СПОСОБЫ И СИСТЕМЫ ДЛЯ УДАЛЕНИЯ ДВУОКИСИ УГЛЕРОДА

Группа изобретений относится к медицине, а именно к способу удаления катионов водорода (H+) из биологической текучей среды в диализной системе, способу экстракорпоральной обработки крови субъекта – человека или животного в диализной системе, а также к способу лечения субъекта, страдающего нарушением кислотно-щелочного баланса. Способы включают воздействие на биологическую текучую среду через полупроницаемую мембрану диализной текучей среды в диализаторе, в котором диализная текучая среда включает (I) значение pH, находящееся в диапазоне от 8,0 до 11,0, (II) по меньшей мере один буферный агент, имеющий значение pKa в диапазоне от 7,0 до 11,0 и (III) буферную емкость, составляющую для ионов H+ по меньшей мере 12 ммоль/л, в котором способ дополнительно включает автоматическое определение количества катионов водорода (H+), удаленных из биологической текучей среды, в котором количество катионов водорода (H+), удаленных из биологической текучей среды, рассчитывают на основе буферной емкости диализной ...

УСТРОЙСТВО ДЛЯ ОБРАБОТКИ КРОВИ, ОЗОНОВЫЙ ГЕНЕРАТОР ДЛЯ ПРОИЗВОДСТВА ОЗОНА, УСТРОЙСТВО ДЛЯ КОНТАКТА ГАЗА И ЖИДКОСТИ, СПОСОБ ИНАКТИВАЦИИ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА В БЕЛКОВОМ МАТЕРИАЛЕ

Предложены устройство и способ для инактивации инфекционных организмов, таких, как вирусы, бактерии, грибы и простейшие, и, в частности, для инактивации вируса иммунодефицита человека, в белковом материале, таком, как кровь и продукты крови, без неблагоприятного воздействия на нормальную физиологическую активность этого материала путем контактирования его в течение временного интервала, приблизительно 16 с, с озон-кислородной смесью, имеющей концентрацию озона всего лишь приблизительно 27 мкг/мл. Устройство содержит устройство для контакта газа и жидкости, через которое материал и озон-кислородная смесь текут в контактирующем противотоке, и генератор озона, продуцирующий озон-кислородную смесь, имеющую резонансную частоту приблизительно 7,83 Гц. Эти устройство и способ обеспечивают точный контроль концентрации озона и времени контакта между подлежащим обработке материалом и озон-кислородной смесью.

СИСТЕМА И СПОСОБ ПОВЫШЕНИЯ НАРУЖНОГО ДИАМЕТРА ВЕН И АРТЕРИЙ

EINRICHTUNG UND VERFAHREN ZUR OXYGENATION EINES AUFGELOESTEN, SAUERSTOFF UEBERTRAGENDEN STOFFGEMISCHES IM FLUESSIGEN ZUSTAND.

Vorrichtung zur Insufflation von Gasen bzw. fluessigen Medikamenten

VORRICHTUNG ZUR SAUERSTOFFANREICHERUNG VON BLUT

Geraet fuer ausserkoerperliche Blutzirkulation

BEHANDLUNG VON STRESS UND VORBEHANDLUNG GEGEN STRESS

EXTRACORPOREAL BLOOD OXYGENATOR AND BLOOD TEMPERATURE CONTROLLER

... 1419551 Blood oxygenating and temperature controlling device R C BRUMFIELD 28 March 1973 [31 March 1972] 14911/73 Heading A5R [Also in Division B1] An extra-corporeal blood oxygenator and blood temperature controlling device, suitable for exchanging oxygen for carbon dioxide in a patient's circulating blood, comprises small diameter oxygenator tubes 11, Fig. 1, having equal lengths, disposed in a parallel array between a base header plate 17 and a top header plate 18, the header plates being fluid impervious and securing the tubes; a boundary case 19 enclosing a space through which the tubes 11 extend; two conduits 21, 22 for leading heat transfer fluid into and out of the case 19; the oxygenator tubes 11 serving for carrying a twophase mixture of blood and oxygen plus carbon dioxide gas, the tubes 11, header plates 17, 18 and case 19 forming a heat exchanger for transferring heat between the heat transfer fluid and the mixture. The heat transfer fluid enters by conduit 21, flows to the ...

PRESERVATION OF ORGANS

... 1314279 Organ perfusion apparatus BAXTER LABORATORIES INC 5 Oct 1970 [6 Oct 1969] 47190/70 Heading A2D An organ perfusion apparatus comprises a container for the organ, a circuit including the container for passing perfusate through the container, a pressure means for delivering the perfusate in a pulsatile manner to the container and means for maintaining between pressure pulses a pressure lower than the pressure on the perfusate in the container, oxygenating means in the circuit for oxygenating perfusate conducted from the organ and control means for determining the output of the pressure means, and including means for setting the period of each high pressure pulse. A suitable apparatus is shown in Fig. 1 wherein a pneumatic source 22 which preferably uses compressed oxygen communicates with a control unit 26 which pulses the oxygen and passes this gas to pump 40. Perfusate such as whole blood communicates with a simulated aorta 44 with each high pressure pulse through the line 38. Pressure ...

DEVICE FOR THE SUPPLY A EXTRAKORPORALEN OF A BLUTKREISLAUFS

PROCEDURE AND DEVICE FOR THE DETECTION OF BLISTERS IN A LIQUID

SYSTEM FOR THE OXYGENATION OF THE HEART USING APPROXIMATELY PERIKARDIALEN LIQUIDS

EQUIPMENT TO THE MEDICAL OZONE THERAPY THROUGH TRANSFUSION OR INFUSION.

MECHANISM AND PROCEDURE FOR OXYGENATION A DISSOLVING, OXYGEN UEBERTRAGENDEN OF MATERIAL MIXTURE IN THE LIQUID CONDITION.

BOTTLE FOR THE OZONIZATION OF BLOOD FOR THE SELF-BLOOD THERAPY, OF BLOOD PLASMA OR PLASMA PARLIAMENTARY GROUPS.

DEVICE FOR THE TRANSMISSION OF ONE OR MORE SUBSTANCES BETWEEN A GAS AND A LIQUID.

METHOD, A GAS-SURFEITED LIQUID TO A GAS-POOR PLACE TO LEADING AND YOUR APPLICATION

DEVICE TO BLUTOXYGENIERUNG

SYRINGE

Cylindrical rotary Oxygenator

PROCEDURE FOR THE INCREASE THE NITROGEN OXIDE CONCENTRATION IN THE BLOOD

USE OF THE MODIFIED OWN BLOOD FOR THE TREATMENT OF AUTOCIMMUNE ILLNESSES

PUTTING POINT FOR USE IN A DEVICE FOR THE TREATMENT OF BLOOD

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

BLOOD OXYGENATOR

Photolytic cell for providing physiological gas exchange

Gas treatment delivery systems and methods

The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.

Method of increasing the concentration of nitric oxide in blood

PRESERVATION OR ORGANS

BLOOD OXYGENATOR HEAT EXCHANGER

PHOTOLYTIC CELL FOR PROVIDING PHYSIOLOGICAL GAS EXCHANGE

The present invention is directed to a photolytic cell (16), and to a photolytic artificial lung (10) incorporating such a cell (16). The photolytic artificial lung (10) converts water to oxygen for blood absorption, regulates pH, removes carbon dioxide, and co-produces electrical power. The photolytic artificial lung (10) includes a photolytic cell (16) where all of the chemical reactions occur. Additionally, the present invention relates to photolytically sensitive materials for oxygen generation. These materials are useful for gas- free artificial lung fabrication. The photolytic cell (16) disclosed herein can also be used to direct chemical reactions in organs other than the lung. It can also be used to maintain breathing air in confined systems.

APPARATUS AND METHOD FOR CONTROLLING FLUID FLOW

Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.

BLOOD OXYGENATING DEVICE

METHOD AND APPARATUS FOR PERITONEAL HYPOTHERMIA AND/OR RESUSCITATION

Embodiments of the invention provide apparatus, systems and methods for introducing fluids into a body cavity for hypothermic and resuscitative treatment. One embodiment provides an apparatus for introducing fluids into a peritoneal cavity comprising an access device for insertion into subcutaneous tissue, an infusion member and an advancement member. The access device includes a lumen, a proximal end, a tissue penetrating distal end and a stop for controlling the depth of the distal end into tissue. The infusion member includes an infusion lumen, a removal lumen and at least one sensor and is advanceable from a lumen of the access device into the peritoneal cavity. The advancement member is removably positionable in an infusion member lumen and has sufficient column strength to advance the infusion member tip through abdominal wall tissue into the peritoneal cavity. When the advancement member is removed, the infusion member tip is substantially atraumatic.

TREATMENT OF AUTOIMMUNE DISEASES

An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia , leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.

Vorrichtung zur Behandlung von venösem Blut.

Gerät zur Behandlung von Blut mit Sauerstoff

Vorrichtung zur Behandlung von Blut mit Sauerstoff und ultraviolettem Licht

Tragbare Einrichtung zur Behandlung von Blut

Poumon artificiel pour le traitement du sang d'un patient

Gerät zur Behandlung von Blut, Blutplasma oder dergleichen mit einem Gas

Vorrichtung zur Behandlung von Blut mit Sauerstoff und ultraviolettem Licht

Oxygenerator für Geräte für die künstliche Aufrechterhaltung des Blutkreislaufes

Verfahren zum Beladen von Blut mit Sauerstoff und Einrichtung zur Durchführung des Verfahrens

Gerät für ausserkörperliche Blutzirkulation

Vorrichtung zum Anreichern von Sauerstoff im Blut

BUBBLE BLOOD OXYGENATOR.

APPARATUS FOR THE OXYGENISATION OF BLOOD.

TREATMENT STRESS AND PRELIMINARY FORMATION OF CONDITIONAL REFLEXES AGAINST STRESS

APPARATUS FOR the OXYGENATION OF BLOOD

Device for the continuous and discontinuous extracorporal oxygenation of blood

Incubateur pour vaccine personnalisee, injectable a temperature du corps, en partant du sang du patient, traite hors de son corps, pour eviter tout rejet

Incubateur pour vaccine personnalisee, injectable a temperature du corps, partant de son sang gueri hors du corps du patient, evitant tout rejet. L'incubateur, est un autoclave, fonctionnant en parallele avec un generateur de vaccine, qui prepare le sang du malade a la guerison. Cette operation terminee, l'incubateur, qui a produit de l'eau distillee ionisee selon la methode Lavinay (inscrite au Vidal) recoit cette vaccine qui sera portee a la plus haute temperature pour la destruction des virus et microbes et la naissance des anticorps, devant agir sur le milieu. Le patient ne peut en aucune maniere atteindre de telles temperatures. Tout cet ensemble est parti du sang du patient evitant ainsi tout rejet.

BLOOD OXYGENATORS

Apparatus for the treatment of blood or others liquid organics

SYSTEMS, KITS, AND METHODS OF ADMINISTERING SYNTHETIC PLASMA

Improved methods of administering a synthetic plasma-like solution to a subject, as well as systems and kits for practicing the same, are provided by the subject invention. In the subject methods, the CO2 level of the subject, particularly the CO2 level of at least one of the blood and brain of the subject, is reduced prior to administration of the synthetic plasma-like solution. The subject methods find use in a variety of applications where synthetic plasma-like solutions are employed, including the treatment of hypovolemia, hyphemia, and surgical procedures in which at least a portion of a subject's blood is replaced with a synthetic plasma-like solution and provide for a number of improvements, including a reduced risk of acidosis/acidemia and complications associated therewith.

METHOD AND CATHETER FOR AERATING FLUIDS FOR MEDICAL USES

A gas (23) such as air or oxygen is forced into an aqueous fluid such as blood, plasma, blood extender fluids, or an imaging medium to form very small microbubbles (31) on the order or about 10 microns or less. The aqueous fluid within the microbubbles (31) therein is administered to the circulatory system of an animal. A catheter which allows for the infusion of the microbubbles containing fluid into the circulatory system of an animal is also disclosed.

System and method for cardiopulmonary bypass using hypobaric oxygenation

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a sub atmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the sub atmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

Bubble oxygenator

The oxygenator is used for arterializing blood during open heart surgery. The oxygenator is factory-assembled and sterilized and is of economic and efficient design so that it can serve as a throwaway unit. Blood from the patient is oxygenated as it passes through the center of a tubular sparger with porous walls which supplies oxygen bubbles of the optimum size. The foaming blood is delivered to the top of the main oxygenator body where it is distributed by gravity flow downward across the heat exchanger tubing. The heat exchanger is wound as a flat coil with all connections outside of the oxygenator body. A silicone-coated sponge is located below the heat exchanger so that downwardly flowing foaming blood is defoamed as it passes through the sponge. Carbon dioxide and other gases are vented, and liquid blood gravitates into a tapered arterial reservoir.

Extracorporeal circuit for CO2 removal from blood

The present invention relates to an extracorporeal circuit for CO2 removal from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane.

Active air removal from an extracorporeal blood circuit

A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components ...

ARRANGEMENT FOR IMPROVING THE EXCHANGE OF GASES VIA SEMIPERMEABLE MEMBRANES IN AN AQUEOUS MEDIUM

酸素運搬体投与システム、酸素運搬体酸素化装置および酸素運搬体用収容体

Apparatus for introduction of a gas into a body fluid, a tissue fluid or a culture fluid comprises a channel with a gas outlet opening which is closed by means of gas-permeable barrier element

Apparatus for introduction of a gas into a body fluid, a tissue fluid or a culture fluid comprises at least one channel (2) with at least one gas outlet opening (3) which is closed by means of a gas-permeable barrier element (1).

ANORDNUNG UND VERFAHREN FUER DIE KONTINUIERLICHE BLUTTRENNUNG IN SITU.

BLUTPUMP VORRICHTUNG FÜR EINEN EXTRAKORPORALEN KREISLAUF UND ZUR HERZUNTERSTÜTZUNG

BLASENDETEKTOR UND KALIBRIERUNGS- UND AUSWERTUNGSMETHODE DAFÜR

Cuvette for haematogenic oxidation therapy

The cuvette for haematogenic oxidation therapy has a quartz glass tube (10) with a dia. of less than 8 mm and pref. less than 6 mm, with an eddy unit (11). The leg (22) for the oxygen feed, of the connected Y-piece (20), has a microfilter (24) for the foaming action.

Vorrichtung mit einer Fluidpumpe, mindestens zwei Bauchdeckenzugängen und Fluidpumpe und Bauchdecke verbindenden Schläuchen

Eine Vorrichtung mit einer Blutpumpe, mindestens zwei Bauchdeckenzugängen und Blutpumpe und Bauchdeckenzugänge verbindenden Schläuchen, die als Peritoneal-Dialyse-System bekannt ist, wird mit einer CO2-Entfernungseinrichtung ausgerüstet, um sie zur Blutoxygenierung und zur CO2-Entfernung einzusetzen.

Überwachungssystem für herzchirurgische Operationen mit kardiopulmonalem Bypass

Improvements in or relating to devices for circulating blood

... 1, 046, 098. Oxygenating blood in an extracorporeal circuit. PRESNA MECHANIKA, NARODNY PODNIK. July 1, 1964 [July 3, 1963], No. 27133/64. Heading A5R. Apparatus for the extracorporeal circulation and oxygenation of blood comprises a compressed oxygen source 4, an oxygenator 5 supplied with oxygen from the source and two diaphragm pumps actuated by the oxygen under the control of a fourway valve 2 for drawing blood through the oxygenator and returning it to the body. Blood flows from the patient by gravity through a tube 9 into an oxygenator 5 wh ere oxygen from a source 4 is bubbled through it. Oxygenated blood passed from the lower part of the oxygenator 5 to a reservoir 10 from which it is drawn by two alternately operating diaphragm pumps 21, 22 and returned to the body through a tube 20. A partition on the oxygenator assists in removing oxygen bubbles from the outflowing blood, oxygen escaping through an opening 6. Each pump comprises a rigid case 11, 12 surrounding a flexible hose ...

DEVICE FOR SIMULTANEOUS DIFFUSION AND TEMPERING OF FLUIDS

Control system

Oxygenation system

A pressure-isolating component for an oxygenator 20 of an extracorporeal ventilation system has an oxygenation gas inlet GI for supply of oxygenation gas, an exhaust chamber 1, and exhaust ports 28 permitting gas passage from the exhaust chamber 1 to the oxygenator exterior 2. The pressure isolating component 40 comprises a pressure relief arrangement activating at a pressure relief threshold and is thereby configured to inhibit pressure equalising between the exhaust chamber 1 and the oxygenator 20 exterior unless the pressure in the exhaust chamber 1 exceeds the pressure relief threshold and thereby causes the pressure-relief arrangement to activate and permit pressure equalising between the exhaust chamber 1 and the oxygenator exterior 2. The component 40 is provided as a cap to fit over the exhaust ports 28, and has duckbill valves 42 which open when the pressure in the oxygenator chamber exceeds their pressure relief threshold.

Blood Oxygenator

An oxygenator for blood employs a unique and inexpensive, tubular, finned heat exchanger, one type utilizing a spirally wound plate attached to the tube, and another type comprising longitudinal fins. The oxygenator provides a fairly uniform oxygen saturation which permits better control over the oxygen content in a patient's blood. Also, elevated inlet oxygen pressures can be reduced, and this lessens the possibility of embolii due to cavitation effects when CO2 is released by the blood following oxygenation. A preferred form of a sparger for inlet oxygen to the blood is made of a porous, hydrophobic plastic material such as high density polyethylene.

BLOOD OXYGENATOR

TREATMENT OF STRESS AND VORBEHANDLNG AGAINST STRESS

PROCEDURE FOR DIAPHRAGM LOTS MICRO FLUID EXCHANGE IN A H-FILTER AND A FILTERING OF EXTRACTION LIQUID OUTPUT CURRENTS

USE OF BLOOD WITH INCREASED NITROGEN OXIDE CONCENTRATION FOR THE PRODUCTION OF A MEDICINE

DEVICE AND PROCEDURE FOR THE SUPERSATURATION OF A LIQUID WITH GAS

OZONE STERILIZATION OF BLOOD AND BLOOD PRODUCTS.

BLOOD AERATION DEVICE.

EXPENDABLE CARTRIDGE FOR MANUFACTURING WITH GAS ENRICHED LIQUIDS

Equipment for simulating the pulsating flow conditions produced by the heart in the Blutkreislauf

Treatment of autoimmune diseases

Method of inhibiting the aggregation of blood platelets

Methods and systems for the delivery of dissolved gases and de-gassing medical fluid lines

A method and system for infusing medical liquid with gasses, the system comprising a gas source, a vacuum pump, a temperature-controlled container including a fluid reservoir coupled to the gas source and the vacuum pump, a heating and cooling system, and a sonicator, and a controller configured to de-gas a liquid in the fluid reservoir by activating the vacuum pump, re-gas the liquid in the fluid reservoir by releasing gas from the gas source to the fluid reservoir via a first fluid line, and deliver the re-gassed liquid from the fluid reservoir to a catheter via a second fluid line.

APPARATUS FOR THE CONTROLLED GENERATION AND ADMINISTRATION OF OZONE

Apparatus (2) for the controlled generation and administration of ozone, which apparatus (2) comprises generator means (4) for generating ozone, monitor means (6) for monitoring the ozone, dosage means (8) for providing a correct amount of ozone for administration, and computer control means (77) for controlling the operation of at least one of the generator means (4), the monitor means (6) and the dosage means (8).

BUBBLE OXYGENATOR

METHOD AND APPARATUS FOR CONTROLLED REOXYGENATION

A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenation blood and oxygenated blood are collected and oxygen levels are measured by sensors, (420, 425). The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor (450). The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.

BLOOD OXYGENATOR

METHOD FOR EXTRACORPOREAL LUNG SUPPORT

The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid. In contrast to extracorporeal carbon dioxide removal methods of the prior art (ECCCbR), the present invention employs a versatile dialysis liquid that allows to adjust the pH and buffering capacity of the dialysis liquid ...

METHOD AND APPARATUS FOR MITIGATING ACUTE REOXYGENATION INJURY DURING PERCUTANEOUS CORONARY INTERVENTION

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based subsystem which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

SPARGER FOR PLASTIC FILM BUBBLE OXYGENATOR

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

LIQUID COLLECTION CONTAINER AND EXTRACORPOREAL CIRCUIT

A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space. 1. An extracorporeal circuit for extracorporeally circulating blood , comprising:a blood reservoir possessing a storage chamber for temporarily storing liquid, the reservoir comprising a tube having an upper end, the reservoir having a lower end opening at a bottom region of the storage chamber;an arterial line connectable to a patient during extracorporeal circulation to receive blood from the patient;a venous line connectable to a patient during extracorporeal circulation to return blood to the patient;a pump connected to the lower end opening of the blood reservoir;the upper end of the tube of the blood reservoir being adapted to be connected to a source of priming solution;an oxygenator connected to the arterial line and the pump to effect gas exchange on the blood from the patient;a flexible collection container possessing an interior for collecting the priming solution;a partition in the interior of the collection container dividing the interior of the collection container into a first space positioned above a second space;a branch line in fluid communication with the venous line and branching from the venous line, the first space being in fluid communication with the branch line;the interior of the collection container comprising a communication part for establishing communication between the first space and the second space; andwherein the priming solution is ...

EXTRACORPOREAL PHOTODYNAMIC BLOOD ILLUMINATION (IRRADIATION) FOR THE TREATMENT OF CARBON MONOXIDE POISONING

Treatment of carbon monoxide poisoning of a body by removal of a portion of the blood from the body, placing the portion in an exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The intensity and wave length of the light is sufficient to dissociate a therapeutically-effective amount of carbon monoxide from the hemoglobin in the blood. The blood is circulated from and to the body through a concentric double lumen cannula. The wave lengths of the light are 540 and/or 570 nanometers. The cell exposes the blood to at least 9.5 Joules of dissociative light per milliliter of blood, and least 9.5 Watts of dissociative light per milliliter of blood per second. Oxygen is provided to, and the dissociated carbon monoxide is removed from the system. 1. A system for treatment of carbon monoxide poisoning of the blood of a living victim , comprising:a. an exposure cell,b. a first sub-system adapted to remove a portion of the blood from the victim and to place the portion in the exposure cell,c. a second sub-system adapted to expose the portion in the cell to dissociative light that causes dissociation of carbon monoxide from hemoglobin, andd. a third sub-system adapted to return the portion to the victim.2. A system as recited in claim 1 , wherein the dissociative light is of a wave length selected from the group of 540 and 570 nanometers and combinations thereof.3. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Joules per milliliter of blood.4. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Watts per milliliter of blood flow per second.5. A system as recited in claim 1 , wherein the first and third sub-systems are a concentric double lumen cannula.6. A system as recited in claim 1 , wherein the system includes a subsystem that injects oxygen into ...

Method and Apparatus for Controlled Reoxygenation

A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.

INTEGRATED PERFUSION DEVICE

An integrated perfusion apparatus or device for use in e.g. extracorporeal membrane oxygenation, cardiopulmonary bypass, or isolated organ or limb perfusion, comprises a blood pump for circulating blood through the device; a blood oxygenator for oxygenating blood, and at least one heat control unit capable of controlling and/or regulating blood temperature within the device, wherein the at least one heat control unit comprises at least one solid state heating and/or cooling source, such as at least one Peltier device. The invention also relates to a method of performing perfusion on a patient, limb or organ, comprising using the perfusion device. 168-. (canceled)69. An integrated perfusion device comprising:a blood pump for circulating blood through the device;a blood oxygenator for oxygenating blood; andat least one heat control unit capable of controlling and/or regulating blood temperature within the device, wherein the at least one heat control unit comprises at least one solid state heating and/or cooling source.70. An integrated perfusion device according to claim 69 , wherein the at least one solid state heating and/or cooling source is capable of both heating and cooling.71. An integrated perfusion device according to claim 69 , wherein the at least one solid state heating and/or cooling source comprises at least one of a solid-state thermoelectric heat pump and a Peltier device.72. An integrated perfusion device according to claim 69 , wherein:the at least one heat control unit comprises at least one heat exchanger for regulating and controlling blood temperature; andthe at least one heat exchanger comprises a first side or portion at least one of in contact with, in proximity with, and associated with the blood to be heated and/or cooled, such that the at least one heat exchanger does not extend into the blood flow path.73. An integrated perfusion device according to claim 72 , wherein the at least one heat exchanger comprises a second side or portion at ...

EXTRACORPOREAL CIRCUIT FOR REMOVING CO2 FROM BLOOD

An extracorporeal circuit for removing COfrom blood comprising a blood taking line for taking blood from the patient, an oxygenation assembly and a blood re-introduction line for re-introducing blood into the patient. The oxygenation assembly comprises an oxygenator, a dialyzer arranged upstream of the oxygenator, a circulation circuit for the circulation of a dialyzer bath connected to the dialyzer and an acidifier arranged to introduce an acid substance into the circulation circuit for circulation of the dialyzer bath. 1. An extracorporeal circuit for removing COfrom blood , comprising:a blood taking line for taking blood from the patient;an oxygenation assembly; anda blood re-introduction line for re-introducing blood into the patient, wherein said oxygenation assembly comprises an oxygenator, a first dialyzer, which is arranged upstream from the oxygenator, a circulation circuit for the circulation of a dialyzer bath and connected to the dialyzer, an acidifier, which is suited to introduce an acid substance into the circulation circuit of the dialyzer bath, and basic neutralization means which are arranged downstream of oxygenator.2. The extracorporeal circuit for removing COfrom blood according to claim 1 , wherein the basic neutralization means comprise a second dialyzer claim 1 , in which a respective basic dialyzing solution circulates.3. The extracorporeal circuit for removing COfrom blood according to claim 1 , wherein said circulation circuit of the dialyzer bath is a circulation circuit of plasma water.4. The extracorporeal circuit for removing COfrom blood according to claim 3 , wherein said first dialyzer is a haemofilter.5. The extracorporeal circuit for removing COfrom blood according to claim 1 , wherein said oxygenator is a membrane oxygenator. The present invention concerns an extracorporeal circuit for removing COfrom blood.In the past, various solutions have been devised for removing COfrom blood. Many of these solutions entail extracorporeal ...

Extracorporeal circuit for removing co2 from blood

An extracorporeal circuit for removing CO 2 from blood comprising a blood taking line for taking blood from the patient, an oxygenation assembly and a blood re-introduction line for re-introducing blood into the patient. The oxygenation assembly comprises a first dialyzer connected to a circulation circuit for the circulation of a dialyzer bath, an oxygenator which is arranged on the circulation circuit, an acidifier, which is suited to introduce an acid substance into the circulation circuit upstream of the oxygenator, and basic neutralization means which are arranged downstream of the dialyzer.

MONITORING SYSTEM FOR CARDIAC SURGICAL OPERATIONS WITH CARDIOPULMONARY BYPASS

A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value. 1. A monitoring system for cardiac operations with cardiopulmonary bypass utilizing a heart lung machine and an oxygenator fluidly coupled to the heart lung machine , the monitoring system comprising:means to obtain an arterial oxygen saturation value;means to obtain a venous oxygen saturation value;means to obtain a hematocrit value;a pump flow reading device configured to obtain a pump flow rate from a pump of the heart lung machine;a processor operably connected to the means to obtain an arterial oxygen saturation value, the means to obtain a venous oxygen saturation value and the means to obtain a hematocrit value, the processor configured to calculate an oxygen delivery value and an oxygen consumption value; anda display operably connected to the processor, the display configured to display each of the arterial oxygen saturation value, the venous oxygen saturation value, the hematocrit value, the oxygen delivery value, the oxygen consumption value and the pump flow rate.2. The monitoring system of claim 1 , wherein ...

PERFUSION SYSTEM WITH RFID FEATURE ACTIVATION

The disclosure pertains to a perfusion system that is easy to set-up, use and monitor during a bypass procedure. In some embodiments, the disclosure pertains to a perfusion system in which at least some of the disposable components used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system in order to unlock further functionality within the perfusion system. 1. An integrated perfusion system comprising:a heart lung machine including a controller in communication with each of the control units;', 'an input device in communication with the controller and configured to accept operational settings information from a user; and', 'an output device in communication with the controller and configured to display operational parameters of the plurality of pump modules;, 'a plurality of pump modules, each pump module having a control unit;'} an RF sensor; and', 'a processor in communication with the RF sensor; and, 'a data management system in communication with the controller, the data management system including'}one or more disposable elements configured to be used in conjunction with the heart lung machine and including an RFID tag programmed with identifying information that can be read by the RF sensor and used by the processor to unlock functionality within the data management system.2. The integrated perfusion system of claim 1 , wherein the data management system is configured to receive and record data from the heart lung machine and optionally from external sources.3. The integrated perfusion system of claim 2 , wherein the data management system is configured to display data received from the heart lung machine and optionally from external sources.4. The integrated perfusion system of claim 1 , wherein the one or more disposable elements include one or more of a blood reservoir claim 1 , an oxygenator claim 1 , a heat exchanger claim 1 , or an arterial filter.3. The integrated perfusion ...

Gas exchanger and artificial lung

O 2 and CO 2 can be exchanged with blood by passing the blood through a void within a bundle of nanotubes, where the ends of the nanotubes are open to a gas flow channel. The void in the bundle is configured to form a flow channel that is large enough to permit the red blood cells to flow therethrough. The nanotubes in the bundle are spaced close enough to retain the red blood cells within the flow channel, yet far apart enough to permit blood plasma to flow through spaces between adjoining nanotubes in the bundle, and the nanotubes in the bundle have defects in their walls that permit O 2 molecules and CO 2 molecules to diffuse therethrough. The defects are present in a sufficient number and total area to effectively deliver O 2 to the blood and carry away CO 2 from the blood. Alternative embodiments may be used for fluids other than blood.

Blood perfusion system

An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.

BLOOD OXYGENATION SYSTEM

A blood oxygenation system which prevents transmigration of blood to gaseous oxygen circuitry. The system includes a blood circuit, an oxygen supply circuit, an oxygen-blood interface in which gaseous oxygen is absorbed into the blood, and an oxygen disposal circuit for disposing of unused oxygen. The oxygen-blood interface is arranged to prevent transmigration of blood into the oxygen circuit. The blood circuit includes a pump and a blood de-aerator. The oxygen supply circuit includes an oxygen supply, an ozone generator, and an ozone destructor. A silica gel trap in the oxygen disposal circuit separates Ofrom ozone prior to the latter entering the ozone destructor. 1. A blood oxygenation system for infusing blood of a patient with oxygen and returning oxygenated blood to the patient , comprising:a blood circuit including an extraction port for obtaining blood from the patient, a return port for returning oxygenated blood to the patient, a blood conduit connected to the extraction port and the return port, a blood pump serially located in the blood conduit, and a de-aerator for separating air from oxygenated blood, located in the blood circuit prior to the blood return port;an oxygen supply circuit including an oxygen supply, and an ozone generator fed oxygen from the oxygen supply;a blood-oxygen interface which dissolves into the blood gaseous oxygen supplied from the oxygen supply circuit; andan oxygen disposal circuit for discharging oxygen not absorbed by the blood in the blood-oxygen interface, whereinthe blood-oxygen interface prevents transmigration of blood into the oxygen supply circuit and into the oxygen disposal circuit.2. The blood oxygenation system of claim 1 , wherein the oxygen disposal circuit further comprises an ozone destructor.3. The blood oxygenation system of claim 2 , wherein the oxygen disposal circuit further comprises an oxygen-ozone separator claim 2 , with only ozone being conducted to the ozone destructor.4. The blood oxygenation ...

Apparatus for Making Extracorporeal Blood Circulation Available

The present invention relates to an apparatus or making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.

Peritoneal Dialysis System and Method

A peritoneal dialysis machine that includes a base, a boiling vessel, a condenser, a fluid storage vessel, a sterilizing UV lamp, a fluid mixer, a dialysate cassette, a boiling vessel demineralizing system, and an optional fluid storage vessel rinsing system. The peritoneal dialysis machine automatically generates a predetermined volume of distilled water each day. Pre-weighed quantities of low-endotoxin dialysate chemicals are then mixed into the warm distilled water, and the resulting peritoneal dialysate is sterilized via exposure to ultraviolet radiation. These actions are complete by the patient's indicated bed time. The peritoneal dialysis machine then exchanges spent peritoneal dialysate in the user's peritoneal cavity with fresh peritoneal dialysate throughout the night, causing each infusion of fresh dialysate to dwell in the user's peritoneal cavity for a predetermined time. All spent fluids are routed from the peritoneal dialysis machine to a toilet or a sewer drain. 1. A peritoneal dialysis system comprising: a boiling vessel that generates steam; a condenser that condenses the steam; a fluid storage vessel that collects the condensate; an ultraviolet lamp that sterilizes the fluid in the fluid storage vessel; a fluid mixer; a dialysate cassette; and a dialysate pump.2. The peritoneal dialysis system of claim 1 , further comprising a boiling vessel constant fluid level mechanism claim 1 , which includes an automatically-controlled valve.3. The peritoneal dialysis system of claim 1 , further comprising an automatically-controlled boiling vessel drain valve.4. The peritoneal dialysis system of claim 1 , further comprising a boiling vessel demineralization system.5. The peritoneal dialysis system of claim 1 , further comprising a demister that is configured such that water vapor flows from the boiling vessel claim 1 , through the demister claim 1 , and into the condenser.6. The peritoneal dialysis system of claim 1 , further comprising an ultraviolet lamp ...

Dual lumen cannula for artificial lung and right ventricular assist device

A dual lumen cannula includes a first lumen having at least one aperture for removing a fluid from the interior of the heart right atrium, and a second lumen for delivering a fluid into the interior of the pulmonary artery or the heart left atrium. The second lumen includes a distal selectively curvable portion having a length of from about 4 cm to about 22 cm to position an end thereof within the interior of the pulmonary artery lumen or the human heart left atrium interior when a distal end of the first lumen is positioned within a right atrium of the human heart. The second lumen may also include a distal anchoring structure for preventing inadvertent withdrawal from a surgical site.

Hyperoxygenation/Hyperthermia Treatment Apparatus

The described invention is a hyperthermia and hyperoxygenation medical apparatus for treating diseases of the blood and purification of stored blood supplies. The invention comprises a hollow chamber through which blood is made to flow. Within the hollow chamber are a heating element and a gas diffuser. As blood flows through the chamber, blood is heated to a preset limit while ozone or other beneficial gas is diffused into the blood by a diffuser with pores to a preset concentration. After heating and gasification, blood exits the hollow chamber and is either returned to the patient or returned to storage. The hollow chamber, heating element and gas diffuser are designed to maintain efficient, linear blood flow through the invention, in part by taking advantage of die radial symmetry of the hollow chamber and diffuser designs. Linear flow ensures uniform and controlled heating and gasification of the blood with negligible undesirable turbulence to the blood components. 1. A device for treating illnesses of the blood comprisinga chamber suitable to have blood pumped through itan heater and gas diffuser combination positioned on the longitudinal axis of the chamberin which the space between the heater and gas diffuser combination and the inner surface of the chamber have cross-sectional radial symmetry along the said longitudinal axis of the chamberand further in which the radial thickness of blood pumped between the heater and gas diffuser combination and the inner surface of the chamber permits conductive heating of all of the pumped blood in the time the blood flows through the chamber between the heater/oxygenator combination and the inner wall of the chamber.2. The device of in which the heater heats the blood pumped through the device to a specified temperature between 105 degrees F. and 106.7 degrees F.3. The device of in which the heater heats the blood to one or more desired temperatures between 105 degrees F. and 106.7 degrees F.4. The device of in which ...

Method and apparatus for mitigating acute reoxygenation injury during percutaneous coronary intervention

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

METHOD AND APPARATUS FOR PERITONEAL OXYGENATION

Embodiments of the invention provide apparatus, systems and method for introducing fluids into a body cavity for treatment. One embodiment provides an apparatus for treating a patient including an access device for insertion into the peritoneal cavity of the patient including an infusion member in a lumen of the access device. An oxygenated solution may be infused and removed into and out of the cavity via the infusion member. 120.-. (canceled)21. A method of cooling a body cavity of a patient , comprising:monitoring a depth of an access device inserted within a body cavity, the access device having a valve for controlling a fluid flow from the body cavity;introducing a volume of air into the body cavity such that the body cavity is expanded into a distended shape;introducing a hypothermic solution through a lumen of the access device and into the body cavity such that the body cavity is cooled while expanded into the distended shape;monitoring a pressure within the body cavity; andcontrolling an infusion of the hypothermic solution such that excessive pressure buildup within the body cavity is inhibited.22. The method of wherein monitoring the depth comprises determining when a tip of the access device has entered the body cavity.23. The method of wherein the access device is inserted within a peritoneal cavity of the patient.24. The method of wherein the access device comprises a tissue penetrating distal end.25. The method of further comprising removing the hypothermic solution from the body cavity via a second lumen of the access device.26. The method of wherein removing the hypothermic solution comprises removing the hypothermic solution from the body cavity while simultaneously introducing the hypothermic solution into the body cavity in parallel.27. The method of wherein monitoring the pressure comprises monitoring the pressure via an electronic controller.282. The method of further comprising monitoring a CO level of the patient via an electronic controller. ...

Method and System for Controlled Hyperthermia

An improved system and methods for treatment of cancer and other diseases including complications from late-stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented. An adjunct of the present invention is enhanced production of stem cells as a result of employing the HEATT process. A further adjunct is production of transgenic swine with extant viral infections. 1. An improved method for inducing hyperthermia in a patient , said method comprising:a. slowly withdrawing a portion of blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit;b. passing water or another heat exchange medium through a heat exchanger to heat the blood;c. slowly heating blood passing through the extracorporeal circuit at a rate in the range from 0.05° C./min to 0.15° C./min in order to prevent vascular collapse until a target body core temperature in the range from 41.8° C. to 42.2° C. is achieved;d. maintaining the blood ...

EXTRACORPOREAL PHOTODYNAMIC BLOOD ILLUMINATION (IRRADIATION) CELL FOR THE TREATMENT OF CARBON MONOXIDE POISONING

An exposure cell and method for treatment of carbon monoxide poisoning in the blood of a living body by removal of a portion of blood from the body, placing the portion in the exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The exposure cell has an exposure zone outside of the body, that holds the portion, and a window that allows light from outside the zone to enter the zone to disassociate carbon monoxide from the portion. Oxygen is injected into the zone and carbon monoxide is removed from the zone. 1. An exposure cell for treatment of carbon monoxide poisoning in the blood of a living body by removal of a portion of blood from the body , placing the portion in the exposure cell , exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin , and returning the portion to the body , comprising:a.) a light source;b.) an exposure cell that has an exposure zone outside of the body, that holds the portion, and a window that allows light from the light source, outside the zone. to enter the zone to disassociate carbon monoxide from the portion;c.) an oxygen injector that injects oxygen into the zone; andd.) a carbon monoxide extractor that removes carbon monoxide from the zone.2. A method of treatment of carbon monoxide poisoning in the blood of a living body , comprising the steps of:a.) removing a portion of blood from the body,b.) placing the portion in an exposure cell,c.) exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobind.), removing the dissociated carbon monoxide from the cell, ande.) returning the portion, with reduced carbon, monoxide to the body. This invention has been created without the sponsorship or funding of any federally sponsored research or development program.This ...

Device and Method for Attenuation of CO2 in Circulating Blood

Systems and methods for the removal of carbon dioxide from circulating blood via the use of microbubbles within a body cavity, optionally including the simultaneous provision of oxygen to the circulatory system. Through placement of microbubbles within a body cavity and the use of a carbon dioxide scavenging catheter, carbon dioxide and/or oxygen exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar ventilation restricting injury and/or failure may be achieved. 1. A method of removing a gas from a circulatory system of a subject , comprising the steps of:delivering a plurality of microbubbles containing a first gas into an existing gastrointestinal body cavity of the subject, the first gas having a first percentage by volume;inserting a gas collecting device into the first plurality of microbubbles located within the gastrointestinal body cavity, the gas collecting device comprising a gas permeable outer layer and a material capable of absorbing the selected gas;wherein a gas located within the circulatory system of the subject diffuses through a tissue wall of the gastrointestinal body, through the plurality of microbubbles and through the gas permeable outer layer and is absorbed by the gas absorbing material.2. The method of claim 1 , where the gas collecting device contains a gas absorbing material selected from one of the members of a group consisting of chitosan; soda lime; calcium hydroxide lime; calcium hydroxide; sodium hydroxide; sodium hydroxide-coated silica; potassium hydroxide; lithium hydroxide; cuprous chloride; amine based solvents claim 1 , methylamine claim 1 , triethanolamine claim 1 , hexamethylenetetramine claim 1 , cyclohexylamine claim 1 , pyridine claim 1 , diphenylamine claim 1 , ethylenediamine claim 1 , ethylpiperidine claim 1 , benzimdazole claim 1 , triazine claim 1 , triphenylphosphine claim 1 , dimethylphosphine and any combinations thereof.3. The method of ...

EXTRACORPOREAL AMBULATOR ASSIST LUNG

A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing. 1. A extracorporeal system for lung assist comprising:a housing,a blood flow inlet in fluid connection with the housing;a blood flow outlet in fluid connection with the housing;a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet, the plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the housing;a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers;a gas outlet in fluid connection with ...

ARRANGEMENT WITH A BLOOD PUMP AND A GAS EXCHANGER FOR EXTRACORPOREAL MEMBRANE OXYGENATION

The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient. 1. A method for pumping and oxygenating blood , said method comprising:providing a housing having a blood inlet, a blood outlet, a pulsatile blood pump, a gas exchanger, an oxygenation gas inlet, and a pulsatile gas inlet;connecting the blood inlet to a patient's venous vasculature and the blood outlet to the patient's arterial vasculature;connecting an external pulsatile gas source to the pulsatile gas inlet to drive the pump; andconnecting an external oxygenation gas source to the oxygenation gas inlet to oxygenate the blood.2. The method for pumping and oxygenating blood according to claim 1 , wherein connecting the blood inlet to the patient's venous vasculature and the blood outlet to the patient's arterial vasculature comprises implanting cannulas or tube connections.3. The method for pumping and oxygenating blood according to claim 2 , wherein the cannulas or tube connections are connected to the patient by a blood inlet line and a blood outlet line claim 2 , each having a length of 80 cm or less.4. The method for pumping and oxygenating blood according to claim 3 , wherein the blood inlet line and the blood outlet line are oriented in the same direction.5. The method for pumping and oxygenating blood according to claim 3 , wherein the blood inlet line and the blood outlet line are on the same side of the housing.6. The method for pumping and oxygenating blood according to claim 1 , wherein the pulsatile blood pump is axially aligned with gas ...

CARDIOPULMONARY APPARATUS AND METHODS FOR PRESERVING LIFE, PRESERVING ORGAN VIABILITY AND/OR FOR USE DURING PCI AND CABG

Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage deairing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure such as; cardiopulmonary bypass graft surgery, keyhole cardiopulmonary bypass graft surgery, percutaneous angioplasty, percutaneous stent placement, and percutaneous atherectomy, repairing or replacing the heart valve and/or for perfusing an organ or the body of an organ donor to preserve viability of organ(s) for transplantation. 1a) priming a heart-lung machine with a priming liquid in a priming mode;b) switching the heart lung machine from the priming mode to an operational mode;c) connecting a venous blood inlet on the heart lung machine to a vein in the. A method for providing extracorporeal circulation to a patient or organ donor comprising the steps of:d) operating the heart-lung machine in said operational mode to take venous blood from the patient, oxygenate the venous blood, and return oxygenated blood to the patient or organ donor; andwherein:said heart-lung machine comprises a centrifugal pump head having a central inletand a tangential outlet; andsaid central inlet to the centrifugal pump head is oriented vertically upward duringpriming step a) and horizontally during operating step d.patient or organ donor and connecting an arterial blood outlet from the heart lung machine to an artery in the patient or organ donor to form a closed extracorporeal blood circulation in fluid contact with the patient or organ donor's circulatory system; This application is a continuation in part of:Also incorporated by reference in this application are the entire disclosures of each of the following: U.S. patent application Ser. No. 11/284,515 filed Nov. 22, 2005 entitled Apparatus For Making Extracorporeal Blood Circulation Available; European Patent Application No. EP 04 027 855.8 filed on Nov. 24, 2004 entitled Vorrichtung zur Bereitstellung ...

METHOD AND DEVICE FOR TRANSFERRING GAS MOLECULES FROM A GASEOUS MEDIUM INTO A LIQUID MEDIUM OR VICE VERSA

The present invention relates. to methods and devices for exchanging gas molecules between a gaseous medium and a liquid medium which are particularly suited for applications such as blood oxygenation in heart-lung machines and gas scrubbing. The method of the invention comprises the following steps: a) providing a liquid medium having a surface tension in the range of from 0.02 N/m to 0.06 N/m, b) providing a gaseous medium, c) providing a membrane on an interface between the liquid medium and the gaseous medium, wherein the membrane comprises i) a carrier substrate with through-going openings having a mean diameter in the range from 0.2 μιη to 200 μπι, and ii) a porous superamphiphobic coating layer with openings having a mean diameter in the range from 0.1 μm to 10 μm, which is provided at least on the substrate surface facing the liquid medium, wherein either the liquid medium or the gaseous medium, preferably the gaseous medium, comprises at least one target gas to be transferred and said membrane is permeable for the at least one gas to be transferred and not permeable for the liquid medium due to the super-amphiphobic properties of the membrane surface facing the liquid medium with respect to said liquid medium, d) contacting the gaseous medium with the liquid medium via said superamphiphobic layer for a sufficient time to enrich the liquid or gaseous target medium with the at least one gas to be transferred. 1. A method for transferring gas molecules from a gaseous medium into a liquid medium or vice versa comprising at least the following steps:a) providing a liquid medium having a surface tension (liquid-air) in a range of from 0.02 N/m to 0.06 N/m,b) providing a gaseous medium,c) providing a membrane on an interface between the liquid medium and the gaseous medium, wherein the membrane comprisesi) a carrier substrate with through-going openings having a mean diameter in a range from 0.2 μm to 200 μm, andii) a porous superamphiphobic coating layer with ...

Steerable Aspiration Catheter System

A system for removing material from the body of a patient, the system including a aspiration catheter insertable into the patient having a distal end with a steerable tip configured to bend in one or more directions and a controller mechanically coupled to the aspiration catheter and operable by a user to bend the steerable tip in the one or more directions. The system may also include a pump having an inlet port in fluid communication with the aspiration catheter and a discharge port in fluid communication with a return catheter configured to be inserted into the patient to return aspirated blood to the patient. A filter device may be positioned between the aspiration catheter and the pump, the filter device configured to trap solid material received in the aspiration catheter from the body of the patient. 1. A system for removing material from the body of a patient , the system comprising:an aspiration catheter insertable into the patient comprising a distal end having a steerable tip configured to bend in one or more directions;a controller mechanically coupled to the aspiration catheter and operable by a user to bend the steerable tip in the one or more directions;a pump comprising an inlet port and a discharge port, the inlet port being in fluid communication with the aspiration catheter, the pump configured to generate a negative pressure at the inlet port and a positive pressure at the discharge port during use; anda return catheter in fluid communication with the discharge port of the pump and configured to be inserted into the patient.2. The system according to claim 1 , wherein the aspiration catheter has a size equal to or greater than 10 Fr.3. The system according to claim 1 , wherein the aspiration catheter has a lumen diameter of at least 3 mm.4. The system according to claim 1 , wherein the negative pressure at the inlet port is between 0 mmHg to about −150 mmHg.5. The system according to claim 1 , wherein the pump is configured to generate a flow ...

Method and Apparatus for Controlled Reoxygenation

A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation. 1. A perfusion device for controlled reoxygenation , the device comprising:a perfusion control input operable to receive a desired blood oxygen level;a venous blood sensor operable to measure oxygen levels in venous blood;an oxygenated blood sensor operable to measure oxygen levels in oxygenated blood;a mixed blood supply operable to receive venous blood and oxygenated blood;a mixed blood sensor operable to measure oxygen levels in the mixed blood supply; anda venous blood pump operable to move venous blood to the mixed blood supply;an oxygenated blood pump operable to move oxygenated blood to the mixed blood supply;a microprocessor operable to receive data from said perfusion control input, said venous blood sensor, said oxygenated blood sensor, and said mixed blood sensor,wherein the microprocessor controls the venous blood and oxygenated blood pumps to provide a desired blood oxygen level in the mixed blood supply.2. The perfusion device of wherein the mixed blood supply is a reservoir claim 1 , blood line claim 1 , or bladder.3. The perfusion device controller of further comprising a mixed blood supply pump connected with said mixed blood supply.4. The perfusion device of wherein the oxygen levels comprise partial pressure of oxygen.5. The perfusion device of wherein the oxygen levels comprise oxygen saturation.6. The perfusion device of wherein the oxygen levels comprise oxygen saturation and partial pressure of oxygen.7. The perfusion device of further ...

SYSTEMS AND METHODS FOR TREATING BLOOD

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees. 174-. (canceled)75. A method for treating cancer , comprising:heating a human body to a core temperature between 42 and 43.2 degrees Celsius, wherein blood from the human body is flowing outside of the human body in a fluid flow path; andremoving carbon dioxide from at least a portion of the blood flowing in the fluid flow path.76. The method of claim 75 , further comprising adding oxygen to at least a portion of the blood.77. The method of claim 75 , wherein carbon dioxide is removed from at least a portion of the blood by causing at least a portion of the blood to flow through at least one membrane.78. The method of claim 77 , wherein the at least one membrane collectively has an effective surface area greater than 1.8 square meters.79. The method of claim 75 , further comprising causing the production of reactive oxygen species within the human body by adding a substance to at least a portion of the blood outside of the human body.80. The method of claim 75 , further comprising performing convection dialysis on at least a portion of the blood at a rate between 0.5 and 1.8 liters per minute.81. The method of claim 75 , further comprising pumping blood from the human body into the fluid flow path at a rate between 4 and 7 liters per minute.82. The method of claim 75 , wherein the blood is pumped in the ...

CARDIOPULMONARY APPARATUS AND METHODS FOR USE DURING PCI AND CABG

Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage deairing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure such as cardiopulonary bypass graft surgery, keyhole cardiopulmonary bypass graft surgery, percutaneous angioplasty, percutaneous stent placement, and percutaneous atherectomy. 117-. (canceled)20. The method of claim 19 , wherein said fast closing clamp jaw is in an open position that allows a flow of fluid through a hose; the clamp jaw is latched to a holding apparatus by a latch device; the relative longitudinal position between the clamp jaw and the holding apparatus when latched together is a latching position; the latch device is manipulated to unlatch the clamp jaw from the holding apparatus; the clamp jaw moves in the longitudinal direction after being unlatched from the holding apparatus to a clamping position by a separating force tending to move the clamp jaw away from the holding apparatus; the clamp jaw prevents the flow of fluid through the hose while in the clamping position; the holding apparatus is moved relative to the clamp jaw in the longitudinal direction until the holding apparatus and clamp jaw are in the latching position relative to each other while the clamp jaw is in the clamping position; the clamp jaw is latched to the holding apparatus using the latch device while the clamp jaw is in the clamping position; and the holding apparatus and clamp jaw are moved while latched together until the clamp jaw is in the open position.22. The method of claim 21 , wherein said blood reservoir is separated into a lower blood-containing space and an upper air-containing space by a membrane that is permeable to blood but not to air bubbles.23. The method of claim 21 , wherein the heart-lung machine further comprises:a bubble detector located downstream of said arterial filter and connected by an arterial line to an arterial ...

METHOD AND APPARATUS FOR MITIGATING ACUTE REOXYGENATION INJURY DURING PERCUTANEOUS CORONARY INTERVENTION

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart. 1. A reperfusion system for use in treating a patient undergoing an interventional procedure in which a blood flow to a tissue has been reduced comprising:a catheter having an occluding member; and a pump for forcing a perfusate through the vascular perfusion catheter;', 'a perfusate oxygenation modulator for controlling the oxygen level within the perfusate, and', 'a controller configured to change the oxygenation level within the perfusate from a first oxygenation level to at least a second oxygenation level, the second oxygenation level being different from the first oxygenation level., 'an oxygenation controller in fluid communication with the catheter, the oxygenation controller comprising2. The system of further comprising an oxygen sensor in electrical communication with the controller.3. The system of wherein the controller controls the oxygen level in the perfusate from a 1% oxygen level to an oxygen level below the oxygen level of venous blood.4. The system of claim 1 , further comprising an oxygen sensor in electrical communication with the controller claim 1 , the oxygen sensor sensing an actual oxygen level claim 1 , the controller comparing the actual oxygen level to the instantaneous oxygenation level.5. The system of claim 1 , further comprising at least two ...

SYSTEM FOR MONITORING AND CONTROLLING ORGAN BLOOD PERFUSION

The present invention provides a system, a method, devices and a computer implemented with a method for the monitoring and the control of a subject's organ perfusion. The present invention further provides for the use of a system, a method, devices and a computer implemented with a method for the monitoring and the control of a subject's organ perfusion. 1. A system for the monitoring and the control of a subject's organ perfusion comprising:optionally at least one therapeutic agent,at least one first retrievable medical device, for the simultaneous or the separate perfusion and occlusion of the vessel of the organ inflow, comprising a body having a distal end, a proximal end, at least one lumen extending between the proximal end and the distal end, at least one opening which is in fluid communication with the lumen for delivering a fluid to said vessel and at least one expandable balloon coupled with the body of the device,at least one second retrievable medical device for isolating and collecting the organ outflow, said device is provided with a distal end and a proximal end; wherein said second medical device comprises a catheter suitable for deploying an expanding member; and wherein the proximal end of the expanding member is attached to the distal end of the catheter,a fluid storage reservoir having at least one inlet and at least one outlet, wherein said inlet is suitable to be connected to the proximal end of the second retrievable medical device and said outlet is suitable to be connected to the proximal end of the first retrievable medical device,at least one pump for withdrawing fluid from the organ and directing said fluid to the fluid storage reservoir through the inlet of said fluid storage reservoir,at least one pump for withdrawing fluid from the fluid storage reservoir at a determined flow rate and directing said fluid to the organ inflow,optionally, at least one marker for real time monitoring of the leak rate from the organ to the systemic blood ...

MONITORING SYSTEMS FOR CARDIAC SURGICAL OPERATIONS WITH CARDIOPULMONARY BYPASS

A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value. 1a controller configured to calculate an indexed oxygen delivery value based on at least each of an arterial oxygen saturation value of a patient, the hematocrit and/or hemoglobin value of the patient, a body surface area of the patient, and the pump flow rate value; and in a first window of the display, the calculated indexed oxygen delivery value, and', 'in a plurality of windows positioned at least partially around the first window, values of physiological parameters of the patient and parameters of the monitoring system including the pump flow rate value., 'a display operably coupled to the controller, the display configured to display. A monitoring device comprising: This application is a continuation of U.S. application Ser. No. 14/064,510, filed Oct. 28, 2013, which is a continuation of U.S. application Ser. No. 13/705,169, filed on Dec. 5, 2012, now U.S. Pat. No. 8,690,784, which is a continuation of U.S. application Ser. No. 12/250,212, filed on Oct. 13, 2008, which is a division of U.S. application Ser. No. 11/ ...

INTRAVASCULAR NANO-BUBBLING OXYGENATOR

The present invention provides a intravascular nano-bubbling oxygenator comprises a catheter, capable of being inserted into a blood vessel to transport normal pressure to hyperbaric gas, comprising: a tube wall with one or two lumens, and an opening end, wherein the tube wall partially comprises a plurality of pores; a connector; a gas transporting apparatus, and a control panel with on-line data sensors connections. 1. An intravascular nano-bubbling oxygenator , comprising:a catheter comprising a tube wall having a closed end and an opening end, and capable of being inserted into a blood vessel to transport gaseous oxygen, wherein said tube wall has a hydrophobic outer surface and comprises a plurality of nano-sized pores provided along said tube wall toward said closed end, which are provided with sizes ranging from 0.3 nanometer to 500 micrometer; and said catheter has a cross-section area less than three fourths (¾) of the cross-section area of said blood vessel, wherein said tube wall is arrange for guiding said gaseous oxygen to longitudinally flow from said opening end toward said closed end in order to transversely distribute said gaseous oxygen to produce oxygen bubbles through said nano-sized pores directly inside said blood vessel.2. The intravascular nano-bubbling oxygenator of claim 1 , wherein said tube wall comprises biomaterial.3. The intravascular nano-bubbling oxygenator of claim 1 , wherein a porous area of said tube wall is five (5)% to ninety-nine (99)% of said catheter being inserted into a blood vessel.4. The intravascular nano-bubbling oxygenator of claim 1 , further including a connector provided at said opening end to input said gaseous oxygen into said catheter.5. The intravascular nano-bubbling oxygenator of claim 7 , further including a gas transporting apparatus connected to said connector.6. The intravascular nano-bubbling oxygenator of claim 5 , wherein said gas transporting apparatus comprises a flow adjustor claim 5 , a pressure ...

Implantable heart treatment systems, devices, and methods

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

The present disclosure provides a system for oxygenating blood. The system may include an implantable blood pump that may draw a supply of blood from the circulatory system of a mammalian subject, such as a human being. The blood pump may provide the supply of blood to an adaptor, where the supply of blood may be supplied to either or both of a first branch or second branch. The first branch may lead to an external blood oxygenator. The oxygenator may oxygenate the blood, and the blood may be returned to the circulatory system of the mammalian subject. The second branch may bypass the oxygenator and may connect to the circulatory system of the mammalian subject. In this regard, while the blood is supplied to the second branch, the oxygenator may be disconnected and blood may be prevented from entering the first branch. 1. (canceled)2. A portable lung assist system comprising:a blood pump having a pump outlet and a pump inlet configured for communication with a circulatory system of a mammalian subject at an inlet location, the blood pump being carriable by the mammalian subject;an external, portable blood oxygenator for supplementing the action of the subject's lungs having a blood inlet releasably connectable to the outlet of the blood pump and a blood outlet releasably connectable to the circulatory system of the mammalian subject at a return location; anda bypass conduit connectable to the outlet of the blood pump and to the circulatory system at the return location.3. The system of claim 1 , wherein the blood inlet and blood outlet are releasably connectable while the blood pump and bypass conduit are connected to the circulatory system.4. The system of claim 1 , further comprising first and second return fittings adapted for connection to the circulatory system at the return location and adapted for respective connection to the blood outlet and bypass conduit.5. The system of claim 1 , wherein the inlet location and return location are located within the same ...

EXTRACORPOREAL BLOOD HEATING AND COOLING SYSTEM AND METHOD OF OPERATING AND MAINTAINING SAME

An extracorporeal blood heating and cooling system that is connectable to an oxygenator of a cardiopulmonary bypass system, the heating and cooling system comprising: a heater-cooler unit; a coolant flow circuit that is configured to pass coolant through the heater-cooler unit and the oxygenator; and a cardioplegia coolant circuit that is configured to pass coolant through the heater-cooler unit and a cardioplegia heat exchanger; wherein when the heating and cooling system is in a purging mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-35 millimole/liter; wherein when the heating and cooling system is in a coolant mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-10 millimole/liter; and wherein when the heating and cooling system is in the coolant mode or the purging mode, a first and second plurality of coolant conduits within the oxygenator and the cardioplegia heat exchanger are capable of maintaining a trisodium phosphate concentration ratio across the wall of such coolant conduits of at least 100:1, from the interior to the exterior of each coolant conduit. Methods of purging and operating such extracorporeal blood heating and cooling systems are also disclosed. 1. An extracorporeal blood heating and cooling system that is connectable to an oxygenator of a cardiopulmonary bypass system , the heating and cooling system comprising:a heater-cooler unit;a coolant flow circuit that is configured to pass coolant through the heater-cooler unit and the oxygenator; anda cardioplegia coolant circuit that is configured to pass coolant through the heater-cooler unit and a cardioplegia heat exchanger;wherein the oxygenator comprises a first plurality of coolant conduits that form part of the coolant flow circuit, and wherein when the heating and cooling ...

ARRANGEMENT WITH A BLOOD PUMP AND A GAS EXCHANGER FOR EXTRACORPOREAL MEMBRANE OXYGENATION

The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient. 1. An arrangement comprising:a housing having a blood inlet, a blood outlet, and at least one gas inlet;a blood pump within the housing and comprising an expandable member connected to receive gas from the at least one gas inlet;a gas exchanger for extracorporeal gas exchange within the housing;a gas source external to the housing and having at least one gas outlet;wherein the blood pump is arranged to deliver blood from the blood inlet to the gas exchanger,wherein the gas inlet is connected to receive gas from the at least one gas outlet of the external gas source to provide pumping power to the expandable member of said blood pump, andwherein a portion of the gas from the gas source is fed to said gas exchanger to provide a gas exchange function.2. The arrangement according to claim 1 , further comprising a blood inlet line connected to the blood inlet on the housing and a blood outlet line connected to the blood inlet on the housing claim 1 , wherein each of the blood inlet line and the blood outlet line include cannulas or tube connections configured to access a patient's blood vessels.3. The arrangement according to claim 2 , wherein the blood inlet line and a blood outlet line each have a length of 80 cm or less.4. The arrangement according to claim 2 , wherein the blood inlet and the blood outlet are arranged on the housing so that the blood inlet line and the blood outlet line are oriented in the same direction.5. The arrangement according to claim ...

ENDOVASCULAR APPARATUS FOR PERFUSING ORGANS IN A BODY

In one representative embodiment, a method of perfusing organs in a patient's body is provided. The method comprises isolating the visceral arteries and the visceral veins from blood circulating through the patient's heart and perfusing the visceral arteries, the visceral veins, and the abdominal organs with a perfusion fluid that is fluidly separated from the blood circulating through the patient's heart. While the visceral arteries and the visceral veins are isolated, and the visceral arteries, the visceral veins, and the abdominal organs are being perfused, the patient's blood is allowed to continue to circulate through the heart. 1. A method of perfusing organs in a patient's body , the method comprising:isolating the visceral arteries and the visceral veins from blood circulating through the patient's heart;perfusing the visceral arteries, the visceral veins, and the abdominal organs with a perfusion fluid that is fluidly separated from the blood circulating through the patient's heart;while the visceral arteries and the visceral veins are isolated and the visceral arteries, the visceral veins, and the abdominal organs are being perfused, allowing the patient's blood to continue to circulate through the heart.2. The method of claim 1 , wherein the act of perfusing the visceral arteries claim 1 , the visceral veins claim 1 , and the abdominal organs comprises establishing a flow of the perfusion fluid that flows into and through an arterial catheter placed in the patient's aorta claim 1 , into and through the visceral arteries claim 1 , the abdominal organs claim 1 , and the visceral veins claim 1 , and into and through a venous catheter placed in the patient's vena cava.3. The method of claim 2 , wherein:isolating the visceral arteries comprises inflating balloons on the arterial catheter to seal the balloons against the aorta wall upstream and downstream of the visceral arteries; andisolating the visceral veins comprises inflating balloons on the venous ...

Partial Radial Heat Exchanger and Oxygenator

Methods of making a combination heat exchanger and oxygenator. A heat transfer tubing is wound about a core and a potting compound is applied to a portion of the wound tubing. The potting compound solidifies to form a potting structure defining an internal face substantially parallel with a longitudinal axis of the core. The assembly is cut along a line passing through the potting structure to define a core assembly having a cut face substantially parallel with the axis. The cut tubing forms a plurality of capillary tubes, each terminating at opposing, first and second ends, and each extending about the core along an arc angle of less than 360 degrees. An oxygenator bundle is formed as part of the core assembly and includes a plurality of gas exchange fibers. The core assembly is disposed within a housing having a blood inlet and a blood outlet. 1. An apparatus for oxygenating and controlling temperature of blood in an extracorporeal circuit , the apparatus comprising:a housing providing a blood inlet and a blood outlet;a core disposed within the housing and defining a longitudinal axis;a heat exchanger bundle including a plurality of heat transfer capillary tubes arranged directly over the core, each of the heat transfer capillary tubes terminating at opposing, first and second ends and extending about the core to define an arc relative to the longitudinal axis, the arc having an arc angle of less than 360 degrees; andan oxygenator bundle including a plurality of gas exchange fibers arranged directly over the heat exchanger bundle;wherein the apparatus is configured to establish a blood flow path from the blood inlet to the blood outlet passing radially through the heat exchanger bundle and the oxygenator bundle.2. The apparatus of claim 1 , further comprising a potting structure encompassing the first end of each of the heat transfer capillary tubes claim 1 , and further wherein a face of the potting structure is arranged in a plane substantially parallel with the ...

METHODS AND SYSTEMS FOR THE DELIVERY OF DISSOLVED GASES AND DE-GASSING MEDICAL FLUID LINES

A method and system for infusing medical liquid with gasses, the system comprising a gas source, a vacuum pump, a temperature-controlled container including a fluid reservoir coupled to the gas source and the vacuum pump, a heating and cooling system, and a sonicator, and a controller configured to de-gas a liquid in the fluid reservoir by activating the vacuum pump, re-gas the liquid in the fluid reservoir by releasing gas from the gas source to the fluid reservoir via a first fluid line, and deliver the re-gassed liquid from the fluid reservoir to a catheter via a second fluid line. 1. A system for infusing medical liquid with gasses , the system comprising:a gas source;a vacuum pump;a temperature-controlled container including a fluid reservoir coupled to the gas source and the vacuum pump, a heating and cooling system, and a sonicator; anda controller configured to:de-gas a liquid in the fluid reservoir by activating the vacuum pump;re-gas the liquid in the fluid reservoir by releasing gas from the gas source to the fluid reservoir via a first fluid line; anddeliver the re-gassed liquid from the fluid reservoir to a catheter via a second fluid line.2. The system of wherein the controller is further configured to de-gas the liquid in the fluid reservoir by enabling the heating and cooling system to heat the fluid reservoir claim 1 , and activating the sonicator to sonificate the fluid reservoir.3. The system of wherein the controller is further configured to re-gas the liquid in the fluid reservoir by enabling the heating and cooling system to cool the fluid reservoir claim 1 , and activating the sonicator to sonificate the fluid reservoir.4. The system of wherein the gas comprises a gas selected from the group consisting of oxygen claim 1 , carbon dioxide claim 1 , and nitric oxide.5. The system of further comprising sensors to detect bubbles claim 1 , gas concentration claim 1 , and temperature of the liquid.6. The system of further comprising a device that ...

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

The present disclosure provides a system for oxygenating blood. The system may include an implantable blood pump that may draw a supply of blood from the circulatory system of a mammalian subject, such as a human being. The blood pump may provide the supply of blood to an adaptor, where the supply of blood may be supplied to either or both of a first branch or second branch. The first branch may lead to an external blood oxygenator. The oxygenator may oxygenate the blood, and the blood may be returned to the circulatory system of the mammalian subject. The second branch may bypass the oxygenator and may connect to the circulatory system of the mammalian subject. In this regard, while the blood is supplied to the second branch, the oxygenator may be disconnected and blood may be prevented from entering the first branch. 1. A portable lung assist system comprising:(a) a blood pump, wherein the blood pump has an outlet and an inlet adapted for communication with the circulatory system of a mammalian subject at an inlet location, and wherein the blood pump can be carried by a subject;(b) one or more return fittings adapted for communication with the circulatory system of the subject at one or more return locations remote from the inlet location;(c) an external, portable blood oxygenator having a blood inlet releasably connectable and which is in communication with the outlet of the pump and a blood outlet releasably connectable with one of said return fittings; and(d) a bypass conduit adapted to connect the outlet of the blood pump in communication with one of said return fittings at least when the oxygenator is disconnected, wherein the portable lung assist system supplements the action of the subject's lungs.2. The system of further comprising a blood oxygenator inlet disconnect fitting which is releasably connectable to the outlet of the blood pump and an oxygenator outlet disconnect fitting which is releasably connectable to one of said return fittings claim 1 , the ...

ISOLATING CARDIAC CIRCULATION

In a method for substantially isolating cardiac circulation from systemic circulation, flow between the coronary sinus and the right atrium is occluded. A venous collection device having a collection lumen and a support structure is located in the coronary sinus. The support structure is used to maintain patency of the coronary sinus during collection of fluid through the collection lumen. An artificial flow path is provided between the collection lumen and the one or more coronary arteries, thus isolating the cardiac circulation. According to the method, cardiac pumping for systemic circulation can be maintained during isolation of the cardiac circulation. 158-. (canceled)59. A system comprising: a) a collection lumen comprising a centralized tip;', 'b) a first occluding structure located substantially around the collection lumen and adapted to, when activated, rest in abutment with a portion of the right atrium wall surrounding the coronary sinus;', 'c) a second occluding structure positioned distally to the first occluding structure, wherein the collection lumen extends through the second occluding structure, wherein the second occluding structure is configured to, when activated, occlude flow between the coronary sinus and the right atrium, whilst allowing collection of fluid from the coronary sinus through the centralized tip of the collection lumen; and', 'd) an expandable support structure locatable inside the coronary sinus and configured to maintain patency of the sinus during collection of fluid therefrom, wherein the expandable support structure is physically reducible for percutaneous delivery to the coronary sinus, and slidably disposed within the collection lumen, and wherein the expandable support structure is manipulatable by a wire element passing through the collection lumen; and, '1) an isolation apparatus for isolating cardiac venous circulation during collection of fluid therefrom, the isolation apparatus comprising2) a delivery device ...

Systems and Methods for Treating Blood

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees. 1. A system comprising:one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters minute;one or more heat exchangers coupled to the fluid flow path and operable to heat at least some of the blood to a temperature of at least 42 degrees Celsius and operable to allow at least some of the blood to cool one or more degrees, following the heating of at least some of the blood to a temperature of at least 42 degrees Celsius; andone or more convection dialysis modules coupled to the fluid flow path and configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees, the one or more convection dialysis modules configured to remove substances from the blood that are over 3500 Daltons in size.2. The system of claim 1 , wherein the one or more heat exchangers are configured to heat at least some of the blood to a temperature between 42.5 and 45 degrees Celsius.3. The system of claim 1 , wherein the one or more heat exchangers are configured to heat at least some of the blood to a temperature between 42 and 44.5 degrees Celsius.4. The system of claim 1 , wherein the one or more heat exchangers are configured to heat at least some of the blood to a temperature of at least 42.5 ...

CPB System With Dual Function Blood Reservoir

The venous reservoir is omitted from an extracorporeal blood circuit system by substituting a blood reservoir in parallel with the arterial pump. The reservoir has an inlet connected to the outlet of the pump and an outlet connected to the inlet of the pump. At least three blood flow paths can be configured. A main path has the inlet and outlet of the reservoir blocked while pumped blood flows through the venous cannula, the oxygenator, and the arterial cannula. An accumulator path has the inlet to the oxygenator and the outlet of the reservoir blocked while blood flows through the venous cannula and the inlet to the reservoir. A discharge path has the inlet of the reservoir blocked while the outlet is open whereby blood from the reservoir flows into the oxygenator. In a fourth configuration, the ECC fluid can be recovered in the reservoir and hemoconcentrated for autologous transfusion. 1. An extracorporeal blood circuit system (ECC) for use on a patient , comprisinga venous cannula line having an inlet and an outlet;an oxygenator in fluid communication with the outlet of the venous cannula line, having an inlet for receiving oxygen deficient blood and an outlet for oxygenated blood;an arterial cannula line having an inlet in fluid communication with the outlet of the oxygenator and an outlet for delivering oxygenated blood;a pump having an inlet connected to the outlet of the venous line and an outlet connected to an inlet line of the oxygenator, for inducing blood flow through the venous cannula line, oxygenator, and arterial cannula line;a blood reservoir having an inlet line connected to the outlet of the pump and an outlet line connected to the inlet of the pump; a main path in which the inlet and outlet lines of the blood reservoir are blocked while pumped blood flows through the venous cannula line, the oxygenator, and the arterial cannula line,', 'an accumulator path in which the inlet to the oxygenator and the outlet line of the blood reservoir are blocked ...

CPB System With Fluid Volume Control

In an extracorporeal blood circuit system or a machine configurable in such a circuit, a bag blood reservoir has an infusion port at the upper end of the bag, an outlet port at the lower end of the bag, an inlet port at the lower end of the bag, and an IV port at the lower end of the bag. A split line is connected to the infusion port, having a first branch line connected to a source makeup fluid into the reservoir and a second branch line that evacuates from the reservoir. An air detector and a vent controller automatically configure a venting path in which the inlet lines to the pump and to the blood reservoir are open such that air rises to the upper end of the blood reservoir from which it can be vented through the infusion port into the air evacuation line. 1. An extracorporeal blood circuit system (ECC) for use on a patient , comprisinga venous cannula line having an inlet and an outlet;an oxygenator in fluid communication with the outlet of the venous cannula line, having an inlet for receiving oxygen deficient blood and an outlet for oxygenated blood;an arterial cannula line having an inlet in fluid communication with the outlet of the oxygenator and an outlet for delivering oxygenated blood;a pump having an inlet connected to the outlet of the venous cannula line and an outlet connected to an inlet line of the oxygenator, for inducing blood flow through the venous cannula line, oxygenator, and arterial cannula line;a closed bag blood reservoir of substantially transparent, bio-compatible material, having upper and lower ends, an infusion port and connector located at the upper end of the bag, an outlet port and connector located at the lower end of the bag, an inlet port and connector located at the lower end of the bag, and an IV port and connector located at the lower end of the bag;a reservoir inlet line between the outlet of the pump and the inlet port connector and a reservoir outlet line between the inlet of the pump and the outlet port connector;a ...

CPB Pump System With Double Y Tubing

A system and associated tubing set for installation on the panel of extracorporeal circuit, including a pump tubing unit featuring a disposable pump. Two inlet line branches are fluidly connected to the pump inlet and two outlet line branches are fluidly connected to the pump outlet. The free ends of one inlet branch and one outlet branch carry a Colder type connector and a clamp between the pump and the respective Colder connectors. A blood reservoir unit has a support plate mountable to the panel, which carries a blood bag having an inlet line with a free end and Colder connector and an outlet line with free end and Colder connector. 1. A disposable pump tubing set for an extracorporeal blood circulation system (ECC) , comprising at least a portion of a blood pump , said pump portion having an inlet side with two inlet side tubing branches and an outlet side with two outlet side tubing branches.2. The disposable pump tubing set of claim 1 , wherein the inlet side branches are fluidly connected to the pump by a common inlet side tube and the outlet side branches are fluidly connected to the pump by a common outlet side tube.3. The disposable pump tubing set of claim 1 , wherein each branch carries a clamp.4. The disposable pump tubing set of claim 1 , whereinone inlet side branch has a free end that carries a Colder connector and one outlet side branch has a free end that carries a Colder connector;the other inlet side branch and the other outlet side branch each has a free end that carries a ¼ or ⅜ inch connector; andeach tube passes through a clamp between the pump and the respective connectors.5. A system for installation on an extracorporeal blood circuit claim 1 , comprising:a panel;a pump having an inlet side attachable to a system inlet line for the pump to receive blood from a patient and an outlet side attachable to a system outlet line for the pump to deliver blood to the patient;a tubing unit including two inlet side branches fluidly connected to the ...

APPARATUS FOR MAKING EXTRACORPOREAL BLOOD CIRCULATION AVAILABLE

The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of aft bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus. 1. An apparatus for making extracorporeal blood circulation available , in particular a heart-lung machine , comprising a venous connection and an arterial connection , between which a blood reservoir , a blood pump and a bubble detector for the detection of air bubbles are provided , with , downstream of the bubble detector , an arterial line leading to the arterial connection via an arterial damp and a bypass leading via a bypass damp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir.2. An apparatus in accordance with claim 1 , wherein at least one of an oxygenator and an arterial filter is provided between the blood pump and the bubble detector.3. An apparatus in accordance with claim 1 , wherein blood-conducting components of the apparatus claim 1 , in particular at least one of an oxygenator and an arterial filter claim 1 , are connected to the blood reservoir via a venting line claim 1 , with venting clamps being respectively provided between the blood-conducting components and the blood reservoir for the closing of the venting line.4. An apparatus in accordance with claim 1 , wherein the blood pump is made as a centrifugal pump with a central inlet and a tangential outlet claim 1 , with the tangential outlet facing downwardly when the apparatus is in an operating ...

EXTRACORPOREAL CIRCULATION DEVICE

An extracorporeal blood circulator includes a control unit and a speed manipulation section. A rotation display section displays a lower limit rotation setting value of a pump motor in accordance with a command of the control unit. The lower limit rotation speed setting value is a minimum rotation speed for preventing backflow of blood inside a circulation circuit A manually adjusted speed setting request from the manipulation section controls the pump speed, except that the controller enforces the lower limit speed setting unless receiving confirmation from a manipulator. 1. An extracorporeal circulator driven by a rotation drive unit to circulate blood of a patient outside a body , the extracorporeal circulator comprising:a control unit coupled to the rotation drive unit to control an actual rotation speed of the rotation drive unit;a manipulation section coupled to the control unit to manually adjust a speed setting request provided to the control unit, wherein the control unit controls the rotation speed of the rotation drive unit subject to a lower limit rotation speed setting value; anda rotation speed display section that displays the lower limit rotation setting value of the rotation drive unit in accordance with a command of the control unit,wherein the lower limit rotation speed setting value is a minimum rotation speed for preventing backflow of the blood inside the circulator so as to operate the rotation drive unit and to cause the blood to return to an inside of the body of the patient.2. The extracorporeal circulator according to claim 1 ,wherein after a rotation speed of the rotation drive unit is raised above the lower limit rotation speed setting value, the control unit causes the display section to display a confirmation message in response to a manually adjusted speed setting request at or below the lower limit rotation speed setting value.3. The extracorporeal circulator according to claim 2 ,wherein when the confirmation message displayed by ...

SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS AND ARTERIES

A system and method for increasing the speed of blood and the wall shear stress in a peripheral artery or peripheral vein to a sufficient level and for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the artery or vein is provided. The method includes systems and methods to effect the movement of blood at the desired rate and in the desired direction. The movement of blood is monitored and adjusted, as necessary, to maintain the desired blood speed and wall shear stress in the peripheral artery or vein in order to optimize the rate and extent of persistent diameter increase of the peripheral artery or peripheral vein. 1225-. (canceled)226. A method for increasing an overall diameter and a lumen diameter of a donating artery of a patient comprising:fluidly connecting one end of a pump-conduit assembly to the donating artery;fluidly connecting another end of the pump-conduit assembly to an accepting location; and,pumping oxygenated blood from the donating artery into the accepting location at a flow rate, and for a time, sufficient to result in a persistent increase in the overall diameter and the lumen diameter of the donating artery.227. The method of further comprising:using at least a portion of the donating artery with the persistently-increased overall diameter and lumen diameter to create an arteriovenous fistula, an arteriovenous graft, or a bypass graft in the patient.228. The method of claim 226 , wherein the pump-conduit assembly pumps blood at a rate between 100 ml/min and 1000 ml/min.229. The method of claim 226 , wherein a mean wall shear stress in the donating artery is between 1.5 Pa and 23 Pa when the pump-conduit assembly is in operation.230. The method of claim 226 , wherein a mean speed of the blood in the donating artery is between 10 cm/s and 120 cm/s when the pump-conduit assembly is in operation.231. The method of claim 226 , wherein blood is pumped through the pump-conduit assembly ...

Method for bubble-free gas-enrichment of a flowing liquid within a conduit

The present invention provides a system for enriching a flowing liquid with a dissolved gas inside a conduit. The system comprises two or more capillaries, each capillary delivering a stream of a gas-enriched liquid to the flowing liquid. The first ends of the capillaries are positioned to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the larger liquid conduit before these gas-enriched streams are able to come into close contact with the boundary surfaces of the conduit, whereby the gas-enriched liquid mixes with the flowing liquid to form a gas-enriched flowing liquid. In the preferred embodiment, no observable bubbles are formed in the gas-enriched flowing liquid. Methods of making and using such system are also provided. 116- (canceled)17. A method of assembling a system for enriching a flowing liquid inside a conduit with a gas-enriched liquid , the method comprising:(a) providing two or more capillaries each having the first and second ends for delivery of a gas-enriched liquid; wherein an effluent stream exits from the first end of each capillary;(b) positioning the first ends of the capillaries to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the conduit before the streams come into close contact with the boundary surfaces of the conduit; and(c) operatively connecting second ends of the capillaries to a source of the gas-enriched liquid.18. The method of claim 17 , wherein the step (a) further comprises:(a1) providing a single lumen capillary tube;(a2) wrapping the tube around a curved tool with a known radius to form a capillary of a modified shape having a curved segment; and(a3) cutting and ...

Physiologic cardiovascular ph balanced counter current electrolyte transfer and fluid removal system

Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patients blood using a counter current electrolyte solution.

HEART LUNG MACHINE CONNECTION SYSTEM

A connection assembly is configured to facilitate connecting at least one heart lung machine (HLM) component to an HLM base. The connection assembly includes a mounting bracket having a connection interface configured to facilitate coupling the connection assembly to at least one of the HLM base and a mast of the HLM. The mast is coupled to the HLM base. A component connector is configured to facilitate removably connecting an HLM component to the HLM base. 1. A connection assembly configured to facilitate connecting at least one heart lung machine (HLM) component to an HLM base , the connection assembly comprising:a mounting bracket comprising a connection interface configured to facilitate coupling the connection assembly to at least one of the HLM base and a mast of the HLM, wherein the mast is coupled to the HLM base; anda component connector configured to facilitate removably connecting an HLM component to the HLM base.2. The connection assembly of claim 1 , the connection interface comprising a mast interface claim 1 , the mast interface comprising at least one of a swiveling mast insert and a quick-connect mast holder.3. The connection assembly of claim 1 , the component connector comprising at least one of a fluid connection element claim 1 , an energy connection element claim 1 , and a data connection element.4. The connection assembly of claim 1 , the component connector further comprising an engagement mechanism.5. The connection assembly of claim 4 , further comprising a component support claim 4 , the component support comprising:a component mount configured to be coupled to the HLM component; anda support arm coupled, at a first end, to the component mount, and extending away from the component mount, wherein a second end of the support arm is configured to be releasably engaged by the engagement mechanism of the component connector.6. The connection assembly of claim 5 , the component support further comprising one or more illuminating elements ...

System and method for cardiopulmonary bypass using hypobaric oxygenation

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a sub atmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the sub atmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

OXYGENATOR WITH A HOUSING WALL

An oxygenator with a housing wall, which delimits a housing space with a blood inlet and a blood outlet, a gas inlet and a gas outlet, has a heating element which is arranged in the oxygenator between blood inlet and blood outlet in order to control the temperature of blood flowing through the housing space. For this purpose, the oxygenator has a radiation source and a receiver. The radiation source can be an infrared emitter and the receiver a matte-black surface, or the radiation source is an induction coil and the receiver has a material capable of induction. In a method for regulating the heat output on a heating element of an oxygenator, the through-flow of the blood through the oxygenator and the power of a pump acting on the through-flow are measured, and the heating power is adjusted in accordance therewith. 29131010. A method for regulating the heat output at a heating element () of an oxygenator () , in which the flow of blood through the oxygenator () or the power of a pump governing the through-flow are measured , and the heating power is adjusted in accordance therewith. The invention concerns an oxygenator with a housing wall that delimits a housing space with a blood inlet, a blood outlet, a gas inlet and a gas outlet, and a heating element to control the temperature of the blood flowing through the housing space.Oxygenators are medical gas exchangers that are mainly used in cardiopulmonary therapies lasting several days or during operations. Another application, for example, is dialysis. In addition to gas exchange, these oxygenators often also offer the possibility of controlling the temperature of the blood flowing through a housing space of the oxygenator. As a rule, the blood in the oxygenator is heated because the blood temperature in the extracorporeal circulation, that is to say, outside the patient's body, decreases over time and the patient becomes hypothermic. In addition to this heating, it is also possible to cool the blood temperature ...

Systems And Methods For Treating Blood

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

INTRACORPOREAL ARTIFICIAL LUNG

The present invention describes a new artificial lung inserted within the human chest. The principles governing functionality of this device are gravity dependent rotation and separation of the oxygen from circulatory system by gravity, different diameters of pores on the oxygen tube with angled channels in the vertical mesh septum and incorporation of one-way valves. Other advantages of the design: it does not contain porous fibers and its inherent resilience and capacitance may play decisive role in long-term management of patients with respiratory failure and substituting need for lung transplants. Moreover, the design has a relatively small prime blood volume and takes into consideration prevention of right ventricular strain by maintaining pulmonary arterial pressure within the physiologic range. It's placement within pulmonary circulation in parallel anastomosis is considered to be least stressful for the heart. The relative simplicity of the device to prior art is another striking advantage. 21. The artificial lung of claim device is coated with anti-adhesive film/surface like Teflon to prevent blood from fibrin/thrombosis formation within the device.31. The artificial lung device of claim wherein said external cover having at least one hole.41. The artificial lung device of claim wherein said horizontal septum having at least one hole located above said vertical inter chamber septum in said working chamber.51. The artificial lung device of claim wherein said vertical inter chamber septum extents from the bottom of said working chamber to the said horizontal septum and separates said blood and said oxygen chambers.51. The artificial lung device of claim wherein said vertical septum having channels coursing at a 45 degree angle to the vertical axis of the septum having the higher points of the channels open to said oxygen chamber and the lower points of said channels open to said blood chamber.71. The artificial lung device of claim wherein said pulmonary tube ...

EXTRACORPOREAL CIRCUIT FOR CO2 REMOVAL FROM BLOOD

The present invention relates to an extracorporeal circuit for COremoval from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and in that wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane. 1. An extracorporeal circuit for COremoval from blood comprising:a line for taking blood from the patient; a first filtering unit;', 'an oxygenator;', 'an electrodialyzer adapted to generate an acid solution and a basic solution; and', 'a means for the infusion of said acid solution upstream of said oxygenator; and, 'a decarboxylation assembly, comprisinga line for returning the blood to the patient wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and wherein said first chamber and said second chamber are respectively separated from a positive electrode, or anode, and from a negative electrode, or cathode, by means of a bipolar membrane.2. An extracorporeal circuit for COremoval from blood according to claim 1 , wherein said first filtering unit is a filter selected in the group consisting of a haemodiafilter claim 1 , a haemofilter and a dialyzer.3. An extracorporeal circuit for COremoval from blood according to claim 1 , further comprising a precipitate removal unit arranged upstream of ...

System and methods for ventilation through a body cavity

A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles. Through circulation of oxygen microbubbles through the body cavity, oxygen and carbon dioxide exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen-intake restricting injury and/or failure may be achieved through use of the invented system and methods.

EXTRACORPOREAL CIRCUIT FOR REMOVAL OF CO2 FROM BLOOD

The present invention concerns an extracorporeal circuit for removing COfrom blood comprising a blood withdrawal line for withdrawing blood from the patient, a filtration unit for producing plasma water and a line for returning the blood to the patient, defining a main circuit; the extracorporeal circuit further comprises a decarbonating group comprising a secondary circuit for the recirculation of plasma water, means for removing a fraction of said plasma water, a COexchanger, a cationic resin charged with H+ ions set upstream of the COexchanger and adapted to generate acid plasma water, means for the infusion of the acid plasma water upstream of the COexchanger and means for the infusion of ions in a solution downstream of the COexchanger. 11100200300400500263054047123091093015309119aa. An extracorporeal circuit ( , , , , , ) for removing COfrom blood comprising a blood withdrawal line () for withdrawing blood from a patient , a filtration unit () for producing plasma water () and a line for returning the blood () to the patient , defining a main circuit (); said extracorporeal circuit being characterised in that it comprises a decarbonating group () comprising a secondary circuit () for recirculation of plasma water , means () for removing a fraction of said plasma water () , a COexchanger () , a cationic resin charged with H+ ions () set upstream of said COexchanger () and adapted to generate acid plasma water () , means () for infusion of said acid plasma water () upstream of said COexchanger () and means () for infusion of ions in a solution downstream of said COexchanger ().26. The extracorporeal circuit according to claim 1 , characterised in that said filtration unit () is a filter selected from the group consisting of a haemodialysis filter claim 1 , a haemofilter and a dialyser.3. The extracorporeal circuit according to claim 1 , characterised in that said cationic resin charged with H+ ions is selected from the group consisting of a cationic resin ...

Method for Bubble-Free Gas-Enrichment of a Flowing Liquid within a Conduit

The present invention provides a system for enriching a flowing liquid with a dissolved gas inside a conduit. The system comprises two or more capillaries, each capillary delivering a stream of a gas-enriched liquid to the flowing liquid. The first ends of the capillaries are positioned to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the larger liquid conduit before these gas-enriched streams are able to come into close contact with the boundary surfaces of the conduit, whereby the gas-enriched liquid mixes with the flowing liquid to form a gas-enriched flowing liquid. In the preferred embodiment, no observable bubbles are formed in the gas-enriched flowing liquid. Methods of making and using such system are also provided.

TELESCOPING NEUROVASCULAR CATHETER WITH ACTIVE DISTAL TIP

A telescoping catheter is provided such as for distal neurovascular aspiration or access. The catheter includes an elongate, flexible tubular body, having a proximal section with at least one lumen and a distal section which is axially movably positioned within the lumen. A control is provided for advancing the distal section from a first, proximally retracted position within the proximal section to a second extended position, extending distally beyond the proximal section. The distal end of at least one of the proximal and distal sections may be provided with at least one active feature, such as at least one movable jaw or rotatable agitator, to assist in the capture of vascular obstruction. The jaw may be operable in response to application of pulsatile negative pressure through the catheter. 1. A telescoping catheter , comprising:an elongate, flexible tubular body, comprising a proximal section having at least one lumen and a distal section axially movably positioned within the lumen; anda control for advancing the distal section from a first, proximally retracted position within the proximal section to a second, extended position, extending distally beyond the proximal section; andan active tip on the distal end of the distal section, comprising a distal opening that is movable between a smaller and a larger configuration.2. A telescoping catheter as in claim 1 , wherein the control comprises a pull wire extending through the proximal section.3. A telescoping catheter as in claim 1 , wherein the distal section is distally advanceable to extend beyond the proximal section for a distance of at least about 10 cm.4. A telescoping catheter as in claim 1 , wherein the distal section is distally advanceable to extend beyond the proximal section for a distance of at least about 25 cm.5. A telescoping catheter as in claim 1 , wherein the distal opening is movable in response to movement of a control wire.6. A telescoping catheter as in claim 1 , wherein the distal ...

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

Dual-Pump Continuous-Flow Total Artificial Heart

A total artificial heart for a mammalian cardiovascular system is provided. The total artificial heart has a pump casing including an outer housing and an integral hollow support shaft extending therethrough. The casing defines a first flow path within the outer housing about an exterior of the hollow support shaft and a separate second flow path extending within the hollow support shaft. An annular impeller is housed within the outer housing of the casing for rotation about the hollow support shaft to provide a centrifugal flow pump in the first flow path, and an axial flow impeller is housed within the hollow support shaft of the casing for forming an axial flow pump in the second flow path. 1. A pump , comprising:a centrifugal flow pump having an annular impeller with a central opening; andan axial flow pump having an axial flow impeller;said axial flow pump being integrated with said centrifugal flow pump such that said axial flow pump extends through said central opening of said annular impeller of said centrifugal flow pump.2. A pump according to claim 1 , wherein said axial flow impeller of said axial flow pump is positioned to extend within said central opening of said annular impeller of said centrifugal flow pump.3. A pump according to claim 1 , wherein an axis of rotation of said axial flow impeller of said axial flow pump is parallel or tilted at an angle of less than about 5° relative to an axis of rotation of said annular impeller of said centrifugal flow pump.4. A pump according to claim 1 , wherein said annular impeller of said centrifugal flow pump and said axial flow impeller of said axial flow pump each rotate about a common axis of rotation.5. A pump according to claim 1 , further comprising a casing for housing said annular impeller of said centrifugal flow pump claim 1 , wherein said casing includes a hollow support shaft extending through said central opening of said annular impeller of said centrifugal flow pump about which said annular ...

ENDOVASCULAR APPARATUS FOR PERFUSING ORGANS IN A BODY

In one representative embodiment, a method of perfusing organs in a patient's body is provided. The method comprises isolating the visceral arteries and the visceral veins from blood circulating through the patient's heart and perfusing the visceral arteries, the visceral veins, and the abdominal organs with a perfusion fluid that is fluidly separated from the blood circulating through the patient's heart. While the visceral arteries and the visceral veins are isolated, and the visceral arteries, the visceral veins, and the abdominal organs are being perfused, the patient's blood is allowed to continue to circulate through the heart. 1. A perfusion stent implantable within a body lumen , the stent comprising:a radially compressible and expandable, elongated body comprising first and second end portions and an intermediate portion extending from the first end portion to the second end portion;the first and second end portions having an outer diameter greater than an outer diameter of the intermediate portion when the body is in a radially expanded state, thereby defining an annular perfusion space between the first and second end portions and around the intermediate portion;a central lumen extending through the first end portion, the intermediate portion, and the second end portion; anda perfusion lumen extending at least partially through the first end portion and having a distal opening in communication with the perfusion space;wherein when the elongated body is in the radially expanded state within the body lumen and the first and second end portions are engaged with an inner wall of the body lumen, the central lumen is fluidly separated from the perfusion space.2. The perfusion stent of claim 1 , further comprising a perfusion conduit extending at least partially through the first end portion claim 1 , the perfusion conduit defining the perfusion lumen.3. The perfusion stent of claim 1 , wherein the body comprises an inlet and an outlet of the central lumen and a ...

Device having an artificial gills system and use thereof for supporting a newborn

A device and a method for supporting a human being, preferably a premature infant between the 21/0 and 28/0 week of pregnancy (SSW), The device comprises at least one through-flow system, comprising a number of fluid-permeable elements and connecting elements for the connection to an umbilical arterial catheter and an umbilical. venous catheter and a through-flow lumen for passing modified amniotic fluid enriched with oxygen or an oxygen-containing gas mixture through the fluid-permeable elements, and at least one connection for introducing the modified amniotic fluid into the through-flow system. The through-flow systema is configured in such a way that the modified amniotic fluid is guided through the fluid-permeable elements of the through-flow system while the fetal blood is passed along the outer side of the fluid-permeable elements, but directed past the through-flow lumen, whereby a gas exchange occurs. 1212226283032202212212122212220. A device for the life support of a newborn , in particular of an extremely premature infant between the 21/0 and 28/0 weeks of gestation (WG) , comprising at least one flow-through system () comprising a number of fluid-permeable elements () and connecting elements ( , ) configured for connection to the umbilical artery catheter () and umbilical vein catheter () of the newborn , and a flow-through lumen () for passing modified amniotic fluid enriched with oxygen or an oxygen-containing gas mixture through the fluid-permeable elements () , and at least one connection () for introducing the oxygen- or oxygen-containing gas mixture-enriched modified amniotic fluid into the flow-through system () , wherein the flow-through system () is configured to pass the oxygen- or oxygen-containing gas mixture-enriched modified amniotic fluid through the fluid-permeable elements () of the flow-through system () while passing the fetal blood past the outside of the fluid-permeable elements () via the flow-through lumen () , whereby gas exchange ...

Device with a fluid pump, at least two points of access to the abdominal wall and tubes connecting the fluid pump and abdominal wall

A device with a blood pump, at least two points of access to the abdominal wall and tubes connecting the blood pump and points of access to the abdominal wall, which is known as a peritoneal dialysis system, is equipped with a CO 2 removal arrangement, in order to use it tor blood oxygenation and/or CO 2 removal.

EXTRACORPOREAL PHOTODYNAMIC BLOOD ILLUMINATION (IRRADIATION) FOR THE TREATMENT OF CARBON MONOXIDE POISONING

Treatment of carbon monoxide poisoning of a body by removal of a portion of the blood from the body, placing the portion in an exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The intensity and wave length of the light is sufficient to dissociate a therapeutically-effective amount of carbon monoxide from the hemoglobin in the blood. The blood is circulated from and to the body through a concentric double lumen cannula. The wave lengths of the light are 540 and/or 570 nanometers. The cell exposes the blood to at least 9.5 Joules of dissociative light per milliliter of blood, and least 9.5 Watts of dissociative light per milliliter of blood per second. Oxygen is provided to, and the dissociated carbon monoxide is removed from the system. 1. A system for treatment of carbon monoxide poisoning of the blood of a living victim , comprising:a. an exposure cell,b. a first sub-system adapted to remove a portion of the blood from the victim and to place the portion in the exposure cell,c. a second sub-system adapted to expose the portion in the cell to dissociative light that causes dissociation of carbon monoxide from hemoglobin, andd. a third sub-system adapted to return the portion to the victim.2. A system as recited in claim 1 , wherein the dissociative light is of a wave length selected from the group of 540 and 570 nanometers and combinations thereof.3. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Joules per milliliter of blood.4. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Watts per milliliter of blood flow per second.5. A system as recited in claim 1 , wherein the first and third sub-systems are a concentric double lumen cannula.6. A system as recited in claim 1 , wherein the system includes a subsystem that injects oxygen into ...

EXTRACORPOREAL CIRCULATION MANAGEMENT DEVICE AND EXTRACORPOREAL CIRCULATION DEVICE HAVING IT

An extracorporeal blood circulation management device having an oxygenator accurately determines oxygen consumption by the target person and oxygen delivery by the oxygenator. Oxygenation-related parameter values in the blood are determined at regular intervals. An in-body passing time (a cycle time for a particular volume of blood to pass from input sensors to output sensors) is determined. Parameter values separated by the in-body passing time are selected as comparison targets to evaluate oxygenation consumption of the target person. An oxygenator unit passing time is determined. Parameter values separated by the oxygenator unit passing time are selected as comparison targets to evaluate oxygenation delivery of the oxygenation unit. 1. An extracorporeal circulation management device comprising:means for storing a plurality of first oxygenation-related parameter values of blood supplied from an output of an oxygenator unit that carries out gas exchange of blood to a target person with time-course information and for storing a plurality of second oxygenation-related parameter values of blood introduced from the target person into an input of the oxygenator unit with time-course information;means for storing in-body passing time information defining a time period for blood supplied from the output of the oxygenator unit to the target person to be discharged from the target person; andmeans for selecting first oxygenation-related parameter values separated by the stored in-body passing time and for selecting second oxygenation-related parameter values separated by the stored in-body passing time as comparison targets to evaluate oxygenation consumption of the target person.2. The extracorporeal circulation management device according to claim 1 , wherein the in-body passing time information is corrected according to locations on the target person where the blood is introduced from the oxygenator unit into the target person and where the blood is discharged from the ...

EXTRACORPOREAL PHOTODYNAMIC BLOOD ILLUMINATION (IRRADIATION) FOR THE TREATMENT OF CARBON MONOXIDE POISONING

Treatment of carbon monoxide poisoning of a body by removal of a portion of the blood from the body, placing the portion in an exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The intensity and wave length of the light is sufficient to dissociate a therapeutically-effective amount of carbon monoxide from the hemoglobin in the blood. The blood is circulated from and to the body through a concentric double lumen cannula. The wave lengths of the light are 540 and/or 570 nanometers. The cell exposes the blood to at least 9.5 Joules of dissociative light per milliliter of blood, and least 9.5 Watts of dissociative light per milliliter of blood per second. Oxygen is provided to, and the dissociated carbon monoxide is removed from the system. 1. A system for treatment of carbon monoxide poisoning of the blood of a living victim , comprising:a. an exposure cell,b. a first sub-system adapted to remove a portion of the blood from the victim and to place the portion in the exposure cell,c. a second sub-system adapted to expose the portion in the cell to dissociative light that causes dissociation of carbon monoxide from hemoglobin, andd. a third sub-system adapted to return the portion to the victim.2. A system as recited in claim 1 , wherein the dissociative light is of a wave length selected from the group of 540 and 570 nanometers and combinations thereof.3. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Joules per milliliter of blood.4. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Watts per milliliter of blood flow per second.5. A system as recited in claim 1 , wherein the first and third sub-systems are a concentric double lumen cannula.6. A system as recited in claim 1 , wherein the system includes a subsystem that injects oxygen into ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; andan oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart within the body, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.2. (canceled)3. The implantable heart treatment device of claim 1 , wherein the oxygenator includes a reservoir configured to store the one or more oxygenated molecules.4. The implantable heart ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body;a metabolic molecule supply device coupled to the substrate and configured to supply one or more metabolic molecules to one or more tissues of the heart within the body; andcontrol circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals upon execution of the first control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals and to generate one or more control signals that cause the metabolic molecule supply device to supply the one or more ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; andan energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.2. The implantable heart treatment device of claim 1 , wherein the one or more non-oxygen cellular energy sources include at least one of adenosine triphosphate (ATP) claim 1 , cyclic adenosine monophosphate (cAMP) claim 1 , adenosine monophosphate (AMP) claim 1 , adenosine diphosphate (ADP) claim 1 , creatine claim 1 , and cyclocreatine.36.-. (canceled)7. The implantable heart treatment device of claim 1 , wherein the energy-carrier molecule delivery device includes a reservoir configured to store the one or more non-oxygen cellular energy sources molecules.8. The implantable heart treatment device of claim 1 , wherein the one or more non-oxygen cellular energy sources are positioned within one or more carrier molecules.911.-. (canceled)12. The implantable heart treatment device of claim 8 , wherein the one or more carrier molecules include at least one targeting agent configured to target cardiac tissue.13. ( ...

SYSTEM AND METHOD FOR CARDIOPULMONARY BYPASS USING HYPOBARIC OXYGENATION

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir. 1. A system for cardiopulmonary bypass , the system comprising:an oxygen source comprising a pressure regulator configured to regulate an oxygen pressure;an oxygenator fluidly connected to the pressure regulator of the oxygen source via a sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood;a vacuum regulator fluidly connected to the oxygenator via a sweep gas outlet, and configured to provide the subatmospheric pressure; anda flow restrictor fluidly connected to the sweep gas inlet and configured to provide a pressure drop from the oxygen source to the oxygenator.2. The system of claim 1 , further comprising a positive pressure relief valve fluidly connected to the sweep gas outlet.3. The system of claim 1 , wherein the oxygenator is a membrane oxygenator having a sealed housing.4. The system of claim 1 , further comprising an arterial filter fluidly connected to a blood outlet of the oxygenator.5. The system of claim 4 , further ...

Blood oxygenator

The present disclosure describes a blood oxygenator that includes a checkerboard layout of fluid (e.g., blood) and gas (e.g., oxygen) channels. When viewed as a cross-section through each of the channels of the oxygenator, the checkerboard configuration includes alternating gas and fluid channels in both the x-axis (e.g., in-plane) and in the y-axis (e.g., out-of-plane) directions. The oxygenator described herein reduces manufacturing complexity by using first, second, and third polymer layers that include asymmetrical channel designs. The channel designs include “open” gas channels, which are exposed to the ambient atmosphere. The oxygenator is placed within a pressure vessel to drive gas into each of the open gas channels, which in some implementations, negates the need for a gas manifold.

EXTRACORPOREAL AMBULATOR ASSIST LUNG

A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing. 1. A extracorporeal system for lung assist comprising:a housing,a blood flow inlet in fluid connection with the housing;a blood flow outlet in fluid connection with the housing;a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet, the plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the housing;a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers;a gas outlet in fluid connection with ...

SYSTEM AND METHOD FOR CARDIOPULMONARY BYPASS USING HYPOBARIC OXYGENATION

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir. 1. A system for cardiopulmonary bypass , the system comprising:an oxygen source comprising a pressure regulator configured to regulate an oxygen pressure;an oxygenator fluidly connected to the pressure regulator of the oxygen source via a sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood;a vacuum regulator fluidly connected to the oxygenator via a sweep gas outlet, and configured to provide the subatmospheric pressure; anda flow restrictor fluidly connected to the sweep gas inlet and configured to provide a pressure drop from the oxygen source to the oxygenator.2. The system of claim 1 , further comprising a positive pressure relief valve fluidly connected to the sweep gas outlet.3. The system of claim 1 , wherein the oxygenator is a membrane oxygenator having a sealed housing.4. The system of claim 1 , further comprising an arterial filter fluidly connected to a blood outlet of the oxygenator.5. The system of claim 4 , further ...

Method and apparatus for mitigating acute reoxygenation injury during percutaneous coronary intervention

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

The present disclosure provides a system for oxygenating blood. The system may include an implantable blood pump that may draw a supply of blood from the circulatory system of a mammalian subject, such as a human being. The blood pump may provide the supply of blood to an adaptor, where the supply of blood may be supplied to either or both of a first branch or second branch. The first branch may lead to an external blood oxygenator. The oxygenator may oxygenate the blood, and the blood may be returned to the circulatory system of the mammalian subject. The second branch may bypass the oxygenator and may connect to the circulatory system of the mammalian subject. In this regard, while the blood is supplied to the second branch, the oxygenator may be disconnected and blood may be prevented from entering the first branch. 1. A portable lung assist system , comprising:a blood pump having a pump outlet and a pump inlet configured for communication with a circulatory system of a patient at an inlet location; andan external and portable blood oxygenator having a blood inlet releasably connectable to the pump outlet and a blood outlet releasably connectable to the circulatory system of the patient at a return location.2. The system of claim 1 , further including a bypass conduit connectable to the blood pump and configured to be in fluid communication with the patient's circulatory system when connected to the blood pump claim 1 , wherein the blood inlet and the blood outlet are releasably connectable when the blood pump and the bypass conduit are connected to the circulatory system.3. The system of claim 2 , further comprising a first return fitting and a second return fitting adapted for connection to the circulatory system at the return location and adapted for respective connection to the blood outlet and the bypass conduit.4. The system of claim 2 , wherein the inlet location and the return location are located within a same anatomical feature of the circulatory system ...

METHOD AND APPARATUS FOR PERITONEAL OXYGENATION

Embodiments of the invention provide apparatus, systems and method for introducing fluids into a body cavity for treatment. One embodiment provides an apparatus for treating a patient including an access device for insertion into the peritoneal cavity of the patient including an infusion member in a lumen of the access device. An oxygenated solution may be infused and removed into and out of the cavity via the infusion member. 1. An apparatus configured to treat a patient , the apparatus comprising:an access device configured to be inserted a controlled depth into a peritoneal cavity of the patient, the device including a lumen and a tissue penetrating distal end;an infusion member positioned within a lumen of the access device and advanceable into the peritoneal cavity of the patient, the infusion member including a first lumen and a second lumen for the infusion and removal of an oxygenated solution into and out of the peritoneal cavity;an oxygen sensor configured to monitor an oxygen partial pressure of the patient or an oxygen saturation of the solution; andan electronic controller configured to control the infusion and removal of the solution into and out of the peritoneal cavity through the infusion member based on the monitored oxygen partial pressure or the oxygen saturation.2. The apparatus of claim 1 , wherein the first or second lumen is sized to deliver sufficient oxygenated solution to the cavity to at least partially meet the oxygen demands of the patient.3. The apparatus of claim 1 , wherein the oxygen sensor is configured to monitor the oxygen partial pressure of the patient.4. The apparatus of claim 1 , wherein the oxygen sensor is configured to monitor the oxygen saturation of the solution.52. The apparatus of claim 1 , wherein the apparatus includes a CO sensor.6. The apparatus of claim 1 , wherein the access device includes a substantially atraumatic tip.7. The apparatus of claim 1 , wherein the access device includes a sensor configured to ...

MEDICAL RESERVOIR LEVEL SENSOR

Devices can be used to detect a level of a fluid in a medical fluid reservoir. Methods for controlling the flow rate of a medical pump, and/or the occlusion amount of a medical fluid tube, that are based on the detected level of fluid in the medical reservoir can be used in a clinical setting. 1. A medical fluid reservoir comprising:a reservoir shell defining an interior space that is configured to receive a medical fluid; anda level sensor that is coupled to the reservoir shell, the level sensor comprising a plurality of electrode pairs that are electrically uninsulated in relation to the interior space, wherein individual electrode pairs of the plurality of electrode pairs are disposed at respectively differing elevations in relation to the reservoir shell.2. The medical fluid reservoir of claim 1 , wherein the level sensor is adhesively laminated to an interior wall of the reservoir shell.3. The medical fluid reservoir of claim 1 , wherein the level sensor further comprises a plurality of electrically insulated electrical conductors claim 1 , wherein individual ones of the plurality of insulated electrical conductors are connected to each electrode of the plurality of electrode pairs.4. The medical fluid reservoir of claim 3 , wherein the plurality of insulated electrical conductors are disposed within a wall of the reservoir shell.5. The medical fluid reservoir of claim 1 , wherein the plurality of electrode pairs comprises at least three electrode pairs.6. A medical fluid system comprising:a reservoir shell defining an interior space that is configured to receive a medical fluid;a level sensor that is coupled to the reservoir shell, the level sensor comprising a plurality of electrode pairs that are electrically uninsulated in relation to the interior space, wherein individual electrode pairs of the plurality of electrode pairs are disposed at respectively differing elevations in relation to the reservoir shell; anda pump system that is configured to pump the ...

SYSTEMS AND METHODS FOR EXTRACORPOREAL SUPPORT

The example systems, apparatus and methods use a local perfusion extracorporeal circuit (LPEC) for perfusing a local target region of a body, with a systemic perfusion extracorporeal circuit (SPEC) coupled to the core region of the vasculature using a peripheral placed loop to the body, and a control procedure to cause the local target region of the body to be at a specified pattern of temperature values that are different than the temperature of the core of the body. 1. A method for establishing and controlling two different temperature zones of at least portions of a body for at least portions of a treatment procedure for a patient that suffered a local or global ischemic insult or circulation damage , the method comprising: a SPEC input flow port and a SPEC output flow port to be in contact with blood flowing within the vasculature;', 'a SPEC pump; and', 'a SPEC heat exchanger;, 'coupling a systemic perfusion extracorporeal circuit (SPEC) to the body using a peripheral placed loop, the SPEC comprising a LPEC input flow port and a LPEC output flow port to be in contact with blood flowing within the vasculature, wherein the LPEC input flow port is disposed to perfuse the local target region of the body;', 'a LPEC pump; and', 'a LPEC heat exchanger;, 'coupling a local perfusion extracorporeal circuit (LPEC) to blood flowing within the vasculature to a local target region of the body, the LPEC comprisingpositioning at least one SPEC sensor to measure the average core body temperature and/or average system temperature of the body perfused by the SPEC;positioning at least one LPEC sensor to measure the temperature of the local target region perfused by the LPEC;performing operational steps of at least a minimum operating sequence; causes the SPEC to control the temperature of the blood injected by the SPEC to adjust the temperature measurement reported by the SPEC temperature sensors to stay within a target core body temperature range; and', 'causes the LPEC to control ...

APPARATUS AND METHOD FOR CONTROLLING FLUID FLOW

Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.

System for Controlling Blood Flow Rate in an Extracorporeal Blood Oxygenation Circuit

A control system in a blood line () of a cardiopulmonary bypass perfusion system () comprises a flow sensor () to determine a flow value indicative of the flow rate, a controller configured to process the flow value, and an adjustable restriction () responsive to the controller, to reduce the flow rate in the venous blood line () to maintain a flow rate to the venous blood reservoir that does not exceed a restriction threshold. As the adjustable restriction () is responsive to the flow sensor (), this provides a closed loop control mechanism that avoids restricting the blood line () of the perfusion system () more than intended. 1. A control system to restrict the flow rate of blood in a blood line in which blood is permitted to flow from an inlet towards an outlet , wherein the control system comprises:a first flow sensor configured to determine a first flow value indicative of the flow rate in the blood line,a controller configured to process the first flow value, andan adjustable restriction responsive to the controller, wherein the adjustable restriction is configured to reduce the flow rate in the blood line to maintain a flow rate that does not exceed a restriction threshold.2. The control system in accordance with claim 1 , further configured to determine if the first flow value exceeds the restriction threshold by a pre-determined margin claim 1 , and configured to effect an adjustment of the adjustable restriction to maintain the flow rate below the restriction threshold.3. The control system according to claim 1 , wherein the adjustable restriction comprises a gradually actuatable occlusive device.4. The control system according to claim 1 , wherein the blood line comprises a venous line for draining blood into a reservoir claim 1 , and wherein the first flow sensor is configured to determine the first flow value indicative of the venous flow rate and wherein the adjustable restriction is configured to maintain the venous flow rate in the venous line.5. ...

Ventilation System

An oxygenation system for a ventilation system comprises an inlet for receiving oxygenation gas at an oxygenation gas flow rate into an oxygenator, and an exhaust gas remover to remove exhaust gas at an exhaust gas flow rate from the oxygenator, and one or more flow controllers for controlling the exhaust gas flow rate relative to the oxygenation gas flow rate. This allows the amount of total gas entering the oxygenator and the amount of total gas removed from the oxygenator to be controlled with greater accuracy. 1. An oxygenation system for a ventilation system , the oxygenation system comprisingan inlet for receiving oxygenation gas at an oxygenation gas flow rate into an oxygenator, andan exhaust gas remover to remove exhaust gas at an exhaust gas flow rate from the oxygenator,wherein the oxygenation system further comprises at least one flow controller for controlling the exhaust gas flow rate relative to the oxygenation gas flow rate.2. The oxygenation system according to claim 1 , wherein the at least one flow controller is configured to maintain a predetermined flow ratio of the exhaust gas flow rate to the oxygenation gas flow rate.3. The oxygenation system according to claim 1 , wherein the the at least one controller is configured to maintain the exhaust gas flow rate at a predetermined offset level above or below the oxygenation gas flow rate.4. The oxygenation system according to claim 1 , wherein the the at least one flow controller is configured for maintaining the exhaust gas flow rate higher than the oxygenation gas flow rate.5. The oxygenation system according to claim 1 , wherein the exhaust gas remover is vacuum-assisted to generate a vacuum-induced flow claim 1 , to assist the removal of exhaust gas from the oxygenator.6. The oxygenation system according to claim 1 , wherein the flow controller is configurable to maintain the flow rate of the exhaust gas removed from the oxygenator above a pre-determined threshold.7. The oxygenation system ...

Method of making an enhanced flexibility neurovascular catheter

A method of making a high flexibility distal zone on a neurovascular catheter is provided. The method includes the steps of dip coating a removable mandrel to form a tubular inner layer on the mandrel, coating the tubular inner layer with a tie layer, applying a helical coil to the outside of the tie layer, positioning a plurality of tubular segments, heating the tubular segments to form the high flexibility distal zone on the neurovascular catheter; and removing the mandrel. 1. (canceled)2. A method of making a flexible distal zone on a neurovascular catheter , the method comprising the steps of:dip coating a removable mandrel to form a tubular inner layer on the mandrel;coating the tubular inner layer with a tie layer;applying a helical coil to an outside of the tie layer;applying a tubular braid to the outside of the tie layer, the tubular braid extending proximally from the helical coil to form a tubular body; a proximal section comprising a proximal end and a distal end, wherein each of the durometers of the plurality of tubular segments positioned along the proximal section is equal to or greater than 65 D,', 'a distal section comprising a proximal end and a distal end, wherein each of the durometers of the plurality of tubular segments positioned along the distal section is equal to or less than 35 D, and', 'a transition section extending between the distal end of the proximal section and the proximal end of the distal section, wherein the transition section comprises at least two tubular segments of the plurality of tubular segments, wherein each of the durometers of the at least two tubular segments is less than 65 D and greater than 35 D, and wherein the transition section is shorter in length than each of the proximal section and the distal section;, 'positioning a plurality of tubular segments over the tubular body, the plurality of tubular segments each comprising a durometer, the durometers of the plurality of tubular segments decreasing in value in a ...

CARDIAC DRAINAGE CANNULA AND RELATED METHODS AND SYSTEMS

The disclosure provides a method of placing a cardiac drainage cannula into a patient's heart. In some embodiments, the method comprises the steps of (a) inserting the cannula percutaneously into an internal jugular vein, (b) advancing the cannula through the internal jugular vein and into the right atrium of the heart, and (c) advancing the cannula through the atrial septum into the left atrium of the heart. Further aspects of the disclosure provide a method of draining blood from the left atrium or left ventricle of a patient's heart using a cardiac drainage cannula. The disclosure also provides a cardiac drainage cannula and a mechanical circulatory support system. 1. A method of placing a cannula within a left atrium of a heart in a living body , comprising:(a) inserting the cannula percutaneously into an internal jugular vein of the body,(b) advancing the cannula through the internal jugular vein and into the right atrium of the heart, and(c) advancing the cannula through the atrial septum into the left atrium of the heart.2. The method of claim 1 , wherein the step (c) further comprises:advancing the cannula from the left atrium through the mitral valve of the heart into the left ventricle of the heart.3. The method of claim 1 , further comprising:forming a percutaneous puncture by means of a needle, including puncturing the skin with the needle and advancing the needle through the skin and towards the internal jugular vein, and puncturing a wall of the internal jugular vein.4. The method of claim 1 , further comprising:puncturing the atrial septum using a sharp instrument to form a transseptal puncture, wherein step (c) includes advancing the cannula through the transseptal puncture of the atrial septum.5. The method of claim 1 , further comprising:fixating the cannula to a skin portion adjacent to a percutaneous insertion site of the cannula.6. The method of claim 5 , wherein the fixating the cannula to the skin portion adjacent to the percutaneous insertion ...

Method and apparatus for controlled reoxygenation

Blood filter

A blood filter such as may be used in a cordiopulmonary bypass system includes a housing having upper and lower chambers with a cylindrical filter element disposed in the lower chamber. The inlet to the housing is in the upper chamber, which is upstream of the lower chamber, and the outlet is through the lower chamber and communicates with the interior of the filter element. Thus, blood enters the upper chamber and flows to the lower chamber where it passes through the filter element from the outer side to the interior to remove microemboli such as gas bubbles, fat emboli and agglomerates, the filtered blood exiting through the outlet. In order to remove a substantial amount of the gas in the blood, and particularly gross bubbles, upstream of the filter element, the upper chamber is cylindrical and the inlet directs the blood tangentially to flow around the periphery of the chamber. An annular baffle extending around a major portion of the chamber maintains the peripheral flow which produces a centrifugal action causing the blood to flow at the wall of the chamber and the gas to separate and move to the central portion where it is vented through a hydrophobic membrane covering the central portion of the top wall of the chamber. Blood from the periphery of the upper chamber flows down to the lower chamber through a sponge ring which removes additional gas bubbles by causing the latter to coalesce into larger bubbles which move radially inwardly of the ring and rise to the upper chamber where they also are vented through the membrane. Any gas bubbles which remain in the blood and which are larger than the acceptable size are blocked by the filter element. The bubbles at the filter element eventually coalesce into larger bubbles which break away from the filter element and rise to the upper chamber where they are vented through the membrane.

System and method for high pressure delivery of gas-supersaturated fluids

A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a fluid to be gas-supersaturated and a drive assembly for delivering the fluid to a delivery site. The housing assembly comprises a cylinder and a piston which may be advanced along the inner surface of the cylinder to pressurize and to deliver the fluid. To generate a gas-supersaturated fluid, the housing assembly is removed from the system housing, filled with a fluid, and gas is introduced at or slightly above the desired gas partial pressure into the cylinder. To deliver the gas-supersaturate fluid, the fluid assembly is returned to the system housing and the drive assembly advances the piston to increase the hydrostatic pressure to the desired delivery pressure and, after opening a valve, to deliver the gas-supersaturated fluid at the desired high delivery pressure to a delivery site.

Cardiotomy reservoir

A cardiotomy reservoir for separating air from blood including a housing having top, bottom and side walls and defining upper and lower cylindrical chambers. A defoaming element comprising an annulus of sponge material is disposed in the upper end of said lower chamber and extends around the periphery of the housing. The upper chamber includes a channel for directing blood to the sponge annulus whereby the blood flows through the latter to the lower chamber, the sponge annulus including an antifoaming agent for causing air bubbles in the blood to coalesce and form larger air bubbles as the blood flows through the sponge annulus. A passage is disposed between the sponge annulus and the upper chamber whereby large air bubbles exit the sponge annulus and move through the passage to the upper chamber where air but not blood is vented automatically to the atmosphere through a hydrophobic membrane.

System and method for high pressure delivery of gas-supersaturated fluids

A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a fluid to be gas-supersaturated and a drive assembly for delivering the fluid to a delivery site. The housing assembly comprises a cylinder and a piston which may be advanced along the inner surface of the cylinder to pressurize and to deliver the fluid. To generate a gas-supersaturated fluid, the housing assembly is removed from the system housing, filled with a fluid, and gas is introduced at or slightly above the desired gas partial pressure into the cylinder. To deliver the gas-supersaturated fluid, the fluid assembly is returned to the system housing and the drive assembly advances the piston to increase the hydrostatic pressure to the desired delivery pressure and, after opening a valve, to deliver the gas-supersaturated fluid at the desired high delivery pressure to a delivery site.

AN IMPROVED BLOOD OXYGENER

System for enriching a bodily fluid with a gas

A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.

System for enriching a bodily fluid with a gas

A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.

Disposable cartridge for producing gas-enriched fluids

A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

Blood/gas separator and flow system

A blood reservoir is formed with a hard outer shell housing defining at least one blood compartment. A flexible bag is mounted in the outer shell and is connected to the reservoir inlet port to allow blood to directly enter the flexible bag. The bag includes two oppositely positioned ends, one of which includes a mircoporous screen and is situated to lie partially below a minimum level attained by blood in the reservoir. The second bag end is substantially open, and includes a porous element partially coated with an antifoaming agent. The coated portion of the element is positioned above a maximum level attained by the blood in the hard shell. The potential of excessive mixing between the blood and air is reduced by controlling the expansion of the bag during blood flow.

带有rfid特征激活的灌注系统

本公开涉及在分流过程期间容易设置、使用和监视的灌注系统(10)。在一些实施方式中，本公开涉及一种灌注系统(10)，其中，与该一灌注系统(10)起使用的一次性组件(14)中的至少一些被配置为能够将设置和/或操作参数发送至灌注系统以为了将灌注系统内的进一步功能(29)解锁。

Neurovascular catheter with enhanced flexibility

提供了一种例如用于远侧神经血管进入或吸取的导管。该导管包括长形的柔性本体，其具有近端、远端和限定中央内腔的侧壁。侧壁的远侧区包括：管状的内侧衬垫；通过内侧衬垫与内腔分离开的连结层；包围连结层的螺旋线圈，该线圈的相邻绕圈在远侧方向上逐渐越来越逐渐间隔开。外侧壳套包围螺旋线圈。外侧壳套由绕线圈同轴地端对端安置的多个管状部段形成。取决于导管长度的导管的挠曲载荷曲线构造成在维持高支持性的同时提供增强的远侧柔性。

Oxygenator

System for enriching a bodily fluid with a gas having a removable gas-enrichment device with an information recording element

This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid via an extracorporeal circuit. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. The gas-enrichment device has an information recording element disposed thereon. During operation, the gas-enrichment device is placed in an enclosure within the control module. An electronic controller manages the various aspects of the system such as the production of gas-enriched fluid, flow rates, bubble detection, and automatic operation and shut down. The controller is capable of setting a fluid flow rate in the circuit according to a programming based on the information encoded in the information recording element.