15-01-2015 дата публикации
Номер: US20150013695A1
Принадлежит:
Described herein are compositions, methods and an apparatus relating to the pulmonary delivery of an inhalable composition comprising caffeine, or a salt thereof, and a solvent selected from the group consisting of propylene glycol, glycerol, ethanol and a combination thereof. 1. An inhalable composition , comprising caffeine , or a salt thereof , and a solvent selected from the group consisting of propylene glycol , glycerol , ethanol and a combination thereof.2. The inhalable composition of claim 1 , wherein the composition comprises propylene glycol and glycerol claim 1 , and the composition has a ratio of propylene glycol to glycerol of about 2:1 to about 1:2.3. The inhalable composition of claim 1 , wherein the composition is a vapor comprising liquid droplets.4. The inhalable composition of claim 3 , wherein the liquid droplets have an average diameter of about 1 micron to about 10 microns.5. The inhalable composition of claim 1 , wherein the composition further comprises an additive selected from the group consisting of yerba mate leaf extract claim 1 , huperizine claim 1 , taurine claim 1 , inositol claim 1 , niacinamide claim 1 , phenylalanine claim 1 , citicoline claim 1 , or a salt of any thereof claim 1 , and a combination thereof.6. The inhalable composition of claim 5 , wherein the composition comprises:about 1 wt. % to about 10 wt % caffeine HCl,about 1 wt. % to about 10 wt % yerba mate leaf extract,{'sup': −10', '−5, 'about 1×10wt. % to about 1×10wt % huperizine,'}about 1 wt. % to about 30 wt % taurine,about 1 wt. % to about 30 wt % inositol,about 0.1 wt. % to about 3 wt % niacinamide,about 1 wt. % to about 30 wt % phenylalanine,about 1 wt. % to about 30 wt % citicoline,about 1 wt. % to about 30 wt % propylene glycol, andabout 1 wt. % to about 30 wt % glycerol.7. The inhalable composition of claim 6 , wherein the composition comprises:about 3.8 wt % caffeine HCl,about 2.5 wt % yerba mate leaf extract,{'sup': '−8', 'about 1×10wt % huperizine,'}about 9 ...
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