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Применить Всего найдено 13712. Отображено 200.
14-12-2023 дата публикации

УСТРОЙСТВА ДЛЯ ИНТРАНАЗАЛЬНОЙ ДОСТАВКИ

Номер: RU2809679C2

Группа изобретений относится к медицинской технике, а именно, к устройству для интраназальной доставки и способам его применения и изготовления. Устройство содержит сопло, имеющее резервуар, расположенный внутри сопла. Устройство включает проходной клапан, вставленный в резервуар. Устройство имеет фиксатор, который является полым и выполнен с возможностью удержания проходного клапана. Устройство содержит ручной воздушный насос, имеющий рабочее соединение с входным концом сопла и выходным концом фиксатора. Проходной клапан имеет зону контакта с фиксатором и неподвижен при приведении в действие ручного насоса. Резервуар содержит размещенный в нем порошковый лекарственный препарат. Фиксатор содержит желоб, выполненный с возможностью улавливания порошкового лекарственного препарата, упавшего из сопла. Согласно способу использования помещают сопло устройства в ноздрю субъекта, и приводят в действие ручной воздушный насос. Сопло содержит порошковый лекарственный препарат. Способ изготовления ...

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20-01-2016 дата публикации

СПОСОБ ИЗГОТОВЛЕНИЯ УСТРОЙСТВА ДЛЯ ДОЗИРОВАНИЯ ЛЕКАРСТВА

Номер: RU2572909C2
Принадлежит: ПОРТАЛ МЕДИКАЛ ЛТД (GB)

Изобретение относится к способу изготовления устройства для дозирования лекарства. Способ обработки компонента устройства для дозирования лекарства имеет по меньшей мере одну поверхность, входящую в контакт с лекарством в процессе хранения или применения устройства,и включает следующие этапы: получение указанного компонента и покрытие по меньшей мере одной из поверхностей методом плазменного осаждения для снижения осаждения лекарства на поверхность или разрушения лекарства, при котором по меньшей мере часть процесса плазменного осаждения осуществляют под контролем смещения постоянным током при фиксированном постоянном токе смещения для поддержания постоянной эмиссии электронов и постоянной плотности плазмы, причем на этапе плазменного осаждения компонент заземляют. Способ изготовления устройства для дозирования лекарства включает обработку компонента устройства способом, приведенным выше, получение других компонентов устройства и сборку компонентов. Технический результат: повышение эксплуатационных ...

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10-11-2023 дата публикации

ИНГАЛЯЦИОННОЕ УСТРОЙСТВО И СПОСОБ ЕГО ИСПОЛЬЗОВАНИЯ

Номер: RU2807165C2
Принадлежит: инвоКС Белджиум НВ (BE)

Группа изобретений относится к медицинской технике, а именно к портативному ингаляционному устройству для подачи распыляемого аэрозоля медицинского назначения для ингаляционной терапии и способу образования распыляемого аэрозоля жидкости (F) медицинского назначения. Устройство содержит (a) корпус (1), имеющий обращенную к пользователю сторону. Устройство включает (b) сопло (6) ударного типа для образования распыляемого аэрозоля посредством столкновения по меньшей мере двух потоков жидкости. Сопло (6) является прикрепленным к обращенной к пользователю стороне корпуса (1) таким образом, что оно является неподвижным относительно корпуса (1). Устройство имеет (c) резервуар (2) для текучей среды, размещенный внутри корпуса (1). Устройство содержит (d) нагнетательный блок, размещенный внутри корпуса (1). Нагнетательный блок имеет расположенный раньше по ходу текучей среды конец, который сообщается посредством текучей среды с резервуаром (2) для текучей среды. Нагнетательный блок включает расположенный ...

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10-11-2008 дата публикации

НАЗАЛЬНЫЕ УСТРОЙСТВА (ВАРИАНТЫ)

Номер: RU2337720C2
Принадлежит: ОПТИНОУЗ АС (NO)

Изобретение относится к медицине. Устройство содержит наконечник для размещения в ноздре пациента, блок подачи вещества, предназначенный для подачи вещества, подлежащего доставке, через наконечник, и механизм предотвращения доставки вещества через наконечник до тех пор, пока наконечник не будет правильно размещен в ноздре пациента. Варианты устройства отличаются выполнением средств, предотвращающих доставку. Решена задача обеспечения доставки при правильном размещении в ноздре пациента. 3 н. и 37 з.п. ф-лы, 13 ил.

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20-04-2015 дата публикации

БЕСКОНСЕРВАНТНЫЕ СОСТАВЫ, СОДЕРЖАЩИЕ ИНСУЛИН, И СИСТЕМЫ И СПОСОБЫ ДЛЯ ПЕРЕВОДА В АЭРОЗОЛЬНОЕ СОСТОЯНИЕ

Номер: RU2548755C2

Изобретение относится к фармацевтической промышленности и представляет собой состав специально адаптированный для перевода инсулина в аэрозольное состояние, содержащий от 100 IU/мл до 1200 IU/мл инсулина в водеи от 2 до 4 Znионов на гексамер инсулина, где состав является бесконсервантным и где состав способен переходить в аэрозольное состояние в качестве спрей-аэрозоля при использовании вибрирующей пластины с отверстием, без существенного вспенивания состава, когда состав удерживается на задней поверхности пластины с отверстием за счет гравитации и спрей выбрасывается с передней поверхности пластины с отверстием исключительно за счет вибрации пластины с отверстием. Изобретение обеспечивает снижение вспенивания состава, уменьшение время перевода в аэрозольное состояние и увеличение эффективности введения дозы инсулина. 4 н. и 15 з.п. ф-лы, 5 ил.

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19-12-2017 дата публикации

АРОМАТИЧЕСКИЙ ИНГАЛЯТОР НЕГОРЯЩЕГО ТИПА

Номер: RU2639081C2

Настоящее изобретение относится к ароматическому ингалятору негорящего типа. Предложен ароматический ингалятор негорящего типа, подающий аэрозоль, распыляемый с помощью распылителя без горения, причем ингалятор содержит светоизлучающий элемент и блок управления, который управляет светоизлучающим элементом, при этом упомянутый блок управления управляет светоизлучающим элементом в заданном светоизлучающем режиме в состоянии отсутствия затяжки, когда аэрозоль не вдыхается, заданный светоизлучающий режим включает в себя первый заданный светоизлучающий режим и второй заданный светоизлучающий режим, причем первый заданный светоизлучающий режим сохраняется до тех пор, пока число затяжек не достигнет определенного числа, которое составляет два или более, второй заданный светоизлучающий режим применяется после того, как число затяжек превысит это определенное число, первый заданный светоизлучающий режим отличается от второго заданного светоизлучающего режима, и упомянутое определенное число, которое ...

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24-05-2018 дата публикации

Производные 1-фенил-2-пиридинилалкиловых спиртов в качестве ингибиторов фосфодиэстеразы

Номер: RU2655170C2

Изобретение относится к соединению общей формулы (I), его N-оксидам по пиридиновому кольцу и их фармацевтически приемлемым солям:, где: Rи Rявляются разными или одинаковыми и независимо выбраны из группы, состоящей из: линейного (С-С)-алкила, возможно замещенного одним заместителем, выбранным из (С-С)-циклоалкила; (С-С)-галогеналкила; (С-С)-циклоалкила; Rпредставляет собой Н или представляет собой один или два заместителя, независимо выбранных из атомов галогена; Z представляет собой группу (СН), где m равно 0; А представляет собой фенильное кольцо, возможно замещенное одним заместителем R, который выбран из группы, состоящей из: линейного (С-С)-алкила, замещенного одним морфолинилом; разветвленного (С-С)-алкила, возможно замещенного одним (С-С)-циклоалкилом; (С-С)-галогеналкила; (С-С)-алкилтио; атома галогена; и OR, где Rвыбран из группы, состоящей из Н; (С-С)-алкила, возможно замещенного радикалом, выбранным из (С-С)-циклоалкила, морфолинила, фенила и пиридинила; и (С-С)-алкила, замещенного ...

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14-12-2020 дата публикации

СИСТЕМЫ ДОСТАВКИ АЭРОЗОЛЯ И СООТВЕТСТВУЮЩИЕ СПОСОБЫ

Номер: RU2738578C2

Изобретение относится к медицинской технике, а именно к блоку (10, 210, 410) доставки аэрозоля для селективной доставки дозы аэрозолированного вещества. Блок содержит основной корпус (12, 212, 412) и узел (260) исполнительного механизма, имеющийся в основном корпусе (12, 212, 412). Блок включает узел (14, 214, 414) съемного картриджа, соединенный с основным корпусом (12, 212, 412) и взаимодействующий с узлом (260) исполнительного механизма. Узел (14, 214, 414) съемного картриджа включает в себя контейнер (16, 216, 416), содержащий вещество, подлежащее аэрозолизации; и блок картриджа, в который загружается контейнер (16, 216, 416). Блок картриджа включает в себя тело (90, 290, 430) картриджа, имеющее отверстие (92, 292, 432) мундштука, через которое осуществляется вдыхание дозы аэрозолированного вещества, высвобождаемого из контейнера (16, 216, 416), по меньшей мере одно впускное отверстие (94, 294, 436), через которое может поступать воздух в блок картриджа, и ингаляционный проход (96, ...

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27-12-2016 дата публикации

ВВЕДЕНИЕ ИЛОПРОСТА В ВИДЕ АЭРОЗОЛЬНЫХ БОЛЮСОВ

Номер: RU2605849C2
Принадлежит: ФЕКТУРА ГМБХ (DE)

Данное изобретение относится к новому способу, композиции и набору, применимым для лечения легочных заболеваний, таких как легочная артериальная гипертензия. В частности, предусмотрены композиции илопроста, которые могут быть аэрозолированы, которые предназначены для применения в ингаляционной терапии. Их введение представляет собой болюсную ингаляцию, которая является удобной для пациента, эффективной и хорошо переносимой. Болюсная ингаляция может, например, быть достигнута с использованием эффективного небулайзера, основанного на технологии вибрирующей сетки. 3 н. и 15 з.п. ф-лы, 4 ил., 4 пр.

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10-07-2005 дата публикации

СПОСОБ И УСТРОЙСТВО ДЛЯ УСИЛЕНИЯ СЕРДЕЧНОЙ ФУНКЦИИ

Номер: RU2255767C2

Изобретение относится к кардиохирургии. Размерные характеристики сердца циклически изменяются зацеплением мостика, по меньшей мере, между двумя точками на миокарде сердца и циклическим изменением длины мостика. Это регулирует промежуток между зацепленными частями миокарда, улучшая посредством этого сердечную функцию. Мостик может проходить через полость левого желудочка или между точками, разделенными промежутком, вокруг полости левого желудочка. Технический результат заключается в низкотравматическом обеспечении усиления сердечной функции. 5 н. и 16 з.п. ф-лы, 30 ил.

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07-11-2019 дата публикации

КОНТЕЙНЕР ДЛЯ ОБРАЗУЮЩИХ АЭРОЗОЛЬ УСТРОЙСТВ

Номер: RU2705479C2

Изобретение относится к контейнеру для образующего аэрозоль устройства и к образующему аэрозоль устройству. Контейнер для образующего аэрозоль устройства содержит первое отделение, которое герметизировано, является трубчатым и содержит источник никотина; второе отделение, которое герметизировано, является трубчатым и содержит соединение для улучшения доставки; и передаточную секцию, расположенную между первым отделением и вторым отделением, причем первое отделение и второе отделение образованы из слоистого материала, содержащего по меньшей мере один слой картонного материала и по меньшей мере один слой полимерного материала, и указанный слой полимерного материала образует внутреннюю поверхность первого отделения и второго отделения. Техническими результатами изобретения являются создание изделия для использования в образующем аэрозоль устройстве, имеющего более низкую стоимость и сложность по сравнению с изделием, имеющим алюминиевые емкости, без значительного снижения улучшенной характеристики ...

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27-04-2009 дата публикации

ПОЛОСКА ДЛЯ КОЛПАЧКА ИНГАЛЯТОРА

Номер: RU2353401C2
Принадлежит: АстраЗенека АБ (SE)

Изобретение относится к медицинской технике. Ингалятор для выдачи доз медикамента из контейнера в результате действий пользователя содержит корпус, включающий мундштук, через который выдается медикамент, и колпачок, который может быть установлен по существу в положение закрытия мундштука. Колпачок прикреплен к корпусу полоской, которая поворачивается в сторону от корпуса, и может скользить на полоске так, что его нужно переместить поступательно в сторону от мундштука до выполнения поворота указанной полоски. Изобретение позволяет хранить ингалятор при ориентации, обеспечивающей возможность точного дозирования. 6 з.п. ф-лы, 5 ил.

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11-10-2017 дата публикации

СПОСОБ И СИСТЕМА ДЛЯ ЭЛЕКТРОННОЙ МОДЕЛИ MDI (ДОЗИРУЮЩЕГО ИНГАЛЯТОРА)

Номер: RU2633269C2

Группа изобретений относится к медицинской технике. Способ формирования аэрозольного облака осуществляется с помощью устройства, содержащего емкость дозирующего ингалятора под давлением (MDI), вмещающую раствор препарата лекарственного средства, применяемого с гидрофторалкановыми (HFA) пропеллентами. Емкость ингалятора MDI соединена с электронным клапаном. Клапан выполнен с возможностью получения сигналов управления из микропроцессора. При осуществлении способа в запоминающем устройстве сохраняют набор параметров лекарственного средства, содержащий количественный показатель, указывающий суммарное количество аэрозольного лекарственного средства, подлежащего дозированию во время сеанса введения лекарственного средства; управляют открыванием электронного клапана, обеспечивая дозирование суммарного количества аэрозольного лекарственного средства в течение времени ингаляции путем последовательных малообъемных импульсов. Временной интервал между импульсами составляет между 20 и 50 мс. Объем лекарственного ...

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27-02-2013 дата публикации

ОДНОРАЗОВАЯ АМПУЛА ДЛЯ УСТРОЙСТВА РАСПЫЛЕНИЯ АЭРОЗОЛЯ

Номер: RU2476197C2
Принадлежит: ПАРИ ФАРМА ГМБХ (DE)

Изобретение относится к медицине и фармацевтической промышленности и касается одноразовой ампулы для применения в устройстве распыления аэрозоля. Ампула включает контейнер для лекарственного средства, который содержит лекарственное средство и состоит из корпуса (10) контейнера и дна (11) контейнера, и заданное место (12) излома, которое, по меньшей мере, частично охватывает дно контейнера. Ампула характеризуется наличием манжеты (15), которая окружает заданное место (12) излома на его внешней стороне и продолжает корпус контейнера поверх и за пределы дна (11) контейнера. 2 н. и 17 з.п. ф-лы, 6 ил.

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12-05-2020 дата публикации

Номер: RU2018131232A3
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27-04-2018 дата публикации

Номер: RU2016141826A3
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31-10-2018 дата публикации

Номер: RU2016151794A3
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12-04-2019 дата публикации

Номер: RU2017115845A3
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17-01-2019 дата публикации

Номер: RU2016147888A3
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07-12-2018 дата публикации

Номер: RU2016151789A3
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17-05-2019 дата публикации

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Номер: RU2688020C2
Принадлежит: ДАНС БАЙОФАРМ ИНК. (US)

Изобретение относится к медицинской технике, а именно к самопрокалывающимся картриджам с жидким лекарственным средством и связанному с ними ингалятору, используемым для доставки одной или нескольких отдельно взятых доз переведенного в аэрозольное состояние жидкого лекарственного средства. Самопрокалывающийся картридж содержит: контейнер в сборе, содержащий: контейнер, предназначенный для хранения жидкого лекарственного средства; перегородку, предназначенную для герметизации первого конца контейнера; поршень, герметизирующий второй конец контейнера, причем поршень выполнен с возможностью перемещения относительно контейнера таким образом, чтобы выборочно выталкивать объем жидкого лекарственного средства из контейнера через полую иглу; и иглу в сборе, выполненную с возможностью перехода между первой конфигурацией, в которой полая игла не продолжается через перегородку, и второй конфигурацией, в которой полая игла продолжается через перегородку. При этом игла в сборе содержит: колпачок, выполненный ...

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Номер: RU2489173C2
Принадлежит: АстраЗенека АБ (SE)

Изобретение относится к медицине. Дозатор содержит выпускное отверстие для выдачи лекарственного средства, дисплей для отображения индикационных данных для пользователя, крышку выпускного отверстия, выполненную с возможностью перемещения между первым положением, в котором она закрывает выпускное отверстие, и вторым положением, в котором выпускное отверстие открыто. При нахождении крышки выпускного отверстия в первом положении индикационные данные на дисплее открыты для обзора. При нахождении указанной крышки во втором положении индикационные данные скрыты от пользователя. Технический результат состоит в обеспечении средств для побуждения пользователя к закрытию выпускного отверстия за счет отображения информации только при закрытом отверстии дозатора. 15 з.п. ф-лы, 3 ил.

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Номер: RU2710438C1

Ингаляционные устройства для ингаляции капельного тумана известны из уровня техники. Предлагается ингаляционное устройство (10), которое содержит резервуар (90) для хранения жидкости до ее выведения из него и распылительную головку (14) для выведения (диспенсирования) жидкости в форме капельного тумана (100). Распылительная головка (14) содержит сопловое устройство (56) для генерирования капельного тумана (100). У устройства имеется также наружный корпус (40), на котором закреплен выводящий канал (42) для использования в качестве дыхательной трубки или для прикрепления отдельной дыхательной насадки (70, 72). Главная ось (2) выводящего канала составляет с центральным направлением (4) диспенсирования сопловым устройством (56) угол >0°. На центральном направлении (4) диспенсирования имеется либо отверстие (44), которое выполнено в наружном корпусе (40) распылительной головки (14) и через которое капельный туман (100) может покидать распылительную головку (14), если он не был всосан в выводящий ...

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Номер: RU2005141549A
Принадлежит:

... 1. Аэрозольное средство, содержащее аэрозольную композицию, включающую соединение макролида; и емкость, в которой заключена аэрозольная композиция, включающую клапанную часть, имеющую "уплотнитель", изготовленный по меньшей мере из одного смолистого материала, выбранного из бутилкаучука, этиленпропиленового каучука, хлоропренового каучука, полиэтилена, полибутилентерефталата, полиацеталя, полиамида, политетрафторэтилена, полипропилена и термопластичного эластомера. 2. Аэрозольное средство по п.1, в котором соединение макролида является такролимусом или гидратированным такролимусом. 3. Аэрозольное средство по п.2, в котором содержание такролимуса или гидратированного такролимуса в аэрозольной композиции составляет не более 0,15 мас.%. 4. Аэрозольное средство по любому из пп.1-3, в котором аэрозольная композиция дополнительно содержит сжиженный гидрофторалкан. 5. Аэрозольное средство по п.4, в котором сжиженный гидрофторалкан выбран из группы, состоящей из HFA-134a и HFA-227 или их смеси.

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Номер: RU2010101002A
Принадлежит:

... 1. Ингалятор (1) для активного распыления в виде аэрозоля (14) средств (2) для ингаляции, имеющий транспортирующие средства для транспортировки и(или) распыления средства (2) для ингаляции, в частности, для генерирования аэрозоля (14), и мундштук (13), соединенный или сообщающийся с по меньшей мере одним отверстием (15) для подачи воздуха, отличающийся тем, что он обладает сопротивлением потоку, составляющим по меньшей мере 60000 Па1/2с/м3. ! 2. Ингалятор по п.1, отличающийся тем, что он обладает сопротивлением потоку, составляющим по меньшей мере 75000 Па1/2с/м3, предпочтительно примерно 90000 или 96000 Па1/2с/м3. ! 3. Ингалятор по п.1 или 2, отличающийся тем, что он имеет одно или более отверстий (15) для подачи воздуха, имеющих уменьшенный размер. ! 4. Ингалятор по п.1 или 2, отличающийся тем, что он имеет вставку для установки в мундштук. ! 5. Ингалятор по п.1 или 2, отличающийся тем, что он имеет генератор (5) давления в качестве транспортирующего средства, в частности, с транспортирующим ...

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Номер: RU2015110695A
Принадлежит:

... 1. Ингалятор, содержащий источник пригодной для ингаляции композиции, выпускной канал для потока для композиции от источника до выпускного отверстия для композиции на выпускном конце ингалятора, средство для создания потока композиции от источника по выпускному каналу для потока и из выпускного отверстия для композиции при приложении аспирации к выпускному концу; и два выпускных отверстия для воздуха на выпускном конце, расположенные на противоположных сторонах от выпускного отверстия для композиции, через которое воздух втягивается в соответствующие струи воздуха при приложении аспирации к выпускному концу, при этом выпускные отверстия для композиции и воздуха расположены таким образом, чтобы при использовании две струи воздуха ударяли в шлейф композиции.2. Ингалятор по п. 1, в котором имеются только два выпускных отверстия для воздуха.3. Ингалятор по п. 1, в котором дополнительные отверстия для воздуха присутствуют по меньшей мере в виде одной дополнительной противоположно расположенной ...

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Номер: RU2009115720A
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... 1. Способ перорального введения субъекту жидкости, содержащей активную субстанцию, для улучшенной абсорбции в кровоток субъекта, где способ включает ! предоставление устройства доставки, содержащего жидкость и имеющего наконечник для направления жидкости в определенном направлении во время доставки; ! направление наконечника на ограниченную область полости рта субъекта, особенно подходящую для улучшенного всасывания и более быстрого начала действия активной субстанции в сравнении с другими областями и/или всей полостью рта, и ! доставку дозированного количества жидкости непосредственно к ограниченной области с помощью устройства доставки. ! 2. Способ нанесения капель жидкости или атомизированной жидкости, содержащей активную субстанцию, в полости рта субъекта для улучшенной абсорбции в кровоток субъекта, где способ включает шаги: i) расположения устройства для распыления, содержащего жидкость и имеющего наконечник для распыления жидкости в определенном направлении, ii) направление наконечника ...

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Номер: RU2008147416A
Принадлежит:

... 1. Средство для распыления заданного количества жидкости, содержащее кожух (1) и распылитель (5) для размещения распылительного сосуда (2) в свободном пространстве (3) кожуха (1), ! отличающееся тем, что ! кожух (1) содержит активирующее устройство (7, 8а, 8b), образованное двумя противоположными боковыми поверхностями (7) в виде нажимных поверхностей в нижней части кожуха (1) и, по меньшей мере, одним рычагом (8а, 8b), установленным шарнирно и выполненным интегрально с этими боковыми поверхностями, ! при этом рычаги (8а, 8b) предназначены для поворота ко дну (14) аэрозольного сосуда (2), когда он вставлен в кожух (1) и расположен в свободном пространстве (3), благодаря чему усилия (Р), приложенные в противоположных направлениях к боковым поверхностям (7), преобразуются в осевое перемещение активирующего устройства, которое выталкивает аэрозольный сосуд (2) к распылителю (5), ! кожух (1), распылитель (5) и активирующее устройство (7, 8а, 8b) выполнены интегрально; ! для минимизации остаточного ...

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Номер: RU2009123496A
Принадлежит:

... 1. Аэрозольное устройство, содержащее контейнер с отверстием на одном конце, клапанный узел, поддерживаемый внутри контейнера, и герметизирующее средство для обеспечения герметизации между клапаном и контейнером. ! 2. Аэрозольное устройство по п.1, дополнительно содержащее крышечный элемент для удержания клапанного узла в контейнере, причем крышечный элемент является отдельным от упомянутого уплотняющего средства. ! 3. Аэрозольное устройство по п.2, в котором крышечный элемент крепится к внешней стороне контейнера. ! 4. Аэрозольное устройство по п.2, в котором крышечный элемент спрессовывается с контейнером. ! 5. Аэрозольное устройство по п.3, в котором крышечный элемент спрессовывается с контейнером. ! 6. Аэрозольное устройство по п.2, в котором крышечный элемент и контейнер соединяются посадкой с защелкиванием. ! 7. Аэрозольное устройство по п.3, в котором крышечный элемент и контейнер соединяются посадкой с защелкиванием. ! 8. Аэрозольное устройство по п.3, в котором накладка используется ...

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Номер: RU2014114014A
Принадлежит:

... 1. Кристаллические микрочастицы, состоящие из фенилалкиламинового бета-адренергического агониста, покрытые C12-C20 жирной кислотой в количестве, составляющем от 0,2 до 2,5% масс.2. Кристаллические микрочастицы по п. 1, где бета-агонист выбран из производного, соответствующего общей формуле (I):гдеRпредставляет собой CHOH или NHCOR,при условии, что когда Rпредставляет собой CHOH, Rвсегда представляет собой водород, при этом, когда Rпредставляет собой NHCOR, Rи Rмогут представлять собой независимо водород или вместе образовывать радикал винилен (-CH=CH-) или этокси (-CH-O-);m представляет собой целое число от 0 до 5, предпочтительно 0 или 5;n представляет собой целое число от 0 до 4, предпочтительно 0, 2 или 4;p представляет собой целое число от 0 до 2, предпочтительно 0 или 1;A представляет собой кислород или связь;B представляет собой кислород или связь;Rи Rпредставляют собой водород или метил; или, когда m равен 1, n, p равны 0, A и B представляют собой связи, и Rпредставляет собой водород ...

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Номер: RU2008146167A
Принадлежит:

... 1. Одноразовая ампула для применения в устройстве распыления аэрозоля, содержащая ! контейнер для лекарственного средства, который содержит лекарственное средство и состоит из корпуса (10) контейнера и дна (11) контейнера, и ! заданное место (12) излома, которое, по меньшей мере, частично охватывает дно контейнера, ! отличающаяся тем, что ! содержит манжету (15), которая окружает заданное место излома на его внешней стороне и продолжает корпус контейнера поверх и за пределы дна контейнера. ! 2. Ампула по п.1, в которой манжета (15) расширяется в виде конуса, по меньшей мере, в ее внутреннем профиле, начиная от дна (11) контейнера. ! 3. Ампула по п.1 или 2, в которой корпус контейнера подразделен на две функциональных зоны (20, 21) так, что ампула имеет модульную конструкцию. ! 4. Ампула по п.3, в которой в первой функциональной зоне (21), содержащей дно контейнера, ампула, по меньшей мере, в ее внутреннем профиле проходит в виде конуса в направлении дна (11) контейнера, и вторая функциональная ...

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РАСПЫЛИТЕЛЬНОЕ УСТРОЙСТВО, СПОСОБ РАСПЫЛЕНИЯ ОПРЕДЕЛЕННОГО КОЛИЧЕСТВА ЖИДКОСТИ И СПОСОБ ИЗГОТОВЛЕНИЯ УСТРОЙСТВА

Номер: RU2008105023A
Принадлежит:

... 1. Устройство для распыления определенного количества жидкости, причем устройство содержит кожух (1) и сопло (5) для размещения резервуара (4) с жидкостью и насоса (6) в полости (3) кожуха (1), отличающееся тем, что: ! кожух (1) содержит исполнительный механизм (7, 16, 8а, 8b), который состоит из двух противоположных боковых поверхностей (7), сконструированных как сжимаемые поверхности в нижней части кожуха (1) и по меньшей мере одного шарнирного сцепного рычага (16, 8а, 8b), выполненного как одно целое с этими боковыми поверхностями, ! указанный сцепной рычаг (16, 8а, 8b) предназначен для складывания в направлении основания (14) резервуара (4) с жидкостью, когда он вставлен в кожух (1) и размещен в полости (3), причем усилия Р с противоположной направленностью, приложенные к боковым поверхностям (7) преобразуются в аксиальное перемещение исполнительного механизма, который прижимает насос (6) к соплу (5), и ! кожух (1), сопло (5) и исполнительный механизм (7, 16, 8а, 8b) выполнены как одно ...

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Номер: RU2014101414A
Принадлежит:

... 1. Устройство для промывания носа, предназначенное для подачи промывающей текучей среды пользователю устройства и содержащее механический модуль и резервуарный узел, причем в механическом модуле имеется источник физиологического раствора, содержащий капсулу и расположенный смежно с закрывающим узлом, который выполнен с возможностью открытия капсулы при закрытии крышки для выпуска содержимого капсулы в резервуарный узел.2. Устройство по п. 1, в котором резервуарный узел содержит верхний резервуар и нижний резервуар, выполненные с возможностью выборочного отсоединения.3. Устройство по п. 2, дополнительно содержащее назальный интерфейс, расположенный относительно механического модуля с формированием прохода для текучей среды из верхнего резервуара через механический модуль, через назальный интерфейс и снова через механический модуль в нижний резервуар.4. Устройство по п. 3, в котором механический модуль содержит откачивающий насос и стойку для картриджа, содержащую указанный закрывающий узел ...

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10-02-2016 дата публикации

СПОСОБ И СИСТЕМА ДЛЯ ЭЛЕКТРОННОЙ МОДЕЛИ MDI (ДОЗИРУЮЩЕГО ИНГАЛЯТОРА)

Номер: RU2014120159A
Принадлежит:

... 1. Способ формирования аэрозольного облака, содержащего дозу высокодисперсных частиц лекарственного средства, с помощью устройства, содержащего емкость дозирующего ингалятора под давлением (MDI), вмещающую раствор препарата лекарственного средства, применяемого с HFA-пропеллентами, при этом емкость ингалятора MDI соединена с электронным клапаном и клапан выполнен с возможностью получения сигналов управления из микропроцессора, причем способ содержит следующие этапы:- сопровождают в запоминающем устройстве, по меньшей мере, один набор параметров лекарственного средства, причем каждый набор параметров содержит количественный показатель, указывающий суммарное количество аэрозольного лекарственного средства, подлежащего дозированию во время сеанса введения лекарственного средства;- управляют микропроцессором открыванием электронного клапана, что допускает дозирование суммарного количества аэрозольного лекарственного средства в течение суммарного времени ингаляции путем множества последовательных ...

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20-12-2011 дата публикации

УПАКОВКА ДЛЯ УСТРОЙСТВА РАЗДАЧИ

Номер: RU2010120532A
Принадлежит:

... 1. Упаковка с защитным корпусом, содержащая устройство раздачи, причем защитный корпус содержит по меньшей мере один жесткий элемент. ! 2. Упаковка по п.1, в которой указанный жесткий элемент корпуса имеет углубление, выполненное с обеспечением размещения части устройства раздачи. ! 3. Упаковка по п.2, в которой форма углубления имеет сходство с формой устройства раздачи. ! 4. Упаковка по п.3, в которой углубление выполнено с обеспечением размещения в нем всего устройства раздачи, а защитный корпус дополнительно содержит по существу плоскую крышку, прикрепленную к указанному жесткому элементу корпуса. ! 5. Упаковка по п.4, в которой глубина углубления по существу равна наименьшему размеру устройства раздачи. ! 6. Упаковка по п.4, в которой глубина углубления по существу равна наибольшему размеру устройства раздачи. ! 7. Упаковка по п.1, в которой защитный корпус состоит из двух жестких элементов, которые прикреплены друг к другу и каждый из которых имеет углубление, выполненное с обеспечением ...

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10-07-2005 дата публикации

УПАКОВКА ДЛЯ АЭРОЗОЛЬНОЙ ТАРЫ И СПОСОБ ЕЕ ИЗГОТОВЛЕНИЯ

Номер: RU2005101759A
Принадлежит:

... 1. Способ поддержания замкнутого объема герметичной упаковки под давлением, приблизительно равным давлению окружающей среды, где данная упаковка включает аэрозольную тару с ингалятором с дозированной порцией (ИДП), содержащую лекарственный препарат и гидрофторалкановый пропеллент (ГФА), выбранный из группы, состоящей из ГФА 134а и ГФА р227 или их смеси, где способ включает следующие стадии: (i) помещение эффективного количества адсорбента ГФА и упомянутой аэрозольной тары внутрь герметизируемой упаковки; (ii) герметизация упаковки так, чтобы аэрозольная тара и адсорбент ГФА находились в замкнутом объеме внутри упаковки под давлением, приблизительно равным давлению окружающей среды; и (iii) адсорбирование любой утечки ГФА пропеллента адсорбентом ГФА для поддержания указанного замкнутого объема под давлением, приблизительно равным давлению окружающей среды. 2. Способ по п.1, отличающийся тем, что лекарственный препарат выбирают из группы, состоящей из бронхолитических, антигистаминных, противовирусных ...

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15-03-1966 дата публикации

Inhaling device of superoxygenated air.

Номер: OA0000000233A
Автор:
Принадлежит:

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31-10-2016 дата публикации

INHALER DEVICE

Номер: AP0201609515D0
Автор: PIETERS FRANK, RAO XERXES
Принадлежит:

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30-04-2010 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP0201005231D0
Принадлежит:

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20-04-2001 дата публикации

Metered dose inhaler for fluticasone propionate.

Номер: AP0000000960A
Принадлежит:

A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

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28-06-2001 дата публикации

Metered dose imhaler for salmeterol.

Номер: AP0000000979A
Принадлежит:

A metered dose Inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

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01-03-1994 дата публикации

Medicament dispensing device.

Номер: AP0000000320A
Принадлежит:

A meterd dose inhaler for use with a pressurised aerosol container which is preferably breath-actuated. A preload (80)is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force (130). The inhaler comprises a release device (110)which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve (135). A meterd dose of medicament is then released for inhalation by the patient.

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17-12-1999 дата публикации

Metered dose inhaler for albuterol.

Номер: AP0000000791A
Принадлежит:

A METERED DOSE INHALER HAVING PART OR ALL OF ITS INTERNAL SURFACES COATED WITH A POLYMER BLEND COMPRISING ONE OR MORE FLUOROCARBON POLYMERS, IN COMBINATION WITH ONE OR MORE NON-FLUOROCARBON POLYMERS, FOR DISPENSING AN INHALATION DRUG FORMULATION COMPRISING ALBUTEROL OR A PHYSIOLOGICALLY ACCEPTABLE SALT THEREOF, AND A FLUOROCARBON PROPELLANT, OPTIONALLY IN COMBINATION WITH ONE OR MORE OTHER PHARMACOLOGICALLY ACTIVE AGENTS AND ONE OR MORE EXCIPIENTS.

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12-05-2000 дата публикации

Metered dose inhaler for beclomethasone dipropionate.

Номер: AP0000000835A
Принадлежит:

A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fiuorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

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05-12-2002 дата публикации

Dispenser with doses counter.

Номер: AP0000001126A
Принадлежит:

There is provided a dispenser suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The dispenser comprises a housing (1) having a support (5); a container (2), locatable within said housing (1), having an outer member, wherein said container (2) is ovable relative to the housing (1) to en-able dispensing therefrom and said outlet member is connectable with said support (5) to prevent relative movement therebetween; and a dose indicator (13, 43), locatable within said housing (1). The container (2) and dose indicator (1 3, 43) are reversably removable from the housing (1) as a single unit.

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31-10-1997 дата публикации

Metered dose inhaler for albuterol

Номер: AP0009701114A0
Автор:
Принадлежит:

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13-01-2016 дата публикации

ANTI-MALARIAL PHARMACEUTICAL COMPOSITION

Номер: AP0000003542A
Принадлежит:

Подробнее
31-12-1999 дата публикации

Dispenser with doses counter

Номер: AP0009901705A0
Автор:
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for salmeterol

Номер: AP0009701113A0
Автор:
Принадлежит:

Подробнее
31-05-2014 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP0000002920A
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for fluticasone propionate

Номер: AP0009701111A0
Автор:
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for fluticasone propionate

Номер: AP0009701112A0
Автор:
Принадлежит:

Подробнее
31-12-2000 дата публикации

Valve for aerosol container.

Номер: AP2000001953A0
Принадлежит:

The invention provides a valve for an aerosol container suitable for use in dispensing a quantity of the contents thereof. The valve components comprise a fluorinated polymer and/or a fluorinated coating which have been found to reduce drug deposition in the valve.

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31-07-1992 дата публикации

MEDICAMENT DISPENSING DEVICE

Номер: AP0009200390A0
Автор:
Принадлежит:

Подробнее
30-09-2000 дата публикации

Improvements in drug delivery device

Номер: AP2000001920A0
Автор:
Принадлежит:

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30-04-2008 дата публикации

Orally absorbed pharmaceutical formulation and method of administration

Номер: AP2008004447A0
Принадлежит:

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30-06-2007 дата публикации

Method of delivery of therapeutic metal ions, alloys and salts

Номер: AP2007004039A0
Принадлежит:

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31-10-2016 дата публикации

INHALER DEVICE

Номер: AP2016009515A0
Автор: PIETERS FRANK, RAO XERXES
Принадлежит:

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30-11-2013 дата публикации

A dose counter

Номер: AP2013007275A0
Принадлежит:

Подробнее
31-07-2013 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP2013006997A0
Принадлежит:

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31-07-2013 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP0201306997A0
Принадлежит:

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25-03-2004 дата публикации

Improvement in drug delivery devices.

Номер: AP0000001264A
Принадлежит:

The invention relates to improvements in pressurised dispensing containers and particularly those for dispensing a metered dose of medicament. Pressurised dispensing container is provided for dispensing medicament wherein at least a portion of one or more of the internal surfaces of components of the pressurised dispensing container which come into contact with the medicament during storage or dispensing has a layer of one or more cold plasma preliminaried monomers bonded to at least a portion thereof.

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30-04-2010 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP2010005231A0
Принадлежит:

Подробнее
15-03-2001 дата публикации

Metered dose inhaler for fluticasone propionate

Номер: OA0000010624A
Принадлежит:

Подробнее
14-10-1996 дата публикации

Medicament dispensing device

Номер: OA0000010046A
Автор: DR BACON RAYMOND
Принадлежит:

Подробнее
24-04-2001 дата публикации

Metered dose inhaler for salmeterol

Номер: OA0000010626A
Принадлежит:

Подробнее
24-04-2001 дата публикации

Metered dose inhaler for beclomethasone dipropionate

Номер: OA0000010625A
Принадлежит:

Подробнее
24-04-2001 дата публикации

Metered dose inhaler for albuterol

Номер: OA0000010627A
Принадлежит:

Подробнее
30-09-2000 дата публикации

Improvements in drug delivery device

Номер: AP0200001920A0
Автор:
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for salmeterol

Номер: AP0009701113D0
Автор:
Принадлежит:

Подробнее
31-07-1992 дата публикации

MEDICAMENT DISPENSING DEVICE

Номер: AP0009200390D0
Автор:
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for fluticasone propionate

Номер: AP0009701112D0
Автор:
Принадлежит:

Подробнее
31-12-1999 дата публикации

Dispenser with doses counter

Номер: AP0009901705D0
Автор:
Принадлежит:

Подробнее
31-07-2013 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP0201306997D0
Принадлежит:

Подробнее
31-07-1993 дата публикации

DOSE INDICATING DEVICE

Номер: AP0009300531D0
Автор:
Принадлежит:

Подробнее
30-11-2013 дата публикации

A dose counter

Номер: AP0201307275D0
Принадлежит:

Подробнее
30-11-2013 дата публикации

A dose counter

Номер: AP0201307275A0
Принадлежит:

Подробнее
31-10-2016 дата публикации

INHALER DEVICE

Номер: AP0201609515A0
Автор: PIETERS FRANK, RAO XERXES
Принадлежит:

Подробнее
30-04-2008 дата публикации

Orally absorbed pharmaceutical formulation and method of administration

Номер: AP0200804447A0
Принадлежит:

Подробнее
30-04-2010 дата публикации

Anti-malarial pharmaceutical composition

Номер: AP0201005231A0
Принадлежит:

Подробнее
30-06-2007 дата публикации

Method of delivery of therapeutic metal ions, alloys and salts

Номер: AP0200704039A0
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for albuterol

Номер: AP0009701114D0
Автор:
Принадлежит:

Подробнее
31-10-1997 дата публикации

Metered dose inhaler for fluticasone propionate

Номер: AP0009701111D0
Автор:
Принадлежит:

Подробнее
31-07-1993 дата публикации

DOSE INDICATING DEVICE

Номер: AP0009300531A0
Автор:
Принадлежит:

Подробнее
31-12-2000 дата публикации

Valve for aerosol container

Номер: AP0200001953A0
Автор:
Принадлежит:

Подробнее
15-12-2008 дата публикации

MEDICINE DONOR

Номер: AT0000416806T
Принадлежит:

Подробнее
10-07-1981 дата публикации

DEVICE FOR DELIVERING EVEN DOSES OF A FINELY DISTRIBUTED ONE, IN A PROPELLANT SUSPENDED MEDICINE

Номер: AT0000363035B
Принадлежит:

Подробнее
15-02-2008 дата публикации

OPERATING NOZZLE OF A DOSING AERO BRINE

Номер: AT0000385203T
Автор: ZHAO JUNGUO, ZHAO, JUNGUO
Принадлежит:

Подробнее
26-02-1990 дата публикации

HERSTELLUNG VON AEROSOLZUSAMMENSETZUNGEN

Номер: AT0000389993B
Автор:
Принадлежит:

Подробнее
15-01-2008 дата публикации

DELIVERY DEVICE

Номер: AT0000382387T
Принадлежит:

Подробнее
15-09-2007 дата публикации

DOSE COUNTING DEVICES

Номер: AT0000370465T
Принадлежит:

Подробнее
15-10-2009 дата публикации

MEDICAL INHALATION APPARATUS

Номер: AT0000444091T
Принадлежит:

Подробнее
15-03-2011 дата публикации

FORMULATION OF AEROSOL COMPREHENSIVE LEVALBUTEROL LTARTRATSALZ

Номер: AT0000498604T
Принадлежит:

Подробнее
15-04-2010 дата публикации

DOSE COUNTER

Номер: AT0000464084T
Принадлежит:

Подробнее
09-02-2012 дата публикации

Nasal spray device

Номер: US20120031398A1
Принадлежит: Schering Corp

A delivery device ( 10 ) for the delivery of at least one dose of a composition into a nasal cavity, the device has a discharge member ( 12 ) formed for insertion into a nasal cavity, a discharge aperture ( 20 ) being formed therethrough and a body ( 14 ) containing a reservoir ( 24 ) of at least one dose, the body is elongated and generally extending along a longitudinal axis ( 16 ), wherein the discharge member ( 12 ) extends along a secondary axis ( 18 ), the secondary axis ( 18 ) intersecting with, and being disposed transversely to the longitudinal axis ( 16 ).

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23-02-2012 дата публикации

Aerosol medication inhalation system

Номер: US20120042874A1
Принадлежит: Pari Innovative Manufacturers Inc

An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

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05-04-2012 дата публикации

Visual indicator for an aerosol medication delivery apparatus and system

Номер: US20120080028A1
Принадлежит: TRUDELL MEDICAL INTERNATIONAL

A delivery system includes a holding chamber with first, second and third openings, and independently moveable first, second and third flow control members. A delivery system includes a holding chamber and a flow control member including a flap pivotable from an at rest position in a direction toward an outlet of a user interface and away from an output end of the holding chamber in response to a pressure being applied thereto.

Подробнее
12-04-2012 дата публикации

Nasal spray device

Номер: US20120085345A1

A nasal spray device for the delivery of a pharmaceutical formulation to the nasal cavity in metered doses. The device includes: a pressurised aerosol canister including a vial containing a pharmaceutical formulation including an active ingredient, a propellant and, optionally, a co-solvent, the aerosol canister further including a metering valve having a valve stem; and an actuator for the aerosol canister, the actuator including a stem block having a receptacle into which the valve stem of metering valve of the aerosol canister is received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump extending below the receptacle, the stem block further defining a discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the discharge orifice.

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19-04-2012 дата публикации

Method and tool for the cylindrical deformation of an al sleeve to the core dimension of the internal plastic closure, as preparation for a diffusion-proof press connection within the two components

Номер: US20120090153A1
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

In a method of producing a connection between the neck area of a light metal cartridge, particularly an aluminium cartridge, and a plastic container inserted therein, by a drawing process that forms a connection area and applies areas of the wall of the light metal cartridge against the plastic container using a rotating main body ( 15 ) of a drawing tool ( 2 ), said main body supporting at least one profiled drawing roller ( 3 ) which can rotate about a rotation axis ( 5 ) in order to delimit a tool working opening ( 1 ), wherein the drawing roller ( 3 ) lies against the outer surface of the light metal cartridge, the rotation axis ( 5 ) of the drawing roller ( 3 ) is arranged at a tool-internal end area of a lever ( 9 ) arranged transversely relative to the longitudinal axis ( 16 ) of the drawing tool ( 2 ), said lever being supported at its opposite tool-external end area on the drawing tool ( 2 ) so as to be pivotable about a pivot axis ( 11 ) in a force-controlled manner and so as to apply the drawing roller ( 3 ) against the outer surface of the light metal cartridge.

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17-05-2012 дата публикации

Artificial smoke cigarette

Номер: US20120118301A1
Автор: Akbar Montaser
Принадлежит: DOLSEY RICHARD DR

An artificial cigarette, inhaler or other nebulizer device may include a housing, an air passage into the housing, a fog generator chamber within the housing connected to the air passage, a liquid source connected to the fog generating chamber, and a fog generator within the fog generating chamber for receiving liquid from the liquid source and creating an aerosol. The fog generator may be an ultrasonic nebulizer and/or a pneumatic nebulizer.

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02-08-2012 дата публикации

Aerosol pirfenidone and pyridone analog compounds and uses thereof

Номер: US20120192861A1
Автор: Mark William Surber
Принадлежит: Genoa Pharmaceuticals Inc

Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.

Подробнее
23-08-2012 дата публикации

Inhaler for the administration of an anticholinergic

Номер: US20120211007A1
Автор: Bernd Zierenberg

An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 μm, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 μm to 500 μm, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 √{square root over (kPa)} min/L containing the inhalable powder.

Подробнее
20-09-2012 дата публикации

Dose counter

Номер: US20120234317A1
Автор: Adam J. Stuart
Принадлежит: Individual

Described are a dose counter ( 200 ) for use with an inhaler ( 5 ), and an actuator ( 20 ) for use with or as part of a dispenser. Further described is a dispenser containing a dose counter.

Подробнее
25-10-2012 дата публикации

Seal for a dispensing apparatus

Номер: US20120266871A1
Автор: Daljit S. Ohbi
Принадлежит: Consort Medical Ltd

The present invention relates to a seal for a valve for use in a pharmaceutical dispensing device, which seal is formed from an elastomeric composition comprising: (a) one or more elastomers; and (b) a cross-linking agent comprising an aliphatic dialkyl peroxide and/or an aliphatic perketal peroxide.

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01-11-2012 дата публикации

Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease

Номер: US20120277584A1
Принадлежит: Portaero Inc

A two-phase surgical procedure is disclosed for creating a pneumostoma to treat chronic obstructive pulmonary disease The first phase is a procedure to induce creation of a localized pleurodesis and is preferably performed as an outpatient procedure. The second phase is a procedure to introduce a surgical instrument into the lung via the pleurodesis to create the pneumostoma. An interval of about one of more days between the first and second phases allows the formation of a stable pleurodesis to prevent pneumothorax during the procedure.

Подробнее
27-12-2012 дата публикации

Apparatus and methods for microparticle dry coating of surfaces

Номер: US20120328768A1
Принадлежит: STC UNM

A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

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07-02-2013 дата публикации

Dose delivery device for inhalation

Номер: US20130032144A1
Принадлежит: Manta Devices LLC

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

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28-02-2013 дата публикации

Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof

Номер: US20130052260A1
Автор: Jeff Weers
Принадлежит: Insmed Inc

A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery device. A method for providing prophylaxis against a pulmonary infection in a patient and a method of reducing the loss of antiinfective encapsulated in a lipid-based composition upon nebulization comprising administering an aerosolized pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition is also disclosed.

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11-04-2013 дата публикации

METERED DOSE INHALER

Номер: US20130087142A1

The present invention relates to metered dose inhaler devices for the administration of medicament to patients for inhalation therapy. Particularly, it discloses a metered dose inhaler device for improving medicament compliance by patients. 1. An improved metered dose inhaler for delivery of medicament in the form of an aerosol comprising ,1. canister containing a medicament2. actuator means3. locking means that locks the actuator means and is unlocked upon shaking the device allowing the actuator means to deliver the medicament after it has been rendered homogeneous by shaking.2. An improved metered dose inhaler as claimed in wherein the locking means comprises a pendulum rod pivoted at the pivot point with the canister cap claim 1 , a striker which slides on the rod along its axis vertically claim 1 , spring and a slider.3. An improved metered dose inhaler as claimed in wherein the rod is in a shape such that it allows swaying of the rod with minimal friction at the pivot.4. An improved metered dose inhaler as claimed in wherein the striker freely slides on the pendulum rod along its axis vertically.5. An improved metered dose inhaler as claimed in wherein slider grips the rod such that an external force is required to move it along the pendulum rod axis.6. An improved metered dose inhaler as claimed in wherein the slider is at a distance away from the end of the pendulum rod such that one of its side edge is touching the profile spring preventing the swaying of the pendulum rod towards the spring. The present invention relates to metered dose inhaler devices for the administration of medicament to patients for inhalation therapy. Particularly, it discloses a metered dose inhaler device for improving medicament compliance by patients.Inhalation has long been known as a method of administering medicines for distribution and absorption into the airways, lungs, and nasal passages. Inhalation devices are the predominant medicament delivery system for treating ...

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25-04-2013 дата публикации

Nasal Delivery Devices

Номер: US20130098362A1
Принадлежит: OPTINOSE AS

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container. 1a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet;a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber;a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; anda moisture-reducing element for reducing condensation at or downstream of the container chamber.. A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: This application is a continuation of U.S. patent application Ser. No. 11/663,099, filed Aug. 22, 2007, which is a National Phase Application of International Application No. PCT/GB2005/003549, filed on Sep. 15, 2005, which claims the benefit ...

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02-05-2013 дата публикации

Dry Powder Drug Delivery System and Methods

Номер: US20130104887A1
Принадлежит: MANNKIND CORPORATION

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity. 1. A dry powder inhaler comprising:a) a mouthpiece;b) a container housing; andc) at least one rigid air conduit;wherein the dry powder inhaler is configured to emit greater than about 75% of a dry powder from a container oriented in the container housing as powder particles in a single inhalation, and the powder particles emitted have a volumetric median geometric diameter of less than about 5 microns when the single inhalation through the mouthpiece generates a peak inspiratory pressure of about 2 kPa within two seconds.2. The dry powder inhaler of having a resistance value to airflow ranging from about 0.065 (√kPa)/liter per minute to about 0.200 (√kPa)/liter per minute.3. The dry powder inhaler of claim 1 , wherein the dry powder is a formulation for pulmonary delivery and comprises an amount from about 1 mg to about 30 mg of the dry powder.4. The dry powder inhaler of claim 1 , wherein the dry powder comprises a diketopiperazine or a pharmaceutically acceptable salt thereof.5. The dry powder inhaler of claim 4 , wherein the diketopiperazine is of the formula 2 claim 4 ,5-diketo-3 claim 4 ,6-bis(N—X-4-aminobutyl)piperazine claim 4 , wherein X is selected from the group consisting of fumaryl claim 4 , succinyl claim 4 , maleyl claim 4 , and glutaryl.6. The method of claim 5 , wherein the diketopiperazine is (bis-3 claim 5 ,6-(N-fumaryl-4-aminobutyl)-2 claim 5 ,5-diketo-diketopiperazine.7. The dry powder inhaler of claim 1 , wherein the dry powder comprises a drug ...

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09-05-2013 дата публикации

PROCESS FOR PROVIDING A FILLED CANISTER FOR AN INHALER

Номер: US20130112194A1
Принадлежит:

A process for filling a canister for an inhaler is provided. The canister may be filled with components of a medicament. The canister may be suitable for use in a pressurised metered dose inhaler, such as a breath-actuate inhaler. The process may include sealing the canister with air at ambient conditions. A filling device may dispense a pressurised liquid or gas into the sealed, air-filled canister through a metering valve. The pressurised liquid or gas may comprise at least a propellant. While pressure-filled canisters were previously purged with propellant immediately before sealing to remove the air, the present process may exclude the purging step. 1. A process for providing a filled canister for an inhaler , the process comprising the steps of:providing a canister, the canister comprising an enclosure suitable for containing a medicament and having an opening for receiving the medicament, and the canister being substantially filled with air at ambient conditions;sealing the opening of the air-filled canister by securing thereto at least one of a metering valve and a sealing mechanism;providing the sealed, air-filled canister to a filling device; anddispensing from the filling device a pressurised liquid or gas into the sealed, air-filled canister through at least one of the metering valve and a sealing mechanism, the pressurised liquid and/or gas comprising at least a propellant,wherein:the sealed canister is substantially devoid of propellant prior to the step of dispensing the pressurised liquid or gas; andthe sealed canister is substantially filled with at least a first proportion of propellant and a second proportion of air after the step of dispensing the pressurised liquid or gas.2. The process for providing a filled canister as claimed in claim 1 , further comprising the steps of:providing the air-filled canister to a medicament dispenser, prior to the step of sealing the opening of the air-filled canister; anddispensing from the medicament dispenser a ...

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23-05-2013 дата публикации

Delivery Devices

Номер: US20130125889A1
Принадлежит: OPTINOSE AS

A breath-actuated delivery device includes a mouthpiece through which a subject in use exhales, an air channel which is in fluid communication with the mouthpiece, and a flexible diaphragm which is disposed in the air channel. The diaphragm provides for at least a restricted air flow through the air channel until a predeterminable actuation pressure is developed in the mouthpiece, and, on generation of the predeterminable actuation pressure in the mouthpiece, provides for an air flow through the air channel. 1. A breath-actuated delivery device , comprising:a mouthpiece through which a subject in use exhales;an air channel which is in fluid communication with the mouthpiece; anda flexible diaphragm which is disposed in the air channel, the diaphragm providing for at least a restricted air flow through the air channel until a predeterminable actuation pressure is developed in the mouthpiece, and, on generation of the predeterminable actuation pressure in the mouthpiece, providing for an air flow through the air channel.2. The delivery device of claim 1 , wherein the diaphragm at least substantially closes the air channel until the predeterminable actuation pressure is developed in the mouthpiece.3. The delivery device of claim 2 , wherein the diaphragm closes the air channel until the predeterminable actuation pressure is developed in the mouthpiece.4. The delivery device of claim 1 , further comprising a rupturing element for rupturing the diaphragm on generation of the predeterminable actuation pressure in the mouthpiece.5. The delivery device of claim 1 , wherein the diaphragm is a resilient element.6. The delivery device of claim 1 , wherein the delivery device is a nasal delivery device claim 1 , and further comprising a nosepiece for fitting to a nostril of the subject and through which substance is delivered to the nasal airway of the subject.7. The delivery device of claim 6 , wherein the nosepiece is in fluid communication with the air channel claim 6 , and ...

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30-05-2013 дата публикации

Inhalation Device

Номер: US20130133643A1
Принадлежит: AstraZeneca AB

An actuator for an inhaler for delivering medicament by inhalation, comprising: a main body comprising a tubular member for receiving a canister containing medicament and having a valve stem extending therefrom; and an outlet assembly, as a part formed separately of the main body, comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister into the mouthpiece; wherein the main body is provided with an outlet opening for receiving the outlet assembly in a position wherein the mouthpiece extends outside the outlet opening and the nozzle block is inserted through the outlet opening and arranged in position for receiving the valve stem of the canister. There is also disclosed an inhaler comprising the above-described actuator and a canister containing medicament, a main body and an outlet assembly. 153-. (canceled)54. An actuator for an inhaler for delivering medicament by inhalation , comprising:a main body configured to receive a canister with a valve stem extending therefrom, wherein the main body includes an end portion formed as a foot that allows the actuator to stand unsupported with the main body extending generally vertically from the foot; andan outlet assembly formed separate from the main body, wherein the outlet assembly has a mouthpiece with a nozzle block for receiving the valve stem of the canister.55. The actuator of claim 54 , wherein the nozzle block is supported by the end surface.56. The actuator of claim 54 , wherein the foot includes a recess configured to receive a digit of a user.57. The actuator of claim 56 , wherein the recess is concave.58. The actuator of claim 54 , wherein a bottom-most surface of the foot is substantially flat.59. The actuator of claim 54 , wherein the nozzle block has a longitudinal axis that is generally parallel to a longitudinal axis of the main body.60. The actuator of claim 54 , wherein the foot ...

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06-06-2013 дата публикации

VAPORIZER WITH COMBINED AIR AND RADIATION HEATING

Номер: US20130139813A1
Автор: Storz Markus
Принадлежит: Stobi GmbH & Co. KG

A hot air extraction vaporizer that is provided with a heat exchanger, a filling chamber for accommodating a substance generating an aerosol when subjected to heat, and a vaporizer outlet for inhaling the aerosol/air mixture. The heat exchanger is in a thermally conductive connection with the filling chamber that when heated up subjects the substance to radiant heat. The heat exchanger is provided with at least one airflow channel generating a hot airflow. The filling chamber comprises at least one of airflow passages and a mesh allowing the hot airflow to pass through the filling chamber and the substance provided therein. 1. A hot air extraction vaporizer , comprising:a heat exchanger;a filling chamber for accommodating a substance generating an aerosol when subjected to heat; anda vaporizer outlet for inhaling the aerosol/air mixture; whereinthe heat exchanger is in an thermally conductive connection with the filling chamber that when heated up subjects the substance to radiant heat;the heat exchanger comprises at least one airflow channel generating a hot airflow; andthe filling chamber comprises at least one of airflow passages and a mesh allowing the hot airflow to pass through the filling chamber and the substance provided therein.2. The hot air extraction vaporizer according to claim 1 , wherein the filling chamber further comprises an inner chamber housing that is integrally formed with the heat exchanger.3. The hot air extraction vaporizer according to claim 1 , wherein the filling chamber further comprises an inner chamber housing and the filling chamber and with it the inner chamber housing are removable from the heat exchanger and the inner chamber housing is connected in an attached position to the heat exchanger in a heat conductive fashion.4. The hot air extraction vaporizer according to claim 3 , wherein the inner chamber housing of the filling chamber abuts in its attached position with its front face against the heat exchanger.5. The hot air ...

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06-06-2013 дата публикации

HUMIDIFIED PARTICLES COMPRISING A THERAPEUTICALLY ACTIVE SUBSTANCE

Номер: US20130142782A1
Принадлежит: TAKEDA GMBH

The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods. 1. Particles , comprising at least one therapeutically active substance and being obtainable by the following steps:a. providing essentially dry inhalable particles comprising the at least one therapeutically active substance,b. suspending the particles of step (a) in a carrier gas to obtain a first aerosol,c. adding water vapor to the first aerosol to obtain a second aerosol having a higher water content than the first aerosol, andd. adjusting the temperature and/or the pressure of the second aerosol as to exceed the second aerosol's dew point and to cause condensation of water on the particles.3. Particles according to claim 2 , wherein the source of water vapor in step (i) is a semi-permeable barrier claim 2 , and the adding water vapor to the first aerosol is accomplished by flowing the first aerosol through the humidification chamber of a humidifier claim 2 , the humidifier being characterized by said semi-permeable barrier which separates the first aerosol in the humidification chamber from water at a temperature of 37-100° C. in a second chamber claim 2 , and which semi-permeable barrier allows the passage of water vapor and optionally the passage of heat claim 2 , but blocks the passage of liquid water claim 2 , from the second chamber to the humidification chamber.4. Particles according to claim 1 , wherein in step (d) the second aerosol's dew point is exceeded by lowering the second aerosol's temperature from a first temperature to a second temperature.5. Particles according to claim 4 , wherein the second aerosol's first temperature is between 20° C. and 100° C.6. Particles according to ...

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06-06-2013 дата публикации

Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain

Номер: US20130142868A1
Принадлежит: UNIVERSITY OF WASHINGTON

Methods of delivering a pharmaceutical compounds directly to the olfactory epithelium of a mammal by providing a pharmaceutical aerosol suspension comprising an aerosol and the pharmaceutical compound; aerosolizing the suspension to generate a stream of droplets, the stream having a rotational component, and, delivering the droplets directly to the olfactory epithelium, wherein at least 15% of the droplets are delivered directly to the olfactory deposition. The pharmaceutical compound may be encapsulated within a liposome nanoparticle.

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13-06-2013 дата публикации

Respirably dry powder comprising calcium lactate, sodium chloride and leucine

Номер: US20130149345A1
Принадлежит: Pulmatrix Inc

The present invention relates to respirable dry powders that contain respirable dry particles that comprise about 20% (w/w) leucine, about 75% (w/w) calcium lactate, and about 5% (w/w) sodium chloride, or about 37.5% (w/w) leucine, about 58.6% (w/w) calcium lactate, and about 3.9% (w/w) sodium chloride, and methods for treating a subject using the respirable dry powders.

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20-06-2013 дата публикации

DRY POWDER INHALERS THAT INHIBIT AGGLOMERATION, RELATED DEVICES AND METHODS

Номер: US20130152926A1
Принадлежит: Oriel Therapeutics, Inc.

Inhalers with fins that deagglomerate dry powder using inspiratory effort of a user of an inhaler. The inhaler fins, at least in steady state conditions, are configured to generate dry powder and airflow patterns having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation. 1. A method of deagglomerating dry powder in a dry powder inhaler , comprising:generating a dry powder and air flow pattern having flow vortices using at least one fin that extends across at least a portion of an inspiratory flow path, wherein the at least one fin generates a plurality of point induced flow vortices at a common axial location so that some of the vortices have an opposite rotation relative to others about a respective axis of rotation that extends axially in the inspiratory flow direction of dry powder and air flow to thereby facilitate deagglomeration of the dry powder without trapping undue amounts of the dry powder in the inhaler.2. A method according to claim 1 , wherein the generating step employs a plurality of spaced apart statically configured fins that reside in the inspiratory airflow path claim 1 , each having at least one point and least two edge portions that meet to define the at least one point claim 1 , the fins creating point and edge induced flow vortices in the dry powder and air airflow pattern claim 1 , wherein the point induced flow vortices have a corresponding respective axis of rotation that extends in the inspiratory flow direction claim 1 , wherein the edge induced flow vortices are shedding vortices that have a corresponding respective axis of rotation that is substantially ...

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04-07-2013 дата публикации

Apparatus, system and method for detection and delivery of a medicinal dose

Номер: US20130172690A1
Принадлежит: Proteus Digital Health Inc

An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.

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18-07-2013 дата публикации

Nasal delivary device

Номер: US20130180524A1
Принадлежит: SIPNOSE Ltd

It is one object of the present invention to provide an air-intake actuated device adapted for delivering a substance to a nasal cavity of a subject, comprising: a. a container for containing said substance; b. a nosepiece extending from said device for placement in proximity to a nose of said subject. c. a valve mechanically connectable to said container, characterized by an ACTIVE CONFIGURATION and an INACTIVE CONFIGURATION; and, d. a trigger mechanism adapted to reconfigure said valve from said ACTIVE CONFIGURATION to said INACTIVE CONFIGURATION, and vice versa; wherein said trigger mechanism is activated by means of said subject intaking air through said mouthpiece; further wherein said trigger mechanism is adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION for a predetermined period of time in response to said subject intake of air.

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01-08-2013 дата публикации

Nebulizer that is activated by negative inspiratory pressure

Номер: US20130192594A1
Принадлежит: Pneumoflex Systems LLC

A nebulizer includes an air channel section and medication reservoir. An air line extends through the air channel section. A venturi nozzle is at its end and configured to form a low pressure mixing chamber. A vent is formed in the body and communicates with the air channel section and medication reservoir to vent the air channel section and medication reservoir to outside ambient air. A primary suction line extends from the medication reservoir to the low pressure mixing chamber through which medication is drawn upward and mixed with air passing through the venturi nozzle and nebulized for discharge. The vent is configured to vent the air channel section and medication reservoir to atmospheric pressure such that at standard temperature and pressure (STP), a differential pressure results between the venturi nozzle and medication reservoir such that no medication is drawn upward through the primary suction line.

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08-08-2013 дата публикации

INHALER CAP STRAP

Номер: US20130199525A1
Автор: BUNCE Martin
Принадлежит: AstraZeneca AB

An inhaler for dispensing doses of medicament from a container under user activation said inhaling which comprises a body which includes a mouthpiece through which the medicament is dispensed and a cap which can be place in a position to substantially occlude the mouthpiece. The cap is attached to said body by a strap which pivots from said body, said cap being arranged to slide on the strap such that the cap must translate away from the mouthpiece prior to the pivoting of the strap. 18-. (canceled)9. An inhaler comprising:a body including a mouthpiece; anda cap coupled to the body by a strap, wherein the cap is configured to translate towards and away from the mouthpiece, and wherein the cap includes an opening for receiving the strap as the cap translates towards the mouthpiece.10. The inhaler of claim 9 , wherein the caps is configured to slide along the strap.11. The inhaler of claim 9 , wherein the cap is configured to occlude the mouthpiece.12. The inhaler of claim 9 , wherein the strap is configured to pivot relative to the body.13. The inhaler of claim 12 , wherein the strap is configured to pivot away from the body after the cap translates away from the mouthpiece.14. The inhaler of claim 9 , wherein the cap includes a lug configured to couple the cap to the strap.15. An inhaler comprising:a body including a mouthpiece; anda cap coupled to the body by a strap, wherein the cap is configured to translate towards and away from the mouthpiece by sliding along the strap, and wherein the strap is formed of a non-elastic material.16. The inhaler of claim 15 , wherein the strap is formed of a rigid material.17. The inhaler of claim 15 , wherein the strap includes a channel claim 15 , and the cap includes a lug claim 15 , and wherein the lug is configured to slide along the channel.18. The inhaler of claim 17 , wherein the channel includes a first stop and a second stop claim 17 , and wherein the lug is configured to slide along the channel between the first stop ...

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08-08-2013 дата публикации

DRY POWDER INHALER AND SYSTEM FOR DRUG DELIVERY

Номер: US20130199527A1
Принадлежит: MANNKIND CORPORATION

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable. 1. A dry powder medicament cartridge for an inhaler , comprising:an enclosure configured to hold a medicament;at least one inlet port to allow flow into the enclosure, and at least one dispensing port to allow flow out of the enclosure;wherein the at least one inlet port is configured to direct at least a portion of the flow entering the at least one inlet port at the at least one dispensing port within the enclosure in response to a pressure differential.2. The cartridge of claim 1 , wherein the medicament comprises an active ingredient.3. The cartridge of claim 2 , wherein the active ingredient is a hormone claim 2 , an anticoagulant claim 2 , an immunomodulating agent claim 2 , a vaccine claim 2 , a cytotoxic agent claim 2 , an antibiotic claim 2 , a vasoactive agent claim 2 , a neuroactive agent claim 2 , an anaesthetic claim 2 , sedative claim 2 , a steroid claim 2 , a decongestant claim 2 , an antiviral claim 2 , an antisense claim 2 , an antigen claim 2 , or an antibody.4. The cartridge of claim 2 , wherein the active ingredient is insulin claim 2 , heparin claim 2 , calcitonin claim 2 , felbamate claim 2 , sumatriptan claim 2 , ...

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08-08-2013 дата публикации

Medicant Delivery System

Номер: US20130199528A1
Принадлежит: CHONG CORPORATION

An improved medicant delivery system is disclosed wherein the carrier for the medicant is a fluid that can be atomized or vaporized by exposure to heat. The system provides for repeatable dose of medicant, can be stored in any orientation, and/or has an ability to maximize energy efficiency. 1. A control system for a hand-held vapor delivery device , comprising: a circuit configured to provide a precise amount of power from a power source to heat a heating element to a minimum required temperature to completely vaporize a predetermined volume of a liquid , and control a precise duration of time to supply the precise amount of power to completely vaporize the predetermined volume of liquid at the required temperature.2. The control system of claim 1 , wherein the circuit comprises a one-shot circuit.3. The hand-held vaporizing device of claim 1 , wherein the circuit further comprises a processor programmed to monitor a resistance of the heating element and adjust the amount of power to a level sufficient to heat the heating element to the required temperature.4. The control system of claim 1 , wherein the circuit comprises a DC/DC boost converter and a supercapacitor operatively connected to the power source to adjust the amount of power to the level sufficient to heat the heating element to the required temperature.5. The hand-held vaporizing device of claim 1 , wherein the circuit is configured to actuate the power source a predetermined number of times.6. A hand-held medicant delivery device claim 1 , comprising:a. a housing having a first end and a second end;b. a mouthpiece attached to the first end;c. a fluid delivery system;d. a vaporization system, comprising a heating element in between the mouthpiece and the fluid reservoir; ande. a power control system, comprising a circuit configured to provide a precise amount of power from a power source to heat the heating element to a required temperature to completely vaporize the precise volume of the liquid, and ...

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08-08-2013 дата публикации

System to diagnose the function of intrinsic sphincters

Номер: US20130204313A1
Принадлежит: Pneumoflex Systems LLC

A system treats at least one of the urethral and anal sphincters. A muscle contraction device is located on at least one of the urethral and anal sphincters. A controller is connected to the muscle contraction device and operative to transmit control signals to the muscle contraction device located on at least one of the urethral and anal sphincters to contract the muscle during an inspiratory phase of respiration.

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22-08-2013 дата публикации

METHOD AND DEVICE FOR CLAMPING A BLISTER WITHIN A DRY POWDER INHALER

Номер: US20130213392A1
Автор: Mosier Kent D.
Принадлежит: MICRODOSE THERAPEUTX, INC.

The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein individual blister packs are positioned within the housing to be simultaneously engaged with the flow channel and the vibration element. The flow channel includes a blister pack clamping surface that engages the blister pack near the top of the crown and allows the blister three rotational degrees of freedom. The advantages of this arrangement include improved consistency and higher airspeed of the synthetic jet, as well as other advantages. 1. A medication inhaler , comprisinga housing for accommodating a blister containing a medication;a vibrating element within the housing; anda chamber defining a flow channel communicating with the blister, wherein the blister is clamped in position adjacent the vibrating element by the chamber.2. The inhaler of claim 1 , wherein the blister comprises a first face and a second face claim 1 , the second face being positioned in contact with the vibrating element.3. The inhaler of claim 1 , wherein the blister comprises a first face and a second face claim 1 , the first face having a crown claim 1 , the first face being engaged at least in part with the chamber.4. The inhaler of claim 3 , wherein the chamber further comprises a blister pack clamping surface claim 3 , allowing three rotational degrees of freedom between the chamber and blister pack.5. The inhaler of claim 3 , wherein the chamber further comprises a blister pack clamping surface that surrounds claim 3 , at least in part claim 3 , the crown of the blister pack.6. The inhaler of claim 5 , wherein the blister pack clamping surface engages the first face of the blister pack that is closer to the top of the crown than to the base of the crown.7. The inhaler of claim 1 , wherein the vibrating element is a piezoelectric transducer.8. The inhaler of claim 1 , wherein the medication comprises a dry powder.9. The inhaler of claim 1 , wherein ...

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22-08-2013 дата публикации

MEDICINAL INHALATION DEVICES AND COMPONENTS THEREOF

Номер: US20130213395A1
Принадлежит: 3M INNOVATIVE PROPERTIES COMPANY

A medicinal inhalation device having a non-metal coating applied by plasma deposition under ion bombardment conditions. 1. A method of making a medicinal inhalation device comprising:a) forming a non-metal coating on at least a portion of a surface of the device, said coating having at least one functional group;b) applying to at least a portion of a surface of the non-metal coating a composition comprising an at least partially fluorinated compound comprising at least one functional group; andc) allowing at least one functional group of the at least partially fluorinated compound to react with at least one functional group of the non-metal coating to form a covalent bond; andwherein the at least partially fluorinated compound comprising at least one functional group is a polyfluoropolyether silane, in particular a multifunctional polyfluoropolyether silane, and more particularly a difunctional polyfluoropolyether silane; and {'br': None, 'sub': f', '2', '3-x', 'x', 'y', 'z, 'sup': '1a', 'R[Q-[C(R)—Si(Y)(R)]]\u2003\u2003Ia'}, 'wherein the polyfluoropolyether silane is of Formula Ia [{'sub': 'f', 'Ris a monovalent or multivalent polyfluoropolyether segment;'}, 'Q is an organic divalent or trivalent linking group;', {'sub': '1-4', 'each R is independently hydrogen or a Calkyl group;'}, 'each Y is independently a hydrolysable group;', {'sup': '1a', 'sub': '1-8', 'Ris a Calkyl or phenyl group;'}, 'x is 0 or 1 or 2;', 'y is 1 or 2; and', 'z is 1, 2, 3, or 4., 'wherein2. A method according to claim 1 , wherein the polyfluoropolyether segment claim 1 , R claim 1 , comprises perfluorinated repeating units selected from the group consisting of —(CFO)— claim 1 , —(CF(Z)O)— claim 1 , —(CF(Z)CFO)— claim 1 , —(CFCF(Z)O)— claim 1 , —(CFCF(Z)O)— claim 1 , and combinations thereof; wherein n is an integer from 1 to 6 and Z is a perfluoroalkyl group claim 1 , an oxygen-containing perfluoroalkyl group claim 1 , a perfluoroalkoxy group claim 1 , or an oxygen-substituted ...

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29-08-2013 дата публикации

Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof

Номер: US20130224259A1
Принадлежит: Leland Stanford Junior University

The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.

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19-09-2013 дата публикации

ACTUATOR DEVICES FOR INHALERS

Номер: US20130239957A1
Автор: Pinfold Andrew
Принадлежит: RELEVO LIMITED

An actuator for attachment to an inhaler of the type including a pressurized canister of medicine, the actuator comprising a sensor for detecting the presence of a patient to whom medicine is to be delivered from the pressurized canister; and the actuator comprising an electrically driven mechanical linear motion to trigger a lever which is moveable between an at rest position and an in use position in which the lever exerts a force on the canister so as to operate the inhaler and thereby release medicine from the pressurized canister to provide ease of use of the inhaler for patients with reduced or limited dexterity and grip/co-ordination. The actuator device can provide data logging using non-volatile internal memory; the data being capable of being downloaded via physical interface or Bluetooth. 1. An actuator device for engagement with an inhaler of the type including a pressurized canister of medicine , the actuator comprising detecting means for detecting the presence of a patient to whom medicine is to be delivered from the pressurized canister; and the actuator comprising a mechanical linear motion to operate a lever which is moveable between an “at rest” position and an “in use” position in which , in use , the lever exerts a force on the canister so as to operate the inhaler and release medicine from the pressurized canister.2. The actuator device of wherein the means for detecting the presence of a patient comprises a sensor.3. The actuator device of wherein the sensor is a lip triggered sensor which is triggered when the sensor detects the presence of a person's lips in contact with a mouth piece of the inhaler; optionally wherein the lip triggered sensor is provided on the actuator device which is in the form of a housing which claim 2 , in use claim 2 , connects onto the mouth piece of the inhaler.4. The actuator device of wherein the sensor comprises a breath activated sensor.5. The actuator device of having a clip-in connection for engaging the ...

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26-09-2013 дата публикации

SELF-SENSING RESPIRATORY TREATMENT DEVICE

Номер: US20130247902A1
Принадлежит: Henkel AG & Co. KGaa

A respiratory treatment device comprising a self-sensing respiratory treatment device comprising: power supply means; a liquid dispensing element comprising an actuator and a dispensing aperture; electronic control means operable to control said actuator; liquid supply means; valving means; wherein said actuator is operable to execute in itself at least a dispensing function and a detecting function, the detecting function detecting at least characteristics external to the self-sensing respiratory treatment device and causing said actuator to generate a command signal, and wherein said electronic control means is operable to control said valving means and said actuator based on the reception of said command signal, wherein said actuator is a piezoelectric actuator, and the respiratory treatment device further comprising: a mouthpiece, and a fluidic interface, wherein said electronic control means and said piezoelectric actuator being arranged to detect a breathing pattern of a user through said mouthpiece. 1. Respiratory treatment device comprising: power supply means,', 'a liquid dispensing element comprising an actuator and a dispensing aperture through which liquid is to be dispensed by activation of the actuator,', 'electronic control means operable to control said actuator,', 'liquid supply means for connecting with a liquid reservoir to supply liquid from said reservoir to said liquid dispensing element,', 'valving means for allowing or blocking liquid to flow from said reservoir through said liquid supply means to said liquid dispensing element,', 'wherein said actuator is operable to execute in itself at least a dispensing function and a detecting function, the detecting function detecting at least characteristics external to the self-sensing respiratory treatment device and causing said actuator to generate a command signal, and', 'wherein said electronic control means is operable to control said valving means and said actuator based on the reception of ...

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26-09-2013 дата публикации

NEBULIZER APPARATUS AND METHOD

Номер: US20130247903A1
Принадлежит:

A nebulizer for efficiently and reliably delivering aerosolized fluid to an inhaling patient is disclosed. The nebulizer includes a fluid channel air inlet and fluid channel air inlet valve responsive to either a manual force external of the nebulizer, or a patient's breathing, to begin the nebulization process. Also provided is a method of providing nebulization including the steps of moving a fluid channel air inlet valve against a fluid channel air inlet so that a negative pressure may build up over the fluid in the fluid channel to draw fluid from the fluid reservoir and begin nebulization during inhalation. 135.-. (canceled)36. A nebulizer for generating an aerosol , the nebulizer comprising:a housing having an air inlet and a chamber for holding the aerosol;an air outlet communicating with the chamber for permitting the aerosol to be withdrawn from the chamber;a pressurized gas inlet located in the chamber;a diverter surface positioned in the chamber in a fixed position relative to the pressurized gas inlet, the diverter surface defining a fluid orifice positioned at a non-parallel angle to the fluid orifice, wherein the diverter surface is positioned to divert gas issuing from the pressurized gas inlet over the fluid orifice defined by diverter surface;a fluid channel in communication with the fluid orifice;a fluid channel air inlet in communication with the fluid channel; anda fluid channel air inlet valve movably positioned adjacent the fluid channel air inlet, wherein the fluid channel air inlet valve is moveable in response to a patient's breathing between a nebulizing position, where the fluid channel air inlet valve seals against the fluid channel air inlet to permit a negative pressure to draw a fluid through the fluid channel, and a non-nebulizing position, wherein the fluid channel air inlet valve is configured to permit air to enter the fluid channel air inlet so as to prevent formation of a negative pressure sufficient to draw the fluid through the ...

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10-10-2013 дата публикации

NASAL DELIVARY DEVICE

Номер: US20130263849A1
Принадлежит:

It is one object of the present invention to provide an air-intake actuated device adapted for delivering a substance to a nasal cavity of a subject, comprising: 2. The drinking-actuated device according to claim 1 , wherein said trigger mechanism is adapted to reconfigure said valve from said ACTIVE CONFIGURATION to said INACTIVE CONFIGURATION when said pressure gradient is absent.3. The drinking-actuated device according to claim 1 , wherein said trigger mechanism comprises a controlling member adapted to move reciprocally in responsive to said pressure gradient; said controlling member is characterized by having at least two configurations: (i) an CLOSED CONFIGURATION in which said fluid is not provided to said subject via said tubule and said valve is in said INACTIVE CONFIGURATION; and claim 1 , (ii) an OPENED CONFIGURATION in which said subject drinks said fluid through said tubule and said valve is in said ACTIVE CONFIGURATION; further wherein in said CLOSED CONFIGURATION claim 1 , said controlling member is adapted to block the passage of said fluid from said fluid reservoir to said mouthpiece.4. The drinking-actuated device according to claim 3 , wherein said trigger mechanism further comprises flexible membrane claim 3 , said flexible membrane is adapted to reconfigure its shape in response to said pressure gradient caused by said suction applied by said subject to said tubule claim 3 , such that said controlling member is reconfigured from said CLOSED CONFIGURATION to said OPENED CONFIGRATION claim 3 , and vise versa.5. The drinking-actuated device according to claim 4 , wherein at least one of the following is being held true (a) said controlling member is characterized by at least three portions: a first end positioned at least partially within said tubule; a middle portion mechanically connected with said membrane; and claim 4 , a second end in communication with said valve; (b) said controlling member comprises a first aperture fluidly communicating ...

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17-10-2013 дата публикации

INHALER

Номер: US20130269685A1
Принадлежит:

An inhaler is proposed having an insertable container and a monitoring device for counting uses of the inhaler. The monitoring device is arranged in a detachable housing part or fitted onto a mouthpiece of the inhaler. A supply air current is detected by means of a pressure sensor. A position sensor may further be provided. 112. Inhaler () for a fluid (){'b': 3', '2, 'having an insertable container () containing the fluid () and'}{'b': 24', '1, 'having a monitoring device () for detecting use of the inhaler (),'}characterised in that{'b': 24', '29', '1', '24', '1', '1, 'the monitoring device () has a pressure sensor () for measuring the air pressure in the inhaler () or the monitoring device () for detecting inhalation and/or a position sensor for detecting a position, orientation and/or acceleration of the inhaler () to determine a path of movement of the inhaler ().'}212944131. Inhaler () according to claim 1 , characterised in that the pressure sensor () is arranged outside a supply air pathway () and/or mouthpiece () of the inhaler ().3129181131. Inhaler () according to claim 1 , characterised in that the pressure sensor () is arranged in an actuating or housing part () of the inhaler () which is fluidically connected to a mouthpiece () of the inhaler ().4124291. Inhaler () according to claim 1 , characterised in that the monitoring device () or the pressure sensor () is designed to measure or detect reduced pressure in the inhaler () during inhalation.5124. Inhaler () according to claim 1 , characterised in that the monitoring device () is designed to detect a pressure pattern beginning before a nebulisation and/or inhalation.613031. Inhaler () according to claim 1 , characterised in that the position sensor is an acceleration sensor () or a GPS sensor ().71. Inhaler () according to claim 1 ,{'b': 3', '2, 'having an insertable container () holding the fluid () and'}{'b': 24', '1, 'having a monitoring device () for detecting use of the inhaler (),'}characterised ...

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31-10-2013 дата публикации

Method for diagnosing the function of intrinsic sphincters

Номер: US20130289363A1
Принадлежит: Pneumoflex Systems LLC

A method for treating at least one of the urethral and anal sphincters in a patient includes inducing an involuntary reflex cough event within the patient to determine whether a dysfunction exists in at least one of the urethral and anal sphincters. If a dysfunction is determined to exist, then contracting a muscle located at one of at least the urethral and anal sphincters during an inspiratory phase of respiration.

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07-11-2013 дата публикации

Spacer and components therefor

Номер: US20130291862A1
Автор: Allan Eagle
Принадлежит: Medical Developments International Ltd

A spacer comprising a polycarbonate chamber and a flow valve located within the chamber. The chamber comprises: a first reservoir and a second reservoir; an inlet for admission of aerosolized medication into the first reservoir; an outlet for withdrawal of medication from the second reservoir; and a vent for expulsion of air from the second reservoir. The flow valve is adapted to: allow forward-flow of medication from the first reservoir to the second reservoir during user inspiration; substantially limit inflow of air through the vent into the second reservoir during user inspiration, substantially limit backflow of air or medication from the second reservoir to the first reservoir during user expiration; and allow expulsion of air from the second reservoir through the vent during user expiration.

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07-11-2013 дата публикации

Directional flow sensor inhaler

Номер: US20130291864A1
Принадлежит: MicroDose Therapeutx Inc

An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator.

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07-11-2013 дата публикации

DRY POWDER INHALER AND SYSTEM FOR DRUG DELIVERY

Номер: US20130291866A1
Принадлежит:

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

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07-11-2013 дата публикации

DRY POWDER DRUG DELIVERY SYSTEM

Номер: US20130291867A1
Принадлежит:

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation. 1. An inhalation system , comprising:a dry powder inhaler comprising a mouthpiece and a container, wherein the container includes a dry powder formulation comprising diketopiperazine particles; a first flow path wherein 20% to 70% of total airflow through the inhaler enters and exits the container; and a second flow path wherein 30-80% of total airflow through the inhaler by-passes the container;{'sub': '0-∞', "wherein after a single inhalation from the inhalation system, diketopiperazine in a subject's plasma has an AUC greater than 2,300 ng*min/mL per mg of the diketopiperazine content in the dry powder formulation."}2. The inhalation system of claim 1 , wherein the container is removable from the dry powder inhaler.3. The inhalation system of claim 1 , wherein the container is reconfigurable in the dry powder inhaler from a containment configuration to a dosing configuration.4. The inhalation system of claim 1 , wherein the dry powder inhaler is a breath powered inhaler.6. The inhalation system of claim 1 , wherein the diketopiperazine has a Tof less than 1 hour.7. The inhalation system of claim 1 , wherein the dry powder formulation includes an active ingredient.8. The inhalation system of claim 7 , wherein the active ingredient is a peptide claim 7 , polypeptide claim 7 , protein claim 7 , or a combination thereof.9. The inhalation system of claim 7 , wherein the active ingredient is insulin claim 7 , glucagon-like peptide 1 claim 7 , oxyntomodulin claim 7 , peptide YY claim 7 , exendin claim 7 , heparin claim 7 , calcitonin claim 7 , felbamate claim 7 , sumatriptan claim 7 , parathyroid hormone claim 7 , growth hormone claim 7 , erythropoietin claim 7 , AZT claim 7 , DDI claim 7 , granulocyte macrophage colony stimulating factor claim 7 ...

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14-11-2013 дата публикации

Methods, Devices And Formulations For Targeted Endobronchial Therapy

Номер: US20130298904A1

The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

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14-11-2013 дата публикации

NOVEL PROPELLANT CONTAINING PREPARATIONS FOR TIOTROPIUM

Номер: US20130302260A1
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to a novel propellant-gas-containing medicament composition based on tiotropium 1, processes for the preparation thereof and the use of such medicament compositions in the treatment of respiratory complaints. 1. A pharmaceutically active substance tiotropium (1) containing medicament formulation for treatment of inflammatory or obstructive respiratory complaints , the medicament formulation containing as an active substance exclusively (1) in dissolved form , and further contains:(a) the propellant gas HFA 134a;(b) 0.005-0.03% of the active substance (1);(c) a mixture of the two cosolvents ethanol and water, the ethanol content being between 15-40% and the water content being between 0.5-2.5%, and(d) an acid, which is present in an amount such that the pH is between 6 and 8.2. The pharmaceutically active substance tiotropium (1) containing medicament formulation according to claim 1 , wherein the acid is an organic acid.3. The pharmaceutically active substance tiotropium (1) containing medicament formulation according to claim 2 , wherein the organic acid is citric acid in a concentration of between 0.005-0.1%.4. The pharmaceutically active substance tiotropium (1) containing medicament formulation according to claim 1 , wherein the acid is an inorganic acid in a concentration that corresponds to a quantity of H ions that can be obtained by the addition of a 1-3% proportion of a 0.01 normal acid.5. The pharmaceutically active substance tiotropium (1) containing medicament formulation according to claim 4 , wherein the inorganic acid is aqueous hydrochloric acid in a concentration that corresponds to a quantity of H ions that can be obtained by the addition of a 1-3% proportion of a 0.01 normal acid.6. The pharmaceutically active substance tiotropium (1) containing medicament formulation according to claim 4 , wherein the inorganic acid is aqueous sulfuric acid in a concentration that corresponds to a quantity of H ions that can be ...

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21-11-2013 дата публикации

Low Dose Pharmaceutical Powders for Inhalation

Номер: US20130306069A1
Автор: Hrkach Jeffrey S.
Принадлежит: Civitas Therapeutics, Inc.

The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein. 1. A method of delivering an agent to the pulmonary system of a compromised patient , in a single breath-activated step , comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass , wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of the patient.2. A method of claim 1 , wherein the compromised patient has a peak inspiratory flow rate of about 15 liters per minute.3. A method of claim 1 , wherein the inhaler contains less than 4 milligrams of the mass.4. A method of claim 1 , wherein the mass has a tap density of less than about 0.4 g/cm.5. A method of claim 1 , wherein the mass mean geometric diameter of the mass emitted from the inhaler is between about 3 microns and 15 microns.6. A method of claim 1 , wherein the mass mean geometric diameter of the mass emitted form the inhaler is between about 3 microns and 10 microns.7. A method of claim 1 , wherein the mass mean aerodynamic diameter of the mass emitted from the inhaler is between about 1 and 5 microns.8. A method of claim 1 , wherein the mass mean aerodynamic diameter of the mass emitted from the inhaler is between about 1 and 3 microns.9. A method of claim 1 , wherein the emitted dose from the inhaler is greater than about 70%.10. A method of claim 1 , wherein the mass consists essentially of spray-dried particles.11. A method of claim 1 , wherein the inhaler comprises: a first casing portion; a cylindrical chamber claim 1 , defined ...

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21-11-2013 дата публикации

AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER

Номер: US20130306070A1
Принадлежит: Norton Healthcare Ltd.

An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor. 1. A method for de-agglomerating dry powder in a breath-actuated dry powder inhaler , comprising:directing a first breath-actuated airflow for entraining a dry powder from an inhaler into a first end of a swirl chamber extending along a longitudinal axis from the first end of the swirl chamber to a second end of the swirl chamber, the first airflow directed in a longitudinal direction;directing a second breath-actuated airflow in a substantially transverse direction into the first end of the swirl chamber such that the first and the second breath-actuated airflows collide and substantially combine;directing a portion of the combined airflows in a spiral path towards the second end of the swirl chamber;delivering all the combined airflows and any dry powder entrained therein through an outlet port in the second end of the swirl chamber to an airflow adaptor; anddirecting a third breath-actuated airflow to the airflow adaptor having by-passed the swirl chamber.2. A method according to further comprising the step of deflecting a portion of the combined airflows off vanes that are non-rotationally fixedly attached to the first end of the swirl chamber and extending at least in part radially outwardly from the longitudinal axis of the chamber claim 1 , wherein each of the vanes has an oblique surface facing at least in part in a direction transverse to the longitudinal axis claim 1 , such that the portion of the combined airflows is ...

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21-11-2013 дата публикации

Aerosol pirfenidone and pyridone analog compounds and uses thereof

Номер: US20130310424A1
Автор: Mark William Surber
Принадлежит: Genoa Pharmaceuticals Inc

Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.

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28-11-2013 дата публикации

INHALER

Номер: US20130312747A1
Принадлежит: VECTURA DELIVERY DEVICES LIMITED

An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. 170-. (canceled)71. An inhaler comprising a housing to receive a single blister having a puncturable lid and containing a dose of medicament for inhalation by a user , a mouthpiece through which a dose of medicament is inhaled by a user , a blister piercing member and , an actuator pivotally mounted to the housing and operable to cause the blister piercing member to puncture the lid of a blister received in the housing such that , when a user inhales through the mouthpiece , an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.72. An inhaler according to claim 71 , wherein the blister piercing member comprises at least two discrete piercing heads operable to pierce a corresponding number of holes in a blister received in the housing claim 71 , the actuator comprising an arm pivotally mounted to the housing at one end and an opening being formed in the arm in the vicinity of each piercing head claim 71 , at least one of said openings forming an airflow inlet into a blister and claim 71 , at least one other of said openings forming an airflow outlet from a blister claim 71 , the mouthpiece including a primary chamber having an outside air inlet in communication claim 71 , via the primary chamber claim 71 , with ...

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05-12-2013 дата публикации

Liquid Droplet Spray Device

Номер: US20130319404A1

A liquid droplet spray device for ejecting a liquid as a spray of droplets has a cartridge () with a nozzle arrangement () to eject droplets, which is vibrated by a piezo element () through the agency of an actuating element (). A resonance chamber is disposed between an inner wall () of the cartridge and the actuating element () such that the cartridge inner wall () is separated by a gap having a length B from the actuating element (), the cartridge inner wall () being cap-shaped and extending along the side surfaces of the actuating element () and being frictionally attached to the side surfaces along a distance A. The resonance chamber () improves the efficiency of transmission of vibrations to the cartridge. 1. A liquid droplet spray device for ejecting a liquid as a spray of droplets , the device comprising:a first part having a nozzle body for containing said liquid, and having liquid outlet means for ejecting liquid from said device, said nozzle body being arranged proximate to said liquid outlet means such that said liquid may exit the device by traversing said liquid outlet means,a second part arranged to receive and hold said first part,a vibrating element arranged to actuate liquid substance in said nozzle body such that the liquid undergoes a vibration and forces the liquid through the outlet means thereby exiting said device as a liquid droplet spray,said spray device further comprising an actuating element arranged between said vibrating element and said first substrate nozzle body, anda cartridge body provided with a cartridge inner wall arranged between said actuating element and said nozzle body for sealing liquid in said first part,said actuating element and said cartridge inner wall being arranged to transmit ultrasound energy generated by vibration of said vibrating element to liquid in said nozzle body, anda resonance chamber positioned between said cartridge inner wall and said actuating element such that said cartridge inner wall is separated ...

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12-12-2013 дата публикации

DELIVERY DEVICE AND METHOD

Номер: US20130327320A1
Автор: Djupesland Per Gisle
Принадлежит: OPTINOSE AS

A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject. 1a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; andan oral outlet unit including at least one substance outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject during the exhalation or attempted exhalation by the subject.. A delivery device for delivering substance to a mucosal surface within the oral cavity of a subject, the device comprising: The present invention relates to a delivery device and method for the delivery of substance, in particular vaccines, but also medicaments, to mucosal surfaces, and in particular lymphoid structures in the oral cavity.Currently almost all vaccines are administered by injection. Whilst injection is effective, the use of needles leads both to contamination and transmission of infectious diseases, the treatment of which incurs very significant costs. This problem arises particularly in developing countries. Also, the current vaccine formulations require the use of expensive cold-chains.It is thus an aim of the present invention to provide a delivery technique which provides for the needleless delivery of vaccines, and indeed medicaments.Vaccination constitutes one of the ...

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19-12-2013 дата публикации

METHOD AND SYSTEM FOR THE ADMINISTRATION OF A PULMONARY SURFACTANT BY ATOMIZATION

Номер: US20130333695A1
Принадлежит:

A method and system according to preferred embodiments of the present invention allows optimizing the dispensing of aerosol medicaments. In particular the system according to a preferred embodiment of the present invention allows the administration of an exogenous pulmonary surfactant to very young patients (e.g. preterm neonates). A catheter conveys atomized surfactant directly to the retro-pharyngeal region in order to increase efficiency of the medicament administration without being invasive: this is particularly important for very young patients, such as pre-term born neonates suffering from neonatal Respiratory Distress Syndrome (nRDS). According to a preferred embodiment of the present invention the catheter is made of biocompatible flexible material (e.g. plastic material). It is possible to couple the catheter with a rigid scaffolding (e.g. metallic) to increase stiffness of the device and to improve easiness of positioning operations. In a preferred embodiment of the present invention the delivery of the atomized medicament is done by means of an air blasting technique. 1. A system for delivering a medicament to a spontaneously breathing patient , comprising:(i) a flexible catheter adapted to reach the retro-pharyngeal region of the patient, the catheter including at least a first channel being adapted to convey in the patient's pharyngeal region a flow of liquid medicament and at least a second channel adapted to convey in the patient's pharyngeal region a pressurized flow of gas;(ii) first pump means connected to a first end of the at least first channel, adapted to create a pressure which pushes the column of liquid medicament towards the second end of the at least first channel;(iii) second pump means connected to a first end of the at least second channel, adapted to create the flow of pressurized gas;so that when the column of liquid medicament and the pressurized gas meet in the pharyngeal cavity, the liquid column is broken into a plurality of ...

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19-12-2013 дата публикации

DRY POWDER INHALER AND SYSTEM FOR DRUG DELIVERY

Номер: US20130338065A1
Принадлежит: MANNKIND CORPORATION

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable. 1. Fumaryl diketopiperazine (FDKP) microparticles comprising a trans-FDKP isomer content of about 45% to about 63%.2. The FDKP microparticles of having a trans-FDKP isomer content of about 53% to about 63%.3. The FDKP microparticles of having a trans-FDKP isomer content of about 50% to about 56%.4. The FDKP microparticles of having a trans-FDKP isomer content of about 54% to about 56%.5. The FDKP microparticles of wherein the FDKP microparticles comprise a drug.6. The FDKP microparticles of having a trans-FDKP isomer content of about 50% to about 56%.7. The FDKP microparticles of wherein the drug is insulin.8. The microparticles of wherein the insulin content is about 3 to about 4 U/mg.9. A dry powder comprising the microparticles of .10. The dry powder of claim 9 , wherein the microparticles have a trans-FDKP isomer content of about 53% to about 63%.11. A method of treating an insulin-related disorder comprising administering the microparticles of to a person in need thereof.12. FDKP microparticles having improved aerodynamic performance that have been prepared by a process comprising:determining the trans-FDKP isomer content;wherein the ...

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26-12-2013 дата публикации

POWDER DISPERSION DEVICES AND METHODS

Номер: US20130340747A1
Автор: Donovan Martin J.
Принадлежит: Respira Therapeutics, Inc.

A dry powder inhaler may include a powder storage, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel. 1. A dry powder inhaler , comprising:a first chamber that is adapted to receive an aerosolized powdered medicament from an inlet channel, wherein volume of the first chamber is greater than volume of the inlet channel;a dispersion chamber that is adapted to receive at least a portion of the aerosolized powdered medicament from the first chamber, the dispersion chamber holding an actuator that is movable within the dispersion chamber along a longitudinal axis; andan outlet channel through which air and powdered medicament exit the inhaler to be delivered to a patient;wherein the geometry of the inhaler is such that a flow profile is generated within the dispersion chamber that causes the actuator to oscillate along the longitudinal axis, thus enabling the oscillating actuator to effectively disperse powdered medicament received in the dispersion chamber for delivery to the patient through the outlet channel.2. The dry powder inhaler of claim 1 , wherein a cross-sectional area of a flow path through the inhaler undergoes a step increase at the entrance to the dispersion chamber.3. The dry powder inhaler of claim 1 , wherein a ratio of the diameter of the dispersion chamber to that of the inlet channel is within a range of about greater than 1.0 to about 3.0.4. The dry powder inhaler of claim 1 , wherein the inlet channel comprises a tube.5. The dry powder inhaler of claim 1 , wherein the inlet channel comprises a tube with a cross-section that varies along the length of the tube.6. The dry powder inhaler of claim 1 , ...

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26-12-2013 дата публикации

POWDER DISPERSION DEVICES AND METHODS

Номер: US20130340754A1
Автор: Donovan Martin J.
Принадлежит:

A dry powder inhaler may include a powder storage, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel. 1. A dry powder inhaler , comprising:a powder storage that is configured to hold a powdered medicament;an inlet channel that is adapted to receive air and powdered medicament from the powder storage;a dispersion chamber that is adapted to receive air and powdered medicament from the inlet channel, the chamber holding an actuator that is movable within the dispersion chamber; andan outlet channel through which air and powdered medicament exit the inhaler to be delivered to a patient;wherein the geometry of the inhaler is such that a flow profile is generated within the dispersion chamber that causes the actuator to oscillate, thus enabling the oscillating actuator to deaggregate the powdered medicament passing through the dispersion chamber to be entrained by the air and delivered to the patient through the outlet channel.2. The dry powder inhaler of claim 1 , wherein a cross-sectional area of a flow path through the inhaler undergoes a step increase at the entrance to the dispersion chamber.3. The dry powder inhaler of claim 1 , wherein a ratio of the diameter of the dispersion chamber to that of the inlet channel is within a range of about greater than 1.0 to about 3.0.4. The dry powder inhaler of claim 1 , wherein the inlet channel comprises a tube.5. The dry powder inhaler of claim 1 , wherein the inlet channel comprises a tube with a cross-section that varies along the length of the tube.6. The dry powder inhaler of claim 1 , wherein the outlet channel comprises a tube with a cross-section that varies along the ...

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02-01-2014 дата публикации

INHALATION DEVICE FOR DRUGS IN POWDER FORM

Номер: US20140000602A1
Принадлежит:

To provide an inhalation device which has improved use properties, particularly advanced moisture protection while in use, an inhalation device () for powder drugs is proposed comprising at least one storage chamber () for accommodating a plurality of drug powder doses and a dosing device which includes at least one dosing slider () which is movable approximately with a translatory movement in a dosing slider passage () at least from a filling position into an emptying position, wherein the inhalation device () further includes a device for inhalation-triggered automatic movement of the dosing slider () from its filling position into the emptying position and a return device for automatic movement of the dosing slider () back into the filling position. 1. An inhalation device for powder drugs comprising at least one storage chamber for accommodating a plurality of drug powder doses and a dosing device which includes at least one dosing slider which is movable approximately with a translatory movement in a dosing slider passage at least from a filling position into an emptying position , wherein the inhalation device further includes a device for inhalation-triggered automatic movement of the dosing slider from its filling position into the emptying position and a return device for automatic movement of the dosing slider back into the filling position.2. An inhalation device according to wherein the dosing slider passage with the at least one dosing slider and the storage chamber is sealed off relative to the environment at least in the filling position of the dosing slider.31. An inhalation device () according to wherein said at least one storage chamber has at least one outlet opening through which the powder drug can issue under the influence of the force of gravity and the dosing slider has at least one dosing cavity claim 1 , wherein the dosing cavity in the filling position is under the outlet opening and the dosing slider is movable out of its filling position ...

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16-01-2014 дата публикации

Compositions for and methods of contrlling olfactory responses to odorants

Номер: US20140017338A1
Принадлежит: AUBURN UNIVERSITY

A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.

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30-01-2014 дата публикации

CAPSULAR MEDICATION DELIVERY AND INHALATION DEVICE

Номер: US20140026887A1
Принадлежит:

A method and capsular medication delivery and inhalation device is used with a medication capsule. The capsule is free-standing in a capsule chamber and not secured in a fixed position. The capsule is moved with a moveable back wall and other cooperative structure into an opener which releases the medication inside the capsule. The device may include an aerosol stream for facilitating medication delivery. The device works with capsules of varying sizes and shapes. 1. A medication delivery device , comprising:a housing;a plurality of capsule chambers radially disposed about a common axis of rotation, the plurality of capsule chambers rotatably connected to the housing;a moveable back wall disposed in each of the plurality of capsule chambers, each moveable back wall configured to move in a direction along the common axis of rotation configured to move a capsule located within each capsule chamber to a position outside each capsule chamber or adjacent to each capsule chamber;a capsule opener attached to the housing; andan incline feature connected to the housing disposed inline with the capsule opener behind the moveable back walls, the incline feature configured to bias at least one of the moveable back walls towards the capsule opener when the plurality of capsule chambers rotates about the common axis of rotation.2. The device of claim 1 , wherein each capsule chamber of the plurality of capsule chambers comprises a first divider wall abutting an outer radius wall claim 1 , the outer radius wall abutting a second divider wall.3. The device of claim 1 , including an opening formed in a portion of the moveable back wall at a common radius to the incline feature claim 1 , the opening configured accept the incline feature without moving the moveable back wall.4. The device of claim 3 , including an opening wall adjacent to the opening configured to prevent the capsule from passing through the opening.5. The device of claim 1 , wherein the moveable back wall is ...

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06-02-2014 дата публикации

NEBULIZER HAVING HORIZONTAL VENTURI

Номер: US20140034051A1
Принадлежит: PNEUMOFLEX SYSTEMS, LLC

In accordance with non-limiting examples, a nebulizer includes a main body comprising an air channel section and further comprising a mixing chamber and a venturi positioned to be placed within the patient's oral cavity and configured to receive medicine and air and mix the medicine and air within the mixing chamber and receive the air flow through the venturi and cause the medicine entering the mixing chamber to be atomized by the action of air flowing through the venturi. An air flow sensor is associated with the main body and configured to measure the air flow created by the patient's one of at least inhaling and exhaling air. 124-. (canceled)25. A nebulizer , comprising: a gas channel that receives a flow of gas;', 'a medicine feed that receives medicine; and', 'a nebulizer outlet configured to be received within the oral cavity of a patient;, 'a nebulizer body comprising'}a mixing chamber formed within the nebulizer body;a longitudinally extending venturi connected to the gas channel and having a venturi outlet at the mixing chamber and the medicine feed terminating thereat, wherein said venturi is configured to be oriented horizontally when the nebulizer is in use and to receive and mix the medicine and gas at the venturi outlet and within the mixing chamber and to atomize the medicine by the action of gas flowing through the venturi and into the mixing chamber during nebulization and exit the nebulizer outlet into the oral cavity of the patient.26. The nebulizer according to claim 25 , and further comprising at least one medicine receiver contained on the nebulizer body and connected to said medicine feed to deliver medicine within the medicine feed.27. The nebulizer according to claim 26 , wherein the at least one medicine receiver is configured to receive a unit dosage of medicine.28. The nebulizer according to claim 26 , and further comprising a plurality of medicine receivers carried by the nebulizer body claim 26 , each medicine receiver containing a ...

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13-02-2014 дата публикации

METHOD FOR TREATMENT OF LUNG INFECTIONS BY ADMINISTRATION OF AMINOGLYCOSIDES BY AEROLISATION

Номер: US20140041654A1
Автор: Norling Thomas
Принадлежит: XELLIA PHARMACEUTICALS APS

The present invention regards a novel administration form and a novel administration regime useful in the treatment and prevention of a bacterial lung infection in patient in need thereof, in particular by providing a composition useful for aerosolization of a highly concentrated solution of aminoglycosides such as Tobramycin. 1. A method for preventing or treating bacterial infections in the pulmonary system of a patient in need thereof comprisingadministering by inhalation an aerosolized dose of an aqueous solution of 150-250 mg/ml of an aminoglycoside antibiotic,wherein administering is with a metered dose inhalation device that provides an aerosol having a mass median aerodynamic diameter of 4-7 micrometer,wherein the metered dose inhaler has a spray nozzle unit providing said aerosols by transferring the composition through orifices.2. The method of claim 1 , wherein the aminoglycoside antibiotic is Tobramycin.3. The method of claim 2 , wherein the Tobramycin is Tobramycin sulphate corresponding to 150-250 mg/ml of Tobramycin.4. The method of claim 3 , wherein the Tobramycin is Tobramycin sulphate corresponding to 180 mg/ml of Tobramycin.5. The method of claim 3 , wherein the aqueous solution of 150-250 mg/ml of Tobramycin sulphate is free of added sodium chloride.6. The method of claim 5 , wherein the aqueous solution of Tobramycin sulphate has a pH of 6-8.7. The method of claim 3 , wherein inhalation is performed in less than 5 minutes.8. The method of claim 3 , wherein administering is by breath actuated inhalation and the patient performs 7 inhalations.9. The method of claim 3 , wherein inhalation is performed in less than 4 minutes.10. The method of claim 3 , wherein inhalation is performed in less than 3 minutes.11. The method of claim 3 , wherein inhalation is performed in less than 2 minutes.12. The method of claim 3 , wherein inhalation is performed in less than 1 minute.13. The method of claim 3 , wherein the volume of the dose to be aerosolized is ...

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13-02-2014 дата публикации

NASAL DELIVERY DEVICES

Номер: US20140041660A1
Принадлежит: OPTINOSE AS

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber. 1a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet;a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber;a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; anda moisture-reducing element for reducing condensation at or downstream of the container chamber.. A nasal delivery device for delivering substance to a ...

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13-02-2014 дата публикации

DIKETOPIPERAZINE MICROPARTICLES WITH DEFINED SPECIFIC SURFACE AREAS

Номер: US20140045745A1
Принадлежит: MANNKIND CORPORATION

Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin. 1. A method of delivering an active agent to a patient in need thereof comprising administering a dry powder comprising microparticles of a diketopiperazine , the microparticles having a specific surface area of less than or about 67 m/g , the microparticles having been loaded with a drug or active agent , by inhalation of said dry powder by said patient.2. The method of claim 1 , wherein the active agent is an endocrine hormone selected from the group consisting of insulin claim 1 , parathyroid hormone claim 1 , calcitonin claim 1 , glucagon claim 1 , glucagon-like peptide-1 claim 1 , oxyntomodulin claim 1 , and an analog or active fragment of said endocrine hormone.3. The method of claim 1 , wherein the patient has been diagnosed with diabetes.4. The method of claim 1 , in which said specific surface area is from about 35 m/g to about 67 m/g or from about 40 m/g to about 67 m/g.5. An inhalation system comprising a breath powered inhaler and a dry powder comprising microparticles of a diketopiperazine claim 1 , the microparticles having a specific surface area of less than or about 67 m/g.6. The inhalation system of claim 5 , in which said specific surface area is from about 35 m/g to about 67 m/g or from about 40 m/g to about 67 m/g.7. The inhalation system of wherein said dry powder is provided in a unit dose cartridge.8. The inhalation system of wherein said dry powder is provided prefilled in the inhaler.9. The inhalation system of wherein said inhaler has a resistance to flow of from approximately 0.065 (√kPa)/liter per minute to about 0.200 (√kPa)/liter per minute.10. The inhalation system of wherein said inhaler has a flow path passing through an area of powder containment and a flow path bypassing said area of powder containment claim 5 , ...

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20-02-2014 дата публикации

Small-Volume Nebulizers and Methods of Use Thereof

Номер: US20140048062A1
Автор: Faram Joseph Dee
Принадлежит:

The invention relates to a small-volume nebulizer with a valve system to provide lung physiotherapy during airway therapy with small-volume nebulizers. The valve system may be incorporated into a small-volume nebulizer. The small-volume nebulizer may be pre-filled with at least one unit-dose of medicine and hermetically sealed until use. The nebulizer may be sealed at the top with a removable cap that may be detached at the time of use and replaced with a patient connector. Likewise, the nebulizer may be sealed at the bottom with a bottom cap that is replaced with a gas source at the beginning of a therapeutic aerosol treatment. 1. A pre-filled , small-volume nebulizer comprising: an aerosolizing chamber, wherein contained within said aerosolizing chamber is at least one of a siphon, a jet, and a baffle,', 'a chimney at the top of said aerosolizing chamber, wherein contained within said chimney is a valve gate which, during operation of the small-volume nebulizer by a user, opens with an inhalation by the user and closes with an exhalation by the user;', 'a patient interface tube at the top of said chimney, wherein the patient interface tube includes a patient opening operable to connect with a patient interface component and an ambient port operable to connect with a flow restrictor, and', 'an inlet opening operable to connect with a gas input;, 'a small-volume nebulizer body comprisinga first seal removably engaged with said patient opening;a second seal removably engaged with said inlet opening;a third seal removably engaged with said ambient port; anda unit-dose of medication contained within said small-volume nebulizer body.2. The apparatus according to claim 1 , wherein said patient interface component comprises a mouthpiece.3. The apparatus according to claim 1 , wherein said medication is a first component of a multi-component medication claim 1 , further including a first compartment containing a second component of said multi-component medication.4. The ...

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27-02-2014 дата публикации

Methods, Devices And Formulations For Targeted Endobronchial Therapy

Номер: US20140053830A1

The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. 1. A method of treating an antibiotic-resistant infection , comprising: a) identifying an intubated subject with an antibiotic-resistant infection; and b) administering an aerosolized antibiotic to said subject under conditions such that said antibiotic-resistant infection is eliminated.2. The method of claim 1 , wherein said conditions comprise delivering said aerosolized antibiotic with a device claim 1 , said device comprising a vibrational element and a dome-shaped aperture plate.3. The method of claim 1 , wherein said conditions comprise delivering the aerosolized antibiotic so that said aerosol first contacts said subject at said subject's trachea.4. The method of claim 3 , wherein aerosolized antibiotic is delivered to the trachea and deep lung.5. The method of claim 1 , wherein a reduction of antibiotic-resistant organisms are ...

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27-02-2014 дата публикации

VENTILATOR AEROSOL DELIVERY SYSTEM

Номер: US20140053831A1
Принадлежит: Philip Morris USA Inc.

A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for receiving carrier gas from a ventilator, which is in communication with a plurality of gas entry ports within the transition adapter. An inner cavity of the transition adapter receives the aerosol from the heated capillary and the streams of carrier gas from the plurality of gas exit ports within the transition adapter and directs the streams of carrier gas at least partially encircling and in parallel with the aerosol. An exit port on the distal end of the transition adapter housing delivers an entrained aerosol to an aerosol delivery connector. 1. An aerosol transition adapter for delivering an aerosolized active agent to a patient , the aerosol transition adapter comprising:a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a source of aerosol comprising an aerosolized active agent and the distal end having an exit port, the housing having a length between the distal end and the proximal end;a carrier gas connection port for receiving a carrier gas from a gas source, which is in communication with a plurality of carrier gas exit ports, the plurality of carrier gas exit ports are arranged adjacent to the aerosol passage in a pattern that partially encircles the flow of aerosol;an inner cavity, which is adapted to receive the aerosol from the aerosol passage and the carrier gas from the plurality of carrier gas exit ports and to direct streams of carrier gas to at least partially encircle and flow in parallel with a main direction of a flow of the aerosol along the length of the housing toward the exit port; andthe exit port on the distal end of the housing for delivering the aerosol to a ...

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27-02-2014 дата публикации

Gas dispenser with diffusing nosepiece

Номер: US20140053835A1
Принадлежит: Capnia Inc

Described here are hand-held, low flow devices for dispensing a therapeutic gas. The devices may be configured to include a gas control assembly for delivering a defined volume of gas at a controlled pressure and flow rate. A nosepiece may be included in the device that is formed of a porous material capable of filtering the dispensed gas, and also diffusing the flow of gas as it travels through the nosepiece and into the nasal cavity. The nosepiece may be configured so that there is substantially no restriction of flow therethrough. Methods for treating various medical conditions and delivering therapeutic gases to the nasal mucosa using hand-held, low flow gas dispenser devices are also described.

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06-03-2014 дата публикации

AEROSOL INHALATION DEVICE

Номер: US20140060531A1
Принадлежит: CHIESI FARMACEUTICI S.p.A.

Actuators for an aerosol inhalation device containing a housing adapted to receive an aerosol canister containing a pressurized medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block and an orifice and a tubular element extending in the mouthpiece portion from the orifice aperture in a longitudinal axis substantially aligned with a longitudinal axis of the mouthpiece portion provide a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. In addition the presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 μm. 1. An actuator for an aerosol inhalation device , comprising:a housing adapted to receive an aerosol canister containing a pressurized medicament formulation, provided with a metering valve having a hollow valve stem;a mouthpiece portion terminating in a mouthpiece opening through which the user inhales;a nozzle block defining a valve stem receptacle, an expansion chamber or sump, and an orifice, with an aperture, to propel an aerosol formulation toward said mouthpiece opening; and,a tubular element extending in said mouthpiece portion from said orifice aperture in a longitudinal axis substantially aligned with a longitudinal axis of said actuator mouthpiece portion and substantially coinciding with the longitudinal axis of said orifice.2. An actuator according to claim 1 , wherein said tubular element is configured such that one of its terminal openings may be close fit to said nozzle block external surface claim 1 , around said orifice aperture claim 1 , so as to be in a continuous flow path with said orifice and to enclose said orifice aperture within a recess.3. An actuator ...

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06-03-2014 дата публикации

NASAL DEVICES

Номер: US20140060536A1
Автор: Djupesland Per Gisle
Принадлежит: OPTINOSE AS

A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit. 1. A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a plurality of interface units attached to a support, each interface unit comprising (i) at least one nosepiece unit for fitting to a respective nostril of a subject and comprising a nozzle from which substance is in use delivered, and (ii) at least one delivery unit comprising a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit; and an actuation unit to which the interface units are successively attached for actuating the at least one delivery unit of each respective interface unit, the actuation unit comprising an advance mechanism configured to automatically or semi-automatically advance each interface unit in turn to a position with the actuation unit, whereby the at least one delivery unit is in a position to be actuated to deliver substance to the nozzle. The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject, in particular for the mass treatment, especially vaccination, of subjects.Referring to , the nasal airway comprises the two nasal cavities separated by the nasal septum, ...

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20-03-2014 дата публикации

Nozzle and inhaler and method for producing a nozzle

Номер: US20140076308A1
Автор: Stephen Terence Dunne

A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed. The nozzle comprises two holes formed in a flat plate. Then, the plate is deformed such that the axes of the holes intersect so that jets of fluids generated by the holes impinge with each other.

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20-03-2014 дата публикации

Indicating device

Номер: US20140076312A1
Принадлежит: Individual

A dispenser for dispensing metered dosages of a substance from a container includes a dispenser housing having a top, a bottom, and a wall defining an elongated cavity open at the top and extending along a longitudinal axis. An indicating device includes a face member defining a viewing window. The face member is snap-fitted to the dispenser housing wall. The indicating device further includes an indicator member having a surface visible through the viewing window. The surface includes dosage indicia. The indicator member is rotatable about an axis substantially perpendicular to the longitudinal axis. An indicator actuator has at least a portion disposed in the cavity. The actuator is adapted to be moved by an actuation of the container, with the actuator adapted to rotate the indicator member upon a predetermined number of actuations of the container.

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20-03-2014 дата публикации

Metering Device for the Inhalation of a Pulverulent Substance

Номер: US20140076313A1
Принадлежит: Siegfried Generics International AG

A metering device activated by a user induced airstream for an inhalation of a medicinal substance. The device includes: a closure cap; a piston; a mouthpiece; and an annular chamber disposed upstream of the mouthpiece. A storage chamber stores the substance which can be moved out of the storage chamber when the closure cap is removed. A metering rod for removing the medicinal substance out of the storage chamber into an emptying-standby position. In the emptying-standby position, the metering chamber is closed by the piston. The piston is displaceable by airstream into an emptying-release position. In the emptying-release position, a metering chamber is released and the substance removed by the suction airstream. The metering device includes an outer cylinder which accommodates an inner cylinder. 121-. (canceled)22. A metering device activated by a user induced airstream for an inhalation of a medicinal substance , the metering device comprising:a closure cap;a piston;a mouthpiece;an annular chamber disposed upstream of said mouthpiece;a storage chamber storing said medicinal substance which can be moved out of said storage chamber when said closure cap is removed; [ 'said piston being displaceable by said airstream into an emptying-release position,', 'in said emptying-standby position, said metering chamber being closed by said piston,'}, 'in said emptying-release position, said metering chamber being released and said substance removed by said suction airstream;, 'a metering rod comprising a metering chamber for removing said medicinal substance out of said storage chamber into an emptying-standby position,'}wherein the metering device comprises an outer cylinder which accommodates an inner cylinder.23. The metering device according to claim 22 ,wherein said metering rod passes through a center of said inner cylinder.24. The metering device according to claim 23 ,wherein in a cap closed position, a hollow cylinder of said closure cap passes through said center ...

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27-03-2014 дата публикации

DRY POWDER INHALER AND SYSTEM FOR DRUG DELIVERY

Номер: US20140083421A1
Принадлежит: MANNKIND CORPORATION

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable. 1. A method of treatment using a dry powder medicament to be delivered to the pulmonary tract with a dry powder inhalation system , comprising:opening a dry powder inhaler having a mouthpiece;loading a cartridge comprising a pre-metered dose of a dry powder medicament in a containment configuration;closing the inhaler to reconfigure the cartridge to a dosing configuration; andinhaling once through the mouthpiece to deliver the dry powder medicament in a single inhalation.2. The method of wherein the dry powder medicament comprises an active agent.3. The method of wherein the active agent comprises at least one of a synthetic organic compound claim 2 , a protein claim 2 , a peptide claim 2 , a sugar claim 2 , a lipid claim 2 , an inorganic compound claim 2 , or a nucleic acid sequence.4. The method of wherein the dry powder medicament comprises a microparticle.5. The method of wherein the microparticle comprises a diketopiperazine.6. The method of wherein the diketopiperazine has the formula 2 claim 5 ,5-diketo-3 claim 5 ,6-di(4-X-aminobutyl)piperazine claim 5 , wherein X is selected from the group consisting of fumaryl claim 5 , succinyl ...

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27-03-2014 дата публикации

INHALER

Номер: US20140083422A1
Принадлежит:

A dry powder inhaler comprises a disc-shaped assembly () having cavities () filled with medicament powder for inhalation. The assembly is rotatably mounted in a housing () on which is mounted a rotatable external casing (). A mouthpiece () is movably mounted on the housing () allowing it to be brought into and out of engagement with the edge of the disc () whereby the mouthpiece acts as a brake to prevent or permit rotational movement of the disc (). The inhaler is opened by rotating the housing with respect to the casing () to expose the mouthpiece (). As the inhaler is opened and closed, cam followers () on the mouthpiece move along cam tracks () in the casing (), causing the mouthpiece to move against or away from the disc (). A gap is defined between the disc and mouthpiece to allow a flow of bypass air to enter the mouthpiece. 1. An inhaler comprising:a housing and a mouthpiece mounted on the housing, the mouthpiece having an inhalation channel,a disc shaped assembly comprising a plurality of compartments containing medicament, the disc assembly being rotatably mounted to the housing to allow medicament-containing compartments to be brought sequentially into registry with the mouthpiece, the mouthpiece being located at or beyond the outer periphery of the disc assembly and being in communication with the disc assembly via an aperture in the housing,an indexing mechanism associated with the disc assembly,wherein the mouthpiece is movably mounted with respect to the housing and the mouthpiece forms part of the indexing mechanism.2. An inhaler as claimed in wherein the mouthpiece is a brake claim 1 , being movable between (i) a braking position in which it is engaged with the disc assembly and the disc assembly is thereby prevented from rotating and (ii) a released position in which it is disengaged from the disc assembly.3. An inhaler as claimed in wherein the mouthpiece includes a spacing member which extends towards the disc assembly and is engaged with a notch ...

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27-03-2014 дата публикации

TECHNIQUES FOR EVALUATING URINARY STRESS INCONTINENCE AND USE OF INVOLUNTARY REFLEX COUGH AS A MEDICAL DIAGNOSTIC TOOL

Номер: US20140088375A1
Принадлежит: PNEUMOFLEX SYSTEMS, LLC

A system permits diagnosis of a patient for a physiological abnormality while protecting their airway. An esophageal airway protection device comprises an elongate device body having a distal end for insertion into the stomach through the esophagus and a proximal end. The device includes a main lumen extending the length of the device and an inflatable esophageal cuff carried by the device body mid-esophagus. Emesis and/or reflux is blocked from passing out of the stomach past the esophageal cuff positioned mid-esophagus when it is inflated to protect a patient's airway during an involuntary cough event. At least one electromyogram (EMG) pad is configured to obtain an EMG from an involuntary cough activated paraspinal muscles. A processing device is configured to receive the EMG and process the EMG to determine a physiological abnormality. 118-. (canceled)19. A system of diagnosing a patient for a physiological abnormality comprising:an esophageal airway protection device that comprises an elongate device body having a distal end for insertion into the stomach through the esophagus and a proximal end, and an expandable esophageal blocking device carried by the device body, wherein upon expansion of said esophageal blocking device, emesis and/or reflux is blocked from passing out of the stomach past the esophageal blocking device;a nebulizer through which medication is delivered for administering an involuntary cough event;at least one electromyogram (EMG) pad configured to obtain an EMG from involuntary cough activated paraspinal muscles; anda processing device configured to receive the EMG and process the EMG to determine a physiological abnormality.20. The system according to claim 19 , and further comprising at least one pressure sensor carried by the device body and configured to measure intra-abdominal pressure (IAP) claim 19 , wherein said processing device receives the IAP and correlates the IAP and EMG.21. The system according to claim 20 , wherein the said ...

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10-04-2014 дата публикации

Nasal Aroma Breathing Pipe

Номер: US20140096767A1
Автор: Scott Pearson
Принадлежит: Individual

The claimed invention is an apparatus to assist and encourage a person to take long, deep and steady breaths. The invention is designed to provide improved health for the user by fostering; improved breathing and relaxation, positive smell association, calmer clearer thinking, reduced stress and anxiety, as well as providing a substitute for potentially harmful habits such as smoking, over-eating, over-drinking and other forms of drug abuse. This invention may also reduce the impact of some existing physiological and psychological health conditions.

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10-04-2014 дата публикации

Dose counters for inhalers, inhalers and methods of assembly thereof

Номер: US20140096769A1
Принадлежит: Norton Waterford Ltd

A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

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10-04-2014 дата публикации

SALT PUFFER

Номер: US20140096770A1
Принадлежит:

An inhaler/puffer is provided. The inhaler/puffer may comprise a body, a cap, and a base, the cap and the base being configured to functionally engage the body. The body may define a chamber wherein minerals, such as salt, may be housed. The body, cap, and base may be configured to permit a user to inhale on the cap and draw air through the base into the chamber, over the minerals, through the cap and into the respiratory system of the user. Additionally, the inhaler/puffer may be placed in-line with an oxygen breathing system, such that as the breathing system provides oxygen to the user, the user also receives salt air treatment. 1. An inhaler , the inhaler comprising:a tubular body having a first region and a second region, the tubular body defining a chamber between the first region and the second region, the chamber being configured to house a dry material therein;a cap having a first end and a second end, the first end comprising an opening, the second end being open and configured to be releasably coupled to the tubular body at the first region;a base configured to be releasably coupled to the tubular body at the second region, the base being configured to permit fluidic communication through the base and into the chamber; anda filter member within the tubular body and configured to permit fluidic communication between the chamber and the cap.2. The inhaler of claim 1 , wherein the filter member is fixedly coupled to sidewalls of the body between the first region and the second region and is configured to prevent the dry material from entering the cap.3. The inhaler of claim 1 , wherein the cap tapers from the second end to the first end.4. The inhaler of claim 1 , wherein the base is comprised of synthetic material and the cap and the base are each comprised of high density rubber.5. The inhaler of claim 1 , wherein the dry material is crystalline salt.6. The inhaler of claim 1 , wherein the cap is configured to be removed from the inhaler without releasing ...

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06-01-2022 дата публикации

Device and method for aerosolized delivering of substance to a natural orifice of the body

Номер: US20220001118A1
Принадлежит: SIPNOSE Ltd

A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

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01-01-2015 дата публикации

Device For Administering A Powdered Medicament To A Patient By Inhalation

Номер: US20150000656A1
Автор: Stefan Mayer
Принадлежит: SANOFI SA

A device ( 1 ) for administering a powdered medicament to a patient by inhalation is described. The device ( 1 ) comprises a body ( 2 ), an internal housing ( 3 ) in the body ( 2 ), an inhalation channel ( 4 ), a mouthpiece ( 5 ), and a dose provisioning member ( 6 ). The dose provisioning member ( 6 ) comprises at least one cavity ( 7,7 a, 7 b, 7 c ) for accommodation of a powdered medicament, the dose provisioning member ( 6 ) further being enabled to adopt a first position in which the cavity ( 7,7 a, 7 b, 7 c ) is out of alignment with the inhalation channel ( 4 ) and a second position in which the cavity ( 7,7 a, 7 b, 7 c ) is in alignment with the inhalation channel ( 4 ). Each cavity ( 7,7 a, 7 b, 7 c ) is prefilled with a single dose ( 8,8 a, 8 b, 8 c ) of a powdered medicament, wherein the powdered medicament is solely stored in each cavity ( 7,7 a, 7 b, 7 c ) and the device ( 1 ) is free of a powder reservoir for storing a plurality of doses. A protective member ( 9 ) is provided within the housing ( 3 ), the protective member ( 9 ) being enabled to adopt a first position in which a part of the protective member ( 9 ) lies in the inhalation channel ( 4 ) such that the cross-section of the inhalation channel ( 4 ) is covered by a wall of the protective member ( 9 ) and to adopt a second position in which the protective member ( 9 ) does not lie in the inhalation channel ( 4 ) such that the cross-section of the inhalation channel ( 4 ) is not covered by a wall of the protective member ( 9 ).

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01-01-2015 дата публикации

INHALATION DEVICE FOR POWDERED DRUGS

Номер: US20150000657A1
Принадлежит: Almirall, S.A.

The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key () acting on said transportation mechanism when pressed by the patient. Said dosage key () while being pressed is only temporarily engaged with said transportation mechanism such that a metering cycle while be completed and the transportation mechanism and/or the metering means will be reset even if said dosage key () will be held in depressed condition. 1. Inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream , comprising at least one powder reservoir , metering means for repeatedly metering a powder dose from the reservoir , a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel , at least one activating device for manual operation by the patient , said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered , said activating device comprising a dosage key acting on said transportation mechanism when pressed by the patient , characterized in that said dosage key while being pressed is only temporarily engaged with said transportation mechanism such that a metering cycle will be completed and the transportation mechanism ...

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07-01-2016 дата публикации

DRUG COMBINATION

Номер: US20160000790A1
Принадлежит: Verona Pharma plc

The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist. 1. A composition which comprises (a) a PDE3/PDE4 inhibitor which is 9 ,10-Dimethoxy-2-(2 ,4 ,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3 ,4 ,6 ,7-tetrahydro-2H-pyrimido[6 ,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.2. A composition according to claim 1 , in which the PDE3/PDE4 inhibitor (a) is 9 claim 1 ,10-Dimethoxy-2-(2 claim 1 ,4 claim 1 ,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3 claim 1 ,4 claim 1 ,6 claim 1 ,7-tetrahydro-2H-pyrimido[6 claim 1 ,1-a]isoquinolin-4-one.3. A composition according to claim 1 , in which the muscarinic receptor antagonist (b) is atropine claim 1 , hyoscine claim 1 , glycopyrrolate claim 1 , ipratropium claim 1 , tiotropium claim 1 , oxitropium claim 1 , pirenzepine claim 1 , telenzepine claim 1 , aclidinium or umeclidinium.4. A composition according to claim 1 , in which the muscarinic receptor antagonist (b) is atropine claim 1 , ipratropium bromide or tiotropium bromide.5. A composition according to claim 1 , wherein the composition is a fixed combination.6. A pharmaceutical composition comprising a composition as defined in and one or more pharmaceutically acceptable carriers claim 1 , diluents claim 1 , or excipients.7. A pharmaceutical composition according to which is for administration by dry powder inhaler (DPI) or metered-dose inhaler (MDI).8. A method of treating a disease or condition which is based on (i) acute or chronic obstruction of vessels or bronchi or (ii) acute or chronic inflammation claim 6 , in a subject in need thereof claim 6 , which method comprises administering to said subject (a) a PDE3/PDE4 ...

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07-01-2021 дата публикации

DRUG DELIVERY DEVICE WITH ELECTRONICS AND POWER MANAGEMENT

Номер: US20210001061A1
Принадлежит:

A system may limit the number of times an inhalation device transmits inhalation data to a single time to reduce the battery usage of the inhalation device. The system may include an inhalation device that has medicament and an electronics module. The system may limit the number of times the inhalation device transmits new inhalation data to any mobile device to a single time by causing the server to receive the new inhalation data from one of the mobile devices and causing the server to transmit the new inhalation data to other of the mobile devices prior to the other mobile devices transmitting a request for the new inhalation data to the inhalation device. The inhalation device may include a Quick Response (QR) code, and a mobile application may determine at least one of a medication type or a number of doses of the inhalation device from the QR code. 1. A system comprising:a cloud-based server comprising a processor, memory, and a communication circuit;an inhaler comprising a mouthpiece, medicament, and an electronics module, the electronics module comprising a processor, memory, and a communication circuit; send a request for inhalation data to the inhaler;', 'receive the inhalation data from the inhaler, the inhalation data associated with a timestamp; and', 'transmit the inhalation data and timestamp to the cloud-based server; and, 'a first mobile application residing on a first mobile device, the first mobile device comprising a processor, a communication circuit, and memory, and the first mobile application configured to cause the processor of the first mobile device to transmit a request to the cloud-based server that includes an indication of a last synchronization time between the second mobile application and the inhaler; and', 'receive the inhalation data of the inhaler from the cloud-based server in response to the request, wherein the timestamp associated with the inhalation data is subsequent to the last synchronization time between the second ...

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07-01-2021 дата публикации

DEVICES, SYSTEMS, AND METHODS FOR DELIVERY OF A REPERFUSION-INJURY-MODIFYING DRUG TO A PATIENT

Номер: US20210001062A1
Принадлежит:

Devices and systems for delivering an aerosolized reperfusion-injury-modifying drug (RIMD) to a patient are described. In an embodiment, the devices include an RIMD; an aerosolizer in fluid communication with the RIMD configured to aerosolize the RIMD to provide an RIMD aerosol; and an exit port configured to direct the RIMD aerosol for receipt by the patient. In an embodiment, the systems include a ventilator configured to generate airflow and coupled to the exit port. Methods for delivering an aerosol comprising an RIMD to a patient are also described. In an embodiment, the methods include aerosolizing an RIMD to provide an RIMD aerosol comprising RIMD droplets; and introducing the RIMD aerosol into an inhalation airflow of the patient. 1. A device for delivering an aerosolized reperfusion-injury-modifying drug (RIMD) to a patient , the device comprising:an RIMD;an aerosolizer in fluid communication with the RIMD configured to aerosolize the RIMD to provide an RIMD aerosol; andan exit port configured to direct the RIMD aerosol for receipt by the patient.2. The device of claim 1 , wherein the exit port is configured to couple with a ventilator.3. The device of claim 1 , wherein the exit port is configured to couple with a supraglottic airway or an endotracheal tube.4. The device of claim 1 , wherein the RIMD is a fluorinated anesthetic.5. The device of claim 4 , wherein the RIMD is selected from the group consisting of isoflurane claim 4 , sevoflurane claim 4 , desflurane claim 4 , methoxyflurane claim 4 , and combinations thereof.6. The device of claim 1 , wherein the RIMD is a liquid at room temperature and atmospheric pressure and immiscible with water.7. The device of claim 1 , wherein the aerosolizer is configured to provide the RIMD aerosol including droplets of the RIMD having an average diameter in a range of about 10 μm to about 20 μm.8. The device of claim 1 , wherein the RIMD is mixed with an additive selected from the group consisting of ...

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07-01-2021 дата публикации

DRY POWDER INHALER AND SPACER DEVICE FOR A DRY POWDER INHALER

Номер: US20210001064A1
Принадлежит:

Provided is a Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device () comprising a bag () and a body () including inlet () and opposed outlet (), the inlet () and opposed outlet () being provided on, and integral with, the body (). The body () and bag () combine to form chamber () for operatively receiving vaporised dry powder medication. The inlet () and outlet () each are in the form of a port that is in fluid flow communication with the chamber (). The inlet () and outlet () define, and are separated by, a broad V-formation formed as part of the body (). The body () further includes an elliptical lower perimeter () defining flange (), for demountably receiving bag () 1. A Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device comprising:a body in the form of a generally V-shaped mounting formed by opposing inlet and outlet passages intersecting at an angle of between 30 and 170 degrees along their respective longitudinal axes; anda demountable, flexible bag attached below the body, the bag and body together defining a chamber, such that the inlet and outlet passages are in fluid flow communication with an interior of the chamber;wherein the inlet is configured for operative connection to the DPI containing a drug to be inhaled;wherein the outlet is configured to be operatively received by a user's mouth;wherein the DPI includes expulsion means for expelling a powdered drug from the DPI into the spacer device, said drug encapsulated in the form of a capsule, caplet, or gel covering, said expulsion means including piercing means for piercing said capsule, caplet or gel covering to liberate the powder prior to expulsion from the DPI; andwherein the flexible bag serves as reservoir to allow for the formation of a vapour or particle cloud of the drug to be inhaled therewithin following activation of the DPI, the flexible bag being configured to be at least ...

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07-01-2021 дата публикации

POSITIVE EXHALATION PRESSURE DEVICE

Номер: US20210001067A1
Принадлежит: Solopep Limited

A positive exhalation pressure device () is described. The device () comprises a housing () having an annular chamber (), a chamber inlet () configured to permit air into the chamber, a chamber outlet () configured to permit air out of the chamber, and a mouthpiece () in fluid communication with the chamber inlet. A movable body such as a ball () is disposed in the housing within the annular chamber and configured to revolve around the annular chamber in response to flow of air through the chamber from the chamber inlet to the chamber outlet. The movable body is configured to at least partially block the chamber outlet as it revolves around the annular chamber causing cyclical fluctuations in airflow resistance. 115-. (canceled)16. A device , comprising:a housing including an annular track, an inlet configured to permit air into the annular track, an outlet configured to permit air out of the annular track, and a mouthpiece in fluid communication with the inlet; anda body configured to revolve within and around the annular track in response to flow of air from the track inlet to the track outlet, wherein revolutions of the body around the annular track causes intermittent partial blocking of the outlet, and cyclical fluctuations of airflow resistance.17. The device of claim 16 , wherein the body is a ball.18. The device of claim 17 , wherein the ball is comprised of metal.19. The device of claim 16 , wherein the body is an oval or disk shaped body.20. The device of claim 16 , wherein the outlet is disposed on a top claim 16 , bottom claim 16 , or inner circumferential aspect of the annular track.21. The device of claim 16 , wherein the outlet is not disposed on an outer circumferential aspect of the annular track.22. The device of claim 16 , wherein the inlet and outlet are circumferentially spaced apart by at least 90° based on a path of the body around the annular track.23. The device of claim 16 , wherein the body is configured to block at least 75% of the area ...

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07-01-2016 дата публикации

AEROSOLIZATION SYSTEM WITH FLOW RESTRICTOR AND FEEDBACK DEVICE

Номер: US20160001018A1
Принадлежит:

In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range. 1. An aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system , the aerosolization device comprising:a conduit having a mouthpiece end by which a user may cause an inspiratory flow through the conduit;an aerosol generator in communication with the conduit and comprising a vibratable mesh; and provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit; and', 'provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor., 'a restrictor disposed within the conduit, wherein the restrictor defines a plurality of apertures disposed along an outer periphery of the restrictor, the plurality of apertures being configured to2. The aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system according to claim 1 , the aerosolization device further comprising:an indicator mechanism that indicates to a user a state of a parameter of the inspiratory flow relative to a ...

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07-01-2016 дата публикации

DIRECTIONAL FLOW SENSOR INHALER

Номер: US20160001021A1
Принадлежит:

An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator. 1. An air inhalation device for delivering medicament to a user , said device comprising:an acoustic controller, said acoustic controller including an acoustic sensing element configured to detect air flow around said acoustic sensing element and to produce signals that identify the direction and amplitude of said air flow; anda high frequency vibrator configured for inducing said medicament into said air flow when said signals indicate inhalation by said user.2. An inhalation device as claimed in claim 1 , further comprising an electrostatic plate positioned in said air flow for attracting selected particles of medicament thereto claim 1 , said electrostatic plate being configured to activate when said signals indicate inhalation by said user.3. An inhalation device as claimed in claim 1 , wherein said acoustic controller is adapted to stop the vibration of said high frequency vibrator when said signal indicates inhalation has stopped.4. An inhalation device as claimed in claim 3 , wherein said high frequency vibrator is adapted to turn off and on with amplitude of air flow.5. An inhalation device as claimed in claim 1 , wherein said signals control activation of a timer claim 1 , and said timer tracks cumulative inhalation time.6. An inhalation device as claimed in claim 5 , wherein said timer is adapted to provide feedback to said user when cumulative inhalation time exceeds a predetermined level.7. An inhalation device as claimed in claim 1 , wherein acoustic sensing element comprises an acoustic microphone element.8. An inhalation device as claimed in ...

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07-01-2016 дата публикации

NASAL DELIVERY

Номер: US20160001022A1
Принадлежит:

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece. 181-. (canceled)82. A method of fitting a nasal delivery device to a nostril of a subject , the method comprising:inserting a nosepiece of the nasal delivery device into one of the nostrils of the subject, with the nasal delivery device having a first alignment;twisting the nosepiece in the nostril so as to rotate the nasal delivery device to have a second alignment different from the first alignment; andsealing a nare of the nostril against the nosepiece.83. The method of claim 82 , further comprising:applying a grip-enhancing agent to an exterior surface of a nose of the subject.84. The method of claim 82 , wherein the nosepiece comprises a tip element.85. The method of claim 84 , wherein the tip element is substantially elliptical.86. The method of claim 84 , Wherein the tip element is substantially rectangular.87. The method of claim 84 , wherein the tip element comprises a delivery aperture.88. The method of claim 84 , wherein the tip element is tapered.89. The method of claim 82 , wherein the nasal delivery device comprises a delivery unit and a nose gripping member.90. The method of claim 89 , wherein the nose gripping member is tethered to a body of the nasal delivery ...

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05-01-2017 дата публикации

DRY POWDER INHALATION DEVICE

Номер: US20170000960A1
Автор: RICHARDSON Eric Carl
Принадлежит: Concentrx Pharmaceuticals, Inc.

Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient. 1. An apparatus , comprising:a body having an upper portion and a lower portion, the body defining a toroidal disaggregation chamber, a bottom portion of the toroidal disaggregation chamber being within the lower portion and containing a dry powder drug;a removable partition disposed between the upper portion and the lower portion, the partition retaining the dry powder drug within the bottom portion of the toroidal disaggregation chamber when the upper portion and lower portion are coupled together;an air intake passage configured to place an external volume in fluid communication with the toroidal disaggregation chamber when the partition is removed; andan exit passageway configured to place the external volume in fluid communication with the toroidal disaggregation chamber when the partition is removed such that upon inhalation by the patient on the exit passageway, air is drawn from the air intake passage to the toroidal disaggregation chamber and on to the exit passageway to convey the dry powder drug via the exit passageway to a patient.2. A method of using a single-dose inhalation device to deliver a pre-metered dry powder drug , comprising:removing a protective overwrap packaging from the inhalation device;removing a partition of the inhalation device by pulling an end of the partition ...

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05-01-2017 дата публикации

DOSE COUNTER FOR INHALER HAVING A BORE AND SHAFT ARRANGEMENT

Номер: US20170000961A1
Принадлежит:

A dose counter for an inhaler, the dose counter having a display tape arranged to be incrementally driven from a tape stock bobbin onto an incremental tape take-up drive shaft, the bobbin having an internal bore supported by and for rotation about a support shaft, at least one of the bore and support shaft having a protrusion which is resiliently biased into frictional engagement with the other of the bore and support shaft with longitudinally extending mutual frictional interaction. 1. A dose counter for an inhaler , the dose counter having a display tape arranged to be incrementally driven from a tape stock bobbin onto an incremental tape take-up drive shaft , the bobbin having an internal bore supported by and for rotation about a support shaft , at least one of the bore and support shaft having a protrusion which is resiliently biased into frictional engagement with the other of the bore and support shaft with longitudinally extending mutual frictional interaction.2. A dose counter as claimed in in which the support shaft is forked and resilient for resiliently biasing the support shaft and bore into frictional engagement.3. A dose counter as claimed in in which the support shaft has two forks claim 2 , each having a radially extending protrusion having a friction edge extending therealong parallel to a longitudinal axis of the support shaft for frictionally engaging the bore of the support shaft with longitudinally extending frictional interaction.4. A dose counter as claimed in in which the bore is a smooth substantially circularly cylindrical bore.5. An inhaler as claimed in which has a medicament canister mounted thereto.6. An inhaler as claimed in in which the canister comprises a pressurised metered dose canister having a reciprocally movable stem extending therefrom and movable into a main canister body thereof for releasing a metered dose of medicament under pressure.7. An inhaler as claimed in in which the canister is operable by pressing by hand on the ...

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05-01-2017 дата публикации

DOSE COUNTER FOR INHALER HAVING AN ANTI-REVERSE ROTATION ACTUATOR

Номер: US20170000962A1
Принадлежит:

An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler. 1. An inhaler for metered dose inhalation , the inhaler comprising:a main body having a canister housing,a medicament canister, which is moveable relative to the canister housing and retained in a central outlet port of the canister housing arranged to mate with a canister fire stem of the medicament canister, anda dose counter having an actuation member having at least a portion thereof located in the canister housing for operation by movement of the medicament canister,wherein the canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall,wherein the canister housing has a longitudinal axis X which passes through the center of the central outlet port, andwherein the first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.2. The inhaler as ...

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05-01-2017 дата публикации

INHALER

Номер: US20170000963A1
Автор: Hearn Alex, McDerment Iain
Принадлежит:

An inhaler comprising a reservoir of an inhalable composition with an outlet at one end through which the inhalable composition is discharged. A non-metered breath-activated valve is provided between the one end and the reservoir, the breath-activated valve comprising a flow path extending from the reservoir to the outlet end. At least a portion of the flow path is a deformable tube. A clamping member pinches the deformable tube closed when no suction force is applied to the device and releases the tube to open the flow path when suction is applied at the outlet, to provide uninterrupted flow from the reservoir to the outlet. 1. An inhaler comprising:a reservoir of an inhalable composition;an outlet at one end through which the inhalable composition is discharged;a fill valve at the opposite end to the one end and via which the reservoir can be filled; anda non-metered breath-activated valve between the one end and the reservoir, the breath-activated valve comprising a flow path extending from the reservoir to the outlet end, at least a portion of the flow path being a deformable tube, and a clamping member which pinches the deformable tube closed when no suction force is applied to the inhaler and releases the tube to open the flow path when suction is applied at the outlet, to provide uninterrupted flow from the reservoir to the outlet;wherein from the one end to the opposite end, the following components are arranged in order: the outlet, the clamping member, the reservoir, and the fill valve.2. The inhaler of claim 1 , wherein the fill valve is located at the opposite end to the one end.3. The inhaler of claim 1 , wherein the fill valve is at least partially disposed within a housing of the inhaler.4. The inhaler of claim 1 , wherein the clamping member is configured so that a degree of opening of the flow path is proportional to the strength of the suction.5. The inhaler of claim 1 , wherein a wall of the deformable tube is thinner where the clamping member ...

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02-01-2020 дата публикации

SMART SPACER FOR AN INHALER

Номер: US20200001026A1
Принадлежит:

A spacer is provided comprising a chamber having an interior surface and an exterior surface. The interior surface is configured to receive aerosolized medicament from an inhaler and has at least one sensor for measuring airflow in the chamber. The spacer includes an actuator disposed on the exterior surface configured to initiate measurement of airflow in the chamber. Methods of making and using a spacer are also provided. 1. A spacer comprising a chamber having an interior surface and an exterior surface , the interior surface of the chamber configured to receive aerosolized medicament from an inhaler and having at least one sensor for measuring airflow in the chamber; and an actuator disposed on the exterior surface of the chamber configured to initiate measurement of airflow in the chamber.2. The spacer of claim 1 , wherein the interior surface of the chamber is configured to hold aerosolized medicament from the inhaler in the chamber.3. The spacer of claim 1 , wherein the interior surface of the chamber is configured to receive inhaled air and exhaled air from a patient.4. The spacer of claim 1 , wherein the inhaler is a metered dose inhaler (MDI) or a soft mist inhaler (SMI).5. A spacer comprising a chamber having an interior surface and an exterior surface claim 1 , the interior surface of the chamber configured to receive inhalation air and exhalation air from a patient claim 1 , the interior surface having at least one sensor for measuring airflow in the chamber; and an actuator disposed on the exterior surface of the chamber configured to initiate measurement of airflow in the chamber.6. The spacer of claim 5 , wherein the chamber comprises a proximal end opening and a distal end opening claim 5 , and the at least one sensor is disposed adjacent to the proximal end opening.7. The spacer of claim 6 , wherein the proximal end opening comprises a mouthpiece or a mask and the mouthpiece or the mask is configured for engagement with a mouth of the patient claim ...

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02-01-2020 дата публикации

Metered-Dose Inhaler Security System

Номер: US20200001027A1
Принадлежит:

Security features for an electronic metered-dose smart inhaler, mobile app, and cloud-based software system for use with medical prescriptions and clinical trial regimens. The smart inhaler requires several types of user validation and feedback, and enters a locked-out state when required user feedback is not received or when received user feedback raises a suspicion of fraudulent or improper use. While the smart inhaler system is well suited for aerosol medical marijuana products, it may be used to deliver and conduct clinical trials on any type of product suitable for aerosol administration including other types of medication and non-medical products, such as nicotine, herbal products, pain killers, sleep aids, dietary stimulants, dietary suppressants, etc. The security features are not limited to aerosol inhalers, and may be applied more widely to other types of in-home, patient-administered products. 1. An electronic metered-dose inhaler system including security features comprising a cartridge , a pump unit , and a mobile app , wherein: a canister containing pressurized contents for aerosol dispensing without burning or vaporizing the contents of the canister,', 'a mouthpiece unit holding the canister against a spring biasing the canister in a retraction direction allowing the canister to be reciprocated between the retraction direction and an opposing insertion direction to dispense a portion of the contents of the canister through the mouthpiece unit each time the canister is reciprocated,, 'the cartridge comprises a pump actuator positioned to reciprocate the canister to dispense the contents of the canister through the mouthpiece unit when the cartridge is attached to the pump unit in the operational configuration;', 'a battery powering a microprocessor, a memory, and a wireless radio;', 'wherein the memory is operative for storing the security information and associated security procedures;', 'wherein the microprocessor is operative for unlocking the pump ...

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03-01-2019 дата публикации

ACCESSORY DEVICE FOR METERED DOSE INHALER AND METHODS OF USE

Номер: US20190001080A1
Автор: OKADIGWE Cyril
Принадлежит:

An accessory device for use with a hand-held metered dose inhaler (MDI), comprising: a housing, sized and shaped to mount the MDI therein; a movement mechanism configured to cause compressive movement of at least one piece of the housing to activate the MDI; and, at least one side-mounted movement actuator operationally connected to the movement mechanism to instigate the movement. 1. An accessory device for use with a hand-held metered dose inhaler (MDI) , comprising:a housing, sized and shaped to mount the MDI therein;a movement mechanism configured to cause compressive movement of at least one piece of the housing to activate the MDI; and,at least one movement actuator, mounted on a side of the housing, operationally connected to the movement mechanism to instigate the movement.2. An accessory device according to claim 1 , further comprising a fastener removably attachable to the housing and at least partially enclosing the MDI to retain the MDI within the housing.3. An accessory device according to claim 2 , wherein the fastener is a fastening strap.4. An accessory device according to claim 1 , wherein the housing comprises a header and a lower body.5. An accessory device according to claim 4 , wherein the lower body is moveably disposed in at least one channel of the header claim 4 , such that initiation of the movement actuator causes the lower body to move relative to the header by sliding in the channel.6. An accessory device according to claim 5 , wherein the at least one side-mounted movement actuator is mounted on the housing at a pivot point.7. An accessory device according to claim 5 , wherein the at least one side-mounted movement actuator is provided with at least one tooth configured as a counterpart to at least one groove in the header claim 5 , such that engagement of the groove by the tooth effectuates movement of the lower body relative to the header.8. An accessory device according to claim 6 , wherein the at least one side-mounted movement ...

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03-01-2019 дата публикации

FLOW GOVERNORS FOR USE IN MEDICINAL INHALERS

Номер: US20190001081A1
Принадлежит:

A flow governor for use in a medicinal inhaler. The flow governor can include (i) a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and (ii) an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly. 1. A flow governor for use in a medicinal inhaler , the flow governor comprising:a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; andan internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.2. The flow governor of claim 1 , wherein the tubular element is substantially bistable between an uncollapsed state and a collapsed state.3. The flow governor of claim 1 , wherein the internal support structure is rigid relative to the tubular element claim 1 , and the tubular element is flexible relative to the internal support structure.4. The flow governor of claim 1 , wherein the internal support structure has a base having an outer wall claim 1 , and wherein an end of the tubular element is stretched over the outer wall of the base of the internal support structure.5. The flow governor of claim 1 , wherein the internal support structure includes at least one hollow pillar claim 1 , and wherein the air flow path through the flow governor includes a space between an outer wall of the internal support structure and the tubular element claim 1 , and a space within the at ...

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03-01-2019 дата публикации

WEARABLE AEROSOL INHALER DEVICE AND METHOD

Номер: US20190001082A1
Принадлежит:

A wearable inhaler includes a wristband closed by at least one separation joint. The wristband is flexible or hinged to open between a first end and a second end at the at least one separation joint. An operable inhaler is disposed within the first end. In an open configuration, a partially exposed section and a mouth piece are exposed to provide a metered dose of aerosol to a user. A method of use of a wristband inhaler is also described. 1. A wearable inhaler comprising:a wristband closed by at least one separation joint, said wristband flexible or hinged to open between a first end and a second end at said at least one separation joint; andan operable inhaler disposed within said first end, wherein in an open configuration, a partially exposed section and a mouth piece are exposed to provide a metered dose of aerosol to a user.2. The wearable inhaler of claim 1 , wherein a longitudinal axis of said operable inhaler is aligned about axially or co-axially within said wristband.3. The wearable inhaler of claim 1 , wherein said mouth piece comprises at least one bite pad.4. The wearable inhaler of claim 1 , wherein said second end provides a protective cover for said operable inhaler disposed within said first end.5. The wearable inhaler of claim 1 , wherein said operable inhaler comprises a single dose inhaler.6. The wearable inhaler of claim 1 , wherein said operable inhaler comprises a multiple dose inhaler.7. The wearable inhaler of claim 1 , wherein said operable inhaler comprises a re-fillable inhaler.8. The wearable inhaler of claim 7 , wherein said operable inhaler comprises a trap refill door.9. The wearable inhaler of claim 7 , wherein said operable inhaler comprises a filling valve.10. The wearable inhaler of claim 1 , wherein said operable inhaler comprises an actuator slidably coupled to a housing shell.11. The wearable inhaler of claim 10 , wherein said operable inhaler comprises a backboard about flush against a back of an outer casing.12. The wearable ...

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03-01-2019 дата публикации

AEROSOL GENERATION WITH REDUCED SOUND GENERATION

Номер: US20190001083A1
Автор: HIJLKEMA MARKUS
Принадлежит:

The present invention relates to generating aerosols. In order to provide an improved aerosol generation with enhanced user friendliness, an aerosol generator () is provided that comprises an aperture structure () comprising a plurality of apertures, a transducer (), a reservoir space () for receiving a liquid, from which liquid droplets are to be generated in order to produce an aerosol, and a control unit (). The reservoir space is arranged adjacent to the aperture structure. The transducer is configured to generate a vibrational movement to be transferred as a relative movement between the liquid and the aperture structure. The control unit is configured to activate the transducer to vibrate for a first period having a first time to generate a relative movement between a liquid and the aperture structure, the movement being in a transverse direction to the aperture structure to urge liquid through the plurality of apertures to produce a plurality of droplets; and to pause the transducer for a second period having a second time; and to continuously repeat the activation and pause in an alternating manner. The control unit is further configured to randomly vary at least the second time for a following repeat loop at least after a determined maximum number of repetitions. 1. An aerosol generator comprising:an aperture structure comprising a plurality of apertures;a transducer;a reservoir space for receiving a liquid, from which liquid droplets are to be generated in order to produce an aerosol; anda control unit;wherein the reservoir space is arranged adjacent to the aperture structure; and wherein the transducer is configured to generate a vibrational movement to be transferred as a relative movement between the liquid and the aperture structure; wherein the control unit is configured to:activate the transducer to vibrate for a first period having a first time to generate a relative movement between a liquid and the aperture structure, the movement being in a ...

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