ПОДГОТОВИТЕЛЬНАЯ АНТИКОАГУЛЯНТНАЯ ЛИНИЯ ДЛЯ ЗАБОРА КРОВИ

Группа изобретений относится к медицинской технике. Способ уменьшения собранного объема во время сбора компонентов крови включает подготовку и регулировку оборудования по переработке крови антикоагулянтным раствором, включая синхронное закачивание антикоагулянта до обнаружения датчиком в заборной/возвратной линии. Далее подтверждают операции закачивания и геометрической конфигурации трубопровода путем сравнения количества оборотов двигателя насоса, необходимого для продвижения антикоагулянтного раствора между воздушными/жидкостными датчиками к заданным ожидаемым результатам на основе известной производительности насоса и длины трубопровода. Подтверждают надлежащую функцию насосов и колпачка на устройстве венозного доступа путем удерживания одного насоса в фиксированном состоянии и перемещения другого при сравнении наблюдаемого изменения давления на датчике давления с ожидаемым изменением на основе соотношения объема жидкости с воздухом, ожидаемого в линиях. Уведомляют оператора о любых ...

COMPUTER-CONTROLLED MEDICAL CARE SYSTEM

KALIBRIERUNG MEHRERER PUMPEN EINES FLÜSSIGKEITSSTRÖMUNGSSYSTEMS

Method of removing blood from extracorporeal blood circulation for treatment device for extracorporeal blood treatment of patient after completing blood treatment session, involves introducing substitute fluid in extracorporeal circulation

The method involves introducing substitute fluid in an extracorporeal circulation (1000). The substitute fluid is conveyed for simultaneous discharge of blood both from an arterial line section (1) and from a venous line section (3) of the extracorporeal blood circulation. The blood is conveyed under simultaneous operation of a blood pump (13) and a conveyor from the extracorporeal circulation. Independent claims are also included for the following: (1) a treatment device with a storage unit; and (2) a tubing system for use in blood removing method.

Kombinierter Halter und Anschluss für einen Dialysator

KUENSTLICHE LUNGE VOM HOHLFASERTYP.

Dialysevorrichtung und Verfahren zum Reinigen und Befüllen derselben

Method of operating fluid flow transfer apparatus

A fluid flow chamber cassette that can be mounted with either its front wall or rear wall against a supporting machine and has a flexible tube that extends from a sidewall and forms a loop that is symmetrical about a loop axis that is transverse to the side wall so that the loop will be acted upon by a pump roller on the machine both when the front wall is against the machine and when the rear wall is against the machine. Also disclosed is automatically fixing the initial liquid levels and amounts of air in venous and arterial chambers of fluid flow transfer device apparatus by having the arterial chamber inlet enter the arterial chamber at a position higher than the arterial chamber outlet, having the venous chamber inlet enter the venous chamber at a position higher than the venous chamber outlet, and priming the apparatus by causing reverse flow, so that the liquid rises in the venous and arterial chambers to the level of the entrances of the inlets. Also disclosed is sensing pressure ...

Modular home dialysis system - debubblers

An apparatus for removing air bubbles from blood is disclosed. The debubbler comprises front and rear covers (1002, 1008 respectively) with a fluid circuit board (1004) arranged between the two covers. A blood chamber is defined between cover (1002) and circuit board (1004) and an air chamber is defined between covers (1008) and circuit board (1004). A microporous membrane (1006) separates the blood and air chambers. A support means (1024) supports membrane (1006) from the air side of the membrane. A blood pressure sensor is provided between covers (1002, 1008). The debubbler has a blood inlet port (1022) and a blood outlet port (1020) for conducting blood to and from the blood chamber. An air port (1012) is provided in communication with the air chamber, to allow air passing through membrane (1006) to escape.

Portable dialysis system

A dialysis system 10 comprising a dialysis machine 20 and a ater purification system 30. The water purification system 30 comprising a pre-treatment system 40 and a primary treatment system 80. The water purification system 30 is provided within a portable unit 90 defining an enclosure. The dialysis machine 20 is removably provided on an upper surface of the enclosure of the portable unit 90. The pre-treatment system may be arranged on a removable panel and may comprise a fluid path including a particulate filter and a primary and secondary carbon filter. The primary treatment system may be a reverse osmosis machine or a deionisation system. The water purification system may also comprise an endotoxin retentive filter and an ultraviolet light system. A method of forming this dialysis system is also provided.

Modular home dialysis system

DEVICE FOR THE SUPPLY A EXTRAKORPORALEN OF A BLUTKREISLAUFS

ARRANGEMENT FOR ON-LINE RINSING AND FILLING OR FREE RINSES A EXTRAKORPORALEN OF A BLUTKREISLAUFS OF DIALYSIS MACHINES

PROCEDURE FOR EMPTYING A BLUTKREISLAUFS IN A DEVICE FOR EXTRAKORPORALEN THE BLOOD TREATMENT

BLOOD TREATMENT EQUIPMENT AND PROCEDURE FOR EMPTYING ONE BLUTSCHLAUCHSATZES BLOOD TREATMENT EQUIPMENT

PROCEDURE FOR ON-LINE RINSING AND FILLING A EXTRAKORPORALEN OF A BLUTKREISLAUFES OF DIALYSIS MACHINES

FILTRATION DEVICE FOR THE DISTANCE OF LEUKOCYTES

PROCEDURE AND DEVICE FOR THE FLUSHING OF A DIAPHRAGM APPARATUS

CARTRIDGE FOR STEERING AND PUMPING FLUIDS

PROCEDURES FOR CALIBRATING A IN OF A PERISTALTI PUMP USED PUMPING SEGMENT AS WELL AS MEDICAL MACHINE TO THE EXECUTION OF THE PROCEDURE

Single needle recirculation system for harvesting blood components

Spike port for medical solution bag assembly and related methods

CARDIOPLEGIA ADMINISTRATION SET

UNITARY HEAT EXCHANGER AND DEBUBBLER

Automatic priming and scheduling for dialysis systems

A method including automatically performing at least one integrity test on a dialysis machine after powering on the dialysis machine, wherein the at least one integrity test is selected from the group consisting of a battery test, a dialysate conductivity test, and a dialysate temperature test. The method also includes presenting, on a display of the dialysis machine, a first set of instructions for priming the dialysis machine after completing the at least one integrity test.

On demand and post-treatment delivery of saline to a dialysis patient

Apparatus for use in a dialysis system are disclosed including an apparatus- for delivering saline during dialysis treatment, an apparatus for delivering saline to a patient after dialysis treatment has ended, and an apparatus for alerting a patient that dialysis treatment is about to end. In the apparatus for delivering saline during dialysis treatment, a controller is configured to automatically deliver saline in response to a request. In the apparatus for delivering saline to a patient after dialysis treatment has ended, a controller is configured to automatically deliver saline after dialysis treatment has concluded, but before the patient is disconnected in response to a request. In the apparatus for alerting a patient that dialysis treatment is about to end, a controller is configured to monitor a dialysis treatment and activate an alarm when treatment is about to end.

Method for filling and rinsing a set of blood lines

The invention relates to a method for filling and rinsing a set of blood lines, comprising a pump segment for a blood pump, an arterial line connected to an input of a dialysis machine and a venous line connected to the output of a dialysis machine, by means of a substitute line. Said method comprises the steps of connecting the arterial line to the venous line and connecting both lines to a rinse port, connecting the substitute line to a substitute port, opening the rinse port, filling the arterial and venous line, rinsing the arterial and venous line, closing the rinse port, circulating the substitute in the circuit of arterial line, dialysis machine, and venous line by means of the blood pump, characterised in that the filling and/or rinsing of the venous and the arterial line occurs simultaneously wherein substitute is introduced from the substitute line. The invention further relates to a set of blood lines.

Hemodial ysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Hemodial ysis system

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

Method and apparatus for priming an extracorporeal blood circuit.

A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.

Automatic priming of blood sets

Priming system and method for dialysis systems

System and method for cardiac dialysis

A system and method for treating a patient may include implanting an apparatus that includes a tube housing a one-way valve and having first and second surfaces. When the apparatus is implanted, the first surface is located inside the right atrium of the patient and the second surface is located on the skin of the patient. When implanted, the apparatus is used for drawing blood from the right atrium and/or providing a liquid to the patient. The apparatus may be designed to be hermetically sealed when disconnected from input and output lines.

MEDICAL SET FOR A DIFFUSION DEVICE

Cardiac recovery

TECHNIQUE FOR EXTRACORPOREAL TREATMENT OF BLOOD

A method for priming a circuit for multiple blood extracorporeal treatments, the circuit comprising : a filtration unit (40) having a primary and a secondary chamber (44, 46) separated by a semipermeable membrane (42) ; a primary circuit comprising a blood access line (34) connected to an inlet of the primary chamber (44) and a blood return line (35) connected to an outlet of the primary chamber (44) ; a collection fluid line (82) connected to the outlet of the secondary chamber (46) the method comprising the steps of : circulating a priming fluid from an end of the blood return line (35) to an end of the blood access line (34) and through the primary chamber (44) for a predetermined priming time ; and when the primary circuit (34, 35) is filled with priming fluid, ultrafiltering priming fluid from the primary chamber (44) into the secondary chamber (46) and circulating priming liquid from the secondary chamber (46) to an end of the collection fluid line (82).

BIOLOGICAL FLUID PROCESSING

Disclosed is a filtration system for the filtration of blood or a blood component, the system comprising a container for containing the blood or the blood component to be filtered, a receiving container for receiving the filtered blood or the blood component, a transfer line communicating between the container for the blood or the blood component to be filtered and the receiving container, a blood filter device capable of filtering the blood or the blood component carried in the transfer line between the container for the blood or the blood component to be filtered and the receiving container, and a gas outlet carried in the transfer line downstream of the filter device and upstream of the receiving container, the gas outlet including (a) a housing, (b) a first microporous membrane having first and second sides and being positioned in the housing with the first side in communication with the transfer line, the first microporous membrane being wettable by the filtered blood or the filtered ...

HEAT STERILIZATION METHOD FOR ARTIFICIAL ORGAN ASSEMBLIES

PERSONAL HEMODIALYSIS SYSTEM

A dialysis machine includes a dialysis instrument having a pump actuator and first and second valve actuators, and a disposable cassette operable with the dialysis instrument, the disposable cassette including a pump portion operable with the pump actuator, first and second valve chambers operable with the first and second valve actuators, the first and second valve chambers communicating fluidly with each other, at least the first valve chamber communicating fluidly with a compliance chamber, the compliance chamber negating a first backpressure due to a pneumatic closing pressure used to close the first valve chamber to help to ensure the pneumatic pressure applied to the first valve chamber will close the first valve chamber against a second backpressure from an existing closure of the second valve chamber.

PUMP MONITOR FOR PHOTOACTIVATION PATIENT TREATMENT SYSTEM

PUMP MONITOR FOR PHOTOACTIVATION PATIENT TREATMENT SYSTEM A preferred patient blood treatment system for the photoactivation of reagents in contact with a patient's blood employs an infusion pump for adding anti-coagulation reagent to the blood during extracorporeal operations. The infusion pump is preferably driven by a stepper motor and monitored by a periodic photo chopper employing a plurality of sensors. The spacing of the sensors and the spacing of the photo choppers work in concert to detect rotation of the stepper motor and to discriminate such from stutter or other characteristic nonrotational faults associated with stepper motors.

SYSTEM AND METHOD FOR CARDIAC DIALYSIS

A system and method for treating a patient may include implanting an apparatus that includes a tube housing a one-way valve and having first and second surfaces. When the apparatus is implanted, the first surface is located inside the right atrium of the patient and the second surface is located on the skin of the patient. When implanted, the apparatus is used for drawing blood from the right atrium and/or providing a liquid to the patient. The apparatus may be designed to be hermetically sealed when disconnected from input and output lines.

TECHNIQUE FOR EXTRACORPOREAL TREATMENT OF BLOOD

A method for priming a circuit for multiple blood extracorporeal treatments, the circuit comprising : a filtration unit (40) having a primary and a secondary chamber (44, 46) separated by a semipermeable membrane (42) ; a primary circuit comprising a blood access line (34) connected to an inlet of the primary chamber (44) and a blood return line (35) connected to an outlet of the primary chamber (44) ; a collection fluid line (82) connected to the outlet of the secondary chamber (46) the method comprising the steps of : circulating a priming fluid from an end of the blood return line (35) to an end of the blood access line (34) and through the primary chamber (44) for a predetermined priming time ; and when the primary circuit (34, 35) is filled with priming fluid, ultrafiltering priming fluid from the primary chamber (44) into the secondary chamber (46) and circulating priming liquid from the secondary chamber (46) to an end of the collection fluid line (82).

HEMODIALYSIS SYSTEMS AND METHODS

The present invention relates to hemodialysis and similar dialysis systems, including systems and methods that make hemodialysis more efficient, easier, and/or affordable. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air.

Single Needle Recirculation System for Harvesting Blood Components

Modular Home Dialysis System

TECHNIQUE FOR PRIMING AND RECIRCULATING FLUID THROUGH A DIALYSIS MACHINE TO PREPARE THE MACHINE FOR USE

A technique for automatically priming and recirculating sterile fluid through an extracorporeal circuit of a dialysis machine having a blood pump, a dialyzer (54), and a blood tubing set including an arterial line (38) for drawing blood from a patient and a venous line (66) for returning the blood to the patient. The dialysis machine selectively opens and closes clamps (40 and 72) on the arterial and venous lines and further operates a waste valve (106) leading to a waste drain (86). A connector (102) attaches the arterial and venous lines to the waste valve during the priming procedure. The dialysis machine automatically operates the blood pump, the clamps and the waste valve to flush the dialyzer and the blood tubing set with sterile fluid, direct the used fluid down the waste drain and recirculate additional sterile fluid through the extracorporeal circuit.

Removal of Selected Factors from Whole Blood or Its Components

INTEGRATED CASSETTE FOR VALVING, PUMPING AND CONTROLLING MOVEMENT OF FLUIDS

An apparatus controls movement of fluids during an extracorporeal blood treatment session. A hollow enclosure has a plurality of fluid input ports for receiving fluids into the enclosure and a plurality of fluid output ports for expelling fluids from the enclosure. A first roller pump tube is provided for pumping at least one of the fluids through the hollow enclosure during the photopheresis treatment session. Internal fluid passageways disposed within the hollow enclosure are provided for coupling together the fluid input ports, the fluid output ports and the roller pump. At least one internal valve is disposed within the hollow enclosure for controlling movement of the fluid within the hollow enclosure.

MODULAR HOME DIALYSIS SYSTEM

A machine for conducting dialysis of body fluids of a patient. The machine includes integral water preparation and treatment, dialysate preparation, and extracorporeal circuit modules, under computer control from a patient interface and control module. A water pretreatment module with a temperature-controlled mixing valve, an integral water filtration and conditioning unit and a pressure relief with integral water sample removal port supplies water to the machine. The dialysate preparation module includes a substantially non-compliant tank with attached batch chemical bottles and automatic chemical addition and dispersion subsystems. The machine incorporates novel automatic process control techniques to verify the status and integrity of the critical system components, ultrafiltration control, and temperature, pressure and conductivity conditions prior to dialysis.

CONTAINER FOR the WASHING and OPERATING INTEGRATION OF the OPERATION OF CIRCUITS AND FILTERS FOR DIALYSIS AND USE OF SUCH CONTAINER.

СПОСОБ ЗАПРАВКИ И ПРОМЫВКИ КОМПЛЕКТА ТРУБОК ДЛЯ КРОВИ И КОМПЛЕКТ ТРУБОК ДЛЯ КРОВИ

Изобретение относится к способу заправки и промывки комплекта трубок для крови, который включает в себя сегмент насоса для крови, соединённую со входом диализатора артериальную линию и соединённую с выходом диализатора венозную линию через заместительную линию. Способ включает в себя при этом этапы соединения артериальной линии с венозной линией, а также соединение этих обеих линий с промывочным портом, соединение заместительной линии с заместительным портом, открытие промывочного порта, заправку артериальной и венозной линий, промывку артериальной и венозной линий, закрытие промывочного порта, циркуляцию заместителя в контуре из артериальной линии, диализатора и венозной линии, посредством насоса для крови, причём способ отличается тем, что заправка и/или промывка артериальной и венозной линий происходят одновременно, причём заместитель подводится из заместительной линии. Изобретение относится, кроме того, к комплекту трубок для крови.

Connector, medical treatment device, medical functional device and method

The invention relates to a connector (100) for establishing a fluid connection between at least two medical systems, comprising a multi-lumen end section (1) comprising at least one first fluid guide (3) having at least one first lumen (31), provided for receiving and/or guiding a first, medicinal fluid and a second fluid guide (5) having at least one second lumen (51), provided for receiving and/or guiding at least one second fluid which is different from the first. The invention also relates to a medical treatment device, a medical functional device, a method and a control device.

Spike with non-return valve function and filling device for a liquid system, comprising said spike

IRRIGATION SYSTEM FOR USE DURING ARTHROSCOPY

Unité de dialyse comprenant un drain apte à coopérer de façon étanche avec des tubes.

L'unité de dialyse (10) à élimination par le vide d'un sérum physiologique d'amorçage et à circulation sélective du dialysat et autres fluides comprend un drain (32) configuré pour coopérer de façon étanche avec un jeu de tubes (96, 100, 104).

STERILE BLOOD COMPONENT COLLECTION

UNIT OF DIALYSIS INCLUDING/UNDERSTANDING A DRAIN READY TO COOPERATE IN WAY SEALS WITH TUBES.

APPARATUS OF the CASSETTE TYPE USABLE WITH a DEVICE OF TRANSFER OF FLUIDS, PROCESS Of USE Of SUCH an APPARATUS AND APPARATUS TO DETECT the PRESSURE Of a LIQUID

SYSTEM Of IRRIGATION INTENDS TO BE USES DURING a ARTHROSCOPIE

Extracorporeal blood treatment device and method for operating an extracorporeal blood treatment device

체외 혈액 회로 내 기포 제거 방법

... 본 발명은 투석 장치의 체외 혈액 회로의 목표 영역에서 기포를 제거하는 방법에 관한 것으로서, 상기 목표 영역은 유입부를 통해 상기 목표 영역으로 들어가고 유출부룰 통해 다시 목표 영역에서 빠져나가는 세정액에 의해 통과되며, 상기 유입부는 동맥 포트와 구별되고 상기 유출부는 상기 체외 혈액 회로의 정맥 포트와 구별된다. 더 나아가 본 발명은 체외 혈액 회로 및 컨트롤 유닛을 포함하는 투석 장치에 관한 것으로서, 상기 체외 혈액 회로는 세정액을 위한 유입부 및 유출부를 포함하되, 상기 유입부는 동맥 포트와 구별되고 상기 유출부는 상기 체외 혈액 회로의 정맥 포트와 구별되며, 상기 컨트롤 유닛은 본 발명에 따른 방법을 실시하기 위해 구성된다. 또한 본 발명은 상기 투석 치료를 위한 일회용기기에 관한 것으로서, 상기 일회용기기는 동맥 라인, 혈액 펌프의 구성요소들, 투석기 및 정맥 라인을 포함하되, 상기 일회용기기는 상기 동맥 라인 내에 세정액의 상기 유입부를 위한 인터페이스와 상기 정맥 라인 내에 세정액의 상기 유출부를 위한 인터페이스를 포함하고, 상기 유입부를 위한 상기 인터페이스는 동맥 포트와 구별되고 상기 유출부를 위한 상기 인터페이스는 호스 세트의 정맥 포트와 구별된다.

DIALYSIS DEVICE AND METHOD FOR PRIMING DIALYSIS DEVICE

A dialysis device is primed by first holding a dialyzer (2) upside down, contrary to the case of dialysis therapy, and then rotating a blood pump (14) to thereby fill up a blood circuit (3) and the inside of the dialyzer (2) with physiological saline contained in a physiological saline bag (17). By a liquid level-adjusting means (5), air is then supplied, through an atmosphere pathway (6'), a drip chamber (15') of a vein side pathway (12) and the vein side pathway (12), into the upper part of a blood chamber (2C) including a second port (2H) [Fig. 3(b)]. Thus, small air bubbles in the second port (2H) of the dialyzer (2) are combined with the air having been supplied through the drip chamber (15). Next, the air is discharged to the outside of the dialyzer (2) by the physiological saline that is supplied again into the blood chamber (2C). Thus, air bubbles in the blood chamber (2C) of the dialyzer (2) can be surely removed in the priming process.

CATHETER FLUSH AND FILL UNIT

A catheter flush, and fill unit having a connector (2) for connection to a catheter; a non-return valve (8) connected fluidically to the connector (2); a suction branch (3) connected to the non- return valve (8); and a filter (15) downstream from the suction branch (3). More specifically, a delivery branch (5) is located downstream from the suction branch (3), and a further non-return valve (9) connects the delivery branch (5) to the connector (2).

SYSTEMS AND METHODS FOR HANDLING AIR AND/OR FLUSHING FLUIDS IN A FLUID CIRCUIT

Systems and methods handle air and rinsing fluid during fluid processing. The systems and methods eliminate air from a fluid processing system prior to, during, and after use. The systems and methods provide a connector assembly (30) for establishing fluid flow from a fluid source (32). The connector assembly (30) has discrete first and second passages (36, 38) that prevent communication between the fluid in first passage (36) and the fluid in the second passage (38). Prior to system use, the connector assembly (30) may be utilized in a priming function to remove residual air from a fluid circuit prior to use. The connector assembly (30) may also be utilized after use to perform a rinse-back function.

INNOVATIVE PUMPING SYSTEM FOR PERISTAL PUMPS

The invention is a relatively thin wall extruded tubing that in different forms can provide flow regulation for peristaltic pumps, reduce spallation, extend pumping life, provide means to measure inlet and outlet pressure of the peristaltic pump and limits the inlet and outlet pressure generated by peristaltic pumps. A special peristaltic pump designed to take advantage of the unique characteristics of the thin walled tubing forms the new pumping system. The invention has particular usefulness in the medical industry for pumping physiological or nutritional liquids.

PRIMING SYSTEM AND METHOD FOR DIALYSIS SYSTEMS

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.

CALIBRATING PLURAL PUMP FLUID FLOW SYSTEM

A blood constituent processing system (10) uses a disposable plastic fluid flow path (12) into which an anticoagulant must be accurately metered with respect to pumped blood flow. In a preliminary calibration phase, a closed fluid flow path (12) is provided between the anticoagulant pump and the blood pump. One of the pumps is then controlled to inject fluid into such closed path while the other pump is controlled to withdraw fluid from that path at what is nominally an equal fluid flow rate. Changes in fluid pressure within the closed fluid flow path (12) are then monitored (20) and the flow rate of at least one of the pumps is changed as necessary to achieve an approximately constant fluid pressure within the closed fluid flow path (12). The relative pump flow control (22) required to achieve constant pressure may then be taken as a relative flow rate calibration between the two pumps so as to permit subsequent accurate pumped metering of anticoagulant into the pumped blood flow. A similar ...

TUBING FOR EXTRACORPORAL PURIFICATION OF THE BLOOD AND USE THEREOF

Cette tubulure comprend un conduit de circulation extracorporelle en boucle ouverte présentant deux parties, l'une d'extraction du sang à épurer (1), l'autre de retour du sang épuré (2), au moins un conduit (29, 30, 31) pour relier au moins une desdites parties (1, 2) à une source (16, 16') d'une solution de substitution, un piège à bulles (7) situé le long de ladite boucle, un conduit d'évacuation du produit rejeté (28), muni d'un segment conformé pour servir de corps de pompe et des moyens de raccordement (11) pour relier l'une à l'autre, de façon amovible, les extrémités respectives (45, 46) de ladite tubulure de circulation extracorporelle en boucle ouverte (1, 2) pour former une boucle fermée. Le conduit d'évacuation du produit rejeté (28) comporte, en aval dudit segment conformé pour servir de corps de pompe, un détecteur de sang (14), un conduit de liaison (8) s'étendant entre l'extrémité aval dudit segment conformé pour servir de corps de pompe et ledit piège à bulles (7).

AUTOMATIC PRIMING OF BLOOD SETS

L'invention concerne un système de traitement du sang, tel qu'un équipement de dialyse, qu'on peut amorcer en faisant circuler une solution d'amorçage dans un premier sens d'écoulement (44), à travers au moins un des dispositifs (10, 14), aux fins d'amener cette solution à pénétrer dans une chambre en ligne ménagée (64) dans ledit dispositif dans un sens d'écoulement rétrograde par rapport au sens normal de l'écoulement sanguin dans la chambre. De préférence, la chambre en ligne comporte un filtre (65). L'air est simultanément évacué d'un des dispositifs par un orifice de sortie. Dans une autre étape du procédé, de préférence réalisée simultanément, on fait circuler la solution d'amorçage dans un deuxième sens d'écoulement contraire au premier sens d'écoulement, par les dispositifs raccordés, pour poursuivre l'évacuation de l'air par l'orifice de sortie et achever ainsi l'amorçage du système.

Extracorporeal circulation device and control method

An extracorporeal circulation device having high safety without increases in the circuit scale and the power consumption includes a main control unit responsible for control of a motor drive circuit so as to yield a blood flow rate per unit time set by a user. The motor drive circuit applies a drive signal corresponding to the set blood flow rate to a motor. A sub-control unit configured by a field programmable gate array (FPGA) detects the drive signal applied to the motor and monitors whether or not the drive signal falls within an allowable range corresponding to the set blood flow rate. If the drive signal outside the allowable range is applied, the main control unit is deemed to be in an abnormal state and the main control unit is completely stopped. Then, the sub-control unit takes over the subsequent processing.

Extracorporeal blood circuit priming system and method

A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components ...

DIALYSIS SYSTEM INCLUDING CASSETTE WITH PUMPING TUBES

A hemodialysis system includes a blood treatment machine, a blood pump housed by the blood treatment machine, a first dialysate pump housed by the blood treatment machine, a second dialysate pump housed by the blood treatment machine; and a fluid cassette including an upper portion and a lower portion. The fluid cassette further includes a blood pumping tube extending from the upper portion to the lower portion of the fluid cassette, a first dialysate pumping tube extending from the upper portion to the lower portion of the fluid cassette, and a second dialysate pumping tube extending from the upper portion to the lower portion of the fluid cassette.

Method of cleaning and priming dialysis system

A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed-type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

DIALYSIS MACHINE WITH FLUID PUMPING CASSETTE

A dialysis system is disclosed. The example dialysis system includes a housing, a pump actuator housed by the housing, a fluid pumping cassette coupled operably to the housing and including a flexible membrane covering a pump chamber, and a mechanically actuated piston head provided by the pump actuator and positioned to extend towards and away from the fluid pumping cassette. The fluid pumping cassette is positioned such that the flexible membrane of the fluid pumping cassette faces the piston head so that the piston head can push the flexible membrane into the pump chamber of the fluid pumping cassette to expel a fluid from the pump chamber. The example dialysis system also includes a controller programmed to perform a leak test by monitoring a sensed position of the mechanically actuated piston head while the mechanically actuated piston head applies a force to the flexible membrane of the fluid pumping cassette. 1: A dialysis system comprising:a housing;a pump actuator housed by the housing;a fluid pumping cassette coupled operably to the housing and including a flexible membrane covering a pump chamber;a mechanically actuated piston head provided by the pump actuator and positioned to extend towards and away from the fluid pumping cassette, the fluid pumping cassette positioned such that the flexible membrane of the fluid pumping cassette faces the piston head so that the piston head can push the flexible membrane into the pump chamber of the fluid pumping cassette to expel a fluid from the pump chamber; anda controller programmed to perform a leak test by monitoring a sensed position of the mechanically actuated piston head while the mechanically actuated piston head applies a force to the flexible membrane of the fluid pumping cassette.2: The dialysis system of claim 1 , wherein the membrane is moved by the mechanically actuated piston head during the leak test if a leak is present.3: The dialysis system of claim 1 , wherein the controller is programmed to ...

Dialysis system with enhanced features

A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump: first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

In an apparatus for extracorporeal blood treatment, an extracorporeal circuit (6) is connected to a blood chamber (3) of a membrane device (2). A pump (10) displaces a priming fluid from a source of a priming fluid (9) to a drainage (11) for discharging the priming fluid. A control unit (13) is provided with a processor which controls the pump at a preset first flow rate value, and receives from a pressure sensor (12) a first pressure value, compares the first pressure value with a reference pressure value and, on the basis of this comparison, determines whether or not the extracorporeal circuit is of a pediatric type or of an adult type. The invention is particularly useful during a stage of readying a dialysis apparatus.

VOLUME-BASED PRIMING OF DIALYSIS MACHINES

A dialysis system may include a dialysis machine (e.g., a peritoneal dialysis machine) having a fluid system for delivering fluid (e.g., dialysate) to a patient. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to determine volume information for a fluid system of a dialysis machine, wherein the volume information may comprise a patient line volume and an accuracy adjustment volume, and to determine a priming volume to prime the fluid system with a fluid based on the volume information. Other embodiments are described.

Apparatus for extracorporeal treatment of blood and method of priming an extracorporeal blood circuit

An extracorporeal blood treatment apparatus comprises: a blood treatment device (2); an extracorporeal blood circuit comprising a blood withdrawal line (6) and a blood return line (7) coupled to the extracorporeal blood treatment device (2), wherein the blood return line (7) presents a heating zone (14) coupled or configured to be coupled to a blood warmer (15); a blood pump (6) configured to be coupled to a pump section of the blood withdrawal line (6); at least a post-infusion line (13, 13′) connected to the blood return line (7) upstream of the heating zone (14); an air trapping device (9) placed on the blood return line (7) upstream of the heating zone (14).

BLOOD DEPURATOR AND DEPURATING METHOD

A blood depurator and a blood depurating method by which workability can be enhanced at the time of starting blood depuration treatment while intrusion of a large quantity of priming liquid into the body of a patient is avoided and blood circulating on the outside of the body can be returned purely back to the patient. The blood depurator comprises a differential pressure operating means (10) as a means for detecting the fact that priming liquid on the upstream side of a first solenoid valve V1 and in the vicinity of the distal end of a vein side blood circuit (2) has been replaced with blood based on the difference between liquid pressures (differential pressure) at an artery side drip chamber (5) and a vein side drip chamber (6). When replacement is detected by the differential pressure operating means (10), a switch control means (12) switches the first solenoid valve V1 from closed state to open state and switches a second solenoid valve V2 from open state to closed state automatically ...

Method and system for providing priming and restitution liquids for an extracorporeal blood treatment

SYSTEMS AND METHODS FOR REMOVING UNDESIRED MATTER FROM BLOOD CELLS

Systems and methods of collecting blood cells use a first container (16) connected to at least three transfer containers (18, 26, 34). A filtration system (10) is provided with one transfer container (34), which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers (18, 26) are connected to each other, one (18) of which is empty and one (26) or which contains an additive solution (5) for storage of red blood cells. The empty transfer container (18) is used for storage of platelet concentrate, while the container (26) that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution (5) may be separately passed through the filtration system (10) after filtration of the red cells to flush additional red blood cells from the filtration device (40).

Component separation apparatus

DEVICES FOR DETERMINING A FILLING VOLUME OF AN EXTRACORPOREAL BLOOD CIRCUIT

HERZ-ERHOLUNG

VERFAHREN ZUM FUELLEN EINES BLUTSCHLAUCHSYSTEMS EINER HAEMODIALYSEVORRICHTUNG MIT EINER PHYSIOLOGISCHEN KOCHSALZLOESUNG SOWIE VORRICHTUNG HIERZU

Vorrichtung zur extrakorporalen Blutbehandlung mit verbesserter Anordnung einer Blutbehandlungsvorrichtung

Die Erfindung betrifft eine Vorrichtung (1) zur extrakorporalen Blutbehandlung, insbesondere Dialysevorrichtung (1), mit einer Internfluidik für eine Behandlungsflüssigkeit, insbesondere für eine Dialysierflüssigkeit, welche Interfluidik zumindest zwei Flüssigkeitsanschlüsse (20, 21, 22, 23) zum Anschließen eines im Wesentlichen zylinderförmigen Filterelements (2), insbesondere eines Dialysators (2), an die Internfluidik aufweist, um Behandlungsflüssigkeit durch das Filterelement (2) zu leiten, und mit einer Aufnahme (24) zum austauschbaren Halten des Filterelements (2) derart, dass das Filterelement (2) in bestimmungsgemäßer Weise an die Flüssigkeitsanschlüsse (20, 21, 22, 23) der Internfluidik und einer extrakorporale Blutleitung (13) anschließbar ist, wobei die Aufnahme (24) zum Halten des Filterelements (2) derart, dass dessen Zylinderlängsachse (5) im Wesentlichen horizontal ausgerichtet ist, ausgebildet ist.

Extrakorporale Blutbehandlungsmaschine mit Spender und Verfahren zu deren Benutzung

Die Erfindung betrifft eine Extrakorporale Blutbehandlungsmaschine, vorzugsweise Dialysemaschine mit einem Maschinengehäuse. In oder an dem Maschinengehäuse ist ein Montageplatz, vorgesehen und angepasst zum Halten eines separaten Spenders, an- oder ausgeformt. Des Weiteren betrifft die Erfindung ein Verfahren zur Sicherstellung der Handhygiene bei der Verwendung einer extrakorporalen Blutbehandlungsmaschine mit einer elektronischen Steuereinheit. Das Verfahren fordert zur Betätigung des Spenders durch eine Signalvorrichtung, bei wenigstens einem Anwendungsschritt der extrakorporalen Blutbehandlungsmaschine, auf und beendet die Aufforderung nach der Betätigung des Spenders oder einer Overridetaste.

Verfahren zum Entfernen von Blut aus einem extrakorporalen Blutkreislauf für eine Behandlungsvorrichtung nach Beenden einer Blutbehandlungssitzung und Vorrichtung zum Ausführen desselben

Vorgeschlagen wird ein Verfahren zum Entfernen von Blut aus einem extrakorporalen Blutkreislauf (1) für eine Behandlungsvorrichtung zur extrakorporalen Blutbehandlung eines Patienten (3) nach Beenden einer Blutbehandlungssitzung, wobei die Behandlungsvorrichtung (4) wenigstens einen extrakorporalen Blutkreislauf (1) mit einem Leitungsinneren; wenigstens eine Blutpumpe (11) zum Fördern von Blut innerhalb des Leitungsinneren des extrakorporalen Blutkreislaufs (1); und wenigstens eine Fördereinrichtung (17) zum Einbringen und/oder Fördern wenigstens einer Substituatflüssigkeit innerhalb des Leitungsinneren des extrakorporalen Blutkreislaufs (1) aufweist. Das Verfahren umfasst das Eintragen von Luft in das Leitungsinnere des extrakorporalen Blutkreislaufs (1) durch Betreiben der Blutpumpe (11) und das Einbringen von Substituatflüssigkeit in das Leitungsinnere des extrakorporalen Blutkreislaufs (1) durch Betreiben der Fördereinrichtung (17). Ferner wird eine geeignete Vorrichtung (4) angegeben ...

FILTRATIONSVORRICHTUNG ZUR ENTFERNUNG VON LEUKOZYTEN

VORRICHTUNG ZUR AUSSERKOERPERLICHEN SAUERSTOFFANREICHERUNG DES BLUTES UND ZUR BLUTKREISLAUFUNTERSTUETZUNG.

Vorrichtung zum Bilden eines Fluidkreislaufsystems sowie Fluidkreislaufsystem mit einer derartigen Vorrichtung

Eine Vorrichtung (3) zum Bilden eines Fluidkreislaufsystems (1) umfasst eine Zuführleitung (4) mit einem ersten Anschlusselement (5), einen an die Zuführleitung (4) angeschlossenen Sammelbehälter (8), eine Pumpe (11) zum Fördern des Fluides, einen an den Sammelbehälter (8) mittels einer Verbindungsleitung (9) angeschlossenen Bestrahlungsbeutel (10) sowie eine mit dem Bestrahlungsbeutel (10) verbundene Abführleitung (13) mit einem zweiten Anschlusselement (14), wobei sämtliche Komponenten der Vorrichtung (3) unlösbar miteinander verbunden sind.

EINRICHTUNG ZUR FILTRATION VON PLASMA AUS BLUT.

FLUID FLOW CHAMBER CASSETTE ASSEMBLY

Priming system

HEAT STERILISATION METHOD

FLOW/RETURN OF BLOOD CELLS TO A PATIENT/DONOR AFTER CENTRIFUGAL SEPARATION

Method for removing blood from an extracorporeal blood circuit for a treatment apparatus following termination of a blood treatment session, and apparatus for performing said method

A method for removing blood from an extracorporeal blood circuit of a treatment apparatus for the extracorporeal blood treatment of a patient following termination of a blood treatment session, wherein the treatment apparatus includes at least one extracorporeal blood circuithaving a conduit interior; at least one blood pump for conveying blood inside the conduit interior of the extracorporeal blood circuit; and at least one substitute pumpfor introducing or conveying at least one substituate fluid inside the conduit interior of the extracorporeal blood circuit. The method comprises feeding of air into the conduit interior of the extracorporeal blood circuitby operating the blood pump, and introducing substituate fluid into the conduit interior of the extracorporeal blood circuitby operating the substitute pump. In addition, a suitable apparatus is described.

Blood processing filter and method for priming the filter

This invention relates to a blood processing filter including a sheet-like filter element and a flexible container having an internal space divided by the filter element. The container includes first and second container-forming-parts. The first container-forming-part includes an interior filtration space-forming-part and an exterior surrounding space-forming-part that are separated by a first seal-part. The second container-forming-part includes an extension space-forming-part surrounded by the second seal-part and arranged opposite the filter element and the surrounding space-forming-part, without being divided by the first seal-part. A port of the first container-forming-part is provided in the filtration space-forming-part and communicates with an internal space on one side defined by the filter element. The port of the second container-forming-part is provided in the extension space-forming-part and communicates with an internal space on another side defined by the filter element, and protrudes further than an outer surface of the extension space-forming-part.

Method for removing blood from an extracorporeal blood circuit as well as apparatuses

The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or a functional device, each connectable or connected with a blood treatment apparatus for the purpose of blood treatment of a patient. The blood treatment apparatus of the method comprises or is connected with at least one extracorporeal blood circuit with a line having interior portions, the extracorporeal blood circuit comprising at least one arterial line section and at least one venous line section, wherein a first section of the arterial line section is configured to be connected with a second section of the venous line section, and further comprises at least one blood pump for conveying blood within the line interior portions. The method includes the step of operating the blood pump in a second conveying direction which is opposite to a first customary conveying direction. It further relates to corresponding apparatuses.

Cardiopulmonary bypass or cpb monitoring tool

A cardiopulmonary bypass or CPB monitoring tool includes: a preoperative information module; a preoperative calculation module able to estimate a body surface area, blood volume, and theoretical weight; a priming module able to determine priming constitution, volume and flow to achieve a hemodilution target; an operation risk module for calculating operation risk; a drug calculation module able to determine medication doses; a timer module with timers that can be activated during operation; a data collection module with an interface and drivers enabling data collection from a wide variety of extracorporeal pumps and oxygenators during operation; an events module with retroactive manipulation of the time of an event; a printing report generation module; a graphic user interface; and a configuration module.

MEDICAL FUNCTIONAL DEVICE, PROCESS FLUID, AND MEDICAL TREATMENT APPARATUS

A medical functional device, provided and designed for single use in a method for extracorporeally treating the blood of a patient, includes at least one process fluid circuit or sections thereof, each provided for receiving a process fluid, at least one first filter device arranged within the process fluid circuit or a section thereof and at least one second filter device arranged within the process fluid circuit or a section thereof. The present invention further relates to a process fluid and a medical treatment apparatus. 118-. (canceled)19. A medical functional device , provided and designed for single use in a method for extracorporeally treating the blood of a patient , comprising:at least one process fluid circuit or sections thereof, each provided for receiving a process fluid;at least one first filter device arranged within the process fluid circuit or a section thereof; andat least one second filter device arranged within the process fluid circuit or a section thereof.20. The medical functional device according to claim 19 , further comprising:at least one conveying device arranged in the process fluid circuit in order to convey the process fluid within the process fluid circuit or a section thereof.21. The medical functional device according to claim 19 , further comprising:at least one extracorporeal blood circuit or parts thereof.22. The medical functional device according to claim 19 , which is connectable or connected for its use with at least one process fluid source claim 19 , wherein the process fluid source is arranged in flow direction of the process fluid upstream the first filter device.23. The medical functional device according to claim 19 , further comprising:at least one of at least one blocking device, one valve device and one occluding pump arranged in the process fluid circuit downstream the second filter device.24. The medical functional device according to claim 20 , wherein the at least one conveying device is a pump intended for ...

Medical device receptacle filling method and apparatus

An apparatus and method for dispersing fluid from a fluid dispersal line is provided. The method comprises initiating operation of the medical apparatus, determining whether fluid has been dispersed from the medical apparatus via the fluid dispersal line since said initiating occurred, and assessing whether fluid is available in the fluid dispersal line. If fluid has not been dispersed from the medical apparatus since said initiating occurred and fluid is not available in the fluid dispersal line, the method includes distributing a commanded quantity of fluid plus an amount of fluid determined to fill the fluid dispersal line. Otherwise the method disperses only the commanded quantity of fluid.

Controlling an apparatus for fluid transfer to and/or from a subject

A control system ( 23 ) is arranged to control the operation of an apparatus ( 200 ) for extracorporeal blood treatment. The apparatus ( 200 ) comprises an extracorporeal blood circuit ( 20 ) and a connection system (C) for connecting the blood circuit ( 20 ) to the vascular system of a patient. The blood circuit ( 20 ) comprises a blood processing device ( 6 ), and at least one pumping device ( 3 ). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit ( 20 ) to pump blood from the vascular system via the connection system (C) through the blood processing device ( 6 ) and back to the vascular system via the connection system (C). The control system ( 23 ) is operable to obtain measurement data from at least one energy transfer sensor ( 40 ) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit ( 20 ). The control system ( 23 ) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit ( 20 ) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus ( 200 ) for blood treatment, such as a dialysis machine.

FLUID AND AIR HANDLING IN BLOOD AND DIALYSIS CIRCUITS

An air purging method includes: (a) detecting a low fluid level in a blood circuit indicating a high amount of air in the blood circuit; (b) stopping a blood pump; (c) closing a venous patient line; (d) opening a blood circuit air vent valve and a drain valve; and (e) running the blood pump to meter air through the air vent valve and the drain valve to a drain. 1. A blood priming method comprising:(a) running a dialysate pump to pull blood from a patient into an extracorporeal blood circuit in a first direction thereby displacing a priming liquid to a drain until or after blood is detected in the extracorporeal blood circuit; and(b) running a blood pump to pull blood from the patient into the extracorporeal blood circuit in a second direction thereby displacing the priming liquid to the drain until or after blood reaches an air trap in the extracorporeal blood circuit.2. The blood priming method of claim 1 , which includes displacing the priming liquid during (a) and (b) by flowing the priming liquid through a line connecting the extracorporeal blood circuit to the drain so that the priming liquid does not pass through a blood filter.3. The blood priming method of claim 1 , which includes pulling blood through a venous access during (a) and pulling blood through an arterial access during (b).4. The blood priming method of claim 1 , which includes opening an air vent valve to drain to allow the priming liquid to run from an air trap to drain.5. The blood priming method of claim 1 , which includes detecting blood during (a) via a blood presence detector.6. The blood priming method of claim 1 , which includes at least one of: (i) communicating the dialysate pump with the extracorporeal blood circuit via an air vent line; (ii) running the dialysate pump for a number of cycles or for a given time after blood is detected in the extracorporeal blood circuit; or (iii) running the blood pump for a number of cycles or for a given time after blood reaches the air trap.7. A ...

Method and system for detecting or verifying a blood circuit connected to an extracorporeal blood treatment console

A method to determine a type of blood circuit attached to an extracorporeal blood treatment console including: pumping a liquid through a blood passage of the blood circuit, sensing a first pressure in: the blood passage while the passage is closed and pumping stopped, pumping an additional amount of the liquid into the blood passage while the blood passage is and remains closed and thereafter sensing a second pressure, and determine a dimensional characteristic of a fluid passage in the blood passage based on the additional amount of the liquid and the second pressure.

Devices, systems, and methods for cleaning, disinfecting, rinsing, and priming blood separation devices and associated fluid lines

Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.

Blood perfusion system

An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.

Priming anticoagulant line for blood extraction

Methods and devices are described for reducing anticoagulant dilution of collected blood components during blood collection.

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT COMPRISING AN IMPROVED ARRANGEMENT OF A BLOOD TREATMENT DEVICE

A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned. 111.-. (canceled)12. A device for extracorporeal blood treatment , the device comprising:(a) an internal fluidic system for a treatment liquid, said internal fluidic system having at least two liquid connectors for connecting a cylindrical filter element to the internal fluidic system for passing a treatment liquid through the filter element, and(b) a mounting configured to hold the filter element such that the filter element can be connected to the at least two liquid connectors of the internal fluidic system and to an extracorporeal blood line, wherein the mounting is oriented such that a cylinder longitudinal axis of the filter element is substantially horizontally aligned when the filter element is held by the mounting.13. The device according to claim 12 , wherein the mounting has at least one horizontally aligned contact surface for the filter element.14. The device according to claim 12 , wherein the filter element is rotatable about its cylinder longitudinal axis while in the mounting.15. The device according to claim 12 , wherein the mounting can be pivoted on the device about a horizontal axis in an angular range a of about ±5° about the ...

Systems and methods for optimization of plasma collection volumes

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

DIALYSIS SYSTEM HAVING INDUCTIVE HEATING

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat. 1. A dialysis fluid system comprising:a dialysis fluid inlet;a dialysis fluid outlet;a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the dialysis fluid outlet,', 'a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and', 'a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding dialysis fluid to heat., 'an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including'}2. The dialysis fluid system of claim 1 , wherein the fluid flowpath and the conductive heater element are located within a heater housing in fluid communication with the dialysis fluid inlet and the dialysis fluid outlet.3. The dialysis fluid system of claim 2 , ...

Improved dialyzer holder and improved airless bloodline priming method

The present invention relates to a dialyzer holder to attach a dialyzer to a dialysis machine. During priming of a bloodline prior to a dialysis treatment, the dialyzer holder grips a dialyzer in approximately the center of the dialyzer, but allows movements of the dialyzer in an arc motion using two axes of rotation. The holder enables the dialyzer to move to a position where air can be primed from the dialyzer and, because the dialyzer can move toward the dialysis machine, this motion eliminates stress on the tubing connected to the bottom and top of the dialyzer and reduces the length of bloodline tubing necessary to accommodate dialyzer movement. The dialyzer holder incorporates an attachment point for a venous chamber for use during the priming procedure, enabling the venous chamber to move with the dialyzer, further reducing the tubing between the dialyzer and the venous chamber.

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

METHOD FOR PRODUCING CELL CONCENTRATE, AND CELL SUSPENSION TREATMENT SYSTEM

In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit. 1. A cell suspension treatment system comprising:a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port;a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane,a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, the circuit being constituted by an introduction communication tube communicating the circulation inlet port of the storage container and the cell suspension introduction port of the cell suspension treatment device and a lead-out communication tube communicating the cell suspension lead-out port of the cell suspension treatment ...

APPARATUS FOR PERFORMING HAEMODIALYSIS

An apparatus for performing haemodialysis on a patient comprises: first blood transfer means () for selectively withdrawing blood from a patient and storing it in a first storage portion (); second blood transfer means () for removing filtered blood from a filtration device () and storing it in a second storage portion (); and a fluid measurement system () for periodically measuring the respective volumes of blood in the first and second storage portions; adding the volume of blood in the first storage portion to the volume of blood in the second storage portion at that time in order to calculate the total volume of blood within the first and second storage portions at that time; and comparing the total measured volumes of blood within the first and second storage portions measured over a predetermined time interval to calculate the volume of fluid removed from the blood during that predetermined time interval. 2. An apparatus as claimed in claim 1 , wherein said fluid measurement system further comprises a fluid control system for controlling the apparatus such that over a predetermined period of time claim 1 , a predetermined volume of fluid is removed from the blood of the patient.3. An apparatus as claimed in claim 1 , wherein the first blood transfer means comprises a first syringe having a first plunger defining a first chamber claim 1 , and said second blood transfer means comprises a second syringe having a second plunger defining a second chamber.4. An apparatus as claimed in claim 3 , wherein said fluid measurement system further comprises a fluid control system for controlling the apparatus such that over a predetermined period of time claim 3 , a predetermined volume of fluid is removed from the blood of the patient claim 3 , and wherein said fluid measurement system comprises a drive means for measuring and controlling the amount of blood in said first and second chambers of said first and second syringes respectively.5. An apparatus as claimed in claim ...

DIALYSIS SYSTEM INCLUDING DISPOSABLE CASSETTE

A dialysis system includes a dialysis machine having a pump actuator, a valve actuator and a sorbent device, and a disposable cassette including (i) a housing having a dialyzer inlet port, a dialyzer outlet port, a pump portion configured to operate with the pump actuator, a valve portion configured to operate with the valve actuator, a venous port, and an arterial port, (ii) at least one dialyzer in fluid communication with the housing, the at least one dialyzer including a dialysate inlet, and a dialysate outlet; (iii) an arterial line for connecting to a patient, the arterial line connected to and extending externally from the arterial port of the housing; (iv) a venous line for connecting to a patient, the venous line connected to and extending externally from the venous port of the housing; and (v) first and second dialysate fluid connections in fluid communication with the sorbent device. 1: A dialysis system comprising: a blood pump actuator,', 'a dialysate pump actuator,', 'a blood valve actuator,', 'a dialysate valve actuator, and', 'a pressure sensor;, 'a dialysis machine including'}a sorbent device; a dedicated dialyzer inlet port,', 'a dedicated dialyzer outlet port,', 'a blood pump portion operable with the blood pump actuator,', 'a dialysate pump portion operable with the dialysate pump actuator,', 'a blood valve portion operable with the blood valve actuator,', 'a dialysate valve portion operable with the dialysate valve actuator,', 'a pressure sensor portion operable with the pressure sensor, and', 'a recirculation line in fluid communication with the sorbent device;, 'a disposable cassette including'} a dialysate inlet, and', 'a dialysate outlet;, 'a dialyzer including'}a first dialysate fluid connection extending from the dedicated dialyzer inlet port of the disposable cassette to the dialysate inlet of the dialyzer; anda second dialysate fluid connection extending from the dedicated dialyzer outlet port of the disposable cassette to the dialysate ...

Dialysis system including automatic priming

A hemodialysis system comprising: a source of priming fluid; an extracorporeal circuit including an arterial line, a venous line, and a drip chamber; a level sensor operable with the drip chamber; a reversible blood pump operable with the extracorporeal circuit; a connection between the arterial and the venous line; and a priming sequence in which priming fluid from the source is pumped in a reverse pump direction through the extracorporeal circuit and reversibly in a normal pump direction through the extracorporeal circuit, wherein an output from the level sensor is used to determine when to stop pumping in at least one of the directions.

Spike with non-return valve function and filling device of a liquid system with spike

Disclosed is an anti-contamination device for preventing contamination of a fluid stored in a fluid container with a spike and a manually operable fluid blocking mechanism arranged directly downstream of the spike. A non-return valve is arranged between the spike and the fluid blocking mechanism, and that valve is adapted to allow only a flow from the spike in the direction of the manually operable fluid blocking mechanism.

DIALYSIS SYSTEM WITH BALANCE CHAMBER PRIME AND RINSEBACK

A dialysis system includes an extracorporeal circuit, a dialysis fluid circuit including first and second balance chambers, a fresh dialysis fluid pump in fluid communication with first and second fresh compartments of the first and second balance chambers, respectively. The first and second fresh compartments are in fluid communication with a fresh dialysate fluid inlet of the dialyzer, and a used dialysis fluid pump is in fluid communication with first and second spent compartments of the first and second balance chambers, respectively. The system is configured to run a blood rinseback sequence in which (i) at least one of the fresh used dialysis fluid pumps is operated to pump dialysis fluid through the dialyzer and into the extracorporeal circuit and (ii) the blood pump is operated to push blood back to a patient connected to the extracorporeal circuit. 1: A dialysis system comprising:an extracorporeal circuit including a blood pump;a dialyzer in communication with the extracorporeal circuit, the dialyzer including a fresh dialysis fluid inlet and a used dialysis fluid outlet; a first balance chamber including a fresh compartment and a used compartment, the fresh compartment of the first balance chamber in fluid communication with the fresh dialysis fluid inlet of the dialyzer,', 'a second balance chamber including a fresh compartment and a used compartment, the fresh compartment of the second balance chamber in fluid communication with the fresh dialysis fluid inlet of the dialyzer,', 'a fresh dialysis fluid pump in fluid communication with the fresh compartment of the first balance chamber and the fresh compartment of the second balance chamber, the fresh compartment of the first balance chamber and the fresh compartment of the second balance chamber in fluid communication with the fresh dialysate fluid inlet of the dialyzer,', 'a used dialysis fluid pump in fluid communication with the used compartment of the first balance chamber and the used compartment of ...

BLOOD TREATMENT AIR PURGING SYSTEMS

Dialysis systems that remove air from a blood circuit are disclosed herein. In an embodiment, a dialysis system includes a dialysis fluid circuit, a blood circuit including an arterial line, a venous line, and an enclosure in fluid communication with the venous line, the enclosure configured to release air through a hydrophobic vent for priming the blood circuit, a blood pump configured to pump fluid through at least the arterial line, a first valve operable with the arterial line and a second valve operable with the venous line, and a pumping and valving algorithm operated after priming to remove air from the blood circuit to control the first and second valves and the blood pump to replace priming fluid with blood from a patient. 1. A dialysis system comprising:a dialysis fluid circuit; an arterial line,', 'a venous line, and', 'an enclosure in fluid communication with the venous line, the enclosure configured to release air through a hydrophobic vent for priming the blood circuit;, 'a blood circuit including'}a blood pump configured to pump fluid through at least the arterial line;a first valve operable with the arterial line and a second valve operable with the venous line; anda pumping and valving algorithm operated after priming to remove air from the blood circuit to control the first and second valves and the blood pump to replace priming fluid with blood from a patient.2. The dialysis system of claim 1 , wherein the enclosure includes an air trap.3. The dialysis system of claim 1 , wherein the hydrophobic vent communicates with the enclosure via a vent line.4. The dialysis system of claim 1 , wherein the priming fluid includes saline claim 1 , heparin or dialysis fluid.5. The dialysis system of claim 1 , wherein the pumping and valving algorithm controls the first and second valves and the blood pump so that the blood from the patient replaces the priming fluid while both the arterial line and the venous line are connected to the patient.6. The dialysis ...

CARDIOPULMONARY APPARATUS AND METHODS FOR PRESERVING LIFE, PRESERVING ORGAN VIABILITY AND/OR FOR USE DURING PCI AND CABG

Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage deairing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure such as; cardiopulmonary bypass graft surgery, keyhole cardiopulmonary bypass graft surgery, percutaneous angioplasty, percutaneous stent placement, and percutaneous atherectomy, repairing or replacing the heart valve and/or for perfusing an organ or the body of an organ donor to preserve viability of organ(s) for transplantation. 1a) priming a heart-lung machine with a priming liquid in a priming mode;b) switching the heart lung machine from the priming mode to an operational mode;c) connecting a venous blood inlet on the heart lung machine to a vein in the. A method for providing extracorporeal circulation to a patient or organ donor comprising the steps of:d) operating the heart-lung machine in said operational mode to take venous blood from the patient, oxygenate the venous blood, and return oxygenated blood to the patient or organ donor; andwherein:said heart-lung machine comprises a centrifugal pump head having a central inletand a tangential outlet; andsaid central inlet to the centrifugal pump head is oriented vertically upward duringpriming step a) and horizontally during operating step d.patient or organ donor and connecting an arterial blood outlet from the heart lung machine to an artery in the patient or organ donor to form a closed extracorporeal blood circulation in fluid contact with the patient or organ donor's circulatory system; This application is a continuation in part of:Also incorporated by reference in this application are the entire disclosures of each of the following: U.S. patent application Ser. No. 11/284,515 filed Nov. 22, 2005 entitled Apparatus For Making Extracorporeal Blood Circulation Available; European Patent Application No. EP 04 027 855.8 filed on Nov. 24, 2004 entitled Vorrichtung zur Bereitstellung ...

Cap for syringe needle and device for dialysis circuit priming

A needle cap and a dialysis circuit priming device with increased safety and convenience in the cleaning and priming of a blood circuit are provided. According to the present invention, a needle cap is provided including two needle connecting parts, and a flow path connecting the two needle connecting parts. A dialysis circuit priming device is also provided including two needles, two needle connecting parts each arranged with the two needles respectively, and a flow path for connecting the two needle connecting parts.

Systems and methods for automated recovery of white blood cells after producing a leuko-reduced blood product

The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.

METHOD FOR REMOVING BLOOD FROM AN EXTRACORPOREAL BLOOD CIRCUIT AS WELL AS APPARATUSES

The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or a functional device, each connectable or connected with a blood treatment apparatus for the purpose of blood treatment of a patient. The blood treatment apparatus of the method comprises or is connected with at least one extracorporeal blood circuit with a line having interior portions, the extracorporeal blood circuit comprising at least one arterial line section and at least one venous line section, wherein a first section of the arterial line section is configured to be connected with a second section of the venous line section, and further comprises at least one blood pump for conveying blood within the line interior portions. The method includes the step of operating the blood pump in a second conveying direction which is opposite to a first customary conveying direction. It further relates to corresponding apparatuses. 115-. (canceled)16. A blood-handling system comprising:a functional device comprising a venous line section and a venous addition point communicating therewith, wherein the venous addition point is at least one of configured or provided to be connected with an arterial needle connection of an arterial line section of an extracorporeal blood circuit.17. The blood handling system according to claim 16 , further comprising:the extracorporeal blood circuit, wherein the arterial needle connection or a different section of the arterial line section of the extracorporeal blood circuit is configured to be connected with the venous addition point of the functional device.1820-. (canceled) This application claims the benefit of U.S. Provisional Patent Application No. 61/512,930 filed on Jul. 29, 2011 and German Patent Application No. 10 2011 108 777.3, filed Jul. 29, 2011, both of which are herein incorporated by reference in their entireties.The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or from a ...

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

A control system () is arranged to control the operation of an apparatus () for extracorporeal blood treatment. The apparatus () comprises an extracorporeal blood circuit () and a connection system (C) for connecting the blood circuit () to the vascular system of a patient. The blood circuit () comprises a blood processing device (), and at least one pumping device (). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit () to pump blood from the vascular system via the connection system (C) through the blood processing device () and back to the vascular system via the connection system (C). The control system () is operable to obtain measurement data from at least one energy transfer sensor () arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (). The control system () is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit () to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus () for blood treatment, such as a dialysis machine. 131-. (canceled)32. An apparatus for extracorporeal blood treatment , comprising:an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to the vascular system of a patient, the extracorporeal blood circuit comprising a blood processing device;at least one pressure sensor configured to sense pressure pulses from a physiological pulse generator in the patient;at least one pumping device; and a sensor signal input device to obtain measurement data from the at least one ...

Methods and apparatus for kidney dialysis and extracorporeal detoxification

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.

HEMODIALYSIS SYSTEM

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly. 182.-. (canceled)83. A drain cassette that is connectable to and disconnectable from a front panel of a dialysis unit by a user of the dialysis unit , comprising:a venous connection port for connection to, and fluid communication with, a venous blood line connector that terminates a venous line of a blood circuit assembly;an arterial connection port for connection to, and fluid communication with, an arterial blood line connector that terminates an arterial line of the blood circuit assembly;a fluid channel fluidly connecting the venous connection port and the arterial connection port;a drain outlet port in fluid communication with the fluid channel and arranged to removably couple with a drain connector on the front panel of the dialysis unit; anda valve arranged to control flow in the fluid channel,wherein the valve is arranged to control in the fluid channel to either controllably open and close fluid communication in the fluid channel between the drain outlet port and the venous connection port, or to controllably open and close fluid communication in the fluid channel between the drain ...

DIALYSATE EXTRACTION APPARATUS

A dialysate extraction apparatus which can reliably perform cleaning and disinfecting on an inside of a collection port without extending a separate flow route from an on-off device. The dialysate extraction apparatus includes a dialysate extraction device having an inlet and an outlet which can circulate a liquid, and having a collection port which can collect the circulating liquid; and a cap which is attachable to and detachable from the collection port of the dialysate extraction device and which can turn on and off the collection port. When the cap is attached, the collection port defines a guide route which guides the liquid introduced from the inlet to a tip a side of the collection port, and a discharge route which discharges the liquid guided by the guide route to the outlet side. 1. A dialysate extraction apparatus comprising:a dialysate extraction device having an inlet and an outlet which are connected to a flow route of a liquid and which can circulate the liquid, and having a collection port which can collect the circulating liquid; andan on-off device which is attachable to and detachable from the collection port of the dialysate extraction device and which can turn on and off the collection port,wherein in a state where the on-off device is attached, the collection port defines a guide route which guides the liquid introduced from the inlet to a tip side of the collection port, and a discharge route which discharges the liquid guided by the guide route to the outlet side.2. The dialysate extraction apparatus according to claim 1 ,wherein the dialysate extraction device has a cylindrical outer peripheral wall which covers an outer periphery of the collection port, andwherein the on-off device includes a sealing device which seals between the on-off device and an outer peripheral surface of the outer peripheral wall or between the on-off device and a tip surface.3. The dialysate extraction apparatus according to claim 1 ,wherein the inside of the ...

FILLING AND RECIRCULATION DEVICE FOR A LIQUID SYSTEM OF AN EXTRACORPOREAL BLOOD TREATMENT DEVICE

Disclosed is a filling and recirculation device of a fluid conducting system for blood treatment which has a fluid connector and a three-dimensional four-way valve with a first valve plane on which an inlet connector for the fluid container, an arterial line connector, and a valve-internal coupling connector are arranged and a second valve plane on which an outlet connector and a venous line connector are arranged. The venous line connector is permanently connected with the valve-internal coupling connector. A manually operable valve rotary piston of the four-way valve has a first control section assigned to the first valve plane and a second control section assigned to the second valve plane. 111-. (canceled)12. Filling and recirculation device of a fluid conducting system of an extracorporeal blood treatment device comprising:a fluid container connector configured for connection with a single fluid connector of a medical fluid container; anda manually operable fluid blocking mechanism positioned downstream of the fluid container connector and configured to remain fluidically connected with the medical fluid container during the entire operation of the filling and recirculation device via the fluid container connector, the fluid blocking mechanism including:a three-dimensional four-way valve with a first valve plane on which an inlet connector for the medical fluid container, an arterial line connector, and a valve-internal coupling connector are arranged and a second valve plane on which an outlet connector and a venous line connector are arranged, the venous line connector permanently fluidically connected with the valve-internal coupling connector of the first plane; anda manually operable valve rotary piston including a first piston control section corresponding to the first valve plane and an axially spaced second piston control section corresponding to the second valve plane, the first and second piston control sections geared relative to each other such that ...

Dialysis systems including therapy prescription entries

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

Methods and apparatus for kidney dialysis and extracorporeal detoxification

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification. 131.-. (canceled)32. A method of dialysis to remove a nonpolar , hydrophobic , and/or protein-bound uremic toxin from the blood or plasma of a subject , comprising subjecting the blood or plasma to an apparatus comprising a body having an inlet and an outlet and defining an interior , the interior including at least one membrane having at least one protein from the lipocalin family bound thereon , the at least one protein being one that binds to the uremic toxin , the apparatus being arranged so that the blood or plasma entering the apparatus contacts the at least one protein from the lipocalin family bound to the at least one membrane in the interior of the apparatus.33. The method of claim 32 , where the at least one protein from the lipocalin family is selected from the group consisting of alpha-1-microglobulin (protein HC) claim 32 , major urinary proteins claim 32 , alpha-1-acid glycoprotein (orosomucoid) claim 32 , aphrodisin claim 32 , apolipoprotein D claim 32 , beta-lactoglobulin claim 32 , complement component C8 gamma chain claim 32 , crustacyanin claim 32 , epididymal-retinoic acid binding protein (E-RABP) claim 32 , insectacyanin claim 32 , odorant binding protein (OBP) claim 32 , human pregnancy-associated endometrial alpha-2 globulin (PAEP) claim 32 , probasin (PB) claim 32 , a prostatic protein claim 32 , prostaglandin D synthase claim 32 , purpurin claim 32 , Von Ebner's gland protein (VEGP) claim 32 , and lizard epididymal secretory protein IV (LESP IV).34. The method of claim 32 , where the at least one protein from the lipocalin family is selected from the group ...

Hemodialysis system including a disposable cassette

A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.

DIALYSATE-EXTRACTING APPARATUS

A dialysate-extracting apparatus in which a collecting port can be disinfected with no disinfecting work to be performed by a worker. A dialysate-extracting apparatus includes a dialysate-extracting device having an introduction port and a discharge port each of which is connected to the flow route for liquid and allows the liquid to flow therethrough, and a collecting port from which the liquid flowing in the flow route is collectable; and an opening-and-closing device that is movable between a closing position where the opening-and-closing device covers the collecting port of the dialysate-extracting device and an opening position where the opening-and-closing device opens the collecting port. The dialysate-extracting apparatus further includes an ultraviolet-applying device attached to the opening-and-closing device and that is capable of applying ultraviolet rays to the collecting port when the opening-and-closing device is at the closing position. 1. A dialysate-extracting apparatus comprising:a dialysate-extracting device having an introduction port and a discharge port each of which is connected to a flow route for liquid and allows the liquid to flow therethrough, and a collecting port from which the liquid flowing in the flow route is collectable; andan opening-and-closing device that is movable between a closing position where the opening-and-closing device covers the collecting port of the dialysate-extracting device and an opening position where the opening-and-closing device opens the collecting port,wherein the dialysate-extracting apparatus further comprises an ultraviolet-applying device attached to the opening-and-closing device and that is capable of applying ultraviolet rays to the collecting port when the opening-and-closing device is at the closing position.2. The dialysate-extracting apparatus according to claim 1 , further comprising:a sealing unit that seals the collecting port,wherein the ultraviolet-applying device is capable of applying ...

METHOD FOR DETERMINING AT LEAST ONE PARAMETER OF AN EXTRACORPOREAL BLOOD CIRCUIT AS WELL AS APPARATUSES

A method for determining at least one parameter of an extracorporeal blood circuit includes the steps of filling an extracorporeal blood circuit, e.g., encompassing a medical functional device, a treatment device and/or a blood tube set, by introducing a fluid, and detecting a volume of the introduced fluid which is required for filling the extracorporeal blood circuit by a detection device. A control device, a treatment apparatus, a computer readable storage medium, a computer program product as well as a computer program are also described. 1. A method for determining at least one parameter of an extracorporeal blood circuit or a component thereof , comprising:filling the extracorporeal blood circuit by introducing a fluid; andone of detecting, determining and calculating a size of a volume of the introduced fluid which is required for filling at least one of the extracorporeal blood circuit and a predetermined section thereof.2. The method according to claim 1 , wherein the filling serves as a preparation of the extracorporeal blood circuit.3. The method according to claim 1 , further comprising:processing a value of the detected fluid volume for maintaining the at least one parameter.4. The method according to claim 1 , wherein the volume of the fluid is a cumulative volume.5. The method according to claim 1 , further comprising:conveying the fluid through the at least one of the extracorporeal blood circuit and the predetermined section thereof by a blood pump having at least one of a constant and a predetermined flow;determining a point in time when the fluid appears at a first sensor of the extracorporeal blood circuit as a first point in time;determining a point in time when the fluid appears at a second sensor of the extracorporeal blood circuit as a second point in time;determining a time difference between the first point in time and the second point in time;wherein the one of detecting, determining and calculating of the size of the volume of the ...

BLOOD PURIFICATION APPARATUS

A blood purification apparatus includes a blood circuit through which blood of a patient extracorporeally circulate, and a dialyzer that purifies the blood flowing in the blood circuit. The apparatus includes a pressure-change-producing device capable of applying a positive pressure or a negative pressure to distal portions of the blood circuit while an arterial puncture needle (a) and a venous puncture needle (b) are yet to be connected to the blood circuit, a pressure-change-detecting device capable of detecting pressure changes in the distal portions of the blood circuit that occur when the distal portions of the blood circuit that are under the positive pressure or the negative pressure applied by the pressure-change-producing device are connected to the arterial puncture needle (a) and the venous puncture needle (b) that are stuck in the patient, and an evaluation device capable of evaluating a state of sticking of the arterial puncture needle (a) and the venous puncture needle (b) on the basis of the pressure changes detected by the pressure-change-detecting device. 1: A blood purification apparatus comprising:a blood circuit having a distal end and a puncture needle connectable to the distal end, blood of a patient being extracorporeally circulated through the blood circuit and the puncture needle; anda blood purification device that purifies the blood flowing in the blood circuit,the blood purification apparatus being capable of performing blood purification treatment through the blood purification device while extracorporeally circulating the blood of the patient through the blood circuit with the puncture needle being stuck in an access vessel of the patient,a pressure-change-producing device capable of applying a positive pressure or a negative pressure to a distal portion of the blood circuit while the puncture needle is yet to be connected to the blood circuit;a pressure-change-detecting device capable of detecting a pressure change in the distal ...

BLOOD PURIFICATION DEVICE

A blood purification device is provided with: a blood circuit for extracorporeally circulating blood of a patient; a blood purifier provided in the blood circuit ; a gas-liquid separator which is provided in the blood circuit and located on the downward side of the blood purifier in the direction of blood flow, and separates air bubbles contained in blood flowing thereinto; and a liquid surface adjustment unit capable of adjusting the liquid level in the gas-liquid separator . The liquid surface adjustment unit performs control such that the liquid level during priming is higher than the liquid level during treatment. 1. A blood purification device , comprising:a blood circuit for extracorporeally circulating blood of a patient;a blood purifier provided on the blood circuit;a gas-liquid separator being provided on the blood circuit on the downstream side of the blood purifier on a blood flow and separating air bubbles contained in inflowing blood; anda liquid level adjustment unit capable of adjusting a liquid level height in the gas-liquid separator,wherein the liquid level adjustment unit performs control so that the liquid level height during priming is higher than the liquid level height during treatment.2. The blood purification device according to claim 1 , wherein the liquid level adjustment unit comprises a first liquid level detection sensor being provided at a first height position of the gas-liquid separator and being capable of detecting whether a gas is present at the first height position inside the gas-liquid separator claim 1 , a liquid level adjustment mechanism capable that can adjust the liquid level height by introducing air into the gas-liquid separator or discharging air from the gas-liquid separator claim 1 , and a liquid level control unit controlling the liquid level adjustment mechanism so that claim 1 , during treatment claim 1 , the gas is detected at the first height position and the liquid level height is lower than the first height ...

INFUSION TUBE ASSEMBLY, INFUSION DEVICE, AND INFUSION METHOD

An infusion device includes an infusion pump and an infusion tube assembly. The infusion tube assembly includes a first tube body connected to the infusion pump, a tube joint structure having first, second and third tube joints, a second tube body, and a clamping device on the second tube body. The clamping device is to clamp the second tube body. An infusion method includes instructing the infusion pump to perform an infusion operation. When bubbles are detected in a liquid in the infusion tube assembly, the infusion pump is instructed to stop the infusion operation and a bubble alarm is generated. After the infusion pump stops the infusion operation, it is determined whether a pressure of the liquid first drops to a first pressure value and then rises to a second pressure value. If yes, a rinsing operation is performed. 1. An infusion tube assembly applied to an infusion pump , the infusion tube assembly comprising:a first tube body configured to be connected to the infusion pump;a tube joint structure having a first tube joint, a second tube joint, and a third tube joint, wherein the first tube joint is connected to one end of the first tube body;a second tube body, wherein one end of the second tube body is connected to the second tube joint; anda clamping device disposed on the second tube body and configured to clamp the second tube body.2. The infusion tube assembly of claim 1 , further comprising:a liquid container engaged to the third tube joint.3. The infusion tube assembly of claim 1 , wherein the tube joint structure is Y-shaped.4. The infusion tube assembly of claim 1 , wherein an angle between the first tube joint and the third tube joint is an acute angle.5. The infusion tube assembly of claim 1 , wherein an angle between the first tube joint and the second tube joint is an obtuse angle.6. An infusion device claim 1 , comprising:an infusion pump;a first tube body configured to be connected to the infusion pump;a tube joint structure having a first ...

Blood Purification Apparatus and Method of Estimating Patient's State of Nutrition On Blood Purification Apparatus

A blood purification apparatus that accurately calculates the colloid osmotic pressure of a patient's blood. A dialyzer included in the blood purification apparatus has thereinside blood flow routes and dialysate flow routes that are separated from each other by hollow fibers. An ultrafiltration pump draws out water from the blood in the blood flow routes through the hollow fibers into the dialysate flow routes. Four detecting units measure the pressures of liquid flowing into the blood flow routes, the liquid discharged from the blood flow routes, dialysate flowing into the dialysate flow routes, and the dialysate discharged from the dialysate flow routes. The pressures at the four positions, the transmembrane pressure difference can be calculated. The blood flow routes are filled with a priming solution, and the transmembrane pressure difference (TMPa) is measured. Subsequently, the blood flow routes are filled with the patient's blood, and the transmembrane pressure difference (TMPb) is measured. Referencing TMPa and TMPb, the colloid osmotic pressure of the patient's blood can be calculated. Referencing colloid osmotic pressure, the plasma total protein can be calculated. Referencing plasma total protein, the patient's state of nutrition can be estimated. 1. A blood purification apparatus that includesa blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;a blood purifier provided between the arterial blood circuit and the venous blood circuit and that purifies the blood flowing through the blood circuit, the blood purifier having a blood flow route through which the blood extracorporeally circulating through the blood circuit flows and a dialysate flow route through which dialysate flows, the blood flow route and the dialysate flow route being separated from each other by a blood ...

PERITONEAL DIALYSIS MACHINE

A method for operating a dialysis cassette including a flexible membrane that covers a pump chamber includes allowing a source of fluid to fluidly communicate with the pump chamber of the dialysis cassette, filling the pump chamber with the fluid from the source, mechanically extending the flexible membrane into the pump chamber with a piston head to expel the fluid from the pump chamber through a flow path, and directly sensing a pressure of the fluid flowing through the flow path at a location of the dialysis cassette adjacent to the pump chamber and using the sensed pressure to perform a test prior to delivering fluid to a patient. 1. A method for operating a dialysis cassette including a flexible membrane that covers a pump chamber , the method comprising:allowing a source of fluid to fluidly communicate with the pump chamber of the dialysis cassette;filling the pump chamber with the fluid from the source;mechanically extending the flexible membrane into the pump chamber with a piston head to expel the fluid from the pump chamber through a flow path; anddirectly sensing a pressure of the fluid flowing through the flow path at a location of the dialysis cassette adjacent to the pump chamber and using the sensed pressure to perform a test prior to delivering fluid to a patient.2. The dialysis cassette operating method of claim 1 , wherein the test includes determining that a line occlusion has occurred based on the sensed pressure.3. The dialysis cassette operating method of claim 1 , which includes pulling a vacuum on the flexible membrane claim 1 , opening the membrane within the pump chamber to fill the pump chamber with the fluid.4. The dialysis cassette operating method of claim 1 , wherein directly sensing the pressure includes directly sensing the pressure of the fluid flowing through the flow path at a location of the dialysis cassette between the pump chamber and a valve actuation position of the flow path.5. The dialysis cassette operating method of ...

Blood Purification Apparatus

A blood purification apparatus has a blood circuit with an arterial blood circuit ( 1 ) and a venous blood circuit ( 2 ). Blood is extracorporeally circulated from a tip of the arterial blood circuit ( 1 ) to a tip of the venous blood circuit ( 2 ). A dialyzer ( 3 ) is interposed between the arterial blood circuit ( 1 ) and the venous blood circuit ( 2 ) to purify the blood. The blood purification apparatus can substitute the blood inside the blood circuit during returning of the blood after treatment. An air circulation line is connected to a predetermined portion in the blood circuit to circulate air. An air pump ( 18 ) supplies the air into the blood circuit, via the air circulation line. A control device ( 19 ) controls the air pump ( 18 ) to supply the air into the blood circuit during returning of the blood.

Blood Component Separation Device

A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor, and collecting platelets, includes: an operation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, wherein the operating unit sets the predicted platelet recovery rate calculated from any the hematocrit value and any the platelet concentration to be smaller by a predetermined value a when the blood donor is female than that when the blood donor is male. 1. A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor , and collecting platelets , comprising:an operation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, whereinthe operating unit sets the predicted platelet recovery rate calculated from the hematocrit value and the platelet concentration to be smaller by a predetermined value when the blood donor is female than that when the blood donor is male.2. The blood component separation device according to claim 1 , whereinthe predetermined value increases as the recommended processing amount of the blood increases.3. The blood component separation device according to claim 1 , whereina) a centrifugal separation step of introducing the blood into a centrifuge, and separating the blood into a plurality of blood components;b) a circulation flow step of introducing plasma among the separated blood components into the centrifuge together with the ...

HEMODIALYSIS SYSTEMS AND METHODS

The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second ...

HEMODIALYSIS SYSTEMS AND METHODS

Hemodialysis systems are described. A hemodialysis system may include a dialysate flow path through which dialysate is passed from a dialysate reservoir, which includes a valved vent to atmosphere, to an ultrafilter. The dialysate flow path includes a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter. The hemodialysis system may include a controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere. The hemodialysis system may be configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain. 1142.-. (canceled)143. A hemodialysis system comprising:a dialysate flow path through which dialysate is passed from a dialysate reservoir to an ultrafilter;the dialysate flow path comprising a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter;the dialysate reservoir including a valved vent to atmosphere; anda controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere;wherein the hemodialysis system is configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain.144. The hemodialysis system of claim 143 , wherein the dialysate pump comprises a pneumatic actuation chamber separated from a pumping chamber by a flexible diaphragm claim 143 , the pneumatic actuation chamber in communication with a pressure sensor claim 143 , and wherein pressure data from the pressure sensor is monitored by the controller while air is pumped by the dialysate pump from the dialysate reservoir to the ultrafilter.145. The hemodialysis ...

DUAL LUMEN CANNULA AND METHOD OF USE

The present invention is directed to a dual lumen cannula configured to be inserted into a patient's body as simple as a single lumen cannula. The dual lumen cannula includes at least one inner lumen configured to be inserted into an outer lumen and connected via an inner lumen connection unit and an outer unit connection unit. Embodiments of the presenting invention further allow for the connection of at least one flow router to the other end of the inner lumen connection unit. When installed, the outer lumen is first inserted into the patient's body, followed by the insertion of the inner lumen into the outer lumen of the already cannulated patient until the inner lumen connector unit is in coupling contact with the outer lumen connector unit. Advantages of the inventive cannula presented herein include, among other things, reduction of external forces on the dual lumen cannula. 1. A dual lumen cannula which can be assembled while being introduced in a patients vascular system in real time , in vivo , the cannula comprising:at least one inner lumen having at least two ends, an inner lumen proximate end and an inner lumen distal end, a hollow intermediate extent between said two ends having one or more openings at the inner lumen distal end, and at least one inner lumen connector unit at the inner lumen proximate end;at least one outer lumen having at least two ends, an outer lumen proximate end and an outer lumen distal end, a hollow intermediate extent between said two ends having one or more openings, said intermediate extent further comprising one or more openings at the outer lumen distal end, and at least one outer lumen connector unit at the outer lumen proximate end; andat least one flow router;wherein said inner lumen is configured to be inserted into said outer lumen, in vivo, and after said outer lumen has been installed in a patient, until said inner lumen connector unit is in coupling contact with said outer lumen connector unit;wherein said flow ...

MEDICAL FLUID THERAPY MACHINE INCLUDING SERVICING REGIME THEREFORE

A medical fluid delivery system includes: a medical fluid delivery machine including a component having at least one of associated output data or associated test data; at least one of a (i) component output replacement limit and a component output soft limit for the component or (ii) a component testing replacement limit or a component testing soft limit for the component; and a computer programmed to store at least one of (i) or (ii), and for (i) analyze the output data to provide a first indication of how well the component is performing relative to the component output replacement limit and the component output soft limit, and for (ii) analyze the test data to provide a second indication of how well the at least one component is testing relative to the component testing replacement limit and the component testing soft limit. 1. A medical fluid delivery system comprising:a medical fluid delivery machine including at least one component producing associated output data;at least one component replacement limit for the at least one component; anda computer programmed to store the at least one component replacement limit and to analyze the output data to provide an indication of how well the at least one component is performing relative to its component replacement limit.2. The medical fluid delivery system of claim 1 , wherein the medical fluid delivery machine includes a display device claim 1 , the computer provided by a control unit of the medical fluid delivery machine claim 1 , and wherein the indication is displayed by the display device of the medical fluid delivery machine.3. The medical fluid delivery system of claim 1 , wherein the computer is a remote computer having a display device claim 1 , the medical fluid delivery machine in data communication with the remote computer via at least one server claim 1 , and wherein the indication is displayed by the display device of the remote computer.4. The medical fluid delivery system of claim 1 , wherein the ...

FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES

A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session. 1. A portable dialysis cabinet , comprising:a dialysis system;at least two wheels disposed on a bottom surface of the dialysis cabinet;a first pair of opposing doors hingeably disposed on the dialysis cabinet creating when said doors are closed a first and second interior portions of the dialysis cabinet, the first pair of opposing doors having a first door connected to the dialysis cabinet by a first hinge on a front left side of the dialysis cabinet and a second door connected to the dialysis cabinet by a second hinge on a front right side of the dialysis cabinet, wherein the first door opens by swinging about a first vertical axis defined by a the first hinge on the left side of the dialysis cabinet and the second door opens by swinging about a second vertical axis defined by the second hinge on front right side of the dialysis cabinet; wherein the first door and second door are in contact when the first door and second door are closed; wherein the first and second interior portions are occupied by one or more interior components when closed; andat least one mounting surface for mounting a sorbent cartridge on a base of at least one of the first and second doors.2. The portable dialysis cabinet of claim 1 , further comprising at least a second mounting surface for mounting a reservoir on at least one of the first and second doors.3. The portable dialysis cabinet of claim 1 , wherein the first pair of opposing doors in an opened configuration provide access to one or more fluid connection ports located on a main body of the base ...

SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL

Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end. 1. A system for performing any one of hemodialysis , hemodiafiltration , hemofiltration , comprising:a controlled compliant flow path comprising a dialyzer;at least a first pump in fluid communication with the controlled compliant flow path; a common reservoir in fluid communication with the first pump, wherein the common reservoir contains any one of a dialysate, a filtrate, a volume of a physiologically compatible priming solution, a volume of a physiologically compatible solution to provide a bolus of fluid to a subject receiving treatment, a volume of physiologically compatible solution to provide solution for return of blood from an extracorporeal flow path to a subject receiving treatment, a volume of solution returned to the common reservoir from an extracorporeal flow path when blood from a subject is introduced to the extracorporeal flow path, and combinations thereof;the at least first pump for selectively metering in and/or metering out fluid from the controlled compliant flow path; andthe at least first pump operable to control net fluid movement into and/or out of the controlled compliant flow path, wherein the at least first pump is operated by a controller applying an instantaneous rate of fluid removal to a control algorithm.2. The system of claim Error! Reference source not found. , wherein the controller applies the control algorithm to obtain a net volume of fluid added to and/or removed from a patient during therapy by an equation:{'br': None, 'sub': i=0', 'i, 'sup': 'n', 'i ...

SYSTEMS AND METHODS FOR OPTIMIZATION OF PLASMA COLLECTION VOLUMES

A system for collecting plasma comprises a separator to separate whole blood from a donor into a plasma product and a second blood component, an anticoagulant line to combine anticoagulant with the whole blood, a touchscreen, and a controller. The controller is configured to receive donor parameters electronically from a donor management system. The controller is configured to use a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The controller is configured to control the system to operate draw and return phases to withdraw whole blood from a donor and return the second blood component to the donor until a volume of raw plasma in the collection container equals the target volume of raw plasma. 1. A system for collecting plasma , comprising:a separator configured to separate whole blood into a plasma product and a second blood component comprising red blood cells, the separator having a plasma output port coupled to a plasma line configured to send the plasma product to a plasma product collection container;a donor line configured to introduce the whole blood from a donor to the separator;an anticoagulant line coupled to an anticoagulant source configured to combine anticoagulant with the whole blood from the donor based on an anticoagulant ratio (ACR);a touchscreen configured to receive input from an operator; and{'sub': RP', 'RP', 'PP, 'a controller configured to control operation of the system, the controller coupled to the touchscreen and configured to receive donor parameters electronically from a donor management system, to use a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume, wherein the target volume for raw plasma is set prior to blood collection from ...

System and Method for the Re-Anticoagulation of Platelet Rich Plasma

A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container. 1. A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system , the method comprising:priming the blood apheresis system with anticoagulant such that a volume of anticoagulant is transferred to a PRP collection container;transferring the anticoagulant within the PRP collection container to a second container;collecting a volume of platelet rich plasma within the PRP collection container, the volume of platelet rich plasma being collected in a plurality of cycles;transferring at least a portion of the volume of anticoagulant from the second container to the PRP collection container between each of the plurality of cycles.2. A method according to claim 1 , wherein the at least a portion of the volume of anticoagulant transferred to the PRP collection container is proportional to an amount of platelet rich plasma collected in the preceding cycle.3. A method according to claim 1 , wherein priming the blood apheresis system with anticoagulant includes priming an anticoagulant line and a donor line filter with anticoagulant.4. A method according to claim 3 , wherein priming the blood apheresis system includes transferring the anticoagulant within the donor line filter to the second container.5. A method according to claim 4 , wherein the anticoagulant within the donor line filter is transferred to the second container at the start of the ...

FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES

A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session. 1. A portable dialysis cabinet , comprising:a dialysis system; andat least two wheels disposed on a bottom surface of the dialysis cabinet.2. The portable dialysis cabinet of claim 1 , further comprising a handle disposed on the exterior portion of the dialysis cabinet.3. The portable dialysis cabinet of claim 2 , wherein the handle is a telescoping handle.4. The portable dialysis cabinet of claim 1 , further comprising at least one door hingeably disposed on the dialysis cabinet creating an interior portion of the dialysis cabinet and an exterior portion of the dialysis cabinet.5. The portable dialysis cabinet of claim 4 , wherein the at least one door comprises at least one shelf claim 4 , and the dialysis cabinet further comprises a user interface module attached to the dialysis cabinet and in electronic communication with a control module.6. The portable dialysis cabinet of claim 5 , wherein the user interface comprises one or more of a keyboard claim 5 , a touch screen claim 5 , a display screen claim 5 , a mouse claim 5 , a microphone claim 5 , and a speaker.7. The portable dialysis cabinet of claim 5 , wherein the user interface is a stowable user interface claim 5 , and wherein the dialysis cabinet comprises a recess into which the user interface can be stowed.8. The portable dialysis cabinet of claim 1 , further comprising one or more fluid connection ports on the interior portion of the dialysis cabinet.9. The portable dialysis cabinet of wherein the shelf comprises at least one mounting surface.10. The portable dialysis ...

Priming System and Method for Dialysis Systems

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. 1. A priming process for priming a manifold within a dialysis machine for use in a dialysis treatment , comprising the steps of:a. Inserting said manifold into the dialysis machine, wherein said manifold comprises a substrate defining a first circuit and a second circuit and a compressible valve structure in fluid communication with each of said first and second circuits, wherein said valve structure has a first state and a second state and wherein, when in said first state, fluid from the first circuit cannot enter into the second circuit and when in said second state, fluid from the first circuit can enter into the second circuit;b. Placing said valve in said second state by removing pressure from said compressible valve structure;c. Pumping fluid through said first and second circuits;d. Placing said valve in said first state by applying pressure to said compressible valve structure; ande. Removing fluid from said second circuit.2. The priming process of wherein the first circuit is a dialysate circuit and wherein the second circuit is a blood circuit.3. The priming process of wherein the fluid is dialysate and wherein claim 2 , in said second state claim 2 , the dialysate flows through the dialysate circuit and into the blood circuit.4. The priming process of wherein the dialysate is removed from the blood circuit upon completion of the priming process.5. The priming process of wherein the dialysate is pumped from a dialysate reservoir and not from a separate ...

Blood Treatment Device Priming Devices, Methods, and Systems

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized. 1. A blood treatment device priming set , comprising:a first circuit part having a first tubular channel element with one or more bag spikes or luer connectors at one end and a blood treatment device blood port connector at a second opposite end;a second circuit part having a second tubular channel element with a drain bag connector at one end and a blood treatment device blood port connector at a second opposite end;the blood treatment device connectors being shaped and sized for connection to venous and arterial ports of a predefined blood treatment device;a drain bag with a drain connector shaped and sized to fit said drain bag connector;the first and second tubular channel elements each having, therealong, a pair of connectors that mate to form a continuous flow path along a respective one of the first and second tubular channel elements,one of each pair being shaped and sized to fit connectors of a predefined blood circuit portion of a blood treatment fluid circuit used for extracorporeal blood treatment;a vent connection component that attaches to a port open to a non-blood compartment of the blood treatment device.2. The set of claim 1 , wherein each pair of connectors includes self-sealing valves that automatically close a fluid path upon disconnection and open the fluid path upon connection.3. The set of claim 2 , wherein each pair of connectors is connected to a removable interconnect member that ...

MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS

A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed. 154.-. (canceled)55. A disposable fluid circuit configured to interface with a hardware component to form an automated blood collection system for collecting red blood cells and plasma from a donor comprising , the disposable component comprising:a donor access device for withdrawing whole blood from a donor;a whole blood collection container in communication with the donor access device;a blood separation device communicating with the whole blood collection container and employing relatively rotating surfaces, at least one of which carries a membrane substantially permeable to plasma and substantially impermeable to red blood cells to separate the whole blood into substantially concentrated red cells and plasma;a first collection container communicating with the blood separation device for receipt of the substantially concentrated red blood cells;a source of preservative solution communicating with the first collection container; anda second collection container communicating with the blood separation chamber for receipt of the ...

Filling device of a fluid system

Disclosed is a filling device of a fluid conducting system of an extracorporeal blood treatment device that includes a spike for connecting to the single fluid connector of a medical fluid container and a manually operable fluid blocking mechanism arranged directly downstream of the spike that fluidly connects with the spike while the filling device is in operation. The fluid blocking mechanism has at least one fluid outlet connector that is adapted so that a line section or hose of the fluid conducting system such as the arterial line section of a blood purification device can be connected to it in a detachable manner while the filling device is in operation.

APPARATUS AND METHOD TO CHECK EXTRACORPOREAL CIRCUIT

An extracorporeal treatment assembly including a pump and a controller wherein an extracorporeal circuit is mounted to the assembly, the controller causes the assembly to: control the pump to pump liquid through the passage and the flow coupling; collect actual fluid pressure data; store circuit type data uniquely corresponding to a certain type of extracorporeal circuit; determine a dimension of the certain type of extracorporeal circuit; determine an expected fluid pressure for the certain type of extracorporeal circuit; based on a comparison of the actual fluid pressure data and the expected fluid pressure, determine whether the certain type of extracorporeal circuit corresponds to the actual extracorporeal circuit. 157.-. (canceled)58. An extracorporeal treatment apparatus configured to receive an extracorporeal circuit , the treatment apparatus comprising a pump configured to pump a liquid through a passage in the extracorporeal circuit while the circuit is mounted to the treatment apparatus;a flow coupling connectable to an outlet of the passage, the flow impedance at the flow coupling is a constant or known value; anda controller which is configured to:store a flow resistance value at the flow coupling, said flow resistance value being either a value set by the operator before starting apparatus or a pre-stored constant value known by the controller before starting the apparatus;control the pump at a speed corresponding to a set fluid flow value to move liquid through the passage, and the flow coupling;collect actual data indicative of a pressure condition of the liquid flowing through the passage and flow coupling during control of the pump at said speed;store a data uniquely corresponding to an expected circuit type mounted to the treatment apparatus out of a plurality extracorporeal circuit types that may be mounted to the treatment apparatus, optionally said data being acquired by the apparatus or set by the operator before starting the operation of the ...

Methods and Systems for Maintaining Patient Fluid Balance During an Extracorporeal Therapeutic Cell Treatment

Methods and systems for maintaining patient fluid balance during an extracorporeal cell treatment are disclosed. The method includes minimizing the amount of saline or other fluid that is returned to the donor. Saline used during priming of the fluid circuit may be used to increase the volume of the collected cells to arrive at a treatment-ready product with a suitable hematocrit. 1. A method for maintaining fluid balance in a patient undergoing a therapeutic cellular treatment comprising:a) priming a fluid flow path of a disposable fluid circuit mounted on a reusable hardware unit with a predetermined volume of a priming solution;b) diverting at least a portion of said predetermined volume of said priming solution from the flow path of the fluid circuit;c) collecting target cell population from a patient in fluid communication with said fluid circuit;d) combining said at least a portion of said diverted priming solution with said target cell population to arrive at a treatment-ready product;e) treating the treatment-ready product to arrive at a treated cellular product; andf) administering the treated cellular product to said patient.2. The method of wherein said priming solution comprises saline.3. The method of further comprising combining a treating agent with said target cell population.4. The method of wherein said target cell population comprises mononuclear cells.5. The method of wherein said hardware unit comprises a centrifuge and said disposable fluid circuit comprises a separation chamber mounted on said centrifuge claim 1 , said method further comprising introducing whole blood from said patient into said separation chamber claim 1 , spinning said centrifuge to cause said whole blood to separate into blood components and removing said priming solution from said separation chamber.6. The method of comprising rotating said centrifuge to maintain an interface between said priming solution and a blood component.7. The method of comprising detecting a ...

CARDIOPULMONARY APPARATUS AND METHODS FOR PRESERVING LIFE

Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include seven-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure comprising repairing or replacing the heart valve in a patient. 113.-. (canceled)14. A method for performing transvascular heart valve repair or replacement in a patient comprising the steps of: a) priming a heart-lung machine with a priming liquid in a priming mode; b) switching the heart lung machine from the priming mode to an operational mode; c) connecting a venous blood inlet on the heart lung machine to a vein in the patient and connecting an arterial blood outlet from the heart lung machine to an artery in the patient to form a closed extracorporeal blood circulation in fluid contact with the patient circulatory system; d) operating the heart-lung machine in said operational mode to take venous blood from the patient , oxygenate the venous blood , and return oxygenated blood to the patient; and e) repairing or replacing the heart valve in said patient wherein: said heart-lung machine comprises a blood reservoir , a blood pump , an air extraction pump , an oxygenator , and a blood filter; the air extraction pump is in fluid communication with an air space at the top of the blood reservoir and configured to pump air from the blood reservoir; the blood pump is in fluid communication with and downstream from a blood space at the bottom of the blood reservoir and in fluid communication with and upstream from the oxygenator; the blood filter is in fluid communication with and downstream from the oxygenator; and separate event lines connect the top most spaces within each of the oxygenator and the blood filter with the blood reservoir.15. The method of claim 14 , wherein said blood reservoir is separated into a lower blood-containing space and an upper air-containing space by a membrane that is permeable to blood but not to air bubbles. ...

CALIBRATION METHOD FOR FLOWMETERS IN BLOOD DIALYSIS SYSTEM

Provided is a calibration method for flowmeters in a blood dialysis system, whereby highly accurate calibration can be performed even by omitting a reference flowmeter not directly relating to dialysis therapy. This calibration method comprises: while preventing outflow into a blood channel in a blood purifier, supplying a liquid to a channel, said channel passing through an inflow flowmeter and an outflow flowmeter; and then calibrating the inflow flowmeter and the outflow flowmeter correction whereby, at the time of liquid supply, a value measured by the outflow flowmeter is equalized to a value measured by inflow flowmeter. 1. A calibration method for flowmeters in a blood dialysis system , the blood dialysis system comprising:a blood purifier comprising a dialysis membrane, dialysate and blood being supplied to the blood purifier to undergo substance exchange therebetween, via the dialysis membrane;a liquid feeding pump configured to supply the dialysate to the blood purifier;a liquid discharging pump configured to discharge the dialysate from the blood purifier;an inflow flowmeter configured to measure a quantity of flow of the dialysate to be supplied to the blood purifier;an outflow flowmeter configured to measure a quantity of flow of the dialysate to be discharged from the blood purifier; anda calculation unit configured to measure a quantity of fluid removal from the blood based on a difference in measurements between the inflow flowmeter and the outflow flowmeter,the calibration method comprising:supplying liquid to a flow channel passing through the inflow flowmeter and the outflow flowmeter while preventing outflow of the liquid to a blood flow channel in the blood purifier; andperforming correction to match the measurements of the outflow flowmeter obtained when the liquid is supplied with the measurements of the inflow flowmeter, thereby calibrating the inflow flowmeter and the outflow flowmeter.2. A calibration method for flowmeters in a blood ...

Systems and Methods for Removing Undesirable Material Within a Circulatory System

The present invention relates generally to improved systems and methods for removing undesirable material residing in vessels. More specifically, the present invention relates to systems and methods for using at least one cannula to remove to remove substantially en bloc, from a site of obstruction or interest, undesirable material without fragmentation and without excessive fluid loss. 1. A system for removing undesirable material from within a vessel , the system comprising: a proximal end;', 'a distal end;', 'a shaft comprising an inner layer, a reinforcement element, and an outer layer, and', 'an expandable distal end formed in part by extensions of the outer layer of the shaft, the expandable distal end further comprising reinforcement arms on top of the outer layer extensions, the expandable distal end further comprising a jacket between the outer layer extensions, and the expandable distal end capable of expanding to a diameter greater than the proximal end and capturing the undesirable material from the vessel;, 'a first cannula, the first cannula comprisinga second cannula, the second cannula having a proximal end and a distal end, the distal end of the second cannula is placed in a spaced relation to the distal end of the first cannula;a pump, the pump being in fluid communication with the proximal of the first cannula and the proximal end of the second cannula; anda filter, the filter placed in fluid communication with the proximal end of the first cannula.2. The system of claim 1 , further comprising an outer sheath claim 1 , the outer sheath capable of being advanced towards the distal end of the first cannula or retracted towards the proximal end of the second cannula.3. The system of claim 1 , wherein the reinforcement element comprises a flat coil allowing for a greater increased luminal diameter claim 1 , as compared to a round wire.4. The system of claim 1 , wherein the expandable distal end of the first cannula further comprises a proximal collar ...

SYSTEMS AND METHODS FOR OPTIMIZATION OF PLASMA COLLECTION VOLUMES

A system for collecting plasma comprises a separator to separate whole blood from a donor into a plasma product and red blood cells, an anticoagulant line to introduce anticoagulant to the whole blood, a touchscreen, and a controller. The controller is configured to receive donor parameters electronically from a donor management system. The controller is configured to use a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller is configured to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor. 2. The system of claim 1 , wherein the target volume for plasma product and/or raw plasma is set prior to blood collection from the donor.3. The system of claim 1 , wherein the controller is further configured to operate the draw and return phases until a volume of raw plasma (V) in the collection container equals the target volume of raw plasma claim 1 , the volume of raw plasma (V) based on a measured volume of plasma product (V).4. The system of claim 1 , wherein ACR=Volume of Whole Blood/Volume of Anticoagulant.5. The system of claim 3 , wherein the volume of plasma product (V) is measured by a weigh scale.6. The system of claim 5 , wherein the controller is configured to calculate the volume of raw plasma (V) in the collection container based on a measured volume of plasma product (V) claim 5 , the ACR and a hematocrit of the donor7. The system of claim 1 , wherein the controller is configured to receive the donor's weight and hematocrit electronically from the donor management system claim 1 , wherein the donor management system is used for qualification screening.8. The system of claim 7 , ...

BLOOD PURIFICATION APPARATUS AND PRIMING METHOD FOR THE SAME

The present teachings provide a blood purification apparatus and a priming method, which can reduce or dispense with dedicated components used for automated priming and which can reduce manufacturing costs of a blood circuit while achieving the automated priming. The present teachings further provide a blood purification apparatus including a liquid level adjustment device that can optionally introduce or discharge air into or from an upper portion of a venous air trap chamber, a control device that can adjust a liquid level formed inside the venous air trap chamber to have the height at any desired position by operating the liquid level adjustment device, and a priming solution supplying line that can supply a priming solution to an arterial blood circuit and a venous blood circuit. As taught herein, during priming, the control device can fill the arterial blood circuit and the venous blood circuit with priming solution supplied from the priming solution supplying line by operating the liquid level adjustment device at any desired timing. 1. A blood purification apparatus comprising: an arterial blood circuit and', 'a venous blood circuit, wherein the blood circuit extracorporeally circulates blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;, 'a blood circuit that includesa blood purification device that is interposed between the arterial blood circuit and the venous blood circuit in the blood circuit, and that can purify the blood flowing in the blood circuit;a blood pump that is arranged in the arterial blood circuit;a venous air trap chamber that is connected to the venous blood circuit;a liquid level adjustment device that is connected to the venous air trap chamber, and that can optionally introduce or discharge air into or from an upper portion of the venous air trap chamber;a control device that can adjust a liquid level formed inside the venous air trap chamber to have the height at any desired ...

Venting system with a venting unit and a venting device set and method of operating a venting system

A deaerating device set allows a priming circuit to be deaerated fully automatically using a deaerating unit and a priming control unit, a priming liquid container and preferably a priming pump or a priming compressor. A blood pump is operated in a pulsatile manner during the pumping of a priming fluid.

DEVICES, METHODS, AND SYSTEMS FOR PRIMING, SEPARATING, AND COLLECTING BLOOD COMPONENTS

A photopheresis system () is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols () for purging air out of a centrifuge bowl () used by the photopheresis system (); 2) protocols () for assessing the installation/operation of one or more pressure domes () used by the photopheresis system (); and 3) protocols () for collecting buffy coat from blood processed by the photopheresis system (). 1. A method of operating a blood processing system , wherein said blood processing system comprises a deck and a disposable kit , wherein said deck comprises a pressure transducer , wherein at least part of said kit is installed on said deck , wherein said at least part of said kit comprises a pressure dome positioned on said pressure transducer , and wherein said pressure dome comprises a flow chamber , a first flow port for said flow chamber , and a second flow port for said flow chamber , said method comprising:executing a first negative pressure test on said pressure dome and comprising attempting to generate a first vacuum within said flow chamber by withdrawing fluid out of said flow chamber through one of said first and second flow ports;executing a first positive pressure test on said pressure dome comprising attempting to generate a first positive pressure within said flow chamber by directing fluid into said flow chamber through one of said first and second flow ports, wherein said first positive pressure test is executed after said first negative pressure test; andexecuting a second negative pressure test on said pressure dome comprising attempting to generate a second vacuum within said flow chamber by withdrawing fluid out of said flow chamber through one of said first and second flow ports, wherein said second negative pressure test is executed after said first negative pressure test, and wherein said second vacuum is larger than said first vacuum; andwherein said first negative pressure test, said first ...

Method for filling and rinsing a set of blood lines

A method for the filling and flushing of a blood tube set including a pump segment for a blood pump, an arterial line connected to an inlet of a dialyser, a venous line connected to an outlet of a dialyser, a substituate line connected to a substitute port and having a pump segment for a substitute pump, and a three-way connector connected to the arterial line, the venous line and a rinse port. The method includes the steps of opening the rinse port, filling and simultaneously flushing the arterial and venous lines with the substituate supplied from the substitute line via the substitute pump, while substituate is drained off via the rinse port, closing the rinse port, and circulating the substituate in the circuit of arterial line, dialyser and venous line by the blood pump.

Method and control apparatus for determining and adjusting a flow rate of a blood delivery pump

Flow rate of a blood delivery pump of a blood treatment apparatus is determined and adjusted by connecting a fluid filled container with an extracorporeal blood line of the blood treatment apparatus, performing a priming step to prime the extracorporeal blood line by driving the blood delivery pump at a predetermined theoretical delivery rate to deliver fluid from the filled container into the extracorporeal blood line, determining the loss of fluid of the fluid filled container due to delivery of fluid into the extracorporeal blood line during priming, and determining a correction factor by comparison of a value for an amount of fluid delivered under the theoretical delivery rate with a value for the amount of fluid actually delivered.

BLOOD TREATMENT FILTER DEVICE, PRIMING METHOD, AND BLOOD TREATMENT METHOD

To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter. 17-. (canceled)8. A priming method for a blood treatment filter device having:a body container which has a first port and a second port which are continuous to an internal space and which is disposed with the first port located above the second port in a gravity direction;a blood treatment filter in a dry state placed in the internal space of the body container;a first blood circuit which is connected to the first port and through which liquid flows;a second blood circuit which is connected to the second port and through which liquid flows;a first bypass circuit which is connected to the first blood circuit and the second blood circuit and through which liquid flows; anda second bypass circuit which is connected to a side closer to the first port relative to a connection position of the first bypass circuit in the first blood circuit and is connected to a side further from the second port relative to a connection position of the first bypass circuit in the second blood circuit and through which liquid flows,the priming method comprising:individually closing the circuit between a connection position of the first bypass circuit and a connection position of the second bypass circuit in each of the first blood circuit and the second blood circuit to cause a priming liquid to flow into the internal space of the body container from the first blood circuit through the first bypass circuit, the second blood circuit,and the second port, and then to cause the priming liquid to flow out of the internal space of the body container to the second blood circuit through the first port, the first blood circuit, and the second bypass circuit.9. The priming method for the blood treatment filter device according to claim 8 , whereinthe blood treatment filter has a sheet shape and is placed in the body container in a cylindrically wound state, andthe body container has a liquid flow ...

Methods and systems for priming a biological fluid processing circuit

Methods and systems for priming biological fluid processing systems are disclosed. In accordance with such methods and systems, the disposable fluid processing circuit is primed by introducing a first priming solution into a portion of the circuit and a second priming solution into a portion of the circuit. The amount of citrate returned to the biological flood source is minimized.

BLOOD RINSEBACK SYSTEM AND METHOD

A hemodialysis system is provided and includes a dialyzer, a dialysis fluid circuit in fluid communication with the dialyzer, a blood circuit, a blood detector and a blood rinseback scheme, wherein the blood rinseback scheme includes transferring blood to the patient using a physiologically acceptable fluid, wherein the physiologically acceptable fluid is introduced from its source into an arterial line between an arterial line patient end and a blood pump of the blood circuit, and flowed through the dialyzer, through a venous drip chamber and to the blood detector along a venous line of the blood circuit, where the physiologically acceptable fluid is sensed by the blood detector to indicate an end of the blood rinseback. 1. A hemodialysis system configured to return blood to a patient , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump,', 'a drip chamber located along the venous line;, 'a blood circuit in fluid communication with the dialyzer and including'}a ...

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING MULTIPLE FLUID SOURCES

A hemodialysis system configured to purge air from a blood circuit comprising: a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, and a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged using dialysis fluid or other physiologically acceptable fluid pumped by at least one of the fresh or used dialysis fluid pumps from the dialysis fluid circuit, through the dialyzer, into the blood circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly into the blood circuit. 1. A hemodialysis system configured to purge air from a blood circuit , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication ...

AIR PURGING SYSTEMS FOR BLOOD TREATMENTS

A hemodialysis system configured to purge air from a blood circuit comprises a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump, a drip chamber located along the venous line, and a container for accepting air purged from the blood circuit; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, the blood pump pumps a fluid through the dialyzer and into the drip chamber, forcing air from the drip chamber into the container. 1. A hemodialysis system configured to purge air from a blood circuit , the hemodialysis system comprising:a dialyzer; a fresh dialysis fluid pump,', 'a used dialysis fluid pump,', 'a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and', 'a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;, 'a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including'} an arterial line for removing blood from a patient and delivering the blood to the dialyzer,', 'a venous line for returning blood from the dialyzer to the patient,', 'a blood pump operable with the arterial line upstream of the dialyzer,', 'a physiologically acceptable fluid source in fluid communication with the arterial line ...

Systems and Methods for Removing Undesirable Material Within a Circulatory System

The present invention relates generally to improved systems and methods for removing undesirable material residing in vessels. More specifically, the present invention relates to systems and methods for using at least one cannula to remove substantially en bloc, from a site of obstruction or interest, undesirable material without fragmentation and without excessive fluid loss. 1. A system for removing undesirable material from within a vessel , the system comprising:a cannula comprising a cannula shaft, a cannula expandable distal end, and a reinforcement element comprising at least two reinforcement arms;wherein the cannula shaft comprises a first cannula layer configured to extend from a distal most end of the cannula expandable distal end to a proximal end of the cannula shaft;wherein the first cannula layer is configured to extend between the at least two reinforcement arms; anda pump capable to be connected to the cannula and configured to provide a suction force or a driving force.2. The system of claim 1 , further comprising a second cannula layer.3. The system of claim 1 , wherein the at least two reinforcement arms are configured to pivot between an open position and a closed position.4. The system of claim 1 , wherein the at least two reinforcement arms are made of a shape memory material.5. The system of claim 2 , wherein the reinforcement element further comprises a collar.6. The system of claim 5 , wherein the at least two reinforcement arms are configured to be connected to the collar.7. The system of claim 6 , wherein the collar is configured to abut against a distal most end of the second cannula layer.8. The system of claim 7 , further comprising a third cannula layer; wherein the third cannula layer is configured to be a different material than the first cannula layer and the second cannula layer.9. The system of claim 8 , further comprising a filter; wherein the filter is configured to be in fluid communication with the cannula and the pump.10. ...

SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL

Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end. 1. A system for performing any one of hemodialysis , hemodiafiltration , hemofiltration , comprising:a controlled compliant flow path comprising a dialyzer;at least a first pump in fluid communication with the controlled compliant flow path;a common reservoir in fluid communication with the first pump, wherein the common reservoir contains any one of a dialysate, a filtrate, a volume of a physiologically compatible priming solution, a volume of a physiologically compatible solution to provide a bolus of fluid to a subject receiving treatment, a volume of physiologically compatible solution to provide solution for return of blood from an extracorporeal flow path to a subject receiving treatment, a volume of solution returned to the common reservoir from an extracorporeal flow path when blood from a subject is introduced to the extracorporeal flow path, and combinations thereof;at least a second pump in fluid communication with the controlled compliant flow path and either a fluid source or a reservoir;the first and second pumps for selectively metering in and metering out fluid from the controlled compliant flow path; andthe first pump and second pump operable in concert to control net fluid movement into and out of the controlled compliant flow path.2. The system of claim 1 , wherein the second pump is selected from the group consisting of a water pump claim 1 , an acid concentrate pump claim 1 , a salination pump claim 1 , a replacement fluid pump claim 1 , and combinations thereof.3. The ...

Blood Treatment Device Priming Devices, Methods, and Systems

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized. 1. A method for performing a blood treatment , comprising:flowing blood from a patient through an extracorporeal blood treatment system that uses a replaceable blood treatment device;detecting a condition indicating a need to replace the replaceable blood treatment device;priming a blood treatment device to provide a primed blood treatment device; andreplacing the replaceable blood treatment device with the primed blood treatment device.2. The method of claim 1 , wherein the detecting includes detecting a change in a pressure of a blood circuit.3. The method of claim 2 , wherein the detecting includes detecting a pressure property indicating a rise in pressure drop through the replaceable blood treatment device.4. The method of claim 1 , wherein the flowing includes performing a hemodialysis claim 1 , hemofiltration claim 1 , apheresis claim 1 , or a type of renal replacement therapy treatment.5. The method of claim 1 , wherein the priming includes creating a siphon flow in a priming circuit and automatically halting the siphoning flow prior to an entry of air or other gas or gasses into a fluid circuit of the extracorporeal blood treatment system.6. The method of claim 5 , wherein the automatically halting includes a passive starvation of a flow from a priming source.7. The method of claim 5 , wherein the automatically halting includes a complete filling of a fluid-receiving device until it can hold no ...

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND METHOD OF PRIMING AN EXTRACORPOREAL BLOOD CIRCUIT

An extracorporeal blood treatment apparatus comprises: a blood treatment device (); an extracorporeal blood circuit comprising a blood withdrawal line () and a blood return line () coupled to the extracorporeal blood treatment device (), wherein the blood return line () presents a heating zone () coupled or configured to be coupled to a blood warmer (); a blood pump () configured to be coupled to a pump section of the blood withdrawal line (); at least a post-infusion line () connected to the blood return line () upstream of the heating zone (); an air trapping device () placed on the blood return line () upstream of the heating zone (). 122-. (canceled)23. A method for priming an extracorporeal blood circuit of an extracorporeal blood treatment apparatus , before starting patient treatment , the extracorporeal blood treatment apparatus including: (a) a blood treatment device; and (b) a blood warmer , and the extracorporeal blood circuit including: (i) a blood withdrawal line and a blood return line coupled to the blood treatment device , wherein the blood return line includes a heating zone coupled to the blood warmer; (ii) a blood pump configured to be coupled to a pump section either of the blood withdrawal line or of the blood return line; (iii) at least a post-infusion line connected to the blood return line upstream of the heating zone; and (iv) an air trapping device located along the blood return line upstream of the heating zone , the method comprising:filling the extracorporeal blood circuit of the extracorporeal blood treatment apparatus with a priming fluid, wherein the priming fluid flows at least through the extracorporeal blood treatment device and through at least the blood return line towards the heating zone of said blood return line;diverting, during an initial time interval, the priming fluid into a secondary post-infusion line to bypass a blood warmer operatively active on said heating zone, wherein the secondary post-infusion line is in fluid ...

Medical device with time-controlled start function

A medical device having a time-controlled start function and a control unit, which enables user-friendly operation of the medical device, is described. The medical device has a control unit, which is equipped for automatic start-up of the medical device at a predetermined point in time and for checking on whether, after start-up of the medical device, a predetermined event has occurred, and has a display screen for display of information when the check reveals that the event has not occurred. Furthermore, a corresponding process for user-friendly operation is described.

EXTRACORPOREAL CIRCULATION DEVICE AND CONTROL METHOD

An extracorporeal circulation device having high safety without increases in the circuit scale and the power consumption includes a main control unit responsible for control of a motor drive circuit so as to yield a blood flow rate per unit time set by a user. The motor drive circuit applies a drive signal corresponding to the set blood flow rate to a motor. A sub-control unit configured by a field programmable gate array (FPGA) detects the drive signal applied to the motor and monitors whether or not the drive signal falls within an allowable range corresponding to the set blood flow rate. If the drive signal outside the allowable range is applied, the main control unit is deemed to be in an abnormal state and the main control unit is completely stopped. Then, the sub-control unit takes over the subsequent processing. 1. An extracorporeal circulation device that extracorporeally circulates blood of a subject by using a circulation circuit , the extracorporeal circulation device comprising;a main control unit controlling the extracorporeal circulation device and a sub-control unit comprised of an FPGA (Field-Programmable Gate Array) configured to take over processing relating to extracorporeal circulation in place of the main control unit if the main control unit falls into an abnormal state, a monitoring circuit that monitors a drive signal applied by the main control unit to a motor of a pump for performing the extracorporeal circulation of the blood,', 'a decision circuit that determines whether the main control unit is in a normal state or is in an abnormal state by determining whether or not the drive signal falls within an allowable range for yielding a set amount of fluid sending per unit time during monitoring by the monitoring circuit, and', 'a control circuit that takes over and handles treatment relating to blood circulation in place of the main control unit if it is determined that the main control unit is in an abnormal state by the decision circuit., ' ...

INFUSATE CONTAINERS

The invention relates to infusate containers and related systems and methods for housing infusates that can be added to a fluid flow path for use during dialysis. The infusate containers can include a filter partitioning the containers into a first and second compartment, a draw tube for drawing up fluid from a bottom portion, a cap, a fluid connector for delivery and withdrawal of fluid from the two compartments, and a fluid connector for connection to a dialysis system. 1. An infusate container for use in dialysis , comprising:a container body;a cap removably connected to a top portion of the container body; the cap having a fluid connector for connection to a dialysis system;a draw tube downwardly extending through the container body; the draw tube connected to the cap; anda filter connected to the container body; the filter separating the container body into the top portion and a bottom portion; andthe draw tube downwardly extending through the filter into the bottom portion.2. The infusate container of claim 1 , further comprising an inwardly tapering portion in the bottom portion of the infusate container.3. The infusate container of claim 1 , further comprising a removable film on a top side of the cap.4. The infusate container of claim 1 , the filter connected to the container body by any of glue claim 1 , heat sealing claim 1 , or welding.5. The infusate container of claim 1 , wherein the filter is either a mesh or a frit filter.6. The infusate container of claim 1 , wherein the fluid connector is a bi-channel connector.7. The infusate container of claim 6 , wherein the bi-channel connector has a first channel fluidly connected to the draw tube.8. The infusate container of claim 1 , further comprising a visual indicator indicating a substance inside the container body.9. The infusate container of claim 8 , wherein the visual indicator is a colored band.10. The infusate container of claim 1 , wherein the draw tube is molded to the cap.11. The infusate ...

MONITORING SYSTEM FOR CARE PROTOCOLS

A monitoring system for care protocols, comprising sensors connected to electronic devices to input data from a patient, where sensors measure critical values from a patient; an interface for receiving data and allowing users to write and change process control in real time; a processor connected to the interface to receive input parameters, wherein the processor calculates output values based on the input parameters compared to the critical value to determine whether the output values are outside acceptable range; means for setting critical values, ranges of critical value, and alarm points when the critical values are outside of the range; where the interface receives critical patient parameters and the interface includes a manual input and a machine input from one or more sensors; and wherein the system calculates and monitors critical steps or values for a patient and enables the output values for monitoring or display, in real time. 1. A monitoring system for care protocols , wherein the system comprises:a plurality of sensors operably connected to electronic devices to input data from a patient to an interface, said sensors being disposed to measure critical values from a patient;an interface for receiving input data and allowing users to define process control limits and when appropriate change these limits of a process control in real time, as appropriate for the care of the specific patient;a means for authorized practitioners to formally document the decision to deviate from a medical facility defined protocol or the specific patient care plan;a processor operably connected to the interface to date stamp and receive, agnostically, data signals corresponding to received data input pertaining to one or more input parameters, wherein specific data values collected from the multiple data sources may be used in more than one output calculation formula, the processor calculates one or more output values based on the one or more input parameters and compares said ...

Medical apparatus for the preparation of medical fluid

A medical apparatus for the preparation of medical fluid is disclosed, comprising a support structure, a movable member, biasing means, and locking means. The movable member is mounted to the support structure and the biasing means are configured to operate in at least one of a repulsion mode and an attraction mode In the repulsion mode, the biasing means exert on the movable member a biasing force directing the movable member away from its retracted configuration, and in the attraction mode, the biasing means exert on the movable member a biasing force directing the movable member towards its retracted configuration. A blood treatment apparatus comprising the medical apparatus for the preparation of fluid, a method of setting up the medical apparatus, and a method for use of the apparatus are also disclosed.

Cartridges and Systems for Outside-In Flow in Membrane-Based Therapies

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

DIALYSIS SYSTEM AND METHODS

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration. 1. A method of priming a tubing set and a dialyzer of a dialysis system , comprising the steps of:connecting an arterial line of the tubing set to a venous line of the tubing set to form a continuous loop in the tubing set;operating a blood pump of the dialysis system to flow saline from a saline source into the arterial line and into a blood-side of the dialyzer and into a venous drip chamber; andoperating the blood pump in a reverse mode to flow saline from the venous drip chamber into the blood-side of the dialyzer in a direction opposite to a direction of blood flow during dialysis therapy.2. The method of claim 1 , further comprising:monitoring a fluid level of the saline in a venous drip chamber of the tubing set; andstopping operation of the blood pump when the fluid level in the venous drip chamber stabilizes.3. The method of claim 1 , further comprising:monitoring the tubing set for the presence of air; andstopping operation of the blood pump when air no longer ...

RENAL FAIL URE THERAPY SYSTEM AND METHOD OF CLEANING USING CITRIC ACID

A renal failure therapy system () includes a dialysis fluid circuit () including a dialysis fluid pump (); a source () of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source () of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer () in operable communication with the dialysis fluid pump (), the logic implementer () causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source () to be added to purified water from the purified water source () to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump () to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit () without a subsequent rinse. 121-. (canceled)22: A renal failure therapy system comprising:a dialysis fluid circuit including a dialysis fluid pump;a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit;a source of purified water in fluid communication with the dialysis fluid circuit; anda logic implementer in operable communication with the dialysis fluid pump, the logic implementer programmed to cause the physiological cleaning, disinfecting, and/or decalcifying substance to be added from its source to purified water from the purified water source to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect, or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse.23: The renal failure therapy system of claim 22 , wherein the physiological cleaning claim 22 , disinfecting claim 22 , and/or decalcifying substance includes an acid.24: The renal failure therapy system of claim 23 , wherein the acid is at least partially citric acid.25: The renal failure therapy system ...

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

A control system () is arranged to control the operation of an apparatus () for extracorporeal blood treatment. The apparatus () comprises an extracorporeal blood circuit () and a connection system (C) for connecting the blood circuit () to the vascular system of a patient. The blood circuit () comprises a blood processing device (), and at least one pumping device (). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit () to pump blood from the vascular system via the connection system (C) through the blood processing device () and back to the vascular system via the connection system (C). The control system () is operable to obtain measurement data from at least one energy transfer sensor () arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (). The control system () is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit () to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus () for blood treatment, such as a dialysis machine. 1. (canceled)2. The apparatus of claim 3 , wherein the transfer of energy involves at least one of a pressure wave and an electrical current.3. An apparatus for extracorporeal blood treatment claim 3 , comprising: a blood processing device; and', 'at least one pumping device;, 'an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to the vascular system of a patient, the extracorporeal blood circuit comprisingat least one energy transfer sensor comprising at least one of ...

METHOD OF FLUSHING A DIALYZER

The present invention relates to a method of flushing a dialyzer with a flushing liquid, wherein the dialyzer is arranged in a dialyzate-side circuit of a blood treatment device and wherein the dialyzer has at least one dialyzate-side chamber which has at least one inlet and at least one outlet for the flushing liquid and which is flowed through by the flushing liquid, wherein at least one property of the flushing liquid is measured at the outlet of the dialyzer or downstream of the dialyzer in the dialyzate-side circuit to obtain one or more outlet-side measured values, wherein the property depends on the quantity of the air in the flushing liquid. 1. A method of flushing a dialyzer with a flushing liquid , wherein the dialyzer is arranged in a dialyzate-side circuit of a blood treatment device and wherein the dialyzer has at least one dialyzate-side chamber which has at least one inlet and at least one outlet for the flushing liquid and which is flowed through by the flushing liquid , characterized in that at least one property of the flushing liquid is measured at the outlet of the dialyzer or downstream of the dialyzer in the dialyzate-side circuit to obtain one or more outlet-side measured values , wherein the measured property depends on the quantity of the air in the flushing liquid.2. A method in accordance with claim 1 , characterized in that the conductivity of the flushing liquid or the speed of sound at which sound propagates in the flushing liquid or an optical property of the flushing liquid is measured.3. A method in accordance with claim 1 , characterized in that at least one property of the flushing liquid is likewise measured at the inlet of the dialyzer or upstream of the dialyzer to obtain one or more inlet-side measured values claim 1 , wherein the measured property depends on the quantity of the air in the flushing liquid and wherein the inlet-side measured value or values are compared with the outlet-side measured value or values.4. A method ...

Extracorporeal Circulation Apparatus and Method of Discharging Bubbles Therefrom

An extracorporeal circulation apparatus including a blood circuit including an arterial blood circuit and a venous blood circuit whose proximal ends are connected to a blood purifier, the blood circuit allowing a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a discharge unit through which a priming solution supplied into the blood circuit is discharged to an outside; a negative-pressure-generating unit that generates a negative pressure in a region of the blood circuit, the region being filled with the priming solution; and a control unit that controls the negative-pressure-generating unit. The control unit executes a priming step in which the priming solution supplied into the blood circuit is discharged through the discharge unit while a flow route in the blood circuit is filled with the priming solution; a negative-pressure-generating step in which, after the priming step, a negative pressure is generated in the region by the negative-pressure-generating unit; and a discharge step in which bubbles in the region subjected to the negative pressure generated in the negative-pressure-generating step are caused to flow and are discharged through the discharge unit. 1. An extracorporeal circulation apparatus comprising:a blood circuit including an arterial blood circuit and a venous blood circuit whose proximal ends are connected to a blood purifier, the blood circuit allowing a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;a discharge unit through which a priming solution supplied into the blood circuit is discharged to an outside;a negative-pressure-generating unit that generates a negative pressure in a region of the blood circuit, the region being filled with the priming solution; anda control unit that controls the negative-pressure-generating unit,wherein the control unit executesa ...

Blood Purification Apparatus and Method of Discharging Bubbles Therefrom

Microbubbles detached from a blood circuit and a blood purification unit are discharged with the use of a backflow generated at the instant that a roller of a blood pump releases a squeezable tube. In a normal rotation step, a region filled with a priming solution after a priming step is closed by a closing unit, and a rotor of a blood pump is rotated normally until a roller of the blood pump releases a squeezable tube to generate a backflow. After the backflow is generated at the release of the squeezable tube by the roller of the blood pump, bubbles are moved by reversely rotating the rotor while disabling the closing by the closing unit. Thus, the bubbles are discharged through a discharge unit. 1. A blood purification apparatus comprising:a blood circuit including an arterial blood circuit and a venous blood circuit and allowing a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;a blood purification unit connected to a proximal end of the arterial blood circuit and to a proximal end of the venous blood circuit and that purifies the blood flowing through the blood circuit;a squeezable tube connected to the arterial blood circuit;a blood pump formed of a peristaltic pump that delivers liquid by squeezing, with a roller, the squeezable tube while a rotor is driven to rotate, the blood pump delivering the liquid from the distal end of the arterial blood circuit toward the blood purification unit when the rotor is rotated normally such that the roller moves in a lengthwise direction of the squeezable tube, the blood pump delivering the liquid from the blood purification unit toward the distal end of the arterial blood circuit when the rotor is rotated reversely such that the roller moves in the lengthwise direction of the squeezable tube;a discharge unit through which a priming solution supplied into the blood circuit is discharged to an outside;a closing unit that generates a ...

METHOD OF PURGING GAS BUBBLES IN AN EXTRACORPOREAL BLOOD CIRCUIT

The invention relates to a method of purging gas bubbles from at least one target zone of an extracorporeal blood circuit, preferably of an extracorporeal blood circuit of a dialysis machine, with a flushing liquid, wherein the flow rate and/or the pressure of the flushing liquid in the extracorporeal blood circuit is/are inconstant at least at times during the flushing process; and/or wherein the flow rate of the flushing liquid in the extracorporeal blood circuit lies above a range of possible flow rates at least at times during the flushing process, which range is used during the treatment for the blood. The invention furthermore relates to an extracorporeal blood treatment unit having an extracorporeal blood circuit, a pump and a control unit, with the control unit being configured to carry out a flushing process in accordance with the invention. The invention furthermore relates to an extracorporeal blood treatment unit having an extracorporeal blood circuit, a pump and a control unit, with the control unit being configured such that the conveying speed for blood is slowly increased after a standstill of the pump or after an operation of the pump at throttled speed. 1. A method of purging gas bubbles from at least one target zone of an extracorporeal blood circuit , preferably of an extracorporeal blood circuit of a dialysis machine , with a flushing liquid ,characterized in that the flow rate and/or the pressure of the flushing liquid in the extracorporeal blood circuit is inconstant at least at times during the flushing process; and/or in that the flow rate of the flushing liquid in the extracorporeal blood circuit lies outside a range of possible flow rates at least at times during the flushing process, which range is used during the treatment for the blood.2. A method in accordance with claim 1 , characterized in that the flushing liquid is conveyed through the target zone using a pump; and in that the variation of the flow rate and/or of the pressure takes ...

METHOD OF FLUSHING AN EXTRACORPOREAL BLOOD CIRCUIT

The invention relates to a method of flushing an extracorporeal blood circuit, preferably an extracorporeal blood circuit of a dialysis machine, with a flushing liquid, wherein the flushing liquid contains an anticoagulant agent, preferably heparin. The invention further relates to an extracorporeal blood treatment unit, preferably to a dialysis machine, having an extracorporeal blood circuit and a control unit, wherein the control unit is configured to carry out a flushing method in accordance with one of the preceding claims before the start of the treatment and/or intermittently during the treatment. 1. A method of flushing an extracorporeal blood circuit , preferably an extracorporeal blood circuit of a dialysis machine , with a flushing liquid ,characterized in that the flushing liquid contains an anticoagulant agent, preferably heparin.2. A method in accordance with claim 1 , characterized in that the extracorporeal circuit is completely filled with the flushing liquid; and/or in that the flushing liquid remains stationary in the circuit for a certain dwell time and is optionally moved or is circulated in a short-circuited circuit.3. A method in accordance with claim 2 , characterized in that the dwell time amounts to between 4 and 15 minutes claim 2 , preferably to between 8 and 12 minutes.4. A method in accordance with claim 2 , characterized in that the flushing liquid is displaced from the circuit at the end of the dwell time.5. A method in accordance with claim 4 , characterized in that the displacement takes place using a flushing liquid which likewise contains an anticoagulant agent claim 4 , preferably heparin; or in that the displacement takes place using a flushing liquid which is free of the anticoagulant agent.6. A method in accordance with claim 4 , characterized in that the process of the remaining of the flushing liquid in the circuit and the subsequent displacement is repeated at least twice and optionally several times.7. A method in ...

Blood Treatment Device Priming Devices, Methods, and Systems

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized. 1. A method of preparing a blood circuit element , comprising:connecting a priming fluid container of priming fluid to a blood treatment device blood inlet and connecting a drain container to a blood treatment device blood outlet;the connecting includes selecting a drain container with an internal volume that is less than a volume of priming fluid in the priming fluid container plus an internal volume of the blood treatment device and connections between the blood treatment device and the priming fluid and container and drain container;elevating the priming fluid container above the drain container to cause a flow of priming fluid through the blood treatment device into the drain container to flush and fill the blood treatment device with priming fluid; andhalting a flow of priming fluid by permitting the flow to continue until the drain container is full, thereby causing the flow to stop by supporting a fluid column between the fluid in the priming fluid container and a bottom of the drain container.2. The method of claim 1 , further comprising disconnecting the blood treatment device and connecting it to a blood treatment system.3. The method of claim 2 , wherein the disconnecting includes sealing fluid lines connected to the blood treatment device.4. The method of claim 3 , wherein the sealing includes disconnecting self-sealing connectors of a fluid circuit connected to the blood treatment device.5. A ...

SORBENT MANIFOLD FOR A DIALYSIS SYSTEM

The present invention relates to a sorbent manifold and related systems and methods having a plurality of passageways fluidly connectable to one or more valves and one or more sensors and components for use in a sorbent dialysis system. The sorbent manifold can control the one or more valves to direct fluid to either pass through a sorbent cartridge or bypass the sorbent cartridge based on measurements obtained from sensors. 1. A sorbent manifold system , comprising:at least a first inlet and a first outlet in a sorbent manifold; the sorbent manifold comprising a plurality of passageways fluidly connectable to the first inlet and first outlet and to a sorbent dialysis system;one or more valves and one or more sensors in the sorbent manifold,a controller controlling the one or more valves to direct fluid to either pass through a sorbent cartridge in the sorbent dialysis system or bypass the sorbent cartridge based on measurements of the one or more sensors; andat least a second inlet fluidly connectable to an outlet of the sorbent cartridge, wherein the controller controls the fluid to enter the second inlet from the outlet of the sorbent cartridge.2. The sorbent manifold system of claim 1 , wherein the one or more valves comprise at least a first valve and a second valve claim 1 , the controller in communication with the first valve and the second valve; the controller controlling the first valve and second valve to direct the fluid from one of the first inlet and the second inlet to one of the first outlet and a second outlet.3. The sorbent manifold system of claim 2 , wherein the controller is programmed to selectively direct the fluid from the first inlet to either the first outlet or second outlet based on data from the one or more sensors.4. The sorbent manifold system of claim 3 , wherein the at least one sensor includes a pressure sensor; and wherein the controller selectively directs fluid from the first inlet to the second outlet if a pressure is above a ...

METHOD OF PURGING GAS BUBBLES IN AN EXTRACORPOREAL BLOOD CIRCUIT

The invention relates to a method of purging gas bubbles from a target zone of an extracorporeal blood circuit of a dialysis machine, wherein the target zone is flowed through by flushing liquid which enters into the target zone through an inflow and exits it again through an outflow, wherein the inflow differs from the arterial port and the outflow differs from the venous port of the extracorporeal blood circuit. The invention furthermore relates to a dialysis machine having an extracorporeal blood circuit and a control unit, with the extracorporeal blood circuit having an inflow and an outflow for flushing liquid, with the inflow differing from the arterial port and the outflow differing from the venous port of the extracorporeal blood circuit, and with the control unit being configured to carry out a method in accordance with the invention. The invention furthermore relates to a disposable for the dialysis treatment, wherein the disposable comprises an arterial line, elements of a blood pump, a dialyzer and a venous line, wherein the disposable has an interface for the inflow of flushing liquid in the arterial line and an interface for the outflow of flushing liquid in the venous line, and wherein the interface for the inflow differs from the arterial port and the interface for the outflow differs from the venous port of the hose set. 1. A method of purging gas bubbles from a target zone of an extracorporeal blood circuit , preferably of an extracorporeal blood circuit of a dialysis machine , wherein the target zone is flowed through by a flushing liquid which enters into the target zone through an inflow and exits it again through an outflow ,characterized in that the inflow differs from the arterial port and the outflow differs from the venous port of the extracorporeal blood circuit.2. A method in accordance with claim 1 , characterized in that the outflow is arranged in the venous line; and/or in that the outflow is arranged downstream of all existing ...

METHOD FOR PRIMING HOLLOW-FIBER MEMBRANE MODULE

Provided is a priming method including a step of filling a priming liquid in a hollow-fiber membrane module in which hollow-fiber membranes are packed in a vessel having an inlet port, an outlet port, and a filtrate discharge port at a linear velocity of 20 cm/min or more and 550 cm/min or less through the inlet port or the outlet port in an amount of 15% or more relative to a volume of the hollow-fiber membrane module. According to the present invention, the effective filtration area at the time of cell suspension treatment is increased, and the recovery rate of cells and the filtration rate can be improved. Further, since the cell treatment can be completed while maintaining the closed environment, the obtained cells can be provided for therapeutic applications. 1. A method for priming a hollow-fiber membrane module in which hollow-fiber membranes are packed in a vessel having an inlet port , an outlet port , and a filtrate discharge port , comprising: filling a priming liquid in the hollow-fiber membrane module in an amount of 15% or more relative to a volume of the hollow-fiber membrane module at a linear velocity of 20 cm/min or more and 550 cm/min or less from the inlet port or the outlet port of the hollow-fiber membrane module.2. The method according to claim 1 , wherein a pressure difference between internal pressure and external pressure of a hollow fiber membrane at the time of priming is 7 mmHg or more and 29 mmHg or less.3. The method according to claim 2 , wherein the internal pressure is negative pressure.4. The method according to claim 1 , wherein the linear velocity is 35 cm/min or more and 450 cm/min or less.5. The method according to claim 1 , wherein the priming liquid is filled in the hollow-fiber membrane module in an amount of 70% or more relative to a volume of the hollow-fiber membrane module.6. The method according to claim 1 , wherein the priming liquid is introduced into the inside of the hollow fiber membrane.7. The method according to ...

Method and System for Filling and Venting a Device for Extracorporeal Blood Treatment, with Stepped Flooding of a Filter

A method for filling and venting a device for extracorporeal blood treatment is disclosed, such as a patient module in a heart-lung machine, without attached patient. A filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the system into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir, wherein a first controllable valve (HC) for a venting line of a filter is opened and, after the response of an upper filling level sensor in the reservoir, is closed. An upper level of the filter is positioned higher than the upper filling level sensor, and a start-stop motion of the blood pump is performed, as a result of which a stepped flooding of the filter is made providing for an advantageous de-airing of the device. 11. Method for filling and venting a device for extracorporeal blood treatment , such as a patient module in a system , such as a heart-lung machine , without attached patient , wherein a filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the device into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir , wherein a first controllable valve (HC) for a venting line of a filter is opened and , after the response of an upper filling level sensor in the reservoir , is closed , wherein an upper level of the filter is positioned higher than the upper filling level sensor , and a start-stop motion of the blood pump is performed , as a result of which a stepped flooding of the filter is made.2. Method according to claim 1 , wherein the blood pump filled with filling liquid is operated at periodic intervals at a first claim 1 , low speed claim 1 , which conveys filling liquid from the reservoir into an oxygenator and onwards into an arterial filter claim 1 , wherein the first speed is chosen such that a slow filling of the filter from the inlet side takes place claim 1 ...

BLOOD PURIFICATION APPARATUS AND PRIMING METHOD THEREOF

There are provided a blood purification apparatus and a priming method thereof which can reliably perform air bubble purging of a blood purification device while workability is maintained during priming. During the priming, an air purging step is performed by causing a blood pump to perform reverse rotation, and electromagnetic valves and are brought into an opened state so as to open the overflow line (L) and a priming solution supply line and so as to discharge a priming solution from an overflow line while supplying a dialysate functioning as the priming solution from the priming solution supply line. 1: A blood purification apparatus comprising:a blood circuit that includes an arterial blood circuit and a venous blood circuit, and that can extracorporeally circulate blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;a blood purification device that purifies the blood flowing in the blood circuit by being interposed between the arterial blood circuit and the venous blood circuit of the blood circuit, that has a blood flow route through which the blood of the patient flows via a blood purification membrane for purifying the blood and a dialysate flow route through which a dialysate flows, and that has a blood inlet which can introduce the blood to the blood flow route, a blood outlet which can draw out the blood from the blood flow route, a dialysate inlet which can introduce the dialysate to the dialysate flow route, and a dialysate outlet which can discharge the dialysate from the dialysate flow route;a blood pump that is arranged in the arterial blood circuit, and that is capable of forward rotation which rotates in a direction of circulating the blood during blood purification treatment and reverse rotation which rotates in a direction opposite to the direction of circulating the blood during the blood purification treatment;a priming solution supply line that is connected to the blood circuit, and ...