ИНГАЛЯЦИОННОЕ УСТРОЙСТВО И СПОСОБ ЕГО ИСПОЛЬЗОВАНИЯ

Группа изобретений относится к медицинской технике, а именно к портативному ингаляционному устройству для подачи распыляемого аэрозоля медицинского назначения для ингаляционной терапии и способу образования распыляемого аэрозоля жидкости (F) медицинского назначения. Устройство содержит (a) корпус (1), имеющий обращенную к пользователю сторону. Устройство включает (b) сопло (6) ударного типа для образования распыляемого аэрозоля посредством столкновения по меньшей мере двух потоков жидкости. Сопло (6) является прикрепленным к обращенной к пользователю стороне корпуса (1) таким образом, что оно является неподвижным относительно корпуса (1). Устройство имеет (c) резервуар (2) для текучей среды, размещенный внутри корпуса (1). Устройство содержит (d) нагнетательный блок, размещенный внутри корпуса (1). Нагнетательный блок имеет расположенный раньше по ходу текучей среды конец, который сообщается посредством текучей среды с резервуаром (2) для текучей среды. Нагнетательный блок включает расположенный ...

НАЗАЛЬНЫЕ УСТРОЙСТВА (ВАРИАНТЫ)

Изобретение относится к медицине. Устройство содержит наконечник для размещения в ноздре пациента, блок подачи вещества, предназначенный для подачи вещества, подлежащего доставке, через наконечник, и механизм предотвращения доставки вещества через наконечник до тех пор, пока наконечник не будет правильно размещен в ноздре пациента. Варианты устройства отличаются выполнением средств, предотвращающих доставку. Решена задача обеспечения доставки при правильном размещении в ноздре пациента. 3 н. и 37 з.п. ф-лы, 13 ил.

СИСТЕМА ПОДАЧИ НИКОТИНА

Группа изобретений относится к медицинской технике. Система подачи никотина содержит приводной механизм и корпус, который обладает продольной осью и который образует камеру, выполненную для расположения плунжера и содержащую выпускное отверстие для прохода состава из камеры. Приводной механизм содержит привод и приводной элемент. Привод так взаимодействует с приводным элементом, что плунжер расположен в камере, плунжер и камера перемещаются относительно друг друга в осевом направлении на заранее заданное пошаговое расстояние в ответ на каждую операцию привода с целью перемещения заранее заданного объема состава из камеры через указанное выпускное отверстие. 2 н. и 16 з.п. ф-лы, 53 ил.

УСТРОЙСТВО ДЛЯ НАЗАЛЬНОЙ ДОСТАВКИ ЛЕКАРСТВЕННЫХ СРЕДСТВ

Группа изобретений относится к медицине и медицинской технике и может быть использована для доставки композиции в обонятельную область назальной полости. Предложено устройство, содержащее контейнер, диффузор, камеру для композиции и сопло. При этом контейнер вмещает пропеллент. Диффузор сообщается и с контейнером, и с камерой для композиции. Сопло сообщается с камерой для композиции. Предложен способ с использованием этого устройства для доставки композиции в обонятельную область назальной полости. Изобретения обеспечивают эффективное введение композиции в обонятельную область и соответственно её доставку через гематоэнцефалический барьер за счёт усовершенствования механизма доставки большей части распылённого лекарственного препарата в верхнюю часть назальной полости для увеличения экспозиции в обонятельном эпителии. 2 н. и 31 з.п. ф-лы, 25 ил., 4 табл., 5 пр.

ПРИГОДНЫЙ К РАСПЫЛЕНИЮ АДГЕЗИВНЫЙ К КОЖЕ/СЛИЗИСТОЙ ОБОЛОЧКЕ ПРЕПАРАТ ГЕЛЕВОГО ТИПА И СИСТЕМА ДЛЯ ВВЕДЕНИЯ С ИСПОЛЬЗОВАНИЕМ ПРЕПАРАТА

Настоящее изобретение относится к химико-фармацевтической промышленности и касается пригодного к распылению адгезивного к коже/слизистой оболочке препарата гелевого типа, включающего гелевый состав, который содержит активный фармацевтический ингредиент в материале на гелевой основе, включающий адгезивное средство для кожи/слизистой оболочки, причем адгезивное средство для кожи/слизистой оболочки включает карбоксивинильный полимер и, в случае необходимости, геллановую камедь, и его вязкость регулируется приложением внешней сдвиговой нагрузки, и к системе для введения, включающей этот препарат. Препарат обладает высокой адгезионной способностью и высокой стабильностью. 2 н. и 20 з.п. ф-лы, 19 табл., 14 ил.

САМОПРОКАЛЫВАЮЩИЙСЯ КАРТРИДЖ С ЖИДКИМ ЛЕКАРСТВЕННЫМ СРЕДСТВОМ И СВЯЗАННЫЙ С НИМ ДОЗАТОР

Изобретение относится к медицинской технике, а именно к самопрокалывающимся картриджам с жидким лекарственным средством и связанному с ними ингалятору, используемым для доставки одной или нескольких отдельно взятых доз переведенного в аэрозольное состояние жидкого лекарственного средства. Самопрокалывающийся картридж содержит: контейнер в сборе, содержащий: контейнер, предназначенный для хранения жидкого лекарственного средства; перегородку, предназначенную для герметизации первого конца контейнера; поршень, герметизирующий второй конец контейнера, причем поршень выполнен с возможностью перемещения относительно контейнера таким образом, чтобы выборочно выталкивать объем жидкого лекарственного средства из контейнера через полую иглу; и иглу в сборе, выполненную с возможностью перехода между первой конфигурацией, в которой полая игла не продолжается через перегородку, и второй конфигурацией, в которой полая игла продолжается через перегородку. При этом игла в сборе содержит: колпачок, выполненный ...

НИЗКОТЕМПЕРАТУРНОЕ ЭЛЕКТРОННОЕ УСТРОЙСТВО ИСПАРЕНИЯ И СПОСОБЫ

... 1. Устройство для образования ингалируемого аэрозоля, содержащее:(a) корпус; и(b) электронный нагреватель, выполненный для нагрева испаряемого материала и образования ингалируемого аэрозоля; причем электронный нагреватель расположен внутри указанной наружной поверхности указанного корпуса, отличающееся тем, что указанное устройство содержит рядом с указанным электронным нагревателем теплоизоляцию из аэрогеля, выполненную для поддержания теплопроизводительности испаряемого материала и снижения температуры поверхности наружной поверхности.2. Устройство по п. 1, отличающееся тем, что теплоизоляция из аэрогеля содержит силикагель с армирующими волокнами.3. Устройство по п. 1, отличающееся тем, что теплоизоляция из аэрогеля представляет собой эластичное покрытие из силикагеля.4. Устройство по любому из пп. 1-3, отличающееся тем, что теплоизоляция из аэрогеля выбрана из группы, состоящей из углеродного аэрогеля и алюмооксидного аэрогеля.5. Устройство по п. 1, отличающееся тем, что содержит уплотнение ...

АЭРОЗОЛЬНОЕ СРЕДСТВО С УПЛОТНИТЕЛЕМ РАСПЫЛИТЕЛЯ

... 1. Средство для распыления заданного количества жидкости, содержащее кожух (1) и распылитель (5) для размещения распылительного сосуда (2) в свободном пространстве (3) кожуха (1), ! отличающееся тем, что ! кожух (1) содержит активирующее устройство (7, 8а, 8b), образованное двумя противоположными боковыми поверхностями (7) в виде нажимных поверхностей в нижней части кожуха (1) и, по меньшей мере, одним рычагом (8а, 8b), установленным шарнирно и выполненным интегрально с этими боковыми поверхностями, ! при этом рычаги (8а, 8b) предназначены для поворота ко дну (14) аэрозольного сосуда (2), когда он вставлен в кожух (1) и расположен в свободном пространстве (3), благодаря чему усилия (Р), приложенные в противоположных направлениях к боковым поверхностям (7), преобразуются в осевое перемещение активирующего устройства, которое выталкивает аэрозольный сосуд (2) к распылителю (5), ! кожух (1), распылитель (5) и активирующее устройство (7, 8а, 8b) выполнены интегрально; ! для минимизации остаточного ...

АЭРОЗОЛЬНЫЙ АСПИРАТОР И СПОСОБ ВСАСЫВАНИЯ АЭРОЗОЛЯ

... 1. Аэрозольный аспиратор, включающий ! корпус с мундштуком, включающий впускное отверстие для наружного воздуха, открытое на его наружной поверхности, ! генерирующее устройство, размещенное внутри корпуса, для формирования аэрозоля, при этом генерирующее устройство включает ! канал формирования аэрозоля, проходящий от впускного отверстия для наружного воздуха до мундштука и имеющий место распределения и распылительную поверхность в своей средней части, !питающий насос, имеющий растворную камеру, содержащую раствор, преобразуемый в аэрозоль, для подачи раствора из растворной камеры в место распределения в фиксированном количестве каждый раз, когда приводится в действие питающий насос, и ! распылительное приспособление для распыления раствора, подведенного в место распределения у распылительной поверхности. ! 2. Аэрозольный аспиратор по п.1, в котором канал формирования аэрозоля представляет собой трубчатый канал. ! 3. Аэрозольный аспиратор по п.2, в котором распылительное приспособление ...

СПОСОБ И СИСТЕМА ДЛЯ ВВЕДЕНИЯ ЛЕГОЧНОГО СУРФАКТАНТА ПУТЕМ ПУЛЬВЕРИЗАЦИИ

РАСПЫЛИТЕЛЬ, В ЧАСТНОСТИ ИНГАЛЯТОР, ДЛЯ РАСПЫЛЕНИЯ ЖИДКОГО ДЕЙСТВУЮЩЕГО ВЕЩЕСТВА В АЭРОЗОЛЬ, А ТАКЖЕ СООТВЕТСТВУЮЩИЙ СПОСОБ

СИСТЕМА И СПОСОБ КОНТРОЛИРУЕМОГО МЕДИКАМЕНТОЗНОГО ЛЕЧЕНИЯ

РИНОВАКЦИНАЦИОННАЯ СИСТЕМА ДЛЯ ВАКЦИНЫ ПРОТИВ ГРИППА

ЕМКОСТЬ ДЛЯ ТЕКУЧЕЙ СРЕДЫ И СИСТЕМА БЕЗВОЗДУШНОГО ДОЗИРОВАНИЯ ТЕКУЧЕЙ СРЕДЫ С ИСПОЛЬЗОВАНИЕМ УПОМЯНУТОЙ ЕМКОСТИ

... 1. Емкость для текучей среды, содержащая: ! корпус емкости, содержащий верхнее и нижнее отверстия и дополнительно содержащий плечевой элемент и боковую стенку, которая продолжается между верхним и нижним отверстиями; ! ограничитель, примыкающий к плечевому элементу упомянутого корпуса емкости; ! скользящий клапан, совершающий скользящее движение по внутренней поверхности боковой стенки упомянутого корпуса емкости, при герметичном уплотнении между ними, при этом упомянутый скользящий клапан в сочетании с боковой стенкой упомянутого корпуса емкости ограничивает пространство емкости для вмещения текучей среды; и ! нижнюю крышку, перекрывающую нижнее отверстие упомянутого корпуса емкости; ! причем упомянутый ограничитель и упомянутый скользящий клапан содержат поверхность ограничителя и поверхность клапана, соответственно которые расположены взаимно противоположно друг другу и наклонены под углами наклона от 5 до 30° относительно горизонтальной поверхности. !2. Емкость по п.1, в которой поверхность ...

ПРИГОДНЫЙ К РАСПЫЛЕНИЮ АДГЕЗИВНЫЙ К КОЖЕ/СЛИЗИСТОЙ ОБОЛОЧКЕ ПРЕПАРАТ ГЕЛЕВОГО ТИПА И СИСТЕМА ДЛЯ ВВЕДЕНИЯ С ИСПОЛЬЗОВАНИЕМ ПРЕПАРАТА

... 1. Пригодный к распылению адгезивный к коже/слизистой оболочке препарат гелевого типа, включающий гелевый состав, который содержит активный фармацевтический ингредиент в материале на гелевой основе, включающем адгезивное средство для кожи/слизистой оболочки. ! 2. Пригодный к распылению адгезивный к коже/слизистой оболочке препарат гелевого типа по п.1, в котором обрабатываемая слизистая оболочка представляет собой слизистую оболочку носовой полости, глаза, уха, ротовой полости, прямой кишки, влагалища или мочеиспускательного канала; или обрабатываемая кожа представляет собой кожу руки, пальца, ноги, тела, паховой области, кожу головы, области заднепроходного отверстия или области гениталий. ! 3. Пригодный к распылению адгезивный к коже/слизистой оболочке препарат гелевого типа по п.1, в котором обрабатываемая слизистая оболочка представляет собой слизистую оболочку носовой полости. !4. Пригодный к распылению адгезивный к коже/слизистой оболочке препарат гелевого типа по любому из пп.1-3 ...

SPENDER MIT EINSTELLBARER DOSIERMENGE

Einwegdosierer

Einwegdosierer für medizinische oder kosmetische Anwendungen mit einer Ampulle (12), die in einem Reservoir (14) ein medizinisches Produkt aufnimmt, einem in das Reservoir (14) eingesetzten hohlen Kolben (22), einem in die Querschnittsöffnung des Kolbens (22) eingesetzten Reduzierstab (26) mit einem Kopf (30), wobei zwischen dem Kopf (30) und einem Wandbereich (34) um ein Düsenloch (36) zur Ausgabe des medizinischen Produktes Einlaufkanäle (38) zum Düsenloch (36) hin angeordnet sind, und einem gemeinsam mit dem Kolben (22) relativ zur Ampulle (12) beweglichen Trägerkörper (16), dadurch gekennzeichnet, dass der Wandbereich (34) um das Düsenloch (36) einstückig mit dem Trägerkörper (16) ausgebildet ist und die Einlaufkanäle (38) als Nuten in der Stirnfläche des Kopfes (30) und/oder der Innenfläche des Wandbereiches (34) angeordnet sind wobei der Trägerkörper (16) zwei Stufen aufweist, an denen der Kolben (22) anliegt.

Vakuummotor zum Betreiben eines Lavage-Systems und Verfahren zum Erzeugen einer periodischen Bewegung

Vakuummotor (1) aufweisend einen Arbeitskolben (12), einen Innenraum, in dem der Arbeitskolben (12) linear beweglich angeordnet ist, ein Rückstellelement (22), das zumindest zeitweise eine in Richtung einer Vorderseite (4) des Innenraums wirkende Kraft auf den Arbeitskolben (12) ausübt, eine Gaseinlassöffnung (24) zum Einspeisen von Umgebungsluft oder eines unter Druck stehenden Gases in den Innenraum und eine Gasauslassöffnung (26) zum Abführen des Gases aus dem Innenraum, wobei die Gasauslassöffnung (26) an eine Unterdruckquelle anschließbar ist, wobei zwischen dem Arbeitskolben (12) und einer Rückseite (6) des Innenraums ein Steuerkolben (14) linear beweglich im Innenraum angeordnet ist, wobei der Steuerkolben (14) in einer ersten Position die Gasauslassöffnung (26) nicht abdeckt und die Gaseinlassöffnung (24) abdeckt und in einer zweiten Position die Gaseinlassöffnung (24) nicht abdeckt und die Gasauslassöffnung (26) abdeckt, der Steuerkolben (14) gegen den Arbeitskolben (12) beweglich ...

Single dose dispenser

Medicament delivery device for administration of opioid antagonists including formulations for naloxone

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

DISPENSING DEVICE

ATOMISING PUMP

Cleaning aid

A nozzle 12 for an ear canal rinsing device (10, Fig 1B) comprises a stem structure 14 comprising a fluid supply region 20, a fluid delivery region 24, and an internal fluid passage (15, Fig 3) along the stem axis. An outer surface 30 of the stem structure comprises one or more wing structures 32, each wing structure comprising an outer ridge 34 tapering from a free end 38 towards the fluid delivery region 24. The wing structures inhibit over-insertion into an ear canal while providing a clear run-off path between the wing structures. A ridge may comprise a surface plateau narrowing in width toward the fluid delivery region. The nozzle may comprise two or more wing structures spaced equidistantly radially apart. The free end of a wing structure may extend radially from the stem structure at least one third of the diameter of the stem structure. A liquid reservoir may be connectable with the nozzle.

Nasal aerosol delivery system

NEBULIZER, INDICATOR DEVICE AND CONTAINER

Nasal aerosol delivery system

Nebulizer

Nebulizer

Nasal aerosol delivery system

Nebulizer

NEBULIZER, INDICATOR DEVICE AND CONTAINER

NEBULIZER, INDICATOR DEVICE AND CONTAINER

SYRINGE FOR A SPRAYING APPLICATION OF LIQUID ANAESTHETICS

AEROSOL GENERATOR AND PROCEDURE FOR THE PRODUCTION OF AN AEROSOL GENERATOR

AEROSOL AS WELL AS PROCEDURE AND DEVICE FOR THE AEROSOL PRODUCTION

PROCEDURE AND DEVICE FOR SPUTTERING A LIQUID

PROCEDURE FOR THE ADMINISTRATION OF A NOSE SPRAY

ATOMIZER FOR THE YIELD OF LIQUIDS FOR MEDICAL PURPOSES

IMPROVED PROCEDURE FOR THE PRODUCTION OF AN AEROSOL

DEVICE FOR THE PROPORTIONED ADMINISTRATION OF A LIQUID DRUG.

DONOR WITH ADJUSTABLE DOSING QUANTITY

ATOMIZATION EQUIPMENT, IN PARTICULAR BAG ATOMIZATION EQUIPMENT

DONOR

MORE ULTRASCHALLZERST�UBER WITH REMOVABLE ONE PR�ZISIONSDOSIEREINHEIT

Apparatus for controlled delivery of opioid and other medications

A method, system and apparatus for administering various medicaments including those for treating pain and substance dependency are disclosed. The apparatus is a unit for heat activation of a morphine opiate liquid concentrate mixed with a carrier substance to produce inhaled gas. The method includes inhaling the heat activated gaseous vapor concentrate for pain relief, to treat substance dependency or administration of other medicaments. The system includes a heat vaporization unit with security, control and communication capability to provide effective patient care and ensure safety.

N-acetylneuraminic acid compositions and methods of use

The present invention relates to the field of viral disorders, and in particular to the use of natural compounds to inhibit viruses and viral infection. Compositions comprising NANA are provided for treating or preventing viral infections, such as those causing the common cold.

Adjustable dose dispenser

METHODS AND DEVICES FOR NEBULIZING FLUIDS

Vacuum motor for operation of a lavage system

VACUUM MOTOR FOR OPERATION OF A LAVAGE SYSTEM A vacuum motor (1) comprises a working plunger (12), an internal space, in which the working plunger (12) is arranged such that it is mobile in linear direction, a resetting element (22) that exerts, at least for part of the time, a force on the working plunger (12) that acts in the direction of a front side (4) of the internal space, a gas inlet opening (24) for supplying ambient air or a compressed gas into the internal space, and a gas outlet opening (26) for discharging the gas from the internal space, whereby the gas outlet opening (26) is connectable to a negative pressure source, whereby a control plunger (14) is arranged between the working plunger (12) and a rear side (6) of the internal space such as to be mobile in linear direction in the internal space, whereby the control plunger (14), in a first position, does not cover the gas outlet opening (26) and covers the gas inlet opening (24) and, in a second position, does not cover the ...

Preparation and delivery of sustained nitric oxide releasing solutions

The present invention relates to a system and method of treating a subject with nitric oxide gas and/or nitric oxide releasing solutions. The present invention also relates to compositions and devices useful for treating a subject with nitric oxide gas and/or nitric oxide releasing solutions.

Negatively biased sealed nebulizers systems and methods

Methods, systems, and devices are described for creating a negative bias pressure within a liquid reservoir. Embodiments may include providing a liquid reservoir coupled with an aerosol generator. The liquid reservoir may be sealed to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed and the ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. Further, embodiments may include vibrating the aperture plate to dispense the portion of the liquid. The portion of the liquid dispensed may decreases the amount of the liquid in the sealed reservoir. By decreasing the amount of liquid in the sealed reservoir, a negative bias pressure between an air side and a liquid side of the aperture plate may be created.

Container, indicator device, and nebulizer

A nebulizer as well as a container and an indicator device for such a nebulizer are proposed. The indicator device is fixedly mounted from the bottom of the container and comprises a piercing element for opening an aeration of the container. The indicator device and its piercing part are preferably actuated by axial movement of the indicator device and container within the nebulizer.

Container, indicator device, and nebulizer

A nebulizer as well as a container and an indicator device for such a nebulizer are proposed. The indicator device is fixedly mounted from the bottom of the container and comprises a piercing element for opening an aeration of the container. The indicator device and its piercing part are preferably actuated by axial movement of the indicator device and container within the nebulizer.

Methods and apparatus for aerosolizing a substance

APPARATUS AND METHOD FOR ADMINISTERING OPHTHALMIC SOLUTIONS

An apparatus for dispensing a liquid product having: a) housing or frame having an opening (3a) , b) a receptacle for the liquid with a feed nozzle arranged substantially stationary with respect to the housing or frame, c) a dosing chamber (7) having a valve containing at least a first orifice and a second orifice, d) a mechanism arranged to allow ejection of liquid through the second orifice, and e) a through passage arranged to allow the ejected liquid to pass in a direction different from the feed nozzle and out of the opening (3a) , wherein i) the mechanism comprises a mobile element movable with respect to the housing or frame between at least a first position in which the first orifice of the dosing chamber and the feed nozzle are in flow communication and a second position in which the second orifice and the through passage are in flow communication, and N) the mechanism is arranged to allow aspiration of liquid through the first orifice when the mobile element is in the first position ...

AEROSOL GENERATOR AND METHODS OF MAKING AND USING AN AEROSOL GENERATOR

An aerosol generator (21) includes a flow passage (27) having an inlet (29), and an outlet (31); a heater (33) arranged relative to the flow passage for heating the flow passage, a source of material (37) to be volatilized in communication with the inlet of the flow passage; a valve (35) to open, and close communication between the source of material; the inlet of the flow passage; and a pressurization arrangement (39) for causing material in the source of material to be introduced into the flow passage when the valve is in an open position. The aerosol generator further includes a source of power (41) for operating the heater, the valve; and a control device (43) for controlling supply of power from the source of power to the heater, and the valve. A metering device (463) in an inhaler (401) includes a pressurized source of medicated fluid (408), and a metering chamber (407) configured to deliver a predetermined volume of fluid to a heated flow passage (409) in the inhaler.

NEGATIVELY BIASED SEALED NEBULIZERS SYSTEMS AND METHODS

Methods, systems, and devices are described for creating a negative bias pressure within a liquid reservoir. Embodiments may include providing a liquid reservoir coupled with an aerosol generator. The liquid reservoir may be sealed to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed and the ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. Further, embodiments may include vibrating the aperture plate to dispense the portion of the liquid. The portion of the liquid dispensed may decreases the amount of the liquid in the sealed reservoir. By decreasing the amount of liquid in the sealed reservoir, a negative bias pressure between an air side and a liquid side of the aperture plate may be created.

DISPOSITIF DE CONDITIONNEMENT DE SUBSTANCES LIQUIDES OU LIQUIDES ET SOLIDES

Ce dispositif comporte essentiellement une ampoule, de forme cylindrique, un injecteur, un cache-ampoule et un cache-embout, couplé à l'injecteur. L'ampoule est fermée à une de ses extrémités et comporte une zone cylindrique de section circulaire, large, suivie d'une seconde zone cylindrique de section circulaire large. La zone cylindrique de section circulaire rétrécie est obturée par un bouchon intermédiaire mobile qui définit avec le fond de l'ampoule un premier compartiment appelé chambre de mélange et avec un organe d'obturation, un second compartiment contenant un solvant liquide. La chambre de mélange contient avantageusement un lyophilisat prévu pour être dissout par le liquide pour former un médicament injectable ou utilisable par pulvérisation ou similaire.

ELECTRONIC VAPOUR PROVISION SYSTEM WITH AEROSOLISABLE SUBSTRATE MATERIAL DISPENSING ARRANGEMENT

A component for a vapour provision system comprises a reservoir for storing aerosolisable substrate material, the reservoir bounded by a boundary wall with at least one movable section configured to move to reduce a storage volume of the reservoir; an outlet in the reservoir for dispensing aerosolisable substrate material from the reservoir; a one-way outlet valve at the outlet configured to open for the dispensing of the aerosolisable substrate 10 material; and a dispensing arrangement operable to increase pressure of aerosolisable substrate material in an outlet volume of the reservoir which is not bounded by the movable section, so as to open the outlet valve and dispense a portion of aerosolisable substrate material, the subsequent absence of the dispensed portion reducing the pressure to allow the movable section of the boundary wall to move to reduce the storage volume.

SYSTEMS AND METHODS FOR TREATING THE NASAL CAVITY

The present disclosure provides an apparatus (200) for delivering an anesthetic agent (222) to a target tissue in a nasal cavity (100) of a patient. The apparatus (200) includes an elongated shaft (212) with a proximal end (214) and a distal end (216). The apparatus (200) also includes an absorbent plug (220) coupled to the distal end (216) of the elongated shaft (212). The absorbent plug (220) is configured to occupy a first volume in a compressed state and a second volume in an uncompressed state. The absorbent plug (220) is configured to store an anesthetic agent (222) and deliver the anesthetic agent (222) to the target tissue in the nasal cavity (100) by contacting the target tissue. The apparatus (200) also includes a sheath (224) at least partially covering the absorbent plug (220). The sheath (224) retains the absorbent plug (220) in the compressed state when positioned at least partially over the absorbent plug (220), and removal of the sheath (224) allows for the absorbent plug ...

TOPICAL ANESTHETIC COMPOSITION

A topical anesthetic composition comprising benzocaine, pharmaceutically acceptable salt thereof, amide thereof and/or ester thereof; tetracaine and/or pharmaceutically acceptable salt thereof; ethanol; polyethylene glycol; propylene glycol; water; and benzyl alcohol is provided. Also provided is method for dispensing the above topical anesthetic composition to a desired site such by spraying the topical anesthetic from a pump actuated metered dose spray device. The topical anesthetic composition can also be administered subgingivally with a syringe and applicator tip. A product comprising the above topical anesthetic spray composition contained in a pump actuated metered dose spray device.

CONCENTRATE DISPENSER

A dispenser with a housing, a plunger, and an activation mechanism coupled to the plunger. The housing defines a reservoir configured to retain a liquid and a dispensing orifice in fluid communication with the reservoir. The plunger is configured to move through the reservoir toward the dispensing orifice to dispense the liquid through the dispensing orifice. The activation mechanism is configured to be moved by a user, and movement of the activation mechanism in a first direction causes the plunger to move toward the dispensing orifice. At least one of the activation mechanism and the housing is configured to provide feedback to a user when the activation mechanism moves a predetermined distance in the first direction. A method of using the dispenser.

INHALATION DEVICE AND METHOD

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having improved flow characteristics. A inhalation device for medically active liquids (F) for generation of an aerosol com- prises a housing (1), inside this housing (1) a reservoir (2) for storing a liquid (F), a pumping device with a hollow cylinder (9) providing a pumping chamber (3) for the generation of a pressure inside said pumping chamber (3), wherein the pumping chamber is fluidically connected with the reservoir (2) via an inlet check valve (4) which blocks in direction of the reservoir (2), a riser pipe (5) which can be received with at least one reservoir-facing, interior end (5A) in said hollow cylinder (9), and a nozzle (6) which is connected liquid-tight to an exterior end (5B) of the riser pipe (5), wherein the volume of the pumping chamber (3) is changeable by means of relative motion of the cylinder (9) to the riser pipe (5), and is characterised ...

DOSE DIVIDER SYRINGE

A syringe includes a barrel having an internal surface defining an internal bore therein; a plunger having a distal end disposed within the internal bore of the barrel, and a proximal end disposed outside the internal bore of the barrel; and a dose divider configured to bear on the barrel in response to translation of the plunger relative to the barrel along the longitudinal direction. The dose divider includes a base including a flange that extends at least partly in a radial direction; and at least one column extending away from the base along the longitudinal direction. The at least one column includes a proximal end and a distal end opposite the proximal end, the proximal end of the at least one column being coupled to the base. The at least one column includes a sacrificial portion coupled to a frangible link.

MULTILIQUID-NOZZLE

The invention relates to the field of nozzles for inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle for an inhalation device, suitable for the generation of an aerosol of a medically active liquid, and to inhalation devices comprising such nozzle. Such nozzle (1) for an inhalation device for medically active liquids (F, F1, F2) for generation of an aerosol has a main axis (Z) and at least three ejection channels (1A, 1B, 1C, 1D) adapted to eject liquid (F, F1, F2) along respective ejection trajectories, wherein at least two collision points (X1, X2) are provided at which at least two of said ejection trajectories intersect with one another, and/or wherein further, all ejection angles (A, A1, A2) at which the individual trajectories leave the nozzle (1) are identical, or at least one of said ejection angles (A, A1, A2) differs from the other ejection angles (A, A1, A2).

SYSTEMS AND METHODS OF AEROSOL DELIVERY WITH AIRFLOW REGULATION

NEBULIZER

A nebulizer (1) for nebulizing a liquid (2) from a container (3) is proposed. The nebulizer comprises a fluid pump (5) for withdrawing the liquid in doses from the container and pressurizing the respective doses for nebulization. The nebulizer comprises in addition an air pump (30) with a piston / cylinder arrangement (31, 32) for pumping air into the container to pressurize the liquid in the container to help withdrawing the liquid from the container.

INTRASITE ADMINISTRATION AND DOSING METHODS AND PHARMACEUTICALS FOR USE THEREIN

A new method of targeted intrasite drug administration to wounds offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing intrasite medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large intrasite doses increase risk of toxicity from impurities allowed in drugs given by other routes. Pharmacodynamic parameters make certain drugs advantageous as intrasite agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an intrasite medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful intrasite pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration ...

ATOMIZER

In an atomizer (1) for dispensing a defined amount of a fluid (2), in par ticular one containing a pharmaceutical, as aerosol through a nozzle (12) fr om a pressure chamber (11), wherein a mechanical pressure generator (5) acts on the measured fluid (2) in the pressure chamber and is abruptly released for the atomization, a nosepiece (19) is assigned to the nozzle (12). ...

DEVICES AND METHODS FOR NEBULIZING FLUIDS FOR INHALATION

... ²²²A nebulizer comprising an aerosol generator (100) and a titration mechanism ²(20) comprising a dosing mechanism (30), a screw assembly (50), a plunger (60) ²and an actuator (40), wherein the dosing mechanism is rotatably mounted in the ²nebulizer and the plunger is mounted in the nebulizer to travel along a ²longitudinal axis (62) substantially perpendicular to the plane of rotation of ²the dosing mechanism. The actuator is mounted to the nebulizer to travel in ²the direction (42) of the longitudinal axis. The screw mechanism allows the ²rotation of the dosing mechanism to fix a variable distance of travel of the ²plunger based on the selected dose, without moving the plunger longitudinally. ²This allows the user to verify and if necessary correct the selected dose ²prior to any drug being released from the vial. Operation of the actuator ²causes longitudinal movement, through the screw mechanism, to the plunger.² ...

RHINOVACCINATION SYSTEM OF INFLUENZA VACCINE

The present invention pertains to an influenza vaccine nasal vaccination system in which an influenza vaccine composition characterized by including a gel base that contains a carboxyvinyl polymer and an influenza virus deactivated full particle antigen, and including no adjuvants, is packed into a medical syringe for administration to the mucus membrane of the nasal cavity.

INTRANASAL CARTRIDGE DEVICES

Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

DISPENSING MECHANISM FOR A MEDICAL DEVICE

A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.

DOSE DIVIDER SYRINGE

A syringe includes a barrel having an internal surface defining an internal bore therein; a plunger having a distal end disposed within the internal bore of the barrel, and a proximal end disposed outside the internal bore of the barrel, the proximal end of the plunger being opposite the distal end of the plunger along a longitudinal direction; and a dose divider. The dose divider includes a divider flange extending at least partly in a radial direction, the radial direction being perpendicular to the longitudinal direction, the divider flange having a distal surface that faces the barrel, the distal surface of the divider flange bearing on the proximal end of the plunger, and a concave shell extending away from the distal surface of the divider flange along the longitudinal direction.

INHALER

An inhaler (1) is proposed for the propellant-free nebulisation of a medicament preparation. The inhaler produces an aerosol at low speed. The inhaler is combined with an add-on device (23) for intermediate storage of the aerosol produced, so as to allow easier inhalation, particularly for children.

ATOMIZER FOR NASAL THERAPY

An atomizing nozzle structured particularly for nasal therapy. Preferred embodiments include a 2-piece atomizing nozzle structured to couple with luer-locking structure carried by a syringe. Such an atomizing nozzle includes a nasal stopper and a stem. A preferred nasal stopper includes a distal tip sized for insertion into a nostril of a human child, with a proximal shield portion being structured to resist over-insertion of a discharge orifice into the nostril. A nasal stopper desirably provides a centering function to urge the discharge orifice away from a nasal wall. One operable stem is structured to couple with the stopper and desirably carries unitary thread structure at a proximal end. A second operable stem is structured as a unitary part of the nasal stopper and also desirably carries unitary thread structure at a proximal end. Certain embodiments may also include spacer structure configured to reduce a dead volume inside the atomizing nozzle. Other embodiments may also include ...

DISPENSER COMPRISING ACTUATING PISTON AND OUTLET CHECK VALVE

A container assembly comprising a container, a valve disposed in the container and an axially movable plunger element disposed axially rearward of the valve. The plunger element defines a first volume in the container between the plunger element and the valve. The valve comprises a permanent seal sealing the valve to the container about the entire perimeter of the valve, and a channel bypassing the permanent seal and being in fluid communication with the atmosphere outside of the container assembly and being selectively sealed from the first volume by a resilient seal. The resilient seal is moveable from a sealing configuration to an open configuration upon fluid pressure in the first volume exceeding a first pressure threshold.

VENTILATOR CIRCUIT, ADAPTER FOR USE IN VENTILATOR CIRCUIT AND METHODS FOR THE USE THEREOF

An adapter includes a housing having an inlet port defining a flow path and an outlet port. An interior wall has an inner surface defining an interior passageway communicating with the outlet port and an exterior surface defining an exterior passageway communicating with the inlet port. The interior wall defines a mouth communicating between the interior and the exterior passageways. The interior wall is positioned transverse to the flow path of the inlet port. A medicament delivery port opens into the mouth. A valve is moveable between a closed position, wherein the valve closes the medicament delivery port, and an open position, wherein the medicament delivery port is open. A ventilator circuit and method of delivering a medicament are also provided.

VACUUM MOTOR FOR OPERATION OF A LAVAGE SYSTEM

The invention relates to a vacuum motor (1) comprising a working plunger (12), an internal space, in which the working plunger (12) is arranged such that it is mobile in linear direction, a resetting element (22) that exerts, at least for part of the time, a force on the working plunger (12) that acts in the direction of a front side (4) of the internal space, a gas inlet opening (24) for supplying ambient air or a compressed gas into the internal space, and a gas outlet opening (26) for discharging the gas from the internal space, whereby the gas outlet opening (26) is connectable to a negative pressure source, whereby a control plunger (14) is arranged between the working plunger (12) and a rear side (6) of the internal space such as to be mobile in linear direction in the internal space, whereby the control plunger (14), in a first position, does not cover the gas outlet opening (26) and covers the gas inlet opening (24) and, in a second position, does not cover the gas inlet opening ...

DEVICES, SYSTEMS AND METHODS FOR LOCATING AND INTERACTING WITH MEDICAMENT DELIVERY SYSTEMS

In some embodiments, a method includes establishing a communications link between a computing device and an adapter. The adapter is configured to receive at least a portion of a medicament delivery device. A wireless signal is received to maintain the communications link. A relative position between the computing device and the adapter is determined. An alarm is produced when the wireless signal is not received within a time period. The alarm is based on the relative position between the computing device and the adapter ...

DISPENSER

A dispenser (Fig. 1,4) comprises a reservoir (10) of a physiologically active substance and a droplet ejection device (14), for example a bubble jet or piezoelectric device, which is controlled to issue a predetermined number of discrete droplets of the substance from ejection orifices (15) upon actuation. Device (14) may be actuated by a pressure transducer (19) responsive to inhalation and issue the droplets into an airstream (A) which enters at slot (7) and is then inhaled via mouthpiece (5). In other embodiments (Fig. 5) the dispenser is finger actuated and directed by hand for topical application. The number and/or frequency of droplets issued is programmatically controlled by a control circuit (16) whereby average and total dose of the substance are predetermined.

DISPENSING APPARATUS

A dispensing apparatus (1) defines an outlet (3) through which a metered dose of liquid (19) from a reservoir (16) is dispersed as an atomised spray. A droplet (19) of liquid is metered onto a perforate membrane (6) which is vibrated by means of a piezoelectric transducer (10) such that atomised droplets are dispensed through the holes (7) formed in the membrane. At each actuation of a delivery means (14) which provides the metered quantity of liquid, the transducer is actuated so as to vibrate the membrane for a period greater than the dispensing period required for the droplet to be dispensed. The apparatus is particularly suitable for dispensing pharmaceutical preparations.

Distributeur portatif pour poudre à priser.

SYRINGE FOR A SPRAYING APPLICATION OF LIQUID ANAESTHETICS.

DEVICE FOR PACKAGING LIQUID SUBSTANCES OR LIQUIDS AND SOLIDS.

Portable inhaler especially for nicotine has micro plate heater fed by capillary from integral reservoir

A portable inhaler, especially for supplying controlled does of nicotine, or any other material, has a battery powered micro plate heater onto which the material is dosed via a capillary feed. The dosing process is initiated by the user sucking a mouthpiece to activate a piston dosing process. The heated material is converted into a gas or aerosol spray in an expansion chamber before entering the mouthpiece. The micro plate heater operates about 270 deg.C and the batteries can be rechargeable. The operation of the inhaler can be monitored by integral LEDs.

Device for the administration of a single dose of a fluid substance.

Head of distribution fine-dose with stopper to elastic membrane. it originates them: Head of distribution perfected fine-dose.

Testa di erogazione multi-dose, particolarmente per prodotti farmaceutici, comprendente un ugello di erogazione (21) con otturatore (10) alloggiato in una camera di dosaggio (23), in cui i mezzi di alloggiamento dellotturatore comprendono una membrana (9) elasticamente deformabile, disposta per sigillare a tenuta detta camera (23), e connessa allotturatore in modo tale da operare come elemento di sospensione elastica dellotturatore medesimo.

Bi-dose nasal spray.

Die vorliegende Erfindung betrifft ein neues Nasenspray, enthaltend eine wässrige Lösung mit einem anxiolytischen oder krampflösenden Wirkstoff, wobei das Nasenspray dadurch gekennzeichnet ist, dass mit dem Nasenspray zwei Sprühstösse mit je gleichem definiertem Volumen der wässrigen Wirkstofflösung einem Patienten intranasal verabreicht werden können und wobei das Nasenspray eine Verabreichung in jeder Lage des Patienten (aufrecht stehend, sitzend, liegend oder in jeder Zwischenposition) erlaubt. Das Nasenspray ist direkt verwendbar ohne vorherige Aktivierung. Am Nasenspray ist bevorzugt erkennbar, ob mit dem Nasenspray bereits ein Sprühstoss oder gar ein zweiter Sprühstoss erfolgt ist. Bevorzugt kann ein Sprühstoss mit dem Nasenspray einhändig vom Patienten oder einer Drittperson verabreicht werden. Der Wirkstoff im erfindungsgemässen Nasenspray ist bevorzugt Midazolam oder ein Derivat davon oder ein Salz dieser Wirkstoffe. Das Nasenspray gemäss der vorliegenden Erfindung kann zur Behandlung ...

SPRAYER, INCLUDING COUNTING DEVICE AND LOCK, BLOCKING ITS OPERATION

INHALATION TRAINER AND SYSTEM FOR TRAINING PROCESS INHALATION

SPRAYER

LOW TEMPERATURE ELECTRONIC DEVICE EVAPORATION

NEBULIZER AND CONTAINER

NEBULIZER

METERING DEVICE AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF RHINITIS

Device for intranasal administration

Disclosed herein are devices and processes for preparing a vial for an intranasal administration of a medicament where the vial comprises reduced oxygen content.

Nebulizer

A nebulizer which has an insertable container and a counter device for counting operations of the nebulizer, and is opened for replacing the container. A securing device having locking portions which are forced apart is provided to prevent reconnection of an already used container. The nebulizer has an indicator for showing the current container number and/or symbols indicating the need container replacement. The indicator is driven by the force of an internal spring. The indicator member also controls a lock of the container for locking the container against further actuation. The lock is reset after container replacement.

Anesthetic Inhalation Aid Device and Attachment Used for the Same

An inhalation mask, an artificial nose unit, an anesthetic gas concentration detector, an extension tube, an anesthesia attachment, and an elastic bag are in communicative connection in sequence. The elastic bag has a mixing chamber formed therein and has an anesthetic inlet, an air inlet, and an outlet port each formed at the boundary to the exterior. The anesthesia attachment includes a hollow structure and an evaporation injector syringe. The outlet port of the elastic bag is in communicative connection with the hollow structure through its opening, and the evaporation injector syringe tightly mates with the interior of another opening. The anesthetic introduced into the mixing chamber is vaporized and then mixed with air introduced from the air inlet into mixed gas. The mixed gas is supplied from the outlet port to the inhalation mask by compressing the elastic bag or other procedures.

Nozzle and inhaler and method for producing a nozzle

A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed. The nozzle comprises two holes formed in a flat plate. Then, the plate is deformed such that the axes of the holes intersect so that jets of fluids generated by the holes impinge with each other.

INTRASITE ADMINISTRATION AND DOSING METHODS AND PHARMACEUTICALS FOR USE THEREIN

A new method of targeted drug administration to wounds (surgical or traumatic), intrasite (IS), offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing IS medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large IS doses increase risk of toxicity from impurities allowed in drugs given by other routes. Methods are presented for ultrapurification, particularly of endotoxins. Methods are presented for sterile delivery to the wound, to prevent aerosolization, and to homogenize application. Pharmacodynamic parameters make certain drugs advantageous as IS agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an IS medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful IS pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration methods. 159-. (canceled)60. A method of selecting a therapeutic agent for use in intrasite administration , comprisingproviding one or more therapeutic agents, andselecting a therapeutic agent that has one or more characteristics selected from the group consisting of low oral bioavailability, high protein-binding affinity, low or no toxicity to wound tissue, antimicrobial activity, low rate of induction of microbe resistance, low or no rate of absorption through wound tissue, and activity against biofilm.61. The method of claim 60 , wherein the therapeutic agent is antimicrobial.62. The method of claim 60 , wherein the therapeutic agent is antithrombotic or prothrombotic.63. The method of claim 60 , wherein the therapeutic agent is antinecrotic or antiapoptotic.64. The method of claim 60 , wherein the ...

Intrasite administration and dosing methods and pharmaceuticals for use therein

A new method of targeted drug administration to wounds (surgical or traumatic), intrasite (IS), offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing IS medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large IS doses increase risk of toxicity from impurities allowed in drugs given by other routes. Methods are presented for ultrapurification, particularly of endotoxins. Methods are presented for sterile delivery to the wound, to prevent aerosolization, and to homogenize application. Pharmacodynamic parameters make certain drugs advantageous as IS agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an IS medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful IS pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration methods.

CALMING COMPOSITION

Certain embodiments of the present invention relate to compositions for calming and de-stressing animals. In particular, but not exclusively, certain embodiments of the present invention relate to compositions comprising valerian oil. 144-. (canceled)45. A composition for reducing one or more symptoms of stress of an animal or human , the composition comprising:a) valerian oil;b) one or more further essential oils;c) water;d) at least one preservative;e) at least one solvent;f) at least one pH stabiliser; andg) at least one emulsifier.46. The composition according to claim 45 , wherein:(i) the composition comprises valerian oil in an amount of between about 0.1 to about 0.5% v/v of the composition;(ii) the composition comprises water in an amount of at least 80% v/v of the composition;(iii) the one or more further essential oils comprises one or more of vetiver oil and/or basil oil and/or clary sage oil;(iv) the composition comprises one or more further essentials oil in an amount of between about 0.05% to about 1% v/v of the composition;(v) the composition comprises the at least one emulsifier in an amount of between about 1% and about 9% v/v of the composition;(vi) the composition comprises the at least one solvent in an amount of between about 1% and about 9% v/v of the composition;(vii) the composition comprises the at least one preservative in an amount of between about 0.1% and about 0.5% v/v of the composition; and/or(viii) the composition comprises the at least one preservative in an amount of between about 0.005% and about 0.06% v/v of the composition.47. The composition according to claim 45 , wherein:(i) the composition comprises a ratio of about 1:331 of valerian oil to water;(ii) wherein the composition comprises a ratio of about 1:1.5 of valerian oil to the one or more further essential oil;(iii) the composition comprises a ratio of about 1:18.5 of valerian oil to emulsifier;(iv) the composition comprises a ratio of about 1:18.5 of valerian oil to ...

METHODS AND DEVICES TO PREVENT PREMATURE BIRTH

Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system. 1. A method for delivering a microbial barrier to a vaginal portion of a cervix of a pregnant woman , the method comprising:visualizing the distal portion of the vagina of the pregnant woman; andapplying a barrier material over cervical epithelial tissue on the vaginal portion of the cervix while preventing the barrier material from completely obstructing a path of egress of biological materials from the uterus into the vagina.2. The method of claim 1 , wherein the barrier is applied without inserting an implant into the cervical canal.3. The method of claim 1 , wherein the barrier material is prepared by combining two or more previously separated liquid or gel-like components.4. The method of claim 3 , wherein the combined previously separated liquid or gel-like components are delivered over the cervical epithelial tissue prior to a full transformation of the combined components into a solid or substantially solid state.5. The method of claim 1 , wherein a surface of the vaginal portion of the cervix is prepared for delivery of the microbial barrier by one or more of: drying the surface claim 1 , removing bacteria from the surface claim 1 , removing mucus or fluids from the surface claim 1 , disinfecting the surface claim 1 , or applying an agent to the surface that promotes adhesion of the coating material to the surface.6. The method of claim 1 , wherein the delivered barrier material occupies a site wholly outside of the uterus and cervical canal.7. The method of claim 1 , wherein the delivered barrier material is configured not to prevent or substantially impede the evacuation of chorioamniotic fluids in the event of rupture of chorioamniotic membranes.8. The method of claim 1 , wherein the microbial barrier is delivered without disrupting a cervical mucus plug within the cervical canal.9. A method for delivering a ...

DELIVERY DEVICES AND METHODS

Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed. 1. A device comprising:a flow chamber including an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber;a formation portion of the flow chamber in which a suspension of the material is formed;a collection portion of the flow chamber that directs the suspension toward the outlet port, wherein an amount of the material collects in the collection portion adjacent the outlet port; anda pusher operable to move the amount of material through the outlet port.2. The device of claim 1 , wherein the outlet port is in communication with an exit lumen claim 1 , and an end of the pusher is movable through a portion of the exit lumen.3. The device of claim 1 , wherein the formation portion includes a semi-spherical surface defining a volume in which the fluid flow expands.4. The device of claim 3 , wherein the formation portion includes a semi-frustoconical surface that funnels the suspension towards the collection portion.5. The device of claim 1 , wherein the pusher is biased toward or away from the outlet port by a resilient element.6. The device of claim 5 , further comprising a stopper movable between a first position to compress the ...

NASAL DELIVERY ASSEMBLY FOR A FLUID PRODUCT AND METHOD FOR ACTUATING THE ASSEMBLY

A nasal fluid dispenser assembly () having a first reservoir () of fluid, a metering pump () mounted on the first reservoir () and including a piston (); a compressed gas flow generator system; a nasal endpiece () having a connection portion () fastened to the outlets of the pump and valve (), a fluid chamber () that receives the dose of fluid and the flow of compressed gas, and a nasal insertion element ( that extends longitudinally along an axis (B) and contains a dispenser channel () connected to the fluid chamber and has a dispenser orifice (). The axis (B) forms an angle (α) relative to the longitudinal axis (A). The dose of fluid is dispensed into the fluid chamber and then expelled under pressure by the flow of compressed gas out from the fluid chamber through the dispenser channel () the dispenser orifice (). 1. A nasal fluid dispenser assembly , characterized in that it comprises:a first reservoir containing a plurality of doses of a fluid, a metering pump being mounted on said first reservoir so as to dispense a dose of said fluid each time said dispenser assembly is actuated, said metering pump including a piston that is movable axially along a longitudinal axis (A);a compressed gas flow generator system for dispensing a flow of compressed gas each time said dispenser assembly is actuated;a nasal endpiece comprising a connection portion and a nasal insertion element, said connection portion being fastened at one end to the outlet of said metering pump, and at the other end to the outlet of said compressed gas flow generator system, said connection portion including a fluid chamber that, each time said dispenser assembly is actuated, receives the dose of fluid dispensed by said metering pump, and the flow of compressed gas dispensed by said compressed gas flow generator system, said nasal insertion element comprising an elongate body for inserting into a user's nostril, said elongate body extending longitudinally along an axis and containing a dispenser ...

APPLICATOR

An applicator is inserted into a living body and applies mixed solution to a region in the living body. The applicator includes a nozzle including an elongated nozzle main body to which gas and a plurality of kinds of liquids are supplied and a nozzle head at a distal end of the nozzle main body and configured to jet A mixed solution of the gas and the liquids supplied to the nozzle main body, and a sheath in which the nozzle main body is fitted for relative movement along a longitudinal axial direction of the nozzle main body. At least two crushed portions are provided contiguously to each other at a proximal end portion of the nozzle main body at the opposite side to the nozzle head such that deformation directions thereof with respect to an axial line of the nozzle main body are different from each other. 1. An applicator configured to be positioned in a living body , the applicator comprising:a sheath possessing a lumen, and open distal and proximal ends communicating with the lumen of the sheath, the sheath also possessing an inner face surrounding the lumen;a nozzle including an elongated nozzle main body possessing proximal and distal ends, a spray head connectable to different kinds of liquids to be conveyed through the nozzle main body and mixed with one another, and a nozzle head, the spray head being fixed to the proximal end of the nozzle main body so that the nozzle main body and the spray head move together as a unit, the nozzle head being fixed to the distal end of the nozzle main body so that the nozzle main body and the nozzle head move together as a unit, the nozzle head possessing a distal end at which is located an opening through which the liquids mixed together as a mixed solution are ejected together with a gas, the nozzle main body being axially movably positioned in the lumen of the sheath;the applicator being insertable into a living body to apply the mixed solution to a region in the living body;the nozzle main body including an axially ...

A DEVICE FOR APPLYING AN OPHTHALMIC FLUID

A device for dispensing a mist of an ophthalmic fluid includes a discharge opening for said mist, a mixing chamber communicating with said discharge opening, an air chamber holding a volume of air, a first drive operable to expel air from said air chamber, a fluid chamber for holding a volume of the fluid to be dispensed and communicating with said mixing chamber, a second drive for delivering a predetermined dose of said fluid to said fluid chamber, said air chamber communicating with said fluid chamber and with said mixing chamber, said device establishing one flow of expelled air flowing into said fluid chamber, so as to force liquid from said fluid chamber into said mixing chamber, and another flow of said expelled air flowing past said fluid chamber into said mixing chamber. 1. A device for dispensing a mist of an ophthalmic liquid fluid , comprising: a mixing chamber communicating with said discharge opening,', 'an air chamber for holding a volume of air,', 'a first drive operable to expel air from said air chamber,', 'a fluid chamber for holding a volume of the fluid to be dispensed and communicating with said mixing chamber,', 'characterised in', 'a second drive for delivering a predetermined dose of said fluid to said fluid chamber and communicating with or being configured for communicating with a supply of said fluid, such as a container,', 'said air chamber communicating with said fluid chamber and separately with said mixing chamber,', 'said device being configured for establishing one flow of said expelled air flowing into said fluid chamber, so as to force said fluid from said fluid chamber into said mixing chamber, and another flow of said expelled air flowing past said fluid chamber into said mixing chamber, for assisted atomizing of said fluid by said other flow of air striking said fluid forced into said mixing chamber., 'a discharge opening for said mist,'}2. The device according to claim 1 , including a container for said fluid.3. The device ...

Monodose Nasal Drug Delivery System

A delivery device for delivery of medicament to a user including a container defining a reservoir storing the medicament, a body in which the container is received, a spray nozzle arranged on one of the body and the container for receiving medicament expelled from the container, and a pusher actuatable for pushing the medicament from the container reservoir through the nozzle, said pusher being moveable from a rest position to a fully activated position relative to said body in response to an actuating force. The assembly is particularly applicable to nasal syringes where it is desirable to deliver the medicament in the form of a spray. 1. A delivery device for delivery of a medicament to a user , comprising:a tubular reservoir for containing the medicament;a body sized and shaped to receive at least a part of the reservoir;a spray nozzle arranged on one of the body and the reservoir, the nozzle providing a path for the medicament to be expelled from the reservoir;a pusher defining a longitudinal axis and comprising a thumb pad and at least one flexible arm extending from the thumb pad, the pusher being movable relative to the body from a rest position to a fully activated position in response to an actuating force, wherein movement from the rest position to the fully activated position causes the medicament to be expelled from the reservoir through the nozzle;at least one slot extending through an exterior of the body in which the at least one flexible arm of the pusher is received; anda dose control arrangement for ensuring that the medicament is delivered by the device, the dose control arrangement comprising:a track defined on the body and comprising an interlock defining an interlock surface; anda track follower defined on the at least one flexible arm of the pusher,wherein the interlock releasably receives and retains the track follower to hold the pusher in the rest position until a user applies an actuating force to the pusher that meets or exceeds a ...

NOZZLE FIXTURE FOR AN INHALATION DEVICE

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a fixture for a nebulizing nozzle to be used in such an inhalation device. A nozzle fixing assembly () for an inhalation device, comprising an elastically deformable seal element (), having a continuous opening () capable of receiving a nozzle body (), said seal element () and said nozzle body () each having a high pressure side (A, A) and an outlet side (B, B); and a pressure element () with a high pressure side (A), said side being arranged to face the high pressure side (A) of the seal element (); wherein (i) the high pressure side (A) of the seal element () is substantially flat, and (ii) the high pressure side (A) of the pressure element () is chamfered in a way that, in the assembled state, the distance between these high pressure sides (A, A) is higher in a central region (C) than in a peripheral region (P). 2. Inhaler comprising a nozzle fixing assembly according to claim 1 , additionally comprising the nozzle body claim 1 , wherein the nozzle body is inserted in the continuous opening.3. Inhaler comprising a nozzle fixing assembly according to claim 1 , further comprising a holder with a recess inside which the seal element and the pressure element are arranged claim 1 , the holder comprising (i) a low pressure surface which is claim 1 , in the assembled state claim 1 , in contact with the outlet side of the nozzle body claim 1 , and (ii) an inside contour matching an outside contour of the seal element claim 1 , and (iii) a high pressure end claim 1 , containing at least the high pressure side of the pressure element.4. Inhaler comprising a nozzle fixing assembly according to claim 1 , wherein claim 1 , in the assembled state claim 1 , the high pressure side of the pressure element is at least partially in physical contact with the high pressure side of the seal element.5. Inhaler comprising a nozzle fixing assembly according to claim 1 , wherein ...

INTRASITE ADMINISTRATION AND DOSING METHODS AND PHARMACEUTICALS FOR USE THEREIN

A new method of targeted drug administration to wounds (surgical or traumatic), intrasite (IS), offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing IS medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large IS doses increase risk of toxicity from impurities allowed in drugs given by other routes. Methods are presented for ultrapurification, particularly of endotoxins. Methods are presented for sterile delivery to the wound, to prevent aerosolization, and to homogenize application. Pharmacodynamic parameters make certain drugs advantageous as IS agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an IS medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful IS pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration methods. 182-. (canceled)83. A method of reducing aerosolization of a lyophilized pharmaceutical composition having at least one low bioavailability therapeutic agent , the method comprisingwetting the lyophilized pharmaceutical composition having at least one low bioavailability therapeutic agent, wherein the wetting results in a paste but does not fully dissolve the pharmaceutical composition;dissolving the paste into a solution;emulsifying the solution with a metabolizable emulsifying agent; andcreating a gel comprising the emulsified solution, an aqueous solvent, and a metabolizable gelling agent;wherein the gel is resistant to aerosolization.84. The method of claim 83 , wherein the emulsifying agent is lecithin.85. The method of claim 83 , wherein the gelling agent is non-proteinaceous.86. The ...

INTRASITE ADMINISTRATION AND DOSING METHODS AND PHARMACEUTICALS FOR USE THEREIN

A new method of targeted drug administration to wounds (surgical or traumatic), intrasite (IS), offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing IS medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large IS doses increase risk of toxicity from impurities allowed in drugs given by other routes. Methods are presented for ultrapurification, particularly of endotoxins. Methods are presented for sterile delivery to the wound, to prevent aerosolization, and to homogenize application. Pharmacodynamic parameters make certain drugs advantageous as IS agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an IS medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful IS pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration methods. 188-. (canceled)89. A wound treating device , comprisinga dispensing pathway;a medication receptacle fluidically connected to the dispensing pathway and configured to receive a container of medication;a dosing mechanism comprising a dosing meter fluidically connected to the medication receptacle and configured to release a pre-set amount of medication into the dispensing pathway;a propellant receptacle fluidically connected to the dispensing pathway and configured to receive a container of propellant;a trigger configured to cause propellant to be released from the propellant container into the dispensing pathway;a solvent receptacle fluidically connected to the dispensing pathway;a mixing venturi nozzle, configured to mix solvent and medication to achieve particles of at least 10 μm when the ...

Nebulizer and Cartridge

A nebulizer for nebulizing a fluid from a cartridge and a cartridge for such a nebulizer is proposed. The cartridge comprises a container containing the fluid to be nebulized and is fluidically connected to the nebulizer by inserting a connecting element of the nebulizer for conveying the fluid out of the container. The cartridge is preferably adapted to sealingly receive the connecting element and can optionally comprise a membrane or sealing wall which seals the cartridge initially and is piercable or breakable by the connecting element upon insertion. The cartridge can further comprise an at least partially flexible and/or bendable tube for conveying the fluid out of the container. The tube is preferably wettable with the fluid and/or comprises an at least partially hydrophilic and/or polar surface. Further, the tube can at least partially be shaped as a helix. When the cartridge is connected to the nebulizer, the tube and the connecting element preferably form a continuous capillary and/or an at least essentially constant flow area. 131223. A cartridge () for a nebulizer () for nebulizing of a fluid () , the fluid () being a pharmaceutical composition/formulation and/or a liquid medicament , the cartridge () comprising:{'b': 4', '2, 'a container () containing the fluid () to be nebulized,'}{'b': 25', '2', '4', '25, 'a tube () for conveying the fluid () out of the container (), the tube () being at least partially flexible and/or bendable, and'}{'b': 7', '9', '4', '1', '10, 'a closure () with a connection port () for fluidically and/or sealingly connecting the container () to the nebulizer () or a delivery mechanism () thereof,'}{'b': 25', '7', '9, 'in particular the tube () being mechanically and/or fluidically connected—preferably directly or indirectly—to the closure () or connection port (), wherein at least one of{'b': 25', '2', '25', '2, 'the tube () is at least partially wettable with the fluid () in such a way that the tube () is at least partially ...

MEDIA DISPENSER

Dispenser for the delivery of liquid media, having a base unit and a delivery head with a delivery opening. The delivery head includes a first portion which includes a fastening device by means of which the first portion is fastened or fixed in position with respect to a media storage unit on the base unit, and which includes the delivery opening. The delivery head includes a second portion realized so as to be movable in relation to the first portion and includes an actuating handle which is operatively coupled with the coupling piece such that a displacement of the actuating handle in relation to the first portion leads to a displacement of the coupling piece in relation to the first part portion. 1. A dispenser for the delivery of media , in particular liquids , said dispenser having a media storage unit which is realized for storing a medium and', 'an outlet connecting piece which is movable in relation to the media storage unit in order, as a result, to cause a delivery of medium in the direction of a delivery head through the outlet connecting piece, and', 'a delivery head which includes:', 'a delivery opening through which the medium is able to escape into a surrounding atmosphere,', 'a delivery channel, at the first end of which is provided a coupling piece for coupling to the outlet connecting piece and the second end of which is connected to the delivery opening,, 'a base unit which includeswhereinthe delivery headcomprises a first part portion which comprises a fastening device, by means of which it is fastened fixed in position with respect to the media storage unit on the base unit and which includes the delivery opening andcomprises a second part portion which is realized so as to be movable in relation to the first part portion and comprises an actuating handle which is operatively coupled with the coupling piece in such a manner that a displacement of the actuating handle in relation to the first part portion leads to a displacement of the coupling ...

RESERVOIR FOR AN INHALATION DEVICE

The invention relates to the field of inhalation devices for medically active liquids. In particular, the invention relates to a cartridge containing said liquid for such an inhalation devices. A cartridge () for the storage of a medically active liquid (L) and for supply of the same to a pumping unit of an inhalation device comprises an outer container () enclosing a collapsible inner bag (), and a cap () which is capable of closing the container (), the cap () further providing an openable access opening () to the inner bag (), wherein further, the container () of the cartridge () has a pressure compensation opening (), and wherein said pressure compensation opening () is located in a region () which is covered by the cap (). In a method for providing a pressure compensation to the collapsible inner bag-containing interior of the outer container () of a cartridge (), initially, before the cartridge () is connected to a holder (), the pressure compensation opening () is closed, and subsequently, when the cartridge () is connected to the holder (), by way of mechanically deforming (i) a pressure compensation opening comprising region of the outer container () and/or (ii) a compensation opening covering region of the cap (), an air gap () is provided which allows for a pressure equalization of the bag-containing interior with the ambient pressure. 2. Cartridge according to claim 1 , wherein claim 1 , in a state when the cartridge is disconnected from the holder claim 1 , the at least one pressure compensation opening is covered by the cap claim 1 , while in a state when the cartridge is connected to the holder claim 1 , said pressure compensation opening is open.3. Cartridge according to claim 2 , wherein claim 2 , in a state when the cartridge is disconnected from the holder claim 2 , the at least one pressure compensation opening is covered airtight by the cap.4. Cartridge according to claim 1 , wherein the cap and/or at least a cap connection region of the outer ...

DEVICE FOR NASAL DELIVERY OF FLUID PRODUCT

A nasal fluid dispenser device comprising: a body () comprising a hollow sleeve () and a top surface (); and an actuator member () that is mounted to slide in said body () so as to actuate the device; the device further comprising two nasal extensions (), at least one of which forms a dispenser head provided with a respective dispenser orifice (), said nasal extensions extending from said top surface (), each dispenser head being connected, during actuation, to a respective reservoir () that is arranged in said body (), said two nasal extensions () forming an angle lying in the range 30° to 60° relative to a longitudinal central axis (A) of said body (10). 1101115401020302131155010203010. A nasal fluid dispenser device comprising: a body () comprising a hollow sleeve () and a top surface (); and an actuator member () that is mounted to slide in said body () so as to actuate the device; the device being characterized in that it further comprises two nasal extensions ( , ) , at least one of which forms a dispenser head provided with a respective dispenser orifice ( , ) , said nasal extensions extending from said top surface () , each dispenser head being connected , during actuation , to a respective reservoir () that is arranged in said body () , said two nasal extensions ( , ) forming an angle lying in the range 30° to 60° relative to a longitudinal central axis (A) of said body ().22030. A device according to claim 1 , wherein said two nasal extensions ( claim 1 , ) are parallel.32030. A device according to claim 1 , wherein said two nasal extensions ( claim 1 , ) form an angle lying in the range 40° to 50° claim 1 , in particular about 45°.42030. A device according to claim 1 , wherein said two nasal extensions ( claim 1 , ) have an insertion depth lying in the range 5 mm to 15 mm claim 1 , in particular about 10 mm.550. A device according to claim 1 , wherein each reservoir () contains a single dose of fluid for dispensing in a single actuation.6505125351051. A ...

NASAL DELIVERY DEVICES

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece () through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece () for fitting to a nostril of a subject, the nosepiece including a nozzle () through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit () for delivering substance through the nozzle of the nosepiece. 138-. (canceled)39. A nasal delivery device for delivering a substance to a nasal airway of a subject , comprising:a housing;a mouthpiece through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject;a nosepiece for fitting to a nostril of the subject, wherein the nosepiece includes a nozzle through which the substance is in use delivered as an aerosol spray into the nasal airway of the subject;a manually-actuatable substance supply unit for delivering the substance through the nozzle, wherein the substance supply unit comprises a substance-containing chamber which contains the substance and extends from an aperture in the housing as an actuating part of the substance supply unit, and a mechanical delivery pump which is actuatable by depression of the substance-containing chamber to deliver the substance from the nozzle; anda valve assembly which is fluidly connected to the mouthpiece and the nosepiece and operable between a closed configuration substantially blocking a fluid communication path between the mouthpiece and the nosepiece and an open configuration permitting a flow of fluid through the fluid communication path between the mouthpiece and the nosepiece, wherein the substance-containing chamber is coupled to the valve assembly and configured to provide for simultaneous actuation of the mechanical delivery pump and opening of the valve assembly to deliver an air flow through the fluid communication path ...

Nasal drug delivery system

Devices, systems, and methods for treating chronic rhinosinutisits (CRS) are described herein. The devices can have a guide member defining at least one lumen therethrough. A drug delivery component is advanced through the lumen to deliver a substance to the sino-nasal cavity of a patient. Once the drug delivery component is positioned at the desired area in the sino-nasal cavity, a user actuates the system to deliver the substance to the target area. Actuation of the system delivers the substance to the middle meatus, osteo-meatal complex, or other areas within the sino-nasal cavity of the patient.

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 122.-. (canceled)23. A method of preventing the use of naloxone to titrate opioid receptor occupancy , the method comprising:delivering a spray from a pre-primed device into a nostril of a patientwherein the spray delivers a 25-200 μL spray of a pharmaceutical solution comprising between about 4 mg and about 10 mg naloxone hydrochloride of a hydrate thereof, an isotonicity agent, and between about 0.005% and about 0.15% (w/v) of benzalkonium chloride.24. The method of claim 23 , wherein the spray consists of a mist in which no more than about 10% of the droplets have a diameter less than 10 μm.25. The method of claim 24 , wherein the pharmaceutical solution is delivered in a round spray plume with an ovality ratio less than about 2.0 when measured at 3 cm.26. The method of claim 25 , wherein the isotonicity agent is present in an amount between about 0.2% and about 1.2% (w/v).27. (canceled)28. The method of claim 26 , wherein the pharmaceutical solution further comprises between about 0.1% and about 0.5% (w/v) of a stabilizing agent and an amount of an acid sufficient to achieve a pH between about 3.5 and about 5.5.29. The method of claim 28 , wherein:the isotonicity agent is sodium chloride;the stabilizing agent is disodium edetate; andthe acid is hydrochloric acid.30. The method of claim 29 , wherein the pharmaceutical solution comprises:about 4.4% (w/v) naloxone hydrochloride dihydrate;about 0.74% (w/v) sodium chloride;about 0.01% (w/v) benzalkonium chloride; andabout 0.2% (w/v) disodium edetate.31. The method of claim 30 , wherein the device has a single reservoir containing approximately 125 μL of the pharmaceutical solution.32. The method of claim 23 , wherein the spray delivers about 4 mg ...

Method and Apparatus for the Production of Microscale Bubbles by Depressurization Cavitation

A method and apparatus that enables the production of micron-scale free-standing bubbles made of liquids containing surfactants are provided. The method and apparatus of the invention overcomes the limitations of conventional bubble forming techniques by using a controlled cavitation process in a liquid media. 120-. (canceled)22. The method of claim 21 , wherein the solution contains a surfactant selected from the group consisting of soap claim 21 , detergent and sodium lauryl sulfate.23. The method of claim 21 , wherein the internal pressure is at least 2000 psi.24. The method of claim 21 , wherein the local pressure is 1 atm.25. The method of claim 21 , wherein the internal pressure is at least 2200 psi claim 21 , the local pressure is 1 atm claim 21 , the atomizing misting nozzle has an orifice opening size of 1 mm or less claim 21 , and the bubbles are on the order of about 10 microns in size and have a lifetime of at least 10 minutes.26. The method of claim 21 , wherein the step of pressurizing is accomplished via one of either an air compressor or a reciprocating piston.27. The method of claim 21 , wherein the atomizing misting nozzle has an orifice opening size of 1 mm or less.28. The method of claim 21 , wherein the atomizing misting nozzle has an orifice opening size of 0.25 mm or less.29. The method of claim 21 , wherein the bubbles have a lifetime of at least 10 minutes.30. The method of claim 21 , wherein the solution has a ratio of surfactant to water of at least 1:2.33. The apparatus of claim 32 , wherein the solution contains a surfactant selected from the group consisting of soap claim 32 , detergent and sodium lauryl sulfate.34. The apparatus of claim 32 , wherein the internal pressure is at least 2000 psi.35. The apparatus of claim 32 , wherein the local pressure of the external environment is 1 atm.36. The method of claim 32 , wherein the internal pressure is at least 2200 psi claim 32 , the local pressure of the external environment is 1 atm ...

A MOBILE INHALER AND A CONTAINER FOR USING THEREWITH

A mobile inhaler is provided and a container for using therewith. The mobile inhaler comprises: a mouthpiece comprising at least one inhaling opening; a body element connected to the mouthpiece and comprising a housing for holding a DC power source; a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; a nebulizer comprising an ultrasonic vibrator and a mesh, wherein the ultrasonic vibrator is activated by the AC voltage, and wherein the nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from the mouthpiece; and an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from the enclosure to the nebulizer. 1. A mobile inhaler , comprising:a mouthpiece comprising at least one inhaling opening;a body element connected to the mouthpiece and comprising a housing for holding a DC power source;a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; 'an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from said enclosure to the nebulizer.', 'a nebulizer comprising an ultrasonic vibrator and a mesh, wherein said ultrasonic vibrator is activated by said AC voltage, and wherein said nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from said mouthpiece; and'}2. The mobile inhaler of claim 1 , wherein the enclosure includes a mechanism to enable fluid transfer from said enclosure to the nebulizer claim 1 , irrespective of a spatial angle at which it is being hand-held.3. The mobile inhaler of claim 1 , wherein said liquid is in a contact with a wick.4. ...

Pharmaceutically Acceptable Composition Comprising Dilute Sodium Hypochlorite Solution

A pharmaceutically acceptable composition comprising dilute stabilized sodium hypochlorite solution and an indicator to show that the dilute stabilized sodium hypochlorite solution is fresh and active. 1. A pharmaceutically acceptable composition comprising dilute stabilized sodium hypochlorite solution and an indicator to show that the dilute stabilized sodium hypochlorite solution is fresh and active.2. A pharmaceutically acceptable composition according to claim 1 , wherein the sodium hypochlorite is in a concentration range of 0.025%-0.2%.3. A pharmaceutically acceptable composition according to claim 1 , wherein the sodium hypochlorite is in a concentration range of 0.05%-0.1%.4. A pharmaceutically acceptable composition according to claim 1 , wherein the dilute stabilized sodium hypochlorite solution further comprises sodium chloride.5. A pharmaceutically acceptable composition according to claim 1 , wherein the dilute stabilized sodium hypochlorite solution further comprises sodium chloride in a concentration range of 0.41%-1.65%.6. A pharmaceutically acceptable composition according claim 1 , wherein said indicator is a dye or a flavor or a combination thereof.7. A pharmaceutically acceptable composition according to claim 1 , wherein said indicator is a dye or a flavor or a combination thereof selected such that it shows that said dilute stabilized sodium hypochlorite solution is fresh and active by means of a color change and/or a change in taste within a period of from 45 to 60 minutes after said dilute stabilized sodium hypochlorite solution is prepared.8. A pharmaceutically acceptable composition according to wherein said indicator is a dye selected from the group consisting of azafloxin claim 1 , basic blue (nil blue sulphate) claim 1 , bismarck brown claim 1 , basic red (rhodamine 6G) claim 1 , bengal red claim 1 , brilliant crysyl blue claim 1 , eosin claim 1 , fluorescein claim 1 , gentian violet claim 1 , indocyanine green claim 1 , janus green ...

INTRANASAL NALTREXONE

A stable transmucosal composition consisting essentially of naltrexone hydrochloride in water is provided. The composition is surprisingly stable at room temperature and can be used for simple, rapid and effective opioid overdose rescue. 1. A pharmaceutical composition consisting essentially of naltrexone hydrochloride and water , the composition capable of maintaining at least about 90% of said naltrexone hydrochloride in undegraded form after storage for 180 days at room temperature.2. The composition of claim 1 , wherein the composition is capable of maintaining at least about 95% of said naltrexone in undegraded form after storage for 180 days at room temperature.3. The composition of claim 1 , wherein the naltrexone hydrochloride is present in the composition in an amount between about 0.001 mg/mL and 20 mg/mL.4. The composition of claim 3 , wherein the naltrexone hydrochloride is present in the composition in an amount between 0.5 mg/mL and 5 mg/mL.5. The composition of claim 1 , wherein the composition consists of naltrexone hydrochloride and water.6. The composition of claim 1 , wherein the composition does not contain a preservative.7. The composition of wherein the composition does not contain a buffering agent.8. The composition of wherein the composition does not contain a tonicity agent.9. The composition of claim 1 , wherein the composition does not contain a pH adjusting agent.10. The composition of claim 1 , wherein the composition consists of naltrexone hydrochloride dissolved in water at a concentration in the range of from about 0.001 mg/mL to about 20 mg/mL in sterile water or water for injection.11. A method for treating a patient suffering from claim 1 , or suspected of suffering from claim 1 , an opioid agonist overdose claim 1 , the method comprisingadministering transmucosally to the patient a first dose of a pharmaceutical composition consisting essentially of a pharmaceutically effective dose of naltrexone hydrochloride and water; wherein ...

DELIVERY DEVICES FOR NASOPHARYNGEAL MUCOSA TARGETS

A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue has a shaft, a porous pad of compliant material coupled to the shaft near the distal end, and a drug reservoir. The porous pad is configured to expand from a contracted configuration to an expanded configuration. The expanded configuration is adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration has a size suitable for introduction into the nasal cavity. The drug reservoir holds a therapeutic agent and is at least partially covered by the porous pad. The drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes, and has a wall with a plurality of channels fluidly coupled with the porous pad. 1. A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue , said system comprising:a shaft having a proximal end and a distal end;a porous pad of compliant material coupled to the shaft near the distal end, wherein the porous pad is configured to expand from a contracted configuration to an expanded configuration, the expanded configuration being adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration having a size suitable for introduction into the nasal cavity; anda drug reservoir holding a therapeutic agent, the drug reservoir being at least partially covered by the porous pad, the drug reservoir having a wall with a plurality of channels fluidly coupled with the porous pad.2. The system of claim 1 , wherein the drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes.3. The system of claim 1 , wherein the elongate central member comprises an elongate shaft.4. The system of claim 3 , wherein the elongate shaft comprises a central lumen extending therethrough.5. The system of claim 3 , wherein the elongate shaft ...

MOBILE INHALER AND A CONTAINER FOR USING THEREWITH

A mobile inhaler is provided and a container for using therewith. The mobile inhaler comprises: a mouthpiece comprising at least one inhaling opening; a body element connected to the mouthpiece and comprising a housing for holding a DC power source; a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; a nebulizer comprising an ultrasonic vibrator and a mesh, wherein the ultrasonic vibrator is activated by the AC voltage, and wherein the nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from the mouthpiece; and an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from the enclosure to the nebulizer. 1. A mobile inhaler , comprising:a mouthpiece comprising at least one inhaling opening;a body element connected to the mouthpiece and comprising a housing for holding a DC power source;a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage;a nebulizer comprising an ultrasonic vibrator and a mesh, wherein said ultrasonic vibrator is activated by said AC voltage, and wherein said nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from said mouthpiece; andan enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from said enclosure to the nebulizer.2. The mobile inhaler of claim 1 , wherein the enclosure includes a mechanism to enable fluid transfer from said enclosure to the nebulizer claim 1 , irrespective of a spatial angle at which it is being hand-held.3. The mobile inhaler of claim 1 , wherein said liquid is in a contact with a wick and wherein ...

ATOMISER, IN PARTICULAR INHALER, FOR ATOMISING A LIQUID ACTIVE AGENT TO FORM AN AEROSOL AND A CORRESPONDING METHOD

The invention relates to an atomiser, in particular an inhaler, for atomising a liquid active agent to form an aerosol, having an active agent reservoir (), an atomiser nozzle () and a pump arrangement (), wherein a suction side () of the pump arrangement () leads into the active agent reservoir () and a pressure side () of the pump arrangement () leads into the atomiser nozzle (), and wherein the pump arrangement () has a plunger () that can be adjusted in a cylinder () in the axial direction (x) of the cylinder (), characterised in that the plunger () is supported in portions along its outer circumference () in a form-fitting manner on an inner wall () of the cylinder () and a gap () is formed in portions between the inner wall () of the cylinder () and the plunger (), wherein the plunger () is rotatably mounted around its longitudinal axis (x) in the cylinder () and can be adjusted between a suction position, in which a pump chamber () of the pump arrangement () is connected to the suction side () via the gap (), and a pump position, in which the plunger () closes the suction side (). A corresponding method is also described. 1. An atomiser , in particular an inhaler , for atomising a liquid active agent to form an aerosol , having an active agent reservoir , an atomising nozzle and a pump arrangement , wherein a suction side of the pump arrangement opens out into the active agent reservoir and a pressure side of the pump arrangement into the atomising nozzle , and wherein the pump arrangement has a piston that can be adjusted in a cylinder in an axial direction of the cylinder , wherein the piston abuts proportionately on an inner wall of the cylinder in a positive fitting manner along its outer periphery , and a gap is formed proportionately between the inner wall of the cylinder and the piston , wherein the piston is rotatably mounted around its longitudinal axis in the cylinder and can be adjusted between a suction position , in which a pump chamber of the ...

TENSIONING ARRANGEMENT FOR AEROSOL DISPENSER AND AEROSOL DISPENSER

A tensioning arrangement for an aerosol dispenser is presented where the tensioning arrangement has a conveying tube; an elastic member arranged to store mechanical energy from a substantially axial tensioning movement of the conveying tube; a rotatable member; a transmission mechanism configured to transmit a tensioning rotation of the rotatable member to the tensioning movement of the conveying tube, wherein the transmission mechanism has a cam profile and a cam follower arranged to follow the cam profile, wherein the cam profile has at least one priming structure; and wherein the tensioning arrangement is configured such that the conveying tube makes a temporary priming movement towards an initial position when the cam follower passes each priming structure during the tensioning movement of the conveying tube by means of the tensioning rotation of the rotatable member. An aerosol dispenser is also provided. 115-. (canceled)16. A tensioning arrangement for an aerosol dispenser , the tensioning arrangement comprising:a conveying tube for conveying liquid from a container to a dose chamber;an elastic member arranged to store mechanical energy from a substantially axial tensioning movement of the conveying tube from an initial position to a tensioning position;a rotatable member;a transmission mechanism configured to transmit a tensioning rotation of the rotatable member to the tensioning movement of the conveying tube;wherein the transmission mechanism comprises a cam profile and a cam follower arranged to follow the cam profile;wherein the cam profile comprises at least one priming structure; andwherein the tensioning arrangement is configured such that the conveying tube makes a temporary priming movement towards the initial position when the cam follower passes each priming structure during the tensioning movement of the conveying tube by means of the tensioning rotation of the rotatable member.17. The tensioning arrangement according to claim 16 , wherein one of ...

ARRANGEMENT FOR AEROSOL DISPENSER, AEROSOL DISPENSER AND METHOD

An arrangement for activating an aerosol dispenser having a conveying tube for conveying a liquid; a movable holding member holding the conveying tube; a rotatable base; and a container chamber between the holding member and the base, wherein the arrangement is configured to transmit a loading rotation of the base to a substantially axial loading movement of the holding member towards the base, and wherein the holding member has a locking structure exposed to the container chamber. An aerosol dispenser having the arrangement and a method for activating an aerosol dispenser are also provided. 115- (canceled)16. An arrangement for activating an aerosol dispenser , the arrangement comprising:a conveying tube for conveying a liquid;a movable holding member holding the conveying tube;a rotatable base; anda container chamber between the holding member and the base;wherein the arrangement is configured to transmit a loading rotation of the base to a substantially axial loading movement of the holding member towards the base; andwherein the holding member comprises a locking structure exposed to the container chamber.17. The arrangement according to claim 16 , wherein the locking structure comprises at least two resilient arms.18. The arrangement according to claim 16 , wherein the base comprises a rigid structure protruding towards the holding member.19. The arrangement according to claim 16 , wherein the base comprises a resilient element facing the holding member.20. The arrangement according to claim 18 , wherein the resilient element extends beyond the rigid structure towards the holding member in an uncompressed state of the resilient element.21. The arrangement according to claim 16 , wherein the locking structure projects further towards the base than the conveying tube.22. An aerosol dispenser comprising an arrangement according to .23. The aerosol dispenser according to claim 22 , further comprising a container.24. The aerosol dispenser according to claim 23 , ...

TREATMENT OF ALLERGIC RHINITIS USING A COMBINATION OF MOMETASONE AND OLOPATADINE

The present invention relates to a method of treating allergic rhinitis in a subject (e.g., a pediatric human subject) in need thereof comprising nasally administering to the subject an effective amount of a fixed-dose pharmaceutical composition comprising mometasone or its salt and olopatadine or its salt. 1. A method of treating symptoms associated with allergic rhinitis in a pediatric human subject in need thereof comprising nasally administering twice daily , one spray per nostril of a fixed-dose pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride , wherein each spray comprises about 25 mcg of mometasone furoate and about 665 mcg olopatadine hydrochloride.2. (canceled)3. The method of claim 1 , wherein the symptoms are selected from nasal symptoms.4. The method of claim 3 , wherein the nasal symptoms are selected from nasal congestion claim 3 , rhinorrhea claim 3 , itching and sneezing.5. The method of claim 1 , wherein the human subject is 2 to under 12 years of age.6. The method of claim 1 , wherein the human subject is 2 to under 6 years of age.7. The method of claim 1 , wherein the human subject is 6 to under 12 years of age.8. The method of claim 1 , wherein the allergic rhinitis is selected from seasonal allergic rhinitis claim 1 , perennial allergic rhinitis claim 1 , and persistent allergic rhinitis.9. The method of claim 8 , wherein the allergic rhinitis is seasonal allergic rhinitis.10. The method of claim 8 , wherein the allergic rhinitis is perennial allergic rhinitis.11. The method of wherein the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 15 minutes of administration.12. The method of claim 1 , wherein the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 10 minutes of administration.13. A method of treating symptoms associated with allergic rhinitis in a pediatric human ...

DOSE DIVIDER SYRINGE

A syringe includes a barrel having an internal surface defining an internal bore therein; a plunger having a distal end disposed within the internal bore of the barrel, and a proximal end disposed outside the internal bore of the barrel; and a dose divider configured to bear on the barrel in response to translation of the plunger relative to the barrel along the longitudinal direction. The dose divider includes a base including a flange that extends at least partly in a radial direction; and at least one column extending away from the base along the longitudinal direction. The at least one column includes a proximal end and a distal end opposite the proximal end, the proximal end of the at least one column being coupled to the base. The at least one column includes a sacrificial portion coupled to a frangible link. 1. A dose divider for a syringe , the dose divider comprising:a base including a flange that extends at least partly in a radial direction; andat least one column extending away from the base along a longitudinal direction, the longitudinal direction being perpendicular to the radial direction,the at least one column including a proximal end and a distal end opposite the proximal end, the proximal end of the at least one column being coupled to the base, andthe at least one column including a sacrificial portion coupled to a frangible link.2. The dose divider of claim 1 , wherein the at least one column is coupled to the base via the frangible link.3. The dose divider of claim 2 , wherein the at least one column further includes a fixed portion coupled to the sacrificial portion via the frangible link claim 2 , the fixed portion being coupled to the base.4. The dose divider of claim 1 , wherein the base further includes a wall extending away from the flange along the longitudinal direction claim 1 , andwherein the proximal end of the at least one column is coupled to the base via the wall.5. The dose divider of claim 4 , wherein the wall is an annular ...

Inhalation Atomizer Comprising a Blocking Function and a Counter

This invention presents an inhalation atomizer comprising a blocking function through a locking-mechanism and a counter along with a method to discharge and atomize fluid. The apparatus is accommodated in a two part housing, wherein the two parts are mounted to be rotatable relative to each other, and can be blocked through a locking mechanism. 11. An inhalation atomizer comprising:{'b': 17', '29', '26', '27', '28', '29', '28', '27', '1', '26', '17', '24', '26', '26', '24', '16', '16', '25', '25', '24', '24', '24', '26', '2', '3', '12', '2', '2', '9', '2, 'i': b', 'b,, 'a block function through a locking mechanism, wherein a lower unit with protrusion B is nested in the counter with an indentation and a protrusion A , and the protrusion B and protrusion A are on the same horizontal level and able to move and rotate in the continuous indentation , and when the inhalation atomizer is actuated each time, the counter makes a rotation with a constant angle around the lower unit and when Protrusion A and Protrusion B encounter with each other the counter is prevented from further rotation and hence the atomizer is locked and stopped from further use; a counter, wherein the counter has a worm and a counter ring , the counter ring is a circular with dentate part at the bottom, and the worm with upper and lower end gears contacting with the upper shell , and the upper shell comprises an inside bulge , and when the said bulge passes through the upper end gear of the worm , the worm is driven to rotate. The rotation of the worm drives the rotation of the counter ring through the lower end gear, resulting in the counting effect; a fluid in a vessel ; a nozzle for the delivery and atomization of the fluid , wherein the fluid is delivered in metered individual full-doses; and a delivering element in the form of a delivering tube , which is movable for delivering the fluid, which is movable for delivery and atomization of the fluid .'}212. The inhalation atomizer according to ...

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 2. The method of claim 1 , wherein the opioid of Formula (I) is selected from the group consisting of fentanyl claim 1 , 2 claim 1 ,5-dimethylfentanyl claim 1 , 3-allylfentanyl claim 1 , 3-methylbutyrfentanyl claim 1 , 3-methylfentanyl claim 1 , 3-methylthiofentanyl claim 1 , 4-fluorobutyrfentanyl claim 1 , p-chloroisobutyrfentanyl claim 1 , p-fluoroisobutyrfentanyl claim 1 , 4-fluorofentanyl claim 1 , 4-phenylfentanyl claim 1 , 4-methoxybutyrfentanyl claim 1 , acrylfentanyl claim 1 , α-methylacetylfentanyl claim 1 , α-methylbutyrfentanyl claim 1 , α-methylfentanyl claim 1 , α-methylthiofentanyl claim 1 , acetylfentanyl claim 1 , alfentanyl claim 1 , benzylfentanyl claim 1 , β-hydroxyfentanyl claim 1 , β-hydroxythiofentanyl claim 1 , β-methylfentanyl claim 1 , butyrfentanyl claim 1 , brifentanyl claim 1 , carfentanyl claim 1 , cyclopentylfentanyl claim 1 , isobutyrfentanyl claim 1 , furanylfentanyl claim 1 , furanylethylfentanyl claim 1 , lofentanyl claim 1 , N-methylcarfentanyl claim 1 , methoxyacetylfentanyl claim 1 , mirfentanyl claim 1 , ocfentanyl claim 1 , ohmefentanyl claim 1 , R-30490 claim 1 , remifentanil claim 1 , sufentanyl claim 1 , thenylfentanyl claim 1 , thiofentanyl claim 1 , trefentanyl claim 1 , and valerylfentanyl.3. The method of claim 1 , wherein the spray is delivered as a round plume with an ovality ratio less than about 1.5 when measured at 3 cm.4. The method of claim 3 , wherein the pharmaceutical solution further comprises between about 0.2% and about 1.2% (w/v) of an isotonicity agent.5. The method of claim 4 , wherein the pharmaceutical solution further comprises between about 0.005% and about 0.015% (w/v) of a preservative.6. The method of claim 5 , wherein the ...

SYRINGE TYPE EJECTION DEVICE

A syringe type ejection device capable of reducing an amount of residual liquid is provided. A syringe type ejection device includes: a barrel; a nozzle disposed to face the barrel; and a core inserted in the nozzle, the barrel having a large-diameter portion provided with a discharge space for discharging liquid, the nozzle being provided with a holding space for holding the core, the holding space being in communication with the discharge space, and the core being inserted in the discharge space. 1. A syringe type ejection device comprising:a barrel;a nozzle disposed to face the barrel; andan annular packing interposed between the barrel and the nozzle,the barrel having a tip end portion provided with a discharge space for discharging liquid, the tip end portion including a first surface facing the nozzle,the nozzle being provided with a holding space for holding a core, the holding space being in communication with the discharge space,the nozzle including a second surface facing the first surface,the annular packing being provided to be in contact with the first surface and the second surface to enable movement of the liquid from the discharge space to the holding space, andthe syringe type ejection device further comprising a biasing portion that biases the first surface and the second surface toward the annular packing.2. The syringe type ejection device according to claim 1 , whereinthe biasing portion is provided on the nozzle.3. The syringe type ejection device according to claim 2 , whereinthe biasing portion covers the tip end portion.4. The syringe type ejection device according to claim 2 , whereinthe tip end portion has a large-diameter portion, and the biasing portion engages the large-diameter portion.5. The syringe type ejection device according to claim 4 , whereinthe biasing portion has a plurality of hooks that engage the large-diameter portion.6. The syringe type ejection device according to claim 5 , whereinthe biasing portion is flexible, and a ...

DEVICES, SYSTEMS AND METHODS FOR LOCATING AND INTERACTING WITH MEDICAMENT DELIVERY SYSTEMS

In some embodiments, a method includes establishing a communications link between a computing device and an adapter. The adapter is configured to receive at least a portion of a medicament delivery device. A wireless signal is received to maintain the communications link. A relative position between the computing device and the adapter is determined. An alarm is produced when the wireless signal is not received within a time period. The alarm is based on the relative position between the computing device and the adapter. 1. A method , comprising:establishing a communications link, via a short-range wireless protocol, between a computing device and a medicament delivery device, the medicament delivery device including an electronic circuit system, the electronic circuit system including a radio;receiving a first wireless signal from the radio to maintain the communications link, the first wireless signal being periodic;producing a first alarm when the first wireless signal is not received within a time period, the first alarm indicating that the computing device is out of a communication range of the medicament delivery device;receiving a user input in response to a location prompt; andtransmitting to the radio a second wireless signal, the second wireless signal including instructions that, when received by the radio, cause the electronic circuit system to produce a second alarm, the second alarm including at least one of an audible output or a visual output.2. The method of claim 1 , wherein the medicament delivery device is any one of an auto-injector claim 1 , a nasal delivery device or an inhaler.3. The method of claim 1 , further comprising:determining, based at least in part on the first wireless signal, a location of the medicament delivery device; andproducing, via the computing device, a location alert indicating the location.4. The method of claim 1 , further comprising:receiving a third wireless signal from the radio, the third wireless signal associated ...

Medicament delivery device for administration of opioid antagonists including formulations for naloxone

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

APPARATUS FOR DELIVERING AEROSOLIZED MEDICATION

An apparatus for delivering an aerosolized medication to a patient on a ventilation circuit. The apparatus comprise a multi dose metered syringe preloaded with the aerosolized medication such as albuterol. The syringe comprises a Luer lock at a bottom tip, which is removably attachable to a carbon dioxide sampling port of an endotracheal tube. A plunger adapted to be fitted inside the syringe and actuated for delivering a predefined dose of the aerosolized medication into the endotracheal tube, without disconnecting the ventilation circuit. The delivery of aerosolized medication is synchronized with oxygen inspiration for optimal delivery. 1. An apparatus for delivering an aerosolized medication to a patient on a ventilation circuit , the apparatus comprising:a multi-dose metered syringe preloaded with the aerosolized medication, the syringe is attachable to a gas sampling port of an endotracheal tube; anda plunger configured to be actuated for delivering a predefined dose of the aerosolized medication into the endotracheal tube, without disconnecting the ventilation circuit.2. The apparatus of claim 1 , wherein the aerosolized medication is disposed in an inhaler or a pressurized canister.3. The apparatus of claim 1 , wherein the aerosolized medication comprises albuterol.4. The apparatus of claim 1 , wherein the syringe further comprises a Luer lock tip configured to be attached to the gas sampling port of the endotracheal tube.5. The apparatus of claim 1 , wherein the delivery of aerosolized medication is synchronized with oxygen inspiration.6. The apparatus of claim 5 , wherein the synchronizing is timed based on ventilation bag or bellow movement.7. The apparatus of claim 1 , wherein the gas sampling port comprises carbon dioxide sampling port. The present disclosure generally relates to delivery of aerosolized medication and more specifically relates to an apparatus for delivery of aerosolized medication to intubated patients or patients on mechanical ...

Remote-Controlled Medicine Delivery System

Aspects of the present invention provide a method and a remote-controlled guidance system for delivering and applying medicines to a region of the body that may not otherwise be easily accessible (e.g., to the perianal region). The system is designed to enable the user to administer their medicine at a desirable angle they control, while the user is in a relatively comfortable and efficacious position for the treatment. The device can present a safer, more hygienic, and more effective alternative method to self-administer perianal medicines than any option currently available. To this extent, the system can present a discreet, “hands-free” alternative to the current options, or couple to other system, such as a bidet toilet seat system, thereby substantially eliminating any discomfort, ineffectiveness, and/or embarrassment a user might otherwise experience. 1. A remote-controlled delivery system , comprising:a nozzle delivery assembly;a first motor being connected to the nozzle delivery assembly and capable of directing one or more extending and retracting movements of the nozzle delivery assembly;one or more second motors being connected to the nozzle delivery assembly and capable of directing one or more three-dimensional rotational movements of the nozzle delivery assembly; andone or more dynamic steering remote control units adapted to be communicating with both the first motor and the one or more second motors and directing one or more movements of the first motor and the one or more second motors.2. The remote-controlled delivery system of claim 1 , wherein the nozzle delivery assembly comprises a wash nozzle and a medicinal delivery nozzle.3. The remote-controlled delivery system of claim 2 , wherein the wash nozzle further comprises a water jet head.4. The remote-controlled delivery system of claim 2 , wherein the medicinal delivery nozzle further comprises a medicinal liquid inlet being connected to a medicinal storage assembly.5. The remote-controlled ...

Nebulizer

A nebulizer and a housing part for a nebulizer are proposed, wherein a container containing the fluid to be nebulized is provided. The container is moveable back and forth for conveying and nebulization of the fluid. A securing device forms a transportation lock for holding the container unmovable in a delivery state with closed transportation lock. A control part opens the transportation lock by means of at least one rib or arm when the control part is moved towards the securing device. The securing device comprises a ring-like holding part with inwardly extending holding elements for holding the container inseparably.

Microstructured nozzle and production thereof

The invention relates to a nozzle for use in a device for administering a liquid medical formulation, to a method for producing the nozzle in the form of a microfluidic component and to a tool for producing microstructures of the microfluidic component. The nozzle is formed by a plastics plate with groove-like microstructures which are covered by a plastics cover on the longitudinal side in a fixed manner. The production method includes a moulding process in which a moulding tool is used, which moulding tool has complementary metal microstructures which have been produced from a semiconductor material in an electrodeposition process by means of a master component.

Dispenser comprising actuating piston and outlet check valve

A valved container assembly which has a container for containing a fluid, the container extending in an axial direction and having an open front end and a valve disposed in the container. The valved container assembly is configured so that forward axial movement of the valve relative to the container is inhibited. A plunger element is disposed axially rearward of the valve and is axially moveable in the container. The plunger element is configured to increase the pressure of a fluid in a first volume of the container upon forward axial movement relative to the valve. The valve includes a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal.

MEDICAMENT DISPENSER SIMULATOR

A device () for simulating the dispensing of a medication into the nasal passage. The device includes a device body (), the device body defining an extending portion () for inserting into the nasal passage of a user. An activation mechanism () movable from a start position to a dispensed position can be returned to the start position by manipulation of part of the device. Manipulation may be by rotation of a main part of the device body () relative to the extending portion (). 1. A device for simulating the dispensing of a medication into the nasal passage , the device comprising:a device body, the device body defining an extending portion for inserting into the nasal passage of a user; andan activation mechanism movable from a start position to a dispensed position;wherein the activation mechanism can be returned to the start position by manipulation of part of the device.2. The device of claim 1 , wherein the activation mechanism is movable from the start position to the dispensed position by the application of a force.3. The device of claim 1 , wherein movement of the activation mechanism is relative to the device body when moving from the start position to the dispensed position.4. The device of claim 1 , wherein the activation mechanism is in a telescopic relationship with the device body.5. The device of claim 1 , wherein the activation mechanism engages an at least one activation profile when moving from the start position to the dispensed position.6. The device of claim 5 , wherein the at least one activation profile is defined by a guide member located within the device body.7. The device of claim 5 , wherein the at least one activation profile is defined by an internal surface of the device body.8. The device of claim 5 , wherein the activation mechanism includes an at least one engaging member claim 5 , the/each engaging member adapted to engage with the/one of the activation profiles.9. The device of claim 5 , wherein the/each activation profile resists ...

Container, Indicator Device, and Nebulizer

A nebulizer as well as a container and an indicator device for such a nebulizer are proposed. The indicator device is fixedly mounted from the bottom of the container and comprises a piercing element for opening an aeration of the container. The indicator device and its piercing part are preferably actuated by axial movement of the indicator device and container within the nebulizer. 1. A container for a nebulizer , the container containing a fluid , and the container comprising an indicator device for counting and/or indicating a number of uses performed or still possible with the container , wherein the indicator device comprises a piercing part for opening an aeration of the container.2. The container according to claim 1 , wherein the indicator device is inseparable from the container.3. The container according to claim 1 , wherein the indicator device is arranged adjacent to or over an aeration opening or venting hole or to an associated closure or foil of the container.4. The container according to claim 1 , wherein the indicator device comprises a compensation portion for compensating tolerances or over-travel in axial actuation.5. An indicator device for a container containing a fluid to be nebulized by a nebulizer claim 1 , the indicator device comprising an indicator element for counting and/or indicating a number of uses performed or still possible with the container claim 1 , wherein the indicator device comprises a piercing part for opening an aeration of the container claim 1 , and/or the indicator device comprises a protection and/or closure claim 1 , in particular for closing an insertion opening of the indicator device.6. The indicator device according to claim 5 , wherein the piercing part is arranged within the indicator device or its housing claim 5 , if not actuated or before first use or actuation.7. The indicator device according to claim 5 , wherein the piercing part is held—preferably by form-fit claim 5 , snap-fit or force-fit or by a ...

Spray Tips for Simultaneous Multi-Directional Delivery of Dissimilar Fluids

The present inventions are directed to spray tips for multidirectional or three-dimensional spraying of an unmixed two-part sealant and/or hemostat comprising a first biocompatible component and a biocompatible second component onto a tissue or wound comprising: a hollow body having inside a first component distribution compartment and a second component distribution compartment, said compartments not in fluid communication with each other. The first component can contain one or more biologic components, preferably fibrinogen and the second component can contain one or more biologic component different from the first biologic component, preferably thrombin and/or thrombin precursors. The present inventions are also directed to methods of spraying the unmixed two-part sealant or hemostat using the spray tip and associated components described above by simultaneously expressing the first component and the second component from the syringes. 1. A spray tip for multidirectional or three-dimensional spraying of an unmixed two-part sealant and/or hemostat comprising a first biocompatible component and a biocompatible second component onto a tissue or wound comprising:a hollow body having inside a first component distribution compartment and a second component distribution compartment, said compartments not in fluid communication with each other;conduits to supply the first component into the first component distribution compartment and the second component into the second component distribution compartment;a plurality of first exit orifices on spray tip in fluid communication with the first component distribution compartment and a plurality of second exit orifices on spray tip in fluid communication with the second component distribution compartment;wherein said first exit orifices are positioned alternatingly with said second exit orifices around the spray tip;wherein said exit orifices point towards outside of the spray tip in multiple directions.2. The spray tip of ...

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 1. A prefilled nasal delivery device comprising:a reservoir containing a pharmaceutical composition comprising naloxone hydrochloride, an amount of water sufficient to achieve a therapeutically effective amount of about 8 mg naloxone hydrochloride per 100 μL, an amount of hydrochloric acid sufficient to achieve a pH of 3.5-5.5, and propylene glycol, and;wherein the device is configured to deliver the therapeutically effective amount of about 8 mg naloxone hydrochloride or an equivalent thereof in a single use device to a patient suffering from or suspected to be suffering from opioid overdose, without the need for a caregiver to prime the device.2. The prefilled nasal delivery device of claim 1 , wherein the pharmaceutical composition further comprises disodium edetate.3. The prefilled nasal delivery device of claim 1 , wherein the pharmaceutical composition further comprises an alcohol.4. The prefilled nasal delivery device of claim 1 , wherein naloxone hydrochloride is the only pharmaceutically active compound in the pharmaceutical composition.5. The prefilled nasal delivery device of claim 1 , wherein the pharmaceutical composition is storage stable.6. The prefilled nasal delivery device of claim 1 , wherein the patient is a human.7. The prefilled nasal delivery device of claim 1 , wherein the pharmaceutical composition provides a maximum observed plasma concentration of naloxone after administration (C) of about 9.52 ng/ml to about 10.9 ng/ml after delivery to the patient.8. The prefilled nasal delivery device of claim 1 , wherein the pharmaceutical composition provides a Cof about 10.3 ng/ml of naloxone after delivery to the patient.9. The prefilled nasal delivery device of claim 1 , wherein ...

Method and apparatus for irrigation

Disclosed is an irrigation system. The irrigation system includes a manual pump. The manual pump can provide pressurized liquid through a tube at an outlet.

Nasal aerosol delivery system

A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

SYSTEM AND METHOD FOR CONTROLLED MEDICAL THERAPY

The present invention relates to a system and method for dispensing medication through a time controlled device linked to a web platform. The system includes a dispensing device in wireless communication with a computing device. A web platform on the computing device can be used to program the dispensing device with parameters such as the dosage number, minimum time period between dosages, and the like. Based on the programmed parameters, a solenoid in the dispensing device will lock or unlock based on dosages administered and the time between dosages. 1. A system for a time-controlled medication dispensing , comprising:a computing device; a cylindrical housing with a first closed end and a second closed end;', 'wherein the first closed end has a surface and a nozzle which moves perpendicular relative to the surface;', 'a liquid container within the housing having a pump assembly connected thereto, the pump assembly actuable through movement of the nozzle toward the surface;', 'a processor located within the housing and configured to actuate a locking mechanism within the housing according to instructions transmitted from the computing device;', 'wherein, in a locked position, the locking mechanism blocks the nozzle from depressing to the surface of the first closed end., 'a dispensing device wirelessly connected to the computing device, the dispensing device comprising2. The system of claim 1 , wherein the locking mechanism is a solenoid within the housing which moves perpendicular to the nozzle.3. The system of claim 1 , wherein claim 1 , in an unlocked position claim 1 , the locking mechanism does not block the nozzle from moving to the surface of the first closed end.4. The system of claim 1 , wherein the locking mechanism comprises a motor assembly having a motor which rotates a gear within an internal gear wheel.5. The system of claim 4 , further comprising:a lock on the internal gear wheel, the lock having a keyway; anda shaft on the pump assembly having one ...

MEDICAMENT DELIVERY DEVICE FOR ADMINISTRATION OF OPIOID ANTAGONISTS INCLUDING FORMULATIONS FOR NALOXONE

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition. 1. A method , comprising:providing a naloxone composition configured for use in a medicament delivery device, the naloxone composition including a tonicity-adjusting agent, the pH of the naloxone composition ranging from 3 to 5; andassembling the medicament delivery device, the medicament delivery device including a housing, a medicament container disposed within the housing and defining an internal volume containing the naloxone composition, an elastomeric member that seals the naloxone composition within the medicament container, and a delivery member coupled to the medicament container, and the assembling including removably coupling a cover or case to the housing of the medicament delivery device.2. The method of claim 1 , wherein:the medicament delivery device is an auto-injector; andthe delivery member is a needle, the needle being coupled to the medicament container via a coupling member, the needle being fluidically isolated from the internal volume when the coupling member and the medicament container are in a first configuration, the needle in fluid communication with the internal volume when the coupling member and the medicament container are in a second configuration.3. The method of claim 1 , wherein:the medicament delivery device is an intranasal spray device; andthe delivery member is associated with an atomizer defining an orifice ...

Hemostatic Powder Delivery Devices and Methods

The present invention is directed to a device for the expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the reservoir between the bellows and plunger and the expression port, and a spring is disposed within the reservoir between the air pump and the plunger. The powder is disposed within the reservoir between the porous filter and the expression port, and the pump is in a fluid communication with the expression port through the porous filter and through the powder. 2. The device of claim 1 , wherein said manual air pump comprises a bellows.3. The device of claim 1 , wherein said filter comprises interconnected pores or channels having size substantially preventing the powder from passing through the filter.4. The device of claim 1 , wherein said porous filter is attached to a plunger slidably disposed within the reservoir between said filter and said manual air pump and a hollow expression cannula is attached to said expression port and extends from the device distally claim 1 , said expression cannula is in fluid communication with said pump.5. The device of claim 4 , wherein said plunger has an elongated stem extending from said plunger towards the proximal end and said spring is at least partially supported on said stem.6. The device of claim 4 , further comprisinga) a powder trap positioned between the expression port and the expression cannula, the powder trap comprisingi) a tortuous channel for the powder, the channel having an entrance orifice open to the reservoir and an exit opening open to the expression cannula.7. The device of claim 6 , further comprising a blocking member within the reservoir claim 6 , wherein said powder trap is rotatable about the reservoir from a first position to a second position and in the first position the entrance orifice is blocked by the blocking member and in the ...

Fluid Dispensing Device

The disclosure relates to a fluid dispensing device comprising: a housing comprising an orifice and configured to accommodate a portion of a spray delivery device comprising an outlet, a protective cap configured to accommodate the outlet of the spray delivery device and comprising a cap portion, wherein the protective cap is configured for fitting to the housing so that the cap portion covers the orifice, a biasing member transferable between a pre-loaded state and an unloaded state and configured to store energy in the pre-loaded state to produce a discharge of the spray delivery device, a releasable interlock configured to retain the biasing member in the pre-loaded state, a trigger engaged with the interlock and configured to release the interlock when actuated, wherein release of the energy stored in the pre-loaded biasing member is prevented as long as the cap portion covers the orifice. 120-. (canceled)21. A fluid dispensing device comprising:a housing, the housing comprising an orifice and wherein the housing is configured to accommodate at least a portion of a spray delivery device comprising an outlet through which a fluid stored in the spray delivery device can be discharged, a protective cap defining an interior space configured to accommodate the outlet of the spray delivery device and comprising at least a cap portion, wherein the protective cap is configured for fitting to the housing at least in a closing position relative to the housing, in which the cap portion covers the orifice,', 'a mechanical biasing member reversibly transferable between a pre-loaded state and an unloaded state and configured to store mechanical energy in the pre-loaded state effective to produce a spray discharge of the spray delivery device,', 'a releasable interlock configured to retain the biasing member in the pre-loaded state, and', 'a manually actuatable trigger operationally engaged with the interlock and configured to release the interlock when actuated,, 'the fluid ...

Hemostatic Powder Delivery Devices and Methods

The present invention is directed to a device for the expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the reservoir between the bellows and plunger and the expression port, and a spring is disposed within the reservoir between the air pump and the plunger. The powder is disposed within the reservoir between the porous filter and the expression port, and the pump is in a fluid communication with the expression port through the porous filter and through the powder. 2. The device of claim 1 , wherein said manual air pump comprises a bellows.3. The device of claim 1 , wherein said filter comprises interconnected pores or channels having size substantially preventing the powder from passing through the filter.4. The device of claim 1 , wherein said porous filter is attached to a plunger slidably disposed within the reservoir between said filter and said manual air pump and a hollow expression cannula is attached to said expression port and extends from the device distally claim 1 , said expression cannula is in fluid communication with said pump.5. The device of claim 4 , wherein said plunger has an elongated stem extending from said plunger towards the proximal end and said spring is at least partially supported on said stem.6. The device of claim 4 , further comprising 'i) a tortuous channel for the powder, the channel having an entrance orifice open to the reservoir and an exit opening open to the expression cannula.', 'a) a powder trap positioned between the expression port and the expression cannula, the powder trap comprising'}7. The device of claim 6 , further comprising a blocking member within the reservoir claim 6 , wherein said powder trap is rotatable about the reservoir from a first position to a second position and in the first position the entrance orifice is blocked by the blocking member and in ...

DEVICE FOR CELL SPRAYING

The invention provides a description of a method and a device suitable for producing a cell suspension spray with living cells, and the produced cell preparation, suitable for grafting to a patient. In contrast to other methods, the spraying is performed through a disposable needle which is inserted into a disposable air tube; which provides a cell distribution avoiding spray nozzles. Small suspension droplets are provided instead of cell nebulization. By using medical grade sterile Luer-lock disposables from medical routine praxis, biocompatibility and easy application is addressed. In applying the method and/or in using the device, cells suitable for grafting to a patient are dispersed in a solution and sprayed with the device for distribution over the recipient graft site. 1providing continuous spray application over a range of 0.5-10 Minutes, preferably 1-2 Minutes in a single shot and/or in several shots, while generating liquid/suspension drops ranging between 10-500 Micrometer in size, exhibiting a hollow needle to deposit liquids/suspensions, which isconnected at the outlet of a biocompatible container delivering a liquid/suspension stream towards the tip of the needle,injected with the tip into a biocompatible tube delivering a gas and/or air stream in direction to the end of the tube where the tip of the needle is positioned, whereasthe needle exhibits an inner lumen of 25 G to 34 G, preferably of 27 G to 30 G, andthe needle is injected into the tube in a way that the tip of the needle ends within +/−3 Millimeter, preferably +/−0.2 Millimeter at the end of the tube,the tip of the needle runs within the tube at least 2-100 Millimeter, preferably 4-20 Millimeter in parallel to the tube so that the needle tip is centered in the end of the tube lumen,the tube exhibits an inner diameter of 1.5-0.2 Millimeter, preferably of 0.8-0.6 Millimeter,the tube bends at the point of needle injection with a radius not prohibiting the gas flow to the side in an angle of 1 ...

FOAM APPLICATOR FOR IN-EAR USE

A device for dispensing a foam medication into a human or animal ear includes a supply of foamable medicine held within a container. The medicine is advanced through a delivery tube that is configured to engage an ear without entering the ear canal to an extent that it contacts the eardrum. The delivery tube has an enlarged end portion that prevents the device from being inserted too far into an ear, and the enlarged end portion has a series of openings oriented in two different directions to deliver foam into the ear forward of the device and around the circumference of the delivery tube. 127-. (canceled)28. A foam medication dispensing apparatus for use in treatment of conditions within a subject's ears , said foam medication dispensing apparatus comprising:(1) a container having a medication reservoir adapted to contain foamable medication;(2) a nozzle supported by said container in communication with said reservoir and providing a flowpath for said foamable medication out of said container; ["(i) a proximal end operatively connected to said nozzle to define a flowpath for said foamable medication from said medication reservoir to a subject's ear canal, said subject's ear canal including a vertical ear canal section and a horizontal ear canal section; and", "(ii) a distal delivery end opposite to said proximal end, said delivery tube outer wall including a set of foam-directing openings extending therethrough and arranged near said distal delivery end, said set of foam-directing openings defining a set of individual flowpaths communicating between said delivery tube and a surrounding area of said subject's ear when said distal delivery end is inserted into said subject's ear, said set of foam-directing openings including a primary foam-directing opening adapted to release said foamable medication into said horizontal ear canal section; and,"], '(3) a hollow delivery tube, said delivery tube being defined by an outer wall, said delivery tube having (iii) said ...

Fluid product dispensing device

A fluid dispenser device comprising: a reservoir ( 10 ) containing at least two doses of fluid; a dispenser member ( 20 ), such as a piston, that is mounted to slide in said reservoir ( 10 ) so as to dispense the fluid; a dispenser head ( 30 ) that is provided with a dispenser orifice ( 31 ), said head being movable relative to said reservoir ( 10 ) so as to move said actuator member ( 20 ) in said reservoir ( 10 ) and thus dispense the fluid through said dispenser orifice ( 31 ); said dispenser head ( 30 ) including at least two viewing windows ( 35, 36 ), said device including an indicator ( 40 ) that is movable together with said reservoir ( 10 ), said indicator ( 40 ) co-operating with a respective viewing window ( 35, 36 ) after each actuation of the device.

CONTROLLED INHALER FOR DISTRIBUTING INHALANT ACCORDING TO INHALATION VELOCITY

An inhaler is provided that includes a controller, a driver, an atomizer and one or more sensors for detecting information about a velocity of inhalation of a user of the inhaler. The controller is configured to dispense an inhalant from the inhaler during an inhalation of the user based on information about the velocity of inhalation of the user. Such information can include a duration of maximum inhalation velocity or an increase or maximum in the acceleration in inhalation velocity. Embodiments of the inhaler can be used to enhance the delivery of drugs and therapeutic agents for those patients having a weakened respiratory system who are unable to take a deep or full breadth, e.g., patients having asthma or COPD. Embodiments of the inhaler can be used to deliver a variety of drugs and therapeutic agents including agents for the treatment of asthma, diabetes, epilepsy and heart disease. 1. (canceled)2. A method for delivering an inhaled therapeutic agent to a user using an inhaler , the method comprising:detecting information about an inhalation velocity of the user during a first inhalation; wherein the information is used to derive an inhalation velocity profile; anddelivering an aerosoled form of the therapeutic agent into the user's lungs during a subsequent inhalation, wherein a dispense velocity of delivering the aerosoled form of the therapeutic agent is controlled based at least in part on the derived inhalation velocity profile.3. The method of claim 2 , wherein the detected information includes identification of a duration of maximum inhalation velocity or a maximum acceleration in inhalation velocity.4. The method of claim 2 , wherein delivering the aerosoled form of the therapeutic agent is synchronized to occur at or during a period of (i) maximum inhalation velocity claim 2 , or a (ii) maximum acceleration in inhalation velocity.5. The method of claim 2 , wherein delivering the aerosoled form of the therapeutic agent includes delivering a ...

EAR SPRAY DEVICE AND EAR PROTECTION COMPOSITION FOR PREVENTING WATER RELATED EAR CANAL DISORDERS

An ear spray device dispensing a pre-defined quantity of an ear protection composition capable of preventing ear canal disorders. The said composition includes Paraffinum Liquidum within the range of 90.0 percent w/v to 99.9 percent w/v, and Oreganum Oil within the range of 10.0 percent w/v to 0.1 percent w/v. The ear spray device includes a reservoir containing the said ear protection composition and a spray nozzle attached with the said reservoir through a pump mechanism. The said spray nozzle is adapted to spray the said composition in the ear canal of the user when the said device is in a substantially upright or a substantially inverted position. 1. An ear protection composition , wherein the said composition comprises:at least one mineral oil within the range of 90.0 percent w/v to 99.9 percent w/v, wherein, the said mineral oil is selected from Paraffinum Liquidum; andat least one vegetable oil within the range of 10.0 percent w/v to 0.1 percent w/v, wherein, the said vegetable oil is selected from an Oreganum Oil.2. The ear protection composition as claimed in claim 1 , wherein the said mineral oil is in the range of 98.0 percent w/v to 99.9 percent w/v claim 1 , and the said vegetable oil is within the range of 2.0 percent w/v to 0.1 percent w/v.3. The ear protection composition as claimed in claim 2 , wherein the said mineral oil is in the range of 99.6 percent w/v to 99.9 percent w/v claim 2 , and the vegetable oil is within the range of 0.4 percent w/v to 0.1 percent w/v.4. The ear protection composition as claimed in claim 1 , wherein the said composition is used for protecting a user's ear from waterborne ear canal disorders caused due to trapping of water in an ear canal of a person.5Oreganum compactum,Oreganum vulgare,. The ear protection composition as claimed in claim 1 , wherein the said Orenagum Oil is an essential oil selected from at least one of an an or a combination thereof.6. The ear protection composition as claimed in claim 1 , wherein ...

Methods and Devices for Co-Delivery of Liquid and Powdered Hemostats and Sealants

The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices. 1. An integrated delivery device operable with one hand and for co-delivery of a liquid medicant and a powder medicant onto a tissue or wound comprising at least two integrated medicant expression subunits ofa) a liquid medicant expression subunit and a a. each expression subunit having an actuator for the medicant contained therein, the actuators are positioned in close proximity to each other at a proximate end of said expression subunits, and', 'b. delivery cannulas for each of said expression subunits that positioned in close proximity to each other at a distal end of said expression subunits., 'b) a powder medicant expression subunit,'}2. The integrated delivery device of claim 1 , wherein the liquid medicant expression subunit comprises a syringe containing the liquid medicant claim 1 , and the powder medicant expression subunit comprises a powder delivery pump.3. The integrated delivery device of claim 2 , wherein the liquid medicant comprises a two-part sealant or hemostat claim 2 , and the syringe comprises a dual barrel syringe with each barrel containing one of different individual components of the two-part sealant or hemostat.4. The integrated delivery device of claim 3 , wherein the powder delivery pump comprises a resiliently compressible bellows and a ...

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 2. The method of claim 1 , wherein the opioid of Formula (I) is selected from the group consisting of fentanyl claim 1 , 2 claim 1 ,5-dimethylfentanyl claim 1 , 3-allylfentanyl claim 1 , 3-methylbutyrfentanyl claim 1 , 3-methylfentanyl claim 1 , 3-methylthiofentanyl claim 1 , 4-fluorobutyrfentanyl claim 1 , p-chloroisobutyrfentanyl claim 1 , p-fluoroisobutyrfentanyl claim 1 , 4-fluorofentanyl claim 1 , 4-phenylfentanyl claim 1 , 4-methoxybutyrfentanyl claim 1 , acrylfentanyl claim 1 , α-methylacetylfentanyl claim 1 , α-methylbutyrfentanyl claim 1 , α-methylfentanyl claim 1 , α-methylthiofentanyl claim 1 , acetylfentanyl claim 1 , alfentanyl claim 1 , benzylfentanyl claim 1 , β-hydroxyfentanyl claim 1 , β-hydroxythiofentanyl claim 1 , β-methylfentanyl claim 1 , butyrfentanyl claim 1 , brifentanyl claim 1 , carfentanyl claim 1 , cyclopentylfentanyl claim 1 , isobutyrfentanyl claim 1 , furanylfentanyl claim 1 , furanylethylfentanyl claim 1 , lofentanyl claim 1 , N-methylcarfentanyl claim 1 , methoxyacetylfentanyl claim 1 , mirfentanyl claim 1 , ocfentanyl claim 1 , ohmefentanyl claim 1 , R-30490 claim 1 , remifentanil claim 1 , sufentanyl claim 1 , thenylfentanyl claim 1 , thiofentanyl claim 1 , trefentanyl claim 1 , and valerylfentanyl.3. The method of claim 1 , wherein the spray is delivered as a round plume with an ovality ratio less than about 1.5 when measured at 3 cm.4. The method of claim 3 , wherein the pharmaceutical solution further comprises between about 0.2% and about 1.2% (w/v) of an isotonicity agent.5. The method of claim 4 , wherein the pharmaceutical solution further comprises between about 0.005% and about 0.015% (w/v) of a preservative.6. The method of claim 5 , wherein the ...

TREATMENT OF NEONATAL BRAIN INJURY WITH HB-EGF

Methods for treating brain injury caused by or associated with hypoxia or a hypoxic state, especially neonatal brain injury, using heparin-binding EGF-like growth factor. 1. A method for treating a subject having a brain injury caused by or associated with hypoxia comprising administering heparin-binding EGF-like growth factor , a functional fragment thereof , or a variant thereof to said subject.2. The method of claim 1 , wherein the subject is a neonate.3. The method of claim 1 , wherein the subject is a preterm infant.4. The method of wherein the subject is a preterm infant less than 32-weeks gestation.5. The method of claim 1 , wherein the subject has diffuse white matter injury (“DWMI”).6. The method of claim 1 , wherein the subject exhibits neurodevelopmental impairment.7. The method of claim 1 , wherein the heparin-binding EGF-like growth factor claim 1 , a functional fragment thereof claim 1 , or a variant thereof was produced recombinantly.8. The method of claim 1 , comprising administering a variant or functional fragment of heparin-binding EGF-like growth factor that has an amino acid sequence that is at least 90% identical to Accession No. NP_001936 claim 1 , version NP_001936.1 (SEQ ID NO: 2).9. The method of claim 1 , comprising administering a variant or functional fragment of heparin-binding EGF-like growth factor that has an amino acid sequence that is at least 95% identical to that described by Accession No. NP_001936 claim 1 , version NP_001936.1 (SEQ ID NO: 2).10. The method of claim 1 , comprising administering an EGF-like growth factor comprising the amino acid sequence of SEQ ID NO: 2.11. The method of claim 1 , wherein heparin-binding EGF-like growth factor claim 1 , a functional fragment thereof claim 1 , or a variant thereof is administered within 0 claim 1 , 0.25 claim 1 , 0.5 claim 1 , 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , 10 claim 1 , 12 claim 1 , 15 claim 1 , 16 claim ...

NEBULIZER

A nebulizer comprises a replaceable container with fluid to be nebulized. The container comprises an inseparable indicator device. The container and the indicator device are axially moved during nebulization and tensioning of the nebulizer. The indicator device controls locking of the nebulizer against further use if a predetermined number of uses has been reached or exceeded. 1121. A nebulizer () for a fluid () , the nebulizer () comprising:{'b': 3', '2, 'a replaceable or insertable container () containing the fluid ();'}{'b': 25', '3, 'an indicator device () for counting or indicating a number of uses performed or still possible with the container ();'}{'b': 26', '1', '3', '3, 'a locking device () adapted to block further use of the nebulizer () or container () in a locked state when a predetermined number of uses has been reached or exceeded with the current container (); and'}{'b': 75', '25', '26, 'a mechanical coupling or control device () so that the indicator device () can control the locking device ();'}{'b': 3', '1', '1, 'wherein the container () is moveable in axial direction within the nebulizer () during nebulization und/or during tensioning of the nebulizer (),'}characterized in{'b': 25', '3', '3', '1, 'that the indicator device () is arranged at the container () and moveable together with the container () axially within the nebulizer () during nebulization and/or tensioning.'}21183. The nebulizer according to claim 1 , characterized in that the nebulizer () comprises a housing part () which can be detached or replaced or opened for inserting or replacing the container ().3757618. The nebulizer according to claim 2 , characterized in that the control device () or an actuation member () thereof is arranged or guided in the housing part ().47576. The nebulizer according to claim 1 , characterized in that the control device () comprises an axially moveable actuation member ().5757686. The nebulizer according to claim 1 , characterized in that claim 1 , ...

Nebulizer and container

A nebulizer and a container with a fluid for such a nebulizer are proposed. The container comprises an indicator device fixedly mounted on the bottom of the container. When a predetermined number of uses of the container ( 3 ) with the nebulizer ( 1 ) has been reached or exceeded, a signal element becomes visible on the indicator device. The indicator device stops further use of the container in a locked state when a predetermined number of uses has been reached or exceeded. Then, the nebulizer is partially opened and blocked against further use. After replacement of the container including the indicator device, the nebulizer can be used again.

Portable inhalation therapeutic and inhalation and exhalation measuring devices and related methods

A portable inhalation device includes a medication storage component, a flow controller, an atomizer, a medication delivery component, and a pressure sensor. The medication storage component is configured to store medication. The flow controller is configured to cause a force to be applied to the medication stored by the medication storage component to transport the medication to the atomizer. The atomizer is configured to generate droplets from the medication. The medication delivery component includes a delivery channel extending from the atomizer to an outlet opening. The medication delivery component is configured to receive the medication in the delivery channel from the atomizer and dispense the medication via the opening. The pressure sensor is configured to detect a pressure corresponding to a flow rate of air in the delivery channel and output an indication of the detected pressure.

TREATMENT OF ALLERGIC RHINITIS USING A COMBINATION OF MOMETASONE AND OLOPATADINE

The present invention relates to a method of treating allergic rhinitis in a subject (e.g., a pediatric human subject) in need thereof comprising nasally administering to the subject an effective amount of a fixed-dose pharmaceutical composition comprising mometasone or its salt and olopatadine or its salt. 1. A method of treating symptoms associated with allergic rhinitis in a human subject in need thereof comprising nasally administering twice daily , one or two sprays per nostril of a fixed-dose pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride , wherein each spray comprises about 25 mcg of mometasone furoate and about 665 mcg olopatadine hydrochloride.2. (canceled)3. The method of claim 1 , wherein the symptoms are selected from nasal symptoms.4. The method of claim 3 , wherein the nasal symptoms are selected from nasal congestion claim 3 , rhinorrhea claim 3 , itching and sneezing.5. The method of claim 1 , wherein the human subject is 2 to under 12 years of age.6. The method of claim 1 , wherein the human subject is 2 to under 6 years of age.7. The method of claim 1 , wherein the human subject is 6 to under 12 years of age.8. The method of claim 1 , wherein the allergic rhinitis is selected from seasonal allergic rhinitis claim 1 , perennial allergic rhinitis claim 1 , and persistent allergic rhinitis.9. The method of claim 8 , wherein the allergic rhinitis is seasonal allergic rhinitis.10. The method of claim 8 , wherein the allergic rhinitis is perennial allergic rhinitis.11. The method of claim 1 , wherein the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 15 minutes of administration.12. The method of claim 1 , wherein the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 10 minutes of administration.1325-. (canceled)26. A method of treating a human subject suffering from allergic ...

VALVED CONTAINER ASSEMBLY

A valved container assembly comprising a container for containing a fluid, the container extending in an axial direction and having an open front end, a valve disposed in the container; and a plunger element disposed axially rearward of the valve. The plunger element is axially moveable in the container and a first volume is provided in the container between the plunger element and the valve, wherein the plunger element is configured to increase a pressure of the fluid in the first volume upon axial movement of the plunger element relative to the valve. The valve comprises a seal fluidly sealing the valve to an interior of the container along an entire perimeter of the valve, and a channel bypassing the seal, the channel having a first opening in fluid communication with an atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume, wherein in the sealing configuration the resilient seal fluidly seals against the container to fluidly seal the valve to the container so as to fluidly isolate the channel from the first volume, and in the open configuration the resilient seal does not fluidly seal against the container to fluidly seal the valve to the container so that the second opening of the channel is in fluid communication with the first volume. The resilient seal is moveable from the sealing configuration to the open configuration upon the pressure of the fluid in the first volume exceeding a first pressure threshold. 1. A valved container assembly comprising:a container for containing a fluid, the container extending in an axial direction and having an open front end;a valve disposed in the container; anda plunger element disposed axially rearward of the valve, the plunger element being axially moveable in the container and wherein a first volume ...

Nebulizer and Reservoir

A reservoir for a nebulizer includes: a tank or bag containing multiple doses of a fluid to be nebulized, and an indicator device for counting or indicating a number of uses performed or still possible with the reservoir, where at least one of: the reservoir includes a connector for fluidically connecting the tank or bag with the nebulizer, the indicator device is actuated by moving the connector relative to the tank or bag, and the reservoir includes or forms an eccentrical linear guidance for a driving part for driving the indicator device. 1313. A reservoir () for a nebulizer () , the reservoir () comprising:{'b': ['4', '2'], '#text': 'a tank or bag () containing multiple doses of a fluid () to be nebulized, and'}{'b': ['51', '3'], '#text': 'an indicator device () for counting or indicating a number of uses performed or still possible with the reservoir (), wherein at least one of:'}{'b': ['3', '6', '4', '1'], '#text': 'the reservoir () comprises a connector () for fluidically connecting the tank or bag () with the nebulizer (), wherein:'}{'b': ['51', '6', '4'], '#text': 'the indicator device () is actuated by moving the connector () relative to the tank or bag (), and'}{'b': ['3', '60', '51'], '#text': 'the reservoir () comprises or forms an eccentrical linear guidance for a driving part () for driving the indicator device ().'}2. The reservoir according to claim 1 , wherein at least one of:{'b': ['51', '3', '3'], '#text': 'the indicator device () comprises or forms a first axial end and/or a bottom of the reservoir () and is actuated from a second axial end and/or a top of the reservoir (), and'}{'b': ['6', '3'], '#text': 'the connector () comprises or forms a second axial end and/or the top of the reservoir ().'}3. The reservoir according to claim 1 , wherein at least one of:{'b': ['3', '5', '4', '1'], '#text': 'the reservoir () comprises a flexible fluid connection () for fluidically connecting the tank or bag () to the nebulizer (),'}{'b': ['5', '5', '4'], ...

ASSEMBLY FOR NASAL DISPENSING OF FLUID PRODUCT

A dispenser assembly comprising a nasal fluid dispenser device having a reservoir forming body () containing fluid or that supports such a reservoir in stationary manner, a dispenser head () being assembled on said body (), said dispenser head () being provided with a dispenser orifice (), said assembly further comprising a positioner member () that co-operates with said nasal dispenser device, said positioner member () including at least a first facial bearing zone () that, during actuation, co-operates with the forehead or the bridge of the user's nose, said dispenser head () being movable axially relative to said body (), said positioner member () including at least one hollow sleeve () in which said dispenser head () is inserted in clamping manner, said positioner member () including a second facial bearing zone () that is adapted to co-operate with the user's top lip. 1. A dispenser assembly comprising a nasal fluid dispenser device having a reservoir forming body containing fluid or that supports such a reservoir in stationary manner , a dispenser head being assembled on said body , said dispenser head being provided with a dispenser orifice , said assembly further comprising a positioner member that co-operates with said nasal dispenser device , said positioner member including at least a first facial bearing zone that , during actuation , co-operates with the forehead or the bridge of the user's nose , the assembly being characterized in that said dispenser head is movable axially relative to said body , said positioner member including at least one hollow sleeve in which said dispenser head is inserted in clamping manner , said positioner member including a second facial bearing zone that is adapted to co-operate with the user's top lip.2. An assembly according to claim 1 , wherein said positioner member includes two hollow sleeves claim 1 , each adapted to a respective nostril.3. An assembly according to claim 1 , wherein said positioner member includes ...

Nasal drug delivery device

A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.

Washing Water Spraying Vessel for Nasal Cavity Cleaner

The present invention relates to a washing water spraying vessel for a nasal cavity cleaner. A pumping operation of a pumping member is performed only when a pair of buttons formed on both sides of an outer cap are simultaneously pressed, which allows enabling fundamentally blocking the pumping operation through external pressure unintended by a user, thereby not only preventing washing water from being unnecessarily consumed but also preventing an inner part of the overcap from being contaminated.

UNIT DOSES, AEROSOLS, KITS, AND METHODS FOR TREATING HEART CONDITIONS BY PULMONARY ADMINISTRATION

Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also contemplated. 1. A method of treating atrial arrhythmia comprising administering a pharmaceutical composition via inhalation to a subject in need thereof , said pharmaceutical composition comprising a therapeutically effective amount of an antiarrhythmic agent , wherein said antiarrhythmic agent is selected from the group consisting of: class I , class II , class III , and class IV antiarrhythmics , a salt and a solvate thereof , and any combination thereof , and wherein a concentration of said antiarrhythmic agent in said pharmaceutical composition is about 20 to about 60 mg/mL.2. The method of claim 1 , wherein said therapeutically effective amount of said antiarrhythmic agent has a maximum ΔQRS of from about 1 to about 100 msec in said subject as measured by electrocardiography.3. The method of claim 3 , wherein said maximum ΔQRS is from about 3 to about 20 msec.4. The method of claim 1 , wherein said therapeutically effective amount of said antiarrhythmic agent has said maximum ΔQRS same as or greater than a maximum ΔQRS achieved by a second amount of said antiarrhythmic agent when administered intravenously to said subject as measured by electrocardiography claim 1 , wherein said therapeutically effective amount is less than half of said second amount.5. The method of claim 1 , wherein said concentration of said antiarrhythmic agent is about 30 to about 50 mg/mL.6. The method of claim 1 , wherein said concentration of said antiarrhythmic agent is about 45 mg/mL.7. The method of claim 1 , wherein said concentration of said antiarrhythmic agent is 45 mg/mL.8. The method of claim 1 , wherein said pharmaceutical composition comprises about 60 to about 130 mg of said antiarrhythmic agent.9. The method of claim 1 , wherein said therapeutically effective ...

Cartridge for substance delivery module

A substance delivery module ( 4 ) and apparatus ( 2 ) for delivering substance in aerosol form are disclosed. The substance delivery module ( 4 ) comprises a plurality of substance containers ( 90 ) and a plurality of pistons ( 76 ), with each substance container ( 90 ) being mounted in the module for cooperation with a dedicated piston ( 76 ). Another substance delivery module ( 4 ) is disclosed comprising a piston ( 76 ) defining a delivery axis ( 150 ) and a substance container ( 90 ), moveably mounted with respect to the piston ( 76 ). The substance container ( 90 ) is moveable along the delivery axis ( 150 ) and may for example be moved towards and onto the piston ( 76 ). Either of the substance delivery modules ( 4 ) may be assembled with an aerosol generator ( 10 ) and an aerosol delivery conduit ( 14 ) in fluid communication with the aerosol generator ( 10 ) to form an apparatus ( 2 ) for delivering substance in aerosol form. The apparatus ( 2 ) may further comprise a control module ( 6 ).

METHOD FOR PRODUCING A CARTRIDGE

A method for producing a cartridge is proposed, where a fluid is filled into an opening of a container and a closure part is inserted into the container, thereby moving a movable piston arranged within the container.

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 2. The method of claim 1 , wherein the opioid of Formula (I) is selected from the group consisting of fentanyl claim 1 , 2 claim 1 ,5-dimethylfentanyl claim 1 , 3-allylfentanyl claim 1 , 3-methylbutyrfentanyl claim 1 , 3-methylfentanyl claim 1 , 3-methylthiofentanyl claim 1 , 4-fluorobutyrfentanyl claim 1 , p-chloroisobutyrfentanyl claim 1 , p-fluoroisobutyrfentanyl claim 1 , 4-fluorofentanyl claim 1 , 4-phenylfentanyl claim 1 , 4-methoxybutyrfentanyl claim 1 , acrylfentanyl claim 1 , α-methylacetylfentanyl claim 1 , α-methylbutyrfentanyl claim 1 , α-methylfentanyl claim 1 , α-methylthiofentanyl claim 1 , acetylfentanyl claim 1 , alfentanyl claim 1 , benzylfentanyl claim 1 , β-hydroxyfentanyl claim 1 , β-hydroxythiofentanyl claim 1 , β-methylfentanyl claim 1 , butyrfentanyl claim 1 , brifentanyl claim 1 , carfentanyl claim 1 , cyclopentylfentanyl claim 1 , isobutyrfentanyl claim 1 , furanylfentanyl claim 1 , furanylethylfentanyl claim 1 , lofentanyl claim 1 , N-methylcarfentanyl claim 1 , methoxyacetylfentanyl claim 1 , mirfentanyl claim 1 , ocfentanyl claim 1 , ohmefentanyl claim 1 , R-30490 claim 1 , remifentanil claim 1 , sufentanyl claim 1 , thenylfentanyl claim 1 , thiofentanyl claim 1 , trefentanyl claim 1 , and valerylfentanyl.3. The method of claim 1 , wherein the spray is delivered as a round plume with an ovality ratio less than about 1.5 when measured at 3 cm.4. The method of claim 3 , wherein the pharmaceutical solution further comprises between about 0.2% and about 1.2% (w/v) of an isotonicity agent.5. The method of claim 4 , wherein the pharmaceutical solution further comprises between about 0.005% and about 0.015% (w/v) of a preservative.6. The method of claim 5 , wherein the ...

Nebulizer

A nebulizer for a fluid, includes a container containing the fluid; a housing part which can be detached from the nebulizer for replacing the container; an inner part; a retaining element connected with and not detachable from the inner part, where the housing part is releasable fixed to the inner part by the retaining element; a delivery mechanism for dispensing the fluid; a manually depressible actuator member, which is a separate part from the retaining element and acts on the retaining element, and wherein the actuator member is depressed to elastically deform or flex the retaining element to allow detachment of the housing part. 112. A nebulizer () for a fluid () , comprising:{'b': 3', '2, 'a container () containing the fluid ();'}{'b': 18', '1', '3, 'a housing part () which can be detached from the nebulizer () for replacing the container ();'}{'b': '17', 'an inner part ();'}{'b': 19', '17', '18', '17', '19, 'a retaining element () connected with and not detachable from the inner part (), wherein the housing part () is releasable fixed to the inner part () by the retaining element ();'}{'b': '2', 'a delivery mechanism for dispensing the fluid (); and'}{'b': 79', '19', '19, 'a manually depressible actuator member (), which is a separate part from the retaining element () and acts on the retaining element (),'}{'b': 79', '19', '18, 'wherein the actuator member () is depressed to elastically deform or flex the retaining element () to allow detachment of the housing part ().'}2183. The nebulizer according to claim 1 , wherein the housing part () forms a cap-like lower housing part and fits around or over a lower free end portion of the container().319181. The nebulizer according to claim 1 , wherein the retaining element () forms a catch or snap for automatically holding or securing the housing part () when it is shifted onto or into the nebulizer ().41882198319. The nebulizer according to claim 1 , wherein the housing part () comprises a holding portion () for ...

IMPROVED VALVE

Inhalation device for generation of an aerosol of a medically active liquid, said inhalation device comprising a check valve (); a housing (), inside this housing () a reservoir () for storing said medically active liquid (L), downstream this reservoir () a pumping unit () for generation of a pressure connected to a means for the delivery of mechanical energy () to said pumping unit (), and downstream said pumping unit () a nozzle (); wherein the pumping unit () comprises a hollow cylindrical part (A) and a piston (B), the cylindrical part (A) having an interior space (C) configured to receive an end portion (B′) of said piston (B), wherein said cylindrical part (A) and said piston (B) are linearly moveable relative to one another such as to form a pumping chamber (D) having a variable volume. 1. Inhalation device for the generation of an aerosol of a medically active liquid and for the inhalative administration of the aerosol of said medically active liquid , said inhalation device comprising:a housing, inside this housing a reservoir for storing said medically active liquid, downstream this reservoir a pumping unit for generation of a pressure connected to a means for the delivery of mechanical energy to said pumping unit, and downstream said pumping unit a nozzle;wherein the pumping unit comprises a hollow cylindrical part and a piston, the cylindrical part having an interior space configured to receive an end portion of said piston, wherein said cylindrical part and said piston are linearly moveable relative to one another such as to form a pumping chamber having a variable volume;the inhalation device further comprising a check valve such as to allow liquid flow in the downstream direction and prevent liquid flow in the opposite direction, the valve comprising a moveable body and a seat arranged upstream the body, the seat being arranged at a downstream opening of a hollow seat extension section having an upstream opening, and whereinthe check valve's body ...

Ventilator circuit, adapter for use in ventilator circuit and methods for the use thereof

An adapter includes a housing having an inlet port defining a flow path and an outlet port. An interior wall has an inner surface defining an interior passageway communicating with the outlet port and an exterior surface defining an exterior passageway communicating with the inlet port. The interior wall defines a mouth communicating between the interior and the exterior passageways. The interior wall is positioned transverse to the flow path of the inlet port. A medicament delivery port opens into the mouth. A valve is moveable between a closed position, wherein the valve closes the medicament delivery port, and an open position, wherein the medicament delivery port is open. A ventilator circuit and method of delivering a medicament are also provided.

Multi Surface Acoustic Nebuliser

A nebuliser for nebulising liquid droplets includes a housing; at least one piezoelectric substrate accommodated within the housing and having a transducer surface upon which is located at least one electroacoustic transducer for generating acoustic wave energy within the substrate, and an opposing non-transducer surface; and a liquid supply system for supplying a liquid to at least one of the transducer and non-transducer surfaces. The liquid supply system includes a reservoir for accommodating the liquid, and at least one relatively rigid supply conduit in contact with the substrate for supplying the liquid from the reservoir to the substrate. 1. A nebuliser for nebulising liquid droplets , including: at least one piezoelectric substrate accommodated within the housing and having a transducer surface upon which is located at least one electroacoustic transducer for generating acoustic wave energy within the substrate, and an opposing non-transducer surface; and', 'a liquid supply system for supplying a liquid to at least one of the transducer and non-transducer surfaces, the liquid supply system including a reservoir for accommodating the liquid, and at least one relatively rigid supply conduit in contact with the substrate for supplying the liquid from the reservoir to the substrate., 'a housing;'}2. A nebuliser according to claim 1 , therein the supply conduit is in the form of a nib or needle.3. A nebuliser according to or claim 1 , wherein the supply conduit is formed from an acoustically reflecting material.4. A nebuliser according to any one of the preceding claims claim 1 , wherein the liquid is gravity fed from the reservoir through the supply conduit.5. A nebuliser according to any one of to claim 1 , wherein the liquid is transferred from the reservoir through an active pumping system.6. A nebuliser according to claim 5 , wherein the active pumping system is a syringe or peristaltic pump.7. A nebuliser according to any one of the preceding claims claim 5 ...

COMBINED LARYNO-TRACHEAL ANESTHETIC AND STYLET DEVICE

A device for delivering medication is presented. The device has a conduit with an upstream end and a downstream end. The downstream end of the conduit delivers the medication. The device has a housing with an open end and an end forming a flat substrate. The housing receives a syringe containing medication and having a plunger. The device also has mechanism for releasing the medication from the syringe and a mechanism for pressurizing the medication. The device has a connector from providing a connection between the syringe and the upstream end of the conduit. 1. A medication delivery device , the device comprising:a conduit with an upstream end and a downstream end, wherein the downstream end is designed to deliver medication, and wherein the conduit is malleable such that it can be reversibly deformed into a shape that facilitates intubation;a housing with a first end and a second end, wherein the first end is open and the second end form a flat substrate and wherein the housing is adapted to receive a syringe, the syringe containing a medication and having a plunger;a releasing mechanism for releasing the medication from the syringe;a pressurizing mechanism for pressuring the medication; anda connector that provides fluid communication between the syringe and the upstream end of the conduit through the flat substrate.2. The medical device of claim 1 , wherein the connector is a luer connector.3. The device of claim 1 , further comprising a nozzle claim 1 , wherein the nozzle having a proximal end and a distal end and wherein the proximal end of the nozzle is in fluid communication with the downstream end of the conduit claim 1 , wherein the distal end of the nozzle is blunted claim 1 , and wherein the nozzle is capable of functioning as an introducer.4. The device of claim 3 , wherein the distal end of the nozzle has a cone claim 3 , wherein the cone having an inner surface and an outer surface claim 3 , wherein the cone contains baffles on the outer surface of ...

MODULAR DEVICE FOR CELL SPRAYING

Systems and methods for spraying a liquid treatment solution can include a syringe attachment device and a handheld device, which are configured to be coupled together in an assembled position of the system. The syringe attachment device can be configured to secure a syringe containing the liquid treatment solution. In an example, the treatment solution can include autologous skin cells for treating a tissue wound. The handheld device can have a movable slide configured to dispense the treatment solution from the syringe. In an example, the spray deposition system can include a cover positioned to provide an impervious barrier between at least a portion of the syringe attachment device and the handheld device. The cover can be attached to the syringe attachment device prior to coupling the devices together. In an example, the cover can have a generally tubular shape with a closed end and an open end. The handheld device can be inserted into the cover and the cover can enclose the handheld device in the assembled position. In an example, the cover can be sterile and at least a portion of the syringe attachment device can be sterile. In an example, after delivery of the treatment solution, the syringe attachment device can be disposed of and the handheld device can be reused. 1. A spray deposition system , comprising: a needle adjacent a syringe channel, the syringe channel configured to receive a syringe; and', 'a tube having a discharge end proximate a delivery end of the needle, the tube configured to deliver an air flow;, 'a syringe attachment device having a base with a coupling portion, the syringe attachment device comprisinga handheld device configured to be coupled to the coupling portion of the syringe attachment device in an assembled position of the system and control delivery of a treatment solution from the syringe; anda sterile cover coupled to the syringe attachment device to provide an impervious barrier between at least a portion of the syringe ...

AEROSOL GENERATING ASSEMBLY

An aerosol generating assembly is disclosed, which includes a heater assembly including, a heater body extending in a longitudinal direction, and at least one heater in the heater body; a capillary tube extending longitudinally through at least a portion of the heater body, the capillary tube in fluid communication with a reservoir, the at least one heater configured to heat the capillary tube; a thermocouple in the heater body; and a temperature controller configured to control a heating temperature. 1. An aerosol generating assembly comprising: a heater body extending in a longitudinal direction, and', 'at least one heater in the heater body;, 'a heater assembly including,'}a capillary tube extending longitudinally through at least a portion of the heater body, the capillary tube in fluid communication with a reservoir, the at least one heater configured to heat the capillary tube;a thermocouple in the heater body; anda temperature controller configured to control a heating temperature.2. The aerosol generating assembly of claim 1 , wherein the heater body comprises:an upper assembly; anda lower assembly configured to mate with the upper assembly.3. The aerosol generating assembly of claim 2 , wherein the upper assembly and the lower assembly define at least one longitudinally extending bore.4. The aerosol generating assembly of claim 3 , wherein the at least one heater is in the at least one longitudinally extending bore.5. The aerosol generating assembly of claim 2 , wherein the upper assembly claim 2 , the lower assembly claim 2 , or both the upper assembly and the lower assembly are formed of a thermally conductive material.6. The aerosol generating assembly of claim 1 , wherein the at least one heater comprises:a heater cartridge.7. The aerosol generating assembly of claim 1 , wherein the capillary tube has an inner diameter of about 0.05 millimeters to about 0.53 millimeters.8. The aerosol generating assembly of claim 1 , wherein the capillary tube has a ...

Device for dispensing a fluid product, and method for filling and for plugging same

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

SUBSTANCE DELIVERY MODULE

A substance delivery module () and apparatus () for delivering a substance in aerosol form are disclosed. The substance delivery module () comprises a substance container (), a piston () and an actuator () configured to engage the substance container () and urge the substance container () onto the piston (), so dispensing the substance into the through passage () of the piston. The actuator () and substance container () are mounted in the substance delivery module () for relative motion, such relative motion bringing the actuator () into engagement with the substance container (). The substance delivery module () may be assembled with an aerosol generator () and an aerosol delivery conduit () to form an apparatus () for delivering a substance in aerosol form. The apparatus () may further comprise a control module (). 1. A substance delivery module comprising:a piston;a substance container axially aligned with the piston; andan actuator, configured to engage the substance container and urge the substance container onto the piston, wherein the actuator and substance container are mounted in the module for relative motion of the actuator with respect to the substance container, such motion bringing the actuator into axial alignment with the piston and substance container and into engagement with the substance container, forcing the substance container onto the piston.2. A module as claimed in claim 1 , wherein the piston is dimensioned to displace an internal volume of the substance container.3. A module as claimed in claim 1 , wherein the piston comprises a passage extending therethrough.4. A module as claimed in claim 3 , wherein the piston comprises a cutting element claim 3 , mounted on a leading surface of the piston.5. A module as claimed in claim 4 , wherein the cutting element is disposed about a leading opening of the piston passage.6. A module as claimed in claim 4 , wherein the piston further comprises a second cutting element mounted about a rim of the ...

DEVICES AND METHODS FOR PROTECTING THE EYE FROM ADJACENT SKIN TREATMENTS

A skin care apparatus suitable for use in proximity to a subject's eyes. The apparatus includes a treatment device and a stimulus device. Upon activation by a user, such as the subject or a technician, a stimulus delivered by the stimulus device causes the subject's eyelid to close prior to the administration of a skin care treatment by the treatment device. 1. A method for treating an area adjacent a subject's eye with a skin care apparatus , the skin care apparatus having a treatment switch , a stimulator , and a treatment head , the method comprising:activating the treatment switch; generating the puff of air with the stimulator, and', "delivering the puff of air through a treatment head at the subject's eye sufficient to close the subject's eye via reflex; and"], "administering a puff of air at the subject's eye based on activation of the treatment switch, wherein administering the puff of air includes:"}after said administering the puff of air at the subject's eye, administering a treatment with the treatment head to the area adjacent the subject's eye.2. The method of claim 1 , wherein administering the treatment includes:administering a chemical treatment from an internal reservoir.3. The method of claim 2 , wherein administering the treatment includes:administering the chemical treatment with a chemical spray pump.4. The method of claim 1 , wherein administering the puff of air includes:administering the puff of air for a duration of 80 milliseconds or longer.5. The method of claim 1 , wherein administering the treatment includes:administering the treatment at least 80 milliseconds after initiation of stimulus administration.6. The method of claim 1 , wherein generating the puff of air with the stimulator includes:generating the puff of air from the stimulator, wherein the stimulator is selected from a group consisting of a fan, a blower, a piston, a piezoelectric fan, a pump, and a source of compressed gas.7. The method of claim 1 , wherein administering ...

Method and Apparatus for Irrigation

Disclosed is an irrigation system. The irrigation system includes a manual pump and refill. The manual pump can provide pressurized liquid through a tube at an outlet. 1. A system for irrigation of a selected location , comprising:a container configured to contain a selected volume of a liquid;a manual pump system having a pump volume, wherein the manual pump is configured to be powered and operated by a user;a first one-way valve configured to control flow from the container to the pump volume;a tip having an opening to deliver a selected pressure spray to a surface; anda second one-way valve configured to control flow from the pump volume to the tip;wherein the pump is configured to be reciprocally operated by the user to irrigate the selected location with the liquid through the tip.2. The system of claim 1 , wherein the manual pump includes a syringe having:a piston head and a piston rod moveable within the pump volume; anda syringe barrel forming the pump volume;wherein the user moves the piston head with the piston rod to power and operate the manual pump.3. The system of claim 2 , further comprising:a valve assembly including the first one-way valve and the second one-way valve;wherein the valve assembly is coupled to the syringe barrel;wherein the first one-way valve opens when the piston head moves in a first direction and the second one-way valve opens when the piston head moves in a second direction.4. The system of claim 2 , further comprising:a valve assembly including the first one-way valve and the second one-way valve;wherein the valve assembly is coupled to the syringe barrel;wherein the first one-way valve opens when the piston head moves in a first direction to form a vacuum in the syringe barrel and the second one-way valve opens when the piston head moves in a second direction to increase pressure in the valve assembly.5. The system of claim 1 , wherein the opening of the tip has a cross-sectional area ratio relative to a cross-sectional area of ...

Method and Apparatus for Irrigation

Disclosed is an irrigation system. The irrigation system includes a manual pump. The manual pump can provide pressurized liquid through a tube at an outlet. 1. A system for irrigation of a selected location , comprising:a manual pump assembly having a pump barrel forming a volume;a fluid source fluidly connected to the pump barrel;a tip having an opening to deliver a selected pressure spray to a surface;a valve assembly configured to control flow from the fluid source to the pump barrel and from the pump barrel to the tip; andwherein the manual pump is configured to be powered and operated by a user to at least express material from the pump barrel;wherein the manual pump is configured to be reciprocally operated by the user to irrigate the selected location with a fluid through the tip.2. The system of claim 1 , further comprising:a plunger moveable within the pump barrel between a first barrel end and a second barrel end;a biasing system to apply a biasing force to bias the plunger towards the first barrel end;wherein the user overcomes the biasing force of the biasing system to irrigate the selected location by moving the plunger towards the second barrel end.3. The system of claim 1 , wherein the valve assembly includes:a first one-way valve configured to control flow from the fluid source to the pump barrel; anda second one-way valve configured to control flow from the pump barrel to the tip.4. The system of claim 3 , wherein the valve assembly is coupled directly to the pump barrel;wherein the first one-way valve opens when the plunger moves toward a first pump barrel end and the second one-way valve opens when the plunger moves toward a second pump barrel end.5. The system of claim 1 , wherein the opening of the tip has a cross-sectional area ratio relative to a cross-sectional area of a tubing extending from the pump volume of about 1:1 to about 1:10 claim 1 ,000.6. The system of claim 1 , further comprising:a tip tube, wherein the tip extends from a ...

Container, nebulizer and use

A container, a nebulizer and a use of an indicator device are described, where the container comprises an indicator device fixedly mounted on the bottom of the container, the container is arranged within the nebulizer and the container can be detached by grabbing the indicator device.

NICOTINE DELIVERY SYSTEM

A nicotine delivery system is disclosed. The nicotine delivery system comprises an actuating mechanism and a housing that has a longitudinal axis and defines a chamber that is configured to receive a plunger and has an outlet for the passage of formulation out of the chamber. The actuating mechanism comprises an actuator and an actuation member. The actuator cooperates with the actuation member such that when a plunger is received in the chamber the plunger and the chamber slide relative to each other in an axial direction by a predetermined incremental distance upon each operation of the actuator to displace a predetermined volume of formulation from the chamber through said outlet. 1. A nicotine delivery system comprising:a housing that has a longitudinal axis and which defines a chamber that is configured to receive a plunger and has an outlet for the passage of a formulation out of the chamber; andan actuating mechanism comprising an actuator and an actuation member;wherein the actuator cooperates with the actuation member such that when the plunger is received in the chamber the plunger and the chamber slide relative to each other in an axial direction by a predetermined incremental distance in response to each operation of the actuator by a user to displace a predetermined volume of the formulation from the chamber through the outlet.220-. (canceled)21. The nicotine delivery system according to claim 1 , further comprising a screw thread configured to translate rotation of the actuation member in a rotational direction into displacement of the actuation member in an axial direction.22. The nicotine delivery system according to claim 21 , further comprising a mating portion held in a fixed position relative to the axial direction claim 21 , and wherein the screw thread is disposed on the actuation member and is configured to cooperate with the mating portion.23. The nicotine delivery system according to claim 21 , further comprising a mating portion disposed on ...

Medicament delivery device for administration of opioid antagonists including formulations for naloxone

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH-adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

Rhinovaccination system of influenza vaccine

The present invention relates to a rhinovaccination system of influenza vaccine, comprising a medical syringe filled with an influenza vaccine composition which comprises an inactivated whole influenza virion and a gel base material comprising carboxy vinyl polymer to administer the influenza vaccine composition to nasal mucosa, which is characterized by not comprising an adjuvant.

Rhinal Spray Nozzle used for Medical Syringe

The present invention has a purpose to achieve desired spray characteristics when a pharmaceutical formulation is sprayed by means of a rhinal spray nozzle used for a metered-dose syringe-based squirt. 1. A rhinal spray nozzle used for a medical syringe having a tip opening in fluid communication with a syringe barrel for storing a formulation , the rhinal spray nozzle comprising:a hollow nozzle body having a tip portion defining a nozzle orifice thereon;a solid packing rod arranged within the nozzle body; anda nozzle chamber defined between the packing rod and the nozzle body to allow a fluid communication between the tip opening and the nozzle orifice;wherein the formulation comprises the gel material containing viscosity modification agent and carboxy vinyl polymer of which viscosity is modified by applying an exogenous shear force, andwherein the nozzle orifice has a diameter in a range between 0.25 mm and 0.30 mm.2. The rhinal spray nozzle according to claim 1 , wherein the formulation comprises the gel material containing an electrolyte as the viscosity modification agent which is selected from a group consisting of sodium chloride claim 1 , potassium chloride claim 1 , dibasic sodium phosphate hydrate claim 1 , and sodium dihydrogenphosphate claim 1 , of which viscosity is modified by applying an exogenous shear force.3. The rhinal spray nozzle according to claim 1 , wherein the nozzle orifice includes substantially no curved portion.4. The rhinal spray nozzle according to claim 1 , wherein the tip portion has thickness along an injection direction of the formulation which is in a range between 0.20 mm and 0.30 mm.5. The rhinal spray nozzle according to claim 1 ,wherein the nozzle body includes an inner wall having at least a portion formed in a cylindrical shape and the packing rod includes an outer wall at least a portion formed in a cylindrical shape having a plurality of circumferentially spaced grooves,wherein the nozzle chamber is defined between the at ...

NOVEL OPERATED NEBULIZER AND MEANS THEREOF

A process and a nebulizer for dispensing a consecutively dose of medicament in the form of a mist, comprising: an energy source (ES), an air-conditioning volume, an air outlet fluidity connected to the air-containing volume, an air actuator adapted to release a flow of compressed air through the air outlet at such time as a predetermined ES pressure has been reached in the volume and at least two valve means in communication with the air actuator. The compressed air is released at a predetermined pressure of about 20 to about 100 psig. The valve means controls the actuation of the air actuator such that when a medication is nebulized, a mist distribution of a medication is formed having droplets size in the range of approximately 1μ to approximately 7μ which inhaled by a user at a set of predetermined intervals. 156-. (canceled)57. A nebulizer for dispensing a consecutively dose of a medicament in the form of a mist , comprising:a. an energy source (ES) comprising at least one of the following: LG source, electric motor, electric linear actuator, electromagnetic solenoid based actuator, spring operated mechanism, hydraulic pump, compressed gas (CG), flywheel, steam engine, carrot machine, stirling cycle;b. an air-containing volume;c. an air outlet fluidly connected to said air-containing volume; andd. an air actuator in communication with at least two valve means, said air actuator being adapted to release a flow of compressed air from the air-containing volume through said air outlet by application of force from the energy source at such time as a predetermined pressure has been reached in said air-containing volume, thereby providing continuous release of predetermined amount of medication droplets.58. The nebulizer system according to claim 57 , wherein said ES comprises the LG source claim 57 , the system further comprising an LG outlet and an LG containing volume fluidly connected to the LG source and being adapted to contain LG.59. The nebulizer system ...

SYSTEM WITH NEBULIZER AND CONTAINER

A system with a nebulizer as well as a container with a fluid and an indicator device for such a nebulizer are proposed. A check scheme is used for indicating the number of containers already used with the nebulizer or which still can be used with the nebulizer. The indicator device indicates the number of uses performed or still possible with the current container. The indicator device is adapted to let stepwise appear a color sequence and/or replacement symbol when approaching a predetermined number of uses with the container. Further, the indicator device can show markings in braille. 11002. A system () for nebulizing a fluid () , comprising:{'b': 1', '3', '2, 'a nebulizer () for receiving a replaceable container () containing a fluid ();'}characterized in{'b': 100', '75', '3, 'that the system () comprises a check scheme () for marking the number of containers () already used or which still can be used.'}27511. The system according to claim 1 , characterized in that the check scheme () is attached to the nebulizer () or inseparable from the nebulizer ().375171. The system according to claim 1 , characterized in that the check scheme () is attached to or formed on a housing part () of the nebulizer ().47578. The system according to claim 1 , characterized in that the check scheme () is formed on or by a label ().578798021. The system according to claim 4 , characterized in that the label () comprises in addition information () or at least one symbol () about the fluid () or use or handling of the nebulizer ().675. The system according to claim 1 , characterized in that the check scheme () is made to be marked by writing or scratching or by preferably partial removal or piercing.775763. The system according to claim 1 , characterized in that the check scheme () comprises multiple check boxes () for marking claim 1 , or each time a container () is connected or replaced.817575. The system according to claim 1 , characterized in that the nebulizer () comprises a ...

Nebulizer and container

A nebulizer as well as a container with a fluid for such a nebulizer are proposed. The container comprises a control device which indicates initially an unused state of the container before first use. An indicator device stops via a locking device further use of the container in a locked state when a predetermined number of uses has been reached or exceeded. After replacement of the container, the nebulizer can be reset and used again.

AEROSOL DELIVERY DEVICE INCLUDING A BUBBLE JET HEAD AND RELATED METHOD

The present disclosure relates to aerosol delivery devices. The aerosol delivery devices include mechanisms configured to deliver an aerosol precursor composition from a reservoir to an atomizer including a vaporization heating element to produce a vapor. For example, a bubble jet head may be configured to dispense the aerosol precursor composition to the atomizer. The bubble jet head may be fixedly coupled to the atomizer. The bubble jet head may include a precursor inlet, an ejection heating element, and a precursor nozzle. The atomizer may include a vaporization heating element. 130-. (canceled)31. An aerosol delivery device , comprising:a reservoir at least partially filled with an aerosol precursor composition;a bubble jet head in fluid communication with the reservoir, the bubble jet head being configured to dispense the aerosol precursor composition from the reservoir; andan atomizer configured to heat the aerosol precursor composition dispensed by the bubble jet head to produce an aerosol,wherein the aerosol precursor composition is initially prevented from traveling to at least one of the atomizer and the bubble jet head, and wherein the aerosol delivery device is configured to permit traveling of the aerosol precursor composition toward the atomizer and/or bubble jet head in response to an input.32. The aerosol delivery device of claim 31 , wherein the bubble jet head comprises a precursor nozzle claim 31 , and wherein the precursor nozzle is sized so as to resist travel therethrough of the aerosol precursor composition such that the aerosol precursor composition is initially prevented from traveling to the atomizer.33. The aerosol delivery device of claim 31 , wherein the bubble jet head comprises a plurality of precursor nozzles claim 31 , and wherein the plurality of precursor nozzles are sized so as to resist travel therethrough of the aerosol precursor composition such that the aerosol precursor composition is initially prevented from traveling to the ...

FLUID PRODUCT DISPENSING DEVICE

A fluid dispenser device having a body () with a dispenser orifice () and a perforator element (), the body containing a reservoir () with at least two doses of fluid and having a proximal axial opening closed by a membrane () and a distal axial opening closed by a piston () to dispense one dose of fluid on each actuation. The reservoir is axially movable relative to the body between a rest position in which said perforator element does not pass through the membrane and a dispensing position in which the perforator element passes through the membrane. A perforator spring () is provided to urge the reservoir towards the rest position, and the membrane is adapted to close after each actuation, when said perforator element withdraws from the reservoir. 1. A fluid dispenser device comprising: a body that is provided with a dispenser orifice and with a perforator element , said body containing a reservoir that contains at least two doses of fluid , said reservoir including a proximal axial opening that is closed by a membrane , and a distal axial opening that is closed by a piston that is slidably mounted in said reservoir so as to dispense one dose of fluid on each actuation , the dispenser device being characterized in that said reservoir is axially movable relative to said body between a rest position in which said perforator element does not pass through said membrane , and a dispensing position in which said perforator element passes through said membrane , a perforator spring being provided between said body and said reservoir , so as to urge said reservoir towards its rest position , said membrane being adapted to close in leaktight manner after each actuation , when said perforator element withdraws from said reservoir.2. A device according to claim 1 , wherein said membrane is formed as a structure comprising at least two layers made out of different materials.3. A device according to claim 2 , wherein said membrane includes an inner layer that is made out of ...

DISCHARGE HEAD FOR A DISPENSER FOR DISCHARGING A FLUID AND DISPENSER COMPRISING A DISCHARGE HEAD OF THIS TYPE AND SECURING SECTION FOR A DISCHARGE HEAD OF THIS TYPE

A discharge head for a dispenser including a base and an applicator mounted movably thereon. The base is fitted onto a liquid reservoir or is rigidly integrated on a liquid reservoir. The applicator includes a discharge opening through which liquid is released into an environment. The discharge head includes a pump mechanism or a valve mechanism arranged in a liquid channel connecting the liquid reservoir to the discharge opening. The pump mechanism is actuated by displacement of the applicator relative to the base, or the valve mechanism is opened and closed by displacement of the applicator relative to the base. The discharge head includes a cap unit with a cap for covering the discharge opening and a separate securing portion mounted securely on the base or the applicator via a securing mechanism and is designed to secure the cap releasably. 1. A discharge head for a dispenser for discharging a liquid , in particular for discharging a pharmaceutical or cosmetic liquid , with the features:a. the discharge head comprises a base and an applicator mounted movably on the base, andb. the base is designed to be fitted onto a liquid reservoir or to be rigidly integrated on a liquid reservoir, andc. the applicator comprises a discharge opening through which liquid can be released into an environment, andd. the discharge head comprises a pump mechanism or a valve mechanism, which is arranged in a liquid channel connecting the liquid reservoir to the discharge opening, wherein the pump mechanism can be actuated by displacement of the applicator with respect to the base, or wherein the valve mechanism can be opened and closed by displacement of the applicator with respect to the base,wherein:e. the discharge head comprises a childproof cap unit, andf. the cap unit comprises a cap for covering the discharge opening, andg. the cap unit comprises a separate securing portion which, on the one hand, is mounted securely on the base or the applicator via a securing mechanism and, ...

VALVED CONTAINER ASSEMBLY

A valved container assembly () comprising a container () for containing a fluid, the container () extending in an axial direction and having at least one venting opening () at a front end and at least one dispensing opening (). The valved container assembly () further comprising a valve () disposed in the container () and a plunger element () disposed axially rearward of the valve (), the plunger element () being axially moveable in the container () and defining a first volume () in the container () between the plunger element () and the valve (), where the plunger element () is configured to increase the pressure of a fluid in the first volume () upon axial movement relative to the valve (). The valve () comprises a permanent seal () forming a fluidic seal between the at least one venting opening () and the first volume (), and a resilient seal () that is axially rearward of said permanent seal () and is moveable between a sealing configuration and an open configuration. In the sealing configuration the resilient seal () forms a fluidic seal with the container () between the at least one dispensing opening () and the first volume (). In at least one axial position of the valve () in the container () when the resilient seal () is in the open configuration the first volume () is fluidly connected to the at least one dispensing opening (). The resilient seal () is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume () exceeding a predetermined pressure threshold. 1. A valved container assembly comprising:a container for containing a fluid, the container extending in an axial direction and having at least one venting opening at a front end and at least one dispensing opening;a valve disposed in the container; anda plunger element disposed axially rearward of the valve, the plunger element being axially moveable in the container and defining a first volume in the container between the plunger element and the valve, ...