УСТРОЙСТВО ДЛЯ ВЫРАБОТКИ СВЕРХЧИСТОЙ ВОДЫ

Изобретение относится к устройству для очистки воды по принципу обратного осмоса. Устройство для выработки сверхчистой воды по принципу обратного осмоса содержит фильтр обратного осмоса, который мембраной обратного осмоса разделен на первичную камеру и вторичную камеру, первичный контур, через который к первичной камере подводится сырая вода и из нее отводится концентрат, а также вторичный контур для подвода пермеата по меньшей мере к одному потребителю, предпочтительно аппарату для диализа. В трубопровод первичного контура встроен насос, а в трубопровод концентрата первичного контура встроен клапан со сливом. В или на первичном контуре и/или вторичном контуре расположено устройство для регистрации органических и/или неорганических отложений, соединенное с устройством обработки данных, а во вторичный контур встроен эластичный, способный расширяться буферный сосуд, приспособленный для выполнения обратной промывки мембраны пермеатом. Устройство для регистрации органических и/или неорганических ...

МЕДИЦИНСКАЯ ЖИДКОСТЬ ДЛЯ КОНСЕРВАТИВНОГО ЛЕЧЕНИЯ (ВАРИАНТЫ), СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ДИАЛИЗНОЕ УСТРОЙСТВО (ВАРИАНТЫ)

Может быть использовано в медицине при консервативном лечении. Сущность изобретения заключается в том, что предлагается жидкость для консервативного лечения, которая может уничтожать супероксидный анион-радикал (САР), являющийся побудителем различных заболеваний. Сырую воду, которая содержит по меньшей мере ионы натрия, калия, магния и кальция, подают в катодную камеру и анодную камеру. Для того чтобы осуществить электролиз сырой воды, в течение 0,5 - 5 с через катодный электрод и анодный электрод пропускают ток в диапазоне от 0,16 до ~ 3,2 мА/см2 в расчете на два электрода и одну диафрагму. По этому способу получают воду для консервативного лечения, которая имеет величину окислительно-восстановительного потенциала (в диапазоне) не менее -150 мВ при измерении с использованием платинового электрода. Вода для консервативного лечения может удалять из крови пациента САР, который становится причиной различных заболеваний. 3 с. и 14 з.п. ф-лы, 8 ил., 3 табл.

СПОСОБ ВВОДА РАБОЧИХ КОМАНД В АППАРАТ "ИСКУССТВЕННАЯ ПОЧКА", УСТРОЙСТВО ДЛЯ ВЫПОЛНЕНИЯ ГЕНОДИАЛИЗА

Предложены способы ввода рабочих команд в схему гемодиализа, включающую фильтр для диализа и возможность работы в соответствии с изменяемым по времени параметром, таким, как меняющаяся ультрафильтрация. Согласно этим способам, вводятся значение требуемого периода времени, заданное суммарное значение параметра, такого, как заданный объем ультрафильтрации, и предполагаемый изменяющийся по времени профиль параметра, представляющий собой ряд координат на участке, ограниченном осью ординат, на которой откладываются значения параметра, и осью абсцисс, на которой откладывается время, а график показывает профиль нарастания значения параметра. Если суммарное значение по профилю не равно заданному суммарному значению, изменяется положение предполагаемого изменяющегося по времени профиля относительно оси ординат, чтобы уравнять эти суммарные значения. После этого схема работает согласно измененному профилю, чтобы достичь заданного введенного суммарного значения в течение заданного периода времени.

КОМПЕНСАТОР С ИЗМЕНЯЕМЫМ ОБЪЕМОМ ДЛЯ ОЧИСТКИ КРОВИ

... 1. Компенсатор с изменяемым объемом для очистки крови, содержащий держатель, полость и мембраны, при этом полость (2) установлена на держателе (1), отличающийся тем, что:первая мембрана (3) и вторая мембрана (4) установлены во внутреннем пространстве указанной полости (2) на определенном интервале друг от друга, при этом внутреннее пространство полости (2) разделено на три полости, на первую полость (5), вторую полость (6) и на полость (7) для силиконового масла посредством первой мембраны (3) и второй мембраны (4), при этом полость (7) для силиконового масла расположена между первой мембраной (3) и второй мембраной (4) и сообщается с поршневым насосом (9), причем проводящие сквозные отверстия (2с) выполнены в стенке полости указанной первой полости (5) и соединяются с входными соединениями первого трехходового электромагнитного клапана (10), причем, проводящие сквозные отверстия (2d) также выполнены в стенке полости указанной второй полости (6) и соединяются с входными соединениями первого ...

УСТРОЙСТВО ДЛЯ ВЫРАБОТКИ СВЕРХЧИСТОЙ ВОДЫ

... 1. Устройство для выработки сверхчистой воды по принципу обратного осмоса с фильтром обратного осмоса, который мембраной обратного осмоса разделен на первичную камеру и вторичную камеру, с первичный контуром, через который к первичной камере подводится сырая вода и из нее отводится концентрат, а также вторичным контуром для подвода пермеата по меньшей мере к одному потребителю, предпочтительно аппарату для диализа,отличающееся тем, чтов или на первичном контуре (1, 4, 5, 9, 17, 18) и/или вторичном контуре (8, 15, 16) расположено устройство для регистрации органических и/или неорганических отложений, которое соединено с устройством обработки данных.2. Устройство по п.1, отличающееся тем, что устройство обработки данных соединено с устройством индикации измеряемых значений.3. Устройство по п.1, отличающееся тем, что устройство обработки данных при достижении или превышении предварительно заданного граничного измеряемого значения выдает предупредительный сигнал.4. Устройство по п.1, отличающееся ...

Kartusche eines medizinischen Gerätes, insbesondere eines Dialysegerätes

Verpackungseinheit für Rohstoffe für ein Dialysekonzentrat

Verpackungseinheit für verschiedene Rohstoffe, die für ein Dialysekonzentrat benötigt werden, umfassend einen Behälter (1) für einen flüssigen Anteil der Rohstoffe und wenigstens einen weiteren Behälter (2) für die übrigen Rohstoffe in trockener Form, wobei diese Behälter (1, 2) in einem Aufnahmebehälter (4) zusammengefasst sind.

COMPUTER-CONTROLLED MEDICAL CARE SYSTEM

Anlage zur zentralen Proportionierung einer Dialysierflüssigkeitsmischung

Die Erfindung betrifft eine Anlage zur extrakorporalen Blutbehandlung, die eine Steuereinheit, mehrere Blutbehandlungsvorrichtungen mit jeweils einem Blutbehandlungskreislauf und mehrere Leitungen zum Führen von Fluiden aufweist und die dazu vorgesehen und angepasst ist, zumindest einen Teil von Dialysierflüssigkeitskomponenten, aus denen die in den Blutbehandlungsvorrichtungen vorgesehenen Dialysierflüssigkeiten anmischbar sind, und Betriebsmitteln zum Desinfizieren und/oder Entkalken zentral bereitzustellen, dadurch gekennzeichnet, dass die Anlage eine zentrale Mischeinrichtung zum Anmischen der Dialysierflüssigkeiten aus den zumindest teilweise zentral bereitgestellten Dialysierflüssigkeitskomponenten und/oder den Desinfektions- und/oder Entkalkungslösungen aufweist, die dazu vorgesehen und angepasst ist, an die mehreren Blutbehandlungsvorrichtungen anschließbar zu sein und die Blutbehandlungsvorrichtungen seriell mit individuell angemischter Dialysierflüssigkeit zu versorgen, und die ...

Einrichtung zur Vorbereitung medizinischer Lösungen.

Integriertes Wassertestsystem und Verfahren für einen Nachweis von ultrageringem Gesamtchlor

Es werden ein System und Verfahren zum Bestimmen einer Konzentration von Gesamtchlor in Dialysewasser bereitgestellt. Das System umfasst ein Haupteinheitsgehäuse, eine Jodid/Wasserprobekammer und eine Reduktionsmittelkammer. Ein Elektrodenpaar überbrückt die zwei Kammern und erzeugt Tri-Jodid proportional zur Menge an Gesamtchlor im Dialysewasser. Das Elektrodenpaar weist die Menge an erzeugtem Tri-Jodid anteilig zur Menge an aktivem Chlorid im Dialysewasser nach. Das System ist zur Verwendung in Verbindung mit oder zur Eingliederung in ein Wasserreinigungssystem zum Erzeugen von Dialysefluid geeignet und kann eine Anzeige enthalten, die den Anwender darauf hinweist, eine Hämodialysebehandlung zu stoppen oder zu verhindern, wenn der Gesamtchlorpegel einen vorbestimmten Pegel überschreitet.

Trennverfahren und Trennmittel.

Vorrichtung zur endotoxinfreien Blutreinigung durch Dialyse

Kartusche zur Herstellung einer Natriumcarbonat-Lösung

VERFAHREN ZUM HERSTELLEN EINES GEMISCHES UND EINRICHTUNG ZUR DURCHFUEHRUNG DES VERFAHRENS

Distribution unit for the permeate from a reverse osmosis membrane, for the supply of purest water to a dialysis apparatus, has a secondary ring channel at the primary channel, to prevent contamination

The supply system for the delivery of the purest water to a dialysis apparatus, together with a reverse osmosis unit, has at least one secondary ring channel with its upstream section (5) concentric within the primary channel (1) to distribute the permeate from the reverse osmosis membrane. The secondary ring channel has a connection section outside the primary channel, and its downstream end (8) opens into the primary channel. The upstream section of the secondary ring channel is a straight section, from the curve (4) of the primary channel between its two straight and parallel sections (3), which can contain a throttle (10).

ERFAHREN ZUM AKTIVIEREN DER SICHERHEITSEINRICHTUNG

Vorrichtung zur Herstellung von Lösungen für medizinischen Gebrauch

Mehrkammercontainer zur Herstellung medizinischer Lösungen

Gegenstand der vorliegenden Erfindung ist ein Mehrkammercontainer und ein Verfahren zur Herstellung von medizinischen Flüssigkeiten, die aus Konzentraten zusammengesetzt werden, die einen Beitrag zur elektrischen Leitfähigkeit der Lösung liefern und weiter aus Konzentraten hergestellt werden, die keinen Beitrag zur elektrischen Leitfähigkeit der Lösung liefern. Der erfindungsgemäße Mehrkammercontainer ist durch eine Aufteilung der Lösungskomponenten in mehrere Kammern gekennzeichnet, die so konstruiert sind, dass im Zuge des Lösens durch Aufbrechen der ersten Kammerbegrenzung einer Lösungskomponente, die einen Beitrag zur elektrischen Leitfähigkeit der medizinischen Lösung beiträgt, eine weitere Kammerbegrenzung einer weiteren Lösungskomponente, die keinen Beitrag zur elektrischen Leitfähigkeit der Lösung beiträgt aufgebrochen wird.

Verfahren und Vorrichtung sowie Konnektor und Konzentratbehältereinheit zur Zubereitung von Lösungen

Die vorliegende Erfindung betrifft ein Verfahren zur Zubereitung von aus wenigstens zwei Konzentraten und einem Lösungsmittel herzustellenden Lösungen. Eine zuverlässige Lösungsherstellung wird dadurch erreicht, daß nach dem Einlegen von Konzentratbehältnissen in zugehörige Aufnahmen die Verbindung eines ersten Konzentratbehältnisses mit einer Lösungsmittelquelle erfolgt, das erste Konzentratbehältnis vom Lösungsmittel durchströmt und die Lösung in ein Sammelbehältnis geführt wird und nach dem Ausspülen des Konzentrats aus dem ersten Konzentratbehältnis eine automatische Konnektierung eines zweiten Konzentratbehältnisses erfolgt, woraufhin das zweite Konzentratbehältnis vom Lösungsmittel durchströmt und die Lösung ebenfalls dem Sammelbehältnis zugeführt wird. DOLLAR A Die vorliegende Erfindung betrifft ferner eine Vorrichtung zur Zubereitung von aus wenigstens zwei Konzentraten und einem Lösungsmittel herzustellenden Lösungen sowie einen Konnektor und eine Konzentratbehältereinheit zum ...

Total chlorine water detection system and method for medical fluid treatments

A renal therapy system is described. The system comprises: a water treatment machine 50 producing an at least partially purified water sample; a dialysis machine 100 for providing dialysis therapy to a patient, the dialysis machine receiving the water sample from the water treatment machine; and a chlorine detection component 10 configured to determine an amount of total chlorine in the water sample by (i) generating tri-iodide from the water sample by application of a voltage thereto, and (ii) monitoring a current associated with the amount of tri­-iodide. First and second chambers 24, 26 may be in contact with an iodide reservoir 12 and a reducing agent reservoir 14 respectively. A first electrode pair 42a, 42b may be in electrical contact with both the first and second chamber, and a second electrode pair 32a, 32b may be in contact with the first chamber only.

Water treatment systems,devices and methods for fluid preparation

HEMODIALYSIS APPARATUS

Method and apparatus for the production of dialysate

A method and apparatus for the production of a prescribed charge of dialysate is disclosed. With the present invention it is possible to easily and safely produce a dialysate meeting the requirements for the particular condition or illness of each patient. A metered quantity of water is supplied tangentially (6) to a mixing chamber (5) having a filter (9) associated with its outlet (8), and dissolves therein a charge of dialysate precursor powder added via a filling opening (7). Means (10)-(13) may be provided to add liquid components to the mixing chamber. ...

Modular home dialysis system - debubblers

An apparatus for removing air bubbles from blood is disclosed. The debubbler comprises front and rear covers (1002, 1008 respectively) with a fluid circuit board (1004) arranged between the two covers. A blood chamber is defined between cover (1002) and circuit board (1004) and an air chamber is defined between covers (1008) and circuit board (1004). A microporous membrane (1006) separates the blood and air chambers. A support means (1024) supports membrane (1006) from the air side of the membrane. A blood pressure sensor is provided between covers (1002, 1008). The debubbler has a blood inlet port (1022) and a blood outlet port (1020) for conducting blood to and from the blood chamber. An air port (1012) is provided in communication with the air chamber, to allow air passing through membrane (1006) to escape.

METHOD AND APPARATUS FOR PREPARING FLUIDS OF ACCURATELY PROPORTIONED COMPONENTS

Integrated water testing system and method for ultra-low total chlorine detection

Portable dialysis system

A dialysis system 10 comprising a dialysis machine 20 and a ater purification system 30. The water purification system 30 comprising a pre-treatment system 40 and a primary treatment system 80. The water purification system 30 is provided within a portable unit 90 defining an enclosure. The dialysis machine 20 is removably provided on an upper surface of the enclosure of the portable unit 90. The pre-treatment system may be arranged on a removable panel and may comprise a fluid path including a particulate filter and a primary and secondary carbon filter. The primary treatment system may be a reverse osmosis machine or a deionisation system. The water purification system may also comprise an endotoxin retentive filter and an ultraviolet light system. A method of forming this dialysis system is also provided.

Modular home dialysis system

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PRODUCTION FROM DIALYSIS CONCENTRATE FROM A HIGHLY COMPRESSED CONCENTRATE PRELIMINARY STAGE AND DEVICE TO APPLICATION AT THE DIALYSIS PLACE.

BLOOD CLEANING SYSTEM

MORE BICARBONATBEHALTER WITH TWO-CHANNEL PLUG CONNECTOR TO A MARK USE IN HAMODIALYSEGERATEN

FILTER FOR A CARTOUCHE FOR MEDICAL DIALYSIS

HOSE CLIP FOR MEDICAL APPLICATIONS

IONISCH IMPROVING DIALYSIS/CFILTRATION SYSTEM

PROCEDURE AND DEVICE FOR THE SIMULTANEOUS EXAMINATION OF A MULTIPLICITY OF DIFFERENZIELLEN PRINTING MEASURING SENSORS

MORE BEH�LTER WITH COMPONENTS OF THE SOUR CONCENTRATE F�R ONE AND PROCEDURE FOR THE PRODUCTION OF SOUR DIALYSIS CONCENTRATE DIALYSIERFL�SSIGKEIT

SYSTEM FOR THE PERITONEALDIALYSE

DIALYSAT PRODUCTION SYSTEM WITH PILLS

CARTOUCHE OF A MEDICAL INSTRUMENT, IN PARTICULAR DIALYSIS EQUIPMENT

PROMOTIONAL SYSTEM FOR HAEMODIALYSEFLUESSIGKEIT.

CONNECTING PIECE, CONTAINER WITH SUCH CONNECTING PIECE AND LIQUID PREPARATION DEVICE WITH SUITABLE CONNECTING PIECE FOR SUCH A CONTAINER

SYSTEM AND METHOD FOR THE MONITORING OF A STEERING METERING PUMP IN DIALYSIS EQUIPMENT

DIALYSIS MACHINE

DEVICE AND PROCEDURE FOR THE PREPARATION OF A TREATMENT LIQUID BY FILTRATION

SYSTEM AND PROCEDURE FOR MANUFACTURING STERILE, MIXED SOLUTIONS FOR THE AUTOMATIC PERITONEALDIALYSE

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

PROCEDURE AND DEVICE FOR THE PRODUCTION A STERILIEN OF AN INFUSION FLUID

Apparatus and method for generating dialysate for dialysis

The invention relates to an apparatus for generating dialysate for dialysis comprising a dialysate outlet (7) and a dialysate inlet (6) and dialysate purifying means, wherein the purifying means comprise a cryopurifier for generating pure water, wherein the inlet (101) of the cryopurifier is connected to the dialysate outlet (7) and the outlet (125) of the cryopurifier is connected to the dialysate inlet (6). The invention also relates to a method for reclaiming of fresh dialysate from ultrafiltrate and wasted dialysate extracted from a dialysis patient, comprising the following steps: (a) preparing an ice slurry from the dialysate, wherein the ice slurry contains ice crystals and a liquid containing solutes; and (b) separating the ice crystals from the liquid containing the solutes.

Device and method for producing a peritoneal dialysis solution

The invention relates to a device for producing a peritoneal dialysis solution at the place of use comprising a disposable with a solution bag and filling lines and patient lines connected thereto, a provision unit for liquid, said provision unit being connected to the filling line, a control unit and actuators for regulating a flow from the provision unit to the disposable, wherein the device further comprises a scale on which the solution bag of the disposable is arranged, and wherein the control unit is designed to cause, by means of the actuators, the provision unit to fill the solution bag with liquid and to determine, by means of the scale, the amount of fluid that has flowed into the solution bag.

CONTROL OF A WATER DEVICE VIA A DIALYSIS MACHINE USER INTERFACE

A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.

Virtual kidney donation

A system includes a dialyzer having a blood side and a dialysate side, a first extracorporeal circuit including one or more first fluid connectors for connecting the blood side of the dialyzer to the vascular system of a kidney patient, a second extracorporeal circuit including one or more second fluid connectors for connecting the dialysate side of the dialyzer to the vascular system of a healthy animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, where the driver is configured to drive the first pump using energy from an energy source.

Container filled with a liquid concentrate for making dialysate

Sensor apparatus systems, devices and methods

Methods of regional citrate anticoagulation dialysis

A method of performing regional citrate anticoagulant dialysis of a patient's blood includes flowing blood from and back to the patient through an extracorporeal circuit including a dialyzer having semi-pelmeable dialysis membranes and a dialysate chamber surrounding the membranes. The method further includes flowing a dialysate containing calcium and citrate through the dialysate chamber of the dialyzer and introducing citrate into the patient's blood upstream of the dialyzer, whereby the patient's blood is dialyzed. The method can further include predicting the concentration of systemic ionized calcium in the blood of the patient at any point in the dialysis treatment or post-dialysis, such as by a mathematical model. The method can further include statistically correcting the preliminary predicted postdialysis concentration of systemic ionized calcium in the patient's blood to provide a final predicted post-dialysis systemic ionized calcium concentration.

Method and apparatus for priming an extracorporeal blood circuit.

A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.

Container containing at least two solid materials, and use thereof

Device and method for detecting recirculation during an extracorporeal blood treatment

The invention relates to a device and a method for detecting recirculation for an extracorporeal blood treatment device, and to an extracorporeal blood treatment device having a device for detecting recirculation. The device according to the invention and the method according to the invention are based on a targeted haemodilution by administering a bolus of a substitution fluid (substituate), which leads to a change in the pressure conditions in the venous and arterial branches (6, 7) of the extracorporeal circuit as a result of a change in the viscosity of the fluid flowing in the extracorporeal blood circuit (5A). Recirculation is determined by detecting the pressure change in the extracorporeal circuit. The device for detecting recirculation has a control unit (17), which cooperates with the blood conveying device (8) in the blood treatment device and with the substituate conveying device (16) in the blood treatment device. The control unit (17) provides an operating mode for detecting ...

MULTI-CONTAINER SYSTEMS AND USES THEREOF

A multi-container system apparatus comprising at least two independent containers, each container of said at least two containers for containing at least one component of the final formulation of a medium; a connector; a connecting tubing line connected to the connector; at least two output tubing lines, the first and second output tubing lines of said at least two output tubing lines connecting the first and second containers of said at least two containers, respectively, to the connecting tubing line.

BLOOD TREATMENT SYSTEMS AND METHODS

A dialysis system, comprising: a chamber including a membrane that is movable in the chamber and that fluidly separates a first portion of the chamber from a second portion of the chamber, the chamber including a first inlet to the first portion and a second inlet to the second portion; and a blood leak sensor associated with the chamber and arranged to detect blood in the first portion of the chamber, wherein the blood leak sensor is arranged to measure a first level in the first portion and a second level in the second portion for comparison of the first and second levels to each other to determine whether blood is present in the first portion.

Connector for disposable container to be used in dialysis machines

PUMPING CASSETTE

PUMPING CASSETTE A fluid pumping cassette comprising a metering pump, the metering pump comprising a fluid pumping chamber separated from an actuation chamber by a flexible membrane; the actuation chamber having an actuation port for connection to a pneumatic air source to provide positive or negative pneumatic pressure to the flexible membrane; the fluid pumping chamber having a first fluid port, second fluid port, and third fluid port for directing the movement of a fluid; a first fluid valve being interposed between the first fluid port and a first fluid path in the cassette; a second fluid valve being interposed between the second fluid port and a second fluid path in the cassette; and a third fluid valve being interposed between the third fluid port and a third fluid path in the cassette, wherein the metering pump is configured to pump a first fluid from the first fluid path to the second fluid path by operation of the first, second and third valves in a first mode; and the metering ...

Container

The present invention relates to a combination of a container comprising a connecting portion and of a fluid preparation device, in particular a dialysis machine, which fluid preparation device is suitable for mounting and connecting the connecting portion of the container, wherein the fluid preparation device comprises at least one line which is in fluid communication with the interior of the container at least in the connected position of the container, the container being filled with a first medium, wherein the combination and preferably container comprises a reservoir containing a second medium, wherein the fluid preparation device comprises means for opening the reservoir so that the first and second medium are mixed with each other.

System for fluid delivery in a dialysis clinic

A SYSTEM FOR PREPARING A FLUID INTENDED FOR A MEDICAL PROCEDURE BY MIXING AT LEAST ONE CONCENTRATE IN POWDER FORM WITH WATER AND A CARTRIDGE INTENDED TO BE USED IN SAID SYSTEM

DIALYSATE PREPARATION APPARATUS

MULTIPLE COMPARTMENT BAG ASSEMBLY FOR DIALYSIS FLUID

The invention concerns a multiple compartment flexible bag assembly including a first predetermined volume of an aqueous sodium bicarbonate component solution contained in at least one of the multiple compartments and a second predetermined volume of an aqueous acid component solution contained in at least another of the multiple compartments, the component solutions being intended to be mixed together to obtain a peritoneal dialysis, hemodialysis or replacement fluid, characterized in that the aqueous acid component solution comprises an amount of dissolved carbon dioxide. The partial pressure value of carbon dioxide exhibited the aqueous acid component solution is preferably matched with the partial pressure value of carbon dioxide determined for the aqueous sodium bicarbonate component solution.

BIOMETRIC MEMBRANES AND USES THEREOF

A liquid membrane system is disclosed in the form of a biochannel containing bulk liquid membrane (BLM), biochannel containing emulsion liquid membrane (ELM), and biochannel containing supported (immobilised) liquid membrane (SLM), or a combination thereof, wherein said liquid membrane system is based on vesicles formed from amphiphilic compounds such as lipids forming a bilayer wherein biochannels have been incorporated and wherein said vesicles further contain a stabilising oil phase. The uses of the membrane system include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water.

CONNECTOR FOR DISPOSABLE CONTAINER TO BE USED IN DIALYSIS MACHINES

The present invention relates to a connector for a replaceable container to be used in a medical machine, which is comprised by at least a body, the inner side of which is traversed by inlet and outlet tubes extending from within such container towards an outer side of the connector, wherein said tubes separately extend leading to two laterally spaced-apart apertures that are removably attachable to a mounting means and supplementary connection of said machine.

HEMODIALYSIS PROCESSES AND HEMODIALYSIS SOLUTIONS

Techniques for predicting the respective concentrations and distributions of diffusible materials in solutions on opposing sides of a semi permeable membrane are provided. Unique compositions for hemodialysis using the mathematical relationships involved are provided. Also processes are provided for controlling the rate of change in concentration of a diffusible material in and fluid into another fluid on an opposing side of semi-permeable membrane are provided. Apparatus for practicing such processes are described.

DOUBLE-ACTION PROPORTIONING PUMP

DOUBLE-ACTION PROPORTIONING PUMP In a blood dialysis system a proportioning pump accurately mixes precise quantities of water and concentrate. A double-acting piston assembly is disposed in a stepped cylinder which has proximity sensing switches at both ends thereof. These are operated as the piston assembly reaches the end of its stroke in each direction. The switches alternate a bistable solenoid valve system which directs pressurized water to opposite sides of a large central piston, thus causing the piston assembly to reciprocate. Small pistons, attached on opposite sides of the large piston, move in small pump chambers, with check valves. The small pistons pump concentrate in a precise ratio to the volume of water driving the large piston.

DIALYSIS PROCESS AND APPARATUS FOR ISOLATION OF THERAPEUTICALLY ACTIVE SUBSTANCES

METHOD OF MAKING STERILE, NON-PYROGENIC, SOLUTIONS

Preparing a non-pyrogenic solution by moving solutes into distilled water through a membrane from a zone of lower hydrostatic pressure to a zone of higher hydrostatic pressure.

APPARATUS FOR THE AUTOMATIC PREPARATION OF A SOLUTION OF CONTROLLED CONCENTRATION

PROPORTIONING DIALYSIS MACHINE FOR COIL AND PARALLEL- FLOW DIALYZERS

INTRADIALYTIC USE OF SODIUM NITRITE

Provided herein are methods for maintaining physiological levels of nitrite in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium nitrite to a subject undergoing hemodialysis.

METHODS AND SYSTEMS FOR MEASURING AND HEATING DIALYSATE

The present specification provides a dialysate management system for generating, weighing, and heating a dialysate fluid during a dialysis treatment. The dialysate management system includes a container and base enclosure. A bottom surface of the container rests within the base enclosure, which is configured to weigh the fluid in the container and measure its conductivity. The fluid may be heated using a heater integrated into the base enclosure or positioned in-line with a fluid pathway. The base of the container is preferably sloped and positioned within the internal volume of the container is a disposable prescription bag having a predefined quantity of prescription compositions that dissolve when water is poured into the container.

SYSTEM AND METHOD FOR PERFORMING ALTERNATIVE AND SEQUENTIAL BLOOD AND PERITONEAL DIALYSIS MODALITIES

A dialysis system comprises a dialysis fluid pump, a dialysis fluid line, a blood filter in fluid communication with the dialysis fluid pump via the dialysis fluid line, an extracorporeal circuit connectable to a patient, a blood pump in fluid communication with the blood filter via the extracorporeal circuit, and a control unit programmed to (i) in a first treatment, prepare peritoneal dialysis treatment fluid by combining purified water with a peritoneal dialysis concentrate using the dialysis fluid pump and the dialysis fluid line, and (ii) in a second treatment, prepare hemodialysis treatment fluid by combining purified water with a blood treatment concentrate using the dialysis fluid pump and the dialysis fluid line.

SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION USING WATER ACCUMULATOR AND DISPOSABLE SET

A peritoneal dialysis system includes a water purifier, a cycler, and a disposable set operable with the cycler. The disposable set includes a pumping cassette including a water inlet port, a heater/mixing container in fluid communication with the pumping cassette, a water accumulator, a first water line segment, and a second water line segment. The first water line segment is in fluid communication with the water inlet port and the water accumulator. Additionally, the second water line segment is in fluid communication with the water accumulator and the water purifier.

A SYSTEM AND A METHOD FOR PRODUCING MICROBIOLOGICALLY CONTROLLED FLUID

A method and a system (10a) comprising an integrated water purifying apparatus (110) with a pre-filter circuit (402) including a particle filter and an activated carbon filter arranged to produce pre-treated water; a fluid circuit (404) arranged to receive pre-treated water from the pre-filter circuit (402), the fluid circuit (404) includes an RO-pump (450) and a Reverse Osmosis, RO, device, (301) arranged to produce purified water; a heating device (302) arranged to heat purified water from the RO device (301) to a temperature above 65 °C; the water purifying apparatus (110) is further arranged to heat disinfect the fluid circuit (404) using the heated purified water. The system (1) further comprises a line set (40) connected to the purified water outlet connector (128) at a water line connector (68) of the line set (40), wherein the line set (40) includes at least one sterile sterilizing grade filter (70a, 70b) arranged to filter the purified water into sterile purified water.

MULTI-CONTAINER SYSTEMS AND USES THEREOF

A multi-container system apparatus comprising at least two independent containers, each container of said at least two containers for containing at least one component of the final formulation of a medium; a connector; a connecting tubing line connected to the connector; at least two output tubing lines, the first and second output tubing lines of said at least two output tubing lines connecting the first and second containers of said at least two containers, respectively, to the connecting tubing line.

DIALYSIS SYSTEM

A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

PREPARATION APPARATUS AND PREPARATION METHOD FOR DIALYSIS FLUID OF VARIABLE BICARBONATE ION CONCENTRATION TYPE, DIALYSATE OF VARIABLE BICARBONATE ION CONCENTRATION TYPE, AND DIALYSIS SYSTEM OF VARIABLE BICARBONATE ION CONCENTRATION TYPE

An object of the present invention is to provide a technology for preparing a dialysis fluid that is capable of flexibly changing the bicarbonate ion concentration and maintaining the concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels even during dialysis according to the disease state of a patient. In connection with a three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, suitably adjusting the amount of the agent B during dialysis fluid preparation makes it possible to maintain the concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly change the bicarbonate ion concentration therein. Moreover, in the three-component dialysate, adjusting the ratio between the amount of the agent S and the amount ...

PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL

A package has a transport/storage state for storing powdery material which is to be mixed with a solvent to form a medical solution, e.g. for use in dialysis treatment. The package comprises a compartment (6) which is at least partially defined by two opposing wall portions, and a connector (10). In the transport/storage state, the compartment contains the powdery material in the form of at least two distinct sets (2A-2D) of powdery material of different compositions, where the opposing wall portions are brought into engagement with the powdery material so as to immobilize the sets of powdery material (2A-2D). When used for preparation of the medical solution, a fluid is selectively admitted into the package via the connector (10) so as to expand the compartment (6) and enable mixing of the sets (2A-2D) of powdery material with the solvent in the compartment (6).

HEAT EXCHANGE FLUID PURIFICATION FOR DIALYSIS SYSTEM

Disclosed herein are small, lightweight, portable, systems that have the capability of reliably, reproducibly, highly efficiently and relatively inexpensively providing a source of purified water of sufficient volumes for home dialysis. In addition, the systems disclosed herein require much less purified water at any one time than the volumes typically needed for dialysis today, thereby further reducing the expense of running the system at home.

HEMODIALYSIS CONDUCTIVITY SERVO-PROPORTIONING SYSTEM

An improved conductivity based servo-proportioning sys- tem (10, 40) for hemodialysis machines. The servo-proportioning system calculates the actual conductivity contributions of the indi- vidual chemical components of the concentrate being utilized, to determine the conductivity set points. An Acidified and Bicarb operation is being performed, then the servo-proportioning sys- tem calculates a conductivity set point at both an intermediate and final stage of the servo-proportioning system. If only acetate is being performed, then only the acetate individual chemical components are calculated. If the Na and/or Bicarb concentra- tions are to be varied, then the conductivity is calculated for the changed Na and/or Bicarb concentrations.

SEPARATION METHOD AND SEPARATING AGENT

A phosphopolyol compound such as pyrogens is separated from its solution to use in the pharmaceutical field by bringing the solution into contact with a porous adsorbent which has a pore size of 1 nm to 20 microns and comprises a base material and a functional chain group of an aliphatic amine type having a chain length of 2 to 50, bonded to the base material.

Cassette system integrated apparatus

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Dialysis cassettes and related systems and methods

A method that includes conveying overheated dialysate through a cassette in a manner to reduce the temperature of the overheated dialysate, and a dialysis system including a control unit configured to cause overheated dialysate to be conveyed through a cassette in a manner to reduce the temperature of the overheated dialysate.

Multichamber container for preparing medicinal solutions

The subject matter of the present invention is a multichamber container and a method for preparing medical fluids composed of concentrates which make a contribution toward the electrical conductivity of the solution and are additionally prepared from concentrates which do not make a contribution toward the electrical conductivity of the solution. The inventive multichamber container is characterized in that it is constructed by dividing the solution components into multiple chambers, so that following the dissolving due to breaking open of the first chamber border of a solution component, which makes a contribution toward the electrical conductivity of the medicinal solution, another chamber border of another solution component which does not make any contribution toward the electrical conductivity of the solution is broken open.

Filtration system for preparation of fluids for medical applications

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment which provides multiple benefits and liabilities to overcome, as discussed herein. Mechanisms for preparing pure water for infusion or medicaments are described such as elimination of chlorine and colloidal aluminum. Also various control mechanisms to help avoid contamination are describe.

System for carrying out a blood treatment

The present invention relates to a system for the carrying out of a blood treatment, in particular a dialysis treatment, wherein the system has at least one blood treatment device, in particular a dialyzer, and at least one tank from which treatment fluid, in particular dialysis fluid, is removed during the carrying out of the blood treatment and/or into which consumed treatment fluid, in particular consumed dialysis fluid, is filled during the carrying out of the blood treatment, wherein the tank is an element of at least one mobile apparatus which can be connected to the blood treatment device such that at least one fluid connection can be established between the tank and the blood treatment device.

Cassette system integrated apparatus

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Blood treatment systems and methods

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

Pumping cassette

A pump cassette is disclosed. The pump cassette includes a housing having at least, one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

DIALYSIS APPARATUS AND METHOD FOR CONTROLLING A DIALYSIS APPARATUS

Dialysis apparatus including a blood treatment unit having a dialysate chamber and a blood chamber separated by a semipermeable membrane, a dialysate circuit presenting a supply line and a discharge line connected to the blood treatment unit, a preparation device for preparing a dialysate containing a substance present in the blood too and a regulator regulating the concentration of the substance in the dialysate. A blood circuit to circulate extracorporeal blood through the blood chamber; a controller that determines a value representative of the concentration of the substance in the blood and are programmed for driving the regulator as a function of the determined value representative of the substance concentration in the blood such that the substance concentration in the dialysate tends towards the substance concentration in the blood. 118. to . (canceled)19. A dialysis apparatus comprising:a blood treatment unit comprising a dialysate chamber and a blood chamber separated by a semipermeable membrane;a dialysate circuit comprising a supply line and a discharge line connected to said blood treatment unit, respectively, upstream and downstream of said dialysate chamber;a preparation device configured to prepare a dialysate containing a substance which is also present in blood, the preparation device includes a regulator configured to regulate a concentration of the substance in dialysate, said preparation device being connected to said supply line;a blood circuit configured to circulate extracorporeal blood through said blood chamber;a controller configured to determine a value representative of the concentration of said substance in the blood and configured to drive the regulator as a function of the determined value representative of the substance concentration in the blood such that the substance concentration in the dialysate trends towards the substance concentration in the blood.20. The apparatus according to claim 19 , wherein said substance is a ionic ...

PREPARATION APPARATUS AND PREPARATION METHOD FOR DIALYSIS FLUID OF VARIABLE BICARBONATE ION CONCENTRATION TYPE, DIALYSATE OF VARIABLE BICARBONATE ION CONCENTRATION TYPE, AND DIALYSIS SYSTEM OF VARIABLE BICARBONATE ION CONCENTRATION TYPE

Technology for preparing a dialysis fluid capable of flexibly changing bicarbonate ion concentration and maintaining concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels during dialysis according to the disease state of a patient. A three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, with suitable adjustment of the amount of the agent B during dialysis fluid preparation maintains concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly changes the bicarbonate ion concentration therein. Adjusting the ratio between the amount of the agent S and agent B when the dialysate is used also makes it possible to maintain the sodium ion concentration at a constant level or flexibly change the sodium ion concentration. 1. A dialysis fluid preparation apparatus comprising:an agent S container that accommodates an agent S containing sodium chloride and has an outlet,an agent B container that accommodates an agent B containing sodium bicarbonate and has an outlet,an agent A container that accommodates an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate and has an outlet,a mixing part in which the agent S discharged from the agent S container, the agent B discharged from the agent B container, and the agent A discharged from the agent A container are mixed to give a dialysis fluid,an input part that receives an input of dialysis fluid data containing bicarbonate concentration information that specifies a bicarbonate ion concentration in the dialysis fluid, anda control part that controls at least an amount of the agent B supplied to the mixing part based on the dialysis fluid data so as to change the bicarbonate ion concentration in the dialysis fluid, ...

CONTROL OF A WATER DEVICE VIA A DIALYSIS MACHINE USER INTERFACE

A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface. 1. A home medical device system comprising:a home therapy machine for performing a home therapy on a patient;a user interface operably connected to the home therapy machine, the user interface receiving operator inputs;a water treatment device in fluid communication with the home therapy machine; anda data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.2. The home medical device system of claim 1 , wherein the water treatment device transmits to the home therapy machine at least one of: (i) state information claim 1 , (ii) component life information claim 1 , (iii) self test results claim 1 , (iv) alert information or (v) version information.3. The home medical device system of claim 2 , wherein the user interface displays at least one of: (i) the state information claim 2 , (ii) the component life information claim 2 , (iii) the self test results claim 2 , (iv) the alert information or (v) the version information.4. The home medical device system of claim 1 , in which the home therapy machine transmits to the water treatment device at least one of: (i) state change requests claim 1 , (ii) status ...

FILTRATION SYSTEM FOR PREPARATION OF FLUIDS FOR MEDICAL APPLICATIONS

Systems, methods, and devices for preparation of purified water and medicaments for various uses including blood treatment are described. Methods, devices, and systems for creating multiple-treatment batches are described. For example, a medicament fluid circuit can include a container with an interior chamber. The container can have a fluid filling port and a fluid extraction port. Both ports can be connected to the interior chamber. The filling port can have two sterilizing filters, each of which has a membrane. The sterilizing filters can be connected in series the membranes are separated by a distance of at least 0.5 cm. A first of the sterilizing filters can have a sealed inlet. The fluid extraction port can be sealed. 118-. (canceled)19. A medicament fluid circuit , comprising:a container with an interior chamber;the container having a fluid filling port and a fluid extraction port, both connected to the interior chamber;the filling port having two sterilizing filters, each with a membrane, the sterilizing filters being connected in series such that their membranes are separated by a distance of at least 0.5 cm.;a first of the sterilizing filters having a sealed inlet;the fluid extraction port being sealed.20. The fluid circuit of claim 19 , where the fluid extraction port includes a line and the fluid extraction port line has a pyrogen filter connected thereto to filter contents passing through the fluid extraction port line.21. The fluid circuit of claim 19 , wherein the filling port has a filling line with a clamp pre-attached to it.22. A medicament fluid circuit claim 19 , comprising:a container with an interior chamber;the container having a fluid filling port, a fluid extraction port, and a pre-fill port all connected to the interior chamber;the pre-fill port having an inline ultrafilter;the fluid extraction port and the fluid filling ports being sealed by removable seals.23. The fluid circuit of claim 22 , wherein the container is a flexible bag capable ...

Producing method for living organism-applicable hydrogen-contained fluid and producing apparatus for the same

A producing method for a living organism-applicable hydrogen-contained fluid, which includes hydrogen molecules in living organism-applicable fluid enclosed in a container ( 2 i ) with hydrogen molecule permeability, is provided. This method includes a hydrogen exposing step of exposing hydrogen molecules to the container ( 2 i ) in which the living organism-applicable fluid is enclosed from the outside of the container without opening the container. The container with hydrogen molecule permeability is one that allows a dissolved hydrogen concentration of a normal saline solution to be 1 ppb or greater when the container filled with the normal saline solution is immersed for 5 hours in a volume of hydrogen water, which stably maintains an approximately saturated state (1.6 ppm at 20 C degrees under 1 barometric pressure) and is 20 times the content volume of the container.

Heating apparatus for heating dialysis liquid, dialysis liquid tube set, set, medical apparatus and methods

A heating apparatus for heating a dialysis liquid includes a receiving section for receiving a heating bag through which dialysis liquid to be heated can flow, and a sensor system for determining or monitoring the deformation or the position of the heating bag in the receiving section of the heating apparatus or both. A dialysis liquid tube set, a set, a medical apparatus and a method are also described. 1. A heating apparatus for heating a dialysis liquid , comprising:a receiving section for receiving a heating bag through which the dialysis liquid can flow for being heated; anda sensor system for determining or monitoring a deformation of the heating bag or a location of the heating bag in at least one of the heating apparatus or the receiving section of the heating apparatus.2. The heating apparatus according to claim 1 , wherein the receiving section is configured for allowing the deformation of the heating bag due to an interior pressure of the heating bag in only one extension direction of the heating bag.3. The heating apparatus according to claim 1 , wherein the heating apparatus or the receiving section comprises at least one reinforcing element which is arranged for effecting a reinforcement of the receiving section against a radially acting pressure of the heating bag.4. The heating apparatus according to claim 1 , wherein the heating apparatus is configured for enclosing the flow-through heating bag with respect to a circumferential direction of the heating bag along a whole length of the heating bag.5. The heating apparatus according to claim 1 , wherein the heating apparatus is arranged for cylindrically enclosing the flow-through heating bag.6. The heating apparatus according to claim 1 , wherein the sensor system for monitoring the deformation the heating bag comprises at least one mechanical or one optical sensor.7. The heating apparatus according to claim 1 , further comprising:an apparatus for at least one of outputting an alarm or for stopping a ...

Bag with a flexurally rigid plastic part welded into it

The subject of the invention is a bag for receiving, preparing and producing dialysis fluid. The invention relates in particular to a bag having a sealing bordering line and a flexurally rigid hard plastic part connected to the film material. The hard plastic part is connected to the film material separately from the sealing bordering line and offers an area for gripping the bag for fastening it without having to act mechanically on the sealing bordering line in a direct manner.

DIALYSIS CASSETTES AND RELATED SYSTEMS AND METHODS

A method that includes conveying overheated dialysate through a cassette in a manner to reduce the temperature of the overheated dialysate, and a dialysis system including a control unit configured to cause overheated dialysate to be conveyed through a cassette in a manner to reduce the temperature of the overheated dialysate. 1. A method of controlling the temperature of liquid in a dialysis cassette that includes a first pump chamber configured to cooperate with a first pump to pump liquid within the dialysis cassette , and a second pump chamber configured to cooperate with a second pump to pump liquid within the dialysis cassette , the method includingcooling the liquid in the dialysis cassette by pumping liquid from the first pump chamber to the second pump chamber.2. The method of claim 1 , further comprising pumping the liquid from the second pump chamber of the dialysis cassette back to the first pump chamber of the dialysis cassette.3. The method of claim 2 , wherein the liquid is pumped back and forth between the first and second pump chambers of the dialysis cassette until the liquid reaches the desired temperature.4. The method of claim 1 , further comprising turning off a heating device configured to heat the liquid in the dialysis cassette claim 1 , and closing an outlet passage formed in the cassette such that the liquid is substantially prevented from exiting the cassette via the outlet passage.5. The method of claim 4 , wherein a fluid line is connected to the outlet passage and to a patient claim 4 , and closing the outlet passage substantially prevents the liquid from being delivered via the fluid line to the patient.6. The method of claim 1 , wherein unheated liquid is present in the second pump chamber when the liquid heated to a temperature greater than the desired temperature is pumped into the second pump chamber.7. The method of claim 6 , wherein claim 6 , when a mixture of the unheated liquid and the liquid heated to a temperature greater ...

Filtration system for preparation of fluids for medical applications

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed through a first filtration step which is effective for creating purified water and a pair of ultrafilters placed at the outlet. The ultrafilters are separated by an intervening flow path to prevent grow-through from the outlet end upstream. In embodiments, a recirculation path with an air removing filter helps to eliminate air from the ultimate product water.

PRESSURE CONVERTER-PROTECTIVE DEVICE FOR BLOOD TUBING SYSTEMS

The invention relates to a protective device for a pressure converter in a blood treatment machine. Traditional converter-protective devices are not easy to mount on the treatment machine because they offer the user hardly any gripping surface. With the converter-protective device according to the present invention, the housing with the anti-contamination barrier can be gripped on the main surface in mounting it and can be inserted into the machine. This is achieved by the fact that the connector axes and the housing with the anti-contamination barrier are situated in parallel planes which are arranged perpendicular to the surface of the device after assembly. Due to this orientation, both sides of the anti-contamination barrier can be observed from the front at the sides during operation so that rupture of the anti-contamination barrier can easily be detected by the user. 1. A converter-protective device comprising a flat transparent housing consisting of a front wall and a rear wall which form the main area of the housing , at least one narrow side wall and a gas-permeable liquid barrier which divides the housing into two chambers; the converter-protective device additionally comprises a first tubular connector for connection to a blood treatment machine and a second tubular connector for connection to a blood tubing system such that a tubular connector is connected to each chamber , characterized in the tubular connector is positioned on the side wall of the flat housing , the tubular connector and the main area of the housing thereby being aligned essentially in parallel along an axis , so that the front and rear walls of the housing can be used as a gripping surface , for mounting on the blood treatment machine.2. The device according to characterized in that the housing consists of a first part and a second part claim 1 , the two parts being connected to one another in a liquid-tight manner with the gas-permeable liquid barrier being arranged between the parts ...

Blood Purification System

A blood purification system includes a plurality of monitoring devices ( 1 ) each attached to a dialyzer ( 5 ) to perform a blood purification treatment on a patient. A dialysate supplying device ( 2 ) supplies a dialysate to each of the monitoring devices ( 1 ). The plurality of monitoring devices ( 1 ) and the dialysate supplying device ( 2 ) are connected to each other by a LAN cable α. Thus, predetermined individual information relating to the plurality of monitoring devices ( 1 ) is transmitted from each of the monitoring devices ( 1 ) to the dialysate supplying device ( 2 ).

Device and Method for Detecting the Recirculation During an Extracorporeal Blood Treatment

A device and method for detecting recirculation for an extracorporeal blood treatment apparatus and an apparatus with a device for detecting recirculation are based on targeted haemodilution by administration of a substituate bolus, causing a pressure change in venous and arterial branches of the extracorporeal circuit due to a viscosity change of flowing fluid. 1. A device for detecting recirculation for an extracorporeal blood treatment apparatus , the extracorporeal blood treatment apparatus comprising an extracorporeal blood circuit with an arterial blood line , which leads to a first chamber of a dialyser or filter divided by a membrane into the first chamber and a second chamber , and a venous blood line , which leads away from the first chamber of the dialyser or filter , a fluid system , which comprises the second chamber of the dialyser or filter , a device for conveying blood at a preset blood flow rate Qthrough the arterial blood line into the first chamber of the dialyser or filter and through the venous blood line from the first chamber of the dialyser or filter , and a device for supplying substituate to the blood at a preset substituate rate Qin the arterial blood line upstream of the dialyser or filter , the device for detecting the recirculation comprising:a measuring unit adapted for measuring pressure in the extracorporeal circuit in the arterial and/or venous blood line,an evaluation unit adapted for detecting the recirculation based on the pressure measurement, and{'sub': b1', 'b2', 's, 'a control unit cooperating with the device for conveying blood and the device for supplying substituate, the control unit being adapted, in an operating mode for detecting the recirculation, to control the device for conveying blood such that in a preset time interval, a preset first blood flow rate Qis reduced to a preset second blood flow rate Q, and to control the device for supplying substituate such that in the preset time interval, substituate is fed at ...

Dialysis machine

Embodiments of the present disclosure include a dialysis system having a disposable cartridge which includes one or more flowpaths arranged on or within the cartridge.

Dialysis implant and methods of use

A device and methods for treating renal failure are disclosed. One embodiment of the device is an implantable peritoneal dialysis device. When in use, the device can have a semi-permeable reservoir implanted in the peritoneal cavity. The reservoir can receive blood waste and drain through one or more conduits, via a pump, to the biological bladder. Solids and/or a solution benefiting dialysis can be pumped to the reservoir and/or implanted in the peritoneal cavity.

PERITONEAL DIALYSIS INTRACYCLE OSMOTIC AGENT ADJUSTMENT

The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the peritoneal cavity of the patient. The method can include infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient; monitoring one or more patient parameters; and adjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using an on-line peritoneal dialysis machine. The system can include a peritoneal dialysis cycler. 1infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient;monitoring one or more patient parameters; andadjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using the on-line peritoneal dialysis machine.. A method for adjusting an osmotic agent concentration in a peritoneal cavity, comprising the steps of: This application is a Continuation of U.S. patent application Ser. No. 15/666,631 filed Aug. 2, 2017, which claims the benefit of and priority to U.S. Provisional Patent Application No. 62/373,228 filed Aug. 10, 2016, the entire disclosure of which is incorporated by reference herein.The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the ...

INTEGRATED WATER TESTING SYSTEM AND METHOD FOR ULTRA-LOW TOTAL CHLORINE DETECTION

A dialysis method and system for determining an amount of total chlorine in a partially purified water sample is disclosed. The system includes a water machine that produces at least partially purified water including an at least partially purified water sample and a dialysis machine that provides a dialysis treatment to a patient. The dialysis machine receives the at least partially purified water from the water machine to prepare dialysis fluid for the dialysis treatment. The system also includes a total chlorine detector configured to receive the at least partially purified water sample, at a first time apply a source voltage to the at least partially purified water sample, and at a second time stop applying the source voltage to the at least partially purified water sample and instead monitor a sensed electrical parameter to determine an amount of total chlorine in the at least partially purified water sample. 1. A method of determining an amount of total chlorine in a water sample for a hemodialysis treatment , the method comprising:producing, via a water purification machine, an at least partially purified water sample;receiving, in a total chlorine detector, the at least partially purified water sample from the water purification machine;applying at a first time, via the total chlorine detector, a source voltage to the at least partially purified water sample;removing at a second time, via the total chlorine detector, the source voltage to the at least partially purified water sample;measuring, after the second time, via the total chlorine detector, an electrical parameter of the at least partially purified water sample; anddetermining, via the total chlorine detector, the amount of total chlorine in the at least partially purified water sample based on the measured electrical parameter.2. The method of claim 1 , wherein the total chlorine detector is included within at least one of the water purification machine or a dialysis machine that receives at least ...

INTRADIALYTIC USE OF SODIUM THIOSULFATE

Provided herein are methods for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium thiosulfate to a subject undergoing hemodialysis. 119-. (canceled)20. A method for preventing angina , cerebral vasospasm , claudication , critical limb ischemia , peripheral vascular disease , or sickle cell crisis in a subject undergoing dialysis , comprising intradialytically contacting said subject's blood with a dialyzer membrane that is also in contact with a thiosulfate-spiked dialysate , wherein an aqueous solution comprising sodium thiosulfate is added to an unspiked dialysate as the unspiked dialysate flows from a dialysis machine to a dialyzer membrane , wherein said unspiked dialysate comprises a mixture of water , an acid concentrate solution , and a bicarbonate concentrate solution , and wherein said thiosulfate-spiked dialysate has a pH greater than about 7.0 , wherein the concentration of thiosulfate in said thiosulfate-spiked dialysate is no more than about 10 micromolar.21. The method of claim 20 , wherein the physiological level of thiosulfate in said subject is no more than about 10 micromolar.22. The method of claim 20 , wherein the physiological level of thiosulfate in said subject is between about 500 nanomolar and about 5 micromolar.23. The method of claim 20 , wherein the physiological level of thiosulfate in said subject is about 3 micromolar.24. The method of claim 20 , wherein the concentration of thiosulfate in said thiosulfate-spiked dialysate is between about 500 nanomolar and about 5 micromolar.25. The method of claim 20 , wherein the concentration of thiosulfate in said thiosulfate-spiked dialysate is about 3 micromolar.26. The method of claim 20 , wherein said aqueous solution comprising sodium thiosulfate comprises no more than about 300 mg/L of sodium thiosulfate.27. The method of claim 20 , wherein said water comprises no more ...

Blood purification apparatus

A blood purification apparatus including a line section through which working dialysate to be introduced into a blood purifier or drain liquid discharged from the blood purifier is caused to flow; a delivery unit that delivers liquid in the line section; an introduction port connected to a supply route through which undiluted dialysate or the working dialysate is supplied, the introduction port allowing the undiluted dialysate or the working dialysate in the supply route to be introduced into the apparatus; an introduction route connected to the introduction port and through which the undiluted dialysate or the working dialysate introduced from the introduction port flows into the line section; a valve unit provided to the introduction route and being capable of opening or closing the introduction route by being opened or closed; and a control unit that controls an operation of opening or closing the valve unit. The control unit is capable of executing a flushing step in which when a cleaning solution or a disinfecting solution is caused to flow through the supply route, the valve unit is opened to allow the cleaning solution or the disinfecting solution flowing in the supply route to flow into the introduction route and through the line section to be discharged to an outside of the apparatus.

SYSTEM AND METHOD FOR PREPARATION OF A MEDICAL FLUID

Systems and apparatuses for preparing a medical fluid are disclosed. In an example embodiment, a system is configured to initially control a dosing of a first concentrate, while not feeding a second concentrate, under feedback control via a concentration sensor to a first pump to feed the first concentrate. When a concentration has reached a preselected concentration level, a value for a feeding parameter for the first pump to feed the first concentrate is determined. Additionally, the system is configured to control the dosing of both the first and the second concentrates by switching the feedback control via the concentration sensor, from control of the first pump to control of a second pump to feed the second concentrate. During this time, the system controls the first pump to feed the first concentrate based on the determined value of the feeding parameter. 1: A system for dosing of at least two concentrates into water for on-line preparation of a medical fluid , said system comprising:a main line for feeding of water;a first line with a first pump for feeding of a first concentrate into the main line at a first mixing point;a second line with a second pump for feeding of a second concentrate into the main line at a second mixing point;a concentration sensor arranged in the main line downstream of both the first and the second mixing points; and (i) initially control the dosing of the first concentrate, while not feeding the second concentrate, under feedback control via the concentration sensor to the first pump to feed the first concentrate, such that when a concentration measured by the concentration sensor has reached a first preselected concentration level, a value for a feeding parameter for the first pump to feed the first concentrate is determined, and', '(ii) after the determination of the value for the feeding parameter, control the dosing of both the first and the second concentrates by switching the feedback control via the concentration sensor, from ...

SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION INCLUDING MIXING AND HEATING THEREFORE

A peritoneal dialysis system includes a cycler including a pump actuator, a heater and a heating pan operable with the heater, and a disposable set operable with the cycler. The heating pan includes a sidewall forming a slot. The disposable set includes a pumping cassette and a heater/mixing container. The pumping cassette includes a pump chamber configured to be actuated by the pump actuator. Additionally, the heater/mixing container is in fluid communication with the pumping cassette and is sized to be received at the heating pan. The heater/mixing container includes a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port. 1. A peritoneal dialysis system comprising:a cycler including a control unit and a pump actuator under control of the control unit; and a pumping cassette having a pump chamber configured to be actuated by the pump actuator, and', 'a mixing container in fluid communication with the pumping cassette,, 'a disposable set operable with the cycler, the disposable set including'}wherein the control unit is programmed to promote mixing of at least two fluids by (i) causing the pump actuator to operate the pump chamber to pull the at least two fluids from the mixing container into the pump chamber, (ii) thereafter causing the pump actuator to operate the pump chamber to push the at least two fluids from the pump chamber to the mixing container, and (iii) repeating (i) and (ii) at least one time.2. The peritoneal dialysis system of claim 1 , wherein the control unit is configured such that after (i) claim 1 , (ii) and (iii) are performed claim 1 , a sample of the mixed at least two fluids is caused to undergo a test using a sensor claim 1 , and wherein at least one of prior to or after the test the sensor is bypassed or used for a different purpose.3. The peritoneal dialysis system of claim 1 , wherein after (i) claim 1 ...

DIALYSIS SYSTEM HAVING INDUCTIVE HEATING

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat. 1. A dialysis fluid system comprising:a dialysis fluid inlet;a dialysis fluid outlet;a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the dialysis fluid outlet,', 'a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and', 'a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding dialysis fluid to heat., 'an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including'}2. The dialysis fluid system of claim 1 , wherein the fluid flowpath and the conductive heater element are located within a heater housing in fluid communication with the dialysis fluid inlet and the dialysis fluid outlet.3. The dialysis fluid system of claim 2 , ...

Modular Reservoir Assembly for a Hemodialysis and Hemofiltration System

The present specification discloses a dialysis system having a reservoir module with a reservoir housing defining an internal space, a surface located within the internal space for supporting a container that contains dialysate, and a conductivity sensor located within the internal space, where the conductivity sensor has a coil, a capacitor in electrical communication with the coil, and an energy source in electrical communication with the circuit.

CONTAINER

The present invention relates to a combination of a container comprising a connecting portion and of a fluid preparation device, in particular a dialysis machine, which fluid preparation device is suitable for mounting and connecting the connecting portion of the container, wherein the fluid preparation device comprises at least one line which is in fluid communication with the interior of the container at least in the connected position of the container, the container being filled with a first medium, wherein the combination and preferably container comprises a reservoir containing a second medium, wherein the fluid preparation device comprises means for opening the reservoir so that the first and second medium are mixed with each other. 130505032305052303030301005056100. A combination of a container () comprising a connecting portion and of a fluid preparation device () , in particular a dialysis machine , which fluid preparation device () is suitable for mounting and connecting the connecting portion () of the container () , wherein the fluid preparation device () comprises at least one line () which is in fluid communication with the interior of the container () at least in the connected position of the container () , the container () being filled with a first medium , characterized in that the combination and preferably container () comprises a reservoir () containing a second medium , wherein the fluid preparation device () comprises means for opening () the reservoir () so that the first and second medium are mixed with each other.2525230525130525251525152. A combination according to claim 1 , wherein the at least one line () comprises a flushing fluid line () for feeding a fluid into the interior of the container () and a prepared fluid line ( claim 1 , ) for guiding the prepared fluid out of the interior of the container () claim 1 , wherein the flushing fluid line () and the prepared fluid line ( claim 1 , ) are formed by one and the same line () or by ...

Infusate caddy for a dialysis system

The invention relates to an infusate caddy for carrying, organizing, and operating infusate containers containing solutes for preparing dialysate and related fluids for use in dialysis. The infusate containers can be seated in the infusate caddy, and the infusate containers removed from the infusate caddy for restocking, cleaning, or resupply, as needed. The infusate caddy can be positioned or seated in a receiving compartment of a dialysis machine, and can also be removed, as needed, from the dialysis machine.

Dialysis priming steps using an infusate caddy

The invention relates to devices, systems, and methods for priming, disinfecting, and preparing dialysate and related fluids for use in dialysis. The dialysate and related fluids can be prepared from solutes obtained from infusate containers seated in an infusate caddy. The infusate caddy can be removably positioned in a receiving compartment of a dialysis machine. Similarly, the infusate containers containing the necessary solutes for preparing the dialysate and related fluids can also be removably positioned in the infusate caddy.

Dialysis systems and methods for modulating flow of a dialysate during dialysis using raman spectroscopy

The present invention is a system to continuously monitor, in real-time, the small molecules being dialyzed during hemodialysis treatment using Raman spectroscopy and press control algorithms. By monitoring the treatment, the amount of water needed per dialysis treatment is drastically reduced by optimizing analyte saturation and removal of wastes. This will significantly conserve water and reduce the cost of dialysis treatments, possibly reducing the amount of time necessary for dialysis treatment, improving quality of life for patients during and after treatment, and reducing the costs of building new treatment centers as well as operating costs.

Vehicle for providing a dialysis solution

The present invention relates to a power-driven land, water or air vehicle for providing dialysis solution receptacles, in particular bags, filled with dialysis solution, with the vehicle having a tank for receiving dialysis solution or for receiving a component of a dialysis solution, a storage region for the dialysis solution receptacles to be filled, and a filling station that is in fluid communication with the tank and that is configured to fill the dialysis solution receptacles with dialysis solution or with a component of the dialysis solution.

Dialysis system including automatic priming

A hemodialysis system comprising: a source of priming fluid; an extracorporeal circuit including an arterial line, a venous line, and a drip chamber; a level sensor operable with the drip chamber; a reversible blood pump operable with the extracorporeal circuit; a connection between the arterial and the venous line; and a priming sequence in which priming fluid from the source is pumped in a reverse pump direction through the extracorporeal circuit and reversibly in a normal pump direction through the extracorporeal circuit, wherein an output from the level sensor is used to determine when to stop pumping in at least one of the directions.

INTEGRATED WATER TESTING SYSTEM AND METHOD FOR ULTRA-LOW TOTAL CHLORINE DETECTION

A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing an iodide/water sample chamber and a reducing agent chamber. An electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the dialysis water. The electrode pair detects the amount of tri-iodide generated in proportion to the amount of active chloride in the dialysis water. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level. 1. A chlorine detection component comprising:a first chamber in fluid communication with an iodide reservoir and a source of at least partially purified water;a second chamber in fluid communication with a reducing agent reservoir, wherein the first and second chambers are separated by a membrane that allows an electrical charge but not fluid to pass between the chambers;an electrode pair associated with a voltage source, wherein one electrode of the electrode pair is in contact with an interior of the first chamber and the other electrode of the electrode pair is in contact with an interior of the second chamber; anda control unit connected operably to the electrode pair, the control unit configured to (i) at one time cause the voltage source to apply a source voltage to the electrode pair and (ii) at a second time stop applying the source voltage to the electrode pair and instead monitor a sensed electrical parameter through or across the electrode pair.2. The chlorine detection component of claim 1 , wherein at least one of the electrodes includes a metal selected from the group consisting of platinum claim 1 , gold claim 1 , stainless steel claim 1 , copper claim 1 , combinations thereof claim 1 , and alloys thereof.3 ...

VIRTUAL PATIENT DONATION

A system includes a device having a blood side, a solution side, and a semipermeable membrane structurally configured for diffusion of one or more solutes therethrough. The system also includes a first extracorporeal circuit having one or more first fluid connectors for connecting the blood side of the device to the vascular system of a first animal, a second extracorporeal circuit including one or more second fluid connectors for connecting the solution side of the device to the vascular system of a second animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source. 1. A system comprising:a device having a blood side and a solution side, the device including a semipermeable membrane structurally configured for diffusion of one or more solutes therethrough;a first extracorporeal circuit including one or more first fluid connectors for connecting the blood side of the device to the vascular system of a first animal;a second extracorporeal circuit including one or more second fluid connectors for connecting the solution side of the device to the vascular system of a second animal;a first pump in fluid communication with at least one of the first and second extracorporeal circuits; anda driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source.2. The system of claim 1 , wherein one or more of the first animal and the second animal is a human.3. The system of claim 1 , wherein one or more of the first animal and the second animal is a non-human.4. The system of claim 1 , wherein blood from one or more of the first animal and the second animal contains solutes that are desirous for transfer into blood of the other one of the first animal and the second animal.5. The system of claim 1 , wherein the driver includes a ...

DEVICE FOR ELECTROKINETIC FOCUSING AND ELECTRICAL DETECTION OF PARTICLES AND CHEMICAL SPECIES FACILITATED BY A POROUS ELECTRODE

High-throughput microfluidic devices comprising one or more fluidic microchannels each with at least one flow-through 3D structure comprising a 3D electrode, or alternatively a 3D permselective structure, and optional secondary bead bed(s) are disclosed. Such devices can be used for counter-flow focusing of charged species via ion concentration polarization and in situ quantification of electrokinetically enriched charged species from an ionically conductive solution by both optical and electrical detection. 1. A microfluidic device comprising:one or more fluidic microchannels, wherein the one or more fluidic microchannels are connected to at least one inlet and at least one outlet, wherein a background electrolyte solution is infused through at least one of the inlet(s), flows through the one or more fluidic microchannels, and is withdrawn from at least one of the outlet(s); andat least one flow-through 3D electrode within the microchannel wherein the 3D electrode comprises an electrode and microbeads,wherein at least one of the inlet(s) and/or at least one of the outlet(s) are connected to an electrode, andwherein the microbeads are contained within a primary bead bed which extends at least a portion of the width and length of the microchannel as defined by a bead bed structure within the microchannel.2. The device according to claim 1 , wherein at least a portion of the microbeads is in contact with the electrode in the flow-through 3D electrode claim 1 , and wherein at least a portion of said electrode extends outside of the channel for electrical connection.3. The device according to claim 1 , wherein the microbeads are conductive microbeads and voltage is applied to the inlet and/or outlet electrodes and the 3D electrode for enrichment and separation of charged species at an electric field gradient at the boundary of an ion depleted zone resulting from faradaic processes.4. The device according to claim 1 , wherein the microbeads are permselective membrane ...

Valve Actuation Systems and Related Methods

In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves. 1. A valve actuation system , comprising:a drive unit comprising an actuator configured to engage and move a plurality of valves disposed within a fluid cassette to selectively open and close each valve of the plurality of valves; anda positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the plurality of valves.2. The valve actuation system of claim 1 , wherein the drive unit is carried by the positioning frame.3. The valve actuation system of claim 1 , wherein the actuator is formed to mate with a complementary feature of each of the plurality of valves.4. The valve actuation system of claim 1 , wherein the actuator is configured to be controlled to apply a force to each valve of the plurality of valves to rotate each valve of the plurality of valves.5. The valve actuation system of claim 4 , wherein the actuator is configured to open and close each valve of the plurality of valves.6. The valve actuation system of claim 4 , wherein the force is a rotational force.7. The valve actuation system of claim 1 , wherein the positioning frame further comprises a first linear rail claim 1 , a second linear rail claim 1 , and a third linear rail along which the drive unit can be moved linearly to align the actuator with the selected valve.8. The valve actuation system of claim 7 , wherein the drive unit is configured to traverse the first claim 7 , second claim 7 , and third linear rails in a total time of up to about 0.5 seconds to about 2.0 seconds.9 ...

Dialysis Machine

A hemodialysis machine including a cartridge which defines a fluid pathway for delivering a dialysate solution base to a mixing pump, a main body having a platen which, in use, abuts the cartridge, the cartridge having a chassis with a platen side covered by a deformable membrane which, in use, abuts the platen, the chassis and membrane defining the flow path, the flow path including a dialysate base solution pump chamber, the platen having a dialysate base solution pump cavity which, collectively with the dialysate base solution pump chamber, forms a dialysate base solution pump for pumping dialysate base solution to the mixing pump by actuation of the membrane, wherein the volume of the dialysate base solution pump cavity is variable so as to allow a variation in the volume of dialysate base solution pumped from the dialysate base solution pump chamber to the mixing pump chamber on each stroke of the solution pump. 1. A hemodialysis machine includinga cartridge which defines a fluid pathway for delivering a dialysate solution base to a mixing pump,a main body having a platen which, in use, abuts the cartridge,the cartridge having a chassis with a platen side covered by a deformable membrane which, in use, abuts the platen, the chassis and membrane defining the flow path, the flow path including a dialysate base solution pump chamber,the platen having a dialysate base solution pump cavity which, collectively with the dialysate base solution pump chamber, fotms a dialysate base solution pump for pumping dialysate base solution to the mixing pump by actuation of the membrane,wherein the volume of the dialysate base solution pump cavity is variable so as to allow a variation in the volume of dialysate base solution pumped from the dialysate base solution pump chamber to the mixing pump chamber.2. The machine according to wherein the flow path further includes a mixing pump cavity which claim 1 , collectively with the mixing pump chamber claim 1 , forms a mixing pump ...

PUMPING CASSETTE

A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet. 1. (canceled)2. A fluid-balancing cassette comprising:a first and a second fluid-balancing pod, each chamber pod having a first port separated from an opposing second port by a flexible membrane, the flexible membrane dividing the fluid-balancing pod into variable volume first and second chambers, wherein a total fluid volume of the fluid-balancing chamber pod is a sum of the volumes of the first and second chambers;a first and a second diaphragm pump, an outlet of the first diaphragm pump having a valved connection to the second port of the first fluid-balancing pod and an outlet of the second diaphragm pump having a valved connection to the second port of the second fluid-balancing pod, wherein a full stroke volume of each diaphragm pump matches the total fluid volume of the fluid-balancing pod to which it is connected;a first fluid flowpath connecting a first inlet of the cassette to a first outlet of the cassette, wherein the first fluid flowpath has separate valved connections to the first port of the first fluid-balancing pod and to the first port of the second fluid-balancing pod; anda second fluid flowpath connecting a second inlet of the cassette to a second outlet of the cassette, wherein the second fluid flowpath has separate valved connections to an inlet of ...

Disposable Cartridge System for Use with Sorbent or Premixed Dialysate

A hemodialysis machine defining a closed loop fluid path for dialysate solution, the fluid path comprising: a first pump chamber having a pump inlet and a pump outlet, a dialyser having a dialyser inlet and a dialyser outlet, a conduit connected between the outlet of the first pump chamber and the inlet of the dialyser, a second pump chamber having a pump inlet and a pump outlet, a conduit connected between the outlet of the dialyser and the inlet of the second pump chamber, a dialysate regeneration device having a filter inlet and a filter outlet, a conduit connected between the outlet of the second pump chamber and the inlet of the dialysate regeneration device, a reservoir having a reservoir inlet and a reservoir outlet, a conduit connected between the outlet of the dialysate regeneration device and the inlet of the reservoir and, a conduit connected between the outlet of the reservoir and the inlet of the first pump chamber. 1. A hemodialysis machine defining a closed loop fluid path for dialysate solution , the hemodialysis machine comprising:a mixing chamber for receiving the dialysate solution;a first flow balance chamber connected to the mixing chamber;a second flow balance chamber connected to the first flow balance chamber;a dialyser for cleaning the dialysate solution, the dialyser connected between the first flow balance chamber and the second flow balance chamber; anda filter for cleaning the dialysate solution, the filter connected between the second flow balance chamber and the mixing chamber;wherein the mixing chamber and first and second flow balance chambers are provided on a cartridge removably mountable in the hemodialysis machine.2. A hemodialysis machine defining a closed loop fluid path for dialysate solution , the hemodialysis machine comprising:a fixed volume of dialysate solution;a mixing chamber for receiving the dialysate solution;a first flow balance chamber connected to the mixing chamber;a second flow balance chamber connected between ...

Urease Purification And Purified Urease Products Thereof And Sorbent Cartridges, Systems And Methods Using The Same

Methods for purifying urease are described that make use of a precipitating agent such as ammonium sulfate to obtain urease as a precipitate. The method can involve use of a solubilizing agent, such as a citrate-containing solution, to dissolve the precipitate. The method can involve the use of a sugar to provide protected urease in a sugar-urease solution and immobilization of the urease. The method can involve freeze drying of the immobilized urease. A sugar-urease preparation and an immobilized urease, and a sorbent cartridge containing the urease are described as well as methods to conduct dialysis. 1. A method of purifying urease , comprising:a) mechanically separating an extract mixture to provide a separated solution, wherein the extract mixture comprises an extracting agent in solution and a comminuted source of urease;b) combining ammonium sulfate with the separated solution to precipitate urease in the separated solution to provide a precipitate-containing mixture;c) mechanically separating the precipitate-containing mixture to collect the precipitate;d) dissolving the precipitate collected to provide a urease-containing solution;e) combining the urease-containing solution with a sugar to provide a sugar-urease solution;f) combining the sugar-urease solution and a sorbent material to immobilize urease on the sorbent material to provide an immobilized urease preparation; andg) optionally freeze drying the immobilized urease preparation to provide an immobilized urease product.2. The method of claim 1 , wherein the source of urease is a botanical source of urease claim 1 , fungal source of urease claim 1 , algal source of urease claim 1 , bacterial source of urease claim 1 , invertebrate source of urease claim 1 , or any combination thereof.3. The method of claim 1 , wherein the source of urease comprises jack beans claim 1 , sword beans claim 1 , soy beans claim 1 , or any combination thereof.4. The method of claim 1 , wherein the source of urease is jack ...

Peritoneal dialysate purity control system

The invention relates to devices, systems, and methods for generating a peritoneal dialysate having purity and sterility characteristics suitable for Peritoneal Dialysis (PD). The peritoneal dialysate can be generated from water of variable quality using a purity control system having one or more ultrafilters for sterilization of the peritoneal dialysate Peritoneal dialysate generation system and related methods are described that can generate sterilized peritoneal dialysate and deliver peritoneal dialysis therapy to a patient.

Rotary Valves for Dialysis Systems

In one aspect, a dialysis fluid cassette includes an inlet fluid line, multiple outlet fluid lines, and a valve including an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the multiple outlet fluid lines. 1. A dialysis fluid cassette , comprising:an inlet fluid line;a plurality of outlet fluid lines; anda valve comprising an actuation feature by which the valve can be rotated to fluidly communicate the inlet fluid line with a selected fluid line of the plurality of outlet fluid lines.2. The dialysis fluid cassette of claim 1 , wherein the actuation feature comprises a surface profile that is formed to be engaged by an actuator for rotating the valve.3. The dialysis fluid cassette of claim 1 , wherein the actuation feature has a polygonal shape.4. The dialysis fluid cassette of claim 1 , wherein the actuation feature has a symmetric shape.5. The dialysis fluid cassette of claim 1 , wherein the actuation feature has an asymmetric shape.6. The dialysis fluid cassette of claim 1 , wherein the actuation feature comprises a recessed profile.7. The dialysis fluid cassette of claim 1 , wherein the actuation feature comprises a protrusion that extends from a main body of the valve.8. The dialysis fluid cassette of claim 1 , wherein the valve further comprises an indicator having an orientation that corresponds to the selected fluid line.9. The dialysis fluid cassette of claim 1 , wherein the valve further comprises:a valve body defining an internal fluid pathway that can fluidly communicate the inlet fluid line with the selected fluid line; anda spring that is configured to move the valve body to enable or disable an operation of the valve.10. The dialysis fluid cassette of claim 9 , wherein the valve body is movable to:a first position at which the internal fluid pathway is aligned with the inlet fluid line and the plurality of outlet fluid lines to enable the operation of the valve, anda second ...

Intelligent Adjustment of Dialysis Machine Operations

A remote service is implemented to automatically aggregate data across hemodialysis patients and hemodialysis patients and determine updated treatment options for patients to increase well-being and optimize performance of the hemodialysis machines. Patients or caregivers operating a hemodialysis machine or a local or remote user computing device associated with the hemodialysis machine can provide feedback regarding the patient's well-being to the remote service. The feedback can be provided at any of one or more times pre-treatment, during treatment, or post-treatment. Furthermore, the hemodialysis machine can be configured with one or more sensors that transmit data pertaining to device state of the hemodialysis machine, such as information about blood, dialysate used, saline solution, pump pressure, air trap and air detector, hemodialysis machine information (e.g., make and model), etc.

BLOOD PURIFICATION SYSTEM AND SOLUTION-PREPARATION-DETERMINING APPARATUS

A system and a solution-preparation-determining apparatus which determines whether additional preparation of an undiluted dialysate solution is necessary. A blood purification system includes a solution-preparing unit that prepares an undiluted dialysate solution, a dialysate-supplying unit that prepares a working dialysate at a predetermined concentration by diluting the undiluted dialysate solution received from the solution-preparing unit, a blood-purification-treatment section that includes a blood-purification-apparatus group including at least one blood purification apparatus that performs blood purification treatment in which the working dialysate is supplied to the blood-purification-apparatus group, and a determining unit that determines whether additional preparation of the undiluted dialysate solution is necessary from a result of comparison between an estimated number of treatment sessions expected to be performed by the blood-purification-apparatus group throughout a predetermined period and an actual number of treatment sessions performed by the blood-purification-apparatus group as of a time point during the predetermined period. 1. A blood purification system comprising:a solution-preparing unit that prepares an undiluted dialysate solution;a dialysate-supplying unit that prepares a working dialysate at a predetermined concentration by diluting the undiluted dialysate solution received from the solution-preparing unit and supplies the working dialysate;a blood-purification-treatment section that includes a blood-purification-apparatus group including at least one blood purification apparatus that performs blood purification treatment in which the working dialysate prepared by the dialysate-supplying unit is supplied from the dialysate-supplying unit to the blood-purification-apparatus group; anda determining unit that executes a first determining step of determining whether additional preparation of the undiluted dialysate solution by the solution- ...

Filtration System for Preparation of Fluids for Medical Applications

A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient. 115.-. (canceled)16. A treatment system for performing a treatment on a patient , the treatment system comprising:a source of fluid;a container for treatment fluid;the source of fluid being connected by a line to convey fluid through a filter and into the container for treatment fluid;the container for treatment fluid being a disposable container that permits flow into and out of it;the treatment system having a controller that controls a pump that regulates the flow of fluid from the source of fluid to the container for treatment fluid.17. The system of claim 16 , wherein the pump is regulated responsively to a measurement of pressure.18. The system of claim 16 , further comprising a controller that controls the administration of heat to the container for treatment fluid.19. The system of claim 16 , further comprising a component that withdraws the treatment fluid from the container for treatment fluid and conveys treatment fluid to and from a patient.20. A system for generating a batch of treatment fluid at a point of use claim 16 , comprising:a fluid circuit having a water source line, a ...

SYSTEM AND METHOD FOR PREPARATION OF A MEDICAL FLUID

The present invention concerns a system and a method for dosing of at least two concentrates into water for on-line preparation of a medical fluid. The system comprises a main line () for feeding of water, a first line () with a first pump () for feeding of a first concentrate into the main line at a first mixing point (), a second line () with a second pump () for feeding of a second concentrate into the main line at a second mixing point (). A main concentration sensor () measures the concentration in the main line () downstream both the first and the second mixing points. Initially, while not feeding any of the second concentrate, the control of the dosing of the first concentrate is under feedback control from the main concentration sensor () to the first pump (). At a certain point in time a value for a feeding parameter for the first pump () is determined and the feedback control from the main concentration sensor () is moved, from control of the first pump () to control of the second pump (). Then the value for the feeding parameter is used for control of the first pump (). 1. A system for dosing of at least two concentrates into water for on-line preparation of a medical fluid , said system comprising:a main line for feeding of water;a first line with a first pump for feeding of a first concentrate into the main line at a first mixing point;a second line with a second pump for feeding of a second concentrate into the main line at a second mixing point;a main concentration sensor arranged in the main line downstream of both the first and the second mixing points; andwherein the system is configured to(i) initially control the dosing of the first concentrate, while not feeding any of the second concentrate, under feedback control from the main concentration sensor to the first pump for feeding of the first concentrate, such that when the concentration measured by the main concentration sensor has reached a first preselected concentration level, a value for a ...

DIALYSIS BASE UNIT AND DIALYSIS SYSTEM

A dialysis base unit that is provided separately from a dialysate supply device for delivering dialysate and performs hemodialysis using the dialysate delivered from the dialysate supply device. The dialysis base unit includes a dialysate supply device identifying unit capable of identifying the dialysate supply device connected to the dialysis base unit. A dialysis system includes the dialysate supply device for delivering dialysate and the dialysis base unit. 1. A dialysis base unit that is provided separately from a dialysate supply device for delivering dialysate and performs hemodialysis using the dialysate delivered from the dialysate supply device , the dialysis base unit comprising:a dialysate supply device identifying unit capable of identifying the dialysate supply device connected to the dialysis base unit.2. The dialysis base unit according to claim 1 , further comprising:a checking unit that checks whether or not the dialysate supply device identified by the dialysate supply device identifying unit is correct.3. The dialysis base unit according to claim 1 , further comprising:a monitor for displaying a dialysis status or configurable dialysis conditions; anda display control unit that changes contents displayed on the monitor according to the dialysate supply device identified by the dialysate supply device identifying unit.4. The dialysis base unit according to claim 1 , further comprising:a communication unit for communicating with the dialysate supply device; anda dialysate supply device control unit that controls the dialysate supply device via the communication unit,wherein the dialysate supply device control unit changes a control condition according to the dialysate supply device identified by the dialysate supply device identifying unit.5. The dialysis base unit according to claim 1 , further comprising:an abnormality detecting unit that detects abnormality during hemodialysis; and a notification unit that notifies detection of abnormality when ...

DIALYSATE CONCENTRATION MEASUREMENT SENSOR DIAGNOSIS

A diagnosis method for a conductivity sensor for a dialysis fluid preparation apparatus and personal dialysis apparatus, that mix water, an A fluid and a B fluid in predetermined proportions respectively to prepare a dialysis fluid and measures the concentration of the prepared dialysis fluid by concentration measurement means is described. The diagnosis method and the respective apparatus is based in measuring the A fluid without the B fluid being present in the solution. 11101. A diagnosis method for a dialysis fluid preparation apparatus ( , ) that comprises:{'b': 2', '102, 'a water feed passage (, ) to feed water,'}{'b': 3', '103', '3', '103', '2', '102, 'an A fluid passage (, ) to feed an A fluid containing sodium chloride as a principal ingredient together with at least one other ingredient, the A fluid passage (, ) being connected with the water feed passage (, ),'}{'b': 4', '104', '4', '104', '2', '102', '20', '23', '27', '120', '123', '127', '20', '23', '27', '120', '123', '127', '3', '103', '2', '102, 'i': a', 'a', 'a', 'a', 'a', 'a, 'a B fluid passage (, ) to feed a B fluid composed of a sodium bicarbonate aqueous solution, the B fluid passage (, ) being connected with the water feed passage (, ), and concentration measurement means (, , , , , ) provided with a detection unit (, , , , , ) downstream of connecting positions of the A fluid passage (, ) on the water feed passage (, ),'}the diagnosis method comprising mixing the water, the A fluid and the B fluid in predetermined proportions respectively to prepare a dialysis fluid, and{'b': 20', '23', '27', '120', '123', '127, 'measuring a concentration of the prepared dialysis fluid by the concentration measurement means (, , , , , ), characterized in that'}{'b': 3', '103', '2', '102', '2', '102', '20', '23', '27', '120', '123', '127', '20', '23', '27', '120', '123', '127, 'before preparing the dialysis fluid, feeding the A fluid from the A fluid passage (, ) to the water feed passage (, ) so as to flow ...

Modular assembly for a portable hemodialysis system

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

Implantable fluid management system for treating heart failure

A device and methods for treating renal failure are disclosed. One embodiment of the device is an implantable peritoneal dialysis device. When in use, the device can have a semi-permeable reservoir implanted in the peritoneal cavity. The reservoir can receive blood waste and drain through one or more conduits, via a pump, to the biological bladder. Solids and/or a solution benefiting dialysis can be pumped to the reservoir and/or implanted in the peritoneal cavity.

DIALYSIS SYSTEM AND METHODS

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration. 1. A method of priming a tubing set and a dialyzer of a dialysis system , comprising the steps of:connecting an arterial line of a tubing set to a venous line of the tubing set to form a continuous loop in the tubing set;pumping air out of the tubing set with an air pump;pulling a flow of fluid from a fluid source into the tubing set with the air pump;operating a blood pump of the dialysis system in a forward operating mode to flow fluid from the fluid source into the tubing set in a first direction; andoperating the blood pump in a reverse operating mode to flow fluid through the tubing set in a second direction opposite to the first direction.2. The method of claim 1 , wherein the pulling step further comprises pulling the fluid into the tubing set with the air pump until the fluid is detected by a first level sensor in a venous drip chamber.3. The method of claim 2 , wherein operating the blood pump in the forward operating mode further comprises operating the blood pump in ...

Dialysis systems including therapy prescription entries

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

Hemodialysis system including a disposable cassette

A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.

Dry Acid Concentrate In Granulate Form

The present invention relates to a novel dry acid concentrate (DAC) for a dialysis liquid and to a dialysis liquid, which is made from said concentrate, and which may be used for purifying blood. The invention further relates to a method of making the dry acid concentrate as well as the dialysis liquid. It also relates to a container () comprising said acid concentrate, and which is—in certain embodiments—specially adapted to a dialysis unit. 115-. (canceled)16. A dry concentrate suitable to form a liquid acid concentrate or a part of a liquid acid concentrate usable in dialysis comprisinga first component comprising a first granulate comprising a plurality of first granules comprising sodium chloride and glucose, anda second component comprising a second granulate comprising a plurality of second granules, wherein said second granules comprise at least one further physiologically acceptable electrolyte, which is different from sodium chloride,or a second component in the form of a powder, wherein said powder comprises at least one further physiologically acceptable electrolyte which is different from sodium chloride, andwherein said powder comprises a plurality of fine particles, wherein each particle comprises or consists of one of said at least one further physiologically acceptable electrolyte,or a mixture of said second granulate and said powder;wherein said concentrate is substantially free of a base component that is suitably used in dialysis.17. The dry concentrate according to claim 16 , wherein the first and the second components comprise or consist of said first and second granulates.18. The dry concentrate according to claim 17 , wherein the first granules of the first component exhibit a higher average equivalent diameter than the second granules of the second component.19. The dry concentrate according to claim 16 , wherein the first granulate comprises at least 50 wt-% of first granules claim 16 , respectively based on the total weight of the first ...

CASSETTE SYSTEM INTEGRATED APPARATUS

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes. 120-. (canceled)21. An integrated cassette system comprising a fluid mixing cassette , a middle cassette and a fluid balancing cassette , the middle cassette interposed between the mixing cassette and the balancing cassette; a mixing chamber interposed between and fluidly connected to the mixing cassette and the middle cassette, the mixing chamber having a first fluid port connected to the mixing cassette and a second fluid port connected to the middle cassette;', 'a mixing cassette reciprocating membrane pump interposed between and fluidly connected to the mixing cassette and the middle cassette, the mixing cassette reciprocating membrane pump configured to pump fluid to the mixing chamber;', 'a balancing chamber interposed between the middle cassette and the balancing cassette, the balancing chamber comprising a flexible membrane separating the balancing chamber into a first fluid compartment and a second fluid compartment, the first fluid compartment in fluid communication with the middle cassette and the second fluid compartment in fluid communication with the fluid balancing cassette;', 'a balancing cassette reciprocating membrane pump interposed between and fluidly connected to the middle cassette and the balancing cassette, the balancing cassette reciprocating membrane pump configured to pump fluid into the first fluid compartment of the balancing chamber, displacing an equal volume of fluid from the second fluid compartment of the ...

A SYSTEM AND A METHOD FOR PRODUCING MICROBIOLOGICALLY CONTROLLED FLUID

A method and a system () comprising an integrated water purifying apparatus () with a pre-filter circuit () including a particle filter and an activated carbon filter arranged to produce pre-treated water; a fluid circuit () arranged to receive pre-treated water from the pre-filter circuit (), the fluid circuit () includes an RO-pump () and a Reverse Osmosis, RO, device, () arranged to produce purified water; a heating device () arranged to heat purified water from the RO device () to a temperature above 65°; the water purifying apparatus () is further arranged to heat disinfect the fluid circuit () using the heated purified water. The system () further comprises a line set () connected to the purified water outlet connector () at a water line connector () of the line set (), wherein the line set () includes at least one sterile sterilizing grade filter () arranged to filter the purified water into sterile purified water. 117-. (canceled)18. A system comprising:a line set connected to a purified water outlet connector, wherein the line set includes at least one sterilizing filter; and (i) a pre-filter circuit connected to a water inlet for receiving water from a water source, wherein the pre-filter circuit includes a particle filter and an activated carbon filter, wherein each of the particle filter and the activated carbon filter are arranged to filter water received via the water inlet to produce pre-treated water,', a pump,', 'a reverse osmosis device, and', 'a heating device arranged to heat purified water output from the reverse osmosis device to a temperature above 65° C., and, '(ii) a fluid circuit arranged to receive pre-treated water from the pre-filter circuit and to produce purified water, wherein the fluid circuit includes'}, '(iii) the purified water outlet connector,, 'a water purifying apparatus fluidly connected with the line set, the water purifying apparatus including'} pump pre-treated water through the reverse osmosis device using the pump,', ' ...

SYSTEM AND METHOD FOR CONNECTING A CONCENTRATE CONTAINER WITH A BLOOD TREATMENT DEVICE WITHOUT LEAKAGES

The present invention refers to a container comprising a connection portion allowing for an easy, efficient and more hygienic connection of the container to a fluid dosing unit of a blood treatment device. According to the present invention the fluid dosing unit comprises a valve that fluidically closes the fluid dosing unit if no container is connected to the fluid dosing unit and that opens the fluid dosing unit upon connection of a container to the fluid dosing unit. Thus, undesired spillages potentially arising upon disconnection of the container from the fluid dosing unit can be avoided. 1. Container for concentrate , comprising:a main body for containing concentrate,a connection portion having a flat end surface facing away from the main body and an opening through that the main body can be filled with concentrate,a inlet through that fluid can be supplied to the main body and an outlet through that fluid can be withdrawn from the main body, wherein at least in the outlet a fluid permeable actor is arranged that is configured to open a valve in a fluid line of a fluid dosing unit when the container is connected to the fluid dosing unit to fluidically couple the container to the fluid dosing unit.2. Container according to claim 1 , wherein the fluid permeable actor comprises a spike configured to open the valve and at least one lumen to conduct fluid.3. Container according to claim 1 , wherein the outlet and the inlet each project along a straight line traversing the connection portion from the flat end surface facing away from the main body to a flat end surface facing the main body.4. Container according to claim 1 , wherein the container comprises two attachment elements arranged at two opposing sides of the connection portion and configured to reversibly attach the container to two corresponding attachment elements present on a blood treatment device claim 1 , whereinthe two attachment elements project in a first direction and the outlet and inlet project ...

SYSTEM AND METHOD FOR OPENING A CONCENTRATE CONTAINER AND CONNECTING THE CONCENTRATE CONTAINER TO A BLOOD TREATMENT DEVICE

The present invention refers to a system and method for opening a concentrate container without the need for a human to directly handle the concentrate container and connecting the concentrate container to a blood treatment device. Aspects of the invention are directed to a container for concentrate and a blood treatment device. 1. Container for concentrate , comprising:a main body for containing concentrate,a connection portion having a flat end surface and configured to connect the container to a blood treatment device,two attachment elements arranged at two opposing sides of the connection portion and configured to reversibly attach the container to two corresponding attachment elements present on a blood treatment device, andtwo connection elements each comprising an opening at the fiat end surface of the connection portion and configured to interact with two corresponding connection elements present on a blood treatment device to fluidically couple the container with the blood treatment device by insertion of the connection elements present on the blood treatment device into the connection elements of the container, andat least one opening element configured to interact with a blood treatment device to remove a lid from the container.2. Container according to claim 1 , wherein the at least one opening element configured to interact with a blood treatment device to remove a lid from the container has the form of a lever preferably made of a stiff material that is arranged between the lid and the flat end surface of the connection portion and is movable relative to the flat end surface claim 1 , preferably in a direction away from the flat end surface.3. Container according to claim 2 , wherein the lever comprises a curved section preferably at a front edge of the lever and the curved section is preferably curved away from the flat end surface of the connection portion claim 2 ,4. Container according to claim 1 , wherein the at least one opening element ...

SYSTEM AND METHOD FOR CONNECTING A CONCENTRATE CONTAINER WITH A BLOOD TREATMENT DEVICE

The present invention refers to a system and method for connecting a concentrate container with a blood treatment device with improved hygiene. Furthermore, the invention refers to a container and blood treatment device to be used in a method according to the present invention. 1. Container for concentrate , comprising:a main body for containing concentrate,a connection portion having a flat end surface and configured to connect the container to a blood treatment device,two attachment elements arranged at two opposing sides of the connection portion and configured to reversibly attach the container to two corresponding attachment elements present on a blood treatment device, andtwo connection elements each comprising an opening at the flat end surface of the connection portion and configured to interact with two corresponding connection elements present on a blood treatment device to fluidically couple the container with the blood treatment device by insertion of the connection elements present on the blood treatment device into the connection elements of the container, whereinthe two attachment elements project in a first direction and the two connection elements project in a second direction that is oriented essentially at right angles to the first direction.2. Container according to claim 1 , wherein the second direction in that the two connection elements project is oriented essentially in parallel to the longitudinal axis of the main body of the container and the two connection elements each have the form of a hollow cylinder opened at the flat end surface of the connection portion.3. Container according to claim 1 , wherein the attachment elements are each formed as a hook or as a hollow cylinder.4. Container according to claim 1 , wherein the two connection elements are sealed by a lid in the form of a flexible film removably attached to the flat end surface of the connection portion and wherein the flexible film can be peeled off the flat end surface of the ...

POTASSIUM LOADED ION-EXCHANGE MATERIAL FOR USE IN A DIALYSATE REGENERATION SYSTEM

Systems and methods for managing the potassium concentration of a dialysate fluid during hemodialysis therapy using cation exchange materials that do not release sodium ions. 1. A system for kidney replacement therapy , comprising:a dialysate flow loop for circulating a dialysate through a dialyzer where at least one waste species enters the dialysate;a dialysate regeneration unit for decreasing the concentration or conductivity of at least one waste species and releasing potassium ions to the dialysate; anda potassium management system for modifying the potassium ion concentration of the dialysate in the dialysate flow loop, the potassium-modified fluid having a potassium ion concentration or conductivity that is higher or lower than the fluid in the dialysate flow loop.2. The system of claim 1 , further comprising a deionization resin to lower the sodium ion concentration of the dialysate entering the potassium management system.3. The system of claim 2 , wherein the deionization resin substantially removes sodium ions from the dialysate entering the potassium management system.4. The system of claim 1 , wherein the potassium management system further comprises a deionization resin to lower the potassium ion concentration from the dialysate.5. The system of claim 1 , further comprising a control pump connected to an ultrafiltrate reservoir that removes or adds fluid to the dialysate flow loop downstream from the dialyzer claim 1 , wherein operation of the control pump in an efflux direction causes net removal of fluid from the blood on an extracorporeal side of a membrane in the dialyzer and operation of the control pump in an influx direction causes net addition of fluid to the blood on the extracorporeal side of the membrane.6. The system of claim 1 , further comprising a potassium ion or conductivity detector that measures the conductivity or potassium ion concentration of the dialysate.7. The system of claim 1 , wherein the potassium management system is an ...

Filtration System for Preparation of Fluids for Medical Applications

A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.

PERITONEAL DIALYSIS SYSTEM INCLUDING A WATER TREATMENT DEVICE

A peritoneal dialysis system is disclosed. An example peritoneal dialysis system includes a water treatment device including a water treatment processor and a first memory and a peritoneal dialysis (“PD”) machine including a PD processor and a second memory. The PD machine is configured to mix water treated by the water treatment device with at least one concentrate to produce a peritoneal dialysis fluid for treatment. The example peritoneal dialysis system also includes a data link between the water treatment processor and the PD processor. The water treatment device is configured to prepare an amount of treated water and, upon communication between the water treatment processor and PD processor over the data link, deliver the amount of the treated water to the PD machine for use in mixing the peritoneal dialysis fluid for the treatment. The treated water has a purity corresponding to an injectable quality or a sterile quality. 1. A peritoneal dialysis system comprising:a water treatment device including a water treatment processor and a water treatment memory;a peritoneal dialysis (“PD”) machine including a PD processor and a PD memory, the PD machine configured to mix water treated by the water treatment device with at least one concentrate to produce a peritoneal dialysis fluid for treatment; anda data link between the water treatment processor and the PD processor,wherein (i) the PD processor uses instructions stored in the PD memory to determine a treated water flowrate and send the treated water flowrate via the data link to the water treatment processor or (ii) the PD processor uses the instructions stored in the PD memory to send a parameter via the data link to the water treatment processor, wherein the water treatment processor determines the treated water flowrate from the parameter, and wherein the water treatment processor causes the water treatment device to deliver treated water to the PD machine at the treated water flowrate.2. The peritoneal ...

DISPOSABLE CASSETTE AND SYSTEM FOR DIALYSIS

A disposable cassette and system for dialysis are disclosed. An example disposable cassette includes a rigid portion, a fluid source inlet configured to be placed in fluid communication with a fluid source, and a fluid pumping receptacle placed in fluid communication with the fluid source inlet. The fluid pumping receptacle is configured to operate with a fluid pump actuator to pump fluid from the fluid source. The example disposable cassette also includes a dampening chamber formed as part of the rigid portion and in fluid communication with the fluid pumping receptacle. The dampening chamber is sized and arranged to reduce pressure fluctuations in the fluid delivered from the fluid pumping receptacle. The example disposable cassette further includes an outlet in fluid communication with the dampening chamber. The outlet provides dialysis fluid for a dialysis treatment. 1. A disposable cassette for a dialysis treatment comprising:a rigid portion;a fluid source inlet configured to be placed in fluid communication with a fluid source;a fluid pumping receptacle placed in fluid communication with the fluid source inlet, the fluid pumping receptacle configured to operate with a fluid pump actuator to pump fluid from the fluid source;a dampening chamber formed as part of the rigid portion and in fluid communication with the fluid pumping receptacle, the dampening chamber sized and arranged to reduce pressure fluctuations in the fluid delivered from the fluid pumping receptacle; andan outlet in fluid communication with the dampening chamber, the outlet for providing dialysis fluid for the dialysis treatment.2. The disposable cassette of claim 1 , further comprising a concentrate inlet for communication fluidly with a concentrate source.3. The disposable cassette of claim 2 , wherein fluid from the fluid source is mixed with concentrate from the concentrate source to form the dialysis fluid.4. The disposable cassette of claim 3 , wherein the fluid from the fluid source is ...

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line at a set point based on the physician prescription; starting from the initial patient plasma conductivity, estimated at the beginning of the treatment, and based on the target plasma conductivity/sodium concentration which is equivalent to the dialysate conductivity/sodium concentration prescribed, the control unit determines the minimum constant gradient between dialysis fluid and plasma conductivity/concentration to be maintained during treatment to achieve the conductivity/concentration target in the patient plasma at the end of the session. 118-. (canceled)19: An apparatus for extracorporeal blood treatment comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood circuit including a blood withdrawal line connected to an inlet of the primary chamber and a blood return line connected to an outlet of the primary chamber, said blood lines being configured for connection to a patient cardiovascular system;a dialysis supply line connected to an inlet of the secondary chamber;a dialysis effluent line connected to an outlet of the secondary chamber;a preparation device configured to prepare a dialysis fluid, the preparation device connected to said dialysis supply line and including a regulator configured to regulate the composition of the dialysis fluid;a sensor configured to measure a parameter value of a dialysate in the dialysis effluent line, said parameter value of the dialysate being at least one selected from the group consisting of a conductivity of the dialysate and a concentration of at least a substance in the dialysate; set a parameter value for ...

APPARATUS FOR AN EXTRACORPOREAL BLOOD TREATMENT

The present invention relates to an apparatus for an extracorporeal blood treatment having an extracorporeal blood circuit in which a dialyzer is arranged and having a dialyzate circuit, wherein the blood circuit is in fluid communication with a first chamber and the dialyzate circuit is in fluid communication with a second chamber of the dialyzer, and wherein the two chambers are separated from one another by a semipermeable membrane, with a dialyzate pump for a conveying of the dialysis solution being present in the dialyzate circuit, wherein the apparatus has a control unit that is configured to operate the apparatus in a first phase and in a second phase following the first phase, wherein the dialyzate pump is operated with a smaller flow rate in the first phase than in the second phase and/or wherein the dialyzate pump conveys a dialysis solution in the first phase that is of a higher concentration with respect to at least one component than in the second phase. 1. An apparatus for an extracorporeal blood treatment having an extracorporeal blood circuit in which a dialyzer is arranged and having a dialyzate circuit , wherein the blood circuit is in fluid communication with a first chamber and the dialyzate circuit is in fluid communication with a second chamber of the dialyzer , and wherein the two chambers are separated from one another by a semipermeable membrane , with a dialyzate pump for a conveying of the dialysis solution being present in the dialyzate circuit , characterized in that the apparatus has a control unit that is configured to operate the apparatus in a first phase and in a second phase following the first phase , wherein the dialyzate pump is operated with a smaller flow rate in the first phase than in the second phase and/or wherein the dialyzate pump conveys a dialysis solution in the first phase that is of a higher concentration with respect to at least one component than in the second phase.2. An apparatus in accordance with claim 1 , ...

METHOD AND APPARATUS FOR PREMIXING DIALYSATE

An apparatus for premixing fluids to form dialysate for an extracorporeal blood treatment includes at least a first feed portion for supplying at least a first fluid from at least a first fluid reservoir, at least a second feed portion for supplying at least a second fluid from at least a second fluid reservoir, a premixing portion being configured to premix fluids supplied via the feed portions in counter flow to form a fluid mixture and at least one drain portion for draining the fluid mixture premixed in the premixing portion as dialysate. A method carries out appropriate steps. In a conductivity measurement along the drain portion the conductivity of the premixed fluid mixture is measured by means of a digital filter adapted to be parameterized based on at least two state variables of the premixing process at least in two phases with a first predictive phase and a second corrective phase. 110.-. (canceled)11. An apparatus for premixing fluids to form a dialysate for an extracorporeal blood treatment , comprising:at least a first feed portion for supplying at least a first fluid from at least a first fluid reservoir;at least a second feed portion for supplying at least a second fluid from at least a second fluid reservoir;a premixing portion which is configured to premix the first and second fluids supplied via the first and second feed portions in counter flow to form a fluid mixture; andat least one drain portion for draining the fluid mixture premixed in the premixing portion as the dialysate.12. The apparatus according to claim 11 , wherein the at least a first fluid is osmotic water and the at least a second fluid is a concentrate of a substance to be used for the extracorporeal blood treatment.13. The apparatus according to claim 12 , wherein the concentrate is a bicarbonate concentrate.14. The apparatus according to claim 11 , wherein in the at least one drain portion a fluid column for generating a constant primary pressure is provided which is configured ...

UNIT FOR PREPARING AT LEAST ONE SOLUTION OF CONCENTRATES FOR HAEMODIALYSIS AND METHOD FOR PREPARING SAID SOLUTION

A unit () for preparing at least one hemodialysis concentrates solution (CH), the solution comprising solid water-soluble materials comprising at least sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl) and magnesium chloride (MgCl). This unit has a modular structure and includes the following modules: a sampling module (MPRE) to take at least a sample of each of the raw materials to be dissolved in a volume of purified water, a laboratory module (MLAB) arranged to analyze each of the samples of said raw material to control compliance and quality, a weighing module (MPES) to determine the quantity in weight of the raw material to be introduced in the predetermined volume of purified water, a solution preparation module (MPRE) to introduce and dissolve the quantity in weight of raw material in the predetermined volume of purified water, and at least one module (MCON) for packaging the prepare hemodialysis concentrate solution. 118-. (canceled)1910. A unit () for preparing at least one hemodialysis concentrate solution (CH) , said solution comprising solid water-soluble materials comprising at least sodium chloride (NaCl) , potassium chloride (KCl) , calcium chloride (CaCl) and magnesium chloride (MgCl) , including means for preparing said solution by introducing successively predetermined quantities of said solid water-soluble materials in a predetermined volume of purified water in a mixing container , means for carrying out individually a dosage control of said solid water-soluble materials introduced in said predetermined volume of the purified water and means for individually carrying out a compliance check of the concentrates solution obtained at an end of the process , wherein said unit comprises:a sampling module (MPRE) to take at least a sample of each raw material to be dissolved in said volume of the purified water,a laboratory module (MLAB) arranged to analyze a sample of each said raw material to control raw material compliance and ...

Automatic dialysate detection in dialysis machines

A method for operating a dialysis machine to conduct a dialysis treatment on a patient (e.g., a peritoneal dialysis machine) may include transferring dialysate from a first bag, and automatically determining the dialysate from the first bag has completely transferred. After determining the dialysate has completely transferred from the first bag, switching from the first bag to a second bag of dialysate. The method may further include transferring dialysate from the second bag in response to the detection of the completed transfer of the first bag, and automatically determining the dialysate from the second bag has completely transferred. The method may further include determining if the respective first or second bag has completely transferred by comparing a dialysate bag volume transferred to the patient to a detected volume of the respective first or second bag. Systems with dialysis machines for performing such a method are disclosed as well.

TREATMENT FLUID PREPARATION SYSTEM

A system for purifying incoming fluid is provided that is modular and includes a heat exchanger module, an evaporator-condenser module and a compressor. The system is configured to facilitate passive drainage of the purified fluid for collection. The system components are arranged in a stacked configuration to facilitate gravitational flow of the purified fluid such that the purified fluid drains passively for collection. A system for preparation of ready-to-use treatment fluid is also provided including the modular fluid purification system, a preparation station and a coupling device. The components are configured to be retained in a portable carrier that is manually operable for improved access to and mobility of the components. A coupling device for use in connecting flow channels of a plurality of components and for use in preparing ready-to-use dialysate is also provided, A further system for preparation of a receptacle and a ready-to-use treatment fluid in the receptacle is also provided. 1. A coupling device for connecting flow channels of a plurality of components and for preparing ready-to-use treatment fluid , the coupling device comprising a plurality of interconnected internal channels , each channel having a first coupling zone and a second coupling zone recessed in the channel relative to the first coupling zone , wherein each channel is configured for two stage connection with a respective component , and the coupling device is configured for sterile interconnection of the flow channels of the plurality of components for passage of fluids therebetween.2. The coupling device of claim 1 , wherein:(a) the first stage is a sterilisation stage in which respective ones of the components are in sealing physical contact with the first coupling zone but not with the second coupling zone; and(b) the second stage is a coupling stage in which ones of the components are physically coupled with a respective one of the device channels at the sterilised second ...

CASSETTE SYSTEM INTEGRATED APPARATUS

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes. 18.-. (canceled)9. A fluid balancing cassette comprising:a first fluid flowpath and a separate, second fluid flowpath, each said first fluid flowpath and second fluid flowpath having a separate inlet to the cassette and a separate outlet from the cassette;a first fluid balancing pod having a fixed first total fluid volume and comprising a flexible membrane separating a first chamber from a second chamber, the sum of a first chamber volume plus a second chamber volume equal to the fixed first total fluid volume;the first chamber connected to the first fluid flowpath between a first fluid flowpath inlet valve and a first fluid flowpath outlet valve, and the second chamber connected to the second fluid flowpath between a second fluid flowpath inlet valve and a second fluid flowpath outlet valve;wherein said valves are pneumatically actuated membrane valves, and the first fluid flowpath inlet valve and the second fluid flowpath outlet valve are ganged together by being connected via a common actuation port or pneumatic line at a single pneumatic pressure to a pneumatic supply source able to controllably pressurize the common actuation port or pneumatic line to the single pneumatic pressure to actuate both the first fluid flowpath inlet valve and the second fluid flowpath outlet valve at the same time.101. The fluid balancing cassette of claim , further comprising a second fluid balancing pod having a fixed second total fluid volume and ...

Container and connector for providing a medical solution

A container for mixing an enclosed medical agent with a fluid. The container comprising an inclining bottom seam directed towards a connector. The connector comprising an elongated hollow body having a plurality of interconnected walls defining a first and a second longitudinal flow channel for fluidly connecting an inside and an outside of the container. The first flow channel has a first opening and a second opening, the first opening of the first flow channel is devised to be arranged inside of the container and the second opening of the first flow channel is devised to be arranged outside the container. The first opening of the first flow channel is arranged radially outwards from the first flow channel and directed towards said inclined bottom seam. The second flow channel has a first opening devised to be arranged inside of said container and a second opening devised to be arranged outside the container arranged axially to the first opening of the second flow channel.

FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES

A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session. 1. A portable dialysis cabinet , comprising:a dialysis system;at least two wheels disposed on a bottom surface of the dialysis cabinet;a first pair of opposing doors hingeably disposed on the dialysis cabinet creating when said doors are closed a first and second interior portions of the dialysis cabinet, the first pair of opposing doors having a first door connected to the dialysis cabinet by a first hinge on a front left side of the dialysis cabinet and a second door connected to the dialysis cabinet by a second hinge on a front right side of the dialysis cabinet, wherein the first door opens by swinging about a first vertical axis defined by a the first hinge on the left side of the dialysis cabinet and the second door opens by swinging about a second vertical axis defined by the second hinge on front right side of the dialysis cabinet; wherein the first door and second door are in contact when the first door and second door are closed; wherein the first and second interior portions are occupied by one or more interior components when closed; andat least one mounting surface for mounting a sorbent cartridge on a base of at least one of the first and second doors.2. The portable dialysis cabinet of claim 1 , further comprising at least a second mounting surface for mounting a reservoir on at least one of the first and second doors.3. The portable dialysis cabinet of claim 1 , wherein the first pair of opposing doors in an opened configuration provide access to one or more fluid connection ports located on a main body of the base ...

DIALYSIS SYSTEM

A dialysis system is disclosed. An example dialysis system includes a heat disinfected dialysate fluid path. The example dialysis system also includes a disposable blood fluid path. The example dialysis system also includes an active carbon filter to purify influent water to purified water for dialysis or as a substitution fluid. An example method for dialysis includes providing a heat disinfected dialysate fluid path, providing a disposable blood fluid path, and purifying influent water via an active carbon filter to for dialysis or as a substitution fluid. 1. A hemodialysis system , comprising:a heat disinfected dialysate fluid path;a disposable blood fluid path; andan active carbon filter to purify influent water to purified water for dialysis or as a substitution fluid.2. The hemodialysis system of claim 1 , further comprising a plurality of subsystems configured such that spent dialysate is filtered by active carbon filter and reused as dialysate for hemodialysis.3. The hemodialysis system of claim 1 , further comprising a plurality of subsystems configured as a single machine to purify the influent water by active carbon filter and hemodialysis treatment claim 1 , wherein the system provides heat disinfection of a dialysis machine with active carbon filter by the same component used for water purification.5. A water purification method for hemodialysis claim 1 , comprising:providing a heat disinfected dialysate fluid path;providing a disposable blood fluid path; andpurifying influent water via an active carbon filter for dialysis or as a substitution fluid.6. The water purification method of claim 5 , further comprising water purification modules sized with relation to the contaminant levels in the feed water.7. The water purification method of claim 5 , further comprising providing bagged water or dialysate solutions.8. The water purification method of claim 5 , further comprising determining the fluid flow rate from at least one bag.9. The water purification ...

SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL

Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end. 1. A system for performing any one of hemodialysis , hemodiafiltration , hemofiltration , comprising:a controlled compliant flow path comprising a dialyzer;at least a first pump in fluid communication with the controlled compliant flow path; a common reservoir in fluid communication with the first pump, wherein the common reservoir contains any one of a dialysate, a filtrate, a volume of a physiologically compatible priming solution, a volume of a physiologically compatible solution to provide a bolus of fluid to a subject receiving treatment, a volume of physiologically compatible solution to provide solution for return of blood from an extracorporeal flow path to a subject receiving treatment, a volume of solution returned to the common reservoir from an extracorporeal flow path when blood from a subject is introduced to the extracorporeal flow path, and combinations thereof;the at least first pump for selectively metering in and/or metering out fluid from the controlled compliant flow path; andthe at least first pump operable to control net fluid movement into and/or out of the controlled compliant flow path, wherein the at least first pump is operated by a controller applying an instantaneous rate of fluid removal to a control algorithm.2. The system of claim Error! Reference source not found. , wherein the controller applies the control algorithm to obtain a net volume of fluid added to and/or removed from a patient during therapy by an equation:{'br': None, 'sub': i=0', 'i, 'sup': 'n', 'i ...

RENAL FAILURE THERAPY MACHINES AND METHODS INCLUDING CONVECTIVE AND DIFFUSIVE CLEARANCE

A renal failure therapy machine includes a blood cleaning filter, a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter, a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance. 1. A renal failure therapy machine comprising:a blood cleaning filter;a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter;a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter; anda flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance.2. The renal failure therapy machine of claim 1 , which operates the flow restrictor to cause the regenerated therapy fluid to be pressurized so that at least ten percent of the regenerated therapy fluid performs convective clearance and at least a substantial amount of remaining regenerated therapy fluid performs diffusive clearance.3. The renal failure therapy machine of claim 1 , wherein the sorbent device includes a sorbent cartridge downstream from the blood cleaning filter claim 1 , the sorbent ...

ELECTRICAL PLUG FOR A DIALYSIS MACHINE

A dialysis machine comprising: a power supply for providing power to the dialysis machine, the power supply including a power supply cable that includes a first ground wire electrically connected to a first ground prong; and a hydraulics system for making dialysate, supplying the dialysate to a dialysate circuit, and draining spent dialysate from the dialysate circuit, the hydraulics system including a hydraulics grounding cable that includes a second ground wire electrically connected to a second ground prong. 121-. (canceled)22. A plug that is configured to plug into an AC power outlet , the plug comprising:a power supply cable that includes a first ground wire electrically connected to a first ground prong of the plug, the power supply cable for providing power to a dialysis machine; anda hydraulics grounding cable that includes a second ground wire electrically connected to a second ground prong of the plug, the hydraulics grounding cable for providing a grounding connection to a hydraulics system of the dialysis machine that is configured to make dialysate, supply the dialysate to a dialysate circuit of the dialysis machine, and drain spent dialysate from the dialysate circuit.23. The plug of claim 22 , wherein the first ground prong and the first ground wire are electrically isolated from the second ground prong and the second ground wire.24. The plug of claim 22 , wherein the first ground wire and the second ground wire do not share a common insulation.25. The plug of claim 22 , wherein an adapter is configured to:removably connect to and form an electrical connection with the power supply cable;removably connect to and form an electrical connection with the hydraulics grounding cable; andplug into the AC power outlet.26. The plug of claim 22 , further comprising a handle for facilitating simultaneous connection or disconnection of the power supply cable and the hydraulics grounding cable to or from the AC power outlet.27. The plug of claim 22 , wherein a ...

FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES

A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session. 1. A portable dialysis cabinet , comprising:a dialysis system; andat least two wheels disposed on a bottom surface of the dialysis cabinet.2. The portable dialysis cabinet of claim 1 , further comprising a handle disposed on the exterior portion of the dialysis cabinet.3. The portable dialysis cabinet of claim 2 , wherein the handle is a telescoping handle.4. The portable dialysis cabinet of claim 1 , further comprising at least one door hingeably disposed on the dialysis cabinet creating an interior portion of the dialysis cabinet and an exterior portion of the dialysis cabinet.5. The portable dialysis cabinet of claim 4 , wherein the at least one door comprises at least one shelf claim 4 , and the dialysis cabinet further comprises a user interface module attached to the dialysis cabinet and in electronic communication with a control module.6. The portable dialysis cabinet of claim 5 , wherein the user interface comprises one or more of a keyboard claim 5 , a touch screen claim 5 , a display screen claim 5 , a mouse claim 5 , a microphone claim 5 , and a speaker.7. The portable dialysis cabinet of claim 5 , wherein the user interface is a stowable user interface claim 5 , and wherein the dialysis cabinet comprises a recess into which the user interface can be stowed.8. The portable dialysis cabinet of claim 1 , further comprising one or more fluid connection ports on the interior portion of the dialysis cabinet.9. The portable dialysis cabinet of wherein the shelf comprises at least one mounting surface.10. The portable dialysis ...

DIALYSIS MACHINE AND METHOD OF OPERATING A DIALYSIS MACHINE

The present invention relates to a dialysis machine that is configured to be equipped with an extracorporeal blood system comprising a dialysis solution system that is configured to be equipped with a dialyzer, wherein a mixing region, in particular a mixing chamber, is provided in which the fresh dialysis solution or a component thereof is located in the operation of the dialysis machine, with a concentrate line being in fluid communication with the mixing region, through which concentrate line concentrate can be conducted from a concentrate container into the mixing region, wherein at least two electrically conductive elements are arranged spaced apart from one another in or at the concentrate line or lines; that a measuring device is provided which is electrically connected to the conductive elements and which is configured to measure the conductance or a value correlated therewith between them; and that a control unit is provided which is configured to compare the measured value with a desired value, with a limit value, or with a desired value range. 1. A dialysis machine that is configured to be equipped with an extracorporeal blood system comprising a dialysis solution system that is configured to be equipped with a dialyzer , wherein a mixing region , in particular a mixing chamber , is provided in which the fresh dialysis solution or a component thereof is located in the operation of the dialysis machine , with a concentrate line being in fluid communication with the mixing region , through which concentrate line concentrate can be conducted from a concentrate container into the mixing region ,characterized in thatat least two electrically conductive elements are arranged spaced apart from one another in or at the concentrate line or lines; that a measuring device is provided which is electrically connected to the conductive elements and which is configured to measure the conductance or a value correlated therewith between them; and that a control unit is ...

Blood Treatment Systems

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures. 1. A blood treatment machine comprising:a treatment module including a structure for releasably coupling with a dialyzer;a blood treatment machine console that controls the treatment module; and 'wherein the treatment module is mounted to an arm extending from the blood treatment machine console.', 'one or more sensors operable to determine an orientation or motion of the blood treatment module in relation to the blood treatment machine console,'}2. The blood treatment machine of claim 1 , wherein the treatment module is cantilevered from the arm.3. The blood treatment machine of claim 2 , wherein the arm includes one or more adjustable joints by which the arm can be manually articulated into multiple differing positions relative to the blood treatment machine console.4. The blood treatment machine of claim 2 , wherein the blood treatment machine console comprises facilities for making dialysate.5. The blood treatment machine of claim 2 , wherein the treatment module comprises a drive unit that generates dynamic magnetic fields to levitate and rotate a pump rotor contained within the dialyzer while the dialyzer is coupled with the treatment module.6. The blood treatment machine of claim 2 , wherein the treatment module comprises:a first pressure transducer positioned to abut against a first membrane of a first pressure detection chamber of the ...

Device For Extracorporeal Blood Treatment And Method For Operating An Extracorporeal Blood Treatment Device

The invention relates to a device for extracorporeal blood treatment, having a hydraulic system B which comprises multiple lines (), () for providing dialysate for a dialyser () and having a control system () which comprises multiple electrical components (A), (B), (C). The invention also relates to a method for operating a device for extracorporeal blood treatment which has a hydraulic system which comprises multiple lines for providing dialysate for a dialyser and a control system which comprises multiple electrical components, wherein the dialysate is produced using a liquid supplied to the device for extracorporeal blood treatment. The extracorporeal blood treatment device is a blood treatment device which has a central connection () to allow a liquid, in particular permeate (pure water), to be supplied to the machine. The blood treatment device is characterised by a cooling apparatus () for cooling at least one of the electrical components (A), (B), (C) of the control system (), said cooling apparatus using the liquid, in particular permeate (pure water), supplied centrally to the device to dissipate heat from the electrical components. The cooling apparatus () has at least one heat sink () which can be cooled with a liquid and is in thermal contact with the at least one electrical component (A), (B), (C), wherein the cooling apparatus () has at least one inlet (A) which is fluid-connected to the connection () for the inflow of a liquid and at least one outlet (B) which is fluid-connected to a drain (), (). 1. Device for extracorporeal blood treatment , comprising a hydraulic system that has a plurality of lines and is intended for providing dialysate for a dialysis treatment , and a control system comprising at least one electrical component , the hydraulic system having at least one port for supplying a fluid to the device for extracorporeal blood treatment ,whereinthe device for extracorporeal blood treatment has a cooling apparatus for cooling the ...

PUMPING CASSETTE

A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet. 1. A pumping cassette comprising:a housing comprising at least two inlet fluid lines and at least two outlet fluid lines;at least one balancing pod within said housing and in fluid connection with said fluid paths, whereby said balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of said first fluid equals the volume of said second fluid and wherein said balancing pod comprising a membrane wherein said membrane forming two balancing chambers; andat least one reciprocating pressure displacement membrane pumps within said housing wherein said pressure pump pumps said fluid from a fluid inlet to a fluid outlet line and said second fluid from a fluid inlet to a fluid outlet.2. The cassette claimed in wherein said reciprocating pressure displacement pumps comprising:a curved rigid chamber wall; anda flexible membrane attached to said rigid chamber wall, whereby said flexible membrane and said rigid chamber wall define a pumping chamber.3. The cassette claimed in wherein said housing further comprising:a top plate;a midplate; anda bottom plate.4. The cassette claimed in further comprising a metering pump within said housing and fluidly connected to a fluid line claim 1 , wherein said metering pump pumps a volume of a fluid.5. The ...

Ultra-Pasteurization For Dialysis Machines

Disclosed herein are water purification and supply systems for medical devices and methods of using. In an embodiment, the system includes A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream. 1. A water purification and supply system for a medical device , the system comprising;a reverse-osmosis filter with a water inlet, a filtered water outlet, and a filter waste water outlet;a pump in fluid communication with and downstream from the filtered water outlet;a first heat exchanger having a filtered water inlet, a filtered water outlet, a waste water inlet and a waste water outlet, the filtered water inlet in fluid communication with and downstream from the pump, the waste water outlet in fluid communication with a drain;a heater in fluid communication with and downstream from the filtered water outlet of the first heat exchanger;a second heat exchanger having a filtered water inlet, a filtered water outlet, a waste water inlet, and a waste water outlet, the filtered water inlet in fluid communication with and downstream from the heater, the waste water inlet of the first heat exchanger in fluid communication with and downstream from the waste water outlet of the second heat exchanger;a throttle valve in fluid communication with and downstream from the filtered water outlet of the second heat exchanger; anda proportioning valve having a valve inlet, a first valve outlet and a second valve outlet, the valve inlet in communication with and downstream from the filter waste water outlet, the second valve outlet in communication with the drain, the first valve ...

DIALYSIS SYSTEM

A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream. 1. A dialysis system , comprising: a fluid pathway having a water inlet and a water outlet, the fluid pathway further comprising', 'a first region where water flows in a first direction at a first temperature;', 'a heater region downstream of the first region, the water flowing into the heater region at the first temperature and the heater region comprising at least one heater that transfers heat into the water flowing through the heater region to increase the temperature to a second temperature greater than the first temperature; and', 'a second region downstream of the heater region where water flows in a second direction at a temperature greater than the first temperature, wherein water flowing in the second region thermally communicates with water flowing in the first region such that heat transfers from water flowing in the second region to water flowing in the first region resulting in a temperature reduction in the water as it flows through the second region, wherein water flows out of the fluid pathway through the water outlet at a temperature less than the second temperature;, 'a water purification system comprising a microfluidic channel, flow field, or both, the water purification system capable of processing a household water stream in a non-batch process to produce a pasteurized water stream, the water purification system comprising a heat exchange system comprising'}a dialysate preparation system capable of mixing the pasteurized water stream with dialysate components to produce a ...

ELECTROKINETIC ROUTE TO A WEARABLE DEVICE FOR KIDNEY DISEASE MANAGEMENT

A portable device for removal of metabolic waste from the blood of patient having kidney disease or in need of hemodialysis is provided. Methods of hemodialysis employing the portable device beneficially obtain a dialysate by electrokinetic means from excess fluid in the peripheral blood of the patient in need thereof. The methods employ a branched microfluidic channel for the use of ion concentration polarization to separate charged from neutral species in blood to obtain the dialysate for undergoing hemodialysis. Beneficially the methods and device are resistant to biofouling, remove the need for a dialysate and/or dialysate reservoir, and provide a disposable, wearable device. 1. A method for hemodialysis comprising:removing neutral compounds from blood plasma of a subject in need of hemodialysis by ion concentration polarization;obtaining fluid from the blood plasma containing the neutral compounds to source as a subject-derived dialysate; andusing the dialysate to accept metabolic waste during hemodialysis.2. The method of claim 1 , wherein the neutral compounds comprise water and small neutral molecules claim 1 , and wherein the removal of neutral compounds by ion concentration polarization generates two streams from the blood plasma and is applied to the blood plasma at a rate of about 0.01 to about 50 mL/minute.3. The method of claim 2 , wherein the first stream is a charged stream that is recombined with cell containing fraction of the subject's blood claim 2 , and wherein the second stream is a neutral stream comprising the fluid of the subject-derived dialysate.4. The method of claim 1 , wherein the ion concentration polarization takes place in a branched microchannel of a device comprising a membrane.5. The method of claim 4 , wherein the device is a branched claim 4 , flow-through microfluidic device claim 4 , and wherein the membrane is a nanoporous membrane with fixed charges along a pore surface.6. The method of claim 1 , further comprising flowing a ...

MIXING FOR ONLINE MEDICAL FLUID GENERATION

A dialysis system includes: (i) a source of water made suitable for a dialysis treatment; (ii) at least one concentrate for mixing with the water from the source; (iii) a dialysis fluid pump; and (iv) a disposable set operable with the dialysis fluid pump and in fluid communication with the source of water and the at least one concentrate, the disposable set including a container having a first end and a second end, the container configured to allow the water and the at least one concentrate pumped by the dialysis fluid pump to enter at the second end and exit from the first end to mix for the dialysis treatment. 1. A dialysis system comprising:a source of water made suitable for a dialysis treatment;at least one concentrate for mixing with the water from the source;a dialysis fluid pump; anda disposable set operable with the dialysis fluid pump and in fluid communication with the source of water and the at least one concentrate, the disposable set including a container having a first end and a second end, the container configured to allow the water and the at least one concentrate pumped by the dialysis fluid pump to enter at the second end and exit from the first end to mix for the dialysis treatment.2. The dialysis system of claim 1 , which is configured such that the water and the at least one concentrate pumped by the dialysis fluid pump enter the container partially mixed together.3. The dialysis system of claim 1 , wherein the container is a flexible bag.4. The dialysis system of claim 1 , wherein the disposable set includes a pumping cassette that interfaces with the dialysis fluid pump.5. The dialysis system of claim 4 , wherein the water and the at least one concentrate are mixed initially in the pumping cassette.6. The dialysis system of claim 4 , wherein the dialysis fluid pump pneumatically actuates the pumping cassette.7. The dialysis system of claim 4 , wherein the disposable set includes a tube extending from the pumping cassette to the container.8. ...

DIALYSIS MACHINE AND CONSTANT FLOW REGULATOR

The invention relates to a dialysis machine, in particular for hemodialysis and/or hemofiltration, having a dialyzate system and having a water inlet via which the dialyzate system can be connected to an external water supply, characterized in that a constant flow regulator is arranged between the water connection and the dialyzate system. 1. A dialysis machine , in particular for hemodialysis and/or hemofiltration , having a dialyzate system and having a water inlet via which the dialyzate system can be connected to an external water supply ,characterized in thata constant flow regulator is provided between the water connection and the dialysate system.2. A dialysis machine in accordance with claim 1 , wherein the constant flow regulator is arranged between the water inlet and a water inlet chamber of the dialyzate system claim 1 , with the water inlet chamber preferably having a level detection and/or an inlet valve claim 1 , with a control of the dialysis machine preferably controlling the inlet valve in dependence on the level detection.3. A dialysis machine in accordance with claim 1 , wherein the constant flow regulator is configured as a passive flow control element; and/or wherein a constant flow regulator in accordance with one of the following claims is used as the constant flow regulator.4. A constant flow regulator claim 1 , in particular for a dialysis machine in accordance with claim 1 , comprisinga housing which is flowed through by fluid and which has an inlet, a regulator opening and an outlet;a plunger which is displaceably arranged in the housing, with a regulator passage remaining between the regulator opening and the plunger which is dependent on the relative position between the plunger and the regulator opening and which defines the regulation effect; anda spring against whose force the plunger is displaced by a differential pressure between the inlet and the outlet of the housing,characterized in thatthe minimum flowed-through cross-section ...

SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION

A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance. 1. A regeneration system , comprising:a first regeneration module containing a first chosen regenerative substance;a second regeneration module containing the first chosen regenerative substance; anda first mixing chamber, wherein a first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.2. The regeneration system of claim 1 , wherein a first inlet stream of the fluid that enters the first mixing chamber is mixed in the first mixing chamber with a second inlet stream of the fluid that enters the first mixing chamber.3. The regeneration system of claim 2 , wherein the first mixing chamber further comprises a static mixer element.4. The regeneration system of claim 2 , wherein the mixing chamber further comprises a semi-permeable membrane that separates the first inlet stream from the second inlet stream claim 2 , and a solute diffuses from the first inlet stream to the second inlet stream.5. The regeneration system of claim 2 , wherein the second inlet stream ...

FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES

A flow loop for hemodialysis, hemodiafiltration and hemofiltration for the treatment of pathological conditions such as End Stage Renal Disease (ESRD) that has a controlled compliant flow path for preparing fluids required for a hemodialysis therapy session from water. The controlled compliant flow path modifies water into any one of a solution for priming a hemodialysis system, a physiologically compatible solution for contacting blood, a physiologically compatible solution for infusion to a subject, and a solution for blood rinse back to a subject. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the flow path. 1. A flow loop for hemodialysis , comprising:a controlled compliant flow path for preparing fluids required for a hemodialysis therapy session from water wherein the controlled compliant flow path modifies water into any one of a solution for priming a hemodialysis system, a physiologically compatible solution for contacting blood, a physiologically compatible solution for infusion to a subject, and a solution for blood rinse back to a subject;said controlled compliant flow path having a means for selectively metering in and metering out fluid from the flow path.2. The flow loop for hemodialysis of claim 1 , wherein the means for selectively metering in and metering out fluid from the controlled compliant flow path is a fluid balance control pump in fluid communication with the controlled compliant flow path and a reservoir.3. The flow loop for hemodialysis of claim 1 , wherein the controlled compliant flow path has a first pump for circulating a dialysate from a dialysate outlet of the dialyzer to a dialysate inlet of the dialyzer claim 1 , a one-way valve allowing only solution efflux from the dialyzer outlet claim 1 , a solution regeneration system with at least one port for solution influx and at least one port for efflux of a solution claim 1 , a second pump in fluid communication with the ...

SODIUM AND BUFFER SOURCE CARTRIDGES FOR USE IN A MODULAR CONTROLLED COMPLIANT FLOW PATH

Systems and methods for using a sodium chloride source and a buffer source such as sodium bicarbonate in a controlled compliant flow path to generate from water a physiologically compatible fluid having a suitable level of a sodium ion and/or a buffer for use in hemodialysis, hemodiafiltration and hemofiltration. The system has a conditioning flow path that has at least a salination valve or salination pump, and at least one container has at least one solute in excess of the solubility of that solute. At least one of the solutes is a buffer source or sodium chloride. The conditioning flow path is in fluid communication with a controlled compliant flow path. The conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path. 1. A system for generating a physiologically compatible fluid , comprising:a conditioning flow path having at least a salination valve or salination pump, and at least one container having at least one solute in excess of the solubility of that solute wherein at least one of the solutes is a buffer source or sodium chloride;said conditioning flow path in fluid communication with a controlled compliant flow path wherein the conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path.2. The system of claim 1 , wherein the controlled compliant flow path modifies water into any one of a solution for priming an extracorporeal circuit claim 1 , rinsing or flushing a dialyzer and blood flow conduits claim 1 , a physiologically compatible solution for contacting blood claim 1 , a physiologically compatible solution for bolus infusion to a subject claim 1 , and a solution for blood rinse back to a subject.3. The system of claim 1 , wherein selectively metering in and metering out fluid from the controlled compliant flow path generates a physiologically compatible level of a sodium ion and/or a buffer from the at least one container in the conditioning flow path.4. The system ...

CALIBRATION METHOD FOR FLOWMETERS IN BLOOD DIALYSIS SYSTEM

Provided is a calibration method for flowmeters in a blood dialysis system, whereby highly accurate calibration can be performed even by omitting a reference flowmeter not directly relating to dialysis therapy. This calibration method comprises: while preventing outflow into a blood channel in a blood purifier, supplying a liquid to a channel, said channel passing through an inflow flowmeter and an outflow flowmeter; and then calibrating the inflow flowmeter and the outflow flowmeter correction whereby, at the time of liquid supply, a value measured by the outflow flowmeter is equalized to a value measured by inflow flowmeter. 1. A calibration method for flowmeters in a blood dialysis system , the blood dialysis system comprising:a blood purifier comprising a dialysis membrane, dialysate and blood being supplied to the blood purifier to undergo substance exchange therebetween, via the dialysis membrane;a liquid feeding pump configured to supply the dialysate to the blood purifier;a liquid discharging pump configured to discharge the dialysate from the blood purifier;an inflow flowmeter configured to measure a quantity of flow of the dialysate to be supplied to the blood purifier;an outflow flowmeter configured to measure a quantity of flow of the dialysate to be discharged from the blood purifier; anda calculation unit configured to measure a quantity of fluid removal from the blood based on a difference in measurements between the inflow flowmeter and the outflow flowmeter,the calibration method comprising:supplying liquid to a flow channel passing through the inflow flowmeter and the outflow flowmeter while preventing outflow of the liquid to a blood flow channel in the blood purifier; andperforming correction to match the measurements of the outflow flowmeter obtained when the liquid is supplied with the measurements of the inflow flowmeter, thereby calibrating the inflow flowmeter and the outflow flowmeter.2. A calibration method for flowmeters in a blood ...

Fluid processing apparatus

A machine is provided with a slot to releasably receive and retain a cartridge in which dialysis is effected. The machine is configured for supplying to the cartridge, at a controlled temperature and rate, sterile water for use in haemodialysis and is operable to maintain, in a sterile condition, residual water contained therein after completion of a haemodialysis treatment.

pH BUFFER MEASUREMENT SYSTEM FOR HEMODIALYSIS SYSTEMS

A pH-buffer measurement system that has at least one source for modifying the pH of a fluid entering the system, the source selected from an acid source and a base source. The acid source adds an acid equivalent to provide an acid reacted fluid and the base source adds a base equivalent to provide a base reacted fluid. The source is in fluid communication with a flow path and a component for determining a fluid characteristic of the acid reacted fluid or the base reacted fluid. The fluid characteristic that is measured is any one of a gas phase pressure, an electrical conductivity, or thermal conductivity. 1. A pH-buffer measurement system , comprising:at least one source for modifying the pH of a fluid entering the system, the source selected from an acid source and a base source wherein the acid source adds an acid equivalent to provide an acid reacted fluid and the base source adds a base equivalent to provide a base reacted fluid wherein the source is in fluid communication with a flow path; anda component for determining a fluid characteristic of the acid reacted fluid or the base reacted fluid; wherein the fluid characteristic that is measured is any one of a gas phase pressure, an electrical conductivity, or thermal conductivity.2. The system of claim 1 , wherein the component determines a fluid characteristic of an unreacted fluid.3. The system of claim 1 , further comprising a static mixer downstream from the at least one source for modifying the pH of the fluid entering the system.4. The system of claim 1 , further comprising one or more pumps for pumping fluid into and out of the system.5. The system of claim 1 , wherein the system determines a pH claim 1 , buffer content or both of the fluid by taking a difference between a first value of the fluid characteristic of the fluid entering the system and a second value of the fluid characteristic of the acid reacted fluid or the base reacted fluid.6. The system of claim 1 , wherein the system determines a pH ...

SODIUM AND BICARBONATE CONTROL SYSTEM

The invention relates to systems and methods for performing dialysis with closed-loop control of sodium and bicarbonate concentrations in the dialysate. The system and methods can use one or more conductivity sensors in a dialysate flow path to determine a water addition rate and a bicarbonate addition rate resulting in a dialysate having desired sodium and bicarbonate concentrations. 1. A sodium and bicarbonate control system , comprising:a first conductivity sensor in a dialysate flow path; the first conductivity sensor positioned downstream of a dialyzer and upstream of a sorbent cartridge containing urease;a water source fluidly connected to the dialysate flow path downstream of the first conductivity sensor;a bicarbonate source fluidly connected to the dialysate flow path downstream of the sorbent cartridge;a second conductivity sensor in the dialysate flow path; the second conductivity sensor positioned downstream of the bicarbonate source; anda processor programmed to set a water addition rate; the water addition rate set based on a sodium prescription and a conductivity measured by the first conductivity sensor; the processor further programmed to set a post-bicarbonate conductivity set point based on the sodium prescription and a bicarbonate prescription; the processor further programmed to control a bicarbonate addition rate to achieve the post-bicarbonate conductivity set point as measured by the second conductivity sensor.2. The sodium and bicarbonate control system of claim 1 , wherein the water source is upstream of the sorbent cartridge.3. The sodium and bicarbonate control system of claim 1 , wherein the water source is downstream of the sorbent cartridge.4. The sodium and bicarbonate control system of claim 1 , wherein the water source is upstream of the bicarbonate source.5. The sodium and bicarbonate control system of claim 1 , wherein the water source is downstream of the bicarbonate source.6. The sodium and bicarbonate control system of claim 1 ...

Extracorporeal blood treatment apparatus

An extracorporeal blood treatment apparatus is provided comprising a filtration unit ( 2 ) connected to a blood circuit ( 17 ) and to a dialysate circuit ( 32 ), a preparation device ( 9 ) for preparing and regulating the composition of the dialysis fluid; a control unit ( 12 ) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line ( 8 ) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

METHOD AND APPARATUS FOR PREPARING A MEDICAL SOLUTION

The present invention relates to a method for preparing a medical solution from at least one first liquid component and at least one second liquid component, wherein the first component and the second component are conveyed with a respective conveying means to obtain a mixed solution, wherein the conveying means are operated such that a modulation of the concentration of the first and second components takes place and the conductivity or a parameter of the mixed solution correlating with the conductivity is measured at a measurement point, wherein the modulation of the concentrations takes place in a desired state such that no modulation or a specific desired modulation of the measured conductivity or of the parameter correlated with the conductivity occurs. The present invention furthermore relates to an apparatus for preparing a medical solution as well as to a blood treatment device having such an apparatus. 1. A method for preparing a medical solution from at least one first component and at least one second component , wherein the first component and the second component are present as liquids and are conveyed by a respective conveying means to obtain a mixed solution , characterized in that the conveying means are operated such that a modulation of the concentrations of the first and second components takes place and the conductivity or a parameter of the mixed solution correlating with the conductivity is measured at a measurement point , wherein the modulation of the concentrations of the components takes place in a desired state such that a specific desired modulation or no modulation of the measured conductivity or of the parameter of the mixed solution correlated with the conductivity occurs.2. A method in accordance with claim 1 , characterized in that an evaluation of the measured conductivity or of the measured value of the parameter of the mixed solution correlated with the conductivity is carried out and a conclusion is drawn on an error state on an ...

APPARATUS AND PROCESS FOR PREPARATION OF SMALL WATER CLUSTER AND SMALL MOLECULAR CLUSTER WATER PREPARED THEREFROM

The invention provides an apparatus of treating water to obtain small water cluster, which comprises one or more illumination devices and one or more holders holding metal particles. The invention also provides a method of preparing the small water cluster and the small water cluster prepared from the apparatus or the method. 1. A water treatment apparatus for preparing small water cluster , comprising one or more illumination devices and one or more holders holding metal particles capable of surface plasma resonance , provided that the holder allows illumination of the metal particles.2. The apparatus of claim 1 , wherein the holder is a transparent hollow column or hollow container having one or more inlets and one or more outlets and optionally the one or more outlets have a switching control valve claim 1 , wherein the transparent hollow column or hollow container fills with metal particles capable of surface plasma resonance.3. The apparatus of claim 2 , wherein the outlet of the column is narrower than the inlet of the column.4. The apparatus of claim 1 , wherein the illumination device is a light source providing a wavelength ranging from 100 nm to 3 claim 1 ,000 nm.5. The apparatus of claim 1 , wherein the illumination device is a daylight lamp claim 1 , LED lamp claim 1 , lamp bulb claim 1 , mercury lamp claim 1 , metal halide lamp claim 1 , sodium lamp or halogen lamp.6. The apparatus of claim 5 , wherein the LED lamp is an LED green lamp.7. The apparatus of claim 1 , wherein the metal particle is a nano-gold particle claim 1 , a nano-silver particle claim 1 , a nano-platinum particle claim 1 , a nano-rhodium particle claim 1 , a nano-copper particle claim 1 , a nano-nickel particle claim 1 , a nano-zirconium particle claim 1 , a nano-alloy particle claim 1 , a nano-TiOparticle claim 1 , a nano-gold/silver particle claim 1 , a nano-gold/TiOparticle claim 1 , or a combination thereof.8. The apparatus of claim 1 , wherein the metal particle is a nano-gold ...