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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 5561. Отображено 100.
22-11-2012 дата публикации

Integrated delivery device for continuous glucose sensor

Номер: US20120296311A1
Автор: Apurv U. Kamath, Dubravka Markovic, James H. Brauker, Mark A. Tapsak, Michael Robert Mensinger, Paul V. Neale, Peter C. Simpson, Sean T. Saint
Принадлежит: Dexcom Inc

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

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Номер записи: 1
29-11-2012 дата публикации

Dispenser and method for entraining powder in an airflow

Номер: US20120298106A1
Автор: Johan Remmelgas, Marten Svensson, Orest Lastow, Per Arne Kjellgren
Принадлежит: AstraZeneca AB

The disclosure relates to a device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.

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Номер записи: 2
07-02-2013 дата публикации

Dose delivery device for inhalation

Номер: US20130032144A1
Автор: Andrew Miller, Richard L. Miller
Принадлежит: Manta Devices LLC

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

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Номер записи: 3
10-04-2014 дата публикации

Dose counters for inhalers, inhalers and methods of assembly thereof

Номер: US20140096769A1
Автор: Dan Buck, Declan Walsh, Derek Fenlon, Jan Geert Hazenberg, Jeffrey A. Kang, Paul Clancy, Robert Charles Uschold, Simon Kaar
Принадлежит: Norton Waterford Ltd

A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

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Номер записи: 4
06-01-2022 дата публикации

Device and method for aerosolized delivering of substance to a natural orifice of the body

Номер: US20220001118A1
Автор: Daniel Shahaf, David NAPCHI, Iris Shichor
Принадлежит: SIPNOSE Ltd

A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

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Номер записи: 5
07-01-2021 дата публикации

Remote smell technology

Номер: US20210000998A1
Автор: Guido Fridolin Verbeck
Принадлежит: University of North Texas

The present application relates to systems, methods, and computer-readable media for providing generating odors. In aspects, the disclosed methods may include generating, by a chemistry dispersion element, a signal configured to act upon a surface of a chemistry reservoir to disperse an odorous substance retained within the chemistry reservoir. The chemistry reservoir and the chemistry dispersion element may be disposed within a housing. The method also includes generating, by an air pump, a volume of air, and transporting, by an airflow pathway, the volume of air from the air pump to an air outlet. The volume of air passes through at least a portion of the housing as it flows through the airflow pathway from the air pump to the air outlet, and transports at least a portion of the odorous substance dispersed by the chemistry reservoir within the housing to the air outlet.

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Номер записи: 6
07-01-2016 дата публикации

LIQUID NEBULIZATION SYSTEMS AND METHODS

Номер: US20160001019A1
Автор: Casey Michael Joseph, Fink Jim, Grehan Joesph Martin, Hyland Kieran James, Lillis Claire Elizabeth, MacLoughlin Ronan, Molloy Lisa, Mullins John Matthew, Smith Niall Scott
Принадлежит:

Embodiments provide aerosolization device for providing aerosolized medicament to user. The aerosolization device includes conduit, aerosol generator, fluid receiving chamber, restrictor within the conduit, and indicator mechanism. Conduit has an inner wall and a mouthpiece end for causing an inspiratory flow. Aerosol generator includes a vibratable mesh laterally offset from the inner wall. Fluid receiving chamber receives liquid medicament. At least a portion of chamber is tapered such that liquid medicament is directed onto vibratable mesh for aerosolization. Restrictor defines a plurality of apertures that provide increases in pressure differential that vary with inspiratory flow rate within conduit and provide relatively laminar flow downstream of restrictor. Indicator mechanism indicates a state of flow parameters relative to a predefined range. Aerosol generator is configured to aerosolize at least a portion of liquid medicament only when flow parameters of the inspiratory flow are within range. 1. An aerosolization device for providing aerosolized medicament to a user , the aerosolization device comprising:a conduit having an inner wall and a mouthpiece end by which a user may cause an inspiratory flow through the conduit;an aerosol generator in communication with the conduit and comprising a vibratable mesh, the vibratable mesh laterally offset from the inner wall;a fluid receiving chamber in communication with the aerosol generator for receiving a volume of a liquid medicament, wherein at least a portion of the fluid receiving chamber is tapered such that substantially all of the liquid medicament is directed onto the vibratable mesh for aerosolization; and provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit; and', 'provide a relatively laminar flow downstream of the restrictor plate compared to upstream of the restrictor plate;, 'a restrictor disposed within the conduit, wherein the restrictor defines ...

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Номер записи: 7
04-01-2018 дата публикации

DRY POWDER DRUG DELIVERY SYSTEM AND METHODS

Номер: US20180001039A1
Автор: Adamo Benoit, Kinsey P. Spencer, Laurenzi Brendan F., Smutney Chad C.
Принадлежит:

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity. 1. A medicament cartridge comprising:a powder container;a lid; andan internal volume,wherein the lid includes a deflector or stem protruding from an undersurface facing the internal volume to direct airflow entering the internal volume from a direction parallel to the lid to a substantially downward direction to a direction substantially parallel to the lid to a direction substantially perpendicular to the lid to exit the powder container.2. The medicament cartridge of claim 1 , wherein the dry powder medicament cartridge is configured to include a containment configuration and a dosing configuration.3. The medicament cartridge of claim 2 , wherein in the containment configuration the dry powder is sealed from outside air.4. The medicament cartridge of claim 2 , wherein in the containment configuration the dry powder is sealed from the deflector or stem.5. The medicament cartridge of claim 1 , wherein the airflow exits the medicament cartridge through the lid.6. The medicament cartridge of claim 1 , wherein the medicament cartridge includes a dry powder.7. The medicament cartridge of claim 6 , wherein the dry powder comprises a diketopiperazine or a pharmaceutically acceptable salt thereof.8. The medicament cartridge of claim 7 , wherein the diketopiperazine is of the formula 2 claim 7 ,5-diketo-3 claim 7 ,6-bis(N—X-4-aminobutyl)piperazine claim 7 , wherein X is selected from the group consisting of ...

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Номер записи: 8
05-01-2017 дата публикации

DRY POWDER INHALATION DEVICE

Номер: US20170000960A1
Автор: RICHARDSON Eric Carl
Принадлежит: Concentrx Pharmaceuticals, Inc.

Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient. 1. An apparatus , comprising:a body having an upper portion and a lower portion, the body defining a toroidal disaggregation chamber, a bottom portion of the toroidal disaggregation chamber being within the lower portion and containing a dry powder drug;a removable partition disposed between the upper portion and the lower portion, the partition retaining the dry powder drug within the bottom portion of the toroidal disaggregation chamber when the upper portion and lower portion are coupled together;an air intake passage configured to place an external volume in fluid communication with the toroidal disaggregation chamber when the partition is removed; andan exit passageway configured to place the external volume in fluid communication with the toroidal disaggregation chamber when the partition is removed such that upon inhalation by the patient on the exit passageway, air is drawn from the air intake passage to the toroidal disaggregation chamber and on to the exit passageway to convey the dry powder drug via the exit passageway to a patient.2. A method of using a single-dose inhalation device to deliver a pre-metered dry powder drug , comprising:removing a protective overwrap packaging from the inhalation device;removing a partition of the inhalation device by pulling an end of the partition ...

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Номер записи: 9
02-01-2020 дата публикации

LIQUID ATOMIZING DEVICE

Номер: US20200001024A1
Автор: Chen Yu-Chi
Принадлежит: YI-JIN PROMOLD ENTERPRISE LTD.

A liquid atomizing device includes a medical solution cup connected to an air pump, and an output cover installed onto the medical solution cup and including an atomizing socket formed in the outer cover, and the top of the atomizing socket cover has a linear opening and a drainage groove for increasing the flow of a medical solution. When the medical solution is guided to flow upwardly through the drainage and sprayed from a specially designed linear opening to the outside through the drainage groove due to a high speed airflow, the medical solution is collided with a barrier rod disposed above the linear opening to form an atomized medical solution, and the linear opening has the effect of atomizing the medical solution stably. 1. A liquid atomizing device , comprising a medical solution cup coupled to an external air pump , and an output cover detachably installed onto the medical solution cup , and the medical solution cup having a medical solution storage tank , and the medical solution storage tank having a jet pipe protruded upwardly from the tank bottom of the medical solution storage tank , and the top of the jet pipe having a conical nozzle , and the output cover having an output flow passage formed therein and communicated to the outside , and an external atomizing socket disposed under the output flow passage and capable of sheathing the jet pipe , and a gap formed between the inner periphery of the atomizing socket and the outer periphery of the jet pipe for filling the medical solution stored in the medical solution storage tank into the gap , characterized in that the top inner periphery of the atomizing socket has a tapered portion superimposed on the top outer periphery of the conical nozzle to block the gap , and a linear opening formed at the top surface of the atomizing socket above the tapered portion for increasing the flow of the medical solution , and the linear opening includes two long sides and two short sides disposed between both ends of ...

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Номер записи: 10
03-01-2019 дата публикации

ACCESSORY DEVICE FOR METERED DOSE INHALER AND METHODS OF USE

Номер: US20190001080A1
Автор: OKADIGWE Cyril
Принадлежит:

An accessory device for use with a hand-held metered dose inhaler (MDI), comprising: a housing, sized and shaped to mount the MDI therein; a movement mechanism configured to cause compressive movement of at least one piece of the housing to activate the MDI; and, at least one side-mounted movement actuator operationally connected to the movement mechanism to instigate the movement. 1. An accessory device for use with a hand-held metered dose inhaler (MDI) , comprising:a housing, sized and shaped to mount the MDI therein;a movement mechanism configured to cause compressive movement of at least one piece of the housing to activate the MDI; and,at least one movement actuator, mounted on a side of the housing, operationally connected to the movement mechanism to instigate the movement.2. An accessory device according to claim 1 , further comprising a fastener removably attachable to the housing and at least partially enclosing the MDI to retain the MDI within the housing.3. An accessory device according to claim 2 , wherein the fastener is a fastening strap.4. An accessory device according to claim 1 , wherein the housing comprises a header and a lower body.5. An accessory device according to claim 4 , wherein the lower body is moveably disposed in at least one channel of the header claim 4 , such that initiation of the movement actuator causes the lower body to move relative to the header by sliding in the channel.6. An accessory device according to claim 5 , wherein the at least one side-mounted movement actuator is mounted on the housing at a pivot point.7. An accessory device according to claim 5 , wherein the at least one side-mounted movement actuator is provided with at least one tooth configured as a counterpart to at least one groove in the header claim 5 , such that engagement of the groove by the tooth effectuates movement of the lower body relative to the header.8. An accessory device according to claim 6 , wherein the at least one side-mounted movement ...

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Номер записи: 11
03-01-2019 дата публикации

PERSONAL VAPORIZING DEVICE

Номер: US20190001087A1
Автор: "KATZNELSON Be eri", Davidson Perry, OREN Eran, RESHEF Nimrod, Schorr Aaron, SCHWARTZ Binyamin
Принадлежит:

According to some embodiments there is provided a device configured for releasing at least one substance from source material, comprising: a housing; a plurality of source material sections positioned at fixed locations with respect to the housing; a plurality of airflow paths, each airflow path associated with at least one source material section; each airflow path associated with at least one blocking element which prevents flow of air through the path; and an actuator operably coupled to the blocking element, the actuator configured for unblocking the airflow path of at least one selected source material section to allow flow of air to and through source material within the selected section. 1. A device configured for releasing at least one substance from source material , comprising:a housing;a plurality of source material sections positioned at fixed locations with respect to said housing;a plurality of airflow paths, each airflow path associated with at least one of said source materials sections; each airflow path associated with at least one blocking element which prevents flow of air through said path; andan actuator operably coupled to said blocking element, said actuator configured for unblocking said airflow path of at least one selected source material section to allow flow of air to and through source material within said section.26-. (canceled)7. The device according to claim 1 , wherein said blocking element comprises a cover of said source material section.8. The device according to claim 7 , wherein said actuator is configured for shifting said cover to a position in which air flow is allowed to and through source material of said section.9. The device according to claim 8 , wherein said actuator is configured for shifting said cover using magnetic attraction.10. (canceled)11. The device according to claim 1 , wherein said plurality of source material sections are arranged linearly along a long axis claim 1 , and wherein said actuator is slidable ...

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Номер записи: 12
03-01-2019 дата публикации

NASAL DELIVERY ASSEMBLY FOR A FLUID PRODUCT AND METHOD FOR ACTUATING THE ASSEMBLY

Номер: US20190001088A1
Автор: PETIT Ludovic
Принадлежит: APTAR FRANCE SAS

A nasal fluid dispenser assembly () having a first reservoir () of fluid, a metering pump () mounted on the first reservoir () and including a piston (); a compressed gas flow generator system; a nasal endpiece () having a connection portion () fastened to the outlets of the pump and valve (), a fluid chamber () that receives the dose of fluid and the flow of compressed gas, and a nasal insertion element ( that extends longitudinally along an axis (B) and contains a dispenser channel () connected to the fluid chamber and has a dispenser orifice (). The axis (B) forms an angle (α) relative to the longitudinal axis (A). The dose of fluid is dispensed into the fluid chamber and then expelled under pressure by the flow of compressed gas out from the fluid chamber through the dispenser channel () the dispenser orifice (). 1. A nasal fluid dispenser assembly , characterized in that it comprises:a first reservoir containing a plurality of doses of a fluid, a metering pump being mounted on said first reservoir so as to dispense a dose of said fluid each time said dispenser assembly is actuated, said metering pump including a piston that is movable axially along a longitudinal axis (A);a compressed gas flow generator system for dispensing a flow of compressed gas each time said dispenser assembly is actuated;a nasal endpiece comprising a connection portion and a nasal insertion element, said connection portion being fastened at one end to the outlet of said metering pump, and at the other end to the outlet of said compressed gas flow generator system, said connection portion including a fluid chamber that, each time said dispenser assembly is actuated, receives the dose of fluid dispensed by said metering pump, and the flow of compressed gas dispensed by said compressed gas flow generator system, said nasal insertion element comprising an elongate body for inserting into a user's nostril, said elongate body extending longitudinally along an axis and containing a dispenser ...

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Номер записи: 13
13-01-2022 дата публикации

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

Номер: US20220008669A1
Автор: Charles Eric Hunter, Chengjie LI, Christopher W. Maurer, Jack C. Hunter, John H. Hebrank, Louis Thomas Germinario
Принадлежит: Pneuma Respiratory Inc

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

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Номер записи: 14
20-01-2022 дата публикации

ATOMIZER

Номер: US20220015456A1
Автор: LIU Xiang
Принадлежит:

An atomizer is provided. The atomizer includes a battery rod, including a rod body, a battery, and a first electrical connection part arranged on the rod body and exposed from the rod body, wherein an end of the rod body is disposed with a receiving part, and the first electrical connection part is located in the receiving part, an atomizing head, including a housing and a second electrical connection part arranged on the housing and exposed from the housing, and a mechanical switch, arranged on the rod body and exposed outside the rod body, wherein the mechanical switch is electrically connected between the battery and the first electrical connection part, and configured to turn on or turn off an electrical connection between the battery and the first electrical connection part; wherein the first electrical connection part is in contact with the second electrical connection part when the atomizing head is inserted into the receiving part, the electrical connection between the battery and the first electrical connection part is turned on when the atomizing head is inserted into the receiving part and the mechanical switch is triggered, and thereby an electrical connection between the first electrical connection part and the second electrical connection part is turned on to supply a power to the atomizing head through the battery. Using the mechanical switch to control the battery rod whether supply a power to the atomizing head or not can ensure the effectiveness of triggering power supply for a long time. 1. An atomizer , comprising:{'b': 100', '110', '120', '110', '130', '110', '110', '110', '111', '130', '111, 'a battery rod (), comprising a rod body (), a battery () contained in the rod body (), and a first electrical connection part () arranged on the rod body () and exposed from the rod body (), wherein an end of the rod body () is disposed with a receiving part (), and the first electrical connection part () is located in the receiving part ();'}{'b': 200', ' ...

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Номер записи: 15
08-01-2015 дата публикации

DELIVERY DEVICES

Номер: US20150007811A1
Автор: Andreassen Erik, Djupesland Per Gisle, Gaarder Rune Harald, Nilsson Andreas, Péricé Christophe
Принадлежит: OPTINOSE AS

A delivery device for delivering a metered amount of substance (L) in response to exhalation by a user, the delivery device comprising: a mouthpiece () through which the user in use exhales; an outlet () from which substance Is delivered; and a dispensing unit () which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member () which includes a cavity () for containing a metered amount of substance, an outlet nozzle () which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing () member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle. 1. A delivery device for delivering a metered amount of substance in response to exhalation by a user , the delivery device comprising:a mouthpiece through which the user in use exhales;an outlet from which substance is delivered; anda dispensing unit which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member which includes a cavity for containing a metered amount of substance, an outlet nozzle which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle.2. The delivery device of claim 1 , wherein the cavity is an elongate cavity.3. The delivery device of claim 2 , wherein the cavity has a cylindrical section and the dispensing member comprises a ball which is moved along the cavity by the driving pressure created by ...

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Номер записи: 16
08-01-2015 дата публикации

Assembly for an inhalation device and use of a sealing member

Номер: US20150007818A1
Автор: Stefan Mayer
Принадлежит: SANOFI SA

An assembly for an inhalation device is provided having a storage chamber configured to hold a plurality of doses of a substance, a metering element configured to be moved with respect to the storage chamber and having, a metering chamber, wherein a sub-quantity of the substance can be retrieved from the storage chamber by means of the metering chamber when the metering element is moved in a dosing direction with respect to the storage chamber The assembly also includes a sealing member mechanically cooperating with the metering element, that has an opening which receives the metering element, a main part and a sealing lip, wherein the sealing lip and the main part define a recess, wherein the recess is arranged between the sealing lip and the main part and, wherein the sealing lip is deflectable into the recess. A method using a sealing member for mechanical cooperation with a metering element of an inhalation device is also described.

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Номер записи: 17
14-01-2021 дата публикации

EPIDERMAL SUSPENSION SPRAY DEVICE

Номер: US20210008299A1
Автор: Ahuja Bharatkumar, Anasane Sandip, Mahale Chetan, Panse Nikhil, Phulwar Rohit, Poyarekar Saiprasad
Принадлежит:

A dermo-epidermal suspension spray device, said device comprising: a refill capsule (H) to contain skin pieces, said refill capsule (H) placed inside a sample loader (B); a stirrer mechanism to be connected to said refill capsule (H/) so that a solution of skin pieces and saline is continuously stirred to maintain a uniformly suspended solution or skin pieces and saline in a non-homogenous stirred manner; a nozzle (A) to spray said uniformly suspended solution from said refill capsule (H/) onto a portion of a body where grafting is required; an actuator (D) to enable spraying of said uniformly suspended solution; and air container (G) to store compressed air, said air container (G) connected to said refill capsule (H) so that said compressed air is used for spraying said uniformly suspended solution of skin pieces and saline through said nozzle (A). 1. A dermo-epidermal suspension spray device , the device comprising:a refill capsule configured to contain skin pieces, wherein the refill capsule is inside a sample loader;a stirrer configured to be connected to the refill capsule so that a solution of skin pieces and saline is continuously stirred to maintain a uniformly suspended solution of skin pieces and saline in a non-homogenous stirred manner;a nozzle, co-axial to the refill capsule and operatively in front of the refill capsule, wherein the nozzle is configured to spray the uniformly suspended solution from the refill capsule onto a portion of a body where grafting is required;an actuator configured to drive the uniformly suspended solution from the refill capsule through the nozzle on to the portion of body; andan air container configured to store compressed air, wherein the air container is connected to the refill capsule so that the compressed air is used for spraying the uniformly suspended solution of skin pieces and saline through the nozzle.2. The device as claimed in claim 1 , wherein the stirrer is a motorized shaker.3. The device as claimed in claim ...

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Номер записи: 18
14-01-2021 дата публикации

VAPOR MIXING APPARATUS

Номер: US20210008303A1
Автор: Bahl Darran
Принадлежит:

A vapor blending device is provided, generally having a base, a carrier removably couplable to the base for carrying a first and second vapor generating system. The first and second vapor generating systems including airflow generators and controllers configured to vary voltage to each of the first and second vapor generating devices and the airflow generators. A container is positioned in fluid communication with the first and second vapor generating systems and configured to retain a quantity of vapor. In some examples, one controller is configured to cause the first vapor generating system to generate a quantity of a first vapor, and another controller is configured to cause the second vapor generating system to generate a quantity of a second vapor in a predetermined ratio to the quantity of the first vapor. The vapor in the predetermined ratio is stored in the container for later removal. 1. A vapor blending device , comprising:a base;a carrier removably couplable to the base and having a first aperture and a second aperture; a first vapor generating device having a first heating element positioned within the first aperture, the first vapor generating device having a portion protruding through the carrier away from the base;', 'a first airflow generator positioned in the base and in fluid communication with the first vapor generating device; and', 'a first controller in electrical communication with the first heating element of the first vapor generating device and the first airflow generator, the first controller configured to vary voltage to one or more of the first heating element of the first vapor generating device and the first airflow generator;, 'a first vapor generating system comprising a second vapor generating device having a second heating element positioned within the second aperture, the second vapor generating device having a portion protruding through the carrier away from the base;', 'a second airflow generator positioned in the base and in ...

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Номер записи: 19
14-01-2021 дата публикации

Inhaler with aperatured porous support element

Номер: US20210008306A1
Автор: Daniele SANNA, Fabiana SPADARO, Gennaro CAMPITELLI, Gianpaolo D'AMBRA, Silvia CAPO
Принадлежит: PHILIP MORRIS PRODUCTS SA

An inhaler article includes a body extending from a mouthpiece end to a distal end with an endpiece element at the distal end. A capsule cavity is defined within the body and extends a cavity length. An air inlet region is between the endpiece element and the capsule cavity. The air inlet region has an air inlet and an air passageway extending from the air inlet to the capsule cavity. The air passageway has an inner diameter less than an inner diameter of the capsule cavity. A porous support element defines a downstream end of the capsule cavity. The porous support element includes one or more apertures extending the length of the porous support element.

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Номер записи: 20
14-01-2021 дата публикации

SPRAY DEVICE, SPRAY UNIT AND SPRAY CARTRIDGE

Номер: US20210008577A1
Автор: de Kruijf Wilhelmus Petrus Johannes, Nijdam Wietze, Van Egmond Henri Joseph, van RIJN Cornelis Johannes Maria
Принадлежит:

The invention relates to a spray device having a spray nozzle unit and at least one further spray nozzle unit. Each spray nozzle unit has at least one spray nozzle body, wherein said at least one spray nozzle body comprises a chamber for receiving a pressurized fluid. Said chamber is bounded by a spray wall having at least one spray orifice that extends through said spray wall and opens to an external environment. Each of said at least one orifice in a spray wall has a substantially identical predetermined size lying in a predetermined range and releases a mono disperse spray jet of the pressurized fluid fed from the associated reservoir. Said range within said first spray nozzle unit differs from said range within said at least one further spray nozzle unit, particularly said ranges do not overlap. 1. A Spray device , comprising a first spray unit , said first spray unit comprising a spray nozzle unit in fluid communication with a first reservoir for holding a quantity of a fluid to be sprayed , wherein said first spray nozzle unit comprises a first spray nozzle body with a first spray wall that is provided with at least one first spray orifice extending through a thickness of said first spray wall , said at least one first spray orifice receiving , during operation , said first fluid under pressure from said first reservoir at an inlet side and releasing a spray jet of said fluid to an external environment at a spray side , and wherein each of said at least one orifice has a substantially identical predetermined size , lying in a predetermined range , and comprising at least one further spray unit , said further spray unit comprising a further spray nozzle unit in fluid communication with a further reservoir for holding a quantity of a further fluid to be sprayed , wherein said further spray nozzle unit comprises a further spray nozzle body with a further spray wall that is provided with at least one further spray orifice extending through a thickness of said ...

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Номер записи: 21
10-01-2019 дата публикации

DRUG DOSE CARTRIDGE FOR AN INHALER DEVICE

Номер: US20190009039A1
Автор: Davidson Perry, LIFSHITZ Roee, Schorr Aaron, SCHWARTZ Binyamin
Принадлежит: Syqe Medical Ltd.

Devices and methods are described for preparing, managing, and/or administering metered doses of substances for vaporized administration. In some embodiments, dose cartridges comprising at least one botanical substance include a heating element integrated into the cartridge in close contact with the botanical substance. In some embodiments, cartridge-mounted doses are stored in a magazine, optionally in carousel form, before use. Transport of a cartridge from a magazine to an electrically operated vaporizing chamber which activates the heating element is provided by a mechanical pickup means. 1. A dose cartridge container comprising a plurality of dose cartridges within a closed container to be used in an inhaler device , wherein the dose cartridge container is a carousel dose cartridge container such that the carousel provides selectable access to dose cartridges positions in the carousel.2. The dose cartridge container of claim 1 , wherein the carousel provides selectable access by being revolved within a carousel enclosure.3. The dose cartridge container of claim 1 , wherein the carousel is configured to allow access to dose cartridges in the sequential order of the dose cartridges positions within the carousel.4. The dose cartridge container of claim 1 , wherein the carousel is configured to allow access to dose cartridges in an order different from the sequential order of the dose cartridges positions within the carousel.5. The dose cartridge container of claim 1 , wherein the carousel is configured to allow access to dose cartridges according to their specified location in the dose cartridge container.6. The dose cartridge container of claim 1 , wherein the number of the dose cartridges carried by the dose cartridge container is within the range of 10-200 doses.7. The dose cartridge container of claim 1 , wherein each of the plurality of dose cartridges comprises a drug substance.8. The dose cartridge container of claim 1 , wherein the plurality of dose ...

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Номер записи: 22
09-01-2020 дата публикации

Ambroxol dry powder for inhalation use with bronchial target

Номер: US20200009334A1
Автор: Huaxin WU, QI Wu
Принадлежит: Hollycon Italy Pte Ltd - Srl

The present invention relates to a preparation for inhalation use in form of dry powder comprising particles of ambroxol and/or hydrochlorides thereof, and at least a pharmaceutically acceptable excipient and/or dispersant wherein at least 85% of said particles has a geometrical diameter from 3 to 5 μm. The present invention further relates to the methods for preparing such composition and uses thereof. The present invention thanks to the very fine particles of dry powder, as above defined, constitutes a composition for inhalation use with optimum performances which, combined with inhaler action, reaches and acts directly on the bronchi or on the damaged respiratory tract. The local action and the quick absorption of the drug guarantee good features of bioavailability. The decrease in dosing Ambroxol with respect to the other existing oral or injectable formulations allows to reach quickly, locally and safely, the therapeutic target.

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Номер записи: 23
15-01-2015 дата публикации

Portable devices and methods for providing scents

Номер: US20150014429A1
Автор: Zachary David Rome
Принадлежит: Woodpecker Laboratories LLC

The present technology is directed to devices and methods for providing scents to a user—in particular, in a portable way that can dispense a plurality of scents to an individual user based on the individual user's personal preferences or needs.

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Номер записи: 24
03-02-2022 дата публикации

RESERVOIR FOR AN INHALATION DEVICE

Номер: US20220031969A1
Автор: Rawert Juergen
Принадлежит:

The invention relates to the field of inhalation devices for medically active liquids. In particular, the invention relates to a cartridge containing said liquid for such an inhalation devices. A cartridge () for the storage of a medically active liquid (L) and for supply of the same to a pumping unit of an inhalation device comprises an outer container () enclosing a collapsible inner bag (), and a cap () which is capable of closing the container (), the cap () further providing an openable access opening () to the inner bag (), wherein further, the container () of the cartridge () has a pressure compensation opening (), and wherein said pressure compensation opening () is located in a region () which is covered by the cap (). In a method for providing a pressure compensation to the collapsible inner bag-containing interior of the outer container () of a cartridge (), initially, before the cartridge () is connected to a holder (), the pressure compensation opening () is closed, and subsequently, when the cartridge () is connected to the holder (), by way of mechanically deforming (i) a pressure compensation opening comprising region of the outer container () and/or (ii) a compensation opening covering region of the cap (), an air gap () is provided which allows for a pressure equalization of the bag-containing interior with the ambient pressure. 2. Cartridge according to claim 1 , wherein claim 1 , in a state when the cartridge is disconnected from the holder claim 1 , the at least one pressure compensation opening is covered by the cap claim 1 , while in a state when the cartridge is connected to the holder claim 1 , said pressure compensation opening is open.3. Cartridge according to claim 2 , wherein claim 2 , in a state when the cartridge is disconnected from the holder claim 2 , the at least one pressure compensation opening is covered airtight by the cap.4. Cartridge according to claim 1 , wherein the cap and/or at least a cap connection region of the outer ...

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Номер записи: 25
03-02-2022 дата публикации

METHOD OF MAKING VAPOR-GENERATING ARTICLE INCLUDING RETENTION MEDIUM AND FRANGIBLE CAPSULE

Номер: US20220031971A1
Автор: THORENS Michel
Принадлежит: Altria Client Services LLC

The method includes defining a cavity within a housing of a vapor-generating article, the vapor-generating article having a first end, a second end and a middle section, first inserting at least one portion of a retention medium within the housing between the first end and the middle section, and second inserting a first frangible capsule to be near or at least partially within the retention medium, the first frangible capsule including a first volatile substrate. 1. A method , comprising:defining a cavity within a housing of a vapor-generating article, the vapor-generating article having a first end, a second end and a middle section;first inserting at least one portion of a retention medium within the housing between the first end and the middle section; andsecond inserting a first frangible capsule to be near or at least partially within the retention medium, the first frangible capsule including a first volatile substrate.2. The method of claim 1 , further comprising:first configuring the vapor-generating article to allow air to be drawn through the cavity from the first end to the second end if a negative pressure is applied to the second end.3. The method of claim 2 , further comprising:second configuring the vapor-generating article to be connected to an electrically-operated vapor-generating device.4. The method of claim 1 , further comprising:third inserting a second frangible capsule to be near or at least partially within the retention medium, the second frangible capsule including a second volatile substrate.5. The method of claim 4 , wherein the second inserting inserts the first frangible capsule such that the first volatile substrate includes a first constituent of a pre-vapor formulation and the third inserting inserts the second frangible capsule such that the second volatile substrate includes a second constituent of the pre-vapor formulation.6. The method of claim 4 , wherein the second inserting inserts the first frangible capsule such that the ...

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Номер записи: 26
03-02-2022 дата публикации

DRUG DOSE CARTRIDGE FOR AN INHALER DEVICE

Номер: US20220031972A1
Автор: Davidson Perry, LANDA Shay, LIFSHITZ Roee, Schorr Aaron, SCHWARTZ Binyamin
Принадлежит: Syqe Medical Ltd.

Devices and methods are described for preparing, managing, and/or administering metered doses of substances for vaporized administration. In some embodiments, dose cartridges comprising at least one botanical substance include a heating element integrated into the cartridge in close contact with the botanical substance. In some embodiments, cartridge-mounted doses are stored in a magazine, optionally in carousel form, before use. Transport of a cartridge from a magazine to an electrically operated vaporizing chamber which activates the heating element is provided by a mechanical pickup means. 1. A dose cartridge dispensing assembly comprising:a dose cartridge dispenser which stores a plurality of dose cartridges therein; the dose cartridge dispenser comprising a housing including at least one aperture leading into and out of an inner volume defined by said housing;at least one administration element shaped and sized to be at least partially inserted into said at least one aperture, said administration element configured to carry a dose cartridge out from said dose cartridge dispenser or back into said dose cartridge dispenser via said at least one aperture; wherein said administration element is configured to engage a first dose cartridge in a manner which geometrically blocks engagement of said administration element to another, second dose cartridge, such that removal of said second dose cartridge from said dose cartridge dispenser is enabled only when said first dose cartridge is returned by said administration element back into said dose cartridge dispenser.2. The assembly according to claim 1 , wherein said plurality of dose cartridges are arranged on a carousel inside said housing of said dose cartridge dispenser claim 1 , and wherein insertion of said administration element into said at least one aperture triggers rotation of said carousel.3. The assembly according to claim 1 , wherein said plurality of dose cartridges are transported within said housing ...

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Номер записи: 27
03-02-2022 дата публикации

NASAL DELIVERY DEVICES

Номер: US20220031980A1
Автор: Djupesland Per Gisle, Sheldrake Colin David
Принадлежит:

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece () through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece () for fitting to a nostril of a subject, the nosepiece including a nozzle () through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit () for delivering substance through the nozzle of the nosepiece. 138-. (canceled)39. A nasal delivery device for delivering a substance to a nasal airway of a subject , comprising:a housing;a mouthpiece through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject;a nosepiece for fitting to a nostril of the subject, wherein the nosepiece includes a nozzle through which the substance is in use delivered as an aerosol spray into the nasal airway of the subject;a manually-actuatable substance supply unit for delivering the substance through the nozzle, wherein the substance supply unit comprises a substance-containing chamber which contains the substance and extends from an aperture in the housing as an actuating part of the substance supply unit, and a mechanical delivery pump which is actuatable by depression of the substance-containing chamber to deliver the substance from the nozzle; anda valve assembly which is fluidly connected to the mouthpiece and the nosepiece and operable between a closed configuration substantially blocking a fluid communication path between the mouthpiece and the nosepiece and an open configuration permitting a flow of fluid through the fluid communication path between the mouthpiece and the nosepiece, wherein the substance-containing chamber is coupled to the valve assembly and configured to provide for simultaneous actuation of the mechanical delivery pump and opening of the valve assembly to deliver an air flow through the fluid communication path ...

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Номер записи: 28
09-01-2020 дата публикации

TRAINING DEVICE FOR AN INHALER, AND AN INHALER

Номер: US20200013313A1
Автор: Von Hollen Dirk Ernest
Принадлежит:

According to an aspect, there is provided a training device for use in an inhaler, the training device comprising a body that is configured to be received at a first position in a housing of an inhaler, wherein the body comprises an interface arranged to connect to a canister interface in the housing of the inhaler; an electrical circuit configured to perform one or more functions; and a circuit triggering mechanism that comprises a switch for enabling the electrical circuit to perform the one or more functions when the switch is closed, wherein the circuit triggering mechanism is configured such that the switch is closed when the body is pressed from the first position towards the canister interface and into a second position in the housing of the inhaler. 1. A training device for use in an inhaler in place of a medication canister , the training device comprising:a canister-shaped body that is configured to be received at a first position in a housing of an inhaler, wherein the body comprises an interface arranged to connect to a canister interface in the housing of the inhaler;an electrical circuit configured to perform one or more functions; anda circuit triggering mechanism that comprises a switch for enabling the electrical circuit to perform the one or more functions when the switch is closed, wherein the circuit triggering mechanism is configured such that the switch is closed when the body is pressed from the first position towards the canister interface and into a second position in the housing of the inhaler; wherein the electrical circuit and circuit triggering mechanism are contained within the body.2. A training device as claimed in claim 1 , wherein the circuit triggering mechanism comprises a resilient component configured to provide a force that resists the pressing of the body into the housing of the inhaler.3. A training device as claimed in claim 2 , wherein the resilient component is configured to return the body to the first position in the ...

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Номер записи: 29
18-01-2018 дата публикации

Dry Powder Inhaler Comprising Fluticasone Propionate and Salmeterol Xinafoat

Номер: US20180015035A1
Автор: Dalvi Mukul, TEE Seah Kee
Принадлежит: Teva Branded Pharmaceutical Products R&D, Inc.

This invention provides a dry powder inhaler comprising: a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of fluticasone propionate per actuation is less than 100 μg; and wherein the dose provides a baseline-adjusted FEVin a patient of more than 150 mL within 30 minutes of receiving the dose. A method of treating a patient includes administering to a patient a dry powder medicament having fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of fluticasone propionate per actuation is less than 100 pg; and wherein the dose provides a baseline-adjusted FEVin a patient of more than 150 mL within 30 minutes of receiving the dose. 1. A dry powder inhaler comprising:a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier;wherein, the delivered dose of fluticasone propionate per actuation is less than 100 μg; and{'sub': '1', 'wherein the dose provides a baseline-adjusted FEVin a patient of more than 150 mL within 30 minutes of receiving the dose.'}2. The inhaler as claimed in claim 1 , wherein the baseline-adjusted FEVremains above 150 mL for at least 6 hours after receiving the dose.3. The inhaler as claimed in claim 1 , wherein the dose of fluticasone propionate is less than 75 μg.4. The inhaler as claimed in claim 3 , wherein the doses of fluticasone propionate/salmeterol in μg are 50/12.75 or 25/12.75 per actuation.5. The inhaler as claimed in claim 1 , wherein the particle size of the fluticasone propionate is d10=0.4-1.1 μm claim 1 , d50=11.1-3.0 μm claim 1 , d90=2.6-7.5 μm and NLT95%<10 μm claim 1 , measured by laser diffraction as an aqueous dispersion.6. The inhaler as claimed in claim 1 , wherein the particle size of the salmeterol xinafoate is d10=0.4-1.3 μm claim 1 , d50=1.4-3.0 μm claim 1 , d90=2.4-6.5 μm and NLT95%<10 μm claim 1 , measured by laser diffraction as an aqueous dispersion.7. The ...

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Номер записи: 30
21-01-2016 дата публикации

AEROSOL GENERATOR FOR GENERATING AN INHALATION AEROSOL

Номер: US20160015912A1
Автор: de Kruijf Wilhelmus Petrus Johannes, HUIJGEN Tom Vincent, Nijdam Wietze, Wissink Jeroen Mathijn
Принадлежит:

An aerosol generator for generating an inhalation aerosol from an inhalation liquid, includes an intake duct for guiding air to a mouth of a user, and a nozzle, arranged in the intake duct for injecting the inhalation liquid into the intake duct. The nozzle is arranged for generating a Rayleigh droplet train of the inhalation liquid propagating along a droplet train propagation path. The intake duct includes at least two first orifices having at least partly opposing discharging directions extending towards the droplet train propagation path. The at least two first orifices are configured for providing respective first air streams in at least partly opposing directions so as to interact in the droplet train propagation path. 1. An aerosol generator for generating an inhalation aerosol from an inhalation liquid , comprising:an intake duct for guiding air to a mouth of a user, and 'wherein the nozzle is arranged for generating a Rayleigh droplet train of the inhalation liquid propagating along a droplet train propagation path, and', 'a nozzle, arranged for injecting the inhalation liquid into the intake duct,'} 'at least two first orifices, each of the first orifices having a discharging direction in which respective first air streams discharge from the respective first orifices, wherein the first orifices are arranged to provide the first air streams in mutually colliding discharging directions, the discharging directions of the first orifices being directed towards the droplet train propagation path, the at least two first orifices being configured for providing the respective first air streams to flow from the respective orifices along the respective discharging directions to the droplet train propagation path so as to interact with each other in the droplet train propagation path, wherein a droplet size decreases with increasing air flow.', 'wherein the intake duct comprises2. The aerosol generator according to claim 1 , wherein the first orifices are configured ...

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Номер записи: 31
21-01-2016 дата публикации

MEDICAMENT DELIVERY DEVICES

Номер: US20160015914A1
Автор: Parkes Philip Carl
Принадлежит:

A medicament delivery device () comprises a metering member () mounted for rotation adjacent a reservoir () containing a bulk quantity of medicament. The metering member () is adapted when at a filling position to volumetrically meter a desired dose of medicament from the reservoir (). By rotation of the metering member () in a first sense said dose is transferred to a dispensing position at which the dose can be dispensed from the device (). The metering member () and/or a component () to which the metering member () is operably linked is provided with formations () effective to prevent reverse rotation of the metering member () from the filling position.

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Номер записи: 32
21-01-2016 дата публикации

Element for Inhaling Medicinal Substances

Номер: US20160015915A1
Автор: Paolo Narciso
Принадлежит:

The invention relates to an inhaler element, to be inserted inside a nasal cavity for inhaling medicinal substances, characterized in that it comprises, inside, a dispensing device, said dispensing device providing a convergent conduct for inlet of respiration flow and a divergent conduct for exit of respiration flow, and storage means for the substance to be inhaled, said storage means being provided in flow communication substantially in correspondence of the transition zone between said convergent conduct and said divergent conduct of said dispensing device.

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Номер записи: 33
17-01-2019 дата публикации

Low dose therapeutic treatment

Номер: US20190015382A1
Автор: Aaron SCHORR, Binyamin Schwartz, Daniella Atzmony, Perry Davidson, Seth Kindler, Shlomo ALMOG
Принадлежит: Syqe Medical Ltd

Some embodiments of the invention relate to a system for delivering to a subject at least one pre-determined amount of THC, the system comprising: a memory which stores a scheduled regimen for delivery of THC to the subject, the scheduled regimen defining: a maximal amount of THC to be delivered, the amount being 0.75 mg THC or less, and a time period within which that amount is delivered, the time period being 2 hours or longer; a decision module which decides, according to the scheduled regimen, if a delivery should take place; and an inhaler device for delivering THC to the subject, the inhaler device comprising a controller which carries out delivery of THC based on the decision made by the decision module.

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Номер записи: 34
17-01-2019 дата публикации

Dual Chamber Nebulizer Apparatus

Номер: US20190015607A1
Автор: Glen McCants
Принадлежит: Individual

A dual chamber nebulizer apparatus for atomizing and administering a first and second liquid medicine includes a housing having first and second chambers for holding the first and second liquid medicines. An atomizer member is situated in the housing and configured to atomize liquid into vapor. An air flow member is coupled to the housing and in fluid communication with the atomizer, the flow member having an inlet port for receiving a compressed air flow to the atomizer member. First and second aspiration tubes are in communication with the atomizer member and extend into first and second chambers, respectively. The atomizer member includes a junction in communication with the first and second aspiration tubes, the valve selectively allowing both of the liquid medicines to be drawn through respective aspiration tubes and directed to the atomizer member when the compressed airflow is directed to the atomizer member.

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Номер записи: 35
17-01-2019 дата публикации

A MOBILE INHALER AND A CONTAINER FOR USING THEREWITH

Номер: US20190015612A1
Автор: Guidetti Francesco, Lacour-Gayet Julien, Lacour-Gayet Philippe, Marmur Abraham, Nedivi Dror, Shpiro Zeev
Принадлежит:

A mobile inhaler is provided and a container for using therewith. The mobile inhaler comprises: a mouthpiece comprising at least one inhaling opening; a body element connected to the mouthpiece and comprising a housing for holding a DC power source; a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; a nebulizer comprising an ultrasonic vibrator and a mesh, wherein the ultrasonic vibrator is activated by the AC voltage, and wherein the nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from the mouthpiece; and an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from the enclosure to the nebulizer. 1. A mobile inhaler , comprising:a mouthpiece comprising at least one inhaling opening;a body element connected to the mouthpiece and comprising a housing for holding a DC power source;a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; 'an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from said enclosure to the nebulizer.', 'a nebulizer comprising an ultrasonic vibrator and a mesh, wherein said ultrasonic vibrator is activated by said AC voltage, and wherein said nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from said mouthpiece; and'}2. The mobile inhaler of claim 1 , wherein the enclosure includes a mechanism to enable fluid transfer from said enclosure to the nebulizer claim 1 , irrespective of a spatial angle at which it is being hand-held.3. The mobile inhaler of claim 1 , wherein said liquid is in a contact with a wick.4. ...

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Номер записи: 36
17-01-2019 дата публикации

Delivery of Gases to the Nasal Airway

Номер: US20190015621A1
Автор: Per Gisle Djupesland, Roderick Peter Hafner
Принадлежит: OPTINOSE AS

A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.

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Номер записи: 37
16-01-2020 дата публикации

PORTABLE DEVICE FOR INHALATION OF AT LEAST ONE ACTIVE COMPOSITION

Номер: US20200016344A1
Автор: ABULFEDA Julien, DE LACROIX DE RAVIGNAN AYMARD, DELAHAYE VALENTIN, Fischer Alexis, HARANG MARIE, MATTE JEAN-BAPTISE, MONTANARI DAMIEN, SCHECK ALEXANDRE
Принадлежит:

The portable device () for inhalation of at least one active composition comprises: 129-. (canceled)30. Portable device for inhalation of at least one active composition , comprising:at least one reservoir for storing an active composition;at least one intermediate chamber connected to at least one reservoir;an inhalation line connected to the intermediate chamber;a means for aerosolizing the active composition coming from a reservoir; anda regulator) for regulating the quantity of aerosolized active composition according to a command representing a quantity of active composition to be aerosolized received by the regulator.31. Device according to claim 30 , wherein at least one aerosolization means is a nebulizer for liquid active composition stored in a reservoir.32. Device according to claim 31 , wherein a nebulizer comprises a screen having openings claim 31 , and a means for making the screen oscillate claim 31 , the regulator comprising a means for closing at least one portion of the openings according to the quantity of active composition to be aerosolized.33. Device according to claim 31 , wherein the nebulizer comprises a means for making a surface oscillate claim 31 , the regulator being configured to make the surface oscillate at a frequency determined as a function of the quantity of active composition to be aerosolized and/or of characteristics of the active composition to be nebulized.34. Device according to claim 33 , wherein the surface is a screen having openings claim 33 , the regulator being configured to make the screen oscillate at a frequency determined as a function of the quantity and/or characteristics of the active composition to be nebulized or wherein the surface is located in the bottom portion of the reservoir so as to transmit vibrations to the active composition claim 33 , the regulator being configured to command the oscillation at a frequency determined as a function of the quantity and/or characteristics of the active composition to ...

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Номер записи: 38
21-01-2021 дата публикации

Dry Powder Inhaler

Номер: US20210016024A1
Автор: Esteve Victor
Принадлежит: Emphasys Importadora Exportadora e Distribuidora Ltda.

A dry powder inhaler for at least two capsules containing dry powder is provided, the dry powder inhaler including: At least two capsule chambers each capsule chamber for receiving one of the capsules; a mouth piece with a mouth portion comprising a distal opening; and a duct structure between the distal opening of the mouth piece and the at least two capsule chambers, wherein the duct structure comprises at least two primary ducts, wherein the distal opening of the mouth piece leads into the at least two primary ducts, and wherein each one of the at least two primary ducts leads into the corresponding one of the at least two capsule chambers. 1. A dry powder inhaler for at least two capsules containing dry powder , the dry powder inhaler comprising:at least two capsule chambers each capsule chamber for receiving one of the capsules;a mouth piece with a mouth portion comprising a distal opening and a main body, which comprises a duct structure; andthe duct structure of the mouth piece arranged between the distal opening of the mouth piece and the at least two capsule chambers, wherein the duct structure comprises at least two primary ducts, wherein the distal opening of the mouth piece leads into the at least two primary ducts, and wherein each one of the at least two primary ducts leads into the corresponding one of the at least two capsule chambers.2. The dry powder inhaler according to claim 1 , wherein the duct structure is Y-shaped claim 1 , and wherein the duct structure comprises a secondary duct between the distal opening of the mouth piece and the at least two primary ducts.3. The dry powder inhaler according to claim 2 , wherein the secondary duct comprises a secondary cross-sectional area claim 2 , which equals or is less than a sum of primary cross-sectional areas of the at least two primary ducts.4. The dry powder inhaler according to claim 2 , wherein the length of the secondary duct is equal or greater than the length of one of the primary ducts.5. ...

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Номер записи: 39
22-01-2015 дата публикации

DRY POWDER INHALER FOR DELIVERING MULTIPE AGGLOMERATE FORMULATIONS

Номер: US20150020806A1
Автор: Berenshteyn Annaniy, BROWN SCOTT C., GALLUPPI MICHAEL A., Zuyev Aleksandr
Принадлежит:

Various embodiments provide drug products and dry powder inhalers. With various embodiments of the present invention, a de-agglomeration chamber and by-pass channel are provided which allow for various de-agglomerating capabilities for dry powder dispensers. 1. A dry powder inhaler for dispensing inhaled doses of dry powder , the dry powder inhaler comprising:a de-agglomeration chamber having at least one exit opening, a first inlet opening and a second inlet opening, said at least one exit opening, said first inlet opening and said second inlet opening being arranged such that, upon inhalation of a dose, negative pressure is applied to said at least one exit opening which causes a first stream of dry powder to be entrained from said first inlet opening into said de-agglomeration chamber directed toward said at least one exit opening, said negative pressure also causing a second stream of dry powder to be entrained from said second inlet opening into said de-agglomeration chamber directed toward said at least one exit opening, said first and second streams of dry powder colliding in said de-agglomeration chamber to form a collective stream passing through said exit opening; and,at least one by-pass channel disposed adjacent to, and separated from, said de-agglomeration chamber, said at least one by-pass channel having an inlet and an outlet, wherein, upon inhalation of a dose, negative pressure is applied to said outlet which causes a third stream of dry powder to be entrained from said inlet directed toward said outlet, said third stream of dry powder not passing through any portion of said de-agglomeration chamber.2. A dry powder inhaler as in further comprising a swirl nozzle having an opening in communication with said outlet of said by-pass channel.3. A dry powder inhaler as in claim 2 , wherein said at least one exit opening of said de-agglomeration chamber is in communication with said opening of said swirl nozzle.4. A dry powder inhaler as in further ...

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Номер записи: 40
28-01-2016 дата публикации

AEROSOL-GENERATING DEVICE COMPRISING MULTIPLE SOLID-LIQUID PHASE-CHANGE MATERIALS

Номер: US20160021932A1
Автор: Cane Michael Roger, FARINE Marie, ROWE Christopher James, SILVESTRINI Patrick Charles
Принадлежит: PHILIP MORRIS PRODUCTS S.A.

An aerosol-generating device is provided, for use in an aerosol-generating system and an aerosol-generating system including an aerosol-generating device and an aerosol-generating article. The aerosol-generating device includes a cavity configured to receive an aerosol-generating article; a first solid-liquid phase-change material positioned about a perimeter of the cavity; and heating means configured to heat the first solid-liquid phase-change material to a temperature above the melting point of the first solid-liquid phase-change material. The aerosol-generating device further includes a second solid-liquid phase-change material, wherein the melting point of the second solid-liquid phase-change material is higher than the melting point of the first solid-liquid phase-change material. 1. An aerosol-generating device for use in an aerosol-generating system , the aerosol-generating device comprising:a cavity configured to receive an aerosol-generating article;a first solid-liquid phase-change material positioned about a perimeter of the cavity;heating means configured to heat the first solid-liquid phase-change material to a temperature above the melting point of the first solid-liquid phase-change material; anda second solid-liquid phase-change material,wherein the melting point of the second solid-liquid phase-change material is higher than the melting point of the first solid-liquid phase-change material.2. The aerosol-generating device according to claim 1 , wherein the first solid-liquid phase-change material has a melting point of between 30 degrees Celsius and 70 degrees Celsius.3. The aerosol-generating device according to claim 1 , wherein the first solid-liquid phase-change material is sodium acetate trihydrate.4. The aerosol-generating device according to claim 1 , wherein the melting point of the second solid-liquid phase-change material is between 15 degrees Celsius and 25 degrees Celsius higher than the melting point of the first solid-liquid phase- ...

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Номер записи: 41
28-01-2016 дата публикации

AEROSOL-GENERATING SYSTEM WITH DIFFERENTIAL HEATING

Номер: US20160022930A1
Автор: Greim Olivier, JOCHNOWITZ Evan, Plojoux Julien, ZINOVIK Ihar
Принадлежит: PHILIP MORRIS PRODUCTS S.A.

An aerosol-generating system is provided, including an aerosol-generating article and an aerosol-generating device. The aerosol-generating article includes a first compartment having a first one of a volatile delivery enhancing compound source and a medicament source; and a second compartment having a second one of the volatile delivery enhancing compound source and the medicament source. The aerosol-generating device includes a cavity configured to receive the first compartment and the second compartment; and an external heater positioned about a perimeter of the cavity. The aerosol-generating device is configured to heat the first compartment and the second compartment so that the first compartment has a lower temperature than the second compartment. 1. An aerosol-generating system , comprising: a first compartment comprising a first one of a volatile delivery enhancing compound source and a medicament source; and', 'a second compartment comprising a second one of the volatile delivery enhancing compound source and the medicament source; and, 'an aerosol-generating article, comprising a cavity configured to receive the first compartment and the second compartment of the aerosol-generating article; and', 'an external heater positioned about a perimeter of the cavity,, 'an aerosol-generating device, comprisingwherein the aerosol-generating device is configured to heat the first compartment and the second compartment of the aerosol-generating article so that first compartment of the aerosol-generating article has a lower temperature than the second compartment of the aerosol-generating article.2. The aerosol-generating system according to claim 1 , wherein the aerosol-generating device is configured to heat the first compartment of the aerosol-generating article to a temperature between 40 degrees Celsius and 45 degrees Celsius.3. The aerosol-generating system according to claim 1 , wherein the aerosol-generating device is configured to heat the second compartment of ...

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Номер записи: 42
28-01-2016 дата публикации

Method to Deliver Medication

Номер: US20160022932A1
Автор: Derek G. Kane, Larry B. Gray, Russell H. Beavis
Принадлежит: Deka Products LP

A method to deliver medication. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and variable-volume chamber with an acoustic source and measures the acoustic response with microphones acoustically coupled to the reference and the variable-volume chamber. A disposable drug cassette is coupled to the acoustic volume sensor and includes a drug reservoir and valve. The method includes receiving a volume signal and inputs from a user input or a second sensor and controlling the valve based on these inputs.

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Номер записи: 43
25-01-2018 дата публикации

Unit for the micronization and dosage of solid active agents

Номер: US20180021527A1
Автор: Tamas KOKAI
Принадлежит: Individual

The invention relates to a unit for the micronization of a solid active agent, such as a salt, preferably table salt (NaCI), for inhalation, comprising a micronizer driven by a motor. The unit according to the invention is characterised in that micronization is performed by a unit constituted by a closed rotary drum ( 2 ) receiving a solid active agent having the same grain size, preferably 0.1-4 mm, as table salt (NaCI), where the wall surfaces of the micronizer unit are made at least in part of a material having a filtering capacity of 0.1-1000 μm, the material preferably being a mesh-like or microperforated material. A further unit according to the invention is characterised in that the micronizer consists of a rotary block ( 23 ) made of the active agent, a friction block ( 24 ) adapted to be in frictioning relation with the rotary block, and a clamping mechanism ( 25 ) adapted for holding the friction block ( 24 ) in position and for clamping the friction block ( 24 ) to the rotary block ( 23 ), the micronizer being disposed in a closed housing ( 11 ), and the wall surfaces of the housing ( 11 ) being at least in part made of a material having a filtering capacity of 0.1-1000 μm.

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Номер записи: 44
25-01-2018 дата публикации

NEBULIZATION GENERATING APPARATUS

Номер: US20180021528A1
Автор: CHEN Po-Chuan, CHEN Yi-Tong, HSIEH SHU-PIN, Lu Chih-Wei, TSAI Ting-Kai
Принадлежит:

An aerosol generating apparatus is disclosed. The apparatus includes a liquid container, an adaptor detachably engaged with the liquid container, and a driving element accommodated by the adaptor. A perforated membrane, through which a liquid can pass through, is disposed at an exit of the liquid container. Moreover, the perforated membrane faces the driving element. The driving element includes a substrate coupled with a piezoelectric element. The substrate includes an aperture that corresponds to the perforated membrane when the liquid container and the adaptor are engaged so as to receive liquid. Moreover, when the liquid container and the adaptor are engaged, the perforated membrane is in contact with the substrate at the proximity of the aperture, which is about the substrate's center. The adaptor is configured to contact the substrate's periphery only. The resulting apparatus generates aerosol at a desired efficiency with less energy needed. 1. An aerosol generating apparatus comprising:a liquid container including a perforated membrane through which a liquid can pass through;an adaptor configured to be detachably engaged with the liquid container; anda driving element including a piezoelectric element coupled to a substrate, wherein the driving element is accommodated by the adaptor, and the substrate includes an aperture that corresponds to the perforated membrane when the liquid container and the adaptor are engaged,wherein the aperture is proximate to the substrate's center, and the adaptor is configured to contact the substrate's periphery.2. The aerosol generating apparatus according to claim 1 , wherein the adaptor includes at least one jack for contacting the substrate.3. The aerosol generating apparatus according to claim 2 , wherein the substrate's periphery is adhered to the at least one jack.4. The aerosol generating apparatus according to claim 2 , wherein the at least one jack further comprise a first surface claim 2 , and the first surface ...

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Номер записи: 45
25-01-2018 дата публикации

DRY POWDER INHALER

Номер: US20180021529A1
Автор: Cocker Robin Craig, Davidson Christopher lain, Han Steve, King Ben Alexander, Mutti Paul, Stenzler Alex, Tibbatts James
Принадлежит:

The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir. 1. A dry powder cartridge device , comprising:an elongate body having an anterior end and a posterior end;a delivery lumen positioned at the anterior end of the body;a powder reservoir positioned at the posterior end of the body;a powder metering drum assembly positioned anterior to the powder reservoir; andan actuating cap positioned at the anterior end of the body mechanically engaged to the powder metering drum;wherein an amount of powder within the powder reservoir is advanced towards the powder metering drum by a piston.2. The device of claim 1 , wherein the elongate body comprises at least one air inlet fluidly connected to the powder metering drum assembly.3. The device of claim 1 , wherein the delivery lumen comprises a side air inlet to introduce a vortex airflow into the delivery lumen.4. The device of claim 1 , wherein the delivery lumen comprises a mesh to break apart powder agglomerates and vortex airflow.5. The device of claim 4 , wherein a flow of air introduced through the delivery lumen at a rate of 20 to 40 L/min is sufficient to break apart powder agglomerates and vortex airflow.6. The device of claim 1 , wherein the powder metering drum assembly comprises a cylindrical outer drum and a cylindrical inner drum insert having a curved exterior claim 1 , wherein the cylindrical outer drum lies flush against and is rotatable along the curved exterior of the inner drum insert claim 1 , and ...

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Номер записи: 46
10-02-2022 дата публикации

A MULTI-USERS MEDICAL CANNABIS DISPENSER

Номер: US20220040421A1
Автор: ARIEL Meir, Eyal Aharon, Raz Carmi, Raz Noa, ROGEL ITAI, SHADURIN YURI
Принадлежит:

Provided is a multi-users cannabis dispenser comprising: a vessel comprising at least two compartments, each compartment configured to contain at least one cannabis composition comprising at least one active component; at least one dispensing unit associated with said at least one compartment, said dispensing unit configured to controllably release from said compartments a metered dose of said composition contained therein; a control unit comprising a data input unit configured to receive data relating to a specific user, data indicating a metered dose of one or more said cannabis compositions to be administered to said specific user and/or to receive data relating to a specific cannabis composition, data indicating a metered dose of said specific composition to be administered to said specific user and configured to control the dispensing unit to release at least one said metered dose. Further provided are methods of use of the multi-users cannabis dispenser. 1. A multi-users cannabis dispenser comprising:(i) a vessel comprising at least two compartments, each compartment being configured to contain therein at least one cannabis composition comprising at least one active component;(ii) at least one dispensing unit associated with said at least one compartment, wherein said dispensing unit is configured to controllably release from said compartments a metered dose of said composition contained therein;(iii) a control unit comprising a data input unit configured to receive data relating to a specific user, data indicating a metered dose of one or more said cannabis compositions to be administered to said specific user and/or configured to receive data relating to a specific cannabis composition, data indicating a metered dose of said specific composition to be administered to said specific user and configured to control the dispensing unit to release at least one said metered dose.2. The multi-users cannabis dispenser of claim 1 , wherein said dispensing unit is ...

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Номер записи: 47
10-02-2022 дата публикации

MOBILE INHALER AND A CONTAINER FOR USING THEREWITH

Номер: US20220040423A1
Автор: Guidetti Francesco, Lacour-Gayet Julien, Lacour-Gayet Philippe, Marmur Abraham, Nedivi Dror, Shpiro Zeev
Принадлежит:

A mobile inhaler is provided and a container for using therewith. The mobile inhaler comprises: a mouthpiece comprising at least one inhaling opening; a body element connected to the mouthpiece and comprising a housing for holding a DC power source; a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; a nebulizer comprising an ultrasonic vibrator and a mesh, wherein the ultrasonic vibrator is activated by the AC voltage, and wherein the nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from the mouthpiece; and an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from the enclosure to the nebulizer. 1. A mobile inhaler , comprising:a mouthpiece comprising at least one inhaling opening;a body element connected to the mouthpiece and comprising a housing for holding a DC power source;a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage;a nebulizer comprising an ultrasonic vibrator and a mesh, wherein said ultrasonic vibrator is activated by said AC voltage, and wherein said nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from said mouthpiece; andan enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from said enclosure to the nebulizer.2. The mobile inhaler of claim 1 , wherein the enclosure includes a mechanism to enable fluid transfer from said enclosure to the nebulizer claim 1 , irrespective of a spatial angle at which it is being hand-held.3. The mobile inhaler of claim 1 , wherein said liquid is in a contact with a wick and wherein ...

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Номер записи: 48
23-01-2020 дата публикации

SYSTEM FOR ANALYZING AND CONTROLLING CONSUMABLE MEDIA DOSING INFORMATION

Номер: US20200022416A1
Автор: Alarcon Ramon
Принадлежит:

A vaporizing article, comprises a vaporizer drive circuit; one or more memories configured to store a percentage of at least one constituent in an inhalation media, one or more compensation values for at least one compensation category for the at least one constituent, and instructions; and a control circuit comprising a processor coupled with the one or more memories configured to run the instructions, the instructions configured to cause the processor to: receive a dose target for a constituent; determine whether to perform compensation for an inhalation media dose in order to ensure the dose target is met; when compensation is to be performed, determine the properly compensated inhalation media dose based on an associated compensation value for the constituent; and control the vaporizer drive circuit so as to dispense a compensated dose of the inhalation media. 1. A vaporizing article , comprising:a vaporizer drive circuit;one or more memories configured to store a percentage of at least one constituent in an inhalation media, one or more compensation values for at least one compensation category for the at least one constituent, and instructions; anda control circuit comprising a processor coupled with the one or more memories configured to run the instructions, the instructions configured to cause the processor to:receive a dose target for a constituent;determine whether to perform compensation for an inhalation media dose in order to ensure the dose target is met;when compensation is to be performed, determine the properly compensated inhalation media dose based on an associated compensation value for the constituent; andcontrol the vaporizer drive circuit so as to dispense a compensated dose of the inhalation media.2. The vaporizing article of claim 1 , wherein the one or more compensation values are compensation factors claim 1 , and wherein compensation is performed by applying the appropriate compensation factor of the compensation factors to the ...

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Номер записи: 49
23-01-2020 дата публикации

ATOMISER, IN PARTICULAR INHALER, FOR ATOMISING A LIQUID ACTIVE AGENT TO FORM AN AEROSOL AND A CORRESPONDING METHOD

Номер: US20200023145A1
Автор: Bartels Frank, Rawert Jürgen
Принадлежит:

The invention relates to an atomiser, in particular an inhaler, for atomising a liquid active agent to form an aerosol, having an active agent reservoir (), an atomiser nozzle () and a pump arrangement (), wherein a suction side () of the pump arrangement () leads into the active agent reservoir () and a pressure side () of the pump arrangement () leads into the atomiser nozzle (), and wherein the pump arrangement () has a plunger () that can be adjusted in a cylinder () in the axial direction (x) of the cylinder (), characterised in that the plunger () is supported in portions along its outer circumference () in a form-fitting manner on an inner wall () of the cylinder () and a gap () is formed in portions between the inner wall () of the cylinder () and the plunger (), wherein the plunger () is rotatably mounted around its longitudinal axis (x) in the cylinder () and can be adjusted between a suction position, in which a pump chamber () of the pump arrangement () is connected to the suction side () via the gap (), and a pump position, in which the plunger () closes the suction side (). A corresponding method is also described. 1. An atomiser , in particular an inhaler , for atomising a liquid active agent to form an aerosol , having an active agent reservoir , an atomising nozzle and a pump arrangement , wherein a suction side of the pump arrangement opens out into the active agent reservoir and a pressure side of the pump arrangement into the atomising nozzle , and wherein the pump arrangement has a piston that can be adjusted in a cylinder in an axial direction of the cylinder , wherein the piston abuts proportionately on an inner wall of the cylinder in a positive fitting manner along its outer periphery , and a gap is formed proportionately between the inner wall of the cylinder and the piston , wherein the piston is rotatably mounted around its longitudinal axis in the cylinder and can be adjusted between a suction position , in which a pump chamber of the ...

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Номер записи: 50
23-01-2020 дата публикации

NASAL DELIVERY DEVICES

Номер: US20200023146A1
Автор: Djupesland Per Gisle, Hafner Roderick Peter, Sheldrake Colin David
Принадлежит:

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber. 1a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet;a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber;a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; anda moisture-reducing element for reducing condensation at or downstream of the container chamber.. A nasal delivery device for delivering substance to a ...

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Номер записи: 51
23-01-2020 дата публикации

DELIVERY DEVICE AND ASSOCIATED METHODS OF USE

Номер: US20200023147A1
Автор: Fraser John, Gregory Shaun, Lipman Johann, O?Flaherty Brendan
Принадлежит:

A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container. 1. A delivery device for use in administering a dry powder to a biological subject's airway , the device comprising:a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; andb) one or more cantilever structures located within the housing,wherein vibration of the one or more cantilever structures facilitates entry of a dose of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway.2. The delivery device of claim 1 , wherein the gas flow through the housing forces the one or more cantilever structures to vibrate.3. The delivery device of claim 1 , wherein the one or more cantilever structures are reeds.46-. (canceled)7. The delivery device of claim 1 , wherein the device further comprises a deagglomerating surface claim 1 , wherein the cantilever structure vibrates against claim 1 , or in close proximity to claim 1 , the deagglomerating surface.8. (canceled)9. The delivery device of claim 1 , wherein ...

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Номер записи: 52
23-01-2020 дата публикации

OPTICAL DRY POWDER INHALER DOSE SENSOR

Номер: US20200023148A1
Автор: Chan Philip, WEITZEL Douglas
Принадлежит: MICRODOSE THERAPEUTX, INC.

A dry powder inhaler including a first chamber having an orifice for holding a dry powder and a gas, and a second chamber connected to the first chamber by at least one passageway for receiving an aerosolized form of the dry powder from the first chamber and delivering the aerosolized dry powder to a user. At least one optical sensor monitors aerosolized powder particles passing in the second chamber. A vibrator coupled to the first chamber aerosolizes the dry powder and causes the aerosolized powder to move through the at least one passageway thereby delivering the powder from the first chamber to the second chamber as an aerosolized dry powder. A vibrator control unit controls operation of the vibrator based on the amount of aerosolized powder particles passing in the second chamber and delivered to a user. 1. A dry powder inhaler comprising:a first chamber configured to hold a dry powder and a gas;a second chamber connected to the first chamber by at least one passageway configured to receive an aerosolized form of the dry powder from the first chamber and configured to deliver the aerosolized dry powder to a user;at least one optical sensor configured to monitor particles of dry powder passing the optical sensor in the second chamber;a vibrator coupled to the first chamber configured to aerosolize the dry powder and cause the aerosolized powder to move through the at least one passageway thereby delivering the dry powder from the first chamber to the second chamber as an aerosolized dry powder; anda vibrator control unit configured to control operation of the vibrator based on an amount of particles in the second chamber passing the at least one optical sensor.2. The inhaler of claim 1 , wherein the vibrator control unit is further configured to:estimate an amount of dry powder delivered based on the amount of particles in the second chamber passing the at least one optical sensor.3. The inhaler of claim 2 , wherein the vibrator control unit is further ...

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Номер записи: 53
28-01-2021 дата публикации

METHOD AND INHALER FOR PROVIDING TWO OR MORE SUBSTANCES BY INHALATION

Номер: US20210023316A1
Автор: Atzmony Daniella, KROLL Asaf, LUPO Tal, RESHEF Nimrod, Schorr Aaron, SCHWARTZ Binyamin
Принадлежит: Syqe Medical Ltd.

Some embodiments relate to a method for providing, during a single inhalation from an inhaler, a controllable ratio between at least a first active substance and a second active substance provided from the same source material, comprising: defining a ratio between the first and second active substances to be delivered to a user; setting operation parameters in accordance with the ratio, the operation parameters including at least one of a heating profile of the source material and an airflow profile through the source material; and operating the inhaler according to the operation parameters to deliver to the user, during a single inhalation, at least the first and second active substances at the defined ratio. 1. A method for providing , during a single inhalation from an inhaler , a controllable ratio between at least a first active substance and a second active substance provided from the same distinct source material portion , comprising:defining a ratio between the first and second active substances to be delivered to a user;setting operation parameters in accordance with the ratio, the operation parameters including at least one of a heating profile of the source material portion and an airflow profile through the source material portion; andoperating the inhaler according to the operation parameters to deliver to the user the at least first and second substances together during a single inhalation, the at least first and second active substances released from the same distinct source material portion at the defined ratio.2. The method according to claim 1 , wherein the defining includes defining an amount of at least the first substance to be delivered to the user during the single inhalation.3. The method according to claim 1 , wherein the defining includes defining a ratio between the first and second active substances.4. The method according to claim 1 , wherein a change in operation parameters changes an efficiency of at least one of: vaporization of at ...

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Номер записи: 54
17-02-2022 дата публикации

Inhalable Formulation of Fluticasone Propionate and Albuterol Sulfate

Номер: US20220047610A1
Автор: Brian Paul O&#39;NEILL, Chris David EDLIN, Hardik Kirtikumar Shah, Julian Alexander Blair, Shane Michael MCKEON
Принадлежит: Norton Waterford Ltd

This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an α-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.

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Номер записи: 55
31-01-2019 дата публикации

MEDICAL INJECTOR WITH COMPLIANCE TRACKING AND MONITORING

Номер: US20190030247A1
Автор: EDWARDS Eric S., EDWARDS Evan T., IV T. Spencer, LICATA Mark J., MEYERS Paul F., WEINZIERL David A., WILLIAMSON
Принадлежит: kaleo, Inc.

A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal. 1. A method , comprising:manipulating an electronics housing coupled to a medicament delivery device such that a first portion of the electronics housing initiates delivery of a medicament from a medicament container that is at least partially disposed within a container housing of the medicament delivery device via a delivery member and a second portion of the electronics housing changes the state of a switch; andoutputting, from an electronic circuit system, an electronic signal in response to the change of state of the switch, the electronic signal being a short-range radio frequency signal.2. The method of claim 1 , wherein the switch includes an electrical conductor and the change of state of the switch includes disrupting the electrical conductor.3. The method of claim 1 , wherein the switch includes a sensor and the change of state of the sensor includes changing the state of the sensor.4. The method of claim 1 , wherein the medicament delivery device is any one of an autoinjector claim 1 , a pen injector claim 1 , a transdermal delivery system claim 1 , an on-body delivery system claim 1 , or an inhaler.5. The method of claim 1 , wherein:the electronic signal is a first electronic signal, the ...

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Номер записи: 56
31-01-2019 дата публикации

METHOD FOR MEASURING FLOW FEATURES IN AN INHALER, INHALER AND SYSTEM

Номер: US20190030262A1
Автор: Pavkov Richard, Ziegler Dominik
Принадлежит:

The present invention relates to a method for measuring at least one inhalation flow feature in an inhaler, wherein a capsule containing a formulation is located in the inhaler, the method comprising the steps of sensing an impact feature relating to impacts of the capsule on the inhaler and correlating the impact feature to at least one inhalation flow feature. The present invention also relates to an inhaler adapted to aerosolize a formulation contained in a capsule, wherein the inhaler comprises a sensor for sensing an impact feature relating to impacts of the capsule on the inhaler and a processor for correlating the impact feature to at least one inhalation flow feature. The present invention also relates to a system comprising an inhaler adapted to aerosolize a formulation contained in a capsule and a computing device external of the inhaler, wherein the inhaler comprises a sensor for sensing an impact feature relating to impacts of the capsule on the inhaler and a data-receiving-transmitting means to receive and transmit data from and to the external computing device, wherein the external computing device also comprises data-receiving-transmitting means to receive and transmit data from and to the inhaler, wherein the inhaler and/or the external computing device comprises processing means for correlating the impact feature to at least one inhalation flow feature. 1. A method for measuring at least one inhalation flow feature in an inhaler , wherein a capsule containing a formulation is located in the inhaler , the method comprising the steps ofsensing an impact feature relating to impacts of the capsule on the inhaler andcorrelating the impact feature to at least one inhalation flow feature.2. The method according to claim 1 , wherein the impact feature is a sound generated by the impacts of the capsule on the inhaler.3. The method according to claim 1 , wherein correlating the impact feature to at least one inhalation flow feature comprisesdetermining at ...

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Номер записи: 57
04-02-2021 дата публикации

AEROSOL GENERATOR INCLUDING MULTI-COMPONENT WICK

Номер: US20210030912A1
Автор: WRENN Susan E., YANG Zuyin
Принадлежит: Philip Morris USA Inc.

An aerosol generator includes a composite conduit to transport multiple liquids to a heating element at flow rates such that the liquids arrive at the heating element in desirable concentrations. The heating element volatilizes the liquids to form volatilized fluid, which mixes with ambient air to form an aerosol with desirable concentrations of the multiple liquids. 122-. (canceled)23. A device for generation of an aerosol comprising:a reservoir containing a first liquid material and a second liquid material, the first liquid material having a first density, the second liquid material having a second density, and the first density being different from the second density such that the first liquid material and the second liquid material are in discrete, immiscible layers in the reservoir;a first wick in fluid communication with the reservoir;a second wick in fluid communication with the reservoir; andat least one capillary tube surrounded by the second wick, the second wick surrounded by the first wick, the at least one capillary tube, the first wick, and the second wick having different lengths.24. The device of claim 23 , further comprising:a heating element configured to heat the liquid material in the first wick and the second wick to form an aerosol.25. The device of claim 24 , wherein the heating element is formed of stainless steel.26. The device of claim 25 , wherein the heating element is embedded in the first wick or the second wick.27. The device of claim 24 , further comprising:a power supply electrically connectable to the heating element.28. The device of claim 27 , wherein the power supply includes a battery.29. The device of claim 27 , further comprising:a control circuit configured to regulate a supply of power from the power supply to the heating element.30. The device of claim 23 , further comprising:a mouthpiece through which the aerosol passes.31. The device of claim 23 , wherein the first liquid material comprises an aerosol former and the ...

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Номер записи: 58
01-02-2018 дата публикации

DEVICES, SYSTEMS AND METHODS FOR LOCATING AND INTERACTING WITH MEDICAMENT DELIVERY SYSTEMS

Номер: US20180033286A1
Автор: EDWARDS Eric S., EDWARDS Evan T., LICATA Mark J., MEYERS Paul F.
Принадлежит: kaleo, Inc.

In some embodiments, a method includes establishing a communications link between a computing device and an adapter. The adapter is configured to receive at least a portion of a medicament delivery device. A wireless signal is received to maintain the communications link. A relative position between the computing device and the adapter is determined. An alarm is produced when the wireless signal is not received within a time period. The alarm is based on the relative position between the computing device and the adapter. 1. A method , comprising:establishing a communications link, via a short-range wireless protocol, between a computing device and a medicament delivery device, the medicament delivery device including an electronic circuit system, the electronic circuit system including a radio;receiving a first wireless signal from the radio to maintain the communications link, the first wireless signal being periodic;producing a first alarm when the first wireless signal is not received within a time period, the first alarm indicating that the computing device is out of a communication range of the medicament delivery device;receiving a user input in response to a location prompt; andtransmitting to the radio a second wireless signal, the second wireless signal including instructions that, when received by the radio, cause the electronic circuit system to produce a second alarm, the second alarm including at least one of an audible output or a visual output.2. The method of claim 1 , wherein the medicament delivery device is any one of an auto-injector claim 1 , a nasal delivery device or an inhaler.3. The method of claim 1 , further comprising:determining, based at least in part on the first wireless signal, a location of the medicament delivery device; andproducing, via the computing device, a location alert indicating the location.4. The method of claim 1 , further comprising:receiving a third wireless signal from the radio, the third wireless signal associated ...

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Номер записи: 59
09-02-2017 дата публикации

NICOTINE POWDER INHALER

Номер: US20170035107A1
Автор: ZINOVIK Ihar Nikolaevich, ZUBER Gerard
Принадлежит:

This disclosure relates to nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime. 1. A nicotine powder inhaler comprising:a body extending between a mouthpiece portion and a distal end portion;an airflow channel extending between the mouthpiece portion and a distal end portion;a nicotine powder receptacle comprising a dose of nicotine powder and disposed along the airflow channel;wherein the dose of nicotine powder can be inhaled into lungs of a user at an inhalation rate of less than about 5 L/min.2. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder receptacle is configured to receive a capsule containing nicotine powder.3. A nicotine powder inhaler according to claim 2 , further comprising opposing piercing elements configured to pierce the received capsule and fluidly connect the nicotine powder with the airflow channel.4. A nicotine powder inhaler according to claim 1 , wherein the airflow channel extends linearly along the body from the distal end portion to the mouthpiece portion.5. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder is a nicotine salt.6. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder is nicotine bitartrate claim 1 , nicotine salicylate claim 1 , nicotine fumarate claim 1 , nicotine mono-pyruvate claim 1 , or nicotine hydrochloride.7. A nicotine powder inhaler according to claim 1 , wherein at least about 90 wt % of the nicotine powder has a particle size of about 10 micrometers or less.8. A nicotine powder inhaler according to claim 1 , further comprising a swirl generator element configured to induce rotational movement in the airflow from the airflow channel.9. A nicotine powder inhaler according to claim 1 , further comprising a second airflow channel extending between the mouthpiece portion and a distal end portion and a second powder receptacle and disposed along the second airflow channel.10. A ...

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Номер записи: 60
11-02-2016 дата публикации

Medical therapy using cigarettes

Номер: US20160037823A1
Автор: Ruben Aari
Принадлежит:

The invention is a medical treatment mechanism. Using an organic material which is ignited and inhaled by a patient, such as tobacco or cannabis, a breakable capsule containing the medicine is contained and selectively released so that heat from the ignited organic material activates the medicine. The medicine is released, ideally by the patient breaking the capsule, the medicine is inhaled by the patient for treatment of a medical condition. 1. A medical treatment apparatus comprising:a) a quantity of organic material adapted to be ignited and inhaled by a patient; and,b) at least one breakable capsule interposed between the ignited organic material and a patient's lungs, said breakable capsule containing a quantity of medicine, said medicine being enhanced by heat from the ignited organic material.2. The medical treatment apparatus according to claim 1 , wherein said at least one breakable capsule is adapted to be broken by a user to release the medicine.3. The medical treatment apparatus according to claim 2 , wherein said medicine is in oil form.4. The medical treatment apparatus according to claim 3 , wherein said medicine includes oil from cannabinoids.5. The medical treatment apparatus according to claim 3 , wherein said medicine includes Eucalyptus oil.6. The medical treatment apparatus according to claim 3 , wherein said medicine includes essential oils.7. The medical treatment apparatus according to claim 3 , wherein said medicine includes rose oils.8. The medical treatment apparatus according to claim 3 , wherein said organic material is contained within a cigarette and wherein said at least one breakable capsule is contained within a cigarette filter attached thereto.9. The medical treatment apparatus according to claim 8 , wherein said organic material includes a quantity of marijuana.10. The medical treatment apparatus according to claim 8 , wherein said organic material includes a quantity of tobacco.11. The medical treatment apparatus according to ...

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Номер записи: 61
08-02-2018 дата публикации

CARTRIDGE, COMPONENTS AND METHODS FOR GENERATING AN INHALABLE MEDIUM

Номер: US20180035719A1
Автор: DICKENS Colin, TURNER Dominic
Принадлежит:

A cartridge is provided for use with an apparatus for generating an inhalable medium. The cartridge has a container for holding a liquid and a receptacle for receiving a solid material. A shell is provided around the outside of the liquid container. A channel is defined between the liquid container and the shell. Liquid exiting the container can flow, in the form of at least one of a vapor and an aerosol, through the channel to the receptacle and through solid material received by the receptacle in use. 1. A cartridge for use with an apparatus for generating an inhalable medium , the cartridge comprising:a liquid container for holding a liquid;a receptacle for receiving a solid material; anda shell around the outside of the liquid container,wherein the shell and the liquid container define between them a channel, and wherein the cartridge is arranged such that in use liquid exiting the liquid container can flow, in the form of at least one of a vapor or an aerosol, through the channel to the receptacle and through solid material received by the receptacle in use.2. A cartridge according to claim 1 , wherein the cartridge has a single substantially tubular channel defined between the liquid container and the shell.3. A cartridge according to claim 1 , wherein the cartridge has plural channels defined between the liquid container and the shell.4. A cartridge according to claim 1 , wherein the channel is an annular channel defined between the liquid container and the shell and substantially surrounding the liquid container.5. A cartridge according to claim 1 , wherein the liquid container is frustoconical.6. A cartridge according to claim 1 , comprising a heater associated with the liquid container for volatilizing a liquid held in the liquid container in use.7. A cartridge according to claim 1 , comprising a heater associated with the receptacle for heating a solid material received by the receptacle in use.8. A cartridge according to claim 1 , wherein the liquid ...

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Номер записи: 62
09-02-2017 дата публикации

AEROSOL GENERATOR INCLUDING MULTI-COMPONENT WICK

Номер: US20170035924A1
Автор: WRENN Susan E., YANG Zuyin
Принадлежит: Philip Morris USA Inc.

An aerosol generator includes a composite conduit to transport multiple liquids to a heating element at flow rates such that the liquids arrive at the heating element in desirable concentrations. The heating element volatilizes the liquids to form volatilized fluid, which mixes with ambient air to form an aerosol with desirable concentrations of the multiple liquids. 222-. (canceled)23. An aerosol generator comprising:a reservoir containing a liquid material;at least one wick in fluid communication with the reservoir;a heating element configured to heat the liquid material in the at least one wick to form an aerosol, the heating element including a serpentine strip; anda power supply electrically connectable to the heating element.24. The aerosol generator of claim 23 , wherein the heating element is formed of stainless steel.25. The aerosol generator of claim 23 , wherein the at least one wick includes a first wick and a second wick.26. The aerosol generator of claim 25 , wherein the first wick and the second wick have different lengths.27. The aerosol generator of claim 25 , wherein the first wick and the second wick are formed of different wicking materials.28. The aerosol generator of claim 23 , wherein the heating element is embedded in the at least one wick.29. The aerosol generator of claim 23 , wherein the power supply includes a battery.30. The aerosol generator of claim 23 , further comprising:a mouthpiece through which the aerosol passes.31. The aerosol generator of claim 23 , further comprising:a control circuit configured to regulate a supply of power from the power supply to the heating element.32. The aerosol generator of claim 23 , wherein the liquid material comprises:at least one of an aerosol former and a flavor system.33. The aerosol generator of claim 31 , wherein the aerosol former comprises:at least one of propylene glycol and glycerol. This application is a continuation application of U.S. application Ser. No. 12/576,951 entitled AEROSOL ...

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Номер записи: 63
09-02-2017 дата публикации

Medicament delivery device for administration of opioid antagonists including formulations for naloxone

Номер: US20170035957A1
Автор: Eric S. Edwards, Evan T. Edwards, Frank E. Blondino, Mark J. Licata
Принадлежит: kaleo Inc

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

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Номер записи: 64
12-02-2015 дата публикации

PULSATING INHALER AND A METHOD OF TREATING UPPER RESPIRATORY DISORDERS

Номер: US20150040891A1
Автор: Avni Yuval
Принадлежит:

A pulsating inhaler comprising: (a) a fluid oscillator providing focused fluid columns with a series of alternating high and low pressure zones and (b) at least one outlet orifice adapted for delivering said focused fluid column to the respiratory tract of said patient. The fluid oscillator further comprises a piston which is actuated by a motor with an eccentric mechanism. According to alternative embodiment of the invention, the fluid oscillator comprises a rotating disc having a missing section. 1. A pulsating inhaler comprising:a. a fluid oscillator providing focused fluid columns with a series of alternating high and low pressure zones and{'b': '211', 'b. at least one outlet orifice () adapted for delivering said focused fluid column to the respiratory tract of said patient,'}{'b': 203', '203, 'wherein said fluid oscillator comprises a piston () which is actuated by a motor with an eccentric mechanism ().'}2. The inhaler according to further comprising a medicament dispenser dispensing fixed amounts of at least one medicament and injecting said fixed amounts of said at least one medicament into said focused fluid column.3. The inhaler according to further comprising a fluid dispenser fluidly coupled to said fluid oscillator.4. The inhaler according to claim 1 , wherein said medicament dispenser is activated before said fixed amounts of said at least one medicament is transported by said focused fluid column.5. The inhaler according to claim 1 , wherein said medicament is dispensed by puncturing a disposable capsule such that a fixed amount of said medicament is injected into said focused fluid column.6. A pulsating inhaler comprising:a. a fluid oscillator providing focused fluid columns with a series of alternating high and low pressure zones and{'b': '305', 'b. at least one outlet orifice () adapted for delivering said focused fluid column to the respiratory tract of said patient,'}{'b': '308', 'wherein said fluid oscillator comprises a rotating disc () having ...

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Номер записи: 65
12-02-2015 дата публикации

NEBULIZER

Номер: US20150040893A1
Автор: ARGAUER Herbert, Besseler Jens, GATZ Josef, GORSHOEFER Andreas, Herrmann Frank, HOLAKOVSKY Holger
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

A nebulizer is proposed which comprises a blocking device for blocking opening of the nebulizer in a tensioned state. The nebulizer comprises preferably an indicator device for indicating a tensioned state of the nebulizer. The nebulizer comprises further a depressible actuator member at a housing part which is detachable from the nebulizer. 112. A nebulizer () for a fluid () , comprising:{'b': 3', '2, 'a container () containing the fluid (),'}{'b': 18', '3, 'a housing which can be opened, preferably by detaching a housing part (), for replacing the container (),'}{'b': '2', 'a delivery mechanism for dispensing the fluid (),'}characterized in{'b': 1', '68', '1', '50', '52', '53, 'that the nebulizer () comprises a blocking device () adapted to block, when the nebulizer () is in a tensioned or loaded state, opening of the housing and/or indexing of an indicator member () which shows numbers () and/or symbols (), and/or'}{'b': 1', '73', '1, 'that the nebulizer () comprises an indicator device () for indicating a tensioned or loaded state of the nebulizer (), and/or'}{'b': 1', '79', '18', '18', '79', '3', '79, 'that the nebulizer () comprises a manually depressible actuator member () at a housing part (), wherein the housing part () is detachable together with the actuator member () from the housing for replacing the container () when the actuator member () is depressed and, in particular, when opening of the housing is not blocked.'}2128. The nebulizer according to claim 1 , characterized in that the nebulizer () is ready to dispense a dose of the fluid () in the tensioned state automatically when actuating a stop element ().32. The nebulizer according to claim 1 , characterized in that the delivery mechanism comprises an energy store for pressurizing and/or dispensing the fluid ().471. The nebulizer according to claim 3 , characterized in that the energy store is a drive spring () tensioned in the tensioned state of the nebulizer ().532. The nebulizer according to ...

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Номер записи: 66
24-02-2022 дата публикации

RESPIRATORY INHALER CARTRIDGE PLACEMENT TRAINING DEVICE

Номер: US20220054774A1
Автор: Baker Jeff, HOU Shishuang, Liu Tingting, MAZZARELLA Tara
Принадлежит:

In one embodiment, a resettable respiratory inhaler training device is provided herein. The resettable respiratory inhaler training device includes a device housing having an unlocked position and a locked position, the housing comprising a chamber; a cartridge for placement into the chamber, the cartridge comprising a body for insertion into the chamber and a base, said cartridge including a status indicator window to indicate a new or used cartridge, an aperture in the base and a shutter to selectively open or close the aperture; and a reset cap comprising a protrusion for interfacing with the aperture during reset of the device; wherein operation of the device changes the status indicator window from used to new to reset the cartridge for a subsequent use. 1. A resettable respiratory inhaler training device , comprising;a device housing comprising an unlocked position and a locked position, the housing comprising a chamber;a cartridge for placement into the chamber, the cartridge comprising a body and a base, wherein the body is receivable within the chamber, said cartridge comprises a status indicator window to indicate a new or used status of the cartridge, an aperture in the base of the cartridge, and a shutter to selectively open or close the aperture; anda reset cap comprising a protrusion for interfacing with the aperture during reset of the device;wherein removal of the cartridge from the device housing changes the status in the indicator window from the used status to the new status and resets the cartridge for a subsequent use.2. The resettable respiratory inhaler training device of claim 1 , wherein the device housing comprises an upper portion and a lower portion claim 1 , wherein the device housing lower portion is rotatable relative to the upper portion.3. The resettable respiratory inhaler training device of claim 2 , further comprising a biasing member associated with the lower portion of the device housing claim 2 , for rotating the lower portion ...

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Номер записи: 67
24-02-2022 дата публикации

SMART MASKS

Номер: US20220054867A1
Автор: Adams William
Принадлежит:

A smart mask includes a face covering, an attachment member, one or more sensors, and a controller. The face covering is configured to cover a face area of a wearer. The attachment member is configured to attach the face covering onto the face area of the wearer. The one or more sensors comprises an air quality sensor configured to obtain first data associated with nearby air quality or a breathing pattern sensor configured to obtain second data associated with the wearer's breathing pattern. The controller is configured to process the first data associated with nearby air quality to identify a current air quality, or process the second data obtained by the breathing pattern. In response to determining that the current air quality is worse than a predetermined threshold, or identifying a particular breathing pattern, the controller is configured to generate a notification, notifying the wearer. 1. A smart mask , comprising:a face covering configured to cover a face area of a wearer;an attachment member configured to attach the face covering onto the face area of the wearer;one or more sensors, the one or more sensors comprising at least (1) an air quality sensor configured to obtain first data associated with nearby air quality or (2) a breathing pattern sensor configured to obtain second data associated with the wearer's breathing pattern; and{'claim-text': ['process the first data obtained by the air quality sensor to determine a current air quality, or process the second data obtained by the breathing pattern sensor to identify one of a plurality of breathing patterns of the wearer, and', 'in response to determining that the current air quality reaches a predetermined threshold, or identifying a particular breathing pattern, generate a notification.'], '#text': 'a controller configured to:'}2. The smart mask of claim 1 , wherein the controller is configured to:determine an indoor air quality (IAQ) index based on the data obtained by the air quality sensor; andin ...

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Номер записи: 68
07-02-2019 дата публикации

HIGH FREQUENCY POLARIZATION AEROSOL GENERATOR

Номер: US20190037925A1
Автор: Hon Lik, Li Zhuoran
Принадлежит:

A vaporizing device such as an electronic cigarette includes a housing () containing a battery () or other electrical power source electrically connected to a high frequency oscillation circuit (). Two electrodes or electrode pads () with a liquid space () between them are electrically connected to the high frequency oscillation circuit (). A liquid supply () in the C housing () provides a liquid into the liquid space (). The high frequency oscillation circuit () is switched on by a manual switch or by a sensor () sensing inhalation by a user. The liquid is vaporized by dielectric heating. 1. A vaporizing device comprising:a housing containing an electrical power source electrically connected to a high frequency oscillation circuit;first and second electrodes electrically connected to the high frequency oscillation circuit, with a liquid space between the first and second electrodes;a liquid supply in the housing positioned to provide a polar liquid into the liquid space; anda switch electrically connected to the high frequency oscillation circuit for turning on the high frequency oscillation circuit to vaporize the liquid via dielectric heating.2. The device of wherein the switch comprises an inhalation sensor connected to an electronic controller.3. The device of with the first and second electrodes comprising first and second electrode pads including a first insulator on the first electrode and a second insulator on the second conductor claim 1 , respectively.4. The device of wherein the liquid space is annular.5. The device of wherein the liquid space is dimensioned to allow liquid to flow into the liquid space via capillary forces.6. The device of wherein the liquid comprises propylene glycol claim 1 , glycerol or vegetable glycerin.7. The device of wherein the liquid has a dipole moment of 1.0 to 8.0 Debyes.8. The device of wherein the liquid has a dipole moment 1.0 to 4.0.9. The device of wherein the power source comprises a battery.10. The device of wherein ...

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Номер записи: 69
07-02-2019 дата публикации

DEVICE AND A METHOD FOR CONTROLLED ADMINISTERING OF A THERAPEUTIC COMPOSITION TO A PATIENT

Номер: US20190038853A1
Автор: Eyal Aharon M., SARID Shay Avraham
Принадлежит: CANABOLABS

Controlling device particularly adapted for administering a therapeutic composition, that includes (i) a power input element configured to connect with and receive power from a power source; (ii) a power adjustment device connected to said power input element optionally comprising a data input element connected to a data processing device; (iii) a power output element connected to said power adjustment device and configured to connect with and provide power to a processing element; optionally (iv) a data output element connected to the data processing device and connected to said power output element; wherein said power output element is configured to be controlled by said power adjustment device and wherein said controlling device is configured to be readily removable from the power source and the processing element. 1. A controlling device particularly adapted for administering a therapeutic composition , comprising (i) a power input element configured to connect with and receive power from a power source; (ii) a power adjustment device connected to said power input element optionally comprising a data input element connected to a data processing device; (iii) a power output element connected to said power adjustment device and configured to connect with and provide power to a processing element; optionally (iv) a data output element connected to the data processing device and connected to said power output element; optionally (vi) a power-storing device configured to couple with said power input element , and optionally (vii) an electric transformer configured to couple with a power source , wherein said power output element is configured to be controlled by said power adjustment device and wherein said controlling device is configured to be readily removable from the power source and the processing element.2. A controlling device according to claim 1 , wherein said processing element comprises a controllable unit selected from a heating unit claim 1 , a gas or ...

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Номер записи: 70
06-02-2020 дата публикации

VAPORIZER WITH A PH SENSOR

Номер: US20200038603A1
Автор: Minskoff Noah Mark, Terry Nathan Andrew
Принадлежит: RAI STRATEGIC HOLDINGS, INC.

A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. A pH sensor detects a pH value of the substance to be vaporized for preventing use of an improper substance. When the pH value is confirmed, the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized. 1. A personal vaporizer comprising:a cartridge with a substance to be vaporized;a wick in contact with the substance to be vaporized from the cartridge;a pH sensor configured to determine a pH level of the substance in the cartridge; anda heating element configured to heat the substance in the wick for vaporization during activation, wherein the activation occurs when the determined pH level satisfies a defined pH criterion.2. The personal vaporizer of claim 1 , wherein the defined pH criterion comprises one of a pH value or a pH range.3. The personal vaporizer of claim 2 , wherein the activation is prevented when the determined pH level of the substance fails to satisfy the defined pH criterion.4. The personal vaporizer of claim 3 , wherein a pH level for substances that are not authentic or not proprietary fail to satisfy the defined pH criterion claim 3 , and the defined pH criterion is stored as a profile that comprises pH ranges for each of the substances that are authentic or proprietary.5. The personal vaporizer of claim 1 , further comprising:an air inlet for outside air transfer;a mouthpiece for the air flow after the vaporization; andan atomizer housing supporting the wick with the heating element and forming an air gap for the vaporization, wherein the atomizer housing further comprises an air hole for air flow.6. The personal vaporizer of claim 1 , wherein the pH sensor is further configured for detecting ...

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Номер записи: 71
06-02-2020 дата публикации

Inhaler spacer

Номер: US20200038604A1
Автор: Srinivasan JANARDHANAN, Vidur Malhotra
Принадлежит: Cipla Ltd

The invention relates to an inhaler spacer (1) comprising an inlet (2) for connection to an inhaler and an outlet (4) through which a user can inhale. The inhaler spacer (1) comprises a duct (6) extending between the inlet (2) and the outlet (4). The duct (6) is defined by a wall (8) which extends around a first axis (10) and comprises a diffuser portion (12) extending along the first axis away from the inlet. The wall (8) of the duct (6) in at least apart of the diffuser portion curves outwardly away from the first axis with increasing distance away from the inlet such that the cross sectional area of the diffuser portion perpendicular to the first axis increases with increased distance from the inlet along the first axis.

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Номер записи: 72
18-02-2021 дата публикации

Aerosol-generating system comprising a modular assembly

Номер: US20210045438A1
Автор: Tony Reevell
Принадлежит: Altria Client Services LLC

An aerosol-generating system includes a plurality of cartridges and an aerosol-generating device. At least one cartridge of the plurality of cartridges includes a first aerosol-forming substrate, the plurality of cartridges are configured for selective connection to each other to form a cartridge assembly. The aerosol-generating device includes a storage including a second aerosol-forming substrate in the storage, an electric heater configured to heat a portion of the second aerosol-forming substrate from the storage section during use of the aerosol-generating system, and a power supply housing, the power supply housing including a power supply and a controller, the controller configured to control a supply of electrical power from the power supply to the electric heater, the aerosol-generating device being configured to receive the cartridge assembly at a downstream end of the aerosol-generating device.

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Номер записи: 73
18-02-2021 дата публикации

DEVICE AND METHOD FOR ADMINISTERING AN ACTIVE INGREDIENT

Номер: US20210046041A1
Автор: LEVY Kurt
Принадлежит:

This disclosure pertains to devices and methods for administering one or more active ingredients, e.g., cannabinoids, terpenes, etc. In particular, the devices and methods disclosed herein administer one or more cannabinoids in a mist for transmucosal and transdermal absorption. In one embodiment, the device contains compositions comprising purified active ingredients (e.g., cannabinoids, terpenes, etc.) and/or unique combinations thereof for delivery via a mist for transmucosal and transdermal adsorption. In one embodiment, the device contains two separate compositions in separate chambers, wherein each composition comprises one or more of the active ingredients. In one embodiment, a composition in one chamber comprises a purified cannabinoid and the composition in the other chamber comprises a purified terpene. In an embodiment, the device operates without heating the active ingredients. 2. (canceled)3. The device of claim 1 , wherein the cannabinoid is purified.4. The device of claim 3 , wherein the purified cannabinoid is THC claim 3 , Δ9-THC claim 3 , Δ8-THC claim 3 , THCA claim 3 , THCV claim 3 , Δ8-THCV claim 3 , Δ9-THCV claim 3 , THCVA claim 3 , CBD claim 3 , CBDA claim 3 , CBDV claim 3 , CBDVA claim 3 , CBC claim 3 , CBCA claim 3 , CBCV claim 3 , CBCVA claim 3 , CBG claim 3 , CBGA claim 3 , CBGV claim 3 , CBGVA claim 3 , CBN claim 3 , CBNA claim 3 , CBNV claim 3 , CBNVA claim 3 , CBND claim 3 , CBNDA claim 3 , CBNDV claim 3 , CBNDVA claim 3 , CBE claim 3 , CBEA claim 3 , CBEV claim 3 , CBEVA claim 3 , CBL claim 3 , CBLA claim 3 , CBLV claim 3 , or CBLVA.5. (canceled)6. (canceled)7. (canceled)8. The device of claim 1 , wherein the first composition comprises a first active ingredient and the second composition comprises a second active ingredient claim 1 , wherein at least one of the first active ingredient and the second active ingredient is the cannabinoid.9. The device of claim 8 , wherein the first active ingredient and the second active ingredient are ...

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Номер записи: 74
18-02-2016 дата публикации

Systems, methods, and devices to incentivize inhaler use

Номер: US20160045681A1
Автор: Cheatham, Hyde Roderick A., III Jesse R., JR. Lowell L., Petroski Robert C., Wood, Wood Victoria Y.H.
Принадлежит:

The present disclosure relates to systems, methods, and devices that may be used to incentivize inhaler use. 1. An inhaler comprising:a housing having at least one flow channel disposed therein;at least one port disposed in the housing and operably coupled to the at least one flow channel and configured to provide fluid communication between at least two agent containing reservoirs and the at least one flow channel;one or more sensors operably coupled with the at least one flow channel;at least one actuator configured to independently facilitate at least partial release of at least one agent from each of at least two agent containing reservoirs when the at least two agent containing reservoirs are each operably coupled to the at least one port; andone or more control units configured to receive information from the one or more sensors, wherein the one or more control units control operation of the at least one actuator in response to the information received from the one or more sensors.211.-. (canceled)12. The inhaler of claim 1 , wherein the one or more sensors operably coupled with the at least one flow channel comprise:at least one sensor configured to assess one or more values associated with one or more respiration parameters.13. (canceled)14. The inhaler of claim 1 , wherein the one or more sensors operably coupled with the at least one flow channel comprise:at least one flow sensor.1518.-. (canceled)19. The inhaler of claim 1 , wherein the one or more sensors operably coupled with the at least one flow channel comprise:at least one sensor configured to assess flow of at least one agent through the at least one flow channel.2021.-. (canceled)22. The inhaler of claim 1 , wherein the at least one actuator configured to independently facilitate at least partial release of at least one agent from each of at least two agent containing reservoirs when the at least two agent containing reservoirs are each operably coupled to the at least one port comprise:at least ...

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Номер записи: 75
18-02-2016 дата публикации

METHODS, SYSTEMS, AND DEVICES RELATED TO DELIVERY OF ALCOHOL WITH AN INHALER

Номер: US20160045682A1
Автор: Boyden Edward S., Hyde Roderick A., JR. Lowell L., Kare Jordin T., Pan Tony S., Petroski Robert C., Sweeney Elizabeth A., Wood
Принадлежит:

The present disclosure relates to devices, systems, and methods that may be used to controllably deliver alcohol to a subject using an inhaler. 1. An inhaler , comprising:a housing having at least one flow channel disposed therein configured to be fluidly coupled to at least one ethanol-containing inhalant reservoir;at least one actuator configured to facilitate at least partial release of at least one ethanol-containing inhalant from at least one ethanol-containing inhalant reservoir into the at least one flow channel; and accept one or more parameters associated with a subject;', 'access or create an ethanol-containing inhalant delivery regimen associated with the subject in response to the one or more parameters; and', 'control operation of the at least one actuator to facilitate at least partial release of the at least one ethanol-containing inhalant from the ethanol-containing inhalant reservoir into the at least one flow channel in response to the ethanol-containing inhalant delivery regimen associated with the subject., 'at least one control unit including at least one processing component configured to;'}26.-. (canceled)7. The inhaler of claim 1 , further comprising:at least one ethanol-containing inhalant reservoir including at least one aerosol canister having a canister body and a valve stem that extends from the canister body, andwherein the housing includes at least one reservoir support configured to support the at least one aerosol canister with the valve stem being received by the at least one port.8. The inhaler of claim 1 , wherein the at least one actuator comprises:at least one aerosol canister content release mechanism.9. The inhaler of claim 1 , wherein the at least one control unit configured to accept one or more parameters associated with a subject comprises:at least one control unit configured to accept one or more physical parameters associated with the subject.10. (canceled)11. The inhaler of claim 1 , wherein the at least one control ...

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Номер записи: 76
18-02-2016 дата публикации

SYSTEMS, METHODS, AND DEVICES TO INCENTIVIZE INHALER USE

Номер: US20160045683A1
Автор: Cheatham, Hyde Roderick A., III Jesse R., JR. Lowell L., Petroski Robert C., Wood, Wood Victoria Y.H.
Принадлежит:

The present disclosure relates to systems, methods, and devices that may be used to incentivize inhaler use. 1211.-. (canceled)212. A system comprising:means for assessing one or more parameters associated with use of an inhaler by a subject;means for administering at least one active agent to the subject in response to assessing the one or more parameters associated with use of the inhaler; andmeans for administering at least one incentive agent to the subject in coordination with administering the at least one active agent.213. The system of claim 212 , further comprising:means for displaying a comparison of an assessed value associated with one or more respiration parameters with one or more levels associated with the one or more respiration parameters.214. The system of claim 212 , further comprising:means for instructing the subject to achieve one or more values associated with one or more respiration parameters.215. The system of claim 212 , further comprising:means for accepting information associated with one or more parameters associated with the subject.216. The system of claim 212 , further comprising:means for assessing one or more parameters associated with administering the at least one active agent to the subject.217. The system of claim 212 , further comprising:means for assessing one or more parameters associated with administering the at least one incentive agent to the subject.218. The system of claim 216 , further comprising:means for predicting one or more locations in the pulmonary tract of the subject where the at least one active agent was delivered in response to the one or more parameters associated with administration of the at least one active agent to the subject.219. The system of claim 217 , further comprising:means for predicting one or more locations in the pulmonary tract of the subject where the at least one incentive agent was delivered in response to the one or more parameters associated with administration of the at least one ...

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Номер записи: 77
16-02-2017 дата публикации

DELIVERY DEVICES

Номер: US20170043108A1
Автор: Andreassen Erik, Djupesland Per Gisle, Gaarder Rune Harald, Nilsson Andreas, Péricé Christophe
Принадлежит:

A delivery device for delivering a metered amount of substance (L) in response to exhalation by a user, the delivery device comprising: a mouthpiece () through which the user in use exhales; an outlet () from which substance Is delivered; and a dispensing unit () which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member () which includes a cavity () for containing a metered amount of substance, an outlet nozzle () which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing () member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle. 1. A delivery device for delivering a metered amount of a substance in response to exhalation by a user , the delivery device comprising:a mouthpiece adapted for a user to exhale through;an outlet from which the substance is delivered; anda dispensing unit operable to dispense a metered amount of the substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member, the body member including a cavity for containing a metered amount of the substance, an outlet nozzle fluidly connected to the cavity from which the substance is delivered, and a dispensing member movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, causing substance to be delivered from the outlet nozzle;whereby the exhalation of the user creates an exhalation flow that directly acts on the dispensing member.2. The delivery device of claim 1 , wherein the cavity is an elongate cavity.3. The delivery device of claim 2 , wherein the cavity has a cylindrical section and the dispensing member ...

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Номер записи: 78
03-03-2022 дата публикации

Device for tableting a powder, liquid, paste, encapsulated or granular active ingredient composition

Номер: US20220062108A1
Автор: Fritz Schmitt
Принадлежит: Individual

The invention relates to a device for tabletting a powdered, liquid, pasty, encapsulated or granular active ingredient composition, having a magazine which has a plurality of active ingredient containers each with an individually controllable dosing device and a nozzle for the active ingredient outlet, wherein the magazine is adjustable between a plurality of setting positions relative to at least one die chamber, wherein in each of the setting positions at least one of the nozzles faces an opening of the die chamber. A corresponding method is further described.

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Номер записи: 79
14-02-2019 дата публикации

DEVICES FOR EVAPORATION AND INHALATION OF NICOTINE

Номер: US20190046743A1
Автор: Engqvist Hakan
Принадлежит:

There is provided an inhalation device for delivering a deliverable agent in the form of an aerosol or vapor to a user. The device comprises a solid, porous carrier material having a defined porosity, and a deliverable agent located within the pores of the carrier material. The device is operable to heat the carrier material and vaporize the deliverable agent. Deliverable agents that may be delivered to the user include nicotine. Suitable materials for the porous carrier material include chemically bonded ceramic materials and geopolymeric materials. 1. A device for delivering a deliverable agent in the form of an aerosol or vapor to a user , said device comprising a solid , porous carrier material having a porosity of at least 10% , and a deliverable agent located within the pores of the carrier material , wherein the device is operable to heat the carrier material and vaporize the deliverable agent.2. The device according to claim 1 , wherein the solid claim 1 , porous carrier material has a porosity of from about 20% to about 70%.3. The device according to claim 1 , wherein the average pore size in the carrier material is from about 0.1 μm to about 500 μm.4. The device according to wherein the deliverable agent is located predominantly within the pores of the carrier material.5. The device according to claim 1 , wherein the carrier material is based on one or more chemically bonded ceramic materials claim 1 , one or more geopolymeric materials or one or more metals.6. The device according to claim 5 , wherein the carrier material is selected from the list consisting of:(i) a material obtainable by the process of reacting an aluminosilicate precursor material with an aqueous alkaline liquid; and(ii) a calcium phosphate, a calcium sulfate, a calcium carbonate, a calcium silicate, a calcium aluminate, a magnesium carbonate, an aluminium silicate, and combinations thereof.7. The device according to claim 5 , wherein the carrier material is (i) selected from the group ...

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Номер записи: 80
25-02-2021 дата публикации

Use of antistatic materials in the airway for thermal aerosol condensation process

Номер: US20210052830A1
Автор: Daniel J. Myers, James Cassella, Khe KUBEL
Принадлежит: Alexza Pharmaceuticals Inc

The disclosure teaches the use of antistatic materials in the airway for thermal aerosol generation devices. The present disclosure teaches the use of antistatic materials for drug delivery in any drug that may be susceptible to charging during aerosol generation.

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Номер записи: 81
10-03-2022 дата публикации

NOSE BRIDGE STRIP WITH SCENT RELEASING MECHANISM AND MASK STRUCTURE HAVING THE SAME

Номер: US20220072342A1
Автор: TSAI Cheng-Lang
Принадлежит:

A nose bridge strip having a scent-releasing mechanism can be included in a mask structure and includes a main body and at least one scent-releasing element. The main body is in a shape of a strip and can be combined with the scent-releasing element. The scent-releasing element can produce scent molecules capable of reacting with olfactory cells in a nasal cavity such that bioelectric waves are generated and propagate to the brain. The mask structure includes the nose bridge strip and a mask body that can be arranged with the nose bridge strip. When the mask body is worn on a human face, the nose bridge strip can be pressed and deformed compliantly against the nose bridge so that a user wearing the mask structure can smell a pleasant scent while breathing and feel comfortable. 1. A nose bridge strip having a scent releasing mechanism , comprising:a main body in a shape of a strip and configured to be fixed on or in a mask body at a location corresponding to a nose bridge on a human face when the mask body is worn on the human face and be pressed and deformed compliantly against the nose bridge; andat least one scent releasing element configured to be combined with the main body and produce scent molecules capable of reacting with olfactory cells in a nasal cavity.2. The nose bridge strip according to claim 1 , wherein the main body is made of a plastic material claim 1 , and the scent releasing element solidified from a liquid state is mixed with the main body to form the nose bridge strip.3. The nose bridge strip according to claim 1 , wherein the scent releasing element is in a shape of a film and fixed on a side surface of the main body in a winding or weaving configuration or by adhesive bonding.4. The nose bridge strip according to claim 1 , wherein the scent releasing element is fixed on a side surface of the main body by directly applying the scent releasing element to the side surface or dipping the main body in a mixture including the scent releasing ...

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Номер записи: 82
21-02-2019 дата публикации

FORMULATION AND AEROSOL CANISTERS, INHALERS, AND THE LIKE CONTAINING THE FORMULATION

Номер: US20190054010A1
Автор: COCKS PHILIP M., DEXTER SARAH J., SLOWEY ALEXANDER D.
Принадлежит:

Compositions containing tiotropium or a pharmaceutically acceptable salt or solvate thereof, citric acid or a salt thereof, glycerol, ethanol, and a propellant, as well as aerosol canisters and inhalers containing the same. Methods of manufacturing and using the compositions, aerosol canisters, and inhalers. 1. A composition comprisingtiotropium or a pharmaceutically acceptable salt or solvate thereof in a concentration of 0.0075 wt % to 0.015 wt % based on the weight of tiotropium bromide;citric acid or a salt thereof in a concentration greater than 0.10 wt % and no greater than 0.2 wt % based on the weight of free citric acid;glycerol in a concentration of 0.5 wt % to 2.0 wt %;ethanol in a concentration of up to 20 wt %; anda propellant consisting essentially of 1,1,1,2-tetrafluoroethane; wherein the formulation is a solution.2. The composition of claim 1 , wherein the tiotropium or a pharmaceutically acceptable salt or solvate thereof is tiotropium bromide.3. The composition of claim 1 , wherein the tiotropium is in a concentration of 0.09 wt % to 0.013 wt % based on the weight of tiotropium bromide.4. The composition of claim 1 , wherein the glycerol is in a concentration of 1.0 wt % to 1.5 wt %.5. The composition of claim 1 , wherein the ethanol is in a concentration of between 10 wt % and 20 wt %.6. The composition of claim 1 , wherein the ethanol is in a concentration of about 15%.7. The composition of claim 1 , wherein the citric acid or salt thereof is citric acid.8. The composition of claim 1 , wherein the citric acid or salt thereof is in a concentration of 0.125 wt % to 0.175 wt %.9. The composition of claim 1 , wherein the propellant comprises no less than 95% 1 claim 1 ,1 claim 1 ,1 claim 1 ,2-tetrafluoroethane.10. An aerosol canister containing the composition of .11. The aerosol canister of comprising an interior surface claim 10 , the interior surface having a coating thereon.12. An inhaler comprising the canister of .13. The inhaler of claim 12 , ...

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Номер записи: 83
01-03-2018 дата публикации

System, Method, and Apparatus for Delivery Through Inhalation

Номер: US20180056013A1
Автор: Knowles Kevin
Принадлежит:

A system for delivery of a material through inhalation includes a delivery cartridge having contained there within a breakable container. The breakable container has there within a payload such as a scent-bearing liquid (e.g. essential oil, perfume, etc.), medicinal liquid, etc. A device for flowing air/gases (e.g., a fan) forces air/gases through the delivery cartridge wherein after the breakable container is broken, the payload mixes with the air/gases for delivery to a user by way of inhalation. 1. A system for delivery of a material for inhalation , the system comprising:a delivery cartridge having contained there within a breakable container, the breakable container having there within a payload; andmeans for flowing a gas through the delivery cartridge;wherein after the breakable container is broken, the payload mixes with the gas for delivery to a user through inhalation.2. The system of claim 1 , wherein the system for delivery of a material for inhalation is worn by the user.3. The system of claim 1 , wherein the means for flowing the gas through the delivery cartridge includes a fan that draws the gas in through one or more vents claim 1 , through the delivery cartridge claim 1 , and out a grill in a direction of the user for inhalation by the user.4. The system of claim 1 , wherein the means for flowing the gas through the delivery cartridge operates at a first delay after the system for delivery of a material for inhalation is turned on.5. The system of claim 1 , wherein the means for flowing the gas through the delivery cartridge operates at a first delay after the system for delivery of a material for inhalation is turned on and until a second delay occurs claim 1 , at which time the means for flowing the gas through the delivery cartridge is stopped.6. The system of claim 1 , wherein the payload is an essential oil.7. The system of claim 1 , wherein the means for flowing the gas through the delivery cartridge comprises a fan.8. The system of claim 1 , ...

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Номер записи: 84
21-02-2019 дата публикации

DEVICE TO DELIVER CANNABIDIOL AND ASSOCIATED COMPOUNDS TO PROMOTE HEALTH

Номер: US20190054257A1
Автор: Becker Dean, Cameron John David, Fein Gene
Принадлежит:

An electronic vapor device including: a device processor operable for controlling the electronic vapor device; a container configured to store a vaporizable material; a vaporizing component, wherein the vaporizing component is in fluid communication with the container for receiving a selected amount of vaporizable material therefrom; at least one sensing component, wherein the at least one sensing component is configured to detect a plurality of status data associated with the vaporizable material; and wherein the device processor is further operable to: receive at least a portion of the detected status data from the at least one sensing component; determine at least one vaporizing configuration for vaporizing at least a portion of the vaporizable material received in the vaporizing component, and generate at least one vaporizing control signal for controlling at least one operational parameter of the electronic vapor device in accordance with the at least vaporizing configuration. 1. An electronic vapor device comprising:a device processor operable for controlling the electronic vapor device;a container configured to store a vaporizable material, wherein the vaporizable material comprises at least one cannabinoid compound;a vaporizing component operatively connected to the device processor and controlled in part by the device processor, wherein the vaporizing component is in fluid communication with the container for receiving a selected amount of vaporizable material therefrom, wherein the vaporizing component is operable to vaporize the vaporizable material received therein;a vapor outlet coupled to the vaporizing component and configured to receive at least a portion of vapor generated by the vaporizing component, wherein the vapor outlet is operable to expel the received vapor from the electronic vapor device;at least one sensing component operatively connected to the device processor and controlled in part by the device processor, wherein the at least one ...

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Номер записи: 85
21-02-2019 дата публикации

Columella Nasal Clip / Dilator for Aromatic Substances

Номер: US20190054263A1
Автор: Clifford S. Aboff
Принадлежит: Individual

A nasal clip and/or dilator which is U-shaped having protruding wider spherical/spheroid holders at each end of the U is designed to be placed such that each spherical holder is in a nostril. The U-shaped clip can press against the columella and each holder against the septum. Inside each holder is a scented piece, such as a plastic ball or cylinder with aromatic compounds there-in which exit from the surface of the respective scented piece. To facilitate the scent escaping from the scented piece and into the nose, each holder has portals such as around the circumference thereof and/or on opposite sides thereof, transverse to the “U” of the holder.

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Номер записи: 86
04-03-2021 дата публикации

INHALABLE DRY POWDERS

Номер: US20210060268A1
Автор: DeHaan Wesley H., LAWLOR Ciaran, Manzanedo Diana, Sung Jean C., Tauber Michael
Принадлежит:

The invention related to dry powders that contain a therapeutic agent. The dry powders have characterstics, e.g., they are processable and/or dense in therapeutic agent that provide advantages for formulating and delivering therapeutics agents to patients. 1128-. (canceled)129. A process for producing one or more receptacles with a respirable dry powder disposed therein , comprisingdisposing the respirable dry powder into a plurality of said receptacles at a target fill weight and at a rate of about one receptacle every 4 seconds or less to produce filled receptacles, wherein at least 80% of said filled receptacles contain said respirable dry powder within 85% to 115% of the target fill weight; andwherein the respirable dry powder consists of respirable dry particles that have a volume median geometric diameter (VMGD) of about 10 micrometers or less, and a tap density of at least 0.45 g/cubic centimeters, and wherein the respirable dry particles comprise a sodium salt and an antibiotic that provides at least 25% of the total mass of the contents disposed within the one or more receptacles, with the proviso that the respirable dry particles do not contain a divalent metal cation salt.130mycobacterium. The process of claim 129 , wherein the antibiotic is selected from the group consisting of a macrolide claim 129 , a tetracycline claim 129 , a fluoroquinolone claim 129 , a cephalosporin claim 129 , a penicillin claim 129 , an aminoglycoside claim 129 , a penem or carbapenem claim 129 , a monobactam claim 129 , an oxazolidinone claim 129 , an vancomycin claim 129 , a glycopeptide antibiotic and a tuberculosis-antibiotic.131. The process of claim 129 , wherein the antibiotic is a macrolide.132. The process of claim 131 , wherein the macrolide is selected from the group consisting of azithromycin claim 131 , clarithromycin claim 131 , and erythromycin.133. The process of claim 129 , wherein the antibiotic is a am inosalicylate claim 129 , cycloserine claim 129 , a ...

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Номер записи: 87
20-02-2020 дата публикации

Nasal Delivery Device and Methods of Use

Номер: US20200054843A1
Автор: LEVIN Bruce H.
Принадлежит:

The present invention relates to a medical device for intranasal delivery of a medicament. The medicament may be any type of medicament suitable for nasal administration and delivery in the form of a spray. The present invention ensures that a complete dosage of the medicament is delivered, especially to specific areas in the nasal cavity, such as the rear of the nasal cavity where the SPG is located. 1. A drug delivery system comprising: a housing configured to contain a medicament;a nozzle;a drug delivery mechanism to expel medicament from said nozzle;said nozzle having a bore and configured to direct the medicament to a predetermined area in the nasal passageway;said nozzle is in a retracted position prior to insertion into the nasal passageway; andwhen inserted into the nasal passageway said nozzle increases in length and extends into an extended position for delivery of the medicament.2. The drug delivery system of wherein said nozzle has a first surface area when in said retracted position and said nozzle has a second surface area when in said extended position; andsaid first surface area is less than said second surface area.3. The drug delivery system of wherein said nozzle creates a vortex of spray or a preconfigured plume.4. The drug delivery system of wherein said plume is circular.5. The drug delivery system of wherein said drug delivery mechanism is configured to have an adjustable pressure and said nozzle has an adjustable opening.6. The drug delivery system of wherein said drug delivery mechanism is a pump.7. The drug delivery system of wherein said nozzle contains one or more fins claim 2 , spirals claim 2 , helical elongated members claim 2 , rifling or grooves in the bore of the nozzle.8. The drug delivery system of wherein said nozzle contains solid structures in the bore to alter the flow.9. The drug delivery system of wherein said solid structures are conical claim 8 , spiral claim 8 , nautilus claim 8 , rain droplet shaped claim 8 , hi-conical ...

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Номер записи: 88
28-02-2019 дата публикации

MEDICAMENT DELIVERY DEVICE FOR ADMINISTRATION OF OPIOID ANTAGONISTS INCLUDING FORMULATIONS FOR NALOXONE

Номер: US20190060557A1
Автор: BLONDINO Frank E., EDWARDS Eric S., EDWARDS Evan T., LICATA Mark J.
Принадлежит: kaleo, Inc.

Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition. 1. A method , comprising:providing a naloxone composition configured for use in a medicament delivery device, the naloxone composition including a tonicity-adjusting agent, the pH of the naloxone composition ranging from 3 to 5; andassembling the medicament delivery device, the medicament delivery device including a housing, a medicament container disposed within the housing and defining an internal volume containing the naloxone composition, an elastomeric member that seals the naloxone composition within the medicament container, and a delivery member coupled to the medicament container, and the assembling including removably coupling a cover or case to the housing of the medicament delivery device.2. The method of claim 1 , wherein:the medicament delivery device is an auto-injector; andthe delivery member is a needle, the needle being coupled to the medicament container via a coupling member, the needle being fluidically isolated from the internal volume when the coupling member and the medicament container are in a first configuration, the needle in fluid communication with the internal volume when the coupling member and the medicament container are in a second configuration.3. The method of claim 1 , wherein:the medicament delivery device is an intranasal spray device; andthe delivery member is associated with an atomizer defining an orifice ...

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Номер записи: 89
28-02-2019 дата публикации

Devices and systems for air assisted dry powder administration

Номер: US20190060587A1
Автор: Gjertsen Jeffrey, Goodman Phillip, Hancock Jesse, Shaw Michael, Sullivan Timothy
Принадлежит:

The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The present dosage devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices. 1. A dry powder unit dose device , comprising:a dosage form comprising more than one blister well;wherein a blister well contains an internal piercing device; a blister well contains a dry powder, and the at least one additional blister well contains a gas propellant;wherein the at least one propellant containing blister well is in fluid communication with said a powder containing blister well upon rupture of a sealed interface between the a propellant containing blister well and the a powder containing blister well.2. The dry powder unit dose device of further comprising turbulence promoting features within the frangible sealed interface to aid in powder dispersion.3. The dry powder unit dose device of claim 2 , wherein the turbulence promoting feature of the frangible sealed interface between gas and powder containing blister wells comprises an elongated path channel.4. The dry powder unit dose device of claim 1 , wherein the dry powder and internal piercing device are contained in the same dispensing blister well.5. The dry ...

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Номер записи: 90
17-03-2022 дата публикации

ELECTRONIC BREATH ACTUATED DROPLET DELIVERY SYSTEMS WITH DOSE METERING CAPABILITIES, INHALATION TOPOGRAPHY METHODS, AND RELATED METHODS OF USE

Номер: US20220080137A1
Автор: Hebrank John H., Hunter Charles Eric
Принадлежит: Pneuma Respiratory, Inc.

Methods, devices and systems are provided wherein compositions are delivered to the pulmonary system of an intended user via inhalation in a controlled manner and at a desired doses and/or amounts, e.g., within a desired dosage window and/or inhalation topography. In certain embodiments, dosage windows and/or inhalation topography may be used, e.g., to provide for controlled cessation of use or to provide a desired therapeutic window. 1. A method for controlling the dose and/or amount of a composition for delivery to the pulmonary system of a user via inhalation , the method comprising:receiving, at a computing system based on user input, a request for a desired dose or amount of at least one agent or ingredient of a composition for delivery to the pulmonary system of a user via inhalation;at the computing system and in response to receiving the request, determining inhalation delivery device operating parameters to provide the requested desired dose or amount of at least one agent or ingredient of a composition for delivery to the pulmonary system of a user via inhalation;generating, at the computing system, instructions for activation and operation of an inhalation delivery device to provide the requested desired dose or amount based on the determined inhalation delivery device operating parameters; andtransmitting the instructions from the computing system to an ejector mechanism of an inhalation delivery device for execution at the inhalation delivery device to provide for activation and operation of the inhalation delivery device upon use to thereby control the dose and/or amount of the at least one agent or ingredient of a composition for delivery to the pulmonary system of user via inhalation.2. The method of claim 1 , wherein the request for a desired dose or amount comprises an inhalation topography to achieve a desired dosing regimen.3. The method of claim 2 , wherein the inhalation topography facilitates cessation of use.4. The method of claim 2 , wherein ...

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Номер записи: 91
12-03-2015 дата публикации

System for a Drug Delivery Device

Номер: US20150068524A1
Автор: Mayer Stefan
Принадлежит: SANOFI SA

A system comprising an opening aid for opening an inhaler and an inhaler, the opening aid comprising at least one opening member, wherein the inhaler comprises a first and a second exterior part which are connected to one another, wherein the exterior parts are separable by a movement including a relative rotational movement to prepare the inhaler for a dispensing operation, wherein the opening member is configured to be connected to one of the exterior parts in a torque-proof fashion, and wherein the first exterior part is a body comprising a dispensing opening through which a dose of drug can be dispensed from the body and the second exterior part is a cap which is releasably connectable to the body and, when connected to the body, covers the dispensing opening. 113-. (canceled)14. A system comprising an opening aid for opening an inhaler and an inhaler for dispensing a drug , the opening aid comprising two opening members , i.e. a first cover member and a second cover member , wherein the inhaler comprises a first and a second exterior part which are connected to one another , wherein the exterior parts are separable by a movement including a relative rotational movement to prepare the inhaler for a dispensing operation , whereinthe cover members are configured to be connected to one of the exterior parts in a torque-proof fashion, wherein the cover members are adapted to be connected to and to at least partly cover the two different exterior parts of the inhaler, whereinthe first exterior part is a body comprising a dispensing opening through which a dose of drug can be dispensed from the body and the second exterior part is a cap which is releasably connectable to the body and, when connected to the body, covers the dispensing opening, whereinthe opening members comprise one or more visual and/or tactile identification features, wherein the respective cover member is provided with an identification feature, and wherein the identification features are configured ...

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Номер записи: 92
10-03-2016 дата публикации

METHODS AND APPARATUS FOR DELIVERING AEROSOLIZED MEDICATION

Номер: US20160067429A1
Автор: Kakade Prashant
Принадлежит:

A pulmonary drug delivery device having one or more vortexing elements which impart beneficial flow characteristics to an inspiratory air flow carrying a medicament into the patient's lungs. 1. An aerosol flow control apparatus for use in a pressurized metered dose inhaler , said apparatus comprising:(a) a housing defining a conduit, said conduit having an open end that provides a mouthpiece, a substantially closed end, and a vortexing back plate positioned remotely from the open end and defining the substantially closed end; said vortexing back plate comprising a first set of vortexing air inlets in fluid communication with ambient air outside the conduit;wherein said vortexing back plate is disposed in the conduit such that the first set of vortexing air inlets opens into a direction towards the mouthpiece; andwherein said first set of vortexing air inlets is angled so as to impart a vortexing motion to the ambient air drawn into the conduit through the first set of vortexing air inlets; and(b) a pressurized canister comprising a medicament, said pressurized canister arranged within the housing to direct a bolus of the medicament into the conduit.2. The aerosol flow apparatus of claim 1 , further comprising a second set of vortexing air inlets disposed about the periphery of the vortexing back plate.3. The aerosol flow apparatus of or claim 1 , wherein the vortexing air inlets comprise inwardly directed vanes which are oriented at an angle.4. The aerosol flow apparatus of claim 2 , wherein the second set of vortexing air inlets are triangular in shape so as to impart a further vortexing motion to the air drawn into the conduit through the first set of vortexing air inlets.5. The aerosol flow apparatus of claim 1 , wherein the votexing back plate is located behind the position at which the medicament bolus is introduced into an inspiratory air flow.6. The aerosol flow apparatus of or claim 1 , wherein the vortexing air inlets impart a tangential velocity to an ...

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Номер записи: 93
27-02-2020 дата публикации

SMART INHALER DEVICE WITH AUTOMATED DOSE DELIVERY, MEASUREMENT, AND MANAGEMENT

Номер: US20200061314A1
Автор: Edalat Paul, Hatamian Mehdi
Принадлежит:

A smart inhaler device includes: a flow pathway comprising a cartridge receptacle that is able to house a cartridge, flow meter, pump, and vaporizer; a wireless communication module; and at least one sensor that captures identifying information related to the cartridge. A method of providing a measured dose using a smart inhaler device includes: enabling dosing; measuring a provided dose; and disabling dosing. A smart inhaler system includes: a smart inhaler device; a user device; and a server. 1. A smart inhaler device comprising:a flow pathway comprising a cartridge receptacle that is able to house a cartridge, flow meter, pump, and vaporizer;a wireless communication module; andat least one sensor that captures identifying information related to the cartridge.2. The smart inhaler device of claim 1 , wherein the flow pathway further comprises an output blower that assists a vaporized substance along the flow pathway from the vaporizer to a mouth piece.3. The smart inhaler device of further comprising a storage that collects usage information related to the smart inhaler device.4. The smart inhaler device of claim 3 , wherein the usage information comprises at least one of a quantity measured by the flow meter claim 3 , identifying information related to the cartridge claim 3 , a number of doses administered claim 3 , and a timestamp associated with each administered dose.5. The smart inhaler device of claim 1 , wherein the at least one sensor comprises a camera and the identifying information comprises a graphic code.6. The smart inhaler device of claim 1 , wherein the at least one sensor comprises a near field communication (NFC) receiver and the identifying information comprises an NFC tag.7. The smart inhaler device of claim 1 , wherein the cartridge comprises a substance associated with a prescription claim 1 , the prescription comprising at least one of a specified dose amount claim 1 , dose frequency claim 1 , maximum dose claim 1 , maximum dose over time ...

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Номер записи: 94
19-03-2015 дата публикации

APPARATUS FOR THE AEROSOLIZATION OF LARGE VOLUMES OF DRY POWDER

Номер: US20150075527A1
Автор: Iwatschenko Peter, Kist Michel, Koch Wolfgang, Pohlmann Gerhard, Windt Horst
Принадлежит:

The invention relates to a device for dosing and aerosolization of aerosolizable material. The device comprises a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses. 119.-. (canceled)20. A system for dosing and aerosolization of aerosolizable material , the system comprising:a body with an aerosolization channel having a distal attachment portion connectable to a source of carrier gas which provides pressure pulses of the gas to the aerosolization channel and a proximal attachment portion for outputting aerosolized material towards a patient;a reservoir for receiving aerosolizable material, the reservoir comprising at least one wall and being connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel;an additional piece of pathway for aerosol to traverse configured to introduce expansion space for the pulsed gas stream and thus allow the pressure pulse of the gas arranged to carry the aerosol to the patient to dampen, the additional piece of pathway being a first hollow spacer comprising a distal portion having at least one inner wall tapered towards the proximal attachment portion, and a proximal portion having at least one inner wall and configured to taper towards the patient, and the additional piece of pathway further being connected to the proximal attachment portion; anda compensation tubing provided between an interior of the first hollow spacer and an interior of the reservoir,wherein the at least one inner wall of the ...

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Номер записи: 95
17-03-2016 дата публикации

Methods and Devices for Co-Delivery of Liquid and Powdered Hemostats and Sealants

Номер: US20160074602A1
Автор: Kriksunov Leo B., Wang Yi-Lan
Принадлежит:

The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices. 1. An integrated delivery device operable with one hand and for co-delivery of a liquid medicant and a powder medicant onto a tissue or wound comprising at least two integrated medicant expression subunits ofa) a liquid medicant expression subunit and a a. each expression subunit having an actuator for the medicant contained therein, the actuators are positioned in close proximity to each other at a proximate end of said expression subunits, and', 'b. delivery cannulas for each of said expression subunits that positioned in close proximity to each other at a distal end of said expression subunits., 'b) a powder medicant expression subunit,'}2. The integrated delivery device of claim 1 , wherein the liquid medicant expression subunit comprises a syringe containing the liquid medicant claim 1 , and the powder medicant expression subunit comprises a powder delivery pump.3. The integrated delivery device of claim 2 , wherein the liquid medicant comprises a two-part sealant or hemostat claim 2 , and the syringe comprises a dual barrel syringe with each barrel containing one of different individual components of the two-part sealant or hemostat.4. The integrated delivery device of claim 3 , wherein the powder delivery pump comprises a resiliently compressible bellows and a ...

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Номер записи: 96
15-03-2018 дата публикации

Pre-Filled, Small-Volume Nebulizer and Method of Manufacture

Номер: US20180071464A1
Автор: Faram Joseph Dee
Принадлежит: Caddo Medical Technologies LLC

The invention relates to a small-volume nebulizer that is pre-filled with at least one unit-dose of medicine and hermetically sealed until use. The nebulizer may be sealed at the top with a removable cap that may be detached at the time of use and replaced with a patient connector. Likewise, the nebulizer may be sealed at the bottom with a bottom cap that is replaced with a gas source at the beginning of a therapeutic aerosol treatment. 1. A sterilized , pre-filled , small-volume nebulizer ready for a patient to administer for respiratory care comprising:a small-volume nebulizer body comprising a housing top having an outlet opening and a baffle and a housing bottom having an inlet opening;a siphon and jet component contained within said small-volume nebulizer body between said inlet opening and said baffle;a first cap sealing said outlet opening;a second cap sealing said inlet opening;a unit-dose of medication contained within said small-volume nebulizer body, wherein said small-volume nebulizer body and said siphon and jet component were sterilized; andwherein said first cap and said second cap prevent said unit-dose of medication from spilling from said small-volume nebulizer body.2. The sterilized claim 1 , pre-filled claim 1 , small-volume nebulizer according to claim 1 , further comprising a means for preventing egress of said unit-dose of medication through said inlet opening.3. The sterilized claim 1 , pre-filled claim 1 , small-volume nebulizer according to claim 1 , further comprising a means of preventing retrograde movement into said nebulizer housing.4. The sterilized claim 1 , pre-filled claim 1 , small-volume nebulizer according to claim 1 , further comprising a plurality of said unit-doses of medication.5. The sterilized claim 4 , pre-filled claim 4 , small-volume nebulizer according to claim 4 , further comprising unit-dose completion demarcation marks.6. The sterilized claim 1 , pre-filled claim 1 , small-volume nebulizer according to claim 1 , ...

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Номер записи: 97
16-03-2017 дата публикации

Dry Powder Delivery System and Method

Номер: US20170071505A1
Автор: Han Steve, Stenzler Alex
Принадлежит:

A dry powder inhalation device includes in certain embodiments a spin chamber and a cartridge for holding multiple capsules. The capsules contain a dry powder that in certain embodiments includes methacholine. In certain embodiments, an adjustable limiting mechanism is configured to limit inhaled volume through the second passageway. In certain embodiments, the cartridge moves linearly or radially though a portion of the device. In certain embodiments, capsules in the cartridge align with a port in the spin chamber to load into the spin chamber. User inhalation on a mouthpiece of the device generates a vortical airflow and causes the capsules to spin within the chamber, releasing a portion of the dry powder for inhalation. In certain embodiments, the device is used for an inhalation diagnostic challenge. The inhalation diagnostic challenge can be automated, using a graphical user interface, an imaging system, user feedback mechanisms, and electromechanical components within the device for automating device operation. 1. A dry powder delivery device comprising:a mouthpiece comprising a proximal and distal opening with a first passageway extending therebetween;a spin chamber comprising a port and an ejection door, wherein the spin chamber is connected to the first air passageway;a housing comprising a second passageway, wherein the second passageway is connected to the first passageway and further comprises an airflow sensor;a controller operably connected to the airflow sensor; anda cartridge comprising a plurality of dry powder receptacles that are configured to align with the port as the cartridge moves relative to the housing.2. The dry powder delivery device of claim 1 , wherein the second passageway comprises an adjustable limiting mechanism configured to limit inhaled volume through the second passageway.3. The dry powder delivery device of claim 2 , wherein the adjustable limiting mechanism is configured to limit inhaled volume through the second passageway to ...

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Номер записи: 98
24-03-2022 дата публикации

INHALATION DEVICE INCLUDING SUBSTANCE USAGE CONTROLS

Номер: US20220088321A1
Автор: Alelov Eli
Принадлежит: Logic Technology Development, LLC

An apparatus including a first cartridge, a sensor, and a controller. The first cartridge can include a first release device configured to release a first substance into a housing. The controller can be configured to receive data from the sensor. The controller can determine an amount of first substance released by the first cartridge based on the data. The first release device can be controlled based on the determined amount of first substance. 1. (canceled)2. An inhalation device configured to control operation of a release device configured to release a substance contained in a cartridge , the inhalation device comprising:a controller configured to control operation of the release device; anda timer configured to measure duration of airflow through the inhalation device for each puff;wherein the controller is configured to turn off the release device when the measured duration of airflow reaches or exceeds a limit value.3. The inhalation device according to claim 2 , further comprising a sensor configured to detect one or more of an airflow claim 2 , a temperature change claim 2 , a pressure change claim 2 , illumination of light claim 2 , a current change claim 2 , and a voltage change.4. The inhalation device according to claim 3 , wherein the sensor is an airflow sensor claim 3 , a thermocouple claim 3 , a pressure sensor claim 3 , a shock sensor claim 3 , a sound sensor claim 3 , or a microphone.5. The inhalation device according to claim 3 , wherein the timer is configured to be activated by the sensor.6. The inhalation device according to claim 3 , wherein the timer measures a puff duration while the sensor is activated.7. The inhalation device according to claim 2 , wherein the limit value is set as a total time allowed for airflow through the inhalation device within a given period of use.8. The inhalation device according to claim 2 , further comprising a cartridge that contains a substance configured to be released by the release device.9. The ...

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Номер записи: 99
05-03-2020 дата публикации

LIQUID STORAGE ASSEMBLY, ATOMIZER AND ELECTRONIC CIGARETTE HAVING THE SAME

Номер: US20200069894A1
Автор: QIU Weihua
Принадлежит:

A liquid storage assembly includes a liquid storage tube having a liquid storage chamber, a sealing member, an adjusting member, and a lower cover. The sealing member is received in the liquid storage tube and defines a second liquid intake hole fluidly communicating with the liquid storage chamber. The adjusting member is received in the liquid storage tube and is rotatable relative to the sealing member, the adjusting defines a communicating portion corresponding to the second liquid intake hole. 1. A liquid storage assembly , comprising:a liquid storage tube having a liquid storage chamber;a sealing member received in the liquid storage tube and defining a second liquid intake hole fluidly communicating with the liquid storage chamber;an adjusting member received in the liquid storage tube and rotatable relative to the sealing member, the adjusting defining a communicating portion corresponding to the second liquid intake hole; anda lower cover positioned on an end of the liquid storage tube;wherein the lower cover or the sealing member is provided with a blocking portion, the adjusting member is provided with an resisting portion capable of resisting the blocking portion, when the liquid storage assembly is disassembled, the adjusting member is rotated to enable the resisting portion to reach and resist the blocking portion, causing the adjusting member to seal the second liquid storage chamber to close the liquid storage chamber.2. The liquid storage assembly according to claim 1 , wherein an internal wall of the lower cover is provided with a restriction portion claim 1 , a number of the blocking portion is two claim 1 , the two blocking members are opposite to each other and are protruded from the restricting portion claim 1 , the resisting portion is capable of resisting the restricting portion along an axial direction and resisting the blocking portion along a circumferential direction.3. The liquid storage assembly according to claim 2 , wherein the liquid ...

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Номер записи: 100