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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 14695. Отображено 100.
15-03-2012 дата публикации

Isoform nell-1 peptide

Номер: US20120065574A1
Автор: Chia Soo, Kang Ting
Принадлежит: UNIVERSITY OF CALIFORNIA

This application generally relates to an isoform Nell-1 peptide, compositions thereof, and methods of using the same.

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Номер записи: 1
03-05-2012 дата публикации

Transdermal Fluid Delivery Device

Номер: US20120109065A1
Автор: Larry P. Backes
Принадлежит: TYCO HEALTHCARE GROUP LP

A transdermal fluid delivery device includes a housing defining a longitudinal axis and having a proximal end and a distal end. The housing defines a passageway extending longitudinally therethrough. A fluid reservoir is disposed at the proximal end of the housing in communication with the passageway of the housing and is adapted for retaining a fluid therein. A base member is positioned at the distal end of the housing. A microneedle assembly including a plurality of microneedles extending distally therefrom is also provided. The microneedle assembly is selectively moveable with respect to the housing between a retracted position, wherein the microneedles are disposed within the housing, and an extended position, wherein the microneedles are advanced distally to penetrate the base member and extend distally therefrom for puncturing the patient's epidermis and delivering the fluid into the patient's bloodstream.

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Номер записи: 2
10-05-2012 дата публикации

Drug delivery medical devices

Номер: US20120116305A1
Автор: John E. Papp
Принадлежит: Abbott Cardiovascular Systems Inc

Medical devices for delivering a bioactive agent and methods of use thereof are provided. The medical devices include micro-needles integrated within a balloon of a catheter. The balloon can include dimples, cavities or a variable thickness membrane in which the micro-needles are integrated.

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Номер записи: 3
20-09-2012 дата публикации

Methods of electric field induced delivery of compounds, compositions used in delivery, and systems of delivery

Номер: US20120238943A1
Автор: Jun Ge, Richard N. Zare
Принадлежит: Leland Stanford Junior University

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like.

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Номер записи: 4
27-09-2012 дата публикации

Glucose Monitoring System

Номер: US20120245445A1
Автор: Anita Margarette Chambers, Michael Darryl Black, Trent Huang
Принадлежит: Individual

A body fluid sampling system for use on a tissue site includes a drive force generator and one or more microneedles operatively coupled to the drive force generator. Each of a microneedle has a height of 500 to 2000 μm and a variable tapering angle of 60 to 90°. A sample chamber is coupled to the one or more microneedles. A body fluid is created when the one or more microneedles pierces a tissue site flows to the sample chamber for glucose detection and analysis.

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Номер записи: 5
01-11-2012 дата публикации

Systems and methods for collecting fluid from a subject

Номер: US20120277697A1
Автор: Donald E. Chickering, III, Li Yang Chu, Mark Michelman, Ramin Haghgooie, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device.

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Номер записи: 6
08-11-2012 дата публикации

Method of molding a microneedle

Номер: US20120280428A1
Автор: Dennis E. Ferguson, Donald L. Pochardt, Satinder K. Nayar
Принадлежит: 3M Innovative Properties Co

A method of molding a microneedle including providing a mold apparatus having a mold insert having the negative image of at least one microneedle, a compression core, a mold housing configured to allow a reciprocal motion between the mold insert and the compression core. The method includes placing the mold apparatus in a closed position, injecting polymeric material into the closed mold apparatus, compressing the injected polymeric material between the mold insert and the compression core by a reciprocal motion between the compression core and the mold insert, opening the mold, and removing a molded microneedle from the mold. The mold insert has a mold insert height and the molded microneedle has a height that is from about 90% of the mold insert height to about 115% of the mold insert height.

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Номер записи: 7
27-12-2012 дата публикации

Micro-needle device

Номер: US20120330250A1
Автор: Kazuya Machida, Seiji Tokumoto, Tetsuji Kuwahara
Принадлежит: Hisamitsu Pharmaceutical Co Inc

An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 μm including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm 2 is applied to the micro-needle device 1 which is in contact with the skin.

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Номер записи: 8
21-03-2013 дата публикации

Device having array provided with fine protrusions

Номер: US20130072874A1
Автор: Seiji Tokumoto, Shuji ISHITSUKA, Toshiyuki Matsudo
Принадлежит: Hisamitsu Pharmaceutical Co Inc

An array 1 provided with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0<(a/b)≦7.5 holds.

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Номер записи: 9
04-04-2013 дата публикации

Low-pressure packaging for fluid devices

Номер: US20130081960A1
Автор: Kevin Schott
Принадлежит: Seventh Sense Biosystems Inc

Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can “leak” into the device and alter the pressure of any vacuum chambers that may be contained therein.

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Номер записи: 10
30-05-2013 дата публикации

Skin Permeation Device for Analyte Sensing or Transdermal Drug Delivery

Номер: US20130137951A1
Автор: Debashis Ghosh, HAN Chuang, James P. Hurley, Juan P. Eslava, Keith Krystyniak, Scott C. Kellogg
Принадлежит: Echo Therapeutics Inc

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece. The abrasive tip can be made of any material with a surface that can abrade skin. The material can be conductive or non-conductive. The controlled abrasion device may be provided in a kit, where the kit contains the device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time. The desired level of skin impedance, and thus the resulting permeability of the treated site, can be set at a predetermined value. Alternatively, the level of skin impedance can be selected based on the desired level of skin integrity, the subject's sensation of discomfort, or the duration of the application. The device contains a control mechanism which uses an appropriate algorithm or signal processing on the conductivity information provided by the electrodes to determine when the desired level of skin permeability has been reached. Once the desired ...

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Номер записи: 11
30-05-2013 дата публикации

Delivering and/or receiving fluids

Номер: US20130138058A9
Автор: A. David Boccuti, Christopher J. Morse, Donald E. Chickering, III, Greg Fisher, Javier Gonzalez-Zugasti, Maisam Dadgar, Mark Michelman, Ramin Haghgooie, Richard L. Miller, Scott James, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

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Номер записи: 12
06-06-2013 дата публикации

Devices, systems and methods for magnetic-assisted therapeutic agent delivery

Номер: US20130139832A1
Автор: Benjamin Shapiro, Isaac B. Rutel
Принадлежит: Individual

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.

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Номер записи: 13
20-06-2013 дата публикации

Delivering and/or receiving material with respect to a subject surface

Номер: US20130158468A1
Автор: Donald E. Chickering, III, Howard Bernstein, Ping Gong, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.

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Номер записи: 14
27-06-2013 дата публикации

Self-injection device having needle cover with activation preventer

Номер: US20130165866A1
Автор: Corey Christensen
Принадлежит: Becton Dickinson and Co

A drug delivery device, including a body ( 104, 116 ) having a reservoir ( 160 ) disposed therein for containing a medicament and an injection needle ( 152 ) for penetrating the skin of a patient, the needle ( 152 ) providing a path for the medicament between the reservoir ( 160 ) and the patient. The device also includes a rotor ( 580 ) rotatably disposed in the body ( 104, 116 ) for activating the device upon rotation of the rotor ( 580 ), a needle cover ( 112 ) for covering the injection needle, and a needle cover clip ( 560 ) disposed on the needle cover ( 112 ) to rotate from a first position preventing rotor rotation to a second position permitting rotor rotation.

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Номер записи: 15
11-07-2013 дата публикации

Devices for transdermal drug delivery

Номер: US20130178830A1
Автор: Dewan Fazlul Hoque Chowdhury
Принадлежит: NDM Technologies Ltd

A transdermal drug delivery device comprises needles or other means for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. Means are provided for applying the carriers to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

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Номер записи: 16
15-08-2013 дата публикации

Micro-needle coating method

Номер: US20130209660A1
Автор: Hidetoshi Hamamoto, Katsunori Kobayashi, Takurou Kurita, Yuji Makino
Принадлежит: MedRx Co Ltd, Teijin Ltd

Since all methods of applying a drug liquid to a tip portion of a microneedle are application of the drug liquid in an open system, evaporation of the solvent from the drug liquid is unavoidable, such that the concentration of the drug liquid changes easily, and a large amount of the drug liquid is necessary. The invention provides a method of applying a drug to a pin-frog-shaped microneedle by using a small amount of the solution and without variation of the concentration of the drug liquid. A member having plural grooves is produced, and one end thereof is immersed in a drug liquid tank to fill the grooves with the drug liquid. The drug can be uniformly applied to a tip portion of the microneedle by setting the pin-frog-shaped microneedle to pass through the drug liquid in the grooves.

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Номер записи: 17
12-12-2013 дата публикации

Micro-needle bladder balloon

Номер: US20130331783A1
Автор: Carrie Lee Herman, Kari L. Cierzan, Natalie Ann Borgos
Принадлежит: AMS Research LLC

Devices and methods for delivering treatment fluids or particulates such as, stem cells, drugs, Botox and like, to an inner lining of a bladder for treatment of urinary tract disorders, including over active bladder. A balloon delivery system can include an inflation balloon having a plurality of micro-needles configured to pierce and otherwise puncture an inner bladder wall so as to deliver the treatment fluid to bladder tissue. The treatment fluid can be directly injected into the bladder tissue using the micro needles. Alternatively, the micro needles can be fabricated of bioabsorbable or bioresorbable materials such that the micro needles can remain embedded within the bladder tissue to deliver the treatment fluid or particulate.

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Номер записи: 18
26-12-2013 дата публикации

Skin Treatment Device

Номер: US20130345661A1
Автор: Franklin J. CHANG
Принадлежит: Individual

A device and methods for increasing the permeability of the skin's surface to fluid and/or drug delivery is described. The device comprises an abrasive media to remove the outer layer of the stratum corneum, while at the same time applying an electric current that stimulates the skin under the stratum corneum, and delivers fluids from a supply reservoir. The device may also have a vacuum function which evacuates fluid and skin debris from the surface of the skin and delivers the evacuated fluid and skin debris to a waste (or collection) container.

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Номер записи: 19
20-02-2014 дата публикации

Apparatus for physiological and environmental monitoring with optical and footstep sensors

Номер: US20140051948A1
Автор: Jesse Berkley Tucker, Michael Edward Aumer, Steven Francis Leboeuf
Принадлежит: Valencell, Inc.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

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Номер записи: 20
03-04-2014 дата публикации

Apparatus, systems and methods for monitoring and evaluating cardiopulmonary functioning

Номер: US20140094663A1
Автор: Jesse Berkley Tucker, Michael Edward Aumer, Steven Francis Leboeuf
Принадлежит: Valencell, Inc.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

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Номер записи: 21
06-01-2022 дата публикации

Acupressure medallion, method and device for its manufacture and method of reduction of pain from acupressure reflexotherapy

Номер: US20220000711A1
Автор: Roman BURKO, Tymur BURKO
Принадлежит: Individual

The acupressure element includes a base with spiked applicators and an additional layer of low-melting substance, which creates a surface flush with the points of the spiked applicators. The layer hides the points and prevents pain. During a reflexotherapy procedure, the layer of low-melting material melts, either under the influence of human body heat or with the use of external heating. The points of the spiked applicators are gradually released and begin to press on the skin. The pressure on the skin does not occur immediately, allowing to prepare for increased pain later and acclimate accordingly.

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Номер записи: 22
07-01-2021 дата публикации

DENTAL ANESTHETIC DELIVERY DEVICE

Номер: US20210000579A1
Автор: Higdon Norris
Принадлежит:

Disclosed herein is a dental anesthetic delivery device. The dental anesthetic delivery device may comprise a handle and a body having a trough with a concave, horseshoe-shaped inner cavity. The inner cavity, which may be positioned over and around the area of a painful tooth, may further provide a soft or otherwise non-irritating interior surface which may comprise materials such as mesh, gauze, padding, or similar. The interior surface may act as a carrier of and delivery platform for various dental anesthetic substances. The dental anesthetic delivery device may incorporate a temperature modulation system that allows for the delivery of heat or cold to the affected area. 1. A dental anesthetic delivery device comprising: a cavity wall;', 'an inner cavity bounded by the cavity wall; and', 'a substrate disposed on an interior surface of the cavity wall, wherein the substrate is configured to deliver medicament to an affected area in an oral cavity upon contact with the affected area; and, 'an applicator comprisinga handle coupled to the applicator.2. The dental anesthetic delivery device of claim 1 , wherein the applicator further comprises an accommodation trough dimensioned to accommodate opposing teeth during use of the dental anesthetic delivery device.3. The dental anesthetic delivery device of claim 1 , wherein the substrate comprises at least one of cotton padding claim 1 , mesh claim 1 , gauze claim 1 , microfiber claim 1 , and synthetic fabric.4. The dental anesthetic delivery device of claim 1 , wherein the substrate comprises at least one of a diffusor claim 1 , a jet injector claim 1 , and a microneedle.5. The dental anesthetic delivery device of claim 1 , wherein the cavity wall comprises at least one of polymeric claim 1 , metallic claim 1 , ceramic claim 1 , composite claim 1 , wooden claim 1 , and naturally occurring materials.6. The dental anesthetic delivery device of claim 5 , wherein the cavity wall comprises polymeric material further ...

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Номер записи: 23
04-01-2018 дата публикации

EYE TREATMENT

Номер: US20180000640A1
Автор: NICHAMIN Louis D.
Принадлежит:

Methods and kits for treating or preventing an eye condition or for cleaning an eye area tissue are provided. A method of the invention includes administering an isoprenoidal essential oil to eye area tissue, chafing eye area tissue with an abrasive, and removing the abrasive. A kit according to the invention includes an isoprenoidal essential oil, an abrasive for chafing eye area tissue, and in instruction for use for treating an eye condition or cleansing an eye area tissue. The invention also includes a composition of matter comprising an isoprenoidal essential oil and a plurality of abrasive particles in ophthamologically acceptable base. 1. A method of treating anterior blepharitis , posterior blepharitis , Demodex induced blepharitis , conjunctivitis , dry eye , meibomitis , ocular Demodex infestation , or ocular rosacea in eye area tissue comprising:administering tea tree oil to the eye area tissue; andchafing the eye area tissue with an abrasive.2. The method of wherein the concentration of tea tree oil is about 0.5% (w/w) to about 4% (w/w).3. The method of about the concentration of tea tree oil is about 5% (w/w) to about 50% (w/w).4. The method of wherein chafing eye area tissue comprises chafing a tissue selected from the group consisting of: upper eyelid tissue claim 1 , lower eyelid tissue claim 1 , eyelid margin tissue claim 1 , anterior eyelid margin tissue claim 1 , posterior eyelid margin tissue claim 1 , and eyelash follicle.5. The method of wherein the abrasive comprises abrasive particles have a size from about 1 μm to about 600 μm in a longest dimension.6. The method of wherein the abrasive particles have a size from about 25 μm to less than 300 μm in a longest dimension.7300. The method of wherein the abrasive particles have a size from μm to about 600 μm in a longest dimension.8. The method of wherein chafing the eye area tissue comprises performing a motion selected from the group consisting of rubbing and vibrating the eye area tissue.9. The ...

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Номер записи: 24
02-01-2020 дата публикации

COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS USING LIGHT AND GLUCOSAMINE HYDROCHLORIDE

Номер: US20200000696A1
Автор: Chen Michelle, Fassih Ali, Li Jennifer M., Li Wen-Hwa, Moreira Liliam A., Parsa Ramine, Southall Michael D.
Принадлежит:

The present invention provides compositions, methods and kits for treating skin, which combine administration of glucosamine hydrochloride and red light having a peak wavelength of about 600 nm to about 750 nm, near infrared light having a peak wavelength of about 750 nm to about 1000 nm, or both. 1. A method of increasing the production of hyaluronic acid by skin , comprising topically applying to such skin a topical composition comprising up to about 2 weight percent of glucosamine hydrochloride and exposing said skin to red light having a peak wavelength of about 600 nm to about 750 nm , near infrared light having a peak wavelength of about 750 nm to about 1000 nm , or both , using a light delivery device.2. The method of claim 1 , wherein said skin is exposed to both the red light and the near infrared light.3. The method of claim 1 , wherein the topical composition has a pH of about 3.0 to about 5.5.4. The method of claim 1 , wherein the intensity of the light is below about 20 mW/cm.5. The method of further comprising exposing said skin to ultrasonic energy.6. The method of claim 5 , wherein the light delivery device delivers light and ultrasonic energy.7. A method of treating skin claim 5 , comprising topically applying to skin in need of treatment for signs of skin aging a topical composition comprising up to about 2 weight percent of glucosamine hydrochloride and exposing said skin to red light having a peak wavelength of about 600 nm to about 750 nm claim 5 , near infrared light having a peak wavelength of about 750 nm to about 1000 nm claim 5 , or both claim 5 , using a light delivery device.8. The method of claim 7 , wherein said skin is exposed to both the red light and the near infrared light.9. The method of claim 7 , wherein the signs of skin aging are fine lines and wrinkles.10. The method of claim 7 , wherein the topical composition has a pH of about 3.0 to about 5.5.11. The method of claim 7 , wherein the intensity of the light is below about 20 ...

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Номер записи: 25
07-01-2016 дата публикации

METHODS OF INHIBITING CATARACTS AND PRESBYOPIA

Номер: US20160000707A1
Автор: Mohr Benjamin, MUTHUKUMAR MURUGAPPAN
Принадлежит:

Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins. 1. A method of inhibiting or reversing the progression of cataract formation , presbyopia , or age related degeneration of a crystalline lens in an eye comprisingcontacting the eye with an effective cataract-inhibiting amount of an ophthalmic composition comprising at least one γ-crystallin charge masking agent, [{'sub': '2', 'wherein the reactive group is NH, a succinimide, a carboxylic acid, isocyanate, isothiocyanate, sulfonyl chloride, aldehyde, carbodiimide, acyl azide, anhydride, fluorobenzene, carbonate, N-hydroxysuccinimide ester, imidoester, epoxide and fluorophenyl ester, and'}, 'wherein the molecular bristle is a polyethylene glycol, an alkoxy-polyethylene glycol, or an alkoxypolyethylene glycol having 4 to 200 oxyethylene, alkoxyethylene or aryloxyethylene groups; poly(2-hydroxypropyl)methacrylamide (HPMA); poly(2-hydroxyethyl)methacrylate (HEMA); a ply(2-oxaziline), poly(m-phosphocholine, poly lysine, or poly glutamic acid, the molecular bristle having a molecular weight of 150 to 8000., 'wherein the γ-crystallin charge masking agent is a bifunctional molecule containing a reactive group covalently linked to a molecular bristle,'}25-. (canceled)6. The method of claim 1 , wherein the reactive group is NH claim 1 , N-hydroxysuccinimide or COOH.78-. (canceled)10. The method of claim 1 , wherein the ophthalmic composition is an eye drop or an ophthalmic device.11. The method of claim 10 , wherein the ophthalmic device is a contact lens or a punctal plug.12. The method of claim 1 , wherein the ophthalmic composition is administered by injection claim 1 , iontophoresis or ultrasound enhancement.1314-. (canceled)15. An ophthalmic composition comprising a bifunctional ...

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Номер записи: 26
07-01-2021 дата публикации

TRANSDERMAL PATCH PROVIDING IMPROVED PERMEABILITY AND COMPOSITION

Номер: US20210000754A1
Автор: Rowley Clifford T.
Принадлежит:

A transdermal patch contains a water-based solution containing electrolytes, vitamins, and at least one permeation enhancer. The water-based solution also acts as an adhesive matrix which binds the patch together. The solution is transferred to the body via an embossed release liner. In use, the permeation of electrolytes into the bloodstream improves the body's ability to manage hydration. The permeation enhancer increases the porosity of the skin in contact with the transdermal patch to make possible the permeation of the solution into the body. Critical proportions of solvent, solutes, and permeation enhancers are disclosed which have been found to make permeation of otherwise non-absorbable ingredients possible. 1. A transdermal patch comprising:a backer;an embossed release liner able to contact skin; and water,', 'electrolytes,', 'vitamins,', 'an adhesive agent, and', 'a permeation enhancer comprising menthol., 'an adhesive matrix binding the embossed release liner to the backer, the adhesive matrix containing'}2. The transdermal patch of claim 1 , wherein the permeation enhancer further comprises dimethyl sulfoxide.3. The transdermal patch of claim 1 , wherein the permeation enhancer comprises peppermint oil.4. The transdermal patch of claim 1 , wherein the adhesive matrix comprises between ten percent and thirty percent water.5. The transdermal patch of claim 1 , wherein the adhesive matrix comprises polysorbate 80.6. The transdermal patch of claim 1 , wherein the adhesive agent comprises one or more ofsodium polyacrylate;polyacrylic acid;carboxymethylcellulose; andpovidone.7. The transdermal patch of claim 1 , wherein the backer claim 1 , the embossed liner claim 1 , and the adhesive matrix in combination comprise a perimeter forming a water-drop shape.8. The transdermal patch of claim 1 , wherein the adhesive matrix further comprises an external analgesic.9. The transdermal patch of claim 1 , wherein the transdermal patch comprises a thickness of between 0. ...

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Номер записи: 27
04-01-2018 дата публикации

Compositions, methods and devices for forming implants from injected liquids

Номер: US20180000756A1
Автор: Chandrashekhar P. Pathak
Принадлежит: PATHAK HOLDINGS LLC

A method of forming an implant in the tissue can include: providing an injectable composition having a neat liquid carrier, wherein the neat liquid carrier is substantially liquid at room temperature and/or about body temperature; and injecting the neat liquid solution into the tissue at the rate of 10-12000 injections per minute and/or at an amount of 1.0E-02 ml to 1.0E-16 ml per needle per injection. The neat liquid carrier can be polymeric or non-polymeric. The neat liquid carrier can be biodegradable. The neat liquid carrier can include a viscosity-modifying agent. The injecting can form an implant with area greater than or equal to 5 mm 2 . The neat liquid carrier can be injected at a depth of 10 microns to 5 mm. The neat liquid solution can include a drug or other agent.

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Номер записи: 28
02-01-2020 дата публикации

Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches

Номер: US20200000712A1
Автор: Donald Kellerman, Mahmoud Ameri, Peter C. Schmidt, Peter E. Daddona, Yi Ao
Принадлежит: Zosano Pharma Corp, Zp Opco Inc

Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described.

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Номер записи: 29
07-01-2021 дата публикации

Microneedle-mediated delivery of tolerogenic immunotherapeutics

Номер: US20210000907A1
Автор: Christopher M. Jewell, Emily GOSSELIN, Lisa H. Tostanoski
Принадлежит: UNIVERSITY OF MARYLAND AT COLLEGE PARK

Methods, compositions and kits are provided that include microneedles coated with or formed of antigens to which immune tolerance is desired. Use of the microneedles is demonstrated using glatiramer acetate and animal models of multiple sclerosis. Dose sparing and beneficial polarization of immune responses are demonstrated.

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Номер записи: 30
07-01-2016 дата публикации

SUPRAMOLECULAR MAGNETIC NANOPARTICLES

Номер: US20160000918A1
Автор: CHEN Kuan-Ju, Cheon Jinwoo, Noh Seung-hyun, Tseng Hsian-Rong
Принадлежит:

A supramolecular magnetic nanoparticle (SMNP) can be formed by self-assembly of structural components, binding components, terminating components and at least one magnetic nanoparticle. The SMNP can provide on-demand release of a cargo and act as part of an on-demand drug release system. 1. A supramolecular magnetic nanoparticle (SMNP) comprising:a plurality of structural components each including a plurality of binding elements;at least one magnetic nanoparticle each including a plurality of binding elements;a plurality of binding components each including a plurality of binding regions, wherein each of the binding regions is adapted to bind to a binding element;a plurality of terminating components each including a terminating element , wherein the terminating element is adapted to occupy a binding region; anda cargo;wherein the plurality of terminating components are present in a sufficient quantity relative to the plurality of binding regions of the plurality of binding components to terminate further binding.2. The supramolecular magnetic nanoparticle (SMNP) of claim 1 , wherein said plurality of structural components comprises at least one of a dendrimer claim 1 , branched polyethyleneimide claim 1 , linear polyethyleneimide claim 1 , polylysine claim 1 , polylactide claim 1 , polylactide-co-glycolide claim 1 , polyanhydrides claim 1 , poly-ε-caprolactones claim 1 , polymethyl methacrylate claim 1 , poly(N-isopropyl acrylamide) or polypeptides.3. The supramolecular magnetic nanoparticle (SMNP) of claim 2 , wherein said plurality of structural components comprises a dendrimer.4. The supramolecular magnetic nanoparticle (SMNP) of claim 1 , wherein said plurality of terminating components comprises at least one of polyethylene glycol claim 1 , an adamantane derivative claim 1 , target ligands claim 1 , peptides claim 1 , antibodies or proteins.530500. The supramolecular magnetic nanoparticle (SMNP) of claim 1 , wherein the supramolecular magnetic nanoparticle ( ...

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Номер записи: 31
07-01-2016 дата публикации

Treatment System for Cleaning a Component, in Particular an Implant Part, Contaminated with a Biofilm

Номер: US20160000947A1
Автор: Brodbeck Urs
Принадлежит:

A treatment system () for cleaning a component part contaminated with a biofilm, in particular for cleaning bacterially contaminated surfaces of bone implants or dental implants (), shall enable a particularly effective, locally focused and flexible treatment. For this purpose, the treatment system () according to the invention has a conduction element (), which can be put into electric contact with the component needing treatment and which can be connected to a first pole of an electric supply unit (), and a media cannula () which is provided for supplying a treatment liquid and whose interior is connected in an electrically conductive manner with the second pole of the electric supply unit (). 11201016216. A treatment system () for cleaning a component part contaminated with a biofilm , in particular for cleaning bacterially contaminated surfaces of bone implants or dental implants () , having a conduction element () , which can be put into electric contact with the component needing treatment and which can be connected to a first pole of an electric supply unit () , and having a media cannula () which is provided for supplying a treatment liquid and whose interior is connected in an electrically conductive manner with the second pole of the electric supply unit ().21102. The treatment system () of claim 1 , wherein the conduction element () and the media cannula () are arranged in a common housing.3142404. The treatment system () of claim 1 , wherein the outlet opening () of the media cannula () is provided with a lock () claim 1 , which automatically opens when the outlet opening () is pressed against a surface with a force of more than a predefined minimum value.4142404. The treatment system () of claim 2 , wherein the outlet opening () of the media cannula () is provided with a lock () claim 2 , which automatically opens when the outlet opening () is pressed against a surface with a force of more than a predefined minimum value. The invention relates to a ...

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Номер записи: 32
07-01-2016 дата публикации

COMBINATION THERAPY FOR TREATING CANCER AND METHOD FOR TREATING CANCER USING A COMBINATION THERAPY

Номер: US20160001052A1
Автор: Zucker Shoshanna
Принадлежит:

A combination therapy for treating cancer including a DNA damaging agent deliverable to cancer cells and operatively arranged to activate only under a low oxygen condition and a non-thermal plasma deliverable to cancer cells. The non-thermal plasma and the DNA damaging agent individually and in conjunction promote cell toxicity. 1. A combination therapy for treating cancer , comprising:a DNA damaging agent deliverable to cancer cells and operatively arranged to activate only under a hypoxia condition; and,a non-thermal plasma deliverable to cancer cells;wherein said non-thermal plasma and said DNA damaging agent individually and in conjunction promote cell toxicity.2. The combination therapy for treating cancer as recited in claim 1 , wherein said non-thermal plasma is generated from mixing helium gas and atmospheric gases and ionizing the mixed gases.3. The combination therapy for treating cancer as recited in claim 1 , wherein said DNA damaging agent is tirapazamine.4. The combination therapy for treating cancer as recited in claim 1 , wherein said cell toxicity is achieved via apoptosis.5. The combination therapy for treating cancer as recited in claim 1 , wherein said cell toxicity is achieved via necrosis.6. The combination therapy for treating cancer as recited in claim 1 , wherein said non-thermal plasma is deliverable via a plasma torch.7. The combination therapy for treating cancer as recited in claim 1 , wherein said DNA damaging agent is deliverable via injection.8. The combination therapy for treating cancer as recited in claim 1 , wherein said non-thermal plasma is deliverable via a plasma torch and said cancer is treated with said non-thermal plasma for at least one treatment which lasts for at least 10 seconds.9. The combination therapy for treating cancer as recited in claim 1 , wherein said cancer cells are manipulated to overexpress functional gap junctions.10. The combination therapy for treating cancer as recited in claim 1 , wherein said non- ...

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Номер записи: 33
07-01-2016 дата публикации

DRUG-HOLDING MICRONEEDLE ARRAY AND MANUFACTURING METHOD THEREOF

Номер: US20160001053A1
Автор: KAMIYAMA Fumio, Quan Ying-shu, YAMADA Tomoya
Принадлежит:

The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles. 1. A drug-holding microneedle array comprising:a microneedle array having a microneedle substrate and microneedles, the microneedles being positioned in plural on the microneedle substrate and a tip portion of the microneedles projecting via steps; anda drug held on the tip portion and the steps of the microneedles.2. The drug-holding microneedle array according to claim 1 , wherein a size of edges of the steps is more than 10 μm and less than 100 μm.3. The drug-holding microneedle array according to claim 1 , wherein the size of edges of the steps is more than 14 μm and less than 50 μm.4. The drug-holding microneedle array according to claim 1 , wherein a base material of the microneedles is polymers which are injection-moldable or press-moldable.5. The drug-holding microneedle array according to claim 1 , wherein the base material of the microneedles is at least one selected from a group consisting of nylon claim 1 , polycarbonate claim 1 , polylactic acid claim 1 , copolymer of lactic acid and glycolic acid claim 1 , polyglycolic acid claim 1 , polyethylene terephthalate claim 1 , and cyclic olefin polymer.6. The drug-holding microneedle array according to claim 1 , wherein the base material of the microneedles is water-soluble polymers.7. The drug-holding microneedle array according to claim 6 , wherein the base materials of the microneedles is at least one selected from a group consisting of hyaluronic acid claim 6 , sodium chondroitin sulfate claim 6 , carboxymethyl cellulose sodium salt claim 6 , hydroxypropyl cellulose claim 6 , and dextran.8. The drug-holding microneedle array according to claim 1 , wherein the drug is added with a water-soluble polymer or a mixture of the water-soluble polymer and low ...

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Номер записи: 34
07-01-2021 дата публикации

MOLD FOR MANUFACTURING PERCUTANEOUS ABSORPTION SHEET, AND APPARATUS AND METHOD FOR MANUFACTURING PERCUTANEOUS ABSORPTION SHEET HAVING NEEDLE-LIKE PROTRUSION

Номер: US20210001102A1
Автор: CHAI Satoshi, USA Toshihiro
Принадлежит: FUJIFILM Corporation

Provided are a mold for manufacturing a percutaneous absorption sheet that can be detected from an image, and an apparatus and a method for manufacturing a percutaneous absorption sheet having a needle-like protrusion using the mold. The mold is a mold for manufacturing a percutaneous absorption sheet in which a plurality of needle-like recessed portions are disposed, and the problem is solved by a mold for manufacturing a percutaneous absorption sheet in which the mold has a gray color in which a brightness value in a case where a brightness in an HSL (Hue Saturation Lightness) color space is represented in 256 levels is in a range of 30 or more and 200 or less. 1. A mold for manufacturing a percutaneous absorption sheet in which a plurality of needle-like recessed portions are disposed ,wherein the mold has a gray color in which a brightness value in a case where a brightness in an HSL (Hue Saturation Lightness) color space is represented in 256 levels is in a range of 30 or more and 200 or less.2. The mold for manufacturing a percutaneous absorption sheet according to claim 1 ,wherein the mold has a gray color in which the brightness value is in a range of 75 or more.3. The mold for manufacturing a percutaneous absorption sheet according to claim 2 ,wherein the mold has a gray color in which the brightness value is in a range of 150 or less.4. The mold for manufacturing a percutaneous absorption sheet according to claim 1 ,wherein the mold has a gray color in which a saturation value in a case where a saturation in an HSL color space is represented in 256 levels is in a range of 0 or more and 25 or less.5. The mold for manufacturing a percutaneous absorption sheet according to claim 1 ,wherein the mold includes a transparent resin, a white colorant, and a black colorant.6. The mold for manufacturing a percutaneous absorption sheet according to claim 5 ,wherein a mass ratio between the white colorant and the black colorant is 3:1 to 10:1.7. The mold for ...

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Номер записи: 35
07-01-2021 дата публикации

MANUFACTURING METHOD OF MICRONEEDLE ARRAY

Номер: US20210001103A1
Автор: TAKANO Ikuo
Принадлежит: FUJIFILM Corporation

Provided is a method for manufacturing a microneedle array in which the distal end of a needle-like recessed portion is reliably filled with a drug solution. The problem is solved by a method for manufacturing a microneedle array, including: a positioning adjustment step of adjusting positioning of a mold having a needle-like recessed portion on a front surface, and a drug solution ejection nozzle which ejects a drug solution; a relative movement step of moving the mold and the drug solution ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the drug solution ejection nozzle to coincide with each other in a plan view in a direction parallel to an ejection direction of the drug solution; an ejection step of ejecting the drug solution from the drug solution ejection nozzle toward the needle-like recessed portion; and a suction step of suctioning a rear surface of the mold. 1. A method for manufacturing a microneedle array , comprising:a positioning adjustment step of adjusting positioning of a mold having a needle-like recessed portion on a front surface, and a drug solution ejection nozzle which ejects a drug solution in a first direction;a relative movement step of moving the mold and the drug solution ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the drug solution ejection nozzle to coincide with each other in a plan view in the first direction;an ejection step of ejecting the drug solution from the drug solution ejection nozzle toward the needle-like recessed portion; anda suction step of suctioning a rear surface of the mold.2. The method for manufacturing a microneedle array according to claim 1 , wherein the needle-like recessed portion has an opening diameter of 600 μm or more claim 1 , and an angle of 30.0 degrees or more with respect to a flat portion of the mold claim 1 , andan ejection amount of the drug solution ejected to one ...

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Номер записи: 36
04-01-2018 дата публикации

TOPICAL COOLED DERMAL DEVICE

Номер: US20180001069A1
Автор: Streeter John
Принадлежит: L'OREAL

A dermal device for skincare therapy is provided including: a fluid circuit including a fluid pump and a reservoir; and a dermal interface configured to contact a user's skin, the dermal interface including at least one electrode and part of the fluid circuit having at least one perforation, wherein the electrode(s) is configured to deliver an energy pulse to the contacted skin, wherein the reservoir is configured to hold at least one topical, wherein the fluid pump is configured to pump the least one topical through the fluid circuit and extrude the topical through the dermal interface. 1. A dermal device for skincare therapy comprising:a fluid circuit including a fluid pump and a reservoir; and 'the dermal interface including at least one electrode and part of the fluid circuit having at least one perforation,', "a dermal interface configured to contact a user's skin,"}wherein the electrode(s) is configured to deliver an energy pulse to the contacted skin,wherein the reservoir is configured to hold at least one topical,wherein the fluid pump is configured to pump the least one topical through the fluid circuit and extrude the topical through the dermal interface.2. The dermal device of claim 1 , wherein the perforation is configured to surround the electrode interfacing the skin.3. The dermal device of claim 1 , wherein an energy pulse is applied to the skin configured to reduce a skin impedance claim 1 ,wherein the contacted skin is conditioned for the skincare therapy by a reduction in the skin impedance.4. The dermal device of claim 1 , wherein the topical is chilled claim 1 ,wherein the contacted skin is conditioned for the skincare therapy by a reduction in temperature.5. The dermal device of claim 1 , wherein the dermal interface is configured to be removable.6. The dermal device of claim 1 , including a power source to generate the energy pulse.7. A method for conditioning a user's skin claim 1 , the method comprising:applying a chilled topical and an ...

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Номер записи: 37
04-01-2018 дата публикации

MICRONEEDLE ARRAYS FOR ACTIVE AGENT DELIVERY

Номер: US20180001070A1
Автор: Kaspar Roger L., Speaker Tycho
Принадлежит: TRANSDERM, INC.

The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided. 1. A method of providing visual verification of microneedle placement in a skin surface , comprising ,providing a microneedle array having a plurality of microneedles attached thereto, said microneedles including an indicatorapplying the microneedle array to a skin surface of a subject such that the microneedles are embedded into the skin surface,verifying successful application of the microneedles through observation of the indicator's presence in the skin.2. The method of claim 1 , wherein the indicator is a dye.3. The method of claim 1 , wherein the indicator forms an image on the skin of the subject.4. The method of claim 1 , wherein the indicator is visible when light is shown onto the microneedles.5. The method of claim 1 , wherein the indicator is a fluorophore.6. The method of claim 5 , wherein the flourophore includes fluorescein.7. A system for delivering siRNA to a subject claim 5 , comprising:an amount of a self-delivering siRNA a base, and', 'a plurality of microneedles attached to the base, said microneedles comprising a bioabsorbable/biodegradable material and being and configured to be detached from the base after being embedded in a skin surface., 'a microneedle array, said microneedle array comprising'}8. The system of claim 7 , wherein the microneedles include a plurality of longitudinal channels.9. The system of claim 8 , wherein the self-delivering siRNA are present in the longitudinal channels.10. The system of claim 7 , wherein the bioabsorbable/biodegradable material is selected from the group consisting of polyvinyl alcohol claim 7 , polyvinylpyrrolidone claim 7 , chitin claim 7 , carboxymethyl ...

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Номер записи: 38
04-01-2018 дата публикации

FORCE-CONTROLLED APPLICATOR FOR APPLYING A MICRONEEDLE DEVICE TO SKIN

Номер: US20180001071A1
Автор: Simmers Ryan P.
Принадлежит: 3M INNOVATIVE PROPERTIES COMPANY

An applicator and method for applying a microneedle device to a skin surface. The applicator can include a first portion comprising a microneedle array, and a second portion coupled to the first portion via a connector. The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. The method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state. 1. An applicator for applying a microneedle array to a skin surface , the applicator comprising:a first portion comprising a microneedle array and defining a first major surface from which the microneedle array protrudes, the first major surface configured to be substantially parallel with the skin surface and configured to be positioned toward the skin surface; anda second portion coupled to the first portion via a connector that directly contacts both the first portion and the second portion, the connector configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when an application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first major surface of the first portion that meets or exceeds a threshold application force, the second portion defining a second major surface, the second major surface configured to be positioned toward the skin surface; whereinthe connector provides audible feedback to a user when the threshold ...

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Номер записи: 39
02-01-2020 дата публикации

ANTI-CLOGGING AND ANTI-ADHESIVE MICRO-CAPILLARY NEEDLE WITH ENHANCED TIP VISIBILITY

Номер: US20200001063A1
Автор: Rand Kinneret
Принадлежит:

An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers. 1. A capillary tube comprising:a high contrast color marking located at or about the middle of the capillary tube.2. The capillary tube of claim 1 , wherein the capillary tube has an outer surface and an inner surface claim 1 , with the color marking on the outer surface claim 1 , the color marking comprising one or more color marking reagents suitable for visualizing the capillary tube by a microscope claim 1 , and wherein the one or more color marking reagents adhere to the outer surface of the capillary tube.3. The capillary tube of claim 2 , wherein the color marking reagent comprises nanoparticles claim 2 , and wherein the nanoparticles are modified to minimize binding of biological material to the capillary tube from adsorption of proteins and other cellular components.4. The capillary tube of claim 3 , wherein the nanoparticles are selected from the group consisting of: AuNPs claim 3 , AuAgNPs claim 3 , or a combination thereof.5. The capillary tube of claim 2 , wherein the capillary tube has an outer surface and an inner surface ...

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Номер записи: 40
02-01-2020 дата публикации

THREE-DIMENSIONAL MICROFLUIDICS DEVICES FOR THE DELIVERY OF ACTIVES

Номер: US20200001064A1
Автор: Alary Marc, Dave Vipul, Hopson Peyton, Liu Jan-Joo, Patel Bharat
Принадлежит:

A dermal delivery device includes a film having first and second outwardly facing major surfaces; at least one liquid reservoir contained within the film; at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir; and at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel. 1. A dermal delivery device comprising:(a) film having first and second outwardly facing major surfaces;(b) at least one liquid reservoir contained within the film;(c) at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir;(d) at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel.2. The dermal delivery device of further comprising a sensor.3. The dermal delivery device of wherein the sensor detects an amount of a liquid delivered over time.4. A dermal delivery device comprising:(a) film having first and second outwardly facing major surfaces;(b) a plurality of liquid reservoirs contained within the film;(c) each liquid reservoir being in fluid communication with at least one microfluidic channel having a major transverse dimension between about 100 nm and 0.5 mm disposed within the film;(d) at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with at least one microfluidic channel.5. The dermal delivery device of further comprising a sensor.6. The dermal delivery device of wherein the sensor detects an amount of a liquid delivered over time.7. A transdermal delivery device comprising:(a) film having first and second outwardly facing major ...

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Номер записи: 41
02-01-2020 дата публикации

THREE-DIMENSIONAL MICROFLUIDICS DEVICES FOR THE DELIVERY OF ACTIVES

Номер: US20200001065A1
Автор: Alary Marc, Dave Vipul, Hopson Peyton, Liu Jan-Joo, Patel Bharat
Принадлежит:

A transdermal delivery device includes a film having first and second outwardly facing major surfaces; at least one liquid reservoir contained within the film; at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir; and at least one outlet port associated with at least one microneedle operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel. 1. A transdermal delivery device comprising:(a) film having first and second outwardly facing major surfaces;(b) at least one liquid reservoir disposed within the film;(c) at least one microfluidic channel (having a major transverse dimension between about 100 nm and 0.5 mm) disposed within the film and in fluid communication with the at least one liquid reservoir;(d) at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel;(e) at least one microneedle in fluid communication with the at least one outlet port.2. The transdermal delivery device of further comprising a sensor.3. The transdermal delivery device of wherein the sensor detects an amount of a liquid delivered over time.4. The transdermal delivery device of wherein the at least one liquid reservoir disposed within the film contains Cetirizine HCl or a pharmaceutically equivalent Cetirizine compound in a pharmaceutically acceptable solvent.5. The transdermal delivery device of comprising a total amount of Cetirizine HCl or a pharmaceutically equivalent Cetirizine compound of between about 70 mg and about 100 mg.6. The transdermal delivery device of wherein the at least one liquid reservoir disposed within the film contains an analgesic compound in a pharmaceutically acceptable solvent.7. The transdermal delivery device of wherein the analgesic is ...

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Номер записи: 42
03-01-2019 дата публикации

Drug Device Electroporation System

Номер: US20190001105A9
Автор: Hatran Douglas Phat
Принадлежит: Hydra Vascular LLC

Active Energy Facilitated Drug Delivery platform for delivering therapeutics to biological tissue through electrical conductivity. This delivery method is comprised of an elastic alloy to encase a balloon or drug deposition, where the alloy acts to emit an electric field in aiding and actively allowing the pharmaceutical agent to have enhanced permeation, binding and internalization to cells and the biological matrix. A therapeutic agent is deposited onto a balloon to embody the drug deposition, reservoir whereby the electrical field facilitates the active transfer of a pharmaceutical agent to the target tissue is described. 1. A balloon catheter In which the balloon is messed within an elastic conducting alloy cage , wherein the cage is bonded at both distal and proximal balloon ends with an electrical connection at the proximal taper to conductive elements along the body of the catheter to a proximal connection to an electrical power source , and wherein the working length of the balloon and optionally the cage section are coated with materials comprising a therapeutic bio-active agent and optional excipients.2. The device of in which the elastic conducting alloy is nitinol.3. The device of whereby the electrical conducting field can be provided by en energy generator where one polarity is delivered to the emitter while the opposing polarity is grounded to the surface or body of the Intended target.4. The device of whereby the energy field is primarily voltage driven with low current.5. The device of whereby the power supply delivers a square wave with a voltage range of 0.001 kV to 5 kV.6. The device of claim in which the bio-active agents will comprise the broad classes of anti-neoplastic agents claim 1 , mTOR inhibitors claim 1 , taxanes claim 1 , neurotoxins claim 1 , steroids claim 1 , and non-steroidal anti-inflammatory agents.7. The device of claim 4 , wherein the coating is also comprised of one or more of an organic excipient such as a polymer or oligomer ...

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Номер записи: 43
03-01-2019 дата публикации

MICRONEEDLE AND MICRONEEDLE PATCH

Номер: US20190001108A1
Автор: Ono Ichiro
Принадлежит: LABO JUVERSA CO., LTD.

An object of the present invention is to provide a microneedle and a method for producing the same that are specialized for individual treatment purposes and can efficiently achieve a treatment effect. The microneedle according to the present invention relates to a microneedle including a drug containing layer, an intermediate layer, and a base layer in order from a tip side, wherein a boundary between the drug containing layer and the intermediate layer has a shape protruding toward the intermediate layer, and a thickness of a central portion of the intermediate layer is smaller than a thickness of a peripheral edge portion. The microneedle according to the present invention can be more easily broken in the intermediate layer than the conventional microneedle, thereby allowing the drug containing layer to be placed to properly target a particular area in epidermis or dermis. Also, drug release from the drug containing layer can be accurately controlled by a shape, a coating, or the like of the drug containing layer, and a range of application of treatment using a microneedle patch can be extended. 1. A microneedle comprising a drug containing layer , an intermediate layer , and a base layer in order from a tip side ,wherein a boundary between the drug containing layer and the intermediate layer has a shape protruding toward the intermediate layer.2. The microneedle according to claim 1 , wherein a thickness of a central portion of the intermediate layer is smaller than a thickness of a peripheral edge portion.3. The microneedle according to claim 1 , wherein the boundary between the drug containing layer and the intermediate layer has a dome shape protruding toward the intermediate layer.4. The microneedle according to claim 1 , wherein the intermediate layer has a concave lens shape.5. The microneedle according to claim 1 , wherein the intermediate layer has an annular shape.6. The microneedle according to claim 1 , wherein a breaking strength of the intermediate ...

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Номер записи: 44
03-01-2019 дата публикации

MICROSTRUCTURE FOR TRANSDERMAL ABSORPTION AND METHOD FOR MANUFACTURING SAME

Номер: US20190001109A1
Автор: KIM Jae Soo, KWON Soon Chang, PARK Sang Jin
Принадлежит:

The present invention relates to a microstructure including a biocompatible polymer or an adhesive and to a method for manufacturing the same. The present inventors optimized the aspect ratio according to the type of each microstructure, thereby ensuring the optimal tip angle and the diameter range for skin penetration. Especially, the B-type to D-type microstructures of the present invention minimize the penetration resistance due to skin elasticity at the time of skin attachment, thereby increasing the penetration rate of the structures (60% or higher) and the absorption rate of useful ingredients into the skin. In addition, the D-type microstructure of the present invention maximizes the mechanical strength of the structure by applying a triple structure, and thus can easily penetrate the skin. When the plurality of microstructures are arranged in a hexagonal arrangement type, a uniform pressure can be transmitted to the whole microstructures on the skin. 1. A microstructure comprising a biocompatible polymer or an adhesive , wherein the aspect ratio (w:h) , configured of the diameter (w) of the bottom surface of the microstructure and the height (h) of the microstructure , is 1:5 to 1:1.5 , and the angle of a distal tip is 10° to 40°.2. The microstructure of claim 1 , wherein the biocompatible polymer is at least one polymer selected from the group consisting of hyaluronic acid (HA) claim 1 , carboxymethyl cellulose (CMC) claim 1 , alginic acid claim 1 , pectin claim 1 , carrageenan claim 1 , chondroitin (sulfate) claim 1 , dextran (sulfate) claim 1 , chitosan claim 1 , polylysine claim 1 , collagen claim 1 , gelatin claim 1 , carboxymethyl chitin claim 1 , fibrin claim 1 , agarose claim 1 , pullulan polylactide claim 1 , polyglycolide (PGA) claim 1 , polylactide-glycolide copolymer (PLGA) claim 1 , pullulan polyanhydride claim 1 , polyorthoester claim 1 , polyetherester claim 1 , polycaprolactone claim 1 , polyesteramide claim 1 , poly(butyric acid) claim 1 , ...

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Номер записи: 45
13-01-2022 дата публикации

TRANSDERMAL DELIVERY OF HIGH VISCOSITY BIOACTIVE AGENTS

Номер: US20220008703A1
Автор: Ross Russell F.
Принадлежит:

A device and method for delivery of a bioactive agent across a dermal barrier of a subject. The device including a microneedle with a channel and a plurality of nanostructures and microstructures located on the microneedle. The nanostructures and microstructures are arranged in a fractal-like pattern. A reservoir is in fluid communication with the channel and contains a composition having a viscosity of greater than about 5 centipoise and comprising a bioactive agent. The method includes penetrating a stratum corneum of the subject with the microneedle and transporting a composition through the microneedle at a rate of greater than about 0.4 mg/hr/cm2 based upon the surface area of the microneedle. 1. A device for delivery of a bioactive agent across a dermal barrier , the device comprising:a microneedle and a plurality of nanostructures and microstructures located on the microneedle, the nanostructures and microstructures being arranged in a fractal-like pattern, wherein the microneedle further contains a channel; anda reservoir that is in fluid communication with the channel of the microneedle and that contains a composition having a viscosity of greater than about 5 centipoise and comprising a bioactive agent.2. The device according to claim 1 , wherein the composition includes the bioactive agent in a concentration of greater than about 5 mg/mL.3. The device according to claim 2 , wherein the composition includes the bioactive agent in a concentration of from about 35 mg/mL to about 500 mg/mL.4. The device according to claim 1 , wherein the bioactive agent has a molecular weight of greater than about 100 kDa.5. The device according to claim 1 , wherein the bioactive agent is a protein therapeutic.6. The device according to claim 1 , the composition further comprising one or more pharmaceutically acceptable excipients.7. The device according to claim 6 , wherein the pharmaceutically acceptable excipient comprises a solvent claim 6 , a penetration enhancer claim 6 ...

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Номер записи: 46
01-01-2015 дата публикации

Hand-held device for electrically assisted dermal treatment

Номер: US20150005681A1
Автор: Bruno Gimelli, James N. Doyle
Принадлежит: Swiss Spa System Ltd

The invention relates to a hand-held device for electrically powered skin treatment, whereby current is passed into the skin from an external electric circuit via an electrode ( 20 ) so that active ingredients of a cream applied earlier to the skin can better penetrate into the skin. To aid this effect, a cap ( 9 ) of the device, which functions as an electrode ( 20 ), is provided with a vibrator ( 15 ) so that the electrode ( 20 ) vibrates on the skin, thus working the cream into the skin.

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Номер записи: 47
20-01-2022 дата публикации

Microprojection arrays with microprojections having large surface area profiles

Номер: US20220015782A1
Автор: Mark Anthony Fernance Kendall, Michael CRICHTON
Принадлежит: Vaxxas Pty Ltd

A microprojection array comprising a substrate with a plurality of microprojections protruding from the substrate wherein the microprojections have a tapering hexagonal shape and comprise a tip and a base wherein the base has two substantially parallel sides with a slight draught angle of approximately 1 to 20 degrees up to a transition point at which point the angle increases to from about 20 degrees to about 70 degrees.

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Номер записи: 48
20-01-2022 дата публикации

ISOFORM NELL-1 PEPTIDE

Номер: US20220016206A1
Автор: SOO B. Chia, TING Kang
Принадлежит: The Regents of the University of California

This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis. 1. A method of increasing bone formation or regeneration at or near a bone fracture site in a subject in need thereof , the method comprising increasing the concentration of an ISN-1 gene product at the bone fracture site.2. The method of claim 1 , wherein the increasing concentration of an ISN-1 gene product comprises administering to the bone fracture site with a pharmaceutical composition comprising the ISN-1 claim 1 , a related agent claim 1 , or a combination thereof.3. The method of claim 2 , wherein the pharmaceutical composition further comprising LNell-1 protein claim 2 , a related agent claim 2 , or a combination thereof.4. A method of treating claim 2 , preventing or ameliorating osteoporosis by administering to a bone tissue at a pre-selected site an effective amount of an ISN-1 claim 2 , a related agent claim 2 , or a combination thereof.5. The method of claim 4 , further comprising applying to the pre-selected site a physical force to disperse the ISN-1.6. The method of claim 4 , wherein the administering step comprises:making an incision in the bone tissue at the pre-selected site, anddelivering to the bone tissue at the pre-selected site via the incision.7. The method of claim 4 , wherein the physical force is ultrasound.8. The method of claim 4 , wherein the ISN-1 is formulated into a formulation suitable for a mode of delivery selected from percutaneous injection through intact skin to a site claim 4 , direct injection through a surgically opened site or a trauma site claim 4 , surgical implantation claim 4 , extravascular delivery claim 4 , extravascular injection claim 4 , extravascular catheter based injection claim 4 , intravascular delivery claim 4 , intravascular injection claim 4 , intravascular catheter based injections claim 4 , intravenous delivery claim 4 , ...

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Номер записи: 49
12-01-2017 дата публикации

System and method for increasing organic cell regeneration in a cellular medium

Номер: US20170007373A1
Автор: Bogdan Constantin VLADILA
Принадлежит: Individual

A system for increasing organic cell regeneration in a cellular medium includes an electromagnetic (EN) field generating device adapted to produce a constant EM field of less then 1 mT at a radiation frequency of substantially 7.69 Hz, which comprises at least one coil and is adapted to generate the EM field so that the cellular medium is substantially within the generated EM field. A resonance medium is also provided for locating substantially at or adjacent the cellular medium, wherein the resonance medium comprises a composition which is adapted to resonate at the frequency of The EM field generated by the device, wherein the composition is a biologically active composition containing at least a composition comprising crystalline structure minerals.

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Номер записи: 50
12-01-2017 дата публикации

MICROBUBBLE COMPLEXES AND METHODS OF USE

Номер: US20170007636A1
Автор: Burczak John Donald, Lim Hae Won, Lowery Lisa Anne, Mohan Praveena, Rothman James Edward, Sood Anup
Принадлежит:

The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target. 1. A microbubble complex comprising:a microbubble having an outer shell comprising a mixture of native and denatured albumin and a hollow core encapsulating a perfluorocarbon gas;a therapeutic agent selected from a group comprising a small molecule chemotherapeutic agent, peptide, carbohydrate, oligonucleotide, cytotoxin, protein synthesis inhibitor, or combination thereof;a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand through reaction of a reactive group on said ligand; andwherein the ligand is bound to the outer shell of the microbubble through hydrophobic interactions.2. The complex of wherein the therapeutic agent is an oligonucleotide.3. The complex of wherein the oligonucleotide is a naturally occurring or modified DNA or RNA.4. The complex of wherein the RNA is a small interfering RNA.5. The complex of wherein the bifunctional linker comprises a oligo- or poly-amino acid claim 1 , peptide claim 1 , saccharide claim 1 , nucleotide claim 1 , organic moiety having approximately 1 to 250 carbon atoms claim 1 , or a combination thereof.6. The complex of wherein the bifunctional linker comprises tetraethylene glycol (TEG) or polyethylene glycol.7. The complex of wherein the reactive group comprises an activated ester claim 1 , phosphoramidite claim 1 , isocyanate claim 1 , isothiocyanate claim 1 , aldehyde claim 1 , acid chloride claim 1 , sulfonyl chloride claim 1 , maleimide claim 1 , alkyl ...

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Номер записи: 51
12-01-2017 дата публикации

PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY

Номер: US20170007693A1
Автор: MUTHUMANI Karupplah, Sardesai Niranjan, Weiner David
Принадлежит:

Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof. 1. A composition for enhancing an immune response against an antigen in a subject in need thereof , comprising:a) PD1 antibody or PDL1 antibody, or combination thereof, andb) a synthetic antigen capable of generating an immune response in the subject, or an immunogenic fragment or variant thereof.2. The composition of wherein the synthetic antigen is an isolated DNA that encodes for the antigen.3Plasmodium falciparumC. difficle.. The composition of wherein the synthetic antigen is selected from the group consisting of: hTERT claim 2 , prostate claim 2 , WT1 claim 2 , tyrosinase claim 2 , NYES01 claim 2 , PRAME claim 2 , MAGE claim 2 , CMV claim 2 , herpes claim 2 , HIV claim 2 , HPV claim 2 , HCV claim 2 , HBV claim 2 , influenza claim 2 , RSV claim 2 , claim 2 , and4. The composition of claim 3 , wherein the HPV antigen is E6 and E7 domains of subtypes selected from the group consisting of: HPV6 claim 3 , HPV11 claim 3 , HPV16 claim 3 , HPV18 claim 3 , HPV31 claim 3 , HPV33 claim 3 , HPV52 claim 3 , and HPV58 claim 3 , and a combination thereof.5. The composition of claim 3 , wherein the HIV antigen is selected from the group consisting of: Env A claim 3 , Env B claim 3 , Env C claim 3 , Env D claim 3 , B Nef-Rev claim 3 , and Gag claim 3 , and a combination thereof.6. The composition of claim 3 , wherein the influenza antigen is selected from the group consisting of: H1 HA claim 3 , H2 HA claim 3 , H3 HA claim 3 , H5 HA claim 3 , BHA antigen claim 3 , and any combination thereof.7Plasmodium falciparum. The composition of claim 3 , wherein the antigen includes a circumsporozoite (CS) antigen.8C. difficle. The composition of claim 3 , wherein the antigen is selected from the group consisting of: Toxin A claim 3 , and ...

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Номер записи: 52
12-01-2017 дата публикации

MICRONEEDLE UNIT AND INJECTION DEVICE

Номер: US20170007812A1
Автор: OGAI Noriyuki, ONOZUKA Kenpei
Принадлежит:

The purpose of the present invention is to provide a micro-needle unit and an injection device capable of being readily connected to a liquid supply source and capable of performing an effective injection via a simple configuration. The micro-needle unit is provided with a plurality of micro-needles disposed on the puncturing side and provided with a flow channel, and drug solution supply needles disposed on the side opposite from the puncturing side in a number less than that of the micro-needles and provided with a flow channel in communication with the aforementioned flow channel, the micro-needle unit thereby being capable of being readily connected to a liquid supply source and capable of performing an effective injection via a simple configuration. 1. A microneedle unit comprising:a plurality of microneedles disposed on a puncturing side and provided with flow channels; andmedicinal solution supply needles disposed on a counter-puncturing side in a number less than the number of the microneedles, provided with flow channels communicating to the flow channels of the microneedles.2. The microneedle unit as claimed in claim 1 , wherein claim 1 ,the flow channels of the microneedles are consolidated into the flow channels of the medicinal solution supply needles.3. The microneedle unit as claimed in claim 1 , wherein claim 1 ,the medicinal solution supply needles are provided in a plural number, and the flow channels of the plurality of medicinal solution supply needles confluent into a communication path, to communicate with the flow channels of the microneedles via the communication path.4. The microneedle unit as claimed in claim 1 , wherein claim 1 ,the size of the flow channels becomes smaller gradually from the medicinal solution supply needle toward the microneedle.5. The microneedle unit as claimed claim 1 , wherein claim 1 ,the microneedles and/or the medicinal solution supply needles are composed of two divisional elements bonded with each other.6. The ...

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Номер записи: 53
12-01-2017 дата публикации

MULTI-SITE ELECTRODE ARRAYS AND METHODS OF MAKING THE SAME

Номер: US20170007813A1
Автор: Bhandari Rajmohan, Negi Sandeep
Принадлежит:

A multi-site electrode array () can include a microneedle array and a set of electrically active sites (). The microneedle array includes a plurality of microneedles () supported on a base substrate (). The set of electrically active sites () can be arranged at and/or near the tip of each microneedle (), and in many cases along a shaft of the microneedles. Further, at least a portion of the active sites () can be independently electrically addressable such that a remaining portion of the active sites () are optionally electrically shunted together. In some cases all of the active sites () are independently electrically addressable 1. A multi-site electrode array comprising:a) a microneedle array including a plurality of microneedles supported on a base substrate; andb) a set of electrically active sites arranged on each microneedle, each active site in the set being independently electrically addressable.2. The array of claim 1 , wherein the array is a two dimensional array such that the plurality of microneedles are distributed in two dimensions across the base substrate.3. The array of claim 1 , wherein the plurality of microneedles are substantially parallel to one another.4. The array of claim 1 , wherein the microneedles and the base substrate are formed of a contiguous and common material.5. The array of claim 1 , wherein a spatial configuration across the plurality of microneedles for the sets of electrically active sites forms a three-dimensional volume of electrically active sites.6. The array of claim 1 , wherein at least a portion of the electrically interactive sites are electrically connected to a base contact via independent lead lines formed of an electrically conductive material deposited along a shaft portion of the microneedles claim 1 , wherein at least a portion of the base contacts are electrically independent of one another.7. The array of claim 1 , further comprising transistor gates and pads oriented on an underside of the base substrate and ...

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Номер записи: 54
11-01-2018 дата публикации

METHOD FOR PREVENTING, TREATING, AND CURING CANCER

Номер: US20180008534A1
Автор: LOMERSON ROBERT B.
Принадлежит:

The present application includes a method for introducing a hormone directly into an affected area within a tumor. The method includes penetrating the affected area of the tumor with a biopsy needle in order to obtain a biopsy specimen. The specimen is withdrawn along with the biopsy needle. A hormone implant is inserted into the void space left behind as the specimen was removed. The method may also include directly inserting the implant and a treating substance into the tumor without the removal of the biopsy specimen. The implant may have various shapes in order to maximize surface contact. The implant is also configured to have a time release function to regulate dosage delivery. 1. A method for introducing a hormone directly into an affected area within a tumor , comprising:penetrating the affected area of the tumor with a biopsy needle in order to obtain a biopsy specimen;withdrawing the biopsy needle and a biopsy sample; andinserting a biodegradable hormone implant into a void space created by the removal of the biopsy sample.2. The method of claim 1 , further comprising:activating the implant by the use of at least one of an ultrasonic energy, a magnetic vibration, a temperature variation, and a stimulation.3. The method of claim 1 , wherein the implant is shaped as a curvilinear blade to promote uniform distribution of the hormone implant into the tumor.4. The method of claim 1 , wherein the implant is shaped having extensible fibers wherein each fiber extends out into the tumor so as to maximize surface contact in the tumor.5. The method of claim 1 , wherein the implant is shaped in a threaded form claim 1 , such that the implant threads encircle a central axis in a continuous radial pattern.6. The method of claim 1 , wherein the implant is a biodegradable estrogen rich hormone.7. The method of claim 1 , wherein the hormone implant includes a balance of estrogen and testosterone.8. The method of claim 1 , wherein the hormone implant includes at least one ...

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Номер записи: 55
11-01-2018 дата публикации

VAGINAL LAXITY THERAPY UTILIZING CELL-BASED BULKING COMPOSITIONS

Номер: US20180008647A1
Автор: Yonce David J.
Принадлежит:

The invention provides methods for the treatment of vaginal laxity which include delivering a cell-containing composition to the vagina. The composition can include fat tissue to provide a bulking effect to reduce the size of the vaginal opening. The cells can provide healing and revascularization of the vaginal treatment area to sustain the bulking provided by the fat. The invention also provides systems and compositions useful for performing the method, and can include instruments and devices for removal of autologous adipose tissue from a patient (e.g., by liposuction), equipment for the enrichment of cells from adipose tissue, mechanical processing of adipose tissue, and the mixing of cells and processed adipose tissue. Devices for the delivery of the cell compositions to the vagina can also be included in the system. 1. A method for treating vaginal laxity , comprising steps of:providing a composition comprising autologous tissue, cells, or both, from a patient; andintroducing the composition into the vaginal cavity to treat the vaginal laxity.2. The method of which reduces the size of the vaginal cavity.3. The method of wherein the step of providing comprises obtaining a tissue sample from the patient and processing the sample to isolate or enrich cells for the composition.4. The method of wherein the autologous tissue claim 1 , cells claim 1 , or both claim 1 , is from adipose tissue.5. The method of wherein step of providing comprises removing the adipose tissue from a patient by liposuction claim 4 , and using tissue processing equipment to isolate or enrich adipose tissue-derived cells from adipose tissue.6. The method of claim 1 , where claim 1 , in the step of providing claim 1 , the composition comprises claim 1 , in addition to autologous cells claim 1 , adipose tissue processed by mechanical action.7. The method of wherein the adipose tissue processed by mechanical action acts as a bulking agent claim 6 , and the autologous cells promote healing and ...

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Номер записи: 56
27-01-2022 дата публикации

Fucoidan hair growth agent

Номер: US20220023184A1
Автор: Akira Yamamoto, Fumio Kamiyama, Hidemasa Katsumi, Hirofumi Yamashita, Ying-Shu Quan
Принадлежит: CosMED Pharmaceutical Co Ltd

To develop a novel administration method of a fucoidan-containing hair-growing agent and to provide a means for exerting excellent effects of a fucoidan. A hair-growing agent of the present invention is characterized in that it is composed of a combination of a fucoidan-containing microneedle and a fucoidan-containing liniment. A base of the fucoidan-containing microneedle is preferably a biosoluble polymer. A hair-growing method of the present invention is characterized in that the fucoidan-containing microneedle and the fucoidan-containing liniment are concomitantly used.

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Номер записи: 57
11-01-2018 дата публикации

MICRONEEDLE ARRAY AND METHOD OF USE

Номер: US20180008807A1
Автор: BERG DANIEL H., FRITS MICHAEL J., GYSBERS JEROME E., MOECKLY CRAIG S., Simmers Ryan Patrick
Принадлежит: 3M INNOVATIVE PROPERTIES COMPANY

An article () comprising at least one microneedle () is provided. The article comprises a first side () and a second side () opposite the first side. The first side comprises a central cavity portion () and a platform portion (), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (); a base segment () having a base () and a first shape; a tip segment () having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane () that delineates the base segment and the tip segment; and a central axis (). Methods of using the article are also provided. 1. An article , comprising:a first side comprising a central cavity portion and a platform portion that projects from the first side and that is not coplanar with the central cavity portion;a second side opposite the first side; andat least three hollow microneedles extending from the platform portion in a first direction;wherein the platform portion substantially surrounds the central cavity portion;wherein the platform portion comprises an inner perimeter proximate the central cavity portion and an outer perimeter distal the central cavity portion; an outer surface;', 'a base segment having a base and a first shape that is defined by a first section of the outer surface;', 'a tip segment having a tip and a second shape that is defined by a second section of the outer surface, wherein the second shape is distinct from the first shape;', 'a transition plane that delineates the base segment and the tip segment; and', 'a central axis;, 'wherein the at least three hollow microneedles each comprise a body that compriseswherein a first angle, defined by the central axis of each of the at least three hollow microneedles and a shortest line extending from the outer ...

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Номер записи: 58
11-01-2018 дата публикации

Devices for Transdermal Drug Delivery

Номер: US20180008808A1
Автор: CHOWDHURY Dewan Fazlul Hoque
Принадлежит: NDM TECHNOLOGIES LIMITED

A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place. 1. A transdermal drug delivery device comprising:a number of needles for piercing the skin of a patient to form a number of pores in the skin;a number of carriers, each carrier being an elongate element having a tip for loading with a drug to be delivered; andmeans operable while the needles remain in the skin for applying each carrier to a pore to deliver the drug to the pore.2. A device according to claim 1 , wherein each of the carriers is located such that it can be introduced into the pore alongside the corresponding needle.3. A device according to claim 1 , further comprising a drug loaded on the tips of the carriers.4. A device according to claim 3 , wherein the drug is adhered to the tips of the carriers.5. A device according to claim 3 , further comprising a channel associated with each carrier claim 3 , along which the carrier can slide claim 3 , wherein the drug is contained within the channel by the tip of the carrier.6. A device according to claim 1 , wherein each of the carriers is movable relative to a corresponding one of the needles.7. A device according to claim 6 , further comprising a channel associated with each carrier claim 6 , along which the carrier can slide.8. A device according to claim 7 , wherein the channel is located in the corresponding needle.9. A device according to claim 7 , comprising a first insert part that defines a first portion of the channel and a second insert part that defines a second portion of the channel claim 7 , the ...

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Номер записи: 59
11-01-2018 дата публикации

DEVICES, SYSTEMS, AND METHODS FOR INDUCING DERMAL BLOOD VESSEL LEAKAGE

Номер: US20180008838A1
Автор: Wu Mei X.
Принадлежит:

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject. 1. A device comprising:at least one penetration member having a body defined by oppositely disposed proximal and distal ends, the body having a length such that at least a portion of the distal end extends into a dermis of the skin of a subject when the device is contacted with the subject's skin; anda laser source coupled to the at least one penetration member so that, upon activation, the laser source delivers a laser beam into the dermis for a time sufficient to induce leakage or rupture of at least one blood vessel comprising the dermis.2. The device of claim 1 , wherein the penetration member is a needle claim 1 , a microneedle claim 1 , or a microprojection comprising a microneedle array or a microprojection array.3. The device of claim 1 , wherein the penetration member is hollow and the laser source is coupled to an optical fiber that is at least partly disposed within the hollow penetration member.4. The device of claim 1 , wherein the penetration member is made of a solid claim 1 , transparent material such that the laser beam penetrates into the dermis via the penetration member.5. The device of claim 1 , wherein at least part of the device is configured as a handheld claim 1 , point-of-care device.6. The device of claim 1 , wherein at least a portion of the distal end is coated with one or more detection reagents for detecting one or more target analytes in the fluid leaked ...

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Номер записи: 60
27-01-2022 дата публикации

Microstructure-based Drug Injection Device and Method for Manufacturing the Same

Номер: US20220023604A1
Автор: JEON So Hee, JEONG Jun Ho, KIM Ki Don, LEE Joo Buom, YOON Seok Min
Принадлежит:

A method for manufacturing a microstructure-based drug injection device according to an embodiment of the present invention includes: a forming mold preparation step for preparing a forming mold formed in a shape corresponding to a microstructure to be manufactured; a biodegradable material-mixed solution application step for applying a biodegradable material-mixed solution to the forming mold; a primary drying step for drying the biodegradable material-mixed solution applied to the forming mold and forming a needle film in which the microstructure is formed; a drug filling step for filling a drug into a filling space formed by the microstructure; and a secondary drying step for drying the needle film, wherein, in the filling space that has undergone the secondary drying step, an inner space portion is formed in a region other than in the region in which the drug is accommodated. 1. A method for manufacturing a microstructure-based drug injection device , comprising:preparing a forming mold having a shape that corresponds to a microstructure to be manufactured;applying a biodegradable material-mixed solution to the forming mold;primary drying to form a needle film where the microstructure is formed by drying the biodegradable material-mixed solution applied to the forming mold;drug filling for filling a drug in a filling space formed by the microstructure; andsecondary drying for drying the needle film,wherein an inner space is formed in an area other than an area where the drug is accommodated in the filling space that has undergone the secondary drying.2. The method for manufacturing the microstructure-based drug injection device of claim 1 , wherein:the drug filled in the filling space is in a fluid state in drug filling; andat least a part of the drug filled in the filling space is permeated into the microstructure in the drug filling.3. The method for manufacturing the microstructure-based drug injection device of claim 2 , whereina droplet diameter of the drug ...

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Номер записи: 61
27-01-2022 дата публикации

Microneedle Immunotherapeutic Multi-Component System and a Method for Vaccination

Номер: US20220023605A1
Автор: PAVLOV Andrei Jurievich, ZVEZDIN Vasilii Nikolaevich
Принадлежит:

A dissoluble microneedle drug delivery system includes a fixation component having an opening window area, and at least two replaceable and/or dissoluble inner matrices fitting into the window area one after another. The fixation component comprises an array of microneedles attached on its base, at least part of the microneedles being configured to fix the delivery system onto skin. The first inner matrix comprises a multitude of microneedles attached on its base, at least part of the microneedles configured to prepare the skin to vaccination by the subsequent second inner matrix. The second inner matrix is a vaccine/immunization matrix configured to replace the first inner matrix and comprising an array of microneedles attached on its base, at least part of the microneedles configured to deliver a vaccination. The system may include a microchannel network within at least one inner matrices for delivery of components regulating dissolution of the microneedles. 1. A dissoluble microneedle drug delivery system , comprising:an outer microneedle matrix, and the outer microneedle matrix optionally mounted on a fixation frame and having an opening window in its center, and having a microneedle array affixed on its base, the microneedle array comprising microneedles of different lengths such that the longest microneedles are located on outer edges of the outer microneedle matrix, and the shorter microneedles are located around the opening window area, the longest microneedles configured to be used for fixation of the matrix onto the skin and additionally for delivery of an adjuvant, and the shorter microneedles being configured to be used for adjuvant preparation of the skin;', 'the first inner matrix fitting into the opening window area and having a microneedle array affixed onto its base, the microneedle array comprising a multitude of dissoluble microneedles containing skin preparation components and being configured to prepare skin underneath the matrix for vaccination ...

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Номер записи: 62
27-01-2022 дата публикации

MICRONEEDLE AND CHIP

Номер: US20220023606A1
Автор: Rangsten Pelle, Renlund Markus
Принадлежит:

A microneedle and a chip are disclosed for extraction fluids. The microneedle is provided on a substrate and comprises an elongated body extending from a distal end with a bevel to a proximal end on the substrate along a longitudinal axis. The elongated body comprises a capillary bore extending in a longitudinal direction thereof and defines a fluid path. The proximal end is integrally connected with the substrate and the capillary bore is in fluid communication with a fluid channel of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross-sectional area of the capillary bore in the proximal end. 1. A microneedle provided on a substrate , comprising: the elongated body comprises a capillary bore extending in a longitudinal direction thereof and defines a fluid path;', 'the proximal end is connected to the substrate and the capillary bore is in fluid communication with a fluid channel of the substrate;', 'wherein the cross-sectional area of the capillary bore comprises a triangular cross-section in a perpendicular direction relative the longitudinal direction of the microneedle., 'an elongated body extending from a distal end thereof with a bevel to a proximal end on the substrate along a longitudinal axis, wherein2. A microneedle according to claim 1 , wherein the triangular cross-section of the capillary bore further comprises at least one rounded corner.3. A microneedle according to claim 1 , wherein the triangular cross-section of the capillary bore comprises a convex base connected to straight sections via two rounded corners.4. A microneedle according to claim 1 , wherein the capillary bore comprises a hydrophilic surface.5. A microneedle according to claim 1 , wherein the fluid channel is configured to provide an under-pressure claim 1 , relative the atmospheric pressure claim 1 , to the capillary bore claim 1 , whereby fluid flow through the capillary bore is promoted.6. A microneedle according to claim 1 , ...

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Номер записи: 63
14-01-2021 дата публикации

3D Printed Microneedles for Microencapsulated Mammalian Cell Extrusion

Номер: US20210008359A1
Автор: Farias Chantell, Hemingway Cecilia, Lyman Roman, Mobed-Miremadi Maryam
Принадлежит:

A 3D printed biocompatible drug delivery device is provided having a fluid delivery channel distinguishing three segments and a receiving chamber with an array of microneedles. The three segments of the delivery channel are stagnation zones before a drug is extruded and whereby an inverted funnel provides an increasing extrusion surface servicing the drug to the array of microneedles. The design of the device with its flow-related components circumvents the challenge of colloidal stability associated with multi-phase formulations leading to nozzle blockage. Qualitative screening cytotoxicity tests pre and post-extrusion through the drug delivery device using mammalian cells rule out cytotoxicity and outline equivalent viability to control treatments. The biocompatibility results suggest that the fluid delivery design, the photoresin selected as well as the fabrication and sterilization may be extended over a range of regenerative medicine and drug delivery applications. 1. A biocompatible drug delivery device , comprising: wherein the first segment is a funnel with a diameter suitable to receive a syringe,', 'wherein the second segment is a cylinder connected to the smallest diameter of the funnel, and wherein the diameter of the cylinder matches the smallest diameter of the funnel,', 'wherein the third segment is an inverted funnel connected to the other side of the cylinder at the smallest diameter of the inverted funnel,', 'wherein the diameter of the smallest diameter of the inverted funnel matches the diameter of the cylinder, and', 'wherein the inverted funnel diverges with an angle ranging from 10 to 45 degrees; and, '(a) a fluid delivery channel distinguishing three segments,'} wherein each microneedle protrudes with an orifice from the bottom surface of the receiving chamber,', 'wherein a section of the top surface of the receiving chamber fluidically connects to the bottom surface of the fluid delivery channel such that the array of microneedles matches up ...

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Номер записи: 64
14-01-2021 дата публикации

Adhesion Member and Microneedle Patch

Номер: US20210008360A1
Автор: Hidetoshi Hamamoto, Katsunori Kobayashi
Принадлежит: MedRx Co Ltd

The patch or the like of the present invention is useful for pharmaceuticals and the like because the puncturability of microneedle is improved, and a microneedle array can be firmly fixed to the skin, and drugs can be quantitatively administered without waste.

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Номер записи: 65
09-01-2020 дата публикации

SUSTAINED INTRATONSILLAR DRUG DELIVERY WITH NEEDLE ARRAY

Номер: US20200008825A1
Автор: CHO DO-YEON, Lim Dong-Jin, WOODWORTH BRADFORD A.
Принадлежит:

Various embodiments for sustained drug delivery using a needle array are disclosed. A medical instrument and a method associated therewith are described for delivering drugs into tonsillar and other tissue as a way of treating tonsillar hypertrophy or inflammation, as an alternative to tonsillectomy and adenoidectomy (T&A) procedures. In some embodiments, a tonsil-accessible medical instrument is described as including a needle head having needles, or microneedles, disposed therein and capable of introducing a compound, such as a steroid, into tissue. The medical instruments enables for the delivery of various compounds, such as pharmaceuticals, for controlled and sustained release. 1. A medical instrument , comprising:a handle portion;a central member coupled to a distal end of the handle portion; anda needle head coupled to a distal end of the central member, the needle head comprising a needle array disposed in a cavity of the needle head, wherein the needle array comprises a plurality of needles configured with a compound that, when the plurality of needles are introduced into tissue, causes a delivery of the compound into the tissue.2. The medical instrument of claim 1 , wherein the plurality of needles are a plurality of microneedles claim 1 , each of the plurality of microneedles having a needle size of about 250 micrometers to 2 claim 1 ,500 micrometers.3. The medical instrument of claim 2 , wherein the needle head comprises an ovular cylinder.4. The medical instrument of claim 3 , wherein the needle head comprises an elliptically concave inner surface claim 3 , wherein each of the plurality of microneedles are disposed along the elliptically concave inner surface.5. The medical instrument of claim 1 , wherein the central member is C-shaped claim 1 , the central member comprising a first bend forming a first angle between a first portion of the central member and a second portion of the central member claim 1 , and a second bend forming a second angle ...

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Номер записи: 66
09-01-2020 дата публикации

THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE

Номер: US20200009045A1
Автор: Imran Mir
Принадлежит:

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract. 1. (canceled)2. A method for delivering PTH or PTH analogue to a patient in need thereof , the method comprising:providing a swallowable enclosure having an interior, a delivery means, and a PTH or PTH analogue preparation coupled to the delivery means, the PTH or PTH analogue preparation comprising a therapeutically effective dose of PTH or PTH analogue, the delivery means having a first configuration and a second configuration, the preparation being contained within the interior in the first configuration and advanced out of the interior and into a gastro-intestinal (GI) lumen wall in the second configuration so as to deliver the PTH or PTH analogue preparation into the GI lumen wall, the enclosure protecting the PTH or PTH analogue preparation from degradation by GI fluids, the PTH or PTH analogue preparation supplied in the enclosure in a form which can be delivered from the enclosure into the GI lumen wall by the application of force on the preparation; andtriggering the ...

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Номер записи: 67
10-01-2019 дата публикации

SYSTEMS AND METHODS FOR REDUCING OR PREVENTING BACKFLOW IN A DELIVERY SYSTEM

Номер: US20190009055A1
Автор: Anand PJ, Sama Blake, Singh Deep Arjun
Принадлежит: ALCYONE LIFESCIENCES, INC.

Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid. 126-. (canceled)27. A micro-molding device , comprising:a mold cavity sized and configured to receive a catheter body and a catheter micro-tip therein such that at least one fluid channel of the micro-tip is at least partially disposed within a corresponding fluid line of the catheter body; andone or more mold channels though which a mold fluid can be injected to fill the mold cavity and secure the micro-tip to the catheter body such that the at least one fluid channel of the micro-tip is in fluid communication with the at least one fluid line of the catheter body.28. The device of claim 27 , wherein the device is transparent to allow UV light to pass therethrough to cure mold fluid disposed within the mold cavity.29. The device of claim 27 , wherein the mold cavity is sized and configured to form a bullet nose portion over the micro-tip and over at least a portion of an outer sheath received in the mold cavity.3038-. (canceled) This application is a continuation of U.S. application Ser. No. 14/132,762 filed on Dec. 18, 2013, which claims priority to U.S. Provisional Application No. 61/738,850 filed on Dec. 18, 2012 and U.S. Provisional Application No. 61/835,912 filed on Jun. 17, 2013, which are each incorporated herein by reference in their ...

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Номер записи: 68
10-01-2019 дата публикации

Microneedle sheet

Номер: US20190009070A1
Автор: Naoki Yamamoto, Ryusuke FUDOJI
Принадлежит: Hisamitsu Pharmaceutical Co Inc

The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.

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Номер записи: 69
09-01-2020 дата публикации

MICRO NEEDLE

Номер: US20200009361A1
Автор: KIM Jae Heon, KIM Seong Ok, KIM So Min, YOUN Yong Sook
Принадлежит: GL.company

A micro needle includes: a first base; a second base formed integrally with the top surface of the first base; a needle support formed integrally with the top surface of the second base and leading to a tapered groove penetrating the bottom surface of the first base; and a needle body formed integrally with the center of the top surface of the needle support and having a needle hole leading to the tapered groove. The micro needle allows for low-cost mass production because of the simple structure, and involves applying various drugs by injecting drugs after puncturing the skin. 1. A micro needle comprising:a first base;a second base formed integrally with the top surface of the first base;a needle support formed integrally with the top surface of the second base and leading to a tapered groove penetrating the bottom surface of the first base; anda needle body formed integrally with the center of the top surface of the needle support and having a needle hole leading to the tapered groove.2. The micro needle of claim 1 , wherein the first and second bases are disc-shaped claim 1 , and the needle support is cone-shaped.3. The micro needle of claim 1 , wherein the needle support is 1.3 to 1.7 mm long claim 1 , the maximum inner diameter of the tapered groove is 1.5 to 2.5 times the outer diameter of the needle support claim 1 , and the top inner diameter of the tapered groove is 1.5 to 3 times the outer diameter of the needle body.4. The micro needle of claim 1 , wherein the needle body is 0.1 to 1.0 mm long claim 1 , with an outer diameter of 40 to 300 μm claim 1 , and the needle hole has an inner diameter of 30 to 250 μm.5. The micro needle of claim 1 , wherein the needle hole is punched from the bottom of the needle support using a micro drill. This U.S. non-provisional patent application claims priority under 35 U.S.C. § 119 of Korean Patent Application No. 10-2018-0077388, filed on Jul. 4, 2018, the entire contents of which are hereby incorporated by reference.The ...

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Номер записи: 70
09-01-2020 дата публикации

FLUID DELIVERY APPARATUS AND METHOD OF ASSEMBLY

Номер: US20200009362A1
Автор: Baker Andrew T., Gadsby Elizabeth D., Ganapathy Pratap, Hagan Luke, Peck Aaron, Ross Russell F., Yamada Alyson
Принадлежит:

A fluid delivery apparatus includes a collet assembly having an upper and lower wall attached at a central portion of the collet. The central portion defines an inner step, and the lower wall includes circumferentially-spaced flexible tabs. The fluid delivery apparatus also includes a fluid distribution assembly coupled to the collet assembly. The fluid distribution assembly is positionable relative to the collet between a pre-use configuration and a pre-activated configuration. The fluid distribution assembly has a plenum that includes a sleeve component having an exterior ledge extending thereabout. A lower wall portion of the sleeve component includes protrusions corresponding to the flexible tabs of the collet. In the pre-use configuration the exterior ledge of the sleeve component is engaged with the inner step of the collet assembly, and each flexible tab engages a respective protrusion to provide a snap-fit between the fluid distribution assembly and the collet assembly. 1. A fluid delivery apparatus having a central axis , the fluid delivery apparatus comprising:a collet assembly comprising an upper wall and a lower wall coupled together at a central portion of the collet assembly, the central portion defining an inner step, the lower wall comprising a plurality of flexible tabs spaced circumferentially equidistant about the central axis; anda fluid distribution assembly coupled to the collet assembly, the fluid distribution assembly being positionable relative to the collet assembly between a pre-use configuration and a pre-activated configuration, the fluid distribution assembly comprising a plenum assembly and a cartridge assembly containing a fluid, the plenum assembly comprising a sleeve component having a wall comprising an upper wall portion and a lower wall portion coupled to the upper wall portion and defining an exterior ledge extending about the sleeve component, the lower wall portion comprising a plurality of protrusions spaced circumferentially ...

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Номер записи: 71
09-01-2020 дата публикации

Microneedle template and microneedle prepared using the same

Номер: US20200009363A1
Автор: Bo Young SHIN, Jeong Gun Lee, Shin Hee Cho
Принадлежит: S-Skin Co Ltd

Provided are a microneedle template including: a substrate on which at least one microneedle shapes are formed; and a diamond layer formed on the surface of the at least one microneedle shapes, a method for preparing the microneedle template, a microneedle prepared using the microneedle template, and a method for preparing the microneedle.

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Номер записи: 72
09-01-2020 дата публикации

MICRONEEDLES AND COMPOSITIONS FOR SKIN AUGMENTATION

Номер: US20200009364A1
Автор: AMIR Avraham
Принадлежит:

The present invention provides microneedles for administration of biocompatible materials effective in augmentation of skin or other skin treatments, and applicators comprising such microneedles. In particular, the microneedles and applicators of the present invention are aimed at filling the undesired lines, wrinkles, depressed scars and folds of a subject's facial and neck skin and restoring youthful fullness to the skin. 2. The microneedle of claim 1 , wherein the shape of the cross-section area of the rod section claim 1 , the tip section and the base section is selected from: rectangular claim 1 , triangular claim 1 , circular claim 1 , oval claim 1 , polygonal claim 1 , and any combination thereof.3. The microneedle of claim 1 , wherein the at least one cavity comprises the biocompatible medical composition claim 1 , and wherein the biocompatible medical composition or at least part of the biocompatible medical composition is solid and/or semi-solid at room temperature and is configured to be released from the cavity/ies to the dermis and/or hypodermis upon contact with liquid in the dermis layer and/or hypodermis layer.4. The microneedle of claim 3 , wherein at least one of the following holds true:the biocompatible medical composition is configured to at least partially separate from the cavity and the microneedle, when in dermis and/or hypodermis environment;biocompatible medical composition comprises at least one of: skin augmentation material, botulinum composition, medical pigment composition, steroids and any combination thereof; at least one of: skin augmenting material, botulinum material, medical pigment material, steroids, and any combination thereof;', 'at least one dispersant material, configured to disperse the at least one of: skin augmenting material, botulinum material, medical pigment material, steroids upon contact with the dermis layer and/or the hypodermis layer and any combination thereof; and', 'at least one dispersant material, ...

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Номер записи: 73
09-01-2020 дата публикации

SYSTEM AND METHOD FOR OPTOGENETIC THERAPY

Номер: US20200009397A1
Автор: Andersen Dan, Arrow Alexander K., Deisseroth Karl, Lundmark David C., Moll Fred
Принадлежит: Circuit Therapeutics, Inc.

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. 1a. implanting an optical applicator and coupling it to at least one tissue structure such that it can deliver photons to at least one branch of the renal nerve plexus that has been genetically modified to have light sensitive protein;b. implanting an implantable light source and intercoupled implantable power supply and coupling each to at least one tissue structure, the implantable light source being configured to deliver photons as an input to the optical applicator when the implantable light source is drawing power from the implantable power supply;c. deploying an implantable sensor within the body of the patient, the sensor configured to provide an output signal that is correlated with the blood pressure of the patient; andd. implanting an implantable controller and coupling it to at least one tissue structure, the implantable controller configured to cause the implantable light source to direct enough illumination to the light sensitive protein through the implantable light source and implantable light applicator to at least partially inhibit action potential transmission within the at least one branch of the renal nerve plexus based at least in part upon the output signal received from the implantable sensor.. A method for preventing ...

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Номер записи: 74
09-01-2020 дата публикации

Method and Device for Manufacturing Dissolving Microneedle

Номер: US20200009767A1
Автор: LI Chengguo
Принадлежит:

A method and a device for manufacturing dissolving microneedle, wherein the method comprises manufacturing a mold with a plurality of microporous cavities, and manufacturing a polymer solution to be sprayed into the microporous cavity by a high pressure spraying device to enable the sprayed solution to fill in each microporous cavity. After the dryness of the solution, a microneedle is extracted from the mold. The process for manufacturing the microneedle is without vacuum pumping or any load of centrifugal force, and the process is simple and the excellent rate is high. 1. A method for manufacturing dissolving microneedle , comprising manufacturing a microneedle mold , said microneedle mold has a plurality of microporous cavities , wherein a polymer solution is sprayed into the microporous cavity by a high pressure spraying device to enable the polymer solution to fill into each of the microporous cavities; and the solidified microneedle are extracted from the microneedle mold after the dryness of polymer solution.2. The method for manufacturing dissolving microneedle according to claim 1 , wherein said polymer solution sprayed into the microporous cavity by the high pressure spray device comprises the atomized polymer solution sprayed into the microporous cavity by a high pressure atomizing device.3. The method for manufacturing dissolving microneedle according to claim 2 , wherein the particle size of said atomized polymer solution sprayed by the high pressure atomizing device ranges from 0.1 to 100 micrometers.4. The method for manufacturing dissolving microneedle according to claim 1 , wherein said polymer solution sprayed into the microporous cavity by the high pressure spray device comprises the droplets of the polymer solution sprayed to the microporous cavity by the high pressure spotting device.5. The method for manufacturing dissolving microneedle according to claim 4 , wherein the particle size of said droplets of the polymer solution sprayed by the high ...

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Номер записи: 75
03-02-2022 дата публикации

METHOD AND SYSTEM FOR HEALTH IMPROVEMENT USING TOILET SEAT SENSORS

Номер: US20220031255A1
Автор: BORUFF Scott Michael, GREENWOOD Kenneth M., VOLLRATH Jurgen
Принадлежит:

In a telemedicine system, physiological sensors are provided in a toilet seat for monitoring physiological parameters of the subject, corroborate sensor data against other sensor data and notify personnel in the event of a problem or Concern. 1. A system for remote medicine , comprisinga smart toilet seat that includes at least one toilet seat sensor,at least one non-toilet seat sensor,a processor connected to the sensors,memory enabled with machine readable code defining an algorithm for identifying a trigger event based on anomalies in the data from at least one toilet seat sensor, and defining an algorithm for corroborating the trigger event from the at least one toilet seat sensor with data from at least one other toilet seat sensor or at least one non-toilet seat sensor, to define a flagging event, andnotifying one or more people about the flagging event and details about said event.2. The system of claim 1 , wherein an anomaly includes one or more of a physiological characteristic or condition of interest claim 1 , and a change in a physiological parameter.3. The system of claim 1 , wherein the at least one toilet seat sensor includes one or more of claim 1 , an electrocardiogram (ECG) for measuring the electrical activity of the heart claim 1 , a pulse oximeter or photoplethysmogram (PPG) for measuring blood oxygenation and localized pulse timing claim 1 , a ballistocardiogram (BCG) for measuring the mechanical forces associated with the cardiac cycle claim 1 , and a body weight sensor.4. The system of claim 1 , wherein the at least one non-toilet seat sensor includes one or more of an image capture device claim 1 , a microphone claim 1 , a genetic sensor claim 1 , and a drug compliance sensor.5. The system of claim 4 , wherein the image capture device includes one or more cameras mounted at different locations and operating at different ranges of the frequency spectrum.6. The system of claim 5 , wherein the image capture device includes a camera mounted in ...

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Номер записи: 76
03-02-2022 дата публикации

Device and Method for Producing Microstructures

Номер: US20220032026A1
Автор: Dommasch Sebastian, Erlhofer Stefan, Fehr Thorsten, Kulik Michael, SCHERR Sebastian
Принадлежит:

A device for manufacturing microstructures including a permeable template, wherein the template comprises at least one recess for manufacturing the microstructures. In addition, the device comprises a vacuum-generating device connected to the template such that a vacuum is applied to at least one side of the template. Further, a method for filling a permeable template, wherein the template comprises at least one recess for manufacturing microstructures. The method comprises feeding the at least one substance to be filled in to the template as well as generating a vacuum on at least one side of the template 1. A device for manufacturing microstructures , in particular microneedles , comprising:at least one permeable gas-transmissible template,wherein the at least one template comprises at least one conical recess for manufacturing the microstructures,wherein at least one device is connected to the at least one template for generating a vacuum such that a vacuum is applied to at least one side of the at least one template, in particular at least opposite the at least one recess of the at least one template.2. The device according to claim 1 , further comprising a vacuum chamber connected to the at least one template claim 1 , wherein the vacuum chamber is configured such that the vacuum chamber at least temporarily maintains by itself an externally generated vacuum.3. The device according to claim 2 , wherein the vacuum chamber comprises at least one vacuum chamber opening for connecting to a pump for generating a vacuum in the vacuum chamber.4. The device according to claim 1 , further comprising a coupling device for selectively coupling a vacuum-generating device to the template claim 1 , preferably to the vacuum chamber claim 1 , particularly preferably to the vacuum chamber opening.5. The device according to claim 3 , further comprising at least one self-closing valve for closing the at least one vacuum chamber opening such that an existing pressure ratio inside ...

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Номер записи: 77
03-02-2022 дата публикации

HOLLOW MICRONEEDLE FOR TRANSDERMAL DELIVERY OF ACTIVE MOLECULES AND/OR FOR THE SAMPLING OF BIOLOGICAL FLUIDS AND MANUFACTURING METHOD OF SUCH HOLLOW MICRONEEDLE

Номер: US20220032027A1
Автор: Dardano Principia, DE STEFANO Luca, Nicolais Luigi
Принадлежит: Altergon SA

The present invention relates to a micro-needle (7; 8; 9) for the transdermal administration of active molecules and/or for the sampling of biological fluids. The micro-needle (7; 8; 9) is made of polymeric material through photolithography. A cavity is defined in the micro-needle (7; 8; 9). 178978977789. Method for the optical activation of the release of an active ingredient by means of a micro-needle (; ; ) , said micro-needle (; ; ) being made of a polymeric material added with a photosensitive polymer or with a photosensitive compound , a blind cavity () being defined in said micro-needle (; ; ) and containing said active ingredient , comprising the step of:{'b': 7', '8', '9, 'exposing said micro-needle (; ; ) to a coherent radiation having a predetermined wavelength such to energize said photosensitive polymer or said photosensitive compound, said coherent radiation being preferably in the near infrared field.'}278978977789. Method for the thermal activation of the release of an active ingredient by means of a micro-needle (; ; ) , said micro-needle (; ; ) being made of a polymeric material added with metal particles , preferably particles of a noble metal , even more preferably gold particles , a blind cavity () being defined in said micro-needle (; ; ) and containing said active ingredient , comprising the step of:{'b': 7', '8', '9, 'exposing said micro-needle (; ; ) to a coherent radiation having a predetermined wavelength such to heat by radiation said metal particles, said coherent radiation being preferably in the near infrared field.'}4464060353050. Method according to claim 3 , wherein the predetermined distance (f) between the geometric center (C; C) of said external profile (; ) and the geometric center (C; C) of said inner profile (; ) is comprised between 10 micrometers and 200 micrometers claim 3 , preferably between 30 micrometers and 50 micrometers claim 3 , even more preferably about 40 micrometers.5789. Method for obtaining through ...

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Номер записи: 78
03-02-2022 дата публикации

PILL WITH NEEDLE DELIVERY SYSTEM HAVING OUTWARDLY EXPANDING MECHANICAL ACTUATION

Номер: US20220032028A1
Автор: Bennett Eric, Kam Kimberly, Karicherla Annapurna, MacPhail Kassidy, Sheridan Martin
Принадлежит: Verily Life Sciences LLC

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles. 1. A system comprising: an inner surface defining an interior volume of the capsule; and', 'an outer surface sized to pass through a lumen defined by a lining of a gastrointestinal tract;, 'a capsule comprising a shell havinga carrier sized to fit within the interior volume of the capsule and bearing an array of microneedles; and a foldable biasing member comprising a first end and a second end, the foldable biasing member comprising a flexibly resilient material having a flexibility permitting the first end and the second end to be foldable toward one another for movement from an expanded state toward a collapsed state in which the mechanical actuator fits within the interior volume of the capsule, the flexibly resilient material further having a resiliency that biases the first end and the second end apart from one another for movement from the collapsed state toward the expanded state to move the carrier outwardly upon the mechanical actuator overcoming or escaping from constraint provided by the capsule; and', 'a holder hingedly attached with the first end of the biasing member and comprising a support ...

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Номер записи: 79
03-02-2022 дата публикации

MICRONEEDLE ELECTROPORATION DEVICE

Номер: US20220032049A1
Автор: CHAO Bo-Kai, Hsu Chih-Hao, Tsai Jui-Hung, Wang Ying-Hao
Принадлежит:

A microneedle electroporation device is provided, including a housing, a positioning member, an intermediate plate, a first microneedle assembly, a second microneedle assembly, a socket, a first wire, and a second wire. The positioning member is connected to the housing and the intermediate plate. The intermediate plate includes a plurality of first holes and a plurality of second holes. The first microneedle assembly includes a plurality of first microneedles and a first metal connecting portion connected to the first microneedles. The first microneedles pass through the first holes. The second microneedle assembly includes a plurality of second microneedles and a second metal connecting portion connected to the second microneedles. The second microneedles pass through the second holes. The first microneedle assembly and the second microneedle assembly are electrically independent of each other. The first wire connects the socket to the first metal connecting portion. The second wire connects the socket to the second metal connecting portion. 1. A microneedle electroporation device , configured to be connected to an injecting device , wherein the microneedle electroporation device comprises:a housing, having an accommodating space;a positioning member, connected to the housing; a first surface, facing the accommodating space;', 'a second surface, opposite to the first surface;', 'a plurality of first holes, penetrating the intermediate plate from the first surface to the second surface; and', 'a plurality of second holes, penetrating the intermediate plate from the first surface to the second surface;, 'an intermediate plate, connected to the positioning member, and comprising a plurality of first microneedles, passing through the first holes; and', 'a first metal connecting portion, connected to the first microneedles;, 'a first microneedle assembly, disposed between the positioning member and the intermediate plate, and comprising a plurality of second ...

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Номер записи: 80
19-01-2017 дата публикации

Method, system, and apparatus for dermatological treatment

Номер: US20170014305A1
Автор: Jongju Na, Merle Richman
Принадлежит: Jongu Na

Embodiments of dermatological cell treatment are described generally herein. Other embodiments may be described and claimed.

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Номер записи: 81
19-01-2017 дата публикации

MICRONEEDLE PREPARATION ADMINISTRATION MEMBER FOR PLACEMENT OF OBJECTIVE SUBSTANCE IN DERMIS, AND APPARATUS FOR QUICK ADMINISTRATION OF MICRONEEDLE PREPARATION

Номер: US20170014608A1
Автор: Ono Ichiro, Takada Kanji
Принадлежит:

The invention is a microneedle preparation administration apparatus comprising: a guide tube; a pedestal in which at least a part thereof including a front end surface is housed within the guide tube and slides in length direction; and driving means for driving the pedestal toward a front end part of the guide tube, and microneedle preparations being to be attached to the front end surface of the pedestal. 1. A microneedle preparation administration apparatus comprising:a guide tube having an open front end part and an at least partially closed rear end part;a pedestal having a front end surface perpendicular and flat to length direction of the guide tube, in which at least a part thereof including the front end surface is housed within the guide tube and slides in the length direction; anddriving means for driving the pedestal toward the front end part of the guide tube, andmicroneedle preparations being to be attached to the front end surface of the pedestal, and the microneedle preparations being to be pressed out from the front end part of the guide tube, whereinthe microneedle preparation has a first portion having a tip end part and containing an objective substance, and a second portion having a bottom part and not containing the objective substance, and{'sup': '2', 'the front end surface of the pedestal is struck on skin at a collision pressure of 5 N to 200 N per 1 cm.'}2. The microneedle preparation administration apparatus according to claim 1 , wherein the first portion of the microneedle preparation contains a strength regulator.3. The microneedle preparation administration apparatus according to claim 1 , wherein the guide tube has a cross-sectional surface perpendicular to the length direction of polygonal shape.4. The microneedle preparation administration apparatus according to claim 3 , wherein the polygonal shape is quadrangle.5. The microneedle preparation administration apparatus according to claim 1 , wherein the front end surface of the ...

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Номер записи: 82
19-01-2017 дата публикации

IONTOPHORETIC APPARATUS AND METHOD FOR MARKING OF THE SKIN

Номер: US20170014610A1
Автор: Imran Mir
Принадлежит:

Embodiments provide apparatus and methods for producing markings in the skin. One embodiment provides an apparatus for marking the skin comprising a housing and reservoir for storing a skin colorant. An electrode is positioned within the housing so as to be electrically coupled to the colorant in the reservoir and is configured to be coupled to a current source and return electrode. A colorant applicator having at least one fluid pathway is coupled to a housing distal end. The applicator proximal end is positioned such that the fluid pathway is coupled with the reservoir. The applicator distal end applies colorant to the skin surface through the fluid pathway as the applicator is moved across the skin. The electrode delivers current from the current source to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin. 1a housing having a proximal end, a distal end and a reservoir for storage of a skin colorant, a portion of the housing configured to be held in a hand of a user;a first electrode positioned within the housing, a portion of the first electrode positioned to be electrically coupled to the skin colorant in the reservoir, the first electrode configured to be electrically coupled to a current source and a second electrode; anda colorant applicator coupled to the distal end of the housing, the colorant applicator having a proximal end, a distal end and at least one fluid pathway, the proximal end of the colorant applicator positioned such that the at least one fluid pathway is coupled with the reservoir, the distal end of the colorant applicator configured to apply the skin colorant to the skin surface through the at least one fluid pathway as the colorant applicator is moved across the skin; andwherein the first electrode is configured to deliver current to the skin to transport charged pigment elements of the skin colorant into the skin using an electromotive driving ...

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Номер записи: 83
18-01-2018 дата публикации

Internal Tissue Heating Apparatus

Номер: US20180014871A1
Автор: Lewis Donald Carson, Mitra Hirak
Принадлежит:

A machine holds a plurality of RF beam generators which all point at a particular location. A patient with a target volume of tissue to be treated by heat is held immobile such that the target is located at the point all the RF beams traverse. The RF beams traverse that point and the resultant generated heat treats the target. No two or more RF beams traverse any other location in the patient's body. Since each individual RF beam is too weak to cause damage, the non-targeted tissues of the patient are unharmed. 1. A machine comprising multiple RF beam generators where all said RF beam generators are spatially oriented for their beams all to pass through a region of space , called the focus , which is completely contained within some sphere of some diameter greater than or equal to 0.001 mm , and less than or equal to 10 cm.2. A method of the machine of where:a) a patient with a piece of tissue to be treated by heat, called a target, is positioned such that the focus of said RF beam generators in said machine all pass through said target;b) the machine energizes said RF beam generators, which produce RF beams which converge at said target;for the purpose of providing heat treatment to said target without affecting other tissue in said patient.3. The method of where nanoparticles are introduced into the patient's body and some of these nanoparticles are activated by the machine producing heat; thereby treating the target more effectively than heat alone would.4. The method of where a plurality of chemotherapy drugs is introduced into the patient's body and some of these nanoparticles are activated by the machine producing heat; thereby treating the target more effectively than heat alone would.5. The machine of where said machine comprises a plurality of programmable automata claim 1 , where said programmable automata control said machine.6. The machine of where each said RF beam generator is attached to the framework of said machine in a manner that its angular ...

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Номер записи: 84
18-01-2018 дата публикации

Microprojection array applicator and method

Номер: US20180015271A1
Автор: JUNGER Michael Carl, LEMAIRE Pierre Armand Vincent
Принадлежит:

The present invention relates to applicators for administering microprojection arrays to skin and methods of administering microprojection arrays. One embodiment of the present invention is a device for applying a microprojection array to a skin surface comprising: a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face a flexible section that when collapsed actuates the device; b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward; c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide; d) a microprojection array that is contacted by the cantilevered ring when the ring is activated; e) a skin contact membrane; and f) a skin contact applicator base that attaches to the housing. A further embodiment of the present invention also includes two or more cantilevered rings having a first and a last ring, wherein the cantilevered rings are stacked such that when the device is actuated the first ring is fired such that each successive ring is contacted by the preceding ring. 1. A device for applying a microprojection array to a skin surface comprising:a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face has a flexible section that when collapsed actuates the device;b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward;c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide;d) a microprojection ...

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Номер записи: 85
18-01-2018 дата публикации

MICRONEEDLE WITH POROUS COATING LAYER, MANUFACTURING METHOD THEREOF AND MICRONEEDLE PATCH WITH THE SAME

Номер: US20180015272A1
Автор: KIM Gyu Man
Принадлежит: Kyungpook National University Industry-Academic Cooperation Foundation

The present invention relates to a microneedle coated with a porous coating layer, a manufacturing method thereof and a microneedle patch with the same, which can secure a channel to deliver medicine in a surface of a needle body and improve an efficiency of collecting and delivering the medicine based on merits of a material. 1. A microneedle coated with a porous coating layer , comprising:a needle body hard enough to penetrate an outer skin layer; anda coating layer coated to surround the needle body,wherein the needle body is made of metal,wherein the coating layer comprises a plurality of communicating holes recessed or penetrated to be filled with medicine,wherein the plurality of communicating holes communicate with one another to form a moving path of the medicine,wherein the coating layer is made of a soft material comprising at least one of biocompatible polymer and biocompatible hydrogel; and water-soluble porogen different in state from the soft material,wherein the communicating holes are recessed or penetrated as the porogent is removed from the coating layer,wherein the porogen comprises at least one of phosphate buffer saline (PBS), water-soluble hydrogel, and salt,wherein the needle body is shaped like a horn or a column, a tip of which is formed by its material characteristic.2. The microneedle coated with the porous coating layer according to claim 1 , whereinthe biocompatible polymer comprises at least one of poly lactic-co-glycolic acid (PLGA) and poly lactic acid (PLA), andthe biocompatible hydrogel comprises at least one of poly ethylene glycol (PEG), poly ethylene glycol diacrylate (PEGDA), and poly ethylene glycol methyl ether acrylate (PEGMEA).3. A method of manufacturing a microneedle of which a needle body is coated with a coating layer claim 1 ,the method comprising:an emulsion producing operation of dissolving a soft material as a raw material of the coating layer in a solvent and mixing porogen with the dissolved soft material to ...

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Номер записи: 86
17-01-2019 дата публикации

Method and apparatus for skin stabilization and positioning

Номер: US20190015153A1
Автор: Dieter Manstein
Принадлежит: Individual

Exemplary embodiments of a method, device, and apparatus for positioning an apparatus on a location of a tissue. For example, a substantially rigid film over an area of tissue to be treated can be provided. The film can include a positioning arrangement that facilitates a particular spatial engagement with the apparatus. The exemplary method can further include applying a portion of the film to a portion of a surface of the tissue and positioning the apparatus at the location by the engagement of the film to the apparatus using the feature of the film.

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Номер записи: 87
21-01-2016 дата публикации

A microneedle patch

Номер: US20160015952A1
Автор: Masami Kusaka, Masao Nagao, Shigehiro Asano, Yasuhiro Hiraishi, Yoshihiro Omachi
Принадлежит: Takeda Pharmaceutical Co Ltd

The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

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Номер записи: 88
21-01-2016 дата публикации

Methods and Systems for Modulating Medicants Using Acoustic Energy

Номер: US20160015954A1
Автор: Barthe Peter G., Slayton Michael H.
Принадлежит:

This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.

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Номер записи: 89
17-01-2019 дата публикации

MICRONEEDLE TATTOO PATCHES AND USE THEREOF

Номер: US20190015650A1
Автор: Jaklenec Ana, Langer Robert S., McHugh Kevin J.
Принадлежит:

Microneedle patches have been developed that can be used to deliver therapeutic, prophylactic, diagnostic agents and/or dyes to the skin. The microneedles encapsulate the agent(s) to be delivered. These are formed of a biodegradable polymer that dissolves upon insertion into skin or tissue, so that the microneedles break off from the substrate forming the patch, remaining in the skin/tissue at the site of insertion. The patches are used to create a tattoo or to deliver therapeutic, prophylactic or diagnostic agent in combination with a tattoo. In one embodiment, the microneedle patch contains both vaccine and dye pigments to administer vaccine and record such administration in one application of the microneedle patch. 1. A microneedle array structure comprisinga flexible base element anda plurality of biodegradable microneedles each having a first end and a second sharpened end for penetration of skin,the microneedles extending outwardly from the base element at the first end of the microneedles,The microneedles comprising therapeutic, prophylactic and/or diagnostic agent and/or dye,wherein the microneedles are released from the base element within 15 minutes of administration into the skin.2. The microneedle array structure of wherein the therapeutic claim 1 , prophylactic or diagnostic agent and/or dye is microencapsulated prior to incorporation into the microneedles.3. The microneedle array structure of wherein the microneedles are formed of biodegradable polymer or a sugar composition.4. The microneedle array structure of wherein the dye is selected from the group consisting of inorganic nanocrystals claim 1 , lanthanide-based dyes claim 1 , other fluorophores claim 1 , and non-fluorescent imaging agents.5. The microneedle array structure of wherein the dye is carbon or a tattoo ink claim 1 , or a cosmetic ink.6. The microneedle array structure of any of wherein the dye is a near infrared imaging agent with an excitation wavelength and an emission wavelength in ...

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Номер записи: 90
17-01-2019 дата публикации

MICRONEEDLE PARTICLES, COMPOSITIONS, AND METHODS OF TREATMENT AND DELIVERING A SUBSTANCE OF INTEREST

Номер: US20190015651A1
Автор: Prausnitz Mark R., TADROS Andrew
Принадлежит:

Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue. 1. A microneedle particle comprising:a core structure; andone or more microneedles extending from the core structure, the one or more microneedles being structured to penetrate a biological tissue;wherein at least one of (i) the core structure, (ii) the one or more microneedles, and (iii) a spatial relationship between/among two or more of the microneedles is configured to prevent the entire microneedle particle from penetrating the biological tissue.2. The microneedle particle of claim 1 , wherein the microneedle particle comprises three microneedles claim 1 , four microneedles claim 1 , five microneedles claim 1 , six microneedles claim 1 , seven microneedles claim 1 , eight microneedles claim 1 , or ten microneedles extending from the core structure.3. The microneedle particle of claim 1 , wherein the one or more microneedles are planar microneedles.4. The microneedle particle of claim 1 , wherein the microneedle particle comprises three or more microneedles claim 1 , and at least one of the three or more microneedles is a non-planar microneedle.5. The microneedle particle of claim 1 , wherein each of the one or more microneedles independently has a length of about 10 μm to about 2 claim 1 ,000 μm.6. The microneedle particle of claim 1 , wherein each of the one or more microneedles independently has a length of about 100 μm to about 1 claim ...

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Номер записи: 91
17-01-2019 дата публикации

MICRONEEDLE SHEET

Номер: US20190015652A1
Автор: KOMINAMI Kazuya, Matsudo Toshiyuki, NISHIMURA Shinpei, OGURA Makoto, Tokumoto Seiji, Yamamoto Naoki
Принадлежит:

A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin. 19-. (canceled)10: A method for administrating an active component , comprising the steps of:preparing a microneedle sheet comprising a sheet including a principal surface extending along each of a longitudinal direction and a width direction, and a plurality of microneedles formed in the sheet, each of the plurality of microneedles having a tip and each said tip facing toward a first end of the sheet in the longitudinal direction;bending a first portion of the microneedle sheet not in contact with skin at a first acute angle along the width direction to raise, from the principal surface, thereby forming a first bent portion, at least one first microneedle located in the first bent portion;piercing the skin with the raised at least one first microneedle;with the raised at least one first microneedle piercing the skin, bending a second portion of the microneedle sheet not in contact with the skin at a second acute angle along the width direction to raise, from the principal surface, thereby forming a second bent portion, at least one second microneedle located in the second bent portion; andwith the raised at least one first microneedle piercing the skin, further piercing the skin with the raised at least one second microneedle.11: The method according to claim 10 , wherein the at least one first microneedle comprises a plurality of first microneedles claim 10 , andthe at least one second microneedle comprises a plurality of second microneedles.12: The method according to claim 10 , wherein the raising of the the at least one first microneedle comprises sequentially raising lines of the at least one first microneedle claim 10 , line by line claim 10 , and wherein the raising of the at least one ...

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Номер записи: 92
17-01-2019 дата публикации

SYSTEM AND METHOD FOR OPTOGENETIC THERAPY

Номер: US20190015677A1
Автор: Andersen Dan, Huang Joyce, Lundmark David C., Moore David, Stahler Greg
Принадлежит: Circuit Therapeutics, Inc.

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells. 1a. selecting a targeted tissue structure to be stimulated using illumination at a first subcutaneous location;b. providing an implantable light conductor configured to be permanently coupled between the first subcutaneous location and a second location selected such that extracorporeal photons directed toward the second location will be transmitted, at least in part, through the implantable light conductor to the targeted tissue structure.. A method for stimulating a tissue structure comprising light sensitive protein, comprising: This is a continuation application of U.S. patent application Ser. No. 15/803,473, filed on Nov. 3, 2017, which is a continuation of U.S. patent application Ser. No. 15/473,458, filed on Mar. 29, 2017, which is a continuation of U.S. patent application Ser. No. 14/449,081, filed on Jul. 31, 2014, which is a continuation application of International Application No. PCT/US2013/000262, filed on Nov. 21, 2013, which claims priority to U.S. Provisional Application Ser. No. 61/729,283, filed on Nov. 21, 2012. The foregoing applications are hereby incorporated by reference into the present application in their entirety. Priority to the aforementioned applications is hereby expressly claimed in accordance with 35 U.S.C. § § 119, ...

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Номер записи: 93
16-01-2020 дата публикации

Alignment of elongated particles in a particle delivery device

Номер: US20200016339A1
Автор: Armin R. Völkel, Ashish Pattekar, David K. Biegelsen, Eugene M. Chow, Mandana Veiseh
Принадлежит: Palo Alto Research Center Inc

A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.

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Номер записи: 94
16-01-2020 дата публикации

SKIN TREATMENT SYSTEMS AND METHODS USING NEEDLES

Номер: US20200016342A1
Автор: Ignon Roger
Принадлежит:

A device for treating the skin comprises a handpiece assembly having a distal end and a proximal end and a tip on the distal end of the handpiece assembly. The handpiece assembly includes a fluid delivery conduit, a waste conduit and/or an energy delivery conduit. Further, the tip is configured to contact the skin. The tip comprises a peripheral lip and a plurality of needles generally positioned within the peripheral lip. The tip also comprises at least one opening in fluid communication with a fluid delivery conduit, at least one opening in fluid communication with a waste conduit and/or an energy contact point in electrical communication with an energy contact point and energy conduit in the main body portion. The plurality of needles may be movable with respect to the peripheral lip through the use of a pneumatic or other force. 1 'a working end that includes a plurality of needles configured to engage and penetrate the skin and positioned on a plane parallel to a peripheral lip on the working end of the skin treatment device;', 'placing the working end of a skin treatment device against a portion of the skin of the patient wherein the skin treatment device comprisescausing the plurality of needles to penetrate the skin; andremoving the working end of the skin treatment device from the portion of skin.. A method for treating the skin of a patient, the method comprising: This application is a continuation application of U.S. patent application Ser. No. 14/211,089, filed Mar. 14, 2014, which claims the priority benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 61/788,420, filed Mar. 15, 2013, the entireties of both of which are hereby incorporated by reference herein.This application relates generally to skin treatment, and more specifically, to apparatuses, systems and methods for treating a person's skin using one or more needles and/or other penetrating members.Abrasion of the outer layer or epidermis of the skin is desirable to smooth or ...

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Номер записи: 95
15-01-2015 дата публикации

SUBSTANCE DELIVERY DEVICE AND SUBSTANCE DELIVERY METHOD USING THE SAME

Номер: US20150018755A1
Автор: CHEN MEI-CHIN, LAI Kuan-Ying, LIN Chun-Wei, LING Ming-Hung
Принадлежит:

A substance delivery device comprises a substrate, a plurality of dissolvable supporting structures and a plurality of carriers. The substrate attaches to a tissue. The dissolvable supporting structures are disposed on the substrate. The carriers are disposed on the dissolvable supporting structures and encapsulating substances. The present invention further provides a substance delivery method. The substance delivery device and the substance delivery method of present invention is advantageous for providing sustained release effect and rising the applicability of transdermal or transmucosal delivery techniques. 1. A substance delivery device comprises:a substrate attaching to a tissue;a plurality of dissolvable supporting structures disposed on the substrate; anda plurality of carriers disposed on the dissolvable supporting structures and encapsulating the substances.2. The substance delivery device according to claim 1 , wherein the dissolvable supporting structures can be dissolved in the tissue.3. The substance delivery device according to claim 1 , wherein the dissolvable supporting structures include polyvinylpyrrolidone claim 1 , polyvinyl alcohol claim 1 , γ-poly-glutamic acid claim 1 , hyaluronic acid claim 1 , starch claim 1 , gelatin claim 1 , or their combinations.4. The substance delivery device according to claim 1 , wherein substances are encapsulated in the dissolvable supporting structures claim 1 , and the substances are the same as the substances encapsulated in the carriers.5. The substance delivery device according to claim 1 , wherein substances are encapsulated in the dissolvable supporting structures claim 1 , and the substances are different from the substances encapsulated in the carriers.6. The substance delivery device according to claim 1 , wherein the carriers include a material capable of melting after exposure to a radiation.7. The substance delivery device according to claim 1 , wherein the components of the carriers include chitosan ...

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Номер записи: 96
21-01-2021 дата публикации

MULTI-TYPE MICRONEEDLE

Номер: US20210016070A1
Автор: CHO Sung Youn, CHOO Hyun Wook, CHUNG Woo Jin
Принадлежит:

A multi-type microneedle is proposed. The multi-type microneedle includes: a substrate part; a plurality of needle holes provided in the substrate part; a plurality of needle parts provided at a predetermined distance from each other along a circumferential direction of each of the needle holes on an area of the substrate part partitioning each of the needle holes; and a patch in contact with a user's skin while in contact with one surface of the substrate part, wherein since the needle parts is provided in a certain pattern around one needle hole by further having a drug injection part or a drug storage part capable of additionally supplying a drug, the needle parts are inserted into a predetermined area of the skin so that the drug to be delivered into the body may be rapidly diffused or permeated subcutaneously, and also an amount of the drug delivered is controlled. 1. A multi-type microneedle comprising:a substrate part;a plurality of needle holes provided in the substrate part;a plurality of needle parts provided at a distance from each other along a circumferential direction of each of the needle holes on an area of the substrate part partitioning each of the needle holes; anda patch in contact with a user's skin while in contact with a first surface of the substrate part.2. The multi-type microneedle of claim 1 , wherein the patch is provided with a drug injection part into which a drug to be delivered into a body is injected.3. The multi-type microneedle of claim 2 , wherein the drug injection part is provided on the patch in a form of an opening connected in communication with the plurality of needle holes provided in the substrate part.4. The multi-type microneedle of claim 3 , wherein at least one or more of the drug injection part is provided on the substrate part.5. The multi-type microneedle of claim 1 , wherein the substrate part is provided with a drug storage part in which a drug to be delivered into the body is stored.6. The multi-type microneedle ...

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Номер записи: 97
21-01-2021 дата публикации

Microneedles and Methods of Manufacture Thereof

Номер: US20210016071A1
Автор: GUO Xin Dong, Henry Sebastien, MCALLISTER Devin, Prausnitz Mark R.
Принадлежит:

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold. 1. A method for making microneedles , the method comprising:(a) providing a mold having an upper surface, an opposed lower surface, and an opening in the upper surface, wherein the opening leads to a first cavity proximal to the upper surface and to a second cavity below the first cavity, wherein the first cavity defines a primary funnel portion, and wherein the second cavity defines at least one microneedle;(b) filling at least the second cavity, via the opening in the mold, with a first material which comprises a substance of interest dissolved or suspended in a first liquid vehicle;(c) drying the first material in the mold to remove at least a portion of the first liquid vehicle to form at least a tip portion of a microneedle in the second cavity, wherein the tip portion comprises the substance of interest;(d) filling the first cavity, and the second cavity if any is unoccupied following steps (b) and (c), via the opening in the mold, with a second material which comprises a matrix material dissolved or suspended in a second liquid vehicle;(e) drying ...

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Номер записи: 98
21-01-2021 дата публикации

PROTECTIVE RELEASE SHEET FOR MICRONEEDLE PATCH

Номер: US20210016072A1
Автор: KAMIYAMA Fumio, Quan Ying-shu
Принадлежит:

Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum. 110-. (canceled)11. A microneedle patch system comprising:a microneedle array including a flexible substrate having first and second surfaces and microneedles provided on the first surface of the flexible substrate,an adhesive sheet adhered to the second surface of the flexible substrate, anda protective release sheet including one or more holes, wherein the microneedle array is held in the hole, andfurther comprising a protective case holding the protective release sheet so that the protective release sheet is sandwiched from above and below.12. The microneedle patch system according to claim 11 ,wherein the protective release sheet has one hole and one microneedle array is held in the hole of the protective release sheet.13. The microneedle patch system according to claim 11 ,wherein the protective release sheet has a plurality of holes and the plurality of microneedle arrays are held in the corresponding holes of the protective release sheet, respectively.14. The microneedle patch system according to claim 13 ,wherein the protective release sheet has one hole and one microneedle array is held in the corresponding hole of the protective release sheet.15. The ...

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Номер записи: 99
28-01-2016 дата публикации

MAGNETIC OPERATING MICROSCOPES AND METHODS OF TREATMENT AND DIAGNOSIS USING THE SAME

Номер: US20160022485A1
Автор: Goldberg Jeffrey L., GOLDBERG Roger A.
Принадлежит: EMMETROPE OPHTHALMICS LLC

In certain aspects, the present invention is directed to a device selected from (a) an operating microscope with an attached or attachable magnet and (b) a magnet that is configured for attachment to an operating microscope. In either case, the magnet is configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of a magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent lying within the tissue to a preferred location in the tissue. 1. A device selected from an operating microscope with an attached or attachable magnet and a magnet that is configured for attachment to an operating microscope , said magnet configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of an intraocular magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent positioned inside the tissue to a target location within the tissue.2. The device of claim 1 , wherein the magnetic field generated by the magnet ranges from 0.1 Tesla to 10.0 Tesla.3. The device of claim 1 , wherein the magnet is a rare earth magnet.4. The device of claim 1 , wherein the magnet is an electromagnet comprising a conductive coil and a source of electrical power in electrical communication with the conductive coil.5. The magnetic microscope of claim 1 , wherein a center the magnetic field of the magnet is centered with an optical axis of the microscope.6. The magnetic microscope of claim 1 , wherein the magnet is movable in a plane that is perpendicular to an optical axis of the microscope.7. The magnetic microscope of claim 1 , wherein the magnet is movable along an axis that is coincident with or parallel with an optical axis of the microscope.8. The magnetic microscope of claim 1 , wherein the peak centration of magnetic force induced by the magnet coincides with the ...

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