MEASURING APPARATUS AND ARTIFICIAL DIURESIS DEVICE

A measuring apparatus and artificial diuresis device wearable by a patient (H) and comprising a reusable machine (2) and a disposable unit (3).

Extracorporeal circulation cassette

This extracorporeal circulation cassette is provided with: a blood circuit (10) comprising a flexible tube and having a blood tube access portion set in a predetermined position in a device; a dialysate circuit (12) comprising a flexible tube and having a dialysate tube access portion set in a predetermined position in the device; a first panel (4) and a second panel (6) that are rigid and that integrate the blood circuit (10) and the dialysate circuit (12) while sandwiching the blood circuit (10) and the dialysate circuit (12) from both sides; and a window portion formed in a part of at least one of the first panel (4) and the second panel (6), disposed in a predetermined position in the device. The blood tube access portion and the dialysate tube access portion are positioned in the window portion.

ARTIFICIAL DIURESIS DEVICE

Biological component collection cassette, kit, or system, and method of manufacture

A blood component collection cassette has a flow path in the interior thereof through which blood flows, and a cassette main body composed of a resin that possesses flexibility. The cassette main body includes a first constituent part in which a plurality of concavities and convexities are formed. Furthermore, a resin sheet includes a second constituent part, which is provided on one portion of an outer surface of the flow path wall portion that constitutes the flow path, and in which the plurality of concavities and convexities do not exist.

Patient and treatment records

The exemplary systems and methods may generate treatment records for extracorporeal blood treatments. The treatment records may include a plurality of values of various parameters. The various parameters may include a compulsory set of parameters that are preset, a dependent set of parameters that a dependent on one or more of a selected treatment and a system configuration, and a discretionary set of parameters that are selected by a user.

Disposable cartridge and pump track mechanism

Disclosed are example embodiments of a dialysis machine having a frame, a cartridge cassette, one or more alignment-locking features, and an actuation mechanism. The frame is fixedly coupled to the dialysis machine, and the cassette is slidably coupled to the frame. The cassette can have one or more track structures, with each of the one or more track structures having a rotor and one or more rollers. The one or more alignment-locking features extend from the frame and are configured to be inserted into one or more alignment features of a disposable cartridge that functions to secure or release the disposable cartridge. The actuation mechanism is made to slide the cassette with respect to the one or more track structures.

Methods And Systems For High-Throughput Blood Component Collection

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

SYSTEMS AND METHODS FOR PRIMING A CONTINUOUS-FLOW CENTRIFUGE CHAMBER

Method And Systems For High-Throughput Blood Component Collection

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

MODULAR IRRADIATION DEVICE AND IRRADIATION METHOD

SYSTEMS AND METHODS FOR ENSURING PROPER TUBING INSTALLATION FOR FLUID PROCESSING SYSTEMS

Methods and systems for high-throughput blood component collection

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Blood purification device

A blood purification device includes a device body and a cassette. The cassette includes: a casing that accommodates a removal water receptacle; and pump tube. The device body includes fingers, a driving unit, and a housing. The cassette can be attached to and removed from the housing of the device body so that the pump tubes are positioned between the plurality of fingers and the outer surfaces of the casing.

Methods and systems for high-throughput blood component collection

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Blood component collection cassette and manufacturing method of the same

A blood component collection cassette that can trap a foreign object such as a blood-coagulated clot from blood components to be returned to a blood donor and a manufacturing method of the blood component collection cassette are provided. A sheet-shaped filter member (60) is arranged on a flow path (42) in a cassette main body (40) of a blood component collection cassette (28). A first tube (66) and a second tube (68) are arranged in the cassette main body (40). An inner space (51) of a filter housing unit (54a) is separated by the filter member (60) into a first space (51a) on the side of the first tube (66) and a second space (51b) on the side of the second tube (68).

METHOD FOR DISCONNECTION

The present invention relates to a method for disconnecting two fluid-conducting line sections of a medical device which are detachably interconnected, wherein a first line section of the two line sections has at least partially an elastic property. The method comprises the steps of enclosing a fluid volume in the two line sections, generating a reduced pressure in the two line sections, as a result of which elastic deformation from a starting position into a tensioned position takes place in and/or on the first line section, wherein a fluid volume contained in the first line section is lower in the tensioned position than a fluid volume contained in the starting position, and detaching the connection of the line sections, wherein the fluid volume contained in the first line section in the tensioned position increases. Furthermore, the invention relates to a medical device which is configured to carry out a method of this kind.

Extracorporeal blood treatment system and method including modifiable settings

Graphical user interfaces for use with extracorporeal blood treatment systems may include a plurality of mini settings cards corresponding to a plurality of settings cards. The mini settings cards may display one or more user-interactable settings, and may be selected to display the corresponding settings card. Further, each settings card may be accessed in other ways to selection of mini settings card such as, for example, by selection of a process feature graphical element corresponding the settings card.

Integrated disposable set for an apheresis system

An integrated pre-connected apheresis disposable set for separating plasma from blood in a separation vessel and further separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.

System for Blood Separation with Side-Tapped Separation Chamber

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.

Dialysis Systems and Methods

This invention relates to dialysis systems and methods. In some implementations, a method includes applying vacuum pressure to a device of a dialysis system, and then determining, based on a detected fluid level or measured pressure, whether the device is functioning properly.

Medical functional device, treatment apparatus and method

A medical functional device includes at least one first fluid system for receiving at least one medical fluid, at least one first conveying device for conveying the medical fluid, at least one second fluid system for receiving at least one operating fluid, and at least one second conveying device for operating the at least first conveying device, in which the first conveying device is arranged such as to be actuated by means of the operating fluid. A treatment apparatus and a method are also described.

Method as well as apparatuses for removing gas accumulations from a component of an extracorporeal blood circuit

The present invention relates to a method for removing gas accumulations from a component of an extracorporeal blood circuit, a control device for executing a method according to the present invention, a medical treatment apparatus which comprises at least one control device and/or stands in signal transmission or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

Blood treatment systems and methods

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

System and Method For Collecting And Treating Plasma Protein Fractions

Method and apparatus for separating plasma from blood in a separation vessel, separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma, and adding photosensitizer to the desired plasma proteins for viral inactivation treatment of such proteins.

Membrane separation devices, systems and methods employing same and data management systems and methods

A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

Magnetic sensors and related systems and methods

This invention relates generally to magnetic sensors and related systems and methods. In some aspects of the invention, a magnetic sensor assembly includes a housing configured to releasably hold a medical fluid tube and a sensor secured to the housing, the sensor configured to detect a change in a strength of a magnetic field when a medical fluid passes through the medical fluid tube.

Blood perfusion system

An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.

Fluid Cassette With Alignment Latching Having An Improved Tilt-Tolerance As Well As A Blood Treatment Apparatus

A fluid cassette, for example, a blood treatment cassette having a cassette body embodied as a hard part and, optionally, a film which is connected to the hard part and at least partially covers the hard part, wherein the hard part comprises at least one first alignment device, and a second alignment device which are optionally arranged at first and second opposite sides of the fluid cassette or are attached thereon. The disclosure relates in addition to a blood treatment apparatus.

Pressure Measurement Devices, Methods, And Systems

A pressure measurement system for use in blood circuits comprised of a pressure sensing pod and a force measurement device. The pressure sensing pod can include a flexible, moveable, fluid-impermeable diaphragm and can be formed via either a one-shot or a two-shot molding process. A mechanical engagement member of the force measurement device engages with a mechanical engagement feature of the diaphragm, and the engagement member is operative to move in concert with movement of the engagement feature of the diaphragm based on pressure variations with the pressure sensing pod. The force measurement device generates and outputs to a processor a signal based on detected force associated with movement of the engagement member.

Dialysis system including automatic priming

A hemodialysis system comprising: a source of priming fluid; an extracorporeal circuit including an arterial line, a venous line, and a drip chamber; a level sensor operable with the drip chamber; a reversible blood pump operable with the extracorporeal circuit; a connection between the arterial and the venous line; and a priming sequence in which priming fluid from the source is pumped in a reverse pump direction through the extracorporeal circuit and reversibly in a normal pump direction through the extracorporeal circuit, wherein an output from the level sensor is used to determine when to stop pumping in at least one of the directions.

Dialysis systems including therapy prescription entries

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

Hemodialysis system including a disposable cassette

A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.

Portable hemodialysis assembly with ammonia sensor

A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. Preferably, the filter has a vapor membrane for releasing gases including ammonia, but not liquids such as the dialysate. The reused dialysis machine possesses a reservoir for dialysate, an ammonia sensor adjacent to the vapor membrane, a level sensor, a blood leak sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment.

Portable hemodialysis machine and disposable cartridge with blood leak sensor

A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate. The reused dialysis machine possesses a reservoir for dialysate, various sensors including a blood leak sensor assembly, and a processor connected to the various sensors for controlling and monitoring hemodialysis treatment. The blood leak sensor assembly includes a light source for emitting light through the dialysate flow path and a light sensor for receiving light having passed through the dialysate flow path. The processor is connected to the light source for determining whether blood has leaked from the blood flow path into the dialysate flow path. Preferably, the light source emits light having two peak wavelengths.

Platelet collection method and platelet collection system

A platelet collection method includes a step of accommodating whole blood in a first chamber (44) and performing centrifugal separation, a step of transferring a buffy coat resulting from the centrifugal separation to a second chamber (50), and a step of performing centrifugal separation on the buffy coat. Subsequently, a step of transferring a platelet-containing component resulting from the centrifugal separation to a third chamber (52) and a step of performing centrifugal separation on the platelet-containing component are executed. Also performed in the collection method are a step of introducing a platelet additive solution into the third chamber (52) and replacing plasma resulting from the centrifugal separation and a step of collecting platelets remaining in the third chamber (52) along with the platelet additive solution.

Medical Device With An Additively Applied Converter

This disclosure relates to a medical device including a hard part and a converter. The hard part has fluid paths for conducting a medical fluid through the hard part. The converter is arranged to measure a characteristic of the medical fluid while the medical fluid is present in one of the fluid paths. At least a section of the converter is applied or superimposed to the hard part by at least one additive application method.

Collecting Components of a Fluid

Embodiments are described for separating/collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.

Method and apparatus to verify correct replacement fluid in a therapeutic exchange procedure

A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.

Enclosure for a portable hemodialysis system

An enclosure for containing a portable hemodialysis unit includes a housing suitable to support components for performing hemodialysis including a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer. The housing may have a front panel at which blood circuit connections and dialysate fluidic connections are located, e.g., blood line connections for patient blood access, connections for a reagent supply, dialyzer connections for both blood flow and dialysate, etc. The enclosure may also include a pair of vertical, side-by-side doors hingedly mounted to the housing. With the doors in the closed position, access to the patient access and dialysate fluidic connections may be blocked, and the doors may allow for the retention of heat in the housing suitable for disinfection during a disinfection cycle.

Non-Invasive Identification Of Solutions

A fluid identification assembly is provided to determine the presence or absence of multiple components within a fluid in a conduit. The assembly includes a light source and a light detector positioned to receive a portion of light from the light source reflected by the conduit and fluid. A dual-band bandpass filter may be associated with the light detector to allow multiple wavelengths of light to be monitored, thereby monitoring the composition of the fluid based on the amount of light of each wavelength absorbed by the fluid. Rather than a dual-band bandpass filter, a second light detector may be provided, along with a beam splitter to separate light from a single source for receipt of light of different wavelengths by the light detectors. The dual-band bandpass filter may also be replaced by a second light source and detector pair for analyzing fluid using multiple wavelengths of light.

Medical Treatment Device And Method For Monitoring A Medical Treatment Device

The invention relates to a medical treatment device comprising a fluid system, which has a monitoring apparatus 27 for monitoring the treatment device, wherein the monitoring apparatus 27 is configured such that monitoring is based on the evaluation of the pressure in the fluid system of the medical treatment device. The invention further relates to a method for monitoring a medical treatment device, in which monitoring is based on the evaluation of the pressure in the fluid system. The treatment device is characterised by a compliance-determining apparatus 28 for determining the compliance in the fluid system, part of the fluid system or parts of the fluid system, wherein the compliance-determining apparatus 28 cooperates with the monitoring apparatus 27 in such a manner that the pressure-based monitoring takes place depending on the compliance of the fluid system.

Fluid processing apparatus

A machine is provided with a slot to releasably receive and retain a cartridge in which dialysis is effected. The machine is configured for supplying to the cartridge, at a controlled temperature and rate, sterile water for use in haemodialysis and is operable to maintain, in a sterile condition, residual water contained therein after completion of a haemodialysis treatment.

Blood purification device

A blood purification device includes a device body and a cassette. The cassette includes: a casing that accommodates a removal water receptacle; and pump tube. The device body includes fingers, a driving unit, and a housing. The cassette can be attached to and removed from the housing of the device body so that the pump tubes are positioned between the plurality of fingers and the outer surfaces of the casing.

Systems Enabling Alternative Approaches To Therapeutic Red Blood Cell Exchange And/Or Therapeutic Plasma Exchange

Systems and methods are provided for therapeutic red blood cell exchange and/or therapeutic plasma exchange. A blood separation device includes a centrifugal separator, a spinning membrane separator drive unit, a pump system, and a controller. Blood is conveyed through a fluid flow circuit into either the centrifugal separator or the spinning membrane separator, which separates out the target blood component (red blood cells, in the case of therapeutic red blood cell exchange, or plasma, in the case of therapeutic plasma exchange). The target blood component is retained in the circuit as a waste product, while a replacement fluid is added to the remaining blood component(s), which is then conveyed to a recipient. In addition to allowing for execution of an exchange procedure using either a centrifugal separator or a spinning membrane separator drive unit, the blood separation device also allows for the use of differently sized spinning membrane separators.

Medical fluid sensors and related systems and methods

This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a nuclear magnetic resonance device includes a support frame, a first magnet connected to the support frame, a second magnet connected to the support frame in a manner such that the second magnet is disposed within the magnetic field of the first magnet and a magnetic attraction exists between the first magnet and the second magnet, and a spacer disposed between the first magnet and the second magnet. The spacer is configured to maintain a space between the first magnet and the second magnet.

Blood bag system and cassette

A blood bag system includes a BC pooling bag for centrifugation of a buffy coat, a filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, a first tube connecting the BC pooling bag and an inlet of the filter, a second tube connecting the platelet preserving bag and an outlet of the filter, and a cassette to be fixed in the centrifugation and separation apparatus. The first tube and the second tube are disposed within the cassette. The cassette includes a first clamp section for closing and opening the first tube, and a second clamp section for closing and opening the second tube.

Collecting Components of a Fluid

Embodiments are described for separating/collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.

Localized Therapy Delivery and Local Organ Protection

A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.

Systems for Utilizing Crossflow Filtration for Cell Enrichment

A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Flexible tubing occlusion assembly

An occlusion assembly for compressing a pair of collapsible tubes comprises a frame comprising a tubing guide configured for positioning the collapsible tube. The occlusion assembly also comprises a tubing occluder mounted to the frame with an occluding member constructed and positioned to controllably occlude or release occlusion of the collapsible tube. A door mounted to the frame is positioned to cover at least a portion of the collapsible tube and tubing occluder when closed and provide user access when open. The assembly includes a retainer mechanism engaged by the door when the door is closed to permit operation of the tubing occluder when the door is closed and retain the tubing occluder in a non-occluding configuration when the door is opened.

Blood treatment systems and methods

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Method For Operating A Blood Treatment Apparatus, Control Unit And Treatment Apparatus For Executing The Method

A method for operating a blood treatment apparatus including an extracorporeal blood circuit having a blood filter with a blood chamber and a dialysate chamber, between which a membrane is arranged. The method encompasses operating a blood pump from a first time point, at which an ultrafiltration pump is stopped, at least until a second time point, at which at least one of the following conditions is met for the first time after the first time point: a time interval after has elapsed, the blood pump has conveyed a volume after, a measurement of a fluid in the extracorporeal blood circuit exceeds or falls below a threshold.

Automated methods and systems for washing platelet concentrates

Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.

Automated Extracorporeal Blood Treatment Apparatus

The present invention provides an extracorporeal dialysis apparatus which allows the automation of some operations in order to make possible a safe home treatment or to facilitate the treatment process for example the priming and/or the blood return process. Thus, the object is to automatically perform a series of processes from hemodialysis preparation to treatment completion safely, reliably and speedily, and to significantly reduce the labor and supply costs.

Dialysis system and methods

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

Portable hemodialysis machine and disposable cartridge

A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialyzer, and a dialysate flow path and a blood flow path which flow in opposing directions through the dialyzer. The disposable cartridge includes pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. In addition, the disposable cartridge possesses pump actuators (but not pump motors) for pumping dialysate and blood through their respective flow paths. Preferably, the disposable cartridge includes a filter for removing waste products from dialysate.

Patient and treatment records

The exemplary systems and methods may generate treatment records for extracorporeal blood treatments. The treatment records may include a plurality of values of various parameters. The various parameters may include a compulsory set of parameters that are preset, a dependent set of parameters that a dependent on one or more of a selected treatment and a system configuration, and a discretionary set of parameters that are selected by a user.

Fluid pumping apparatus for use with a removable fluid pumping cartridge

The present invention involves, in some embodiments apparatus, such as dialysis apparatus, and methods for pumping fluid. Certain embodiments comprise a housing enclosing a pump drive assembly for actuating at least one pump on a removable fluid pumping cassette. The housing may comprise a door connected to the housing for enclosing an installed cassette in the housing upon closure of the door. The pump drive assembly may comprise a mating block configured for operative association with an installed cassette and may be configured to permit a sealing engagement with an installed cassette upon closure of the door. To facilitate sealing, certain embodiments of the door include a movable compression plate configured to exert a compressive force on an installed cassette against the mating block when the door is in a closed position.

Cardioplegia administration system and method

A cardioplegia administration system includes a tubing set, a positive displacement pump and a mixing system. The tubing set has a cardioplegia supply tube; a blood supply tube; and a cardioplegia administration tube connected to the cardioplegia and blood supply tubes. The positive displacement pump engages the cardioplegia administration tube to pump fluid therethrough. The mixing system includes pinch valves for alternately-continually pinching the cardioplegia and blood supply tubes to close and open the cardioplegia and blood supply tubes such that only one of the cardioplegia and blood supply tubes is open at a time, and a controller that controls the intervals during which the pinch valves are open to control the ratio of the cardioplegia medication and blood or blood substitute administered through the cardioplegia administration tube. The method of this invention includes the step, among others, of operating the pinch valves to close and open the cardioplegia and blood supply tubes so that only one of the cardioplegia and blood supply tubes is open at a time while controlling the intervals during which the pinch valves are open to control the ratio of the cardioplegia medication and blood or blood substitute administered through the cardioplegia administration tube.

Blood processing systems using a peristaltic pump module with valve and sensing station for operating a peristaltic pump tube cassette

A blood processing assembly includes a separation element for separating blood from a source into a first component and a second component. The assembly also includes a fluid path that conveys blood between the source and the separation element. The fluid path includes one or more in-line cassettes that serve in association with peristaltic pumps to centralize pumping and valving functions of the system. The cassettes also serve to segregate the flow paths of the blood components from each other.

Peristaltic pump tube cassette for blood processing systems

A cassette serves in association with one or more peristaltic pumps to centralize pumping, valving, and pressure sensing functions. The cassette includes a housing having first and second pump ports. A flexible tubing loop extends between the first and second pump ports outside the housing for engagement with an external peristaltic pump element. A liquid port on the housing attaches to a length of tubing that also extends outside the housing. Liquid passages within the housing that establish communication among the liquid port, the first pump port, and the second pump port. Valve stations formed within the housing are responsive to the application of external force for controlling liquid flow through the liquid passages. A sensing chamber is formed within the housing along at least one liquid passage. The sensing chamber transmits information regarding liquid pressure present within the one liquid passage to an external sensing element.

Peristaltic pump module having jaws for gripping a peristaltic pump tube cassett

A peristaltic pumping apparatus includes a peristaltic pump rotor and pump race. A pump tube cassette includes a body for supporting a flexible tubing loop in an erect, outwardly bowed position for placement within the pump race and for removal from the pump race. A surface juxtaposed the peristaltic pump rotor and race carries a gripping jaw assembly. The gripping jaw assembly opens to receive the pump tube cassette body as the body is moved toward the pump rotor to place the tubing loop within the pump race. The gripping jaw assembly closes to secure the pump tube holder body on the surface in an orientation in which the tubing loop lies within the pump race for engagement with the peristaltic pump rotor.

Self loading peristaltic pump tube cassette

A self-loading peristaltic pumping apparatus includes a pump race for receiving a tubing loop, a pump rotor carrying a roller, and a drive mechanism for rotating the rotor within the pump race. The apparatus also includes a roller locating mechanism that moves the pump roller between a retracted position, free of contact with the received tubing loop, and an extended position, at least partially within the pump race for operative contact with the received tubing loop. The apparatus includes at least one tubing guide element carried by the rotor. The guide element extends from the rotor at least partially into the pump race. The guide element serves during rotation of the rotor with the roller in its retracted position, for contacting the received tubing loop to orient the tubing loop within the pump race.

Extracorporeal blood processing methods and apparatus

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Extracorporeal blood processing methods and apparatus

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Apheresis system

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the utilization of high packing factors for the procedure.

Extracorporeal blood processing methods and apparatus

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Extracorporeal blood processing methods and apparatus

An extracorpeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Extracorporeal blood processing methods and apparatus

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Extracorporeal blood processing methods and apparatus

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Extracorporeal blood processing methods

A method for processing blood in an apheresis system is disclosed. The present invention includes selecting a packing factor for separated blood component types in the separation stage(s) of a blood processing vessel. A packing factor is a number that reflects the degree with which the blood component types are packed together in the separation stage(s) and is dependent at least upon the rotational speed and the flow rate into the blood processing vessel. The method further includes providing an apheresis system and operating it under conditions to separate the blood into a plurality of blood component types and achieve the selected packing factor.

Disposable for an apheresis system with a contoured support

An extracorporeal blood processing system is disclosed which includes a disposable for an apheresis system. The disposable can include a blood processing vessel and a contoured support. The blood processing vessel includes sidewalls to define the vessel and a blood inlet port and a blood component outlet port. The support is provided proximate to the blood component outlet port and exteriorly relative to the fluid-containing volume of the blood processing vessel. The support may be contoured to direct the desired blood component types(s) toward the blood component outlet port and is in an overlapping relation with the exterior surface of the blood processing vessel. The support and part of an adjacent channel wall collectively define a generally funnel-shaped collect well that collects blood components flowing thereby. The support may be pivotally or hingedly interconnected with the exterior of the blood processing vessel to facilitate loading of the blood processing vessel and/or to allow the support to move not a predetermined position upon pressurization of the blood processing vessel to perform the desired function during an apheresis procedure.

Integrated cassette for controlling fluid having an integral filter

An apparatus controls movement of fluids during an extracorporeal blood treatment session. A hollow cassette enclosure has a plurality of fluid input ports for receiving fluids into the enclosure and a plurality of fluid output ports for expelling fluids from the enclosure. Internal fluid passageways disposed within the hollow enclosure are provided for coupling together the fluid input ports, and the fluid output ports. At least one internal valve is disposed within the hollow enclosure for controlling movement of the fluid within the hollow enclosure. A filter is integrated into the cassette to filter the blood passing therethrough.

Blood treatment systems and methods

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Sistema de hemodiálisis.

Un casete de drenaje para una unidad de diálisis tiene un canal de fluido entre los puertos de conexión de venas y arterias, y una válvula puede abrir o cerrar de manera controlable la comunicación de fluido entre un puerto de salida de drenaje y el puerto de conexión de venas o el puerto de conexión de arterias; un ensamble de circuito de sangre y un casete de drenaje se pueden remover de la unidad de diálisis, por ejemplo, manualmente y sin el uso de herramientas; un ensamble de circuito de sangre puede incluir un miembro unitario sencillo que define porciones de un par de bombas de sangre, válvulas de control, canales para colocar de manera exacta los tubos flexibles para un oclusor y un soporte colector de aire y/u otras porciones del ensamble; un dispositivo de acoplamiento del ensamble de circuito de sangre puede ayudar a retener un ensamble de circuito de sangre en la unidad de diálisis y/o con remoción del ensamble; un accionador puede operar un elemento retención un elemento expulsor que interactúa con el ensamble.

Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to externally applied pressures

A fluid processing apparatus for use in conjunction with a prepackaged disposable fluid processing module of the type which includes an integral housing wherein fluid containers, tubing segments, and other components required in processing a fluid are contained, and wherein fluid communication between the containers, components and tubing segments is provided by a fluid circuit formed within the housing by a first relatively inflexible fluid-impervious sheet member and a second relatively flexible fluid-impermeable sheet member. The fluid circuit includes pump and valve elements which operate in response to pressures applied to the second sheet member. Upon installation of the system in the processing apparatus pneumatic actuator ports apply pressures to the second sheet member through access apertures in the housing to circulate fluid through the fluid circuit.

System for extrakorporeal blodbehandling

磁性传感器及相关系统和方法

本发明大致涉及一种磁性传感器以及相关的系统和方法。根据本发明的一些方面，磁性传感器组件包括：构造为可释放地保持医疗流体管的壳体、和固定到该壳体的传感器。该传感器构造为在医疗流体流经医疗流体管时检测磁场强度的变化。

Medical fluid cassettes and related systems

The invention relates to an apparatus for the treatment of a medical liquid comprising a liquid treatment machine and a cassette insertable therein substantially made of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.

Dialysis systems and related methods

A dialysis machine that includes a valve member having a deformable area configured to deform outwardly away when pressurized fluid is introduced into the valve member. The valve member is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the valve member, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough.

Fluid monitor system

Systems for monitoring fluids such as blood being treated extracorporeally are disclosed, including a monitor for monitoring the fluid flow through a tube system between a fluid inlet, fluid treatment means and a fluid outlet. The monitor disclosed includes a monitor housing which contains at least one pressure sensor, and a cassette which is adapted to be removably coupled to the monitor housing, the cassette including pressure transmission ducts for transmitting the pressure within the tube system to a pressure transmitting cavity adapted to be juxtaposed with the pressure sensor when the cassette is coupled to the monitor housing so that the pressure within the tube system can be directly measured by the pressure sensor when the cassette is coupled to the monitor housing. In one embodiment of the monitor the cassette includes a portion of the tube system, while in another embodiment a conventional tube system can be affixed to the cassette.

Apparatus for use with fluid flow transfer device

A fluid flow chamber cassette that can be mounted with either its front wall or rear wall against a supporting machine and has a flexible tube that extends from a sidewall and forms a loop that is symetrical about a loop axis that is transverse to the side wall so that the loop will be acted upon by a pump roller on the machine both when the front wall is against the machine and when the rear wall is against the machine. Also disclosed is automatically fixing the initial liquid levels and amounts of air in venous and arterial chambers of fluid flow transfer device apparatus by having the arterial chamber inlet enter the arterial chamber at a position higher than the arterial chamber outlet, having the venous chamber inlet enter the venous chamber at a position higher than the venous chamber outlet, and priming the apparatus by causing reverse flow, so that the liquid rises in the venous and arterial chambers to the level of the entrances of the inlets. Also disclosed is sensing pressure of fluid in a fluid flow chamber by placing an impermeable flexible diaphragm over a hole in a rigid wall of the fluid flow chamber, providing a second chamber on the other side of the diaphragm, and sensing the pressure in the second chamber.

Cardioplegia delivery system

A cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. A first pump combines the blood from the conduit with a second fluid and delivers the combined flow into the delivery line leading to the heat exchanger. A control panel is operatively connected for adjusting the ratio of blood and second fluid delivered by the first pump and for adjusting the total volumetric rate of flow from the first pump.

Fluid pumping systems, devices and methods

Reciprocating positive-displacement membrane pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid are disclosed. The speed of a pump stroke can be adjusted by altering a frequency of pressure pulses delivered to the pump membrane during a fill stroke or a delivery stroke of the pump. A pumping algorithm may divide a pump stroke into an initial pumping period and a end-of-stroke pumping period, with the pressure pulse duration being longer during the initial pumping period. This arrangement may allow for a minimum pump flow rate while also providing a pressure ripple that can be used to detect the end of a pump stroke.

Blood treatment systems and methods

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Hemodialysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures

A disposable prepackaged fluid processing module includes an integral housing wherein fluid containers, tubing segments, and other components required in processing a fluid are contained. Fluid communication between the containers, components and tubing segments is provided by a fluid circuit formed by a panel of the housing, and an overlying fluid-impermeable flexible sheet member. The fluid circuit includes pump and valve elements which operate in response to pressures applied to the sheet member. Upon installation of the system in a related actuator apparatus pneumatic actuator ports apply pressures to the pump and valve elements to circulate fluid through the fluid circuit.

Portable dialysis machine with improved reservoir heating system

The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan.

歧管膜片

本说明书公开了一种具有可拆卸的控制器单元和基部单元的便携式透析机。控制器单元包括：门，其具有内部面；具有面板的外壳，其中外壳和面板限定配置成接收门的内部面的凹陷区域；以及歧管接收器，其被固定地附接到面板。歧管包括膜片，其适于尽量减小透析机销之间的死空间并且提高响应性。基部单元具有：平面表面，其用于接收流体容器；秤，其与平面表面集成；以及加热器，其与平面表面热连通。所公开的便携式透析系统的实施方案具有改进的结构的和功能的特征，包括改进的模块性、易用性以及安全性特征。

Disposable cassette for cardioplegia delivery system

A disposable cassette for a cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. A first pump combines the blood from the conduit with a second fluid and delivers the combined flow into the delivery line leading to the heat exchanger. A control panel is operatively connected for adjusting the ratio of blood and second fluid delivered by the first pump and for adjusting the total volumetric rate of flow from the first pump.

Fluid flow cassette with pressure actuated pump and valve stations

A cassette for directing fluid flow, comprising a body and a valve chamber formed in the body, provides a centralized, programmable, and integrated platform to carry out diverse and coordinated pumping and valving functions, e.g., such as required for blood processing.

加えた圧力に応答して作動し得るポンプおよびバルブエレメントを有するあらかじめ実装された流体処理モジュ−ル

(57)【要約】本公報は電子出願前の出願データであるため要約のデータは記録されません。

Pump monitor for photoactivation patient treatment system

A preferred patient blood treatment system for the photoactivation of reagents in contact with a patient's blood employs an infusion pump for adding anti-coagulation reagent to the blood during extracorporeal operations. The infusion pump is preferably driven by a stepper motor and monitored by a periodic photo chopper employing a plurality of sensors. The spacing of the sensors and the spacing of the photo choppers work in concert to detect rotation of the stepper motor and to discriminate such from stutter or other characteristic nonrotational faults associated with stepper motors.

Apparatus for supporting a fluid flow cassette

Apparatus for supporting a fluid flow cassette having an opening for receiving a sensor, the apparatus including a sensor mounted on a support, means to lock the cassette into an insertion position with its opening aligned with but spaced from the sensor along an insertion axis, means to move the sensor relative to the opening to cause the sensor and opening to be brought together, and means to prevent the sensor and opening from coming close enough for the sensor to sealably engage the opening until after the cassette has been locked into the insertion position.

Blood pumping and processing system

A blood processing system is described in which blood pressure readings obtained before and after passage of blood aspirated from an operative site through a membrane separator is used by a programmed controller to determine the hematocrit level of the blood and to add saline solution to adjust the hematocrit level to a desired level. The blood processing system contains a distributor cap to distribute wash solution to the inside of a filter to wash out additional blood cellular material within the filter. A precollector may be used remotely from the site of the blood processing system and later joined with the system to withdraw blood contained in the precollector for processing by the blood processing system.

Constant pressure blood mixture delivery system and method

A system and method for blood mixture fluid delivery to a patient includes fluid delivery conduits connected to the patient for delivering blood mixture fluid, a pump for controlled pumping of blood mixture fluid through the conduits to the patient, and an automatic control mechanism operatively connected to the pump for controlling the pump so that the blood mixture fluid is continuously delivered to the patient at a defined constant pressure.

Peristaltic pump and valve assembly for fluid processing systems

A peristaltic pump includes a pump race for receiving a flexible tubing. A rotatable pump rotor carries at least one roller for contacting the tubing. A roller locating mechanism moves the pump roller between a retracted position free of contact with the tubing and an extended position making operative contact with the tubing. A controller operates the pump (i) in a pumping mode, during which the rotor is rotated with the roller located in its extended position, and (ii) in a valving mode, during which rotation of the rotor is terminated and the roller is selectively moved between its extended position to block fluid flow through the tubing and its retracted position to permit fluid flow through the tubing. The pump thus provides a peristaltic pump pumping function, as well as serving as a valve element.

Blood separation chamber with preformed blood flow passages and centralized connection to external tubing

A blood separation chamber comprises a base that includes formed walls that define a hub. A separation channel extends about the hub. A flow passage extends between the hub and the separation channel. The hub enables attachment of external tubing to convey blood to and from the separation channel through the hub.

Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing

Systems and related methods sense the presence of targeted cellular blood species during extracorporeal blood separation or processing. The systems and methods tailor the sensing parameters to the particular objectives of the blood processing procedure selected to be accomplished. Different cellular blood species are targeted for detection for different selected blood processing procedures. The systems and methods differentiate among different cellular blood species for detection, according to the blood processing procedure selected.

Technique for loading a pump header within a peristaltic pump of a dialysis machine

A pivotable cover secures a pump header or tubing to a peristaltic pump of a dialysis machine. The cover includes an integral raceway for engaging the pump header as a rotor of the peristaltic pump rotates along the integral raceway. The cover is pivoted away from the dialysis machine to separate the raceway from the rotor and provide substantial access for loading the pump header about the rotor. The cover is then closed to secure the pump header in place and properly position the integral raceway in relation to the pump rotor. If the pump header is connected to a blood tubing set, the cover also secures the blood tubing set in position against the dialysis machine. A detachable hinge connects the cover to the dialysis machine to allow the cover to be completely detached from the dialysis machine. The detachable cover provides complete access for cleaning the area surrounding the peristaltic pump rotor and the location where the blood tubing set is located.

Blood processing method and apparatus with disposable cassette

A fluid flow apparatus includes a peristaltic pump rotor mounted to a deck module assembly. A disposable software set is provided which includes a cassette which has a primary flexible tube and a pump platen adjacent to which the primary flexible tube resides. Tubing with blood processing bags are coupled to the manifold along with the input port of the rotor of a disposable blood processing centrifuge bowl. The cassette is removably secured to the hardware apparatus such that the flexible tube contacts both the platen of the cassette and the rollers of the pump rotor. The pump rotor is rotated to induce a fluid flow through the primary flexible tube. The software set also includes a three-to-one manifold which connects the primary tube to a plurality of secondary flexible tubes. Fluid flow through the secondary flexible tubes is controlled by a plurality of pinch valves which pinch the secondary tubes closed against closing surfaces on the cassette. A deck module assembly allows a user to properly secure the cassette relative to the pump rotor and the pinch valves.

Integrated automatic blood collection and processing unit

A system for automatically collecting and separating whole blood into its components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.

Device for the treatment of a medical fluid

The invention relates to a device for the treatment of a medical fluid, said device consisting of a permanently installed fluid treatment machine and a cassette with fluid-carrying channels as well as an elastic matt placed between these two items, with matt channels recessed in said elastic matt. The matt channels are provided with slits. Via the matt channels, an optimised vacuum distribution takes place and the slits serve the purpose of removing air between the cassette and the fluid treatment machine.

Device for treating a medical liquid

The invention relates to an apparatus for the treatment of a medical liquid comprising a liquid treatment machine and a cassette insertable therein substantially made of a rigid base body of the cassette with fitted chambers and passages and a foil covering them. In accordance with the invention, actuators and sensors are arranged in the liquid treatment machine for the operation of the apparatus with the inserted cassette such that cassettes are insertable in different integration shapes.

Peristaltic pump tube holder with pump tube shield and cover

A peristaltic pump tube holder includes a body that supports a flexible tubing loop in an erect, outwardly bowed position extending from the body for engagement with a peristaltic pump rotor. The holder also includes a receptacle carrying the body. The receptacle includes a wall forming a chamber that covers the flexible tubing loop and at least partially shields it from contact. The chamber further serves, during engagement between the tubing loop and a peristaltic pump rotor, as a cover for the peristaltic pump rotor.

Integrated cassette for controlling fluid having an integral filter

An apparatus controls movement of fluids during an extracorporeal blood treatment session. A hollow cassette enclosure has a plurality of fluid input ports for receiving fluids into the enclosure and a plurality of fluid output ports for expelling fluids from the enclosure. Internal fluid passageways disposed within the hollow enclosure are provided for coupling together the fluid input ports, and the fluid output ports. At least one internal valve is disposed within the hollow enclosure for controlling movement of the fluid within the hollow enclosure. A filter is integrated into the cassette to filter the blood passing therethrough.

Device for treating a medical liquid

An apparatus for the treatment of a medical liquid has a liquid treatment machine and a cassette that is insertable in the machine. The cassette has a rigid base body with fitted chambers and passages and a foil that covers the chambers and passages. Actuators and sensors are arranged in the liquid treatment machine for the operation of the apparatus with the inserted cassette such that cassettes are insertable in different integration shapes.

具有对准闩锁且具有改进的耐倾斜性的流体盒、以及血液治疗设备

本发明涉及一种流体盒，例如一种血液治疗盒(1000)，其具有被实施为硬质部(1)的盒本体且视需要具有膜(3)，所述膜(3)连接至所述硬质部(1)并至少局部地覆盖所述硬质部(1)，其中所述硬质部(1)包括至少一个第一对准器件(504)及第二对准器件(505)，所述第一对准器件(504)及第二对准器件(505)视需要被布置或附装在所述流体盒的相对的第一侧及第二侧上。另外，本发明涉及一种血液治疗设备(5000)。

Flüssigkeitskassette mit kipptoleranter zentrierverrastung sowie blutbehandlungsvorrichtung

Die vorliegende Erfindung betrifft eine Flüssigkeitskassette, z. B. eine Blutbehandlungskassette (1000), mit einem als Hartteil (1) ausgestalteten Kassettenkörper und optional einer Folie (3), welche mit dem Hartteil (1) verbunden ist und das Hartteil (1) zumindest abschnittsweise abdeckt, wobei das Hartteil (1) wenigstens eine erste Zentriervorrichtung (504) und eine zweite Zentriervorrichtung (505) aufweist, welche optional an gegenüberliegenden ersten und zweiten Seiten der Flüssigkeitskassette (1000) angeordnet oder diesen zugeordnet sind. Die Erfindung betrifft ferner eine Blutbehandlungsvorrichtung.

Casete de fluido con seguro de alineacion que tiene una tolerancia a la inclinacion mejorada, asi como un aparato de tratamiento de la sangre.

La presente invención se refiere a un casete de fluido, por ejemplo, un casete (1000) de tratamiento de la sangre que tiene un cuerpo de casete incorporado como una parte (1) dura y, opcionalmente, una película (3) que está conectada a la parte (1) dura y al menos parcialmente cubre la parte (1) dura, en donde la parte (1) dura comprende al menos un primer dispositivo (504) de alineación, y un segundo dispositivo (505) de alineación que están dispuestos opcionalmente en el primero y segundo lados opuestos del casete de fluido o están unidos sobre el mismo. La invención se refiere además a un aparato (5000) de tratamiento de la sangre.

Fluid cassette with alignment latching having an improved tilt-tolerance as well as a blood treatment apparatus

The present invention relates to a fluid cassette, e.g. a blood treatment cassette (1000) comprising a cassette body, which is designed as a hard part (1), and optionally a film (3), which is connected to the hard part (1) and covers the hard part (1) at least in sections thereof, the hard part (1) comprising at least a first centering device (504) and a second centering device (505) which are optionally arranged on or associated with opposite first and second sides of the fluid cassette (1000). The invention further relates to a blood treatment device.

틸트-내성 센터링 로킹이 되는 유체 카세트, 및 혈액 처리 장치

본원은 의료 유체 카세트, 예컨대 혈액 처리 카세트(1000)로서, 경질 부품(1)으로서 구현된 카세트 바디, 및 선택적으로 필름(3)을 구비하고, 상기 필름(3)은 상기 경질 부품(1)과 연결되어, 상기 경질 부품(1)을 적어도 부분적으로 덮고, 상기 경질 부품(1)은, 상기 유체 카세트의 서로 반대인 제1 및 제2 면 상에 선택적으로 배열되거나 면들 위에 부착되는 적어도 하나의 제1 정렬 디바이스(504) 및 제2 정렬 디바이스(505)를 포함하는, 혈액 처리 카세트(1000)에 관한 것이다. 본원은 추가로 혈액 처리 장치(5000)에 관한 것이다.

Fluid processing systems using extracorporeal fluid flow panels oriented within a cartridge

A first flow path (78) is defined within a first panel that forms part of an extracorporeal fluid circuit (56). A second flow path is defined within a second panel that also forms a part of the extracorporeal fluid circulation. The first and second panels are oriented in a fluid processing cartridge (18) for mounting as an integrated unit on a fluid processing machine (16) and for removal as an integrated unit from the fluid processing machine.

Extracorporeal blood processing methods and apparatus

This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.

血袋系统和固定盒

本发明提供一种血袋系统和固定盒。在安装于离心分离装置内的血袋系统中，过滤器在保管时和使用时能以不同的适当朝向设置，并且第一管、第二管和过滤器在使用过程中分别以适当朝向配置。血袋系统(10a)包括：用于血沉棕黄层的离心分离的BC容纳袋(54)、用于从自BC容纳袋(54)输送的澄清液中去除白细胞的过滤器(56)、用于储备通过了过滤器(56)的澄清液的血小板保存袋(58)、连接BC容纳袋(54)与过滤器(56)的入口(56a)的第一管(60)、连接血小板保存袋(58)和过滤器(56)的出口(56b)的第二管(62)、待固定在离心分离装置中的固定盒(50a)、用于保持过滤器(56)的附件(142)和能够关于沿周向的轴线相对于固定盒(50a)倾斜的铰接部(140)。

具有对准闩锁且具有改进的耐倾斜性的流体盒、以及血液治疗设备

本发明涉及一种流体盒，例如一种血液治疗盒(1000)，其具有被实施为硬质部(1)的盒本体且视需要具有膜(3)，所述膜(3)连接至所述硬质部(1)并至少局部地覆盖所述硬质部(1)，其中所述硬质部(1)包括至少一个第一对准器件(504)及第二对准器件(505)，所述第一对准器件(504)及第二对准器件(505)视需要被布置或附装在所述流体盒的相对的第一侧及第二侧上。另外，本发明涉及一种血液治疗设备(5000)。

Dialysis system including heparin injection

A dialysis system includes a dialysis instrument including a blood pump actuator, a dialyzer, a heparin pump, and a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument, the blood pumping portion including an inlet and an outlet, the inlet of the blood pumping portion of the disposable cassette positioned and arranged to receive blood from an arterial line of an extracorporeal circuit, the outlet of the blood pumping portion of the disposable cassette positioned and arranged to deliver the blood to the dialyzer and to receive heparin from the heparin pump.