04-01-2018 дата публикации
Номер: US20180000859A1
Принадлежит:
The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack. 1. A method for improving organ or tissue function or organ or tissue transplant longevity , comprising: administering carbon monoxide (CO)-containing gas a plurality of times to a patient in need of therapy , at a constant alveolar concentration for at least about 30 minutes.2. The method of claim 1 , wherein the patient is a transplant recipient claim 1 , optionally selected from kidney claim 1 , liver claim 1 , lung claim 1 , pancreas claim 1 , heart claim 1 , bone marrow claim 1 , and intestine.3. The method of or claim 1 , wherein the patient is experiencing or is at risk of acute rejection claim 1 , chronic allograft rejection claim 1 , vascular rejection claim 1 , or graft versus host disease (GVHD).4. The method of or claim 1 , wherein the patient has a condition selected from a chronic kidney fibrosing condition claim 1 , a chronic hepatic fibrosing condition claim 1 , a chronic lung fibrosing conditions claim 1 , myocardial fibrosis claim 1 , pancreatic fibrosis claim 1 , pancreatitis claim 1 , gastrointestinal fibrosis or strictures claim 1 , vascular fibrosis or strictures claim 1 , progressive systemic sclerosis (PSS) claim 1 , scleroderma claim 1 , esophageal fibrosis or strictures claim 1 , cirrhosis claim 1 , atrial fibrosis claim 1 , Crohn's Disease claim 1 , Inflammatory Bowel Disease claim 1 , paralytic ileus claim 1 , arthritis claim 1 , arthrofibrosis claim 1 , and nephrogenic systemic fibrosis.5. The ...
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