БЕСПЛАМЕННАЯ ЭЛЕКТРОННАЯ СИГАРЕТА С РАСПЫЛЕНИЕМ

Изобретение относится к беспламенной электронной сигарете с распылением, не содержащей вредной смолы, а только алкалоид табака (никотин). Сигарета представляет собой единую конструкцию с формой в виде мундштука сигареты, включающая оболочку, батарею, высокочастотный генератор, запасающий раствор, содержащий алкалоид табака, и его контейнер, схему управления, экран дисплея, датчик потока воздуха, датчик контакта, пьезоэлектрический ультразвуковой распылитель, струйную трубку для высокотемпературной газификации и другие принадлежности. Струйную трубку для электротепловой газификации, установленную внутри оболочки в концевой части, предназначенной для втягивания воздуха, присоединяют к высокочастотному генератору на панели схемы управления через электрически управляемый насос или клапан, имеющий измерительную камеру и капсулу для хранения жидкости с одноходовым наполнительным клапаном для раствора алкалоида табака, присоединенным к электрически управляемому насосу или клапану. Четыре выходных ...

СПОСОБ УПРАВЛЯЕМОГО ПАЦИЕНТОМ ВВЕДЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ В АЭРОЗОЛЬНОЙ ФОРМЕ

Группа изобретений включает способ управления введением медицинского препарата (варианты), вентиляционную систему для использования пациентом, машиночитаемый носитель записи и контроллер вентилятора, относится к области медицинской техники и предназначена для управления со стороны пациента введением лекарственных средств в аэрозольной форме с использованием вентилятора. Первый вариант способ управления введением медицинского препарата содержащий этапы, на которых: конфигурируют генератор аэрозолей для аэрозольного распыления медицинского препарата и введения распыленного медицинского препарата пациенту с использованием вентилятора, содержащего первый процессор; предоставляют пациенту пациентский интерфейс управления; конфигурируют второй процессор для управления вентилятором и генератором аэрозолей в ответ на команды от пациентского интерфейса управления. Пациентский интерфейс управления, выполнен с возможностью посылать сигналы второму процессору, посредством которого пациент инициирует ...

СИСТЕМЫ ДОСТАВКИ АЭРОЗОЛЯ И СООТВЕТСТВУЮЩИЕ СПОСОБЫ

Изобретение относится к медицинской технике, а именно к блоку (10, 210, 410) доставки аэрозоля для селективной доставки дозы аэрозолированного вещества. Блок содержит основной корпус (12, 212, 412) и узел (260) исполнительного механизма, имеющийся в основном корпусе (12, 212, 412). Блок включает узел (14, 214, 414) съемного картриджа, соединенный с основным корпусом (12, 212, 412) и взаимодействующий с узлом (260) исполнительного механизма. Узел (14, 214, 414) съемного картриджа включает в себя контейнер (16, 216, 416), содержащий вещество, подлежащее аэрозолизации; и блок картриджа, в который загружается контейнер (16, 216, 416). Блок картриджа включает в себя тело (90, 290, 430) картриджа, имеющее отверстие (92, 292, 432) мундштука, через которое осуществляется вдыхание дозы аэрозолированного вещества, высвобождаемого из контейнера (16, 216, 416), по меньшей мере одно впускное отверстие (94, 294, 436), через которое может поступать воздух в блок картриджа, и ингаляционный проход (96, ...

РАСПОЗНАВАНИЕ ПРИБЛИЖЕНИЯ ДЛЯ УСТРОЙСТВА ДОСТАВКИ АЭРОЗОЛЯ

Изобретение относится к управляющему корпусу, который соединен или выполнен с возможностью соединения с картриджем, который оснащен нагревательным элементом и содержит композицию предшественника аэрозоля, причем управляющий корпус соединен или выполнен с возможностью соединения с картриджем с образованием устройства для доставки аэрозоля, в котором нагревательный элемент выполнен с возможностью активирования и испарения компонентов композиции предшественника аэрозоля, при этом управляющий корпус содержит: оболочку и внутри оболочки датчик потока, выполненный с возможностью обнаружения потока воздуха по меньшей мере через часть оболочки и вывода сигнала обнаружения воздушного потока в ответ на таким образом обнаруженный поток воздуха; управляющий компонент, выполненный с возможностью работы в активном режиме, в котором управляющий корпус соединен с картриджем, при этом управляющий компонент в активном режиме выполнен с возможностью управления нагревательным элементом для активирования и ...

ДОЗАТОР ЛЕКАРСТВЕННЫХ СРЕДСТВ С ДИСПЛЕЕМ ДЛЯ ОТОБРАЖЕНИЯ ИНДИКАЦИОННЫХ ДАННЫХ ДЛЯ ПОЛЬЗОВАТЕЛЯ

Изобретение относится к медицине. Дозатор содержит выпускное отверстие для выдачи лекарственного средства, дисплей для отображения индикационных данных для пользователя, крышку выпускного отверстия, выполненную с возможностью перемещения между первым положением, в котором она закрывает выпускное отверстие, и вторым положением, в котором выпускное отверстие открыто. При нахождении крышки выпускного отверстия в первом положении индикационные данные на дисплее открыты для обзора. При нахождении указанной крышки во втором положении индикационные данные скрыты от пользователя. Технический результат состоит в обеспечении средств для побуждения пользователя к закрытию выпускного отверстия за счет отображения информации только при закрытом отверстии дозатора. 15 з.п. ф-лы, 3 ил.

БЕСПЛАМЕННАЯ ЭЛЕКТРОННАЯ СИГАРЕТА С РАСПЫЛЕНИЕМ

... 1. Беспламенная электронная сигарета с распылением, отличающаяся тем, что сигарета состоит из единой конструкции с формой в виде мундштука сигареты, включающей оболочку, батарею, высокочастотный генератор, запасающий раствор, содержащий алкалоид табака, и его контейнер, схему управления, экран дисплея, датчик потока воздуха, датчик контакта с телом человеком, пьезоэлектрический ультразвуковой распылитель, струйную трубку для высокотемпературной газификации и другие принадлежности, при этом струйную трубку для электротепловой газификации (17), установленную внутри оболочки в концевой части, предназначенной для втягивания воздуха (6), присоединяют к высокочастотному генератору на панели схемы управления (8) через электрически управляемый насос (11) или клапан, имеющий измерительную камеру и капсулу для хранения жидкости (13) с одноходовым наполнительным клапаном (12) для раствора алкалоида табака, присоединенным к электрически управляемому насосу или клапану, и ультразвуковому пьезоиду (20 ...

ПОЛЬЗОВАТЕЛЬСКИЙ ИНТЕРФЕЙС

... 1. Интерфейсное устройство для обеспечения надлежащего дозирования, а также безопасной работы ингалятора для сухого порошка (ИСП), предназначенного для введения порошка для ингаляции, и управления этим ингалятором, отличающееся тем, что оно содержит средство загрузки в ингалятор для сухого порошка кассеты (4), вмещающей предварительно отмеренные дозы, для подготовки нескольких последовательных введений порошковых доз в легкие пользователя, средство предохранения пользователя от загрузки кассеты, не содержащей должного порошка, которое содержит индивидуальное кодовое приспособление для дозовой кассеты, средство информирования пользователя о необходимости замены присутствующего мундштука (19) на новый после его использования в заданном количестве ингаляционных процедур для обеспечения высокого уровня гигиены и устранения возможного скопления остающегося порошка. 2. Интерфейсное устройство по п.1, отличающееся тем, что оно дополнительно содержит средство (18b, 18с) информирования пользователя ...

АЭРОЗОЛЬНЫЙ АСПИРАТОР И СПОСОБ ВСАСЫВАНИЯ АЭРОЗОЛЯ

... 1. Аэрозольный аспиратор, включающий ! корпус с мундштуком, включающий впускное отверстие для наружного воздуха, открытое на его наружной поверхности, ! генерирующее устройство, размещенное внутри корпуса, для формирования аэрозоля, при этом генерирующее устройство включает ! канал формирования аэрозоля, проходящий от впускного отверстия для наружного воздуха до мундштука и имеющий место распределения и распылительную поверхность в своей средней части, !питающий насос, имеющий растворную камеру, содержащую раствор, преобразуемый в аэрозоль, для подачи раствора из растворной камеры в место распределения в фиксированном количестве каждый раз, когда приводится в действие питающий насос, и ! распылительное приспособление для распыления раствора, подведенного в место распределения у распылительной поверхности. ! 2. Аэрозольный аспиратор по п.1, в котором канал формирования аэрозоля представляет собой трубчатый канал. ! 3. Аэрозольный аспиратор по п.2, в котором распылительное приспособление ...

СИСТЕМА И СПОСОБ КОНТРОЛИРУЕМОГО МЕДИКАМЕНТОЗНОГО ЛЕЧЕНИЯ

ИНТЕРАКТИВНОЕ УСТРОЙСТВО И СПОСОБ ПРОФИЛИРОВАНИЯ УСИЛИЙ ПРИ ИНГАЛЯЦИИ В РЕАЛЬНОМ МАСШТАБЕ ВРЕМЕНИ

... 1. Система для ингаляции сухого порошка, содержащая:сухопорошковый ингалятор;картридж, выполненный с возможностью использования с упомянутым сухопорошковым ингалятором; идатчик, сообщающийся с упомянутым сухопорошковым ингалятором, при этом упомянутый датчик детектирует по меньшей мере один сигнал, генерируемый упомянутым сухопорошковым ингалятором, и передает упомянутый по меньшей мере один сигнал по меньшей мере на один блок для анализа, хранения, распечатывания или отображения.2. Система для ингаляции сухого порошка по п.1, в которой упомянутый датчик скомпонован в упомянутом сухопорошковом ингаляторе или адаптирован к упомянутому сухопорошковому ингалятору.3. Система для ингаляции сухого порошка по п.1, в которой упомянутый сигнал представляет собой звуковой сигнал.4. Система для ингаляции сухого порошка по п.3, в которой звуковой сигнал представляет собой амплитуду звукового сигнала, частоту звукового сигнала или их комбинацию.5. Система для ингаляции сухого порошка по п.1, в которой ...

СИСТЕМА РАЗДЕЛЬНОЙ ПОДАЧИ ПОТОКА ВОЗДУХА ДЛЯ ЭЛЕКТРИЧЕСКИ НАГРЕВАЕМОЙ КУРИТЕЛЬНОЙ СИСТЕМЫ И СПОСОБ НАПРАВЛЕНИЯ ПОТОКА ВОЗДУХА ВНУТРИ ЭЛЕКТРИЧЕСКИ НАГРЕВАЕМОЙ КУРИТЕЛЬНОЙ СИСТЕМЫ

ИНГАЛЯЦИОННОЕ УСТРОЙСТВО ДЛЯ МЕДИКАМЕНТОВ В ПОРОШКОВОЙ ФОРМЕ

... 1. Ингаляционное устройство (1) для порошковых лекарственных препаратов, содержащее, по меньшей мере, одну камеру (13) для размещения и хранения множества доз порошка лекарственного препарата; и дозирующее устройство, включающее в себя, по меньшей мере, один сдвижной дозатор (15), выполненный с возможностью, по существу, поступательного перемещения в канале (16) сдвижного дозатора, по меньшей мере, из положения заполнения в положение опорожнения, при этом ингаляционное устройство (1) дополнительно содержит устройство для активируемого вдохом автоматического перемещения сдвижного дозатора (15) из положения заполнения в положение опорожнения; и устройство возврата для автоматического перемещения сдвижного дозатора (15) обратно в положение заполнения. ! 2. Ингаляционное устройство по п.1, отличающееся тем, что канал (16) сдвижного дозатора, по меньшей мере, вместе с одним сдвижным дозатором (15) и указанной камерой (13) герметично закрыты по отношению к окружающей среде, по меньшей мере, в ...

INHALATOR FÜR PULVERARTIGES MEDIKAMENT

WIRKSTOFFABGABEVORRICHTUNG

INHALATOR

Dose dispensing apparatus

Inhalation device

A counting device for dispenser

A dispenser e.g. inhaler, comprises a cannister 200 for containing a substance, the canister 200 having a delivery portion at one end which includes delivery portion at one end which includes delivery means through which a dose is deliverable, and a protruding portion at an end opposite the delivery portion which protrudes from the housing. An electrical counting device 100 attached to the protruding portion, the counting device 100 including display means 7 and a switch 3, wherein the switch 3 is actuatable by interaction with the housing during relative movement between the cannister 200 and the housing.

Devices, systems and methods for medicament delivery

An apparatus includes a housing, a medicament container and an actuator. The apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

Metered dose dispensers and assemblies therefor

Metered dose inhaler with vortex device

The present invention relates to metered dose inhalers for the administration of active medicaments/propellants and excipients. The invention provides a pMDI inhaler comprising a pMDI canister 22, a vortex device, an integral horn and a breath-activated mechanism 26, 28, 34 wherein the canister contains a formulation comprising a combination of two or more active ingredients. Proposed active ingredients include beta agonists, inhaled corticosteroids and anticholinergics. The integral horn may have a shape which widens towards the mouthpiece, thus reducing the aerosol flow velocity.

Devices, systems and methods for medicament delivery

Inhaler

A counter with motion sensor

A counter assembly 1 that uses a motion sensor 40, 41 to detect movement and display a drug status for a device such as an inhaler. The counter assembly 1 can count the number of times a displacement occurs between a canister 4 containing a drug and the housing body 2. The counter includes a pcb 7, switch 5, display indicator 26. The counter 1 is friction mounted onto the canister 4. In another embodiment the counter mechanically counts displacement between the canister and the housing and displays a count value on mechanically rotating wheels 32.

Medicament dispenser

Improvements in or relating to dispensing apparatus - and dose counters

A electrical isolation member for an electronic auto-injector

An auto-injector 4002 is first enabled by removing the needle guard 4810 and the safety lock 4710. As illustrated by arrow AA in FIG. 57, the needle guard 4810 is removed by moving it distally. The sheath retainer 4840 includes an actuator 4864 that is received by an opening 4862 in the isolation tab 4860. Accordingly, when the sheath retainer 4840 is moved distally away from the base 4520, the isolation tab 4860 is removed from the area between the first electrical contact portion 4936 of the printed circuit board 4922 and the first surface 4964 of one of the batteries 4962. In this manner, the batteries 4962 can be operatively coupled to the electronic circuit system 4920 when the needle guard 4810 is removed, thereby actuating the electronic circuit system 4920.

Actuator for an inhaler having a lip sensor

The actuator has a main container with clips A to accommodate a pDMI inhaler and a lip trigger B on a mouthpiece. In use the sensor, which may be a capacitance switch, initiates a timer circuit to delay the activation of internal mechanical actuators (fig 5) which in turn activate the pressurized canister in the pDMI inhaler. The circuitry and mechanical actuators are all located in the main container. The actuator may further comprise a mouthpiece protector which covers the lip trigger when not in use.

Identification of risk of myocardial infarction

Stand-alone dose counter

Casing and spirometer for metered dose inhaler

Dispenser with doses counter.

There is provided a dispenser suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The dispenser comprises a housing (1) having a support (5); a container (2), locatable within said housing (1), having an outer member, wherein said container (2) is ovable relative to the housing (1) to en-able dispensing therefrom and said outlet member is connectable with said support (5) to prevent relative movement therebetween; and a dose indicator (13, 43), locatable within said housing (1). The container (2) and dose indicator (1 3, 43) are reversably removable from the housing (1) as a single unit.

Dispenser with doses counter

Dispenser with doses counter

DELIVERY DEVICE FOR NEBELFÖRMIGE MEDICINES

SYSTEM FOR SUPERVISING PATIENT DATA

AEROSOL GENERATOR AND PROCEDURE FOR THE PRODUCTION OF AN AEROSOL GENERATOR

MEDICAL INHALATION APPARATUS

MEDICINE DONOR

DOSE COUNTER

MINIATURIZED DEVICES TO THE DELIVERY OF MOLEKULEN IN ONE TRAGERFLUSSIGKEIT

ACTIVE SUBSTANCE DELIVERY DEVICE

ACOUSTIC ONE INHALATOR FLUSSMESSUNG

INHALATION DEVICE F�R DRUG IN POWDER FORM

DOSING SYSTEM AND PROCEDURE FOR THE AEROSOL RELEASE

AEROSOL PROCESSING ROUTE AND SYSTEM FOR THE DELIVERY OF A DRUG IN AEROSOL FORM WITH HIGH DOSE

PROCEDURE AND DEVICE FOR DELIVERING MEDICINES IN AEROSOLFORM

DOSING DONOR

DELIVERY DEVICE FOR DRUGS AND PROCEDURE FOR THE DELIVERY OF DRUGS

DONOR FOR MEDICINE

DONOR WITH COUNTING DEVICE OF THE DOSE UNITS

INHALATOR

DELIVERY DEVICE F�R DRUG

DONOR FOR MEDICINES

IMPROVEMENTS WHEN ARZNEIMITTELFÖRDENDEN DEVICES AND THEIR CONTROL

DONOR

DEVICE TO THE PROPORTIONED ONE INHALIERUNG

AEROSOL CONTAINER AND DONOR WITH METERING UNIT COUNTER

Apparatus for controlled delivery of opioid and other medications

A method, system and apparatus for administering various medicaments including those for treating pain and substance dependency are disclosed. The apparatus is a unit for heat activation of a morphine opiate liquid concentrate mixed with a carrier substance to produce inhaled gas. The method includes inhaling the heat activated gaseous vapor concentrate for pain relief, to treat substance dependency or administration of other medicaments. The system includes a heat vaporization unit with security, control and communication capability to provide effective patient care and ensure safety.

Drug delivery device with electronics

A device (100) for delivering medication to a user may include a main body (104), an electronics module (102), and a slider. The main body may include a mouthpiece (106), a medication reservoir, and a mouthpiece cover (108), where the mouthpiece cover may be hinged to the main body. The electronics module may include a communication circuit, a pressure sensor, and a switch. The slider may be configured to engage the switch when the mouthpiece cover moves from a closed position to an open position. The switch may be configured to switch the electronics module from an off state or a sleep state to an active state. The electronics module may be configured to never return to the off state after the mouthpiece cover is moved to expose the mouthpiece for the first time by the user.

PROPELLANT BASED METERED DOSE INHALER AND FOOD APPLICATORS AND APPLICATORS

H:\nte rwoven\NRPortbl\DCC\LJR898693_1.doc-5/6/2019 Provided herein are embodiments related to metered dose inhalers and/or food applicators and/or applicators. Fig. 6B A 50° A Section A-A ...

A medication cassette for an automatic aerosol medication delivery system

User interface

Apparatus, system and method for detection and delivery of a medicinal dose

An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined ...

Inhaler

An inhaler

Drug products and dry powder inhalers with multiple reservoirs

Various embodiments of the present invention provide drug products and dry powder inhalers and powder dispensers with multiple reservoirs. Several embodiments provide a drug product comprising a dry powder inhaler and at least one dose of at least one active pharmaceutical agent; wherein the dry powder inhaler comprises at least two reservoirs. Other embodiments provide for a powder dispenser which includes a first powder reservoir having at least one first opening, and a second powder reservoir having at least one second outlet opening, the second outlet opening being spaced from the first outlet opening.

Medicament dispenser

Counters for fluid dispensers

ALERTING SYSTEM

Medicament dispenser

MEDICAMENT DISPENSER

Method and system for determining information related to a drug reservoir

A method (900, 1000) and system (100, 700) for detecting information related to a drug reservoir (400, 800). The method (900, 1000) includes transmitting energy (103) at a coded material (120) disposed on a drug reservoir (400, 800), where the energy (103) has at least one predefined characteristic. The coded material (120) identifies information related to the drug reservoir (400, 800). The coded material (120) modifies the energy (103) and emits the modified energy (105) to a receiver (107, 707). The method (900, 1000) further includes receiving at the receiver (107, 707) the modified energy (105). The method (900, 1000) further includes determining information related to the drug reservoir (400, 800) based on the modified energy (105) as the drug reservoir (400, 800) is loaded into a drug delivery device (600, 1100).

Device for administering insulin in controlled dosages by controlling total inhaled volume

Medicament dispenser

Electronic monitoring medication apparatus and method

Dynamic particle size control for aerosolized drug delivery

A nasal inhaler

Medicament dispenser

MEDICAMENT DISPENSER

There is provided a medicament dispenser for use in the storage, presentation and/or dispensing of medicament comprising a body shaped for receipt of a medicament container. In association with the body, there is a first transceiver for transmitting and receiving data. A medicament container is receivable by the body. In association with the medicament container, there is a second transceiver for transmitting and receiving data. Data is transferable in two-way fashion from the first transceiver to the second transceiver. The medicament dispenser may be supplied in kit of parts form.

AEROSOL GENERATOR AND METHODS OF MAKING AND USING AN AEROSOL GENERATOR

An aerosol generator (21) includes a flow passage (27) having an inlet (29), and an outlet (31); a heater (33) arranged relative to the flow passage for heating the flow passage, a source of material (37) to be volatilized in communication with the inlet of the flow passage; a valve (35) to open, and close communication between the source of material; the inlet of the flow passage; and a pressurization arrangement (39) for causing material in the source of material to be introduced into the flow passage when the valve is in an open position. The aerosol generator further includes a source of power (41) for operating the heater, the valve; and a control device (43) for controlling supply of power from the source of power to the heater, and the valve. A metering device (463) in an inhaler (401) includes a pressurized source of medicated fluid (408), and a metering chamber (407) configured to deliver a predetermined volume of fluid to a heated flow passage (409) in the inhaler.

MULTIPLE DOSE CONDENSATION AEROSOL DEVICES AND METHODS OF FORMING CONDENSATION AEROSOLS

A DRUG DELIVERY AND MONITORING SYSTEM FOR A VENTILATOR

An automated drug delivery and monitoring system for use on mechanically ventilated patients in the intensive care unit is presented. Medication in the form of respirable particles is transported through ventilator circuitry by a delivery unit. Multiple medications may be delivered into the gas flow of the ventilator, with each medication delivered in a defined dose for a frequency and interval as specified by an operator. The particles mixed into the gas flow of the ventilator are inhaled and ingested by the patent's lungs.

A DRUG DELIVERY AND MONITORING SYSTEM FOR A VENTILATOR

An automated drug delivery and monitoring system for use on mechanically ventilated patients in the intensive care unit is presented. Medication in the form of respirable particles is transported through ventilator circuitry by a delivery unit. Multiple medications may be delivered into the gas flow of the ventilator, with each medication delivered in a defined dose for a frequency and interval as specified by an operator. The particles mixed into the gas flow of the ventilator are inhaled and ingested by the patent's lungs.

DRUG PRODUCTS AND DRY POWDER INHALERS WITH MULTIPLE RESERVOIRS

Various embodiments of the present invention provide drug products and dry powder inhalers and powder dispensers with multiple reservoirs. Several embodiments provide a drug product comprising a dry powder inhaler and at least one dose of at least one active pharmaceutical agent; wherein the dry powder inhaler comprises at least two reservoirs. Other embodiments provide for a powder dispenser which includes a first powder reservoir having at least one first opening, and a second powder reservoir having at least one second outlet opening, the second outlet opening being spaced from the first outlet opening.

APPARATUS FOR ELECTRONIC DOSAGE COUNTER

An apparatus for dispensing medication having a canister containing medication to be dispensed to a user. The canister is movable in both a first and a second direction. The apparatus also includes a mouthpiece that provides a point of egress for the medication. The medication is dispensed to the user when the canister is moved in the first direction. Also included in the apparatus is a switch for completing an electrical circuit. The switch is activated when the canister is moved in the first direction closing the electrical circuit. The electrical circuit is opened when the canister moves in the second direction. A counter module is disclosed for performing a count upon the closure of the electrical circuit. The counter module also displays a dispensation history of the medication in the canister. The apparatus also includes a seal for isolating the counter module from the mouthpiece and the canister.

USER INTERFACE

An interface arrangement is disclosed for ensuring proper dosing as well as achieving a safe operation and handling of a dry powder inhaler (DPI) used for administration of a powder to be inhaled. The interface of the present invention primarily handles the loading of a cassette (4) carrying pre-metered doses into the dry powder inhaler (8). An important characteristic is that the interface by utilizing a particular coding prevents a user from loading a cassette not containing the proper powder. Additionally the interface informs a user when a new mouthpiece has to be replaced after being used for a pre- defined number of inhalation operations. Additionally the interface informs a user when a present cassette has delivered its last dose and should be exchanged. Also information on the number of further cassettes already utilized will control that another cassette still is permitted to be loaded. If this counter exceeds a pre-defined number of used cassettes the inhaler then is be definition ...

MEDICAMENT DISPENSER

There is provided a medicament dispenser for dispensing medicament comprising: a body; a holder, shaped to fit within the body and movable relative to the body; and receivable by said holder, a cassette containing a medicament carrier, wherein movement of the holder relative to the body results in movement of the cassette between a first position and a second position such that the cassette is reversibly removable from the holder when the cassette is in the second position.

OPTICAL DRY POWDER INHALER DOSE SENSOR

A dry powder inhaler including a first chamber having an orifice for holding a dry powder and a gas, and a second chamber connected to the first chamber by at least one passageway for receiving an aerosolized form of the dry powder from the first chamber and delivering the aerosolized dry powder to a user. At least one optical sensor monitors aerosolized powder particles passing in the second chamber. A vibrator coupled to the first chamber aerosolizes the dry powder and causes the aerosolized powder to move through the at least one passageway thereby delivering the powder from the first chamber to the second chamber as an aerosolized dry powder. A vibrator control unit controls operation of the vibrator based on the amount of aerosolized powder particles passing in the second chamber and delivered to a user.

DRUG DELIVERY DEVICE WITH ELECTRONICS

A device (100) for delivering medication to a user may include a main body (104), an electronics module (102), and a slider. The main body may include a mouthpiece (106), a medication reservoir, and a mouthpiece cover (108), where the mouthpiece cover may be hinged to the main body. The electronics module may include a communication circuit, a pressure sensor, and a switch. The slider may be configured to engage the switch when the mouthpiece cover moves from a closed position to an open position. The switch may be configured to switch the electronics module from an off state or a sleep state to an active state. The electronics module may be configured to never return to the off state after the mouthpiece cover is moved to expose the mouthpiece for the first time by the user.

MEDICAL EVALUATION DEVICE

The present invention relates to a medical evaluation device (10) for evaluating an adherence to a therapy protocol when using an aerosol nebulizer (30) having an aerosol generator (31) for nebulizing a liquid medication according to said therapy protocol, said medical evaluation device (10) comprising: a communication unit (100), configured to establish a communication connection with a communication device (20), said communication connection being configured for: providing first configuration data to a nebulizer control device (40) of said aerosol nebulizer (30) via said communication device (20), said first configuration data for configuring said aerosol nebulizer according to said therapy protocol; and receiving nebulizing data indicating an operation of said aerosol nebulizer from said communication device (20); further comprising an evaluation unit (110), configured to evaluate said adherence to said therapy protocol based on a comparison of said received nebulizing data with respective ...

METHODS AND COMPOSITIONS FOR THE PREVENTION OF SUICIDE, HOMICIDE AND SELF-HARMING BEHAVIORS

Provided herein are methods and compositions for the treatment and/or prevention of: suicide, homicide, and/or self-harming behavior, comprising administration of a composition comprising xenon.

SYSTEMS AND METHODS OF AEROSOL DELIVERY WITH AIRFLOW REGULATION

METHOD AND DEVICE FOR DELIVERING AEROSOLIZED MEDICAMENTS

A device for accurately delivering aerosolized doses of a medicament disperses a measured amount of drug (40) in a measured volume of carrier gas (22) and transfers the resulting aerosol to a chamber (42) prior to inhalation by a patient. The chamber (42) is filled efficiently with the aerosol, and inhalation by the patient draws the aerosol dose into the lungs. This is followed by the inhalation of atmospheric air (96) that will push the initial dose well into the lung interior. The apparatus optimally includes a dose regulator (13a), a counter (13c), clock (13e), a dose memory (30) and a signal (32) to indicate when a dose is ready by inhalation. Optimal chamber designs are disclosed.

MEDICATION DISPENSER AND CARRIER THEREFOR

The specification describes a medication dispenser for receiving a pressurised medication container and discharging therapeutic doses therefrom. The medication dispenser comprises an elongate tubular body (11) with a cavity formed in the body and adapted to receive a medication container. Lateral aperture (19) is formed in the body and communicates with the cavity. A sleeve (12) is rotatably mounted to a first end region (13) of the medication dispenser. The sleeve (12) has a sleeve aperture (16) which moves into and out of alignment with the lateral aperture (19) during rotation of the sleeve. A mouthpiece (18) moves between a discharge position and a storage position with rotation of the sleeve. The tubular body has a longitudinal axis (22) which deviates away from the position of the extended mouthpiece, the deviation occurring outside the first end region (13). The invention may extend to a carrier (60) for use with the medication dispenser (10).

APPARATUS FOR ELECTRONIC DOSAGE COUNTER

An apparatus for dispensing medication having a canister containing medication to be dispensed to a user. The canister is movable in both a first and a second direction. The apparatus also includes a mouthpiece that provides a point of egress for the medication. The medication is dispensed to the user when the canister is moved in the first direction. Also included in the apparatus is a switch for completing an electrical circuit. The switch is activated when the canister is moved in the first direction closing the electrical circuit. The electrical circuit is opened when the canister moves in the second direction. A counter module is disclosed for performing a count upon the closure of the electrical circuit. The counter module also displays a dispensation history of the medication in the canister. The apparatus also includes a seal for isolating the counter module from the mouthpiece and the canister.

INHALATION DEVICE WITH INTEGRATED ELECTRONICS MODULE

A device (400) for delivering medication to a user includes a circular or elliptical body (410) that includes a mouthpiece (420), a flexible strip (401) of medication, a lever (424), and a mouthpiece cover (491), where the mouthpiece cover is rotatable about the body. An electronics module (120) includes a communication circuit (134), a power supply (126), a sensor system (128), and a switch. The lever is configured to actuate the switch when the lever is moved from a closed position to an open position. The lever is further configured to advance a dose of medication on the flexible strip when moved from the closed position to the open position. The switch switches the electronics module from an off state to an active state when the lever is actuated for a first time by a user. The electronics module is configured to not return to the off state thereafter.

INHALATION DEVICE FOR DRUGS IN POWDER FORM

To provide an inhalation device which has improved use properties, partic ularly advanced moisture protection while in use, an inhalation device (1) f or powder drugs is proposed comprising at least one storage chamber (13) for accommodating a plurality of drug powder doses and a dosing device which in cludes at least one dosing slider (15) which is movable approximately with a translatory movement in a dosing slider passage (16) at least from a fillin g position into an emptying position, wherein the inhalation device (1) furt her includes a device for inhalation-triggered automatic movement of the dos ing slider (15) from its filling position into the emptying position and a r eturn device for automatic movement of the dosing slider (15) back into the filling position.

DEVICES, SYSTEMS AND METHODS FOR MEDICAMENT DELIVERY

An apparatus (1000) includes a housing (1100), a medicament container (9000) and an actuator (4000). The apparatus includes a label configured to be coupled to a medicament delivery device The label includes a first surface and a second surface. The first surfac configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia (1400). The label further includes an electronic circuit system configured to output an electronic signal.

Nebulizer and method of operation of a nebulizer

Nebulizer and method of operation of a nebulizer comprising a cupel capable of containing a liquid and a vibrating member ( 4 ) capable of emitting, under the effect of a control signal originating from a control circuit ( 10 ), an ultrasound beam making it possible to transform the liquid into mist, in which the vibrating member ( 4 ) is sensitive to the sound wave produced during the transformation of the liquid into mist and detection means ( 14 ) detect the presence and/or the absence and/or the value of a sound signal originating from the vibrating member, or of a signal corresponding to a sound signal originating from said vibrating member.

Flow conditioner for a compact, low flow resistance aerosol generator

A flow conditioner for generating and diluting an aerosol comprising a first inlet adapted to receive a first volume flow of pressurized gas is described. A second inlet is adapted to receive a second volume flow of dilution gas and a third inlet adapted to receive a fluid to be converted into an aerosol. A nozzle is connected to the first and third inlet and has a nozzle orifice for outputting a first aerosol. A first dilution gas flow partitioner comprises a first set of openings penetrating the first flow partitioner and a second dilution gas flow partitioner that is spaced apart from the first dilution gas partitioner and comprises a second set of openings penetrating the second flow partitioner. The nozzle orifice is positioned in the proximity of the second dilution gas flow partitioner.

Personal air filtration device

A personal air filtration device and methods of using the same for providing a zone of filtered air proximate a breathing zone of a user are described. A blower provides an air flow to a head support which delivers the air flow to a zone proximate the users head. The air flow passes through a filter. The filter can be a point of delivery filter disposed about an air permeable surface of the head support. The delivered air flow can provide a laminar air flow defining a zone of filtered air about the user's breathing zone.

Aerosol medication inhalation system

An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

Visual indicator for an aerosol medication delivery apparatus and system

A delivery system includes a holding chamber with first, second and third openings, and independently moveable first, second and third flow control members. A delivery system includes a holding chamber and a flow control member including a flap pivotable from an at rest position in a direction toward an outlet of a user interface and away from an output end of the holding chamber in response to a pressure being applied thereto.

Discharging device for dispensing liquids

A discharging device for dispensing liquids having a housing, control electronics, a liquid storage receptacle, a discharge orifice, a conveying device actuable manually by a first actuator which transports the liquid to the discharge orifice from the storage receptacle and a blocking device, which in a blocked state blocks the actuation of the conveying device and in a released state allows actuation of the conveying device. The blocking device includes an interlock device movable relative to the housing between first and second positions and a movement of the interlock device from the first to the second position causes the blocking device to assume the released state. The interlock device is biased by a spring device in the direction of the second position and a first retaining device is provided which retains the interlock device in the first position and which is releasable by a signal from the control electronics.

Flameless electronic atomizing cigarette

A non-smokable electronic spray cigarette which provides nicotine without harmful tar. The cigarette may include a mouthpiece, a high frequency ionizer, nicotine solution storage and its container, control circuit, and a high temperature vaporization nozzle and attachments. The advantages of the present invention are smoking without tar, reducing the carcinogenic risk, the user still experiencing the pleasure of smoking and no fire danger.

Artificial smoke cigarette

An artificial cigarette, inhaler or other nebulizer device may include a housing, an air passage into the housing, a fog generator chamber within the housing connected to the air passage, a liquid source connected to the fog generating chamber, and a fog generator within the fog generating chamber for receiving liquid from the liquid source and creating an aerosol. The fog generator may be an ultrasonic nebulizer and/or a pneumatic nebulizer.

Inhaler for the administration of an anticholinergic

An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 μm, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 μm to 500 μm, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 √{square root over (kPa)} min/L containing the inhalable powder.

Counter for a fluid or powder dispenser device

A dose counter, the counter having a base body, with a rotary counter element assembled in the base body on a pin forming the axis of rotation. The rotary counter element co-operating with an actuator member adapted to cause the rotary counter element to turn each time the actuator member is actuated. The actuator member including a fastener for fastening to the base body ( 460 ) and arranged on a first side of the pin, and a substantially rigid support portion arranged on a second side of said pin. The support portion supporting an actuator element so that, on each actuation, the actuator element is moved in translation. The support portion is connected to the fastener via an elastically-deformable portion that surrounds the pin. The support portion is extended towards the pin by a substantially-rectilinear flexible branch that supports a lug adapted to co-operate with the counter element on each actuation.

Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease

A two-phase surgical procedure is disclosed for creating a pneumostoma to treat chronic obstructive pulmonary disease The first phase is a procedure to induce creation of a localized pleurodesis and is preferably performed as an outpatient procedure. The second phase is a procedure to introduce a surgical instrument into the lung via the pleurodesis to create the pneumostoma. An interval of about one of more days between the first and second phases allows the formation of a stable pleurodesis to prevent pneumothorax during the procedure.

Medical aerosol non-diluting holding chamber

A medical aerosol delivery device comprises a housing having a first opening and a second opening and defining a fluid passage between the first and second openings. The housing comprising a pressurized medical aerosol canister actuator having a canister receptacle disposed within the fluid passage and having a valve chamber comprising a fine bore nozzle positioned to direct atomized medicament toward the first opening. The fluid passage includes an annular portion bypassing the canister receptacle and the housing comprises a movable closure member for selectively obstructing the fluid passage.

Dose delivery device for inhalation

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Nebulizer

A nebulizer which has an insertable container and a counter device for counting operations of the nebulizer, and is opened for replacing the container. A securing device having locking portions which are forced apart is provided to prevent reconnection of an already used container. The nebulizer has an indicator for showing the current container number and/or symbols indicating the need container replacement. The indicator is driven by the force of an internal spring. The indicator member also controls a lock of the container for locking the container against further actuation. The lock is reset after container replacement.

Method and Apparatus for Recognition of Inhaler Actuation

A medication confirmation method and apparatus for confirming administration of medication employing an inhalable medication administration apparatus. The method of an embodiment of the invention includes the steps of capturing one or more video sequences of a user administering medication employing the inhalable medication administration apparatus, storing the captured one or more video sequences, capturing one or more audio sequences of the user administering medication employing the inhalable medication administration apparatus and storing the captured one or more audio sequences. At least one of the stored video sequences and at least one of the stored audio sequences are then analyzed to confirm that the user has properly administered the medication.

Inhaler For Powdered, Particularly Medical Substances

The invention relates to an inhaler for powdered, particularly medical substances, comprising a suction air duct that extends to a mouthpiece, a reservoir for the substance, and an at least linearly movable dosing chamber for separating a specific amount of the substance from the reservoir and placing the amount into a transfer position in order for the same to be transferred to the suction air flow. In order to further develop a generic inhaler in an advantageous manner, especially so as to charge the dosing chamber by separating a specific amount of substance from the reservoir, the dosing chamber can be rotationally moved in a superimposed fashion while being arranged eccentric to a corresponding axis of rotation. 1. An inhaler for powdered , particularly medical substances , comprising:a suction air channel leading to a mouthpiece,a storage chamber for the substance; anda linearly moved dosing chamber for apportioning a specific amount of substance from said storage chamber and bringing said amount of substance into a transfer position, for transfer to said suction air stream,wherein said dosing chamber is rotationally moved in a superposed manner and is disposed eccentrically in relation to a corresponding axis of rotation (x).2. The inhaler according to claim 1 , wherein said dosing chamber is formed in a plunger slide.3. The inhaler according to wherein said plunger slide is formed as a flat part.4. The inhaler according to claim 2 , wherein said dosing chamber comprises a transverse bore running substantially perpendicularly in relation to the corresponding axis of rotation (x).5. The inhaler according to claim 2 , wherein said dosing chamber is disposed on said plunger slide in an orientation where said dosing chamber is situated near a side edge of a wide surface of said plunger slide claim 2 , and at a spacing from a free end of said plunger slide.6. The inhaler according to claim 1 , wherein said plunger slide interacts outside said storage chamber with ...

Nasal Delivery Devices

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container. 1a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet;a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber;a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; anda moisture-reducing element for reducing condensation at or downstream of the container chamber.. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: This application is a continuation of U.S. patent application Ser. No. 11/663,099, filed Aug. 22, 2007, which is a National Phase Application of International Application No. PCT/GB2005/003549, filed on Sep. 15, 2005, which claims the benefit ...

Nebulizer

A nebulizer is proposed which comprises a replaceable container containing fluid, a housing part detachable from the nebulizer for replacing the container, and an operation counter inseparable from the housing part as depicted in exemplary FIG. The operation counter comprises a lead screw and an associated rider both supported by the housing part. 112. Nebulizer () which is an inhaler for a fluid () , comprising:{'b': 3', '2, 'a replaceable container () containing the fluid (),'}{'b': 18', '1', '3', '3, 'a housing part (), which is detachable from the nebulizer () for replacing the container () and which is inseparable from the container (), and'}{'b': 5', '1', '3', '45', '18', '3', '18, 'an operation counter () counting uses of the nebulizer () with the associated container (), the operation counter () being inseparable from the housing part () for replacement together with the container () and housing part (),'}{'b': 45', '46', '47', '18, 'characterized in that the operation counter () comprises a first lead screw () and an associated, first rider () both supported by the housing part ().'}24647. Nebulizer according to claim 1 , characterized in that the first lead screw () and the first rider () are inseparable from the housing part.346182511171. Nebulizer according to claim 1 , characterized in that the first lead screw () is driven by relative rotation of the housing part () and/or during conveying of fluid () into a pressure generator () or pressure chamber () of the nebulizer () and/or during tensioning of a drive spring () of the nebulizer ().445125171183. Nebulizer according to claim 1 , characterized in that the operation counter () locks the nebulizer () against further use conveying of fluid () into a pressure generator () of the nebulizer () claim 1 , tensioning of a drive spring () of the nebulizer () claim 1 , rotation of the housing part () claim 1 , pressure generation and/or nebulization claim 1 , in a first locked state when a predetermined number ...

METHOD FOR USING A DRY POWDER INHALER

A method of using a dry-powder inhaler, including providing a dry-powder inhaler () having a body () containing a dispersion chamber (), a dispenser orifice () through which the user inhales, a loading opening () that receives a capsule () containing a dose of dry powder for inhaling, and at a movable portion () that moves relative to the body between a first end position and a second end position; inserting a full capsule () into the loading opening (); moving the movable portion from one of its end positions to its other end position to open the capsule and empty the powder into the dispersion chamber; inhaling the powder through the dispenser orifice; and returning the movable portion towards its initial position so as to open the dispersion chamber and eject the empty capsule. 1. A method of using a dry-powder inhaler , said method being characterized in that it comprises the following steps:{'b': 100', '200', '110', '210', '111', '211', '131', '231', '121', '220', '10', '130', '260, 'providing a dry-powder inhaler (; ) comprising: a body (; ) containing a dispersion chamber (; ); a dispenser orifice (; ) through which the user inhales; a loading opening (; ) that receives a capsule () containing a dose of dry powder for inhaling; and at least one movable portion (; ) that moves relative to said body between a first end position and a second end position;'}{'b': 10', '121', '220, 'inserting a full capsule () into said loading opening (; );'}moving said movable portion from one of its end positions to its other end position so as to open said capsule and empty the powder that it contains into said dispersion chamber;inhaling said powder through said dispenser orifice; andreturning said movable portion towards its initial position so as to open said dispersion chamber and eject the empty capsule from said dispersion chamber.2. A method according to claim 1 , wherein said movable portion is moved without contact with said dispenser orifice.3. A method according to ...

Small-volume oral transmucosal dosage forms

Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.

Apparatus, system and method for detection and delivery of a medicinal dose

An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.

AEROSOL DELIVERY SYSTEM WITH TEMPERATURE-BASED AEROSOL DETECTOR

An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor () in an aerosol output pathway of the system. A controller () determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis. 1. An aerosol delivery system comprising:an aerosol generator;an aerosol output opening;a fluid pathway extending from the aerosol generator to the aerosol output opening;a temperature sensor positioned to sense a temperature of the pathway; anda controller connected to the sensor to receive from the sensor a temperature signal that correlates with the temperature of the pathway,wherein the controller is constructed and arranged to use the temperature signal to detect the presence of aerosol in the fluid pathway.2. The system of claim 1 , wherein the output opening comprises a patient interface that is constructed and arranged to direct aerosol generated by the aerosol generator into a patient's airway.3. The system of claim 1 , wherein the system comprises a metered-dose inhaler.4. The system of claim 3 , wherein the controller is constructed and configured to use the temperature signal to detect a release of a bolus of aerosol from the metered-dose inhaler.5. The system of claim 4 , further comprising a bolus release indicator connected to the controller claim 4 , wherein the ...

Valved holding chamber including valve retention system

A valved holding chamber ( 2 ) includes a main chamber housing ( 49 and a mouthpiece assembly ( 6 ) removeably coupled to a first end of the main chamber housing, the mouthpiece assembly including a mouthpiece housing ( 24 ) having a mouthpiece portion ( 32 ) and a valve housing portion ( 30 ), a retaining ring ( 28 ) provided within and coupled to the valve housing portion, and a one-way inhalation valve ( 26 ) having an annular valve seat member ( 52 ), wherein the valve seat member is held between the retaining ring and an engagement surface of the valve housing portion. In one particular embodiment, a portion of the first end of the main chamber housing engages the bottom of the valve seat member and creates a seal between the main chamber housing and the one-way inhalation valve and between the one -way inhalation valve and the mouthpiece housing.

Dry powder inhaler

A dry-powder inhaler including a body containing a dispersion chamber; a dispenser orifice through which the user inhales; a loading opening that receives a capsule containing a dose of dry powder for inhaling; and at least one movable portion that moves relative to the body between a first end position and a second end position; the dispersion chamber containing at least a portion of an empty capsule at the moment of inhalation, the at least one capsule portion swirling in the dispersion chamber during inhalation so as to disperse and/or break up the powder.

Nebulizer that is activated by negative inspiratory pressure

A nebulizer includes an air channel section and medication reservoir. An air line extends through the air channel section. A venturi nozzle is at its end and configured to form a low pressure mixing chamber. A vent is formed in the body and communicates with the air channel section and medication reservoir to vent the air channel section and medication reservoir to outside ambient air. A primary suction line extends from the medication reservoir to the low pressure mixing chamber through which medication is drawn upward and mixed with air passing through the venturi nozzle and nebulized for discharge. The vent is configured to vent the air channel section and medication reservoir to atmospheric pressure such that at standard temperature and pressure (STP), a differential pressure results between the venturi nozzle and medication reservoir such that no medication is drawn upward through the primary suction line.

MODULAR PULMONARY TREATMENT SYSTEM

A patient interface system for delivering a gas to a patient includes a patient interface device that includes at least one inhalation valve and at least one exhalation valve. The system also includes a venturi device that has at least one port for connection to a gas source. The venturi device has at least one primary air entrainment window and at least one secondary air entrainment window which is downstream of the at least one primary air entrainment window. The inhalation valve is disposed between: (1) the main body and (2) the primary and secondary air entrainment windows of the venturi device. At least one of the primary air entrainment window and secondary air entrainment window includes a means for closing the respective window, thereby changing a degree at which the respective window is open and changing a flow rate of the air flowing through the respective window. 1. A patient interface device for delivering a gas to a patient comprising:a main body for placement against a face of the patient, the main body including a conduit portion that is open at a first end to a hollow interior of the main body and a free second end for attachment to another object in a sealed manner;at least one exhalation valve assembly that is disposed within a first port formed in the main body and includes an exhalation valve member that is configured to vent exhaled air when open;a primary inhalation valve assembly that is disposed within the conduit portion and includes a primary valve member that moves between open and closed positions; anda secondary inhalation valve assembly that is disposed within a second port formed in the main body and includes a secondary valve member that moves between open and closed positions;wherein the body includes an HME (heat moisture exchange) seat for receiving an HME unit and being located in relationship to the least one primary inhalation valve assembly and the at least one exhalation valve assembly to: (1) allow passage of inhaled gas, ...

Inhaler

An inhaler, the inhaler including a body ( 104 ) and a cartridge ( 106 ), the cartridge comprising a dose storage portion ( 122 ) and an airway ( 124 ), 102 the dose storage portion being suitable for containing a plurality of doses of an inhalable medicament, the airway including a mouthpiece ( 128 ) at an end thereof, the inhaler device configured and arranged such that a dose of inhalable medicament from the dose storage portion can be accessed and arranged in a delivery configuration for delivery to a user through the airway upon inhalation through the mouthpiece by the user, the inhaler characterised in that the cartridge is replaceably removable from the body.

METHOD AND DEVICE FOR CLAMPING A BLISTER WITHIN A DRY POWDER INHALER

The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein individual blister packs are positioned within the housing to be simultaneously engaged with the flow channel and the vibration element. The flow channel includes a blister pack clamping surface that engages the blister pack near the top of the crown and allows the blister three rotational degrees of freedom. The advantages of this arrangement include improved consistency and higher airspeed of the synthetic jet, as well as other advantages. 1. A medication inhaler , comprisinga housing for accommodating a blister containing a medication;a vibrating element within the housing; anda chamber defining a flow channel communicating with the blister, wherein the blister is clamped in position adjacent the vibrating element by the chamber.2. The inhaler of claim 1 , wherein the blister comprises a first face and a second face claim 1 , the second face being positioned in contact with the vibrating element.3. The inhaler of claim 1 , wherein the blister comprises a first face and a second face claim 1 , the first face having a crown claim 1 , the first face being engaged at least in part with the chamber.4. The inhaler of claim 3 , wherein the chamber further comprises a blister pack clamping surface claim 3 , allowing three rotational degrees of freedom between the chamber and blister pack.5. The inhaler of claim 3 , wherein the chamber further comprises a blister pack clamping surface that surrounds claim 3 , at least in part claim 3 , the crown of the blister pack.6. The inhaler of claim 5 , wherein the blister pack clamping surface engages the first face of the blister pack that is closer to the top of the crown than to the base of the crown.7. The inhaler of claim 1 , wherein the vibrating element is a piezoelectric transducer.8. The inhaler of claim 1 , wherein the medication comprises a dry powder.9. The inhaler of claim 1 , wherein ...

MEDICINAL INHALATION DEVICES AND COMPONENTS THEREOF

A medicinal inhalation device having a non-metal coating applied by plasma deposition under ion bombardment conditions. 1. A method of making a medicinal inhalation device comprising:a) forming a non-metal coating on at least a portion of a surface of the device, said coating having at least one functional group;b) applying to at least a portion of a surface of the non-metal coating a composition comprising an at least partially fluorinated compound comprising at least one functional group; andc) allowing at least one functional group of the at least partially fluorinated compound to react with at least one functional group of the non-metal coating to form a covalent bond; andwherein the at least partially fluorinated compound comprising at least one functional group is a polyfluoropolyether silane, in particular a multifunctional polyfluoropolyether silane, and more particularly a difunctional polyfluoropolyether silane; and {'br': None, 'sub': f', '2', '3-x', 'x', 'y', 'z, 'sup': '1a', 'R[Q-[C(R)—Si(Y)(R)]]\u2003\u2003Ia'}, 'wherein the polyfluoropolyether silane is of Formula Ia [{'sub': 'f', 'Ris a monovalent or multivalent polyfluoropolyether segment;'}, 'Q is an organic divalent or trivalent linking group;', {'sub': '1-4', 'each R is independently hydrogen or a Calkyl group;'}, 'each Y is independently a hydrolysable group;', {'sup': '1a', 'sub': '1-8', 'Ris a Calkyl or phenyl group;'}, 'x is 0 or 1 or 2;', 'y is 1 or 2; and', 'z is 1, 2, 3, or 4., 'wherein2. A method according to claim 1 , wherein the polyfluoropolyether segment claim 1 , R claim 1 , comprises perfluorinated repeating units selected from the group consisting of —(CFO)— claim 1 , —(CF(Z)O)— claim 1 , —(CF(Z)CFO)— claim 1 , —(CFCF(Z)O)— claim 1 , —(CFCF(Z)O)— claim 1 , and combinations thereof; wherein n is an integer from 1 to 6 and Z is a perfluoroalkyl group claim 1 , an oxygen-containing perfluoroalkyl group claim 1 , a perfluoroalkoxy group claim 1 , or an oxygen-substituted ...

INHALER TO DELIVER SUBSTANCES FOR PROPHYLAXIS OR PREVENTION OF DISEASE OR INJURY CAUSED BY THE INHALATION OF BIOLOGICAL OR CHEMICAL AGENTS

A dry powder inhaler may include a powder storage region, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel. 1. A dry powder inhaler , comprising:a powder storage region that is configured to hold a powdered medicament effective for treating exposure to particular biological and chemical agents;an inlet channel;a dispersion chamber that is adapted to receive air and the powdered medicament from the inlet channel, the chamber holding an actuator that is movable within the dispersion chamber; andan outlet channel through which air and aerosolized medicament exit the inhaler to be delivered to a patient;wherein a geometry of the inhaler is such that a flow profile is generated within the dispersion chamber that causes the actuator to oscillate, thus enabling the actuator when oscillating to deaggregate the powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to the patient through the outlet channel.2. The dry powder inhaler of claim 1 , wherein the powdered medicament effective for treating exposure to biological and chemical agents is stored upstream of the dispersion chamber claim 1 , and wherein the actuator when oscillating effectively disperses the powdered medicament effective for treating exposure to biological and chemical to be aerosolized and entrained by the air and delivered to the patient through the outlet channel.3. The dry powder inhaler of claim 1 , wherein the actuator is adapted to be coated with a particular powdered medicament effective for treating exposure to biological and chemical agents claim 1 , and wherein the actuator when oscillating ...

INHALER

An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. 170-. (canceled)7175-. (canceled)76. An inhaler comprising a housing to receive a blister having a puncturable lid and containing a dose of medicament for inhalation by a user , a mouthpiece through which a dose of medicament is inhaled by a user , a blister piercing member comprising at least two discrete piercing heads operable to pierce a corresponding number of holes in said blister , an actuator comprising an arm pivotally mounted to the housing at one end , and an opening formed in the vicinity of each piercing head , at least one of said openings forming an airflow inlet into said blister and , at least one other of said openings forming an airflow outlet from said blister , the mouthpiece including a primary chamber having an outside air inlet in communication , via the primary chamber , with the or each airflow inlet opening and , a secondary chamber in communication with the or each airflow outlet opening such that , when a user inhales through the mouthpiece , air is drawn through the or each airflow inlet opening into the blister via the outside air inlet and the primary chamber to entrain the dose in the airflow , said entrained dose passing through the or each airflow outlet opening into the secondary chamber of the mouthpiece from where it is carried into the user's airway.77. An inhaler according to ...

INHALATION DEVICE

A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism. 1. A dry powder inhaler , comprising:a vibrating mechanism;a supply of a dry powder operatively coupled to the vibrating mechanism;a power source in communication with the vibrating mechanism;a sensor in communication with the vibrating mechanism; anda feedback control in communication with the sensor and the power source, whereby the feedback control controls power delivered to the vibrating mechanism.2. The dry powder inhaler as claimed in claim 1 , wherein the vibrating mechanism further comprises a piezoelectric transducer.3. The dry powder inhaler of claim 1 , wherein the sensor further comprises a voltmeter.4. The dry powder inhaler of claim 1 , further comprising a memory in communication with the feedback control claim 1 , whereby the memory stores at least one communication from the sensor to the feedback control relative to at least one communication from the feedback control to the power source.5. (canceled)6. The dry powder inhaler of claim 1 , further comprising a peak7. The dry powder inhaler of claim 1 , wherein the vibrating mechanism further comprises a piezoelectric transducer and the sensor detects voltage output from the piezoelectric transducer.8. The dry powder inhaler of claim 7 , wherein the feedback controller correlates a plurality of power forms delivered to the vibrating mechanism with a plurality of output from the sensor.9. The dry powder inhaler of claim 8 , wherein the feedback controller identifies a power characteristic of the plurality of power forms delivered ...

SELF-SENSING RESPIRATORY TREATMENT DEVICE

A respiratory treatment device comprising a self-sensing respiratory treatment device comprising: power supply means; a liquid dispensing element comprising an actuator and a dispensing aperture; electronic control means operable to control said actuator; liquid supply means; valving means; wherein said actuator is operable to execute in itself at least a dispensing function and a detecting function, the detecting function detecting at least characteristics external to the self-sensing respiratory treatment device and causing said actuator to generate a command signal, and wherein said electronic control means is operable to control said valving means and said actuator based on the reception of said command signal, wherein said actuator is a piezoelectric actuator, and the respiratory treatment device further comprising: a mouthpiece, and a fluidic interface, wherein said electronic control means and said piezoelectric actuator being arranged to detect a breathing pattern of a user through said mouthpiece. 1. Respiratory treatment device comprising: power supply means,', 'a liquid dispensing element comprising an actuator and a dispensing aperture through which liquid is to be dispensed by activation of the actuator,', 'electronic control means operable to control said actuator,', 'liquid supply means for connecting with a liquid reservoir to supply liquid from said reservoir to said liquid dispensing element,', 'valving means for allowing or blocking liquid to flow from said reservoir through said liquid supply means to said liquid dispensing element,', 'wherein said actuator is operable to execute in itself at least a dispensing function and a detecting function, the detecting function detecting at least characteristics external to the self-sensing respiratory treatment device and causing said actuator to generate a command signal, and', 'wherein said electronic control means is operable to control said valving means and said actuator based on the reception of ...

PARTICLE DISPERSION DEVICE FOR NASAL DELIVERY

A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user. 1. A controlled particle dispersion breathing method , the method performed by a user having a sinus , comprising:providing a nebulizer having a particle dispersion chamber to a user, the particle dispersion chamber capable of producing nebulized particles;activating the nebulizer;breathing a plurality of quick breaths as nebulized particles begin to flow out of the particle dispersion chamber;creating a pressure in the sinus of the user using the back of the throat;repeating the breathing of a plurality of quick breaths, holding the quick breaths and creating a pressure in the sinuses;breathing a plurality of long breaths; andrepeating the breathing of a plurality of quick breaths, holding the quick breaths, creating a pressure in the sinuses and breathing a plurality of long breaths.2. The method of wherein about five quick breaths are breathed.3. The method of wherein about two to four quick breaths are breathed.4. The method of wherein about three quick breaths are breathed.5. The method of wherein about three long breaths are breathed.6. The method of wherein about two long breaths are breathed.7. The method of wherein about one long breath is breathed.8. A nebulizer comprising:a nasal adapter;a vortex chamber in communication with the nasal adapter;an outflow tube in communication with the vortex chamber; anda housing, the housing having a medicine chamber in which the medicine is nebulized in communication with the outflow tube.9. The nebulizer of wherein the nebulizer is capable of delivery of particles sizes ranging from about 2 to about 50 microns.10. The nebulizer of wherein the nasal adapter has a lip.11. The nebulizer of wherein the nasal adapter has a width of about 1½ inches across a bridge of the nasal adapter and a length of about 1½ inches.12. The nebulizer of wherein ...

METHODS AND SYSTEMS FOR SUPPLYING AEROSOLIZATION DEVICES WITH LIQUID MEDICAMENTS

A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler. 1. A method for supplying a metered amount of a liquid medicament to an aerosolizing device , the method comprising:providing an aerosolization device comprising a housing having a mouthpiece, a vibratable member within the housing and disposed to eject liquid droplets through the mouthpiece, a reservoir to hold the liquid medicament until aerosolized by the vibratable member, and an opening in the housing that is in fluid communication with the chamber;providing a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed, wherein the dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed;grasping the dispenser with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip;inserting the tip into the opening in the housing;while grasping the dispenser, forcing the elongate body toward the tip to cause the ...

Inhalation Devices and Systems and Methods Including the Same

A collapsible inhalation device for use with a metered dose inhaler (MDI) dispenser includes an outlet end member, an inlet end member and a tubular, pliable, collapsible sleeve member attached at either end to the inlet and outlet members. The outlet end member includes a mouthpiece. The inlet end member includes an inlet port and an MDI dispenser mount structure configured to receive and engage the MDI dispenser. The inhalation device is positionable in each of an open position, wherein the sleeve member defines a chamber, and a closed position, wherein the sleeve member is collapsed and enveloped by the outlet end member and the inlet end member. When the inhalation device is in the open position with the MDI dispenser mounted in the MDI dispenser mount structure, a dose of the medication can be dispensed from the MDI dispenser into the chamber through the inlet port to mix with air in the chamber and thereby form a mixture of the air and the dose of the medication that can be inhaled by a patient from the chamber through the mouthpiece. 1. A collapsible inhalation device for use with a metered dose inhaler (MDI) dispenser , the MDI dispenser operable to dispense a dose of a medication therefrom , the inhalation device comprising:an outlet end member including a mouthpiece;an inlet end member including an inlet port and an MDI dispenser mount structure configured to receive and engage the MDI dispenser; anda tubular, pliable, collapsible sleeve member having first and second opposed ends attached to the inlet end member and the outlet end member, respectively;wherein the inhalation device is positionable in each of an open position, wherein the outlet end member and the inlet end member are spaced apart and the sleeve member is extended such that the outlet end member, the inlet end member and the sleeve member define a chamber, and a closed position, wherein the sleeve member is collapsed and the outlet end member and the inlet end member are proximate one ...

Spacer and components therefor

A spacer comprising a polycarbonate chamber and a flow valve located within the chamber. The chamber comprises: a first reservoir and a second reservoir; an inlet for admission of aerosolized medication into the first reservoir; an outlet for withdrawal of medication from the second reservoir; and a vent for expulsion of air from the second reservoir. The flow valve is adapted to: allow forward-flow of medication from the first reservoir to the second reservoir during user inspiration; substantially limit inflow of air through the vent into the second reservoir during user inspiration, substantially limit backflow of air or medication from the second reservoir to the first reservoir during user expiration; and allow expulsion of air from the second reservoir through the vent during user expiration.

Directional flow sensor inhaler

An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator.

INHALER

An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. 170-. (canceled)71. An inhaler comprising a housing to receive a single blister having a puncturable lid and containing a dose of medicament for inhalation by a user , a mouthpiece through which a dose of medicament is inhaled by a user , a blister piercing member and , an actuator pivotally mounted to the housing and operable to cause the blister piercing member to puncture the lid of a blister received in the housing such that , when a user inhales through the mouthpiece , an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.72. An inhaler according to claim 71 , wherein the blister piercing member comprises at least two discrete piercing heads operable to pierce a corresponding number of holes in a blister received in the housing claim 71 , the actuator comprising an arm pivotally mounted to the housing at one end and an opening being formed in the arm in the vicinity of each piercing head claim 71 , at least one of said openings forming an airflow inlet into a blister and claim 71 , at least one other of said openings forming an airflow outlet from a blister claim 71 , the mouthpiece including a primary chamber having an outside air inlet in communication claim 71 , via the primary chamber claim 71 , with ...

Systems for treating pulmonary infections

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Powder medicament mouthpiece and application

A powder medicament mouthpiece comprising at least one section of through suction tube ( 1 ) and a filter ( 2 ). One end of the suction tube is a medicament inlet, and the other end ( 16 a ) is a suction outlet. The filter ( 2 ) is arranged within the suction tube ( 1 ). The powder medicament mouthpiece can be connected to multiple models of dry powder inhalers to separate powder medicament from dry powder, and allows for significantly improved efficacy.

POWDER DISPERSION DEVICES AND METHODS

A dry powder inhaler may include a powder storage, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel. 1. A dry powder inhaler , comprising:a powder storage that is configured to hold a powdered medicament;an inlet channel that is adapted to receive air and powdered medicament from the powder storage;a dispersion chamber that is adapted to receive air and powdered medicament from the inlet channel, the chamber holding an actuator that is movable within the dispersion chamber; andan outlet channel through which air and powdered medicament exit the inhaler to be delivered to a patient;wherein the geometry of the inhaler is such that a flow profile is generated within the dispersion chamber that causes the actuator to oscillate, thus enabling the oscillating actuator to deaggregate the powdered medicament passing through the dispersion chamber to be entrained by the air and delivered to the patient through the outlet channel.2. The dry powder inhaler of claim 1 , wherein a cross-sectional area of a flow path through the inhaler undergoes a step increase at the entrance to the dispersion chamber.3. The dry powder inhaler of claim 1 , wherein a ratio of the diameter of the dispersion chamber to that of the inlet channel is within a range of about greater than 1.0 to about 3.0.4. The dry powder inhaler of claim 1 , wherein the inlet channel comprises a tube.5. The dry powder inhaler of claim 1 , wherein the inlet channel comprises a tube with a cross-section that varies along the length of the tube.6. The dry powder inhaler of claim 1 , wherein the outlet channel comprises a tube with a cross-section that varies along the ...

Drug Delivery Inhaler Devices

An adapter for fitting to a drug delivery device, the adapter including: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of said drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. A drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. 1. An adapter for fitting to a drug delivery device , said adapter comprising:an outlet for communication with the mouth of a patient;an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient;an inlet adapted for connection to a mouthpiece of said drug delivery device; andan air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.2. An adapter according to wherein said adapter is a substantially cylindrical tube.3. An adapter according to wherein said inlet is adapted for connection to a mouthpiece of a pressurised metered dose inhaler (pMDI) device.4. An adapter according to wherein said air flow rate indicator is adapted to generate an audible or visual signal.5. An adapter according to wherein the air flow rate indicator is operable electronically.6. Use of a drug delivery inhaler device to deliver a drug to a patient by inhalation claim 1 , the method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'connecting the inlet of an adapter according to to the mouthpiece of the drug delivery device;'}the patient inhaling through the outlet of the adapter ...

Aerosolization Device

An aerosol transfer device for medical aerosol generators comprises a body, fluidically coupled to a nebulizer and to a patient interface. An ambient air intake is formed into a lower body. The body is shaped and configured to optimize mixing of ambient air from the ambient air intake and the aerosol generated by the nebulizer, resulting in the formation of an aerosol plume having optimum characteristics for delivery of the aerosol to the patient's pulmonary system, such as the central or deep lung regions. The shape and dimensions of the body are further designed to minimize aerosol deposition, thus improving delivery efficiency. 1. A method of administering a medicament to a patient , the method comprisinginhaling a dose of an aerosolized medicament by the patient, wherein said dose of the aerosolized medicament is provided byan aerosol accumulation chamber having a central vertical axis, an upper end and a lower end, the chamber having a major dimension of at least 10 cm, the upper end comprising a nebulizer port and a patient interface port, the lower end comprising an air inlet port, wherein the air inlet port is oriented to be non-aligned with said central vertical axis, said air inlet port further comprising a valve, an outer shell, substantially surrounding the at least said lower end of the aerosol accumulation chamber, the outer shell having one or more air inlet passages about a periphery thereof wherein said one or more air inlet passages is above said air inlet port, said patient interface port fluidically coupled to a patient interface device, and an aerosolized exhaust port intermediate to said patient interface device and to said patient interface port;a vibrating mesh nebulizer that is fluidically coupled to said nebulizer port;a disposable patient interface device that is fluidically coupled to said patient interface port; anda liquid medicament for aerosolization to generate said dose of the aerosolized medicament via the vibrating mesh nebulizer, ...

NASAL DELIVERY DEVICES

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber. 1a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet;a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber;a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; anda moisture-reducing element for reducing condensation at or downstream of the container chamber.. A nasal delivery device for delivering substance to a ...

Integrated insulin delivery system with continuous glucose sensor

Systems and methods for integrating a continuous glucose sensor 12 , including a receiver 14 , a medicament delivery device 16 , a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

Indicating device

A dispenser for dispensing metered dosages of a substance from a container includes a dispenser housing having a top, a bottom, and a wall defining an elongated cavity open at the top and extending along a longitudinal axis. An indicating device includes a face member defining a viewing window. The face member is snap-fitted to the dispenser housing wall. The indicating device further includes an indicator member having a surface visible through the viewing window. The surface includes dosage indicia. The indicator member is rotatable about an axis substantially perpendicular to the longitudinal axis. An indicator actuator has at least a portion disposed in the cavity. The actuator is adapted to be moved by an actuation of the container, with the actuator adapted to rotate the indicator member upon a predetermined number of actuations of the container.

Metering Device for the Inhalation of a Pulverulent Substance

A metering device activated by a user induced airstream for an inhalation of a medicinal substance. The device includes: a closure cap; a piston; a mouthpiece; and an annular chamber disposed upstream of the mouthpiece. A storage chamber stores the substance which can be moved out of the storage chamber when the closure cap is removed. A metering rod for removing the medicinal substance out of the storage chamber into an emptying-standby position. In the emptying-standby position, the metering chamber is closed by the piston. The piston is displaceable by airstream into an emptying-release position. In the emptying-release position, a metering chamber is released and the substance removed by the suction airstream. The metering device includes an outer cylinder which accommodates an inner cylinder. 121-. (canceled)22. A metering device activated by a user induced airstream for an inhalation of a medicinal substance , the metering device comprising:a closure cap;a piston;a mouthpiece;an annular chamber disposed upstream of said mouthpiece;a storage chamber storing said medicinal substance which can be moved out of said storage chamber when said closure cap is removed; [ 'said piston being displaceable by said airstream into an emptying-release position,', 'in said emptying-standby position, said metering chamber being closed by said piston,'}, 'in said emptying-release position, said metering chamber being released and said substance removed by said suction airstream;, 'a metering rod comprising a metering chamber for removing said medicinal substance out of said storage chamber into an emptying-standby position,'}wherein the metering device comprises an outer cylinder which accommodates an inner cylinder.23. The metering device according to claim 22 ,wherein said metering rod passes through a center of said inner cylinder.24. The metering device according to claim 23 ,wherein in a cap closed position, a hollow cylinder of said closure cap passes through said center ...

Device For Administering A Powdered Medicament To A Patient By Inhalation

A device ( 1 ) for administering a powdered medicament to a patient by inhalation is described. The device ( 1 ) comprises a body ( 2 ), an internal housing ( 3 ) in the body ( 2 ), an inhalation channel ( 4 ), a mouthpiece ( 5 ), and a dose provisioning member ( 6 ). The dose provisioning member ( 6 ) comprises at least one cavity ( 7,7 a, 7 b, 7 c ) for accommodation of a powdered medicament, the dose provisioning member ( 6 ) further being enabled to adopt a first position in which the cavity ( 7,7 a, 7 b, 7 c ) is out of alignment with the inhalation channel ( 4 ) and a second position in which the cavity ( 7,7 a, 7 b, 7 c ) is in alignment with the inhalation channel ( 4 ). Each cavity ( 7,7 a, 7 b, 7 c ) is prefilled with a single dose ( 8,8 a, 8 b, 8 c ) of a powdered medicament, wherein the powdered medicament is solely stored in each cavity ( 7,7 a, 7 b, 7 c ) and the device ( 1 ) is free of a powder reservoir for storing a plurality of doses. A protective member ( 9 ) is provided within the housing ( 3 ), the protective member ( 9 ) being enabled to adopt a first position in which a part of the protective member ( 9 ) lies in the inhalation channel ( 4 ) such that the cross-section of the inhalation channel ( 4 ) is covered by a wall of the protective member ( 9 ) and to adopt a second position in which the protective member ( 9 ) does not lie in the inhalation channel ( 4 ) such that the cross-section of the inhalation channel ( 4 ) is not covered by a wall of the protective member ( 9 ).

Ultrasonic mist inhaler

The invention relates to an ultrasonic mist inhaler, comprising:a liquid reservoir structure comprising a liquid chamber adapted to receive liquid to be atomized,the liquid chamber comprising a top surface representing the maximum level of the liquid chamber and the bottom surface representing the minimum level of the liquid chamber,a sonication chamber in fluid communication with the liquid chamber,the sonication chamber comprising means of ultrasonic vibrations and a capillary element extending between the sonication chamber and the liquid chamber,wherein the means of ultrasonic vibrations and the liquid chamber are arranged according to one of the following configurations:the means of ultrasonic vibrations are disposed close to or at the bottom surface of the liquid chamber,the means of ultrasonic vibrations are disposed close to or at the top surface of the liquid chamber as depicted in FIG. 3.

DRUG DELIVERY DEVICE WITH ELECTRONICS AND POWER MANAGEMENT

A system may limit the number of times an inhalation device transmits inhalation data to a single time to reduce the battery usage of the inhalation device. The system may include an inhalation device that has medicament and an electronics module. The system may limit the number of times the inhalation device transmits new inhalation data to any mobile device to a single time by causing the server to receive the new inhalation data from one of the mobile devices and causing the server to transmit the new inhalation data to other of the mobile devices prior to the other mobile devices transmitting a request for the new inhalation data to the inhalation device. The inhalation device may include a Quick Response (QR) code, and a mobile application may determine at least one of a medication type or a number of doses of the inhalation device from the QR code. 1. A system comprising:a cloud-based server comprising a processor, memory, and a communication circuit;an inhaler comprising a mouthpiece, medicament, and an electronics module, the electronics module comprising a processor, memory, and a communication circuit; send a request for inhalation data to the inhaler;', 'receive the inhalation data from the inhaler, the inhalation data associated with a timestamp; and', 'transmit the inhalation data and timestamp to the cloud-based server; and, 'a first mobile application residing on a first mobile device, the first mobile device comprising a processor, a communication circuit, and memory, and the first mobile application configured to cause the processor of the first mobile device to transmit a request to the cloud-based server that includes an indication of a last synchronization time between the second mobile application and the inhaler; and', 'receive the inhalation data of the inhaler from the cloud-based server in response to the request, wherein the timestamp associated with the inhalation data is subsequent to the last synchronization time between the second ...

AUTHENTICATABLE INHALATION SYSTEM

An inhalation system including a fluid transfer member, a valve member, a cartridge assembly, and a mouthpiece, and a method of use thereof are provided. The valve member connects to an open end of the fluid transfer member. The cartridge assembly, positioned within the valve member, includes a substance holder and an absorbent member accommodated within a cartridge for containing and absorbing an inhaling substance. When the valve member connects to a vaporizer, the vaporizer heats the absorbent member to vaporize and release an inhaling fluid into the fluid transfer member. When the valve member connects to the mouthpiece, the valve member receives and transfers the inhaling fluid vapor from the fluid transfer member to a user's mouth via the mouthpiece. The locking mouthpiece assembly allows authentication of the user prior to releasing the inhaling fluid to the user's mouth. 1. An inhalation system comprising:a fluid transfer member comprising an open first end configured to receive an inhaling fluid;a valve member operably connected to the open first end of the fluid transfer member, wherein the valve member comprises a body, a first opening, and a second opening, wherein the first opening is configured to be connected to the open first end of the fluid transfer member, and wherein the second opening is configured to be connected to a mouthpiece and a vaporizer; a substance holder configured to contain an inhaling substance;', 'an absorbent member positioned proximal to the substance holder, wherein the absorbent member is configured to absorb the inhaling substance received from the substance holder; and', 'a cartridge configured to accommodate the substance holder and the absorbent member, wherein, when the second opening of the valve member is connected to the vaporizer, the vaporizer is configured to heat the absorbent member with the absorbed inhaling substance to a temperature lower than a combustible temperature of the inhaling substance for vaporizing ...

DRY POWDER INHALER AND SPACER DEVICE FOR A DRY POWDER INHALER

Provided is a Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device () comprising a bag () and a body () including inlet () and opposed outlet (), the inlet () and opposed outlet () being provided on, and integral with, the body (). The body () and bag () combine to form chamber () for operatively receiving vaporised dry powder medication. The inlet () and outlet () each are in the form of a port that is in fluid flow communication with the chamber (). The inlet () and outlet () define, and are separated by, a broad V-formation formed as part of the body (). The body () further includes an elliptical lower perimeter () defining flange (), for demountably receiving bag () 1. A Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device comprising:a body in the form of a generally V-shaped mounting formed by opposing inlet and outlet passages intersecting at an angle of between 30 and 170 degrees along their respective longitudinal axes; anda demountable, flexible bag attached below the body, the bag and body together defining a chamber, such that the inlet and outlet passages are in fluid flow communication with an interior of the chamber;wherein the inlet is configured for operative connection to the DPI containing a drug to be inhaled;wherein the outlet is configured to be operatively received by a user's mouth;wherein the DPI includes expulsion means for expelling a powdered drug from the DPI into the spacer device, said drug encapsulated in the form of a capsule, caplet, or gel covering, said expulsion means including piercing means for piercing said capsule, caplet or gel covering to liberate the powder prior to expulsion from the DPI; andwherein the flexible bag serves as reservoir to allow for the formation of a vapour or particle cloud of the drug to be inhaled therewithin following activation of the DPI, the flexible bag being configured to be at least ...

Spacer device for a nebuliser

Provided is a spacer device (110) for delivery of drugs via a nebuliser device, the space device (110) comprising a bag (112) and a body (118) including inlet (114) and opposed outlet (116), the inlet (114) and opposed outlet (116) being provided on, and integral with, the body (118). The body (118) and bag (112) combine to form chamber (120) for receiving aerosolised medication. The inlet (114) and outlet (116) each are in the form of a port that is in fluid flow communication with the chamber (120). The inlet (114) and outlet (116) define, and are separated by, a broad V-formation formed as part of the body (118). The body (118) further includes an elliptical lower perimeter (118.1) defining flange (118.2), for demountably receiving bag (112).

DIRECTIONAL FLOW SENSOR INHALER

An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator. 1. An air inhalation device for delivering medicament to a user , said device comprising:an acoustic controller, said acoustic controller including an acoustic sensing element configured to detect air flow around said acoustic sensing element and to produce signals that identify the direction and amplitude of said air flow; anda high frequency vibrator configured for inducing said medicament into said air flow when said signals indicate inhalation by said user.2. An inhalation device as claimed in claim 1 , further comprising an electrostatic plate positioned in said air flow for attracting selected particles of medicament thereto claim 1 , said electrostatic plate being configured to activate when said signals indicate inhalation by said user.3. An inhalation device as claimed in claim 1 , wherein said acoustic controller is adapted to stop the vibration of said high frequency vibrator when said signal indicates inhalation has stopped.4. An inhalation device as claimed in claim 3 , wherein said high frequency vibrator is adapted to turn off and on with amplitude of air flow.5. An inhalation device as claimed in claim 1 , wherein said signals control activation of a timer claim 1 , and said timer tracks cumulative inhalation time.6. An inhalation device as claimed in claim 5 , wherein said timer is adapted to provide feedback to said user when cumulative inhalation time exceeds a predetermined level.7. An inhalation device as claimed in claim 1 , wherein acoustic sensing element comprises an acoustic microphone element.8. An inhalation device as claimed in ...

SMART SPACER FOR AN INHALER

A spacer is provided comprising a chamber having an interior surface and an exterior surface. The interior surface is configured to receive aerosolized medicament from an inhaler and has at least one sensor for measuring airflow in the chamber. The spacer includes an actuator disposed on the exterior surface configured to initiate measurement of airflow in the chamber. Methods of making and using a spacer are also provided. 1. A spacer comprising a chamber having an interior surface and an exterior surface , the interior surface of the chamber configured to receive aerosolized medicament from an inhaler and having at least one sensor for measuring airflow in the chamber; and an actuator disposed on the exterior surface of the chamber configured to initiate measurement of airflow in the chamber.2. The spacer of claim 1 , wherein the interior surface of the chamber is configured to hold aerosolized medicament from the inhaler in the chamber.3. The spacer of claim 1 , wherein the interior surface of the chamber is configured to receive inhaled air and exhaled air from a patient.4. The spacer of claim 1 , wherein the inhaler is a metered dose inhaler (MDI) or a soft mist inhaler (SMI).5. A spacer comprising a chamber having an interior surface and an exterior surface claim 1 , the interior surface of the chamber configured to receive inhalation air and exhalation air from a patient claim 1 , the interior surface having at least one sensor for measuring airflow in the chamber; and an actuator disposed on the exterior surface of the chamber configured to initiate measurement of airflow in the chamber.6. The spacer of claim 5 , wherein the chamber comprises a proximal end opening and a distal end opening claim 5 , and the at least one sensor is disposed adjacent to the proximal end opening.7. The spacer of claim 6 , wherein the proximal end opening comprises a mouthpiece or a mask and the mouthpiece or the mask is configured for engagement with a mouth of the patient claim ...

Metered-Dose Inhaler Security System

Security features for an electronic metered-dose smart inhaler, mobile app, and cloud-based software system for use with medical prescriptions and clinical trial regimens. The smart inhaler requires several types of user validation and feedback, and enters a locked-out state when required user feedback is not received or when received user feedback raises a suspicion of fraudulent or improper use. While the smart inhaler system is well suited for aerosol medical marijuana products, it may be used to deliver and conduct clinical trials on any type of product suitable for aerosol administration including other types of medication and non-medical products, such as nicotine, herbal products, pain killers, sleep aids, dietary stimulants, dietary suppressants, etc. The security features are not limited to aerosol inhalers, and may be applied more widely to other types of in-home, patient-administered products. 1. An electronic metered-dose inhaler system including security features comprising a cartridge , a pump unit , and a mobile app , wherein: a canister containing pressurized contents for aerosol dispensing without burning or vaporizing the contents of the canister,', 'a mouthpiece unit holding the canister against a spring biasing the canister in a retraction direction allowing the canister to be reciprocated between the retraction direction and an opposing insertion direction to dispense a portion of the contents of the canister through the mouthpiece unit each time the canister is reciprocated,, 'the cartridge comprises a pump actuator positioned to reciprocate the canister to dispense the contents of the canister through the mouthpiece unit when the cartridge is attached to the pump unit in the operational configuration;', 'a battery powering a microprocessor, a memory, and a wireless radio;', 'wherein the memory is operative for storing the security information and associated security procedures;', 'wherein the microprocessor is operative for unlocking the pump ...

AEROSOL GENERATION WITH REDUCED SOUND GENERATION

The present invention relates to generating aerosols. In order to provide an improved aerosol generation with enhanced user friendliness, an aerosol generator () is provided that comprises an aperture structure () comprising a plurality of apertures, a transducer (), a reservoir space () for receiving a liquid, from which liquid droplets are to be generated in order to produce an aerosol, and a control unit (). The reservoir space is arranged adjacent to the aperture structure. The transducer is configured to generate a vibrational movement to be transferred as a relative movement between the liquid and the aperture structure. The control unit is configured to activate the transducer to vibrate for a first period having a first time to generate a relative movement between a liquid and the aperture structure, the movement being in a transverse direction to the aperture structure to urge liquid through the plurality of apertures to produce a plurality of droplets; and to pause the transducer for a second period having a second time; and to continuously repeat the activation and pause in an alternating manner. The control unit is further configured to randomly vary at least the second time for a following repeat loop at least after a determined maximum number of repetitions. 1. An aerosol generator comprising:an aperture structure comprising a plurality of apertures;a transducer;a reservoir space for receiving a liquid, from which liquid droplets are to be generated in order to produce an aerosol; anda control unit;wherein the reservoir space is arranged adjacent to the aperture structure; and wherein the transducer is configured to generate a vibrational movement to be transferred as a relative movement between the liquid and the aperture structure; wherein the control unit is configured to:activate the transducer to vibrate for a first period having a first time to generate a relative movement between a liquid and the aperture structure, the movement being in a ...

THERAPEUTIC VAPORIZER

A therapeutic vaporizer is disclosed having two or more housing portions configured to form an inner cavity. The housing portions are movable between an open and closed position, such that at least a portion of the inner cavity is enclosed when the housing portions are in the closed position. The vaporizer includes at least one accessory-receiving element configured to receive at least one accessory within the inner cavity when the housing portions are in the closed position. 166-. (canceled)67. A therapeutic vaporizer , comprising:a housing;a gas flow device contained within the housing;a heater contained within the housing, the heater comprising a chamber and a heating element configured to selectively heat a gas flowed from the gas flow device and through the chamber; an inner bowl cavity comprising a first therapeutic material support configured for supporting a vaporizable material;', 'an inlet providing fluid communication between the inner bowl cavity and the chamber, and', 'an outlet providing fluid communication from the inner bowl cavity;, 'a bowl comprisingan intermediary conduit positioned between the heater and the bowl, the heater in fluid communication with the bowl via the intermediary conduit;a first temperature sensor configured to detect a first temperature proximate to or within a portion of the heater;a second temperature sensor configured to detect a second temperature proximate to or within a fluid pathway formed downstream of the heater;a temperature controller electrically connected to the first and the second temperature sensors and the heating element for controlling the temperature of a gas flowed through the bowl cavity; anda second therapeutic material support positioned proximate to the outlet of the bowl, the second therapeutic material support formed as a tray, a basin, a receptacle or another container configured to support an aromatic material selected from an oil, a liquid, a gel, a solid or a semi-solid material.68. The ...

ATOMISATION APPARATUS USING SURFACE ACOUSTIC WAVE GENERATION

An apparatus for atomising liquid, including a piezoelectric substrate () having a working surface (), and a peripheral edge () extending along a side of the working surface, an interdigital transducer () located on the working surface for generating surface acoustic waves (SAW) in the working surface, and a liquid delivery arrangement including a porous member () for supplying the liquid to be atomised, wherein the porous member is in contact with the peripheral edge of the piezoelectric substrate. 1. An apparatus for atomising liquid , including a piezoelectric substrate having a working surface , and a peripheral edge extending along a side of the working surface , an interdigital transducer located on the working surface for generating surface acoustic waves (SAW) in the working surface , and a liquid delivery arrangement including a porous member for supplying the liquid to be atomised , wherein the porous member is in contact with the peripheral edge of the piezoelectric substrate.2. An apparatus for atomising liquid according to claim 1 , wherein the porous member is positioned relative to the upper edge such that an upper surface of the porous member is spaced a distance from the working surface equal to or less than the thickness of a boundary layer located adjacent the working surface within the liquid drawn from the porous member by the SAW.3. An apparatus for atomising liquid according to claim 1 , wherein the interdigital transducer is a DART-SPUDT.4. An apparatus for atomising liquid according to claim 1 , wherein the interdigital transducer has a thickness of at least 1% of the SAW wavelength.5. An apparatus for atomising liquid according to claim 4 , wherein the thickness of the interdigital transducer is between 1 to 5% of the SAW wavelength.6. A method of pulmonary delivery of biological substances using an apparatus as claimed in .7. A method of pulmonary delivery according to claim 6 , wherein the biological substance includes stem cells.8. A ...

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

ATOMIZER

An atomizer is provided. The atomizer includes a battery rod, including a rod body, a battery, and a first electrical connection part arranged on the rod body and exposed from the rod body, wherein an end of the rod body is disposed with a receiving part, and the first electrical connection part is located in the receiving part, an atomizing head, including a housing and a second electrical connection part arranged on the housing and exposed from the housing, and a mechanical switch, arranged on the rod body and exposed outside the rod body, wherein the mechanical switch is electrically connected between the battery and the first electrical connection part, and configured to turn on or turn off an electrical connection between the battery and the first electrical connection part; wherein the first electrical connection part is in contact with the second electrical connection part when the atomizing head is inserted into the receiving part, the electrical connection between the battery and the first electrical connection part is turned on when the atomizing head is inserted into the receiving part and the mechanical switch is triggered, and thereby an electrical connection between the first electrical connection part and the second electrical connection part is turned on to supply a power to the atomizing head through the battery. Using the mechanical switch to control the battery rod whether supply a power to the atomizing head or not can ensure the effectiveness of triggering power supply for a long time. 1. An atomizer , comprising:{'b': 100', '110', '120', '110', '130', '110', '110', '110', '111', '130', '111, 'a battery rod (), comprising a rod body (), a battery () contained in the rod body (), and a first electrical connection part () arranged on the rod body () and exposed from the rod body (), wherein an end of the rod body () is disposed with a receiving part (), and the first electrical connection part () is located in the receiving part ();'}{'b': 200', ' ...

VACCINE ADMINISTRATION APPARATUS AND METHOD

A dispensing apparatus is for use by users to take a chamber, fill the chamber with an aerosolized vaccine or other medicament, and dispose of used chambers. A display provides instructions to encourage prompt inhalation by the user from a dispensed and filled chamber. The apparatus allows very fast administration of vaccines to large numbers of people. The aerosol dispenser apparatus detects the chamber is in correct position and delivers a pre-determined dose of aerosol. Once the dose is delivered a visual and/or audible indicator informs the user that the chamber is filled and that they can take the inhalation. The single dose aerosol chamber is optimized for efficient administration of an aerosol. 1. An aerosol dispensing apparatus comprising a controller , a dispenser with a support for a single dose aerosol chamber having a nebulizer delivery port and an inhalation port , and a nebulizer having an aerosol generator and an outlet conduit adapted to deliver an aerosol dose into the chamber via the nebulizer delivery port , wherein the dispenser is configured for automatic engagement of the nebulizer outlet conduit with the nebulizer delivery port and for separation after delivery of a dose.2. An apparatus of claim 1 , wherein the dispenser comprises an automated chamber handler for engagement of chambers with the nebulizer in an automated manner.3. An apparatus of claim 1 , wherein the nebulizer is configured to deliver doses according to a pre-set time at a pre-set flow rate.4. An apparatus of claim 1 , further comprising a chamber dispenser for dispensing chambers to users in proximity to the nebulizer.5. An apparatus claim 1 , further comprising a user interface with a display screen and/or a speaker claim 1 , and the controller is configured to generate user instructions for use of the apparatus and for inhalation from the chamber.6. An apparatus of claim 5 , wherein the controller is configured to instruct user inhalation from a chamber within a set period ...

DELIVERY DEVICES

A delivery device for delivering a metered amount of substance (L) in response to exhalation by a user, the delivery device comprising: a mouthpiece () through which the user in use exhales; an outlet () from which substance Is delivered; and a dispensing unit () which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member () which includes a cavity () for containing a metered amount of substance, an outlet nozzle () which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing () member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle. 1. A delivery device for delivering a metered amount of substance in response to exhalation by a user , the delivery device comprising:a mouthpiece through which the user in use exhales;an outlet from which substance is delivered; anda dispensing unit which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member which includes a cavity for containing a metered amount of substance, an outlet nozzle which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle.2. The delivery device of claim 1 , wherein the cavity is an elongate cavity.3. The delivery device of claim 2 , wherein the cavity has a cylindrical section and the dispensing member comprises a ball which is moved along the cavity by the driving pressure created by ...

Assembly for an inhalation device and use of a sealing member

An assembly for an inhalation device is provided having a storage chamber configured to hold a plurality of doses of a substance, a metering element configured to be moved with respect to the storage chamber and having, a metering chamber, wherein a sub-quantity of the substance can be retrieved from the storage chamber by means of the metering chamber when the metering element is moved in a dosing direction with respect to the storage chamber The assembly also includes a sealing member mechanically cooperating with the metering element, that has an opening which receives the metering element, a main part and a sealing lip, wherein the sealing lip and the main part define a recess, wherein the recess is arranged between the sealing lip and the main part and, wherein the sealing lip is deflectable into the recess. A method using a sealing member for mechanical cooperation with a metering element of an inhalation device is also described.

DISPENSER HAVING A SYSTEM FOR DETECTING DISCHARGE PROCESSES

Dispenser for the discharge of pharmaceutical media having a liquid storage, a base body, an actuating handle that is manually displaced with respect to the base body for causing a discharge process of media from the liquid storage into an environment, and an electronic detection system for detecting discharge processes. A sensor is provided, which, subject to the displacement of a reference component mechanically coupled to the actuating handle such that during a discharge process the reference component is displaced with respect to the base body, generates an output signal. The sensor is configured for generating output signals of two distinguishable types as a function of the extent of the displacement, and is provided with an electronic calibration memory in which calibration data regarding discharge behavior of the dispenser are stored. 1. A dispenser for discharging pharmaceutical media , witha liquid reservoir,a base body,an actuating handle which is manually displaceable with respect to the base body in order to cause a process involving discharge of medium from the liquid reservoir into an environment, andan electronic detection system for detecting discharge processes,whereinthe detection system has:a sensor which generates an output signal depending on the displacement of a reference component that is mechanically coupled to the actuating handle such that it is displaced with respect to the base body during a discharge process, wherein the sensor is configured to generate output signals of at least two distinguishable types as a function of the extent of the displacement, andan electronic calibration memory, in which calibration data concerning the discharge behavior of the dispenser are stored.2. The dispenser as claimed in claim 1 ,whereinthe detection system has an evaluation device for processing the outlet signals, which evaluation device evaluates the discharge process by taking account of the type of the output signals.3. The dispenser as claimed ...

RELEASABLE MONITOR WITH OPTICAL DOSE COUNTER FOR A MEDICAMENT INHALER

Some embodiments are directed to a device for monitoring patient usage of a medicament inhaler. The medicament inhaler can be configured to deliver doses of medicament, and can include parts which move during the dispensing of a dose of medicament. The device includes a housing, for releasable attachable to the medicament inhaler, and an optical dose counter associated with the housing. The optical dose counter can be configured to determine when a dose of medicament has been dispensed by transmitting optical signals through the medicament inhaler. The device is attachable to the medicament inhaler, and is subsequently operable, without any modifications being required to be marks to the medicament inhaler. The device can also include an electronic control module which is in communication with the optical dose counter, the electronic control module being adapted to monitor and/or store data relating to patient usage of the medicament inhaler. 1. A device for monitoring patient usage of a medicament inhaler , said medicament inhaler being adapted to deliver doses of medicament , and wherein said medicament inhaler includes parts which move during the dispensing of a dose of medicament , wherein said device includes:a) a housing, said housing being releasably attachable to said medicament inhaler,b) an optical dose counter associated with said housing, said optical dose counter being adapted to determine when a dose of medicament has been dispensed by transmitting optical signals through the medicament inhaler,c) an electronic control module associated with said housing, said electronic control module including, or being in communication with, said optical dose counter, 'the arrangement and construction being such that said device is attachable to said medicament inhaler, and subsequently operable, without any modifications being required to be made to said medicament inhaler.', 'd) said electronic control module being adapted to monitor and/or store data relating to ...

Dose counter with lockout mechanism

A medicament dispenser, in particular a metered dose inhaler, which is able to count the number of time the dispenser is activated and then disable the device, which then prevents any additional medicament from being dispensed. Additional embodiments include a medicament dispenser which are adapted to display either the number of activations that have occurred or the number of activations remaining.

AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER

An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor. 1. An airflow adaptor for a breath-actuated dry powder inhaler , the airflow adaptor comprising:a first conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the first conduit, and wherein the airflow adaptor further comprises at least one second conduit for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the first conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor, andwherein the distal end of the first conduit comprises a first circumferential flange and the second conduit is in the form of at least one aperture in the first circumferential flange.2. An airflow adaptor according to wherein a ratio of the sum of the cross-sectional areas of the at least one second conduit to the cross-sectional area of the first conduit is such that when a breath induced low pressure is applied to the distal end of the airflow adaptor at least 5% claim 1 , preferably at least 20% claim 1 , of the resulting airflow is through the at least one second conduit.3. An airflow adaptor according to wherein the first circumferential flange comprises two claim 1 , preferably four apertures.4. An airflow adaptor according to wherein the airflow adaptor comprises a second circumferential flange at the proximal end of the airflow adaptor claim 1 , ...

USE OF NANOPARTICLES FOR TREATING RESPIRATORY INFECTIONS ASSOCIATED WITH CYSTIC FIBROSIS

This disclosure relates to metal nanoparticle compositions and methods for treating respiratory infections associated with cystic fibrosis. An amount of nonionic, ground state metal nanoparticles are administered to a patient via inhalation. The metal nanoparticles have properties that enable effective transport through the viscous mucus layer to the epithelia and surrounding tissues, killing or deactivating infecting microbes at the targeted respiratory tissue and throughout the overlying mucus layer. 1. A method for treating a respiratory infection , the method comprising: nonionic, ground state, spherical metal nanoparticles, and', 'a carrier formulated for administration via inhalation; and, 'administering a treatment composition to a patient via inhalation, wherein the treatment composition comprises'}the treatment composition treating the respiratory infection.2. The method of claim 1 , wherein the respiratory infection is associated with cystic fibrosis.3. The method of claim 1 , wherein the treatment composition effectively penetrates mucus of the patient to kill or deactivate microbes within the mucus and to reach underlying respiratory tissue.4. The method of claim 1 , wherein the treatment composition is nebulized prior to administration to the patient.5Staphylococcus aureus, Escherichia coli, Listeria, Salmonella, PseudomonasAcinetobacter, Strenotrophomonas maltophilia, AchromobacterBurkholderia cepacia. The method of claim 1 , wherein the respiratory infection comprises an infection with one or more of claim 1 , nontuberculosis mycobacteria claim 1 , claim 1 , or complex.6Staphylococcus aureusPseudomonasPseudomonas aeruginosa, Strenotrophomonas maltophiliaBurkholderia cepacia. The method of claim 1 , wherein the respiratory infection comprises an infection with one or more of methicillin-resistant claim 1 , tobramycin-resistant claim 1 , multidrug-resistant claim 1 , or complex.7. The method of claim 1 , wherein the respiratory infection comprises an ...

INHALABLE COMPOSITIONS FOR USE IN THE TREATMENT OF PULMONARY DISEASES

The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (), the nebulizer comprising: a) an aerosol generator () comprising: a fluid reservoir () for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and a vibratable membrane () having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 4.0 gm as measured with a 0.9% (w/v) aqueous solution of sodium chloride; b) a chamber () for temporarily accommodating the aerosol generated by the aerosol generator (), the chamber having an inner lumen with a volume in the range of from about 50 to about 150 ml; and c) a mouthpiece () for delivering the aerosol supplied by the nebulizer () to the subject, the mouthpiece having an exhalation filter (). 132-. (canceled)33. A pharmaceutical composition comprising cyclosporine A in liposomally solubilized form (L-CsA) for use in the prevention or treatment of a pulmonary disease or condition in a subject ,wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and{'b': '100', 'wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (), the nebulizer comprising{'b': '101', 'claim-text': [{'b': '103', 'a fluid reservoir () for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and'}, {'b': '110', 'a vibratable membrane () having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets ...

MEDICAMENT DELIVERY DEVICE

A medicament delivery device is presented having a housing that is arranged to accommodate a medicament container; a drive unit operably arranged to act on the medicament container upon activation; an activation mechanism operably arranged to be operated by a user; an activation preventing mechanism operably arranged to prevent said activation mechanism to be activated; an identification module arranged to be operated by a user, which identification module is designed as an attachable unit to the medicament delivery device; mechanical keying elements arranged on said device and on said identification module designed to interact with each other when attaching said identification module; first electrical keying elements comprised in said identification module, wherein said electrical keying elements are capable of obtaining identification information, such that the identification information obtained is compared to stored data and authenticated by the identification module, and wherein the authentication causes a deactivation of the activation preventing mechanism to allow operation of the activation mechanism. 117-. (canceled)18. A medicament delivery device comprising a housing , which housing is arranged to accommodate a medicament container ,a drive unit operably arranged to act on the medicament container upon activation,an activation mechanism operably arranged to be operated by a user,an activation preventing mechanism operably arranged to prevent said activation mechanism to be activated,an identification module arranged to be operated by a user, which identification module is designed as an attachable unit to the medicament delivery device,mechanical keying elements arranged on said device and on said identification module designed to interact with each other when attaching said identification module,first electrical keying elements comprised in said identification module, wherein said electrical keying elements are capable of obtaining identification ...

INHALER

An inhaler for delivery of a medicament by inhalation is disclosed. The inhaler comprises the following components. An inhaler body for receiving a canister having a dispensing valve. A drive mechanism comprising a biasing means such as a spring and a moving component such as a yoke, the drive mechanism for driving the canister, when received in the inhaler body, from a rest position in which the valve is closed to at least an actuating position in which the valve is open. The drive mechanism drives the canister when the biasing means is released from a loaded configuration to move the moving component from a first position to a second position. A resetting mechanism, for example a mouthpiece cap arrangement for pushing upwardly on the yoke, for resetting the drive mechanism by moving the moving component from the second position to the first position and reloading the biasing means to the loaded configuration. A return mechanism for returning the canister from the actuating position to the rest position, wherein the return mechanism comprises a damping system, the damping system configured to enable the canister to automatically return from the actuating position to the rest position within a predetermined time period measured from the release of the biasing means from the loaded configuration. A method of operation of an inhaler is also disclosed. 1. An inhaler for delivery of a medicament by inhalation , the inhaler comprising:an inhaler body for receiving a canister having a dispensing valve;a drive mechanism comprising a biasing means and a moving component, the drive mechanism for driving the canister, when received in the inhaler body, from a rest position in which the valve is closed to at least an actuating position in which the valve is open, the drive mechanism driving the canister when the biasing means is released from a loaded configuration to move the moving component from a first position to a second position;a resetting mechanism for resetting the ...

VAPOR MIXING APPARATUS

A vapor blending device is provided, generally having a base, a carrier removably couplable to the base for carrying a first and second vapor generating system. The first and second vapor generating systems including airflow generators and controllers configured to vary voltage to each of the first and second vapor generating devices and the airflow generators. A container is positioned in fluid communication with the first and second vapor generating systems and configured to retain a quantity of vapor. In some examples, one controller is configured to cause the first vapor generating system to generate a quantity of a first vapor, and another controller is configured to cause the second vapor generating system to generate a quantity of a second vapor in a predetermined ratio to the quantity of the first vapor. The vapor in the predetermined ratio is stored in the container for later removal. 1. A vapor blending device , comprising:a base;a carrier removably couplable to the base and having a first aperture and a second aperture; a first vapor generating device having a first heating element positioned within the first aperture, the first vapor generating device having a portion protruding through the carrier away from the base;', 'a first airflow generator positioned in the base and in fluid communication with the first vapor generating device; and', 'a first controller in electrical communication with the first heating element of the first vapor generating device and the first airflow generator, the first controller configured to vary voltage to one or more of the first heating element of the first vapor generating device and the first airflow generator;, 'a first vapor generating system comprising a second vapor generating device having a second heating element positioned within the second aperture, the second vapor generating device having a portion protruding through the carrier away from the base;', 'a second airflow generator positioned in the base and in ...

METERED DOSE INHALER ADD-ON DEVICE, OBSERVANCE IMPROVEMENT SYSTEM AND METHOD FOR IMPROVING OBSERVANCE OF USE IN METERED DOSE INHALERS

The present invention relates to an add-on device for a metered dose inhaler, an observance improvement system, and a method for improving observance of use in metered dose inhalers, the add-on device comprising an observance system housing component comprising an observance system with at least one pressure sensor; a mouthpiece component configured to fit, surround and removably engage with an exterior surface of a mouthpiece outlet provided on the metered dose inhaler; wherein said observance system housing is configured to fit and removably engage with said mouthpiece component; and said mouthpiece component is specifically adapted to conform to the exterior surface of the mouthpiece outlet of the metered dose inhaler without obstructing delivery of a dose of drug through said outlet. 1) Metered dose inhaler observance add-on device adapted to be removably mountable onto an exterior surface of a metered dose inhaler , said add-on device comprising:an observance system housing component comprising an observance system with at least one pressure sensor;a mouthpiece component configured to fit, surround and removably engage with an exterior surface of a mouthpiece outlet provided on the metered dose inhaler; whereinsaid observance system housing is configured to fit and removably engage with said mouthpiece component; andsaid mouthpiece component is specifically adapted to conform to the exterior surface of the mouthpiece outlet of the metered dose inhaler without obstructing delivery of a dose of drug through said outlet.2) Metered dose inhaler add-on device according to claim 1 , wherein said mouthpiece component and said observance system housing component form an air flow passage when assembled together claim 1 , and the at least one pressure sensor of the housing component is located at a position along said air passage.3) Metered dose inhaler add-on device according to claim 1 , wherein the at least one pressure sensor is configured to detect at least one or ...

INDUCTION SPACER FOR INHALER

A spacer for an inhaler includes a housing defining a chamber. The housing has an ambient port in fluid communication with ambient air, an inhaler port configured for attachment of an inhaler, and an outlet. The spacer further includes a fan for generating a flow of air through the chamber from the ambient port to the outlet. The fan may be powered by way of a spring such that the fan generates the flow of air as stored energy is released from a spring. Embodiments of the spacer may have an actuator for triggering a release of stored energy from the spring thereby actuating the fan. A mask or mouthpiece may be provided at the outlet. 1. A spacer for an inhaler , comprising:a housing defining a chamber, the housing having an ambient port in fluid communication with ambient air, an inhaler port configured for attachment of an inhaler, and an outlet;a fan for generating a flow of air through the chamber from the ambient port to the outlet; anda primer operable by a user to provide energy for powering the fan.2. The spacer of claim 1 , wherein the fan is powered by way of a spring such that the fan generates the flow of air as stored energy is released from a spring claim 1 , and further comprising an actuator for triggering a release of stored energy from the spring thereby actuating the fan.3. The spacer of claim 2 , wherein the actuator is further configured to actuate the inhaler such that a dose of medicament is released from the inhaler into the flow of air.4. The spacer of claim 1 , wherein the fan is located between the ambient port and the inhaler port.5. The spacer of claim 1 , wherein the fan is located between the inhaler port and the outlet.6. The spacer of claim 1 , wherein the primer is a lever.7. The spacer of claim 1 , wherein the primer is a rotatable knob.8. The spacer of claim 1 , further comprising an oronasal mask coupled to the outlet of the housing.9. The spacer of claim 8 , wherein the mask is releasably coupled to the outlet.10. The spacer of ...

LARGE DOSE DISPOSABLE INHALER AND METHOD OF SIMPLE FILLING

A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body () and a cartridge () with a plurality of powder compartments () each including one dose of a drug. The body () has an opening () shaped for receiving the cartridge () and the plastic body recess () and the detent () to allow a controlled advancement and turning movement of the cartridge () relative to the body () for sequentially delivering each of the plurality of unit doses filled into the cartridge compartments (). The inhaler construction is suitable for filling the plurality of unit doses into the compartments () with the cartridge () assembled into the body (). The invention affords a large dose inhaler of single-use and low cost that improves industrial filling and manufacturing cost for the delivery of high dosages of inhaled medicines. 1. A dry powder inhaler suitable for pulmonary or nasal delivery , comprising an inhaler body and a cartridge the inhaler comprising:{'b': 204', '226', '426', '626, "a. an inhaler body comprising a mouthpiece; an inhalation channel for providing fluid communication between the patient's mouth when engaged with the mouthpiece; a bottom channel inlet; side inlets for allowing direct air admission from atmosphere into the inhalation channel; an inhaler body opening () formed in the inhaler body and defined between opposing top and bottom walls and opposing side walls (, , ), said inhaler body opening having at least one end open by means of which the cartridge may be mounted into the opening; one or more plastic body protrusions for engaging and locking the cartridge once mounted in said inhaler body opening; one or more body rails in the said inhaler body opening shaped for receiving the cartridge and one or more body recesses and detents commonly adapted for movement of the cartridge relative to the body; and"}b. a cartridge comprising a plurality of powder compartments of tapered cylindrical or near-cylindrical shape formed therein for ...

SYSTEM AND METHOD FOR A VAPORIZER

A method for controlling a vaporizer device may include determining a first temperature, vaporizing an inhalable substance at the first temperature, raising the first temperature by a temperature quantity, wherein a second temperature is a sum of the temperature quantity and the first temperature; and vaporizing the inhalable substance at the second temperature, wherein the temperature quantity is less than 3° C. 1. A vaporizer device comprising:airflow tubing configured to deliver a gaseous substance to a user;a mouthpiece base configured to rotate between a first position and a second position; anda mouthpiece portion configured to couple to the mouthpiece base,wherein the mouthpiece base prevents the gaseous substance from escaping the airflow tubing in the first position and the mouthpiece base allows the gaseous substance to escape the airflow tubing in the second position.2. The vaporizer device of further comprising a housing.3. The vaporizer device of wherein the mouthpiece base is coupled to the housing.4. The vaporizer device of wherein the mouthpiece base is coupled to the housing through tabs that fit within indents in the housing.5. The vaporizer device of wherein the mouthpiece base is coupled to the housing via a hinge.6. The vaporizer device of further comprising a gasket coupled between the mouthpiece base and the airflow tubing.7. The vaporizer device of wherein the mouthpiece base engages the gasket in the first position to prevent the gaseous substance from escaping the airflow tubing.8. The vaporizer device of claim 6 , wherein the mouthpiece base includes a hole claim 6 , and wherein the gasket protrudes through the hole when the mouthpiece base is in the second position.9. The vaporizer device of claim 8 , wherein the mouthpiece portion includes a tube extending through the mouthpiece portion claim 8 , and wherein the tube engages the gasket to allow the gaseous substance to flow through the airflow tubing claim 8 , the gasket claim 8 , and ...

COMPLIANCE-ASSISTING MODULE FOR AN INHALER

An inhaler includes a mouthpiece cover, a pressure sensor, a first indicator and a second indicator. The first indicator may be configured to indicate based on a state of the cover, and the second indicator may be configured to indicate based on an output of the pressure sensor. For example, when the mouthpiece cover opens, the first indicator may illuminate and a dose of medication may be transferred from a reservoir to a dosing cup. The second indicator may illuminate if an amount of inhaled medication reaches a predetermined threshold for successful inhalation. 123-. (canceled)24. An inhaler comprising:a mouthpiece cover;a dosing cup;a medication reservoir configured to deliver a dose of medication into the dosing cup based on the mouthpiece cover moving from a closed position to an open position;a light; anda processor configured to control the light to be in a first state when the mouthpiece cover is in the closed position and control the light to be in a second state upon medication being delivered from the medication reservoir to the dosing cup.25. The inhaler of claim 24 , wherein the light is off when in the first state and the light is on when in the second state.26. The inhaler of claim 24 , further comprising a pressure sensor claim 24 , wherein the processor is configured to control the light to be in a third state based on an output of the pressure sensor.27. The inhaler of claim 26 , wherein the first state is off claim 26 , the second state is on claim 26 , and the third state is off.28. The inhaler of claim 26 , wherein the processor is configured to control the light to be in the third state when the output received from the pressure sensor exceeds a predetermined threshold.29. The inhaler of claim 28 , wherein the predetermined threshold is indicative of a successful inhalation from the inhaler by a user.30. The inhaler of claim 28 , wherein the output of the pressure sensor comprises a pressure measurement corresponding to an amount of airflow ...

Alpha 1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations

An alpha 1 -proteinase inhibitor delays the onset or progression of pulmonary exacerbations. In addition, methods delay the onset or diminish the progression of pulmonary exacerbations by the administration of inhaled alpha 1 -proteinase inhibitor.

HUFF COUGH SIMULATION DEVICE

A respiratory treatment device having an inlet configured to receive exhaled air into the device and an outlet configured to permit exhaled air to exit the device. A blocking member is moveable between a closed position where the flow of air through the device is restricted, and an open position where the flow of air through the device is less restricted. A biasing member is configured to bias the blocking member toward the closed position, wherein a level of bias decreases as the blocking member moves from the closed position to the open position. 1. A respiratory treatment device comprising:an inlet configured to receive exhaled air into the device;an outlet configured to permit exhaled air to exit the device;a blocking member moveable between a closed position where the flow of air through the device is restricted, and an open position where the flow of air through the device is less restricted; and,a biasing member configured to bias the blocking member toward the closed position, wherein a level of bias decreases as the blocking member moves from the closed position to the open position.2. The respiratory treatment device of claim 1 , wherein the biasing member comprises a pair of magnets.3. The respiratory treatment device of claim 2 , wherein a distance between a first magnet and a second magnet of the pair of magnets is selectively adjustable when the blocking member is in the closed position.4. The respiratory treatment device of claim 1 , wherein the blocking member moves from the closed position to the open position in response to a threshold exhalation pressure in the device.5. A respiratory treatment device comprising:an inlet configured to receive exhaled air into the device;an outlet configured to permit exhaled air to exit the device;a blocking member moveable between a closed position where the flow of air through the device is restricted, and an open position where the flow of air through the device is less restricted; and,a biasing member ...

DOSE COUNTING MECHANISM FOR AN AEROSOL DISPENSER

A dose counting mechanism for an aerosol dispenser is presented where the dose counting mechanism has a first body structure, a second body structure rotatably attached to the first body structure, an annular dose counter provided with a plurality of teeth along its perimeter, the dose counter being arranged coaxially with the first body structure and the second body structure, each of the first body structure and the second body structure being rotatable relative to the dose counter, a rotatable actuator that meshes with the teeth of the dose counter, the actuator being configured to follow the perimeter of the dose counter when the second body structure is rotated relative to the first body structure, and a rotator that rotates concurrently with one of the first body structure and the second body structure and that engages with the actuator when rotation of the first body structure relative to the second body structure is initiated. 115-. (canceled)16. A dose counting mechanism for an aerosol dispenser , wherein the dose counting mechanism comprises:a first body structure,a second body structure rotatably attached to the first body structure,an annular dose counter provided with a plurality of teeth along its perimeter, the dose counter being arranged coaxially with the first body structure and the second body structure, each of the first body structure and the second body structure being rotatable relative to the dose counter,a rotatable actuator configured to mesh with the teeth of the dose counter, the actuator being configured to follow the perimeter of the dose counter when the second body structure is rotated relative to the first body structure, anda rotator configured to rotate concurrently with one of the first body structure and the second body structure, the rotator being configured to engage with the actuator when rotation of the first body structure relative to the second body structure is initiated, causing the actuator to rotate about its central ...

CARTRIDGE FOR AN AEROSOL DELIVERY SYSTEM

A cartridge for an aerosol delivery system. The cartridge includes a fluid reservoir including a first reservoir portion, a second reservoir portion, and at least one liquid barrier configured to separate the first and second reservoir portions. The first and second reservoir portions have respective first and second openings at a first end of the cartridge. The cartridge further includes a perforate membrane located at the first end of the cartridge and over the first and second openings. The first and second openings are configured to supply first and second liquids to a first side of the perforate membrane during use and the perforate membrane comprises a plurality of apertures configured to eject one or both of the first and second liquids from a second side of the perforate membrane in the form of liquid droplets when the perforate membrane is vibrated. An aerosol delivery system includes the cartridge. 1. A cartridge for an aerosol delivery system , the cartridge comprising:a fluid reservoir including a first reservoir portion for containing a first liquid, a second reservoir portion for containing a second liquid, and at least one liquid barrier configured to separate the first and second reservoir portions, wherein the first and second reservoir portions have respective first and second openings at a first end of the cartridge; anda perforate membrane located at the first end of the cartridge and extending over both of the first and second openings such that a first side of the perforate membrane is in fluid communication with the first and second openings, the first and second openings being configured to supply first and second liquids to the perforate membrane during use, the perforate membrane comprising a plurality of apertures configured to eject one or both of the first and second liquids from a second side of the perforate membrane in the form of liquid droplets when the perforate membrane is vibrated during use.2. The cartridge according to claim 1 ...

Electronic cigarette power supply portion

Aspects of the instant disclosure relate to electronic cigarettes; more particularly, to electronic cigarettes including a power supply portion. In various embodiments, the eCig power supply portion includes a sub-assembly housing substantially containing a battery, an airflow sensor, and controller circuitry. Aspects of the disclosure are further directed to an eCig power supply portion further including a hemicylindrical port and/or electrical contacts aligned along a longitudinal axis of the power supply portion.

Aerosol Generating Device Having Vapour-Cooling Passageway

There is provided an aerosol generating device, comprising an inhalation outlet; a chamber for holding a material, the material capable of generating a vapour when heated; a heater for heating material held in the chamber; an air inlet connected by an air inlet passage to the chamber; a vapour-cooling module providing a fluidic connection between the chamber and inhalation outlet, the module configured to cool a vapour passing there through. In use, suction at the inhalation outlet causes air to enter the chamber via the air inlet, thereby transporting the vapour generated in the chamber through the vapour-cooling module to the inhalation outlet, such that the temperature of the vapour exiting the device through the inhalation outlet is substantially lower than the temperature of the vapour generated in the chamber. The aerosol generating device thereby provides a means whereby a vapour generated in the chamber is substantially cooled during transport from the chamber through the mouthpiece to the user. 1. An aerosol generating device , comprising:a body having chamber for holding a material, the material capable of generating a vapour when heated;a heater for heating the material held in the chamber; anda vapour-cooling module having a vapour-cooling passageway including a first portion and a second portion, the vapour-cooling module including:a cap defining an inhalation outlet;a connecting member defining a first portion of the vapour-cooling passageway; andan internal back plate arranged within the cap defining an aperture, the internal back plate and the cap collectively defining the second portion of the vapour-cooling passageway, the aperture providing a fluid connection between the first portion of the vapour-cooling passageway and the second portion of the vapour-cooling passageway,wherein the vapour-cooling passageway has a length arranged to reduce a temperature of the vapour as the vapour is transported through the vapour-cooling passageway from the ...

INHALER

An insert which can be inserted into an inhaler, particularly for a horse has a reservoir for a medicament preparation held under excess pressure and a valve. The insert also has a nebulizer that is held directly on the reservoir and a discharge nozzle, associated with the nebulizer and fluidically connected to the valve, for forming an aerosol with the medicament preparation. 115-. (canceled)16. An insert that is insertable into an inhaler , comprising:a reservoir for a medicament preparation held under excess pressure,a valve, anda nebulizer held directly on the reservoir, and having a discharge nozzle associated therewith and fluidically connected to the valve, for forming an aerosol with the medicament preparation.17. The insert according to claim 16 , wherein the nebulizer is inseparably held on the reservoir.18. The insert according to claim 16 , wherein the discharge nozzle is held in at least one of axially movable and inseparable manner on the reservoir by means of the nebulizer.19. The insert according to claim 16 , further comprising a counter which is driven by initiating dispensing of a medicament preparation.20. The insert according to claim 16 , further comprising a blocking device which is configured to at least one of prevent accidental initiation claim 16 , initiation prior to insertion of the insert into an inhaler claim 16 , and initiation after a predetermined number of initiation processes has been reached or exceeded.21. The insert according to claim 16 , further comprising an orientation device which allows at least one of insertion into the inhaler and initiation of the dispensing of the medicament preparation only in a specified position or orientation of the insert or nebulizer claim 16 , making it possible to fix a direction of discharge of the discharge nozzle.22. The insert according to claim 16 , wherein the insert is configured to dispense the medicament preparation in a direction of discharge which at least one of corresponds at ...

PHARMACEUTICAL DISPENSER WITH A DETECTION DEVICE

A pharmaceutical dispenser with a housing, a medium reservoir, a discharge opening, connection channel connecting the medium reservoir to the discharge opening, and a detection device arranged in the area of the connection channel and designed to detect medium flowing therein. The connection channel is connected to and communicates with a pressure chamber, the detection device includes a membrane which delimits the pressure chamber, and includes an electrically conductive connection portion and is subjected to pressure. The detection device has an electrical mating contact surface in relation to which a membrane-side connection portion is movable when subjected to pressure, such that an electrical contact between the conductive connection portion and the mating contact surface is established or cancelled. 2. The pharmaceutical dispenser as claimed in claim 1 , further includingan electronic evaluating device in the form of an electronic counter, which is provided with two signal lines, the connection of which or the disconnection of which from the evaluating device performs an evaluating or counting process.3. The pharmaceutical dispenser as claimed in claim 2 ,wherein are connected to the two signal lines of the electronic evaluating device,', 'are arranged to be fixed in relation to one another and', 'are capable of being connected to one another or disconnected from one another by the deflection of the membrane-side electrically conductive connecting portion., 'the detection device exhibits two electrical mating contact surfaces which'}4. The pharmaceutical dispenser as claimed in claim 2 , 'the electrical mating contact surface is connected to one of the signal lines and the membrane-side connecting portion is permanently connected to the other signal line.', 'wherein'}5. The pharmaceutical dispenser as claimed in claim 1 , [ a plastic layer and', 'an electrically conductive connecting layer which forms the conductive connecting portion, or, 'the membrane is ...

INHALER MOUTHPIECE

An improved metered dose inhaler may be provided. The improved inhaler may have a mouthpiece designed for improved medicine delivery. The mouthpiece may extend from a cap of the inhaler, which may be removable or molded to the body of the inhaler. 1. An improved metered dose inhaler comprising:an inhaler body;a cap; anda mouthpiece attached to the cap, wherein the mouthpiece is a hollow protrusion extending from the cap, and wherein the cap is removable from the inhaler body or integrally molded as part of the inhaler body.2. The inhaler of claim 1 , wherein the mouthpiece is between 20 mm and 30 mm long.3. The inhaler of claim 1 , wherein the cap is configured to fit the inhaling outlet of spacers.4. The inhaler of claim 1 , wherein the mouthpiece has one of a circular claim 1 , elliptical claim 1 , oblong claim 1 , rectangular claim 1 , or square cross-section.5. The inhaler of claim 1 , wherein the diameter of the mouthpiece is between 5 mm and 10 mm.6. The inhaler of claim 1 , wherein the mouthpiece is configured to fit within a user's mouth and deliver a precise flow of medicine in the user's normal breathing flow without leaking from the user's lips.7. The inhaler of claim 1 , wherein the mouthpiece is slidable in relation to the cap claim 1 , such that the mouthpiece can retract or extend further from the cap. This application claims priority under 35 U.S.C. §119 to Indian Patent Application No. 2676/MUM/2015 filed Jul. 15, 2015, titled An Improved Metered Dose Inhaler And Spacers For Such Inhalers, the disclosure of which is incorporated by reference herein in its entirety.This invention relates to an inhaler, particularly to an improved metered dose inhaler and spacers for such Inhalers.I (the applicant) had been a smoker for many years, due to which I suffer from COPD (chronic obstructive pulmonary disease).Around the world a large number of people suffer from various respiratory diseases, such as Asthma, Chronic Bronchitis, Emphysema etc.A majority of ...

SPACER CHAMBER

The present invention refers to a single piece spacer chamber, a base end and a tip end, the base end having a diameter larger than a diameter of the tip end, single piece chamber is made entirely of a flexible material. A medication container is connected to the tip end. The chamber has a truncated cone shape, a plurality of external zigzag popoid folds circumferentially formed through the external side of the chamber, and a plurality of internal folds circumferentially formed through the internal side of the chamber. The popoid folds have a size that decreases from the base end to the tip end. In a collapsed position each popoid folds against an adjacent popoid and fits entirely inside the adjacent popoid. 1. A spacer chamber for administering a therapeutic agent spray comprising:{'b': 1', '3', '2', '4, 'a one piece body having a base end , a tip end , and a popoid section ,'}{'b': '1', 'wherein the one piece body is made entirely of a flexible material and has a shape of a cone;'}{'b': 3', '1', '3', '2', '1', '2, 'wherein a diameter . of the base end is larger than a diameter . of the tip end ;'}{'b': 4', '4', '1', '4', '1', '4', '2', '4', '3', '4', '4', '1, 'wherein the popoid section includes a plurality of popoids ., each popoid . includes a first set of frustoconical portions . facing opposite to a second set of frustoconical portions . to form a corrugation . in the body ;'}{'b': 4', '2', '4', '3', '4', '1', '3', '4', '2', '4', '3', '4', '1', '2, 'wherein the first and second set of frustoconical portions ., . of the popoid . near to the base end have a greater diameter than the diameter of the first and second set of frustoconical portions ., . of the popoid . near to the tip end ; and'}{'b': 2', '2', '4', '3', '4', '2', '4', '3', '4', '1', '4', '1', '2', '4', '1', '1, 'wherein when the tip end moves toward the base end , the frustoconical portions . maintain their shape, while the frustoconical portions . become inverted to fit within the associated ...

Dual Chamber Nebulizer Apparatus

A dual chamber nebulizer apparatus for atomizing and administering a first and second liquid medicine includes a housing having first and second chambers for holding the first and second liquid medicines. An atomizer member is situated in the housing and configured to atomize liquid into vapor. An air flow member is coupled to the housing and in fluid communication with the atomizer, the flow member having an inlet port for receiving a compressed air flow to the atomizer member. First and second aspiration tubes are in communication with the atomizer member and extend into first and second chambers, respectively. The atomizer member includes a junction in communication with the first and second aspiration tubes, the valve selectively allowing both of the liquid medicines to be drawn through respective aspiration tubes and directed to the atomizer member when the compressed airflow is directed to the atomizer member.

METHODS AND SYSTEMS FOR SUPPLYING AEROSOLIZATION DEVICES WITH LIQUID MEDICAMENTS

A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler. 1. A method for supplying a metered amount of a liquid medicament to an aerosolizing device , the method comprising:providing an aerosolization device comprising a housing having a mouthpiece, a vibratable member within the housing and disposed to eject liquid droplets through the mouthpiece, a reservoir to hold the liquid medicament until aerosolized by the vibratable member, and an opening in the housing that is in fluid communication with the chamber;providing a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed, wherein the dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed;inserting the tip into the opening in the housing;compressing the dispenser body, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the chamber each time the dispenser body is compressed.2. A method as in claim 1 , wherein compressing the ...

Electronic vaporizer

An electronic vaporizer for generating an aerosol includes a housing to be installed to an electronic device by being coupled to the electronic device through a connecting interface of the electronic device, and including: a connecting interface that receives power from a battery included in the electronic device when coupled to the connecting interface of the electronic device, a liquid storage for storing a liquid aerosol generating material and supplying the liquid aerosol generating material to a wick when the housing is disposed in a predetermined posture, an atomizer that includes a wick and a heater for generating an aerosol by heating the liquid aerosol generating material supplied to the wick, and a control circuit that controls heating of the heater for generating the aerosol, based on the power supplied from the battery.

TIDAL INHALER ADAPTIVE DOSING

A dry powder inhaler consisting of a first chamber having an orifice for holding a dry powder and a gas, and a second chamber directly connected to the first chamber by at least one passageway for receiving an aerosolized form of the dry powder from in the first chamber and delivering the aerosolized dry powder to a user. A pressure sensor monitors the pressure in the second chamber. A vibrator coupled to the first chamber aerosolizes the dry powder and cause the aerosolized powder to move through the passageway whereby to deliver the dry powder from the first chamber to the second chamber as an aerosolized dry powder. A vibrator control unit controls operation of the vibrator based on the monitored pressure in the second chamber and a dosing scheme in which the dosing time is determined by the volume of each inhalation. 1. A dry powder inhaler , the dry powder inhaler comprising:a first chamber configured to hold a dry powder and a gas;a second chamber directly connected to the first chamber by at least one passageway configured to receive an aerosolized form of the dry powder from the first chamber and delivering the aerosolized dry powder to a user;a sensor configured to monitor pressure in the second chamber;a vibrator coupled to the first chamber configured to aerosolize the dry powder and cause the aerosolized powder to move through the passageway whereby to deliver the dry powder from the first chamber to the second chamber as an aerosolized dry powder; anda vibrator control unit configured to control operation of the vibrator based on the monitored pressure in the second chamber and a predetermined dosing shot volume.2. The inhaler of claim 1 , wherein the vibrator control unit is further configured to:determine the user's breath cycle and inhalation volume based on the monitored pressure in the second chamber.3. The inhaler of claim 2 , wherein the vibrator control unit is further configured to:activate the vibrator for a series of delivery shots during ...

Dry Powder Inhaler

A dry powder inhaler for at least two capsules containing dry powder is provided, the dry powder inhaler including: At least two capsule chambers each capsule chamber for receiving one of the capsules; a mouth piece with a mouth portion comprising a distal opening; and a duct structure between the distal opening of the mouth piece and the at least two capsule chambers, wherein the duct structure comprises at least two primary ducts, wherein the distal opening of the mouth piece leads into the at least two primary ducts, and wherein each one of the at least two primary ducts leads into the corresponding one of the at least two capsule chambers. 1. A dry powder inhaler for at least two capsules containing dry powder , the dry powder inhaler comprising:at least two capsule chambers each capsule chamber for receiving one of the capsules;a mouth piece with a mouth portion comprising a distal opening and a main body, which comprises a duct structure; andthe duct structure of the mouth piece arranged between the distal opening of the mouth piece and the at least two capsule chambers, wherein the duct structure comprises at least two primary ducts, wherein the distal opening of the mouth piece leads into the at least two primary ducts, and wherein each one of the at least two primary ducts leads into the corresponding one of the at least two capsule chambers.2. The dry powder inhaler according to claim 1 , wherein the duct structure is Y-shaped claim 1 , and wherein the duct structure comprises a secondary duct between the distal opening of the mouth piece and the at least two primary ducts.3. The dry powder inhaler according to claim 2 , wherein the secondary duct comprises a secondary cross-sectional area claim 2 , which equals or is less than a sum of primary cross-sectional areas of the at least two primary ducts.4. The dry powder inhaler according to claim 2 , wherein the length of the secondary duct is equal or greater than the length of one of the primary ducts.5. ...

LOW FLOW ADAPTOR TO DELIVER AEROSOLS VIA NASAL CANNULA WITHOUT CRASHOUT

Device and method of use are described in which a housing is configured and coupled to an aerosol generator which delivers aerosol into an oxygen stream transporting both to a patient via a nasal cannula, in a way to minimize condensation at low liters per minute flow rate. 1. A device for delivery of aerosol along with supplemental oxygen from an oxygen supply to the nasal cannula of a patient , the device comprising:a. a housing, wherein the housing includes a base and a cylindrical wall, wherein the base and the cylindrical wall define a chamber through which supplemental oxygen is led, andb. two couplers, wherein the first of the two couplers is an inlet for supplemental oxygen supply into the chamber, wherein the second of the two couplers is an outlet for delivery of the supplemental oxygen supply containing an aerosol, wherein each of the two couplers is configured to engage a nasal cannula line,wherein chamber wall is configured to snugly fit to an aerosol delivery portion of a nebulizer, wherein the aerosol delivery portion of nebulizer is not positioned to act as a baffle to air flow between the two couplers, wherein there is no baffle or impediment to air flow and aerosol through adaptor,wherein the housing and couplers are designed to facilitate laminar flow.2. The device of wherein the adaptor including housing claim 1 , base claim 1 , cylindrical wall claim 1 , and two couplers are integrally formed.3. The device of wherein the adaptor is formed using a 3D printer.4. The device of wherein each of the two couplers defines a conduit which includes a cylindrical portion along the length of a portion of the coupler.5. The device of wherein each of the two couplers defines a slightly larger cylindrical portion which starts at an abutment of the coupler and continues to the chamber.6. The device of wherein each of the two couplers also defines void which is generally shaped as an end of an ellipsoid.7. The device of wherein each void starts in the slightly ...

DOSE DELIVERY DEVICE FOR INHALATION

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose. 1. A dose delivery device for dispersing and delivering a dose , comprising:a housing containing a dose dispersible in an air flow, the housing defining a chamber in which the dose is located and having a piercable material; and a distal end arranged to puncture the housing at the piercable material with movement of the plunger toward the housing such that the distal end is extended into the chamber,', 'an inlet arranged to direct air from outside the housing into the chamber with the distal end positioned in the chamber, the inlet arranged to create a circulating flow in the chamber that circulates in the chamber about the plunger axis,', 'an outlet arranged to receive a flow of dose entrained air from inside the chamber, and', 'an outlet fluid path that extends along the plunger axis and is arranged to receive dose entrained air from the outlet and deliver the dose entrained air toward a mouthpiece., 'a plunger for accessing the chamber and delivering dispersed dose in an air flow to a mouthpiece, the plunger extending along an axis and including2. The device of claim 1 , wherein the inlet includes a plurality of inlet channels arranged to create the circulating flow of air in the chamber.3. The device of claim 1 , wherein the outlet includes a ...

INHALER

An inhaler for delivery of a medicament by inhalation is disclosed. The inhaler comprises a dose counting mechanism comprising a counter. The inhaler further comprises a dispensing mechanism, the dispensing mechanism being configured, on actuation, to dispense a dose of medicament and to adjust the counter. The inhaler further comprises a resetting member configured for movement in a first direction between a first position and a second position to reset the dispensing mechanism, and a prevention mechanism comprising a pair of first and second engaging members. If the movement of the resetting member in the first direction is reversed before it reaches the second position, the first and second engaging members prevent further actuation of the dispensing mechanism until the resetting member is again moved in the first direction. At least one of the first and second engaging members is configured to resiliently flex, under load, into abutment with a substantially rigid component of the inhaler. Preferably the dose counting mechanism counter indicates the number of remaining doses in, or the number of dispensed doses from, the inhaler. 1. An inhaler for delivery of a medicament by inhalation , comprising:a dose counting mechanism including a counter;a dispensing mechanism that is configured, when actuated, to dispense a dose of medicament and to adjust the counter of the dose counting mechanism, wherein the dispensing mechanism includes a loading member;a resetting member configured for movement in a first direction from a first position to a second position to load the loading member and reset the dispensing mechanism; anda prevention mechanism including at least a first engaging member and a second engaging member, wherein the first engaging member is configured to engage in a mating configuration with the second engaging member,wherein:when movement of the resetting member in the first direction is interrupted before the resetting member reaches the second position, ...

DRY POWDER INHALER FOR DELIVERING MULTIPE AGGLOMERATE FORMULATIONS

Various embodiments provide drug products and dry powder inhalers. With various embodiments of the present invention, a de-agglomeration chamber and by-pass channel are provided which allow for various de-agglomerating capabilities for dry powder dispensers. 1. A dry powder inhaler for dispensing inhaled doses of dry powder , the dry powder inhaler comprising:a de-agglomeration chamber having at least one exit opening, a first inlet opening and a second inlet opening, said at least one exit opening, said first inlet opening and said second inlet opening being arranged such that, upon inhalation of a dose, negative pressure is applied to said at least one exit opening which causes a first stream of dry powder to be entrained from said first inlet opening into said de-agglomeration chamber directed toward said at least one exit opening, said negative pressure also causing a second stream of dry powder to be entrained from said second inlet opening into said de-agglomeration chamber directed toward said at least one exit opening, said first and second streams of dry powder colliding in said de-agglomeration chamber to form a collective stream passing through said exit opening; and,at least one by-pass channel disposed adjacent to, and separated from, said de-agglomeration chamber, said at least one by-pass channel having an inlet and an outlet, wherein, upon inhalation of a dose, negative pressure is applied to said outlet which causes a third stream of dry powder to be entrained from said inlet directed toward said outlet, said third stream of dry powder not passing through any portion of said de-agglomeration chamber.2. A dry powder inhaler as in further comprising a swirl nozzle having an opening in communication with said outlet of said by-pass channel.3. A dry powder inhaler as in claim 2 , wherein said at least one exit opening of said de-agglomeration chamber is in communication with said opening of said swirl nozzle.4. A dry powder inhaler as in further ...

Method to Deliver Medication

A method to deliver medication. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and variable-volume chamber with an acoustic source and measures the acoustic response with microphones acoustically coupled to the reference and the variable-volume chamber. A disposable drug cassette is coupled to the acoustic volume sensor and includes a drug reservoir and valve. The method includes receiving a volume signal and inputs from a user input or a second sensor and controlling the valve based on these inputs.

INHALER SPACER AND STORAGE APPARATUS

A spacer may improve the effectiveness of medication delivery by an inhaler. The spacer may be configured to store the inhaler to improve compactness and/or portability of the spacer and inhaler. The inhaler may be coupled to a retaining device, inhaler container, and/or the like that restricts movement of the inhaler to predetermined positions and/or orientations. A user may be able to transition the inhaler between a stored position and an active position by moving the inhaler translationally and/or rotationally. The inhaler may be able to remain coupled to the retaining device and/or inhaler container, and the retaining device and/or inhaler container may be able to remain coupled to the spacer during transition from the stored position to the active position. The spacer may be sized to fit in a pants pocket in an embodiment. 1. A spacer apparatus to slow the delivery of medication released from an inhaler , the spacer apparatus comprising:a spacer housing defining a spacer chamber; anda retaining device configured to receive the inhaler, wherein the retaining device is rotatably coupled to the spacer housing, andwherein the retaining device is configured to shift the inhaler from a stored position in which the inhaler is completely contained in the spacer housing to an active position in which the inhaler is able to deliver the medication to the spacer chamber.2. The spacer apparatus of claim 1 , wherein the retaining device rotates about a pivot point claim 1 , and wherein the pivot point is located in the spacer housing.3. The spacer apparatus of claim 2 , wherein the pivot point is configured to move relative to the spacer housing.4. The spacer apparatus of claim 1 , wherein the spacer housing includes a concave wall configured to reflect received medication into the spacer chamber.5. The spacer apparatus of claim 1 , wherein the inhaler protrudes from the spacer housing in the active position.6. The spacer apparatus of claim 1 , wherein the spacer housing ...