07-01-2016 дата публикации
Номер: US20160000790A1
The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist. 1. A composition which comprises (a) a PDE3/PDE4 inhibitor which is 9 ,10-Dimethoxy-2-(2 ,4 ,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3 ,4 ,6 ,7-tetrahydro-2H-pyrimido[6 ,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.2. A composition according to claim 1 , in which the PDE3/PDE4 inhibitor (a) is 9 claim 1 ,10-Dimethoxy-2-(2 claim 1 ,4 claim 1 ,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3 claim 1 ,4 claim 1 ,6 claim 1 ,7-tetrahydro-2H-pyrimido[6 claim 1 ,1-a]isoquinolin-4-one.3. A composition according to claim 1 , in which the muscarinic receptor antagonist (b) is atropine claim 1 , hyoscine claim 1 , glycopyrrolate claim 1 , ipratropium claim 1 , tiotropium claim 1 , oxitropium claim 1 , pirenzepine claim 1 , telenzepine claim 1 , aclidinium or umeclidinium.4. A composition according to claim 1 , in which the muscarinic receptor antagonist (b) is atropine claim 1 , ipratropium bromide or tiotropium bromide.5. A composition according to claim 1 , wherein the composition is a fixed combination.6. A pharmaceutical composition comprising a composition as defined in and one or more pharmaceutically acceptable carriers claim 1 , diluents claim 1 , or excipients.7. A pharmaceutical composition according to which is for administration by dry powder inhaler (DPI) or metered-dose inhaler (MDI).8. A method of treating a disease or condition which is based on (i) acute or chronic obstruction of vessels or bronchi or (ii) acute or chronic inflammation claim 6 , in a subject in need thereof claim 6 , which method comprises administering to said subject (a) a PDE3/PDE4 ...
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