
25-04-2013 дата публикации

Apparatus and Kit For Encapsulating At Least One Compound For Therapeutic and/or Diagnostic Use in Erythrocytes

Номер: US20130101463A1
Автор: Mambrini Giovanni, Serafini Sonja
Принадлежит: ERYDEL S.P.A.

A portable and highly automated apparatus and method for introducing at least one compound within erythrocytes; the apparatus comprises a reusable part provided with mechanical elements such as pumps and valves and electronic units such as a control unit; the apparatus also comprises a disposable part, which is adapted to come into contact with the sample containing the erythrocytes and is provided with a system of tubes made of deformable material, a plurality of reservoirs and one or more filters; the apparatus allows a further concentration of the erythrocytes after they have been treated; the apparatus allows to introduce the compound in the erythrocytes in a virtually totally automated manner. 112910314567689101161213. An apparatus for introducing at least one compound within erythrocytes; the apparatus () comprises a system () of connection channels , which includes a first and a second channel ( , ); an introducing unit () for inserting a sample containing the erythrocytes within the apparatus (); a separating unit () for separating the different components of the sample from one another; a combining unit () , which comprises a first reservoir () and in the area of which the erythrocytes and the compound are combined together so as to obtain treated erythrocytes; an inlet () for inserting the compound in the first reservoir (); a feeding unit () , for feeding a first solution through the first channel () and feeding a second solution through the second channel (); a concentrating unit () for concentrating the content of the first reservoir (); and a collecting unit () , which comprises a second reservoir () for collecting treated erythrocytes;{'b': 2', '3', '4', '5', '8', '11', '12, 'the system () of channels connecting the introducing unit (), the separating unit (), the combining unit (), the feeding unit (), the concentrating unit () and the collecting unit ();'}{'b': 1', '15', '49', '15', '3', '4', '5', '12, 'the apparatus () being characterised by ...

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Номер записи: 42
25-04-2013 дата публикации

Device for treating blood in an extracorporeal circulation

Номер: US20130101465A1
Автор: Daniele Galavotti
Принадлежит: Rand Srl

A device for oxygenating blood during extracorporeal circulation includes a box-like body having a first end and a second end opposite thereto and defining therebetween a treatment chamber with an inner surface. The device further includes, in the treatment chamber, at least one exchange unit having at least one flat diaphragm that is impervious to blood and has a major axis and a minor axis. The diaphragm has a winding of hollow microporous fibers. The device further includes an inlet port and an outlet port axially aligned with one another in an alignment direction. A compartment is provided for accumulation and delivery of blood to be treated, another compartment for collecting treated blood, the compartments being located downstream of the inlet port and upstream of the outlet port, between the exchange unit and the inner surface of the treatment chamber. The diaphragm is disposed with the major axis parallel to the alignment direction.

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Номер записи: 43
02-05-2013 дата публикации

DETECTION DEVICE AND METHOD

Номер: US20130105371A1
Автор: Frorip Aleksandr, Nacke Christoph
Принадлежит: B. Braun Avitum AG

Detection device for quantitative detection of predetermined molecules, in particular medium size protein molecules, in a sample liquid with a light source for emitting measurement radiation, a section for irradiating the sample liquid and a light detector for measuring the detection radiation exiting the section for irradiating the sample liquid, as well as an analysis stage located downstream of the light detector for analyzing the detector signal, wherein the light source is designed such that the measurement radiation has a spectral range exciting the intrinsic fluorescence of a molecule to be determined, and the light detector is designed such that at least one spectral range of the detection radiation is measured, in which the molecule emits intrinsic fluorescence radiation. 111-. (canceled)12. A detection device for quantitative detection of predetermined molecules , in particular medium-sized protein molecules , in a sample liquid with a light source for emitting measurement radiation , a section for irradiating the sample liquid and a light detector for measuring the detection radiation exiting the section for irradiating the sample liquid , as well as an analysis stage located downstream of the light detector for analyzing the detector signal , wherein the light source is designed such that the measurement radiation has a spectral range exciting the intrinsic fluorescence of a molecule to be determined , and the light detector is designed such that at least one spectral range of the detection radiation is measured , in which the molecule emits intrinsic fluorescence radiation.13. The detection device according to claim 12 , wherein the light source is a UV-radiation source emitting detection radiation exciting the intrinsic fluorescence of tryptophan claim 12 , in particular at 280 nm claim 12 , and the light detector is a photodiode or a photomultiplier claim 12 , which is sensitive in a spectral range claim 12 , in which intrinsic fluorescence radiation ...

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Номер записи: 44
02-05-2013 дата публикации

VALVE ARRANGEMENT FOR USE IN AN EXTRACORPOREAL BLOOD CIRCUIT AND METHOD

Номер: US20130110028A1
Автор: Bachmann Angelika, HERRENBAUER Michael, Wehmeyer Wolfgang
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to a valve arrangement for use in an extracorporeal blood circuit having at least one arterial blood line and at least one venous blood line, the valve arrangement having at least one first valve arranged in the arterial blood line, a second valve arranged in the venous blood line, a fourth valve arranged in a first arteriovenous connection line between the arterial blood line of the circuit and the venous blood line of the circuit, and a fifth valve arranged in a second arteriovenous connection line between the arterial blood line and the venous blood line; and/or a third valve arranged for establishing a fluid connection in a blood line between the arterial blood line and the venous blood line of the circuit; and/or a sixth valve arranged between a blood treatment device and an air venting device of the circuit. 133-. (canceled)34. A system having a valve arrangement for use in an extracorporeal blood circuit comprising at least one arterial blood line and at least one venous blood line , wherein the valve arrangement comprises at least:a first valve which is arranged in the arterial blood line, a second valve which is arranged in the venous blood line, a fourth valve which is arranged in a first arteriovenous connection line between the arterial blood line of the extracorporeal blood circuit and the venous blood line of the extracorporeal blood circuit, and a fifth valve which is arranged in a second arteriovenous connection line between the arterial blood line and the venous blood line; and/ora third valve which is arranged for establishing a fluid connection in a blood line between the arterial blood line and the venous blood line of the extracorporeal blood circuit; and/ora sixth valve which is arranged between a blood treatment device and an air venting device of the extracorporeal blood circuit.35. The system according to claim 34 , comprising the first valve claim 34 , the second valve claim 34 , the third valve claim 34 , the ...

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Номер записи: 45
02-05-2013 дата публикации

Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same

Номер: US20130110137A1
Автор: Ali Hussain, Brian J Fill, Enrico Nicolo, Greg Johnson, Jeffrey W. Speakman, Linda Cahalan, Mark Gartner, Patrick Cahalan
Принадлежит: Ension Inc

A variety of polymeric synthetic hernia mesh prosthesis with surface treatment on at least one tissue-facing surface to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm 2 , and ii) a thrombin deactivation of at least 0.2 IU/cm 2 ; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment. The synthetic hernia mesh may be formed of monofilament or multifilament polypropylene or polyester, and may be formed as a multi-layer prosthesis with an outer layer formed of a polymeric synthetic hernia mesh with surface treatment to control tissue adhesion coupled to one or more polymeric synthetic hernia meshes without such surface treatments.

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Номер записи: 46
09-05-2013 дата публикации

VIBRATION-ASSISTED DIALYSIS METHOD

Номер: US20130112620A1
Автор: Mueller Bruce A.
Принадлежит: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Disclosed herein are an apparatus and method of increasing dialysis dose and waste removal with the introduction of mechanical energy, such as vibration, to a hemodiafiltration membrane The method generally includes providing a dialyzer that includes a vibration element in engaged vibratory communication with a hemodiafiltration membrane The method also includes enabling extracorporeal flow of pre-dialyzed blood and a dialysate through the dialyzer and respectively past opposing surfaces of a vibrating hemodiafiltration membrane to achieve a solute clearance from the pre-dialyzed blood that is at least about 10% greater than a solute clearance from the pre-dialyzed blood obtained in the absence of the engaged vibratory communication Various apparatus are also disclosed, each of which includes a vibration element in vibratory communication with the dialyzer. 1. A method of hemodiafiltration , the method comprising:(a) providing a dialyzer that includes a vibration element in engaged vibratory communication with a hemodiafiltration membrane; and,(b) enabling extracorporeal flow of pre-dialyzed blood and a dialysate through the dialyzer and respectively past opposing surfaces of the vibrating hemodiafiltration membrane to achieve a solute clearance from the pre-dialyzed blood that is at least about 10% greater than a solute clearance from the pre-dialyzed blood obtained in the absence of the engaged vibratory communication.2. The method of claim 1 , wherein the achieved clearance is at least about 15% greater than the solute clearance from the pre-dialyzed blood obtained in the absence of the engaged vibratory communication.3. The method of claim 1 , wherein the achieved clearance is about 10% to about 20% greater than the solute clearance from the pre-dialyzed blood obtained in the absence of the engaged vibratory communication.4. The method of claim 1 , wherein the achieved clearance is about 15% to about 20% greater than the solute clearance from the pre-dialyzed ...

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Номер записи: 47
09-05-2013 дата публикации

FLUID PUMPING SYSTEMS, DEVICES AND METHODS

Номер: US20130115105A1
Автор: Dale James D., Demers Jason A., Gray Larry B., Leonard Scott A., Perry N. Christopher, Tracey Brian D., Wilt Michael J.
Принадлежит: DEKA Products Limited Partnership

Embodiments of the present invention relate generally to certain types of reciprocating positive-displacement pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid. The pumps may be configured specifically to impart low shear forces and low turbulence on the fluid as the fluid is pumped from an inlet to an outlet. Such pumps may be particularly useful in pumping fluids that may be damaged by such shear forces (e.g., blood, and particularly heated blood, which is prone to hemolysis) or turbulence (e.g., surfectants or other fluids that may foam or otherwise be damaged or become unstable in the presence of turbulence). 198-. (canceled)99. An actuation system for a reciprocating membrane-based pump having a pumping chamber separated from an actuation chamber by a flexible membrane , a delivery stroke resulting from the application of positive pressure in the actuation chamber , and a fill stroke resulting from the application of negative pressure in the actuation chamber , the actuation system comprising:at least one valve fluidly connecting the actuation chamber with a reservoir arranged to supply positive pressure to the actuation chamber and fluidly connecting the actuation chamber with a reservoir arranged to supply negative pressure to the actuation chamber;a controller configured to signal the at least one valve to operate in a plurality of pulses during a delivery stroke or a fill stroke, each pulse comprising an opening period and a closing period of the valve; whereinthe controller is configured to command the at least one valve to pulse with an opening period during an initial phase of a delivery or fill stroke that is longer than an opening period during a later phase of the delivery or fill stroke.100. The actuation system of claim 99 , wherein the opening period during the ...

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Номер записи: 48
09-05-2013 дата публикации

DIALYSIS APPARATUS AND METHOD FOR CONTROLLING A DIALYSIS APPARATUS

Номер: US20130116650A1
Автор: Bene Bernard, Vantard Georges
Принадлежит: GAMBRO LUNDIA AB

Dialysis apparatus including a blood treatment unit having a dialysate chamber and a blood chamber separated by a semipermeable membrane, a dialysate circuit presenting a supply line and a discharge line connected to the blood treatment unit, a preparation device for preparing a dialysate containing a substance present in the blood too and a regulator regulating the concentration of the substance in the dialysate. A blood circuit to circulate extracorporeal blood through the blood chamber; a controller that determines a value representative of the concentration of the substance in the blood and are programmed for driving the regulator as a function of the determined value representative of the substance concentration in the blood such that the substance concentration in the dialysate tends towards the substance concentration in the blood. 118. to . (canceled)19. A dialysis apparatus comprising:a blood treatment unit comprising a dialysate chamber and a blood chamber separated by a semipermeable membrane;a dialysate circuit comprising a supply line and a discharge line connected to said blood treatment unit, respectively, upstream and downstream of said dialysate chamber;a preparation device configured to prepare a dialysate containing a substance which is also present in blood, the preparation device includes a regulator configured to regulate a concentration of the substance in dialysate, said preparation device being connected to said supply line;a blood circuit configured to circulate extracorporeal blood through said blood chamber;a controller configured to determine a value representative of the concentration of said substance in the blood and configured to drive the regulator as a function of the determined value representative of the substance concentration in the blood such that the substance concentration in the dialysate trends towards the substance concentration in the blood.20. The apparatus according to claim 19 , wherein said substance is a ionic ...

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Номер записи: 49
16-05-2013 дата публикации

Dialysis Systems and Related Methods

Номер: US20130118961A1
Автор: Beden Josef, Braun Juergen, Schneider Hans-Peter
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

A dialysis machine that includes a valve member having a deformable area configured to deform outwardly away when pressurized fluid is introduced into the valve member. The valve member is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the valve member, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough. 1. A dialysis system , comprising:a dialysis machine having a cassette compartment configured to receive a dialysis fluid cassette that comprises a fluid channel formed between a base and a flexible membrane that is attached to the base, the cassette compartment being configured such that the membrane of the dialysis fluid cassette is positioned adjacent a machine block of the dialysis machine when the dialysis fluid cassette is disposed in the cassette compartment of the dialysis machine;a valve member at least partially disposed in a recess defined by the machine block, the valve member being substantially aligned with a portion of the fluid channel of the dialysis fluid cassette when the dialysis fluid cassette is disposed in the cassette compartment of the dialysis machine, the valve member comprising a deformable area configured to deform outwardly when pressurized fluid is introduced into the valve member,wherein the valve member is configured so that the deformable area obstructs the fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough when the dialysis fluid cassette is disposed in the cassette compartment of the dialysis machine and pressurized fluid is introduced into the valve member.2. The dialysis system of claim 1 , wherein the dialysis machine further comprises a pressurized air source fluidly connected to the valve member such that pressurized air can be delivered from the pressurized air source to the valve member.3. The dialysis system of ...

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Номер записи: 50
16-05-2013 дата публикации

Dialysis Fluid Cassettes and Related Systems and Methods

Номер: US20130118970A1
Автор: Beden Josef, Hahmann Uwe, Herklotz Martin, Lauer Martin, Manke Joachim, Scheunert Peter, Weis Manfred
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

A dialysis fluid cassette that includes a base and a flexible membrane attached to the base. The flexible membrane and the base cooperate to at least partially define a venting chamber and a fluid channel fluidly connected to the venting chamber. 1. A dialysis system , comprising:a dialysis machine defining a cassette compartment and comprising a plurality of valves; and a base; and', 'a flexible membrane attached to the base, the flexible membrane and the base cooperating to at least partially define a venting chamber and a plurality of fluid channels, at least one of the fluid channels being fluidly connected to the venting chamber, and the fluid channels being arranged to align with the valves of the dialysis machine when the dialysis fluid cassette is disposed within the cassette compartment of the dialysis machine such that the valves can be activated to control fluid flow through the dialysis fluid cassette,', 'wherein the venting chamber is configured to permit air to be released from the venting chamber to surroundings external to the dialysis fluid cassette., 'a dialysis fluid cassette configured to be disposed within the cassette compartment, the dialysis fluid cassette comprising'}2. The dialysis system of claim 1 , wherein the dialysis fluid cassette further comprises a permeable membrane attached to the base claim 1 , and the permeable membrane claim 1 , the base claim 1 , and the flexible membrane together define the venting chamber.3. The dialysis system of claim 2 , wherein the permeable membrane is a hydrophobic membrane.4. The dialysis system of claim 2 , wherein the permeable membrane is separate from the flexible membrane.5. The dialysis system of claim 1 , wherein the flexible membrane is configured so that the flexible membrane can be outwardly deformed in a direction away from the base.6. The dialysis system of claim 5 , wherein the base and the flexible membrane are configured so that the venting chamber is substantially spherical when the ...

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Номер записи: 51
16-05-2013 дата публикации

Dialysate Regeneration Unit

Номер: US20130118979A1
Автор: Al-Chalabi Ahmed Nabeel, Kreymann Bernhard, SCHREIBER Catherine Elisabeth
Принадлежит: Hepa Wash GmbH

A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalised dialysate flowing in the second flow path. 11964. A dialysate regeneration unit ( , ) for regenerating a dialysate containing carrier substances , with{'b': '27', 'claim-text': [{'b': 29', '27, 'a first supply unit adapted for adding an acidic fluid () to the dialysate flowing in the first flow path (),'}, {'b': '27', 'a detoxification unit located downstream of the first supply unit, the detoxification unit being adapted for removing toxins from the acidified dialysate flowing in the first flow path (),'}], 'a first flow path () comprising'}{'b': 28', '27', '28, 'claim-text': [{'b': 31', '28, 'a second supply unit adapted for adding an alkaline fluid () to the dialysate flowing in the second flow path (),'}, {'b': '28', 'a further detoxification unit located downstream of the second supply unit, the further detoxification unit being adapted for removing toxins from the alkalised dialysate flowing in the second flow path (), and'}], 'a second flow path () that extends in parallel to the first flow path (), the second flow path () comprising'}an electronic control unit.2. The dialysate regeneration unit of claim 1 , wherein the acidic fluid added ...

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Номер записи: 52
23-05-2013 дата публикации

Device With A Peristaltic Hose Pump And Associated Method

Номер: US20130126404A1
Автор: Gronau Sören, Mueller Ralf
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to an apparatus having at least one hose roller pump, wherein the hose roller pump has at least one pump bed and at least one hose or hose part inserted or insertable into the pump bed, and having at least one pressure detection means which is arranged downstream of the hose roller pump and by means of which the time extent of the pressure of a fluid conveyed by means of the hose roller pump can be determined, and having at least one evaluation means by means of which the occlusion of the hose or hose part inserted or insertable into the pump bed can be monitored with reference to the time difference and/or to the angular difference between at least one maximum and at least one minimum of the determined time extent of the pressure and/or with reference to a local minimum of the determined time extent of the pressure. The invention furthermore in particular relates to a method therefor. 1. An apparatus having at least one hose roller pump , wherein the hose roller pump has at least one pump bed and at least one hose or hose part inserted or insertable into the pump bed , and having at least one pressure detection means which is arranged downstream of the hose roller pump and by means of which the time extent of the pressure of a fluid conveyed by means of the hose roller pump can be determined , and having at least one monitoring means by means of which the occlusion of the hose or hose part inserted or insertable into the pump bed can be monitored with reference to the time difference and/or to the angular difference between at least one maximum and at least one minimum of the determined time extent of the pressure and/or with reference to a local minimum of the determined time extent of the pressure.2. An apparatus in accordance with claim 1 , characterized in that the pressure detection means is arranged downstream of the hose roller pump and upstream of a filter claim 1 , in particular of a dialyzer claim 1 , and the pressure profile ...

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Номер записи: 53
23-05-2013 дата публикации

HEMODIALYSIS SYSTEMS AND METHODS

Номер: US20130126413A1
Автор: van der Merwe Dirk A., Wilt Michael J.
Принадлежит: DEKA Products Limited Partnership

Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be definedwithin one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to, urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices actuated using a control fluid, optionally delivered using to detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments. 1. A hemodialysis system , comprising:a blood flow path through which untreated blood is drawn from a patient and passed through a dialyzer;a dialysate flow path through which dialysate flows from a dialysate supply through the dialyzer, the dialysate flow path and the blood flow path being in fluidic communication; anda pressure device able to urge dialysate in the dialysate flow path to flow into the blood flow path,wherein pressure is controlled within the pressure device such that the pressure of the dialysate exiting the dialyzer is lower than the pressure of the blood exiting the dialyzer.2. The hemodialysis system of claim 1 , wherein the blood flow path is defined by a blood flow cassette.3. The hemodialysis system of claim 1 , wherein the dialysate flow path is defined by at least one cassette.4. A hemodialysis system claim 1 , comprising:a blood flow path through which untreated blood is drawn from a patient and passed through a dialyzer;a dialysate flow path through which dialysate flows from a dialysate supply through the dialyzer, the dialysate flow path and the blood flow path being in fluidic communication; anda pressure device able to urge ...

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Номер записи: 54
23-05-2013 дата публикации

CARDIAC ASSIST DEVICE, INSTRUMENTS, AND METHODS

Номер: US20130131436A1
Автор: Kantrowitz Allen B., Mortis Chris
Принадлежит: L-Vad Technology, Inc.

A cardiac assist device is provided that can be deployed in any region of the aorta by minimally invasive techniques by the way of an inventive fastener that affixes the device to the aorta wall at the site of an aortonomy. The devices and methods described herein allow for improved patient outcome. 1. A fastener for attaching a cardiac assist device to an aorta comprising:an anvil,a staple magazine, said staple magazine removably or fixedly connected to said anvil, anda deployment mechanism, said deployment mechanism removably or fixedly connected to said anvil or said staple magazine,said anvil or said staple magazine associated with a cardiac assist device prior to deploying the cardiac assist device.2. The fastener of wherein said anvil and said staple magazine define an elliptical shape.3. The fastener of further comprising one or more embracers claim 1 , said embracers connected to said anvil or said staple magazine.4. The fastener of wherein said embracers comprise one or more securement points operable for associating said embracer with a shunt.5. The fastener of wherein said embracers extend or are positioned beyond an aortotomy.6. The fastener of wherein further comprising a staple shuttle movably connected to said staple magazine.7. The fastener of further comprising a knife connected to said staple shuttle passing within said staple magazine and said channel of said anvil.8. The fastener of wherein said channel is a space such that the anvil comprises two rectilinear extensions.9. The fastener of wherein said anvil further comprises a brace attaching the distal ends of the extensions.10. The fastener of further comprising a plurality of alignment devices removably connecting said anvil to said staple magazine.11. The fastener of further comprising a second staple shuttle claim 6 , said second staple shuttle further comprising a knife such that activation of both shuttles creates an aortotomy.12. A cardiac assist device for placement in an incision in an ...

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Номер записи: 55
23-05-2013 дата публикации

Automated delivery of medical device support software

Номер: US20130132465A1
Автор: Eric W. Brown
Принадлежит: Zoll Medical Corp

Embodiments of the present invention include a portable medical device with an integrated web server. The portable medical device is configured to establish a communication session with a user device. The integrated web server is configured to load software onto the user computing device for exchanging data with the portable medical device.

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Номер записи: 56
30-05-2013 дата публикации

ADAPTER AND CONNECTION STRUCTURE

Номер: US20130133944A1
Автор: Teraura Makoto, Yoshino Kazutaka
Принадлежит: HI-LEX CORPORATION

An adapter and its connection structure having a plurality of tubes bundled together as one that can be connected to be made shorter in the diameter direction to transport fluid to and from artificial organs and connect electric wires to the artificial organs without changing design of the artificial organs. The adapter and connecting structure connect multi-lumen and single tubes so their passages communicate with each other. The first attachment member, attached to the multi-lumen tube, includes first ports having an outer diameter substantially the same a lumen opening diameter at the end portion of the multi-lumen tube to fit into the lumen openings, and a first cutout corresponding to one of the lumen openings. The second attachment member, attached to the single tube, includes second ports that fit into the lumen of the single tube. The number of the first and second ports is the same. 1. An adapter for connecting a multi-lumen tube and a single tube such that passages of the multi-lumen tube and the single tube communicate with each other , the multi-lumen tube including a plurality of lumens extending in the axial direction , the transverse section of the lumens being oddly formed or deformed , the single tube having a single passage , the adapter comprising:a first attachment member to which the multi-lumen tube is attached, anda second attachment member to which the single tube is attached,the first attachment member includes a plurality of first ports having an outer diameter substantially the same as that of a lumen opening at the end portion of the multi-lumen tube, and a first cutout; the first ports are positioned such that the first ports can fit into the lumen openings when the multi-lumen tube is attached to the first attachment member, and the first cutout is formed in a way so as to correspond to one of the lumen openings when the multi-lumen tube is attached to the first attachment member, andthe second attachment member includes second ports to ...

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Номер записи: 57
06-06-2013 дата публикации

OXYGENATOR WITH INTEGRATED ARTERIAL FILTER INCLUDING FILTER FRAME

Номер: US20130142695A1
Автор: Fiore Gianfranco Beniamino, Giri Alberto, Redaelli Alberto, Reggiani Stefano, Silvestri Claudio
Принадлежит:

An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood. 1. A blood processing apparatus comprising:an apparatus housing having a blood inlet and a blood outlet, the blood inlet extending into an interior of the apparatus housing;a heat exchanger disposed about the blood inlet and in fluid communication therewith;a gas exchanger disposed about the heat exchanger and in fluid communication therewith;a filter housing coupled about the apparatus housing and defining a filter volume between the apparatus housing and the filter housing, the filter volume in fluid communication with the gas exchanger via one or more openings formed within the apparatus housing such that blood exiting the gas exchanger can pass into the filter volume; anda filter frame disposed within the filter housing, the filter frame having one or more ribs and a filter net disposed on the filter frame, the one or more ribs aligned with at least a portion of the one or more openings so as to reduce blood velocity through at least a portion of the filter net;wherein the filter frame has a first annular frame ring having a first diameter and a second annular frame ring having a second diameter greater than the first diameter.2. The blood processing apparatus of claim 1 , wherein the one or more openings comprise a plurality of openings arranged along an arcuate path claim 1 , and the one or more ribs comprise arcuate ribs aligned with the arcuate path.3. The blood processing apparatus of claim 1 , wherein the filter frame has a first annular frame ring having a first diameter claim 1 , a second annular frame ring ...

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Номер записи: 58
06-06-2013 дата публикации

BLOOD PROCESSING UNIT WITH MODIFIED FLOW PATH

Номер: US20130142696A1
Автор: Baiotto Christian, Fiore Gianfranco Beniamino, Redaelli Alberto, Reggiani Stefano
Принадлежит:

A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path. 1. A blood processing apparatus comprising:a housing having a blood inlet and a blood outlet, the blood inlet extending into an interior of the housing;a heat exchanger core arranged within the housing, the heat exchanger core having a core aperture disposed near a first end of the housing, the core configured to impart a radial flow component to blood passing from the blood inlet to an exterior of the heat exchanger core;heat exchanger hollow fibers disposed about the heat exchanger core such that a heat exchanger fluid may flow through the heat exchanger hollow fibers and blood from the core aperture may flow across the heat exchanger hollow fibers;a cylindrical shell extending coaxially about the heat exchanger core, the cylindrical shell including an annular shell aperture disposed near a second end of the housing, the shell aperture configured to impart a longitudinal blood flow component to blood passing to an exterior of the cylindrical shell; andgas exchanger hollow fibers disposed about the cylindrical shell such that gases may flow through the gas exchange hollow fibers and blood passing from the annular shell aperture may flow across the gas exchanger hollow fibers.2. The blood processing apparatus of claim 1 , wherein the outer surface of the heat exchanger core includes one or more radially disposed core ribs configured to impart a radial component to blood flow across the heat exchanger hollow fibers.3. The blood processing apparatus of claim 1 , wherein the cylindrical shell includes an inner surface upon which one or more radially disposed shell ribs are disposed claim 1 , the one or more radially disposed shell ribs ...

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Номер записи: 59
06-06-2013 дата публикации

APPARATUS AND METHOD FOR MONITORING AND CONTROLLING EXTRACORPOREAL BLOOD FLOW RELATIVE TO PATIENT FLUID STATUS

Номер: US20130144110A1
Автор: Mazur Daniel E.
Принадлежит:

A system and method for controlling extracorporeal blood flow in a patient. The system includes a blood pump having a rotor, a plurality of rollers carried by the rotor and a pump chamber extended in tension about the rollers. A sensor measures an operating parameter of the blood pump and a controller, coupled to the sensor, calculates the flow efficiency of the blood pump based on the measured operating parameter. The controller is further configured to display the flow efficiency on the display device, and the operation of the blood pump is adjusted based on the flow efficiency when necessary. 1. A system for controlling extracorporeal blood flow in a patient , the system comprising:a blood pump including a rotor, a plurality of rollers carried by the rotor and a pump chamber extended in tension about the rollers;a sensor configured to measure an operating parameter of the blood pump;a controller coupled to the sensor and determining, based on the operating parameter measured by the sensor, a flow efficiency of the blood pump representing actual stroke volume of the blood pump relative to a maximum stroke volume of the blood pump; anda display device coupled to the controller and configured to display the flow efficiency as determined by the controller.2. The system of claim 1 , wherein the operating parameter is the measured output flow rate of the blood pump.3. The system of claim 2 , wherein the sensor includes a flow sensor configured to measure output flow rate of the blood pump.4. The system of claim 1 , wherein the flow efficiency is determined at least partially based on output flow rate of the blood pump and rotational speed of the rotor.6. The system of claim 1 , wherein the display device is configured to graphically display the flow efficiency.7. The system of claim 1 , wherein the display device is configured to display the rotational speed of the rotor.8. The system of claim 1 , wherein the system includes a user interface coupled to the controller ...

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Номер записи: 60
06-06-2013 дата публикации

METHODS FOR REDUCING THE BLOOD PRIMING VOLUME AND MEMBRANE SURFACE AREA IN MICROFLUIDIC LUNG ASSIST DEVICES

Номер: US20130144266A1
Автор: Borenstein Jeffrey T., Charest Joseph L., Epshteyn Alla, Hsiao James C., Kim Ernest S., Kniazeva Tatiana, Kolachalama Vijaya
Принадлежит: THE CHARLES STARK DRAPER LABORATORY, INC.

A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices. 1. A microfluidic oxygenation device comprising:a first polymer layer defining a first oxygen flow channel therein;a second polymer layer defining a first blood flow channel therein, the first blood flow channel overlapping the first oxygen flow channel, and the first blood flow channel further comprising at least one passive mixing element formed on or within a first wall of the first blood flow channel, the passive mixing element configured to redistribute a fluid flowing through the first blood flow channel within the channel; anda membrane separating the first oxygen flow channel and the first blood flow channel at the overlapping portions of the channels, the membrane allowing communication between the first oxygen flow channel and the first blood flow channel.2. The device of claim 1 , wherein the passive mixing element is one of a straight ridge claim 1 , an angled ridge claim 1 , a chevron canal claim 1 , a dome claim 1 , a cone claim 1 , a pit or a post.3. The device of claim 1 , wherein a first fluid flows through the first oxygen flow channel and a second fluid flows through the first blood flow channel.4. The device of claim 3 , wherein the first fluid is oxygen and the second fluid is deoxygenated blood.5. The device of claim 1 , wherein the height or depth of the passive mixing element is less than about 30% of the height of the first blood flow channel.6. The device of claim 1 , wherein the first wall of the ...

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Номер записи: 61
13-06-2013 дата публикации

CANNULA RING AND RELATED SYSTEMS AND METHODS

Номер: US20130150654A1
Автор: Bearnson Gill, Stanfield Ryan, Woodard John
Принадлежит: World Heart Corporation

Cannula devices and related methods are provided. In accordance with one embodiment, a cannula ring includes a body portion having a substantially cylindrical member defining an opening therethrough. A plurality of anchor arms coupled with the body portion and configured to be positioned in a first, collapsed state and a second, deployed state, wherein the anchor arms each include a free end that is radially displaced from the body portion while in the second, deployed state relative to their positions while in the first, collapsed state. Suture rings and other associated structures and devices are also described. 1. A cannula ring comprising:a body portion including a substantially cylindrical member defining an opening therethrough;a plurality of anchor arms coupled with the body portion and configured to be positioned in a first, collapsed state and a second, deployed state, wherein the anchor arms each include a free end that is radially displaced from the body portion while in the second, deployed state relative to their positions while in the first, collapsed state.2. The cannula ring of claim 1 , wherein the anchor arms extend substantially axially along the body portion while in the first claim 1 , collapsed state.3. The cannula ring of claim 1 , wherein the anchor arms extend substantially circumferentially about the body portion while in the first claim 1 , collapsed state.4. The cannula ring of claim 1 , wherein the anchor arms are formed of a shape memory material.5. The cannula ring of claim 1 , wherein each anchor arm includes a wire structure.6. The cannula ring of claim 1 , wherein at least a portion of each anchor arm is integrally formed with the body portion.7. The cannula ring of claim 1 , further comprising a coupling structure associated with the body portion.8. The cannula ring of claim 7 , wherein the body portion includes a surface feature configured to engage abutting tissue.9. A cannula device comprising:a first structure having a convex ...

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Номер записи: 62
13-06-2013 дата публикации

VASCULAR ACCESS DEVICE FOR HEMODIALYSIS

Номер: US20130150767A1
Автор: Lipkowitz Erin, Tsyrulnykov Eduard
Принадлежит:

Single needle vascular access systems, devices and methods for use in hemodialysis and apheresis procedures. A single needle vascular access device includes a body having an upper and lower passage with both in fluid communication with a vascular dilator. A cannulation needle is guided through the lower passage and vascular dilator to cannulate a graft or fistula. Following cannulation, the dilator is gently introduced into the vessel. The cannulation needle is removed, and a venous tube is introduced through the upper passageway through the vascular dilator and into the fistula or graft. Blood is then removed from the body through the vascular dilator side orifices and returned through the venous line. Depending on the clinical situation, the vascular dilator can be used with one or both needles of a conventional two needle system. In the later case, the vascular dilator may be connected to the dialysis tubes using conventional standard connectors. 1. A method for accessing a dialysis site comprising the steps of:a. cannulating a dialysis access site with a cannulation needle;b. advancing a vascular dilator over the cannulation needle;c. gently advancing the vascular dilator into the dialysis site into direct contact with the blood supply;d. removing the cannulation needle from the dialysis site; ande. connecting the vascular dilator to a dialysis line to provide blood to a blood dialysis unit.2. A method to facilitate bi-directional flow during dialysis through a single access point comprising the steps of:a. positioning a vascular access device having a body with an upper passageway and a lower passageway;b. attaching a vascular dilator to the lower passageway at the front side of the body.c. initiating a cannulation by temporarily passing a cannulation needle through the vascular dilator using the lower passageway within the vascular access device;d. accessing a blood supply by cannulating a wall of a blood vessel with the cannulation needle;e. urging the ...

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Номер записи: 63
20-06-2013 дата публикации

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT, COMPRISING A MEASURING DEVICE FOR DETERMINING THE LUMINESCENCE OF THE SPENT DIALYSATE

Номер: US20130153474A1
Автор: Castellarnau Alex, Frorip Aleksandr, Meibaum Joern, Moll Stefan, Nacke Christoph
Принадлежит: B. Braun Avitum AG

The invention relates to an apparatus for extracorporeal blood treatment having a dialyzer which is divided into a first and a second chamber by means of a semipermeable membrane wherein the first chamber is arranged in a dialysate path and the second chamber can be connected to a patient's blood circulation by means of a blood supply line and a blood discharge line , an inlet for fresh dialysate, an outlet for spent dialysate, a measuring device , wherein the measuring device has at least one radiation source for substantially monochromatic electromagnetic radiation. Thereby the measuring device for determination of a luminescence of the spent dialysate flowing through the outlet has at least one detector system () for detecting the intensity of the electromagnetic radiation generated by luminescence. 115-. (canceled)17. The apparatus according to claim 16 , wherein that the radiation source for emission of electromagnetic radiation is designed in the range of 1 nm to 750 nm claim 16 , particularly in the range of ultra-violet radiation of 1 nm to 380 nm.18. The apparatus according to claim 16 , wherein that the detector system for detection electromagnetic radiation is designed in the range of 1 nm to 750 nm.19. The apparatus according to claim 16 , wherein that the at least one radiation source for the substantially monochromatic electromagnetic radiation has a polychromatic radiation source and a monochromator claim 16 , particularly an optical filter permeable for only a specific wave length or a bandpass filter with one or several pass ranges.20. The apparatus according to claim 16 , wherein that the at least one detector system for detection of the intensity of the electromagnetic radiation generated by luminescence has an optical filter permeable for only a specific wave length or a bandpass filter with one or several pass ranges.21. The apparatus according to claim 16 , wherein that the detector system is designed as a fluorescence detector.22. The ...

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Номер записи: 64
20-06-2013 дата публикации

DIALYSIS SYSTEM INCLUDING PERISTALTIC TUBING PUMPING CASSETTE

Номер: US20130153478A1
Автор: Busby Don, Childers Robert W., Din Shahid, El Sayyid Waleed Mutasem, Kelly Thomas, Roger Rodolfo
Принадлежит:

A hemodialysis system includes: a peristaltic blood pump; a first peristaltic dialysate pump; a second peristaltic dialysate pump; and a fluid cassette including an upper portion and a lower portion, a blood pumping tube extending linearly from the upper portion to the lower portion, the blood pumping tube actuated by the peristaltic blood pump, a first dialysate pumping tube extending linearly from the upper portion to the lower portion, the first dialysate pumping tube actuated by the first dialysate pump, and a second dialysate pumping tube extending linearly from the upper portion to the lower portion, the second dialysate pumping tube actuated by the second dialysate pump. 1. A hemodialysis system comprising:a peristaltic blood pump;a first peristaltic dialysate pump;a second peristaltic dialysate pump; and a blood pumping tube extending linearly from the upper portion to the lower portion of the fluid cassette, the blood pumping tube actuated by the peristaltic blood pump,', 'a first dialysate pumping tube extending linearly from the upper portion to the lower portion of the fluid cassette, the first dialysate pumping tube actuated by the first dialysate pump, and', 'a second dialysate pumping tube extending linearly from the upper portion to the lower portion of the fluid cassette, the second dialysate pumping tube actuated by the second dialysate pump., 'a fluid cassette including an upper portion and a lower portion,'}2. The hemodialysis system of claim 1 , wherein the upper and lower portions of the fluid cassette each include at least one fluid port for fluid flow to or from at least one of the blood pumping tube claim 1 , the first dialysate pumping tube or the second dialysate pumping tube.3. The hemodialysis system of claim 1 , wherein the upper and lower portions of the fluid cassette each define at least one fluid path positioned and arranged to carry fluid to or from at least one of the blood pumping tube claim 1 , the first dialysate pumping tube ...

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Номер записи: 65
20-06-2013 дата публикации

SYSTEMS AND METHODS FOR PRIMING SORBENT-BASED HEMODIALYSIS USING DIALYSIS FLUID

Номер: US20130153495A1
Автор: Busby Don, Childers Robert W., Din Shahid, El Sayyid Waleed Mutasem, Kelly Thomas, Roger Rodolfo
Принадлежит:

A method for priming a hemodialysis treatment includes: providing a sorbent cartridge for cleaning spent dialysate fluid returning from a dialyzer; preparing a batch of dialysate in a quantity commensurate with being recycled through the sorbent cartridge multiple times; priming a dialysate circuit in fluid communication with the dialyzer using the batch of dialysate; and priming a blood circuit in fluid communication with the dialyzer using the batch of dialysate. 1. A method for priming a hemodialysis treatment comprising:providing a sorbent cartridge for cleaning spent dialysate fluid returning from a dialyzer;preparing a batch of dialysate in a quantity commensurate with being recycled through the sorbent cartridge multiple times;priming a dialysate circuit in fluid communication with the dialyzer using the batch of dialysate; andpriming a blood circuit in fluid communication with the dialyzer using the batch of dialysate.2. The method of claim 1 , wherein priming the blood circuit includes reversing a blood pump at least one time.3. The method of claim 1 , wherein preparing the batch of dialysate includes mixing water and concentrate.4. The method of claim 1 , wherein preparing the batch of dialysate includes using on the order of five liters of water to mix the dialysate.5. The method of claim 1 , wherein priming the blood circuit includes venting air through a vent.6. The method of claim 1 , wherein priming the blood circuit includes connecting the ends of arterial and venous lines of the blood circuit together.7. The method of claim 1 , which includes closing and opening at least one valve or line clamp in the blood circuit to prime the blood circuit.8. The method of claim 1 , which includes purifying the dialysate for priming the blood circuit.9. The method of claim 1 , wherein priming the blood circuit includes directing the dialysate at one time in a first direction towards an air trap located in the blood circuit and at another time in a second direction ...

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Номер записи: 66
20-06-2013 дата публикации

Dual Lumen Cannula

Номер: US20130158338A1
Автор: Kelly Patrick A., Lutz Patrick E., Stokes Jerry, SVITEK Robert G.
Принадлежит: CARDIACASSIST, INC.

A dual lumen coaxial cannula assembly includes a first infusion tube having a first elongate body defining a first lumen therethrough and a second drainage tube co-axially aligned with the first infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube. A connector is removably attached to the first infusion tube and the second drainage tube for coupling the dual lumen coaxial cannula to an extracorporeal blood circuit. The first infusion tube and the second drainage tube include a plurality of infusion and drainage apertures, respectively, provided at the distal end and extending through the sidewall of the first infusion tube and the drainage tube, respectively. 1. A dual lumen coaxial cannula assembly comprising:a first infusion tube having a first elongate body defining a first lumen therethrough, the first infusion tube having a proximal end, a distal end, and a sidewall extending circumferentially therebetween;a first connector portion provided at the proximal end of the first infusion tube for coupling the first insertion tube to a connector;a second drainage tube co-axially aligned with said infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube, the second drainage tube having a proximal end, a distal end, and a sidewall extending circumferentially therebetween;a second connector portion provided at the proximal end of the second drainage tube for coupling the second drainage tube to the connector; anda connector removably attached to the first connector portion and the second connector portion for coupling the first infusion tube and the second drainage tube to an extracorporeal blood circuit.2. The dual lumen coaxial cannula assembly of claim 1 , wherein the first infusion tube includes a plurality of infusion apertures provided at the distal end claim 1 , the infusion apertures ...

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Номер записи: 67
20-06-2013 дата публикации

Dialysis machine with electrical insulation for variable voltage input

Номер: US20130158469A1
Автор: Alex Anping Yu, Peter Hopping
Принадлежит: Baxter Healthcare SA, Baxter International Inc

A dialysis machine includes: a source of dialysis solution; a pump configured to pump the dialysis solution; a heater configured to heat the dialysis solution; an electrical input receiving power from a remote power source; and a housing supporting the pump, the heater and the electrical input, the housing including an electrical insulation rated for 240 VAC such that the remote power source can be either 110 or 240 VAC.

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Номер записи: 68
04-07-2013 дата публикации

PREPARATION APPARATUS AND PREPARATION METHOD FOR DIALYSIS FLUID OF VARIABLE BICARBONATE ION CONCENTRATION TYPE, DIALYSATE OF VARIABLE BICARBONATE ION CONCENTRATION TYPE, AND DIALYSIS SYSTEM OF VARIABLE BICARBONATE ION CONCENTRATION TYPE

Номер: US20130168316A1
Автор: Aoyama Hideyuki, Hashimoto Mina, Kikuishi Junya, Noguchi Hiroshi
Принадлежит: TOMITA PHARMACEUTICAL CO., LTD.

Technology for preparing a dialysis fluid capable of flexibly changing bicarbonate ion concentration and maintaining concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels during dialysis according to the disease state of a patient. A three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, with suitable adjustment of the amount of the agent B during dialysis fluid preparation maintains concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly changes the bicarbonate ion concentration therein. Adjusting the ratio between the amount of the agent S and agent B when the dialysate is used also makes it possible to maintain the sodium ion concentration at a constant level or flexibly change the sodium ion concentration. 1. A dialysis fluid preparation apparatus comprising:an agent S container that accommodates an agent S containing sodium chloride and has an outlet,an agent B container that accommodates an agent B containing sodium bicarbonate and has an outlet,an agent A container that accommodates an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate and has an outlet,a mixing part in which the agent S discharged from the agent S container, the agent B discharged from the agent B container, and the agent A discharged from the agent A container are mixed to give a dialysis fluid,an input part that receives an input of dialysis fluid data containing bicarbonate concentration information that specifies a bicarbonate ion concentration in the dialysis fluid, anda control part that controls at least an amount of the agent B supplied to the mixing part based on the dialysis fluid data so as to change the bicarbonate ion concentration in the dialysis fluid, ...

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Номер записи: 69
04-07-2013 дата публикации

METHODS, DEVICES AND SYSTEMS FOR COUNTERPULSATION OF BLOOD FLOW TO AND FROM THE CIRCULATORY SYSTEM

Номер: US20130172660A1
Автор: Spence Paul A.
Принадлежит:

Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a blood flow conduit while the heart is in systole and expel the blood into the blood flow conduit and the artery while the heart is in diastole. 1. A counterpulsation method of assisting the heart of a patient using a pump assist system , the method comprising:coupling a first conduit to the cardiovascular system of the patient without entering the chest cavity or abdominal cavity of the patient,connecting a first port of a pulsatile pump to the first conduit,implanting the pump in the patient without entering the chest cavity or abdominal cavity of the patient,connecting a driver unit to the pump, andcoordinating the operation of the pulsatile pump with the driver unit to suction blood from the cardiovascular system through the first port and the first conduit while the heart is in systole and expel the blood into the first port and the first conduit and the cardiovascular system while the heart is in diastole wherein operation of the pump includes delivering a fluid from the driver unit to the pump.2. The method of claim 1 , wherein coupling the first conduit further comprises coupling to an artery in at least one of the neck claim 1 , shoulder or upper chest region of the patient.3. The method of claim 1 , wherein coupling the first conduit further comprises coupling to an artery in the retroperitoneal region of the patient.4. The method of claim 1 , further comprising:affixing the driver unit to the patient at a location outside the body of the patient,directing the fluid from a location outside the body of the patient to the implanted pump.5. The method of claim 1 , further comprising:coupling a driver conduit from the driver unit to an opposite side of the pump relative to the first conduit, andsupplying the fluid to the pump through the driver conduit.6. The method of claim 1 , ...

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Номер записи: 70
04-07-2013 дата публикации

TRANSSEPTAL CANNULA, TIP, DELIVERY SYSTEM, AND METHOD

Номер: US20130172661A1
Автор: Dusbabek Andrew J., Farnan Robert C., Hudgins Robert G., Jung Elizabeth, Olson Scott A.
Принадлежит: CIRCULITE, INC.

A cannula assembly, further comprising a cannula body for directing blood from the heart of a patient, having distal and proximal ends and a lumen therebetween. A tip coupled to the distal end of the body, the tip having an opening. A pump for drawing blood into the cannula assembly and dispensing the blood from the cannula assembly and into the patient circulatory system. The lumen of the cannula body further comprises a first inner diameter at the proximal end and a second inner diameter at the distal end, the first inner diameter being larger than the second inner diameter. A tapered portion defined as a decrease in inner diameter from the first inner diameter to the second inner diameter between the proximal and distal ends, the tapered portion configured to prevent cavitation of the blood within the cannula. 1. A circulatory assist system , comprising: a cannula body for directing blood from the heart of a patient, having distal and proximal ends and a lumen therebetween; and', 'a tip coupled to the distal end of the body, the tip having an opening;, 'a cannula assembly, further comprisinga pump for drawing blood into the cannula assembly and dispensing the blood from the cannula assembly and into the patient circulatory system; a first inner diameter at the proximal end and a second inner diameter at the distal end, the first inner diameter being larger than the second inner diameter, and', 'a tapered portion defined as a decrease in inner diameter from the first inner diameter to the second inner diameter between the proximal and distal ends, the tapered portion configured to prevent cavitation of the blood within the cannula., 'wherein the lumen of the cannula body further comprises2. The circulatory system of claim 1 , wherein the decrease in inner diameter is constant between the proximal and distal ends.3. The circulatory assist system of claim 2 , wherein the decrease in inner diameter occurs along only a portion of the lumen.4. A circulatory assist ...

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Номер записи: 71
11-07-2013 дата публикации

BI-VENTRICULAR PERCUTANEOUS CABLE

Номер: US20130178932A1
Автор: Cotter Christopher James
Принадлежит: Thoratec Corporation

A percutaneous cable includes a cable body having a first end and second end, the cable body including a sheath adapted to traverse a patient's skin. The cable includes a plurality of conductors disposed within the cable body configured to transmit power and control data between a system controller and two implantable pumps. The cable includes a first connector disposed at the first end of the cable body and coupled to the plurality of conductors, the first connector configured to connect the cable body to the system controller. The cable includes a second connector disposed at the second end of the cable body, the second connector comprising a first set of contacts and a second set of contacts. 1. A method comprising:transmitting power from a controller through a plurality of conductors of a percutaneous cable;bifurcating the power from the plurality of conductors of the percutaneous cable onto a first set of conductors and a second set of conductors via a connector;transmitting power through the first set of conductors to provide power to a first of two implanted ventricular assist pumps; andtransmitting power through the second set of conductors to provide power to a second of the two implantable ventricular assist pumps.2. The method of claim 1 , wherein transmitting power through the first set of conductors includes transmitting power to a first pump cable connected to the first of the two implanted ventricular assist pumps claim 1 , and wherein transmitting power through the second set of conductors includes transmitting power to a second pump cable connected to the second of the two implanted ventricular assist pumps.3. The method of claim 1 , wherein a biocompatible sheath along a portion of a length of the percutaneous cable traverses skin.4. The method of claim 1 , wherein the percutaneous cable traverses skin and is releasably connected to the connector.5. The method of claim 1 , wherein the percutaneous cable traverses skin through a single site.6. The ...

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Номер записи: 72
18-07-2013 дата публикации

Acid Zirconium Phosphate and Alkaline Hydrous Zirconium Oxide Materials For Sorbent Dialysis

Номер: US20130180905A1
Автор: Wong Raymond June-Hin
Принадлежит: Fresenius Medical Care Holdings, Inc.

A combination of acid zirconium phosphate and alkaline hydrous zirconium oxide are utilized as ion-exchange materials, for example, in sorbent dialysis. The combination provides for dialysate regeneration while maintaining constant and controlled levels of Na, HCO, and pH. 130-. (canceled)31. An apparatus for conducting dialysis comprising a sorbent cartridge , and a dialyzer in fluid communication with the sorbent cartridge , wherein spent dialysate passes from the dialyzer to and through the sorbent cartridge , and wherein said sorbent cartridge comprising a layer of a mixture of acid zirconium phosphate (AZP) and alkaline hydrous zirconium oxide (NaHZO) in the sorbent cartridge , and wherein said acid zirconium phosphate is the only form of zirconium phosphate present in said layer.32. The apparatus of claim 31 , wherein the spent dialysate is spent hemodialysate claim 31 , spent peritoneal dialysate claim 31 , or combinations thereof.33. The apparatus of claim 31 , wherein the dialyzer is in fluid communication with the blood of a patient.34. A dialysis system comprising a sorbent cartridge and a source of spent dialysate claim 31 , wherein the source of the spent dialysate is in fluid communication with the sorbent cartridge and the spent dialysate passes to and through the sorbent cartridge claim 31 , and wherein said sorbent cartridge comprising a layer of a mixture of acid zirconium phosphate (AZP) and alkaline hydrous zirconium oxide (NaHZO) in the sorbent cartridge claim 31 , and wherein said acid zirconium phosphate is the only form of zirconium phosphate present in said layer.35. The dialysis system of claim 34 , wherein the spent dialysate passes through the sorbent cartridge at a rate of about 100 ml/min to about 550 ml/min.36. The dialysis system of claim 34 , wherein the spent dialysate is regenerated.37. The dialysis system of claim 36 , wherein the spent dialysate is regenerated to a pH level about equal to that of fresh dialysate.38. The dialysis ...

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Номер записи: 73
18-07-2013 дата публикации

PRESSURE ACTUATED SINGLE-LUMEN BLOOD PUMPING DEVICE

Номер: US20130184514A1
Автор: KARMON YORAM, van Loon Jan-Paul
Принадлежит: PULSECATH B.V.

A pressure actuated single-lumen blood pumping device has a housing () having a wall () bounding a pressure transfer chamber (). The housing () bounds a pressure transfer port () for connection to a pressure source, the pressure transfer port () communicating with the pressure transfer chamber () for alternatingly transferring over pressure and under pressure from the pressure source to the pressure transfer chamber (). A flexible tubular membrane () is arranged in the pressure transfer chamber (). A blood transfer conduit () passes through the wall () bounding the pressure transfer chamber () and the blood transfer conduit () connects to opposite ends () of the flexible tubular membrane (). 1. A pressure actuated single-lumen blood pumping device comprising:a housing having a wall bounding a pressure transfer chamber, the housing comprising a pressure transfer port for connection to a pressure source, the pressure transfer port communicating with the pressure transfer chamber for alternatingly transferring overpressure and under pressure from the pressure source to the pressure transfer chamber;a flexible tubular membrane in the pressure transfer chamber, the flexible tubular membrane having opposite ends and bounding a blood chamber; anda blood transfer conduit passing through the wall bounding the pressure transfer chamber and having a single-lumen portion branching into lumen branches;wherein the blood transfer conduit connects to the opposite ends of the flexible tubular membrane; andwherein the blood transfer conduit has a second proximal end at an end of a second one of the lumen branches, a first one of the proximal ends being at an end of a first one of the lumen branches and coupled to a first one of the ends of the elastic tubular membrane and the second proximal end being coupled to the second end of the elastic tubular membrane.2. The pumping device according to claim 1 , wherein the flexible tubular membrane has a curved shape.3. (canceled)4. The ...

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Номер записи: 74
18-07-2013 дата публикации

DOUBLE BALLOON PUMP CARDIAC ASSIST DEVICE AND RELATED METHOD OF USE

Номер: US20130184515A1
Автор: Ovil Ace, Ovil Yoel, Ovil Yotam
Принадлежит:

A system and method for cardiac assist of a heart in a beating stage comprising a double balloon catheter having a proximal end and a distal end, the catheter having at least one lumen; an inflatable intra-ventricular balloon mounted on the catheter near the distal end of the catheter, the balloon having a lumen in fluid communication with the lumen of the catheter and being configured for inflation in a ventricle; and an intra-aortic balloon mounted on the catheter proximally to the intra-ventricular balloon; a control unit comprising a bidirectional pump; a fluid reservoir; and a processor configured to activate the pump; wherein the proximal end of the catheter is configured for attachment to the control unit to form a fluid conduction system in which fluid is configured to be pumped by the pump between the fluid reservoir and the intra-ventricular balloon and the intra-aortic balloon; and systolic augmentation comprising a new pressure wave which is generated when said balloon is inflated at the end of the slow ejection phase of the beating heart, such that any residual volume of blood left in said ventricle is displaced. 2. The system according to claim 1 , wherein said slow ejection phase corresponds to the ascending part of the ECG-T wave of the beating heart.3. The system according to claim 1 , wherein said double balloon pump catheter is configured to be introduced into the left ventricle through the femoral artery or into the aorta through a left mini non-invasive thoraectomy.4. The system according to further comprising one or more electrodes mounted on the catheter near the distal end generating a signal indicative of electrical activity of the heart and wherein the processor is configured to receive the electrical signals.5. The system according to claim 4 , wherein the proximal part of said electrodes can be connected to a pacemaker box.6. The system according to wherein the processor is configured to analyze the signal indicative of electrical ...

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Номер записи: 75
25-07-2013 дата публикации

HEMODIALYSIS AND PERITONEAL DIALYSIS SYSTEMS HAVING ELECTRODIALYSIS AND ELECTRODEIONIZATION CAPABILITIES

Номер: US20130186759A1
Автор: Chen Ye, Ding Yuanpang Samuel, Lin Rongsheng, Lo Ying-Cheng, Miller Joshua, Rohde Justin, White James M.
Принадлежит:

Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodialysis and electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source, an ED/EDI unit. The carbon source, urease source, and/or the ED/EDI unit can be in the form of removable cartridges. 1. A dialysis fluid system recycling used dialysis fluid , the system comprising:a carbon source;a urease source in fluid communication with the carbon source; and (i) an ED component, and', '(ii) an EDI component in fluid communication with the ED component., 'an electrodialysis/electrodionization (“ED/EDI”) unit in fluid communication with at least one of the carbon and urease sources, the ED/EDI unit including'}2. The dialysis fluid system of claim 1 , which includes an ion exchange unit operating with the ED/EDI unit to recycle used dialysis fluid.3. The dialysis fluid recycling system of claim 1 , which includes a concentrate metering source located downstream of the ED/EDI unit.4. The dialysis fluid recycling system of claim 1 , wherein at least a portion of fluid within the ED/EDI unit is recirculated back into the ED/EDI unit.5. The dialysis fluid recycling system of claim 1 , wherein the ED unit includes multiple ED units.6. A hemodialysis system recycling used dialysis fluid claim 1 , the hemodialysis system comprising:a blood circuit and a dialysis fluid circuit in fluid communication with a dialyzer;a carbon source in the dialysis fluid circuit;a urease source in fluid communication with the carbon source; andan electrodialysis/electrodionization (“ED/EDI”) unit in fluid communication with at least one of the carbon and urease sources and, the ED/EDI unit including an ED component and an EDI component in fluid communication with the ED component.7. The hemodialysis system of claim 6 , which includes an ion exchange unit in the dialysis fluid circuit.8. The hemodialysis system of claim 6 , which includes a concentrate ...

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Номер записи: 76
25-07-2013 дата публикации

METHOD FOR POWERING PORTABLE DIALYSIS MACHINE

Номер: US20130186828A1
Автор: Bedingfield John A., Kienman Richard E., Lauman Brian C.
Принадлежит:

A method for operating a medical fluid machine, the method comprising: (i) if alternating current (“AC”) power is available, charging a battery, if needed, and powering the medical fluid machine with the AC power; and (ii) if AC power is not available (a) if fuel cell power is available, charging the battery, if needed, and powering the medical fluid machine with the fuel cell power; and (b) if fuel cell power is not available, powering the medical fluid machine using battery power until the AC power or fuel cell power is available. 1. A method for operating a medical fluid machine , the method comprising:(i) if alternating current (“AC”) power is available, charging a battery, if needed, and powering the medical fluid machine with the AC power; and (a) if fuel cell power is available, charging the battery, if needed, and powering the medical fluid machine with the fuel cell power; and', '(b) if fuel cell power is not available, powering the medical fluid machine using battery power until the AC power or fuel cell power is available., '(ii) if AC power is not available'}2. The method of claim 1 , wherein if fuel cell power is not available claim 1 , further powering a fuel cell using the battery power.3. The method of claim 1 , which includes sizing the medical fluid machine so as to be worn by a patient.4. The method of claim 1 , wherein the medical fluid machine is a peritoneal dialysis machine or a hemodialysis machine.5. The method of claim 1 , which includes converting the AC power to direct current (“DC”) power if the AC power is available claim 1 , charging the battery and powering the medical fluid machine using DC power created from the AC power.6. The method of claim 5 , which includes reducing power to a heating element if the heating element would receive more power than needed.7. The method of claim 1 , which includesgenerating electricity from the fuel cell power, the AC power or the battery power; andstoring the electricity for use with the medical ...

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Номер записи: 77
25-07-2013 дата публикации

BUFFERED COMPOSITIONS FOR DIALYSIS

Номер: US20130186829A1
Автор: Callan Robin, Cole James J., Van Schalkwijk Walter A.
Принадлежит: ADVANCED RENAL TECHNOLOGIES

Acid concentrates, and dialysate compositions prepared therefrom, contain citric acid and an effective amount of a buffering agent selected from acetate and/or lactate. The buffering agent allows a physiologically acceptable amount of citrate to maintain the desired pH of the dialysate. 1. A method of forming a dialysate precursor composition comprising mixing treated water , chloride , citrate , at least one buffering anion selected from acetate and/or lactate , and at least one physiologically-acceptable cation to provide a composition having chloride at a concentration ranging from about 1 ,000 to about 7 ,000 mEq/L , citrate at a concentration ranging from about 20 to about 900 mEq/L , and at least one buffering anion selected from acetate and lactate at a concentration ranging from about 0.01 to about 150 mEq/L.2. The method of comprising citrate at a concentration ranging from about 70 to about 150 mEq/L.3. The method of wherein the buffering anion is acetate at a concentration ranging from about 0.3 to about 125 mEq/L.4. The method of wherein the buffering anion is lactate at a concentration ranging from about 0.3 to about 125 mEq/L.5. The method of wherein the physiologically-acceptable cation is selected from a group consisting of hydrogen claim 1 , sodium claim 1 , potassium claim 1 , calcium claim 1 , magnesium claim 1 , and combinations thereof.6. The method of claim 1 , further comprising mixing the dialysate precursor with a sugar selected from glucose claim 1 , poly(glucose) and fructose claim 1 , at a concentration of less than about 2 claim 1 ,700 g/L.7. The method of wherein the citrate is in the form of at least one of citric acid or a salt thereof selected from a group consisting of sodium dihydrogen citrate claim 1 , disodium hydrogen citrate claim 1 , trisodium citrate claim 1 , trisodium citrate dihydrate claim 1 , potassium dihydrogen citrate claim 1 , dipotassium hydrogen citrate claim 1 , calcium citrate claim 1 , and magnesium citrate.8. ...

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Номер записи: 78
25-07-2013 дата публикации

Methods Of Synthesizing Hydrous Zirconium Oxide And Other Oxides

Номер: US20130190168A1
Автор: Fontenelle Lucas, Wong Raymond J.
Принадлежит: Fresenius Medical Care Holdings, Inc.

The present invention relates to sol gel hydrous metal oxide particles, such as hydrous zirconium oxide particles, their manufacture, and their use in such applications as sorbent dialysis. 1. Hydrous metal oxide particles comprising:at least one hydrous metal oxide; andat least one oxygen-containing additive;wherein the oxygen-containing additive comprises at least one polar group or a charged group or both; andwherein the oxygen-containing additive is present as a soluble ligand that forms a complex with a metal ion of the hydrous metal oxide.2. The hydrous metal oxide particles of claim 1 , wherein a metal ion of the hydrous metal oxide comprises a zirconium ion claim 1 , a hafnium ion claim 1 , a titanium ion claim 1 , a tin ion claim 1 , or a lead ion.3. The hydrous metal oxide particles of claim 1 , wherein the metal ion is a zirconium ion.4. The hydrous metal oxide particles of claim 1 , wherein the oxygen-containing additive comprises a molecular weight from about 50 to about 500 Da.5. The hydrous metal oxide particles of claim 1 , wherein the oxygen-containing additive comprises a surfactant.6. The hydrous metal oxide particles of claim 1 , wherein the oxygen-containing additive comprises a dispersant.7. The hydrous metal oxide particles of claim 6 , wherein the dispersant is tartaric acid.8. The hydrous metal oxide particles of claim 1 , wherein the oxygen-containing additive comprises acetic acid claim 1 , soda ash claim 1 , polyvinyl alcohol claim 1 , tartaric acid claim 1 , EDTA claim 1 , glycerol claim 1 , sodium dodecyl sulfate claim 1 , or any combination thereof.9. The hydrous metal oxide particles of claim 1 , wherein the hydrous metal oxide particles have a particle size range of from about 2 to about 200 microns.10. The hydrous metal oxide particles of claim 1 , wherein the hydrous metal oxide particles have a particle size distribution of less than 25% in the range of less than about 25 microns claim 1 , less than 5% in the range of more than ...

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Номер записи: 79
25-07-2013 дата публикации

DRIVELINE CABLE ASSEMBLY

Номер: US20130190551A1
Автор: Baker James H., Callaway Justin Aron, Wagers Matthew
Принадлежит:

A blood pump assembly includes a blood pump configured for implantation and a cable assembly for providing power and control signals to the blood pump. The cable assembly includes a strain relief assembly and a driveline. The strain relief assembly secures the cable assembly to the blood pump and has an outer surface that is curved along a longitudinal extent of the strain relief assembly at least along an outer peripheral side of the outer surface. The strain relief assembly defines a compartment and an internal passage that leads to the compartment. The driveline houses a plurality of conductors that extend from the driveline through the internal passage and into the compartment. 1. A blood pump assembly comprising:a blood pump configured for implantation; and the strain relief assembly securing the cable assembly to the blood pump and having an outer surface that is curved along a longitudinal extent of the strain relief assembly at least along an outer peripheral side of the outer surface, the strain relief assembly defining a compartment and an internal passage that leads to the compartment, and', 'the driveline housing a plurality of conductors that extend from the driveline through the internal passage and into the compartment., 'a cable assembly secured to the blood pump for providing power and control signals to the blood pump, the cable assembly including a strain relief assembly and a driveline,'}2. The blood pump assembly of claim 1 , wherein the strain relief assembly is sized and positioned to lie entirely within a transverse footprint of the blood pump.3. The blood pump assembly of claim 1 , wherein the outer surface of the strain relief assembly has an inner peripheral side opposite the outer peripheral side claim 1 , the inner peripheral side facing the blood pump and being spaced apart from the blood pump.4. The blood pump assembly of claim 3 , wherein the blood pump has an outer surface facing the inner peripheral side claim 3 , and the inner ...

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Номер записи: 80
01-08-2013 дата публикации

CONTROL OF A WATER DEVICE VIA A DIALYSIS MACHINE USER INTERFACE

Номер: US20130193041A1
Автор: Rohde Justin B.
Принадлежит:

A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface. 1. A home medical device system comprising:a home therapy machine for performing a home therapy on a patient;a user interface operably connected to the home therapy machine, the user interface receiving operator inputs;a water treatment device in fluid communication with the home therapy machine; anda data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.2. The home medical device system of claim 1 , wherein the water treatment device transmits to the home therapy machine at least one of: (i) state information claim 1 , (ii) component life information claim 1 , (iii) self test results claim 1 , (iv) alert information or (v) version information.3. The home medical device system of claim 2 , wherein the user interface displays at least one of: (i) the state information claim 2 , (ii) the component life information claim 2 , (iii) the self test results claim 2 , (iv) the alert information or (v) the version information.4. The home medical device system of claim 1 , in which the home therapy machine transmits to the water treatment device at least one of: (i) state change requests claim 1 , (ii) status ...

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Номер записи: 81
01-08-2013 дата публикации

BALANCED FLOW DIALYSIS MACHINE

Номер: US20130193073A1
Автор: Busby Donald D., Childers Robert W., Ding Yuanpang Samuel, Hogard Michael E., Holian Katherine M., Jablonski Mark E., Kelly Thomas D., Lo Ying-Cheng, Maliekkal Shincy J., Roger Rodolfo G., Smith Donald A., Yardimci Atif M.
Принадлежит:

A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber. 1. A renal therapy system comprising:a dialyzer;a balancing system configured to equalize flow volume of renal failure therapy fluid flowing to the dialyzer and from the dialyzer;a controller configured to control the fresh renal therapy fluid and the spent renal therapy fluid for the balancing system so that a pressure of the fresh renal failure therapy fluid flowing to the balancing system is equal to a pressure of the spent renal failure therapy fluid flowing to the balancing system.2. The renal therapy system of claim 1 , which includes a cassette claim 1 , the cassette including the balancing system.3. The renal therapy system of claim 1 , which includes a fresh renal therapy fluid pressure sensor and a spent renal therapy fluid pressure sensor operating with the controller to control the fresh and spent renal therapy fluid flow.4. The renal therapy system of claim 1 , wherein the controller operates a plurality of valves to control the fresh and spent renal therapy flow.5. The renal therapy system of claim 1 , wherein the balancing system includes at least one fresh and spent rigid chamber and a member that is moved back and forth within the rigid chamber by the fresh and spent renal therapy fluids.6. A renal therapy system comprising:a dialyzer;a balancing system configured to equalize flow volume of renal failure therapy fluid flowing to the dialyzer and from the dialyzer;a controller configured to control the fresh renal therapy fluid and the spent renal therapy fluid for the balancing system so that a pressure of the fresh renal failure therapy fluid flowing from the balancing system is equal to a pressure of ...

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Номер записи: 82
01-08-2013 дата публикации

Catheter

Номер: US20130197418A1
Автор: Catalin Toma, George Oliviu Angheloiu, John A. Kellum, William D. Anderson
Принадлежит: University of Pittsburgh

In one aspect, the invention provides a device comprising a catheter. In another aspect, the invention provides a method of removing an agent from blood.

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Номер записи: 83
01-08-2013 дата публикации

NANOPOROUS MEMBRANES, DEVICES, AND METHODS FOR RESPIRATORY GAS EXCHANGE

Номер: US20130197420A1
Автор: BASKARAN Harihara, Fissell, Goldman Ken, IV WILLIAM H., Roy Shuvo
Принадлежит:

One aspect of the present invention relates to a silicon nanoporous membrane for oxygenating blood. The nanoporous membrane includes a first major surface, a second major surface, and a plurality of pores extending between the first and second major surfaces. The first major surface is for contacting a gas. The second major surface is for contacting blood and is oppositely disposed from said first major surface. The first and second major surfaces define a membrane thickness. Each of the pores is defined by a length, a width, and a height. Each of the pores is separated by a uniform interpore distance. 1. A silicon nanoporous membrane for oxygenating and/or removing carbon dioxide from blood , said nanoporous membrane comprising:a first major surface for contacting a gas;a second major surface for contacting blood and being oppositely disposed from said first major surface, said first and second major surfaces defining a membrane thickness; anda plurality of pores extending between said first and second major surfaces, each of said pores being defined by a length, a width, and a height, each of said pores being separated by a uniform interpore distance2. The nanoporous membrane of claim 1 , wherein each of said pores has the same bubble point to prevent or mitigate membrane failure through pore wetting.3. The nanoporous membrane of claim 1 , wherein said nanoporous membrane thickness is about 0.1 micrometer to about 50 micrometers.4. The nanoporous membrane of claim 3 , wherein said nanoporous membrane has a flattened claim 3 , sheet-like configuration.5. The nanoporous membrane of claim 1 , wherein each of said pores is slit-shaped.6. The nanoporous membrane of claim 1 , wherein each of said pores has a symmetrical cross-sectional profile.7. The nanoporous membrane of claim 6 , wherein each of said pores has a rectangular cross-sectional profile.8. The nanoporous membrane of claim 1 , wherein each of said pores has an asymmetrical cross-sectional profile.9. The ...

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Номер записи: 84
08-08-2013 дата публикации

HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME

Номер: US20130199998A1
Автор: Kelly Thomas D., Lyu Suping, Meyer Thomas E., Pudil Bryant J.
Принадлежит: Medtronic, Inc.

Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge. 1. A system for performing kidney replacement treatment or for performing kidney replacement treatment with enhanced convective clearance and reduced blood clotting risk , comprising:a hemodialysis system having a controlled compliance dialysis circuit, a dialyzer with a dialysis membrane, a blood inlet end for receiving blood, a blood outlet end for allowing blood out of the dialyzer, a dialysate inlet end for receiving dialysate and a dialysate outlet end for allowing dialysate out of the dialyzer, wherein the blood and the dialysate contact different sides of the dialysis membrane;an extracorporeal circuit having a conduit for receiving blood from a subject and a conduit for returning blood to the subject, and a blood pump for conveying blood from the subject, to the dialyzer and back to the subject;a dialysis circuit having a sorbent cartridge for removing at least one impurity or waste species from the dialysate, one or more conduits for conveying dialysate ...

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Номер записи: 85
08-08-2013 дата публикации

BLOOD PUMP FOR THE INVASIVE APPLICATION WITHIN A BODY OF A PATIENT

Номер: US20130204362A1
Автор: Scheckel Mario, Toellner Thomas
Принадлежит: ECP ENTWICKLUNGSGESELLSCHAFT MBH

The invention relates to a blood pump for the invasive application within a body of a patient comprising a rotor () which is drivable about an axis of rotation and is radially compressible or expandable and which has a hub () and at least one impeller blade () fastened thereto, as well as comprising a housing (′) which is compressible or expandable in the radial direction by an axial stretching or axial compression. The object of making both the rotor and the housing expandable and compressible in as simple a manner as possible is achieved in accordance with the invention in that a control body () is provided which passes through the hub () in the longitudinal direction and which is coupled to the housing on the distal side of the rotor such that it exerts pulling and/or compression forces on the housing by a movement in the longitudinal direction with respect to the housing. 115-. (canceled)16. A blood pump for the invasive application within a body of a patient comprising a rotor which is drivable about an axis of rotation , which is radially compressible and expandable and which has a hub and at least one impeller blade thereto as well as comprising a housing which is compressible or expandable in the radial direction by a axial stretching or axial compression , wherein a control body passing through the hub in the longitudinal direction is provided which is coupled to the housing on the distal side of the rotor such that it exerts pulling and/or compression forces onto the housing by a movement in the longitudinal direction with respect to the housing.17. The blood pump in accordance with claim 16 , wherein the control body rotates with the rotor;or in that the control body is stationary with respect to the rotor;and/or in that the control body is axially non-displaceably connected to the housing.18. The blood pump in accordance with claim 17 , wherein the control body passes through the housing wall and has at its distal side an abutment body which exerts a ...

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Номер записи: 86
15-08-2013 дата публикации

Tubular fiber membrane with nanoporous skin

Номер: US20130206673A1
Автор: Jackie Y. Ying, Min Hu, Ming Ni, Rensheng Deng
Принадлежит: Agency for Science Technology and Research Singapore

A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.

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Номер записи: 87
15-08-2013 дата публикации

Compact heat exchanger for veno-venous perfusion-induced systemic hyperthermia systems

Номер: US20130211483A1
Автор: Dongfang Wang, Joseph B. Zwischenberger
Принадлежит: University of Kentucky Research Foundation

A compact heat exchanger for veno-venous perfusion-induced hyperthermia includes an integral pneumatic pump and a hollow tubule heat exchange array. A veno-venous perfusion-induced hyperthermia system incorporating the compact heat exchanger is described. The heat exchanger provides a compact, efficient design allowing a lesser heat exchanging surface area and lesser required pumping power compared to conventional systems. In turn, the system provides a shorter blood circuit compared to conventional systems, allowing maintaining a lower blood temperature than such conventional systems while supplying sufficiently heated blood to patient visceral organs to provide a therapeutic effect, such as in supplementing chemotherapy drugs.

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Номер записи: 88
22-08-2013 дата публикации

MODULAR HEMODIALYSIS SYSTEM

Номер: US20130213890A1
Автор: Kelly Thomas D., Lyu Suping, Meyer Thomas E., Pudil Bryant J.
Принадлежит: Medtronic, Inc.

Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module. 1. A system , comprising:an extracorporeal module having a blood pump that pumps blood from a subject through an extracorporeal circuit, the extracorporeal circuit having one or more attachments for fluidly connecting to either a portable treatment module or to a urea removal module; anda dialyzer having a dialysis membrane where blood is conveyed from the subject to the dialyzer and back to the subject,wherein a flux of fluid moving between the extracorporeal circuit and either the portable module or the urea removal module is changed by the rate at which a control pump operates.2. The system of claim 1 , wherein the extracorporeal module is connected to one or more of the portable treatment module and the urea removal module claim 1 , wherein the portable treatment module comprises:a first sorbent cartridge consisting essentially of activated carbon and zirconium oxide,a first dialysis circuit and a first dialysate pump for conveying a dialysate from the first sorbent cartridge to the dialyzer and back to the first sorbent cartridge, wherein the dialyzer has a dialysis membrane where blood is conveyed from a subject to the dialyzer, contacted with the dialysis membrane and conveyed back to ...

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Номер записи: 89
22-08-2013 дата публикации

METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES

Номер: US20130213891A1
Автор: Karoor Sujatha
Принадлежит:

A dialysis system comprising: a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication sorbent cartridge and the storage container; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zirconium phosphate layer. 1. A dialysis system comprising:a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer;a storage container in fluid communication with the sorbent cartridge;a pump in fluid communication with the sorbent cartridge and the storage container; anda control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium ...

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Номер записи: 90
22-08-2013 дата публикации

FLUID PUMPING VENTRICULAR ASSIST DEVICE AND COMPONENTS WITH STATIC SEAL

Номер: US20130217953A1
Автор: Tovar Lopez Francisco Javier
Принадлежит: VITALMEX INTERNACIONAL S.A. DE C.V.

A ventricular assist device (VAD) having static seal structure for a pump housing which includes a support structure, a first sealing element, and a second sealing element. The support structure circumscribes a pump chamber and includes a first sealing surface, an opposing second sealing surface, and a fluid transfer end interposed between the sealing surfaces. The support structure provides a fluid flow path running through the fluid transfer end and into the pump chamber via an inlet bore and from the pump chamber back through the fluid transfer end via an outlet bore. The first sealing element is disposed on the first sealing surface, and the second sealing element is disposed on the second sealing surface. The sealing elements are configured for forming sealing interfaces in the pump housing, establishing a static seal that isolates the pump chamber from an environment external to the fluid pump housing. 130.-. (canceled)31. A static seal structure for a fluid pump housing , comprising:a support structure circumscribing a pump chamber, the support structure including a first sealing side, a second sealing side opposite to the first sealing side, a first opening located at the first sealing side, a second opening located at the second sealing side, a first sealing surface circumscribing the first opening, a second sealing surface circumscribing the second opening;a first sealing element disposed on the first sealing surface; anda second sealing element disposed on the second sealing surface,wherein the first sealing element and the second sealing element are configured for forming sealed interfaces between the support structure and surfaces of the fluid pump housing when assembled in the fluid pump housing.32. The static seal structure of claim 31 , wherein the support structure further includes a fluid transfer end interposed between the first sealing side and the second sealing side claim 31 , a fluid inlet bore formed through the fluid transfer end claim 31 , ...

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Номер записи: 91
22-08-2013 дата публикации

HEART ASSISTANCE DEVICE

Номер: US20130218268A1
Автор: Gmeiner Heinrich, KUNZ Andreas, Schiller Wolfgang, Schmid Thomas, Vodermayer Bernhard, Wimmer Alexandra
Принадлежит:

A heart assistance device for the pulsatile delivery of blood. A first and a second pump chamber are provided, and also a pump. Both pump chambers each have a fluid chamber and a blood-carrying chamber. By means of the pump, each fluid chamber can be filled with a fluid or emptied thereof in such a way that an expansion or contraction of the fluid chamber takes place. During the expansion of the fluid chamber of one pump chamber, a compression of the blood-carrying chamber of the same blood chamber takes place. 1. A heart assistance device for the pulsatile delivery of blood , comprisinga first and a second pump chamber, anda pump,each of the pump chambers comprising a fluid chamber and a blood-carrying chamber, and each fluid chamber being adapted to be filled with or emptied of a fluid by means of the pump such that an expansion or contraction of the fluid chamber occurs,the blood-carrying chamber of the same pump chamber is compressed upon the expansion of the fluid chamber of said respective pump chamber,whereinthe pump is designed as a roller cell pump or a vane pump.2. The heart assistance device of claim 1 , wherein the pump operates in a reversing mode.3. The heart assistance device of claim 1 , wherein the pump is operated in one direction claim 1 , the heart assistance device comprising valves for redirecting the fluid flow.4. The heart assistance device of claim 1 , wherein the heart assistance device comprises two roller cell or vane pumps claim 1 , each being connected with said respective fluid chamber and alternately delivering in opposed directions claim 1 , the quantity of fluid delivered into the fluid chambers being adjustable through the rotational speed of the first or the second roller cell or vane pump.5. The heart assistance device of claim 1 , comprising a housing claim 1 , wherein the two pump chambers and the pump are arranged in the housing and the pump is arranged between the pump chambers.6. The heart assistance device of claim 1 , ...

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Номер записи: 92
29-08-2013 дата публикации

Portable Dialysis Machine with Improved Reservoir Heating System

Номер: US20130220907A1
Автор: Fulkerson Barry Neil, Huang Alec, Kelly Brian Thomas, Nolan Tam
Принадлежит: Fresenius Medical Care Holdings, Inc.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan. 1. A dialysis machine having a reservoir unit wherein said reservoir unit comprises:a. a first housing having an external surface and an internal surface and defining a first volume adapted to hold a fluid therein;b. a second housing having an external surface and an internal surface and defining a second volume adapted to house the first housing with a space between the external surface of the first housing and the internal surface of the second housing;c. a heating element positioned within the space between the external surface of the first housing and the internal surface of the second housing; andd. a first plurality of electrical contacts attached to the external surface of the second housing and electrically coupled to the heating element.2. The dialysis machine of claim 1 , wherein said first housing is fused to said second housing.3. The dialysis machine of claim 1 , wherein said heating element is a heating pad and wherein said heating pad is rated in a range from 300 W to 600 W.4. The dialysis machine of claim 3 , wherein said heating pad is configured to heat from 1 to 6 liters of a fluid claim 3 , located within said first volume claim 3 , to a temperature within a range of 36 to 39 degrees C. within 15 to 45 minutes.5. The dialysis machine of claim 1 , wherein said first housing is a pan and wherein the first volume is at least ...

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Номер записи: 93
29-08-2013 дата публикации

Rotary Pump with Hydrodynamically Suspended Impeller

Номер: US20130225910A1
Автор: Geoffrey Douglas Tansley, John Campbell Woodard, Peter Andrew Watterson
Принадлежит: Thoratec LLC

A pump assembly 1, 33, 200 adapted for continuous flow pumping of blood. In a particular from the pump 1, 200 is a centrifugal pump wherein the impeller 100, 204 is entirely sealed within the pump housing 2, 201 and is exclusively hydrodynamically suspended therein as the impeller rotates within the fluid 105 urged by electromagnetic means external to the pump cavity 106, 203. Hydrodynamic suspension is assisted by the impeller 100, 204 having deformities therein such as blades 8 with surfaces tapered from the leading edges 102, 223 to the trailing edges 103, 224 of bottom and top edges 221, 222 thereof.

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Номер записи: 94
29-08-2013 дата публикации

PORTABLE CONTROLLER WITH INTEGRAL POWER SOURCE FOR MECHANICAL CIRCULATION SUPPORT SYSTEMS

Номер: US20130225911A1
Автор: Bolyard Nathan J., Evans Don William Eldon, Maniak Jeremy J.
Принадлежит: MINNETRONIX, INC.

A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort. 1. A kit comprising a plurality of rechargeable batteries of a portable external device of a mechanical circulation support (MCS) system comprising an implantable pump , the kit comprising:an external energy dense rechargeable battery, wherein the external battery is configured to be removably connected to a housing of the portable external device; andan internal power dense rechargeable battery, wherein the internal battery is configured to be arranged completely within the housing,wherein each of the external and internal batteries is configured to power the implantable pump.2. The kit of claim 1 , wherein the external battery claim 1 , when connected to the housing claim 1 , forms an integral portion of the housing.3. The kit of claim 1 , wherein the external battery comprises a case within which one or more battery cells are arranged claim 1 , and wherein the case comprises at least one face that claim 1 , when the external battery is connected to the housing claim 1 , forms at least one external face of the housing.4. The kit of claim 1 , wherein the external battery comprises a case within which one or more battery cells are arranged claim 1 , and wherein the case comprises a first face and a second face connected to and approximately perpendicular to the first face claim 1 , and wherein claim 1 , when the external battery is connected to the housing claim 1 , the first and second faces of the case form at least a portion of first and second external faces of the housing.5. The kit of claim 1 , wherein the external battery comprises a 4S2P battery comprising four battery cells in series and two battery ...

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Номер записи: 95
29-08-2013 дата публикации

Portable medical apparatus for cardiopulmonary aid to patients

Номер: US20130226064A1
Автор: Corrado Bellini, Daniele Galavotti
Принадлежит: Rand Srl

A portable medical apparatus ( 1 ) for cardiopulmonary aid to patients (P) comprises: an extracorporeal circuit ( 500 ) for circulating the blood of a patient (P), which in turn comprises a line ( 200 ) for drawing venous blood from a patient (P) and a line ( 300 ) for returning arterial blood to said patient (P); at least one filtering arrangement ( 5, 6 ) placed on said extracorporeal circuit ( 500 ); a pumping unit ( 10 ) for pumping blood along the extracorporeal circuit ( 500 ); a heat exchanger ( 100 ) having an exchange body ( 101 ) for thermoregulating blood in said extracorporeal circuit ( 500 ); an oxygenator unit ( 111 ) for blood oxygenation; said medical apparatus comprising a transportable machine body ( 2 ) in which at least one seat ( 21 ) is formed for removable coupling with said exchange body ( 101 ).

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Номер записи: 96
05-09-2013 дата публикации

FILTRATION SYSTEM FOR PREPARATION OF FLUIDS FOR MEDICAL APPLICATIONS

Номер: US20130228505A1
Автор: Brugger James M., Burbank Jeffrey H.
Принадлежит: NXSTAGE MEDICAL, INC.

Systems, methods, and devices for preparation of purified water and medicaments for various uses including blood treatment are described. Methods, devices, and systems for creating multiple-treatment batches are described. For example, a medicament fluid circuit can include a container with an interior chamber. The container can have a fluid filling port and a fluid extraction port. Both ports can be connected to the interior chamber. The filling port can have two sterilizing filters, each of which has a membrane. The sterilizing filters can be connected in series the membranes are separated by a distance of at least 0.5 cm. A first of the sterilizing filters can have a sealed inlet. The fluid extraction port can be sealed. 118-. (canceled)19. A medicament fluid circuit , comprising:a container with an interior chamber;the container having a fluid filling port and a fluid extraction port, both connected to the interior chamber;the filling port having two sterilizing filters, each with a membrane, the sterilizing filters being connected in series such that their membranes are separated by a distance of at least 0.5 cm.;a first of the sterilizing filters having a sealed inlet;the fluid extraction port being sealed.20. The fluid circuit of claim 19 , where the fluid extraction port includes a line and the fluid extraction port line has a pyrogen filter connected thereto to filter contents passing through the fluid extraction port line.21. The fluid circuit of claim 19 , wherein the filling port has a filling line with a clamp pre-attached to it.22. A medicament fluid circuit claim 19 , comprising:a container with an interior chamber;the container having a fluid filling port, a fluid extraction port, and a pre-fill port all connected to the interior chamber;the pre-fill port having an inline ultrafilter;the fluid extraction port and the fluid filling ports being sealed by removable seals.23. The fluid circuit of claim 22 , wherein the container is a flexible bag capable ...

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Номер записи: 97
05-09-2013 дата публикации

DYNAMIC WEIGHT BALANCING OF FLOW IN KIDNEY FAILURE TREATMENT SYSTEMS

Номер: US20130228517A1
Автор: Hogard Michael E., Kelly Thomas D., Roger Rodolfo G.
Принадлежит:

A kidney failure treatment system includes: (i) a dialysate supply; (ii) a weighing device; a control container coupled operably to the weighing device; (iii) a diffusion membrane; (iv) a drain; first and second pumps; (v) a first fluid conduit coupled fluidly to the dialysate supply and the diffusion membrane, the first fluid conduit coupled operably to the first pump; (vi) a second fluid conduit coupled fluidly to the control container and the drain, the second fluid conduit coupled operably to the first pump; and (vii) a third fluid conduit coupled fluidly to the diffusion membrane and the control conduit, the third fluid conduit coupled operably to the second pump. 1. A kidney failure treatment system comprising:a dialysate supply;a weighing device;a control container coupled operably to the weighing device;a membrane filter;a drain;a pump;a first fluid conduit coupled fluidly to the dialysate supply and the membrane filter, the first conduit coupled operably to the pump;a second fluid conduit coupled fluidly to the control container and the drain, the second conduit coupled operably to the pump; anda bypass conduit coupled fluidly to the first fluid conduit and the control container, the bypass conduit configured to enable a difference between dialysate flow through the first fluid conduit and dialysate flow through the second fluid conduit to be sensed.2. The kidney failure treatment system of claim 1 , which includes a third fluid conduit coupled fluidly to the membrane filter and the control conduit claim 1 , the pump being a first pump claim 1 , and the third fluid conduit coupled operably to a second pump.3. The kidney failure treatment system of claim 2 , wherein the bypass conduit is coupled fluidly to the first fluid conduit and the third fluid conduit.4. The kidney failure treatment system of claim 2 , wherein at least one of the first pump and the second pump is of a type selected from the group consisting of:a peristaltic pump and a membrane pump.5. ...

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Номер записи: 98
05-09-2013 дата публикации

MANUFACTURING METHOD FOR MEDICAL EQUIPMENT FOR REDUCING PLATELET ADHESION ON A SURFACE IN CONTACT WITH BLOOD

Номер: US20130230422A1
Автор: MORI Takehisa, OKAWA Atsushi, Tsubouchi Takeshi, Uemura Kensuke
Принадлежит:

A manufacturing method for medical equipment involves electron beam irradiating a titanium or titanium alloy substrate surface that has at least been machined, whereby platelet adhesion of the surface to be contacted by blood is reduced. The manufacturing method for medical equipment can also use a specific pre-processing method and an electron beam irradiation method to reduce the platelet adhesion of the surface which is to be contacted with blood, to suppress the formation of minute depressions (craters) in the surface, which can occur due to the irradiation by an electron beam. 1. A method of manufacturing a medical device possessing a medical device configuration and configured to contact blood , the method comprising:cutting the medical device from a base material so that the medical device possesses a medical device configuration, the base material being either titanium or titanium alloy, the medical device produced by the cutting possessing an outer surface, and the cutting of the base material reducing a size of crystal grains of the titanium or titanium alloy;subjecting the medical device produced by cutting the base material to heat-treatment to thermally expand the crystal grains of the titanium or titanium alloy that were reduced in size by the cutting; andsubjecting the outer surface of the medical device which was subjected to the heat-treatment to electron beam irradiation to reduce platelet adhesion to the outer surface of the medical device when the outer surface of the medical device contacts the blood.2. The method of manufacturing the medical device according to claim 1 , wherein the subjecting of the outer surface of the medical device to electron beam irradiation comprises subjecting the outer surface of the medical device to a first electron beam irradiation using a first voltage and then subjecting the outer surface of the medical device to a second electron beam irradiation using a second voltage that is higher than the first voltage.3. The ...

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Номер записи: 99
05-09-2013 дата публикации

COAXIAL BALLOON DELIVERY DEVICE AND METHOD OF DELIVERING A TRANSSEPTAL CANNULA TO A HEART

Номер: US20130231521A1
Автор: Farnan Robert C.
Принадлежит: CIRCULITE, INC.

A transseptal cannula having a flexible cannula body, a left atrial anchor coupled to the distal end of the flexible cannula body, and a right atrial anchor operable to be attached to the left atrial anchor in vivo. The left and right atrial anchors are implanted and deployed separately. Delivery of the transseptal cannula to a heart tissue can include a low profile coaxial balloon catheter comprising a tube body including an inner member and an outer member surrounding the inner member and thereby creating an inflation channel between the inner and outer members, a hub coupled to the proximal portion of the tube body and including a fluid space in fluid communication with the inflation channel; and a balloon coupled to the distal portion of the tube body, wherein the balloon is in fluid communication with the inflation channel. The hub of the coaxial balloon catheter is constructed with a low profile so that other surgical devices can be directed over the coaxial hub without deflating and removing the balloon. 1. A coaxial balloon catheter comprising:a tube body including an inner member and an outer member surrounding the inner member and thereby creating an inflation channel between the inner and outer members;a coaxial hub coupled to a proximal portion of the tube body and including a fluid space in fluid communication with the inflation channel, the coaxial hub having a low profile so that a surgical device can be loaded over the coaxial hub; anda balloon coupled to a distal portion of the tube body, wherein a distal portion of the inner member extends through the balloon thereby creating an annular cavity between a wall of the balloon and the inner member.2. The coaxial balloon catheter of claim 1 , wherein the inner member within the balloon further includes a radiopaque marker.3. The coaxial balloon catheter of claim 1 , wherein the balloon further includes a distal cone structure operable to dilate an opening within a heart tissue.4. The coaxial balloon ...

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Номер записи: 100