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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 4957. Отображено 100.
19-01-2012 дата публикации

Tracheostomy valves and related methods

Номер: US20120012116A1
Автор: Andrew J. Scherer, Rex O. Bare
Принадлежит: Passy Muir Inc

The embodiments of the present tracheostomy valves include a flexible diaphragm abutting a rib shaped substantially as a flat plate. Opposite the rib, the diaphragm abuts a boss and forms an uninterrupted seal therewith. As the tracheostomized patient inhales, the diaphragm bends about the rib, interrupting the seal and allowing air to flow smoothly into the valve. The features of the various embodiments contribute to a positive seal at all times except during inhalation, and low resistance to airflow through the valve during inhalation.

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Номер записи: 1
26-01-2012 дата публикации

Flow conditioner for a compact, low flow resistance aerosol generator

Номер: US20120017899A1
Автор: Donovan B. Yeates
Принадлежит: Individual

A flow conditioner for generating and diluting an aerosol comprising a first inlet adapted to receive a first volume flow of pressurized gas is described. A second inlet is adapted to receive a second volume flow of dilution gas and a third inlet adapted to receive a fluid to be converted into an aerosol. A nozzle is connected to the first and third inlet and has a nozzle orifice for outputting a first aerosol. A first dilution gas flow partitioner comprises a first set of openings penetrating the first flow partitioner and a second dilution gas flow partitioner that is spaced apart from the first dilution gas partitioner and comprises a second set of openings penetrating the second flow partitioner. The nozzle orifice is positioned in the proximity of the second dilution gas flow partitioner.

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Номер записи: 2
23-02-2012 дата публикации

Aerosol medication inhalation system

Номер: US20120042874A1
Автор: Kevin Grant Gowanlock, Robert Carlton Lynch, Thomas Gallem
Принадлежит: Pari Innovative Manufacturers Inc

An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

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Номер записи: 3
10-05-2012 дата публикации

Manifold & strainer assembly

Номер: US20120111778A1
Автор: Roger Wessels, William Gavlak
Принадлежит: Individual

A waste collection manifold assembly 10 has a housing 13 and a strainer 80. The housing 13 has at least one input port 12 A, 12 B, 12 C, 12 D for receiving waste collection products 1 through a vacuum line 4. The housing 13 includes an interior chamber 11 for receiving the waste collection products 1 and a fluid discharge port 14 for passing fluids 6 into a waste collection unit 2. The strainer 80 is located in the chamber 11 and above the fluid discharge port 14. The at least one inlet port 12 A, 12 B, 12 C, 12 D is positioned to open alongside an interior chamber wall 13 A of the housing 13 above the strainer 80 to direct the flow of the waste collection products 1 in a downward swirl along the interior chamber wall 13 A toward the strainer 80.

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Номер записи: 4
20-09-2012 дата публикации

Filter blood fluid channel methods, devices, and systems

Номер: US20120234746A1
Автор: Edward F. Leonard, John Howard, Thomas Qin
Принадлежит: Columbia University of New York

A risk of thrombogenesis is minimized in a tubular fiber membrane filter by flowing blood or other fluid through a header manifold that ensures a minimum shear rate on the wetted surfaces without flow reversal, stagnation volumes, or a shear rate that is too high. In an embodiment, fluid is conveyed into a header space and into a manifold face at a perimeter of the header space. The header space has a progressively decreasing clearance that is minimal to provide for substantial shear rate and decreasing toward a minimum clearance in a region that is remote from the perimeter and vented by openings to the microtubular membrane fibers. Other features and embodiments are described.

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Номер записи: 5
29-11-2012 дата публикации

Dispenser and method for entraining powder in an airflow

Номер: US20120298106A1
Автор: Johan Remmelgas, Marten Svensson, Orest Lastow, Per Arne Kjellgren
Принадлежит: AstraZeneca AB

The disclosure relates to a device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.

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Номер записи: 6
20-12-2012 дата публикации

Applying shear stress for disease treatment

Номер: US20120323223A1
Автор: Abbas Hassan, Aziz Hassan, Gregory G. Borsinger, Rayford G. Anthony
Принадлежит: HRD Corp

A system for applying shear stress ex-situ to a fluid. A method of preparing a fluid for intravenous administration to a patient. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient.

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Номер записи: 7
07-02-2013 дата публикации

Dose delivery device for inhalation

Номер: US20130032144A1
Автор: Andrew Miller, Richard L. Miller
Принадлежит: Manta Devices LLC

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

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Номер записи: 8
06-06-2013 дата публикации

Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain

Номер: US20130142868A1
Автор: John D. Hoekman, Rodney J.Y. Ho
Принадлежит: UNIVERSITY OF WASHINGTON

Methods of delivering a pharmaceutical compounds directly to the olfactory epithelium of a mammal by providing a pharmaceutical aerosol suspension comprising an aerosol and the pharmaceutical compound; aerosolizing the suspension to generate a stream of droplets, the stream having a rotational component, and, delivering the droplets directly to the olfactory epithelium, wherein at least 15% of the droplets are delivered directly to the olfactory deposition. The pharmaceutical compound may be encapsulated within a liposome nanoparticle.

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Номер записи: 9
25-07-2013 дата публикации

Acoustic pressure inducers and methods for treatment of obstructive sleep apnea

Номер: US20130186399A1
Автор: Ephraim Gutmark, Liran OREN, Siddarth Khosia
Принадлежит: University of Cincinnati

Acoustic pressure inducers and methods for treating obstructive sleep apnea are disclosed. In one embodiment, an acoustic pressure inducer includes an actuator housing having an orifice, a tube having a first end and a second end, and a nasal cannula fluidly coupled to the second end of the tube. The first end of the tube is fluidly coupled to the orifice of the actuator housing such that a gap is present between the first end of the tube and the orifice. The nasal cannula is configured to be positioned proximate to nostrils of a user. The acoustic pressure inducer further includes a vibrating element within the actuator housing and a signal generator. The signal generator component is electrically coupled to the vibrating element and configured to provide an electronic signal to the vibrating element to cause the vibrating element to oscillate within the actuator housing and produce an acoustic jet of air that exits the orifice and enters a nasal passageway of the user through the nasal cannula.

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Номер записи: 10
01-08-2013 дата публикации

Nebulizer that is activated by negative inspiratory pressure

Номер: US20130192594A1
Автор: Robert E. Stephens, Stuart P. Miller, W. Robert Addington
Принадлежит: Pneumoflex Systems LLC

A nebulizer includes an air channel section and medication reservoir. An air line extends through the air channel section. A venturi nozzle is at its end and configured to form a low pressure mixing chamber. A vent is formed in the body and communicates with the air channel section and medication reservoir to vent the air channel section and medication reservoir to outside ambient air. A primary suction line extends from the medication reservoir to the low pressure mixing chamber through which medication is drawn upward and mixed with air passing through the venturi nozzle and nebulized for discharge. The vent is configured to vent the air channel section and medication reservoir to atmospheric pressure such that at standard temperature and pressure (STP), a differential pressure results between the venturi nozzle and medication reservoir such that no medication is drawn upward through the primary suction line.

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Номер записи: 11
12-09-2013 дата публикации

Connector for a respiratory mask and a respiratory mask

Номер: US20130233317A1
Автор: Geoffrey Crumblin, Joanne Elizabeth Drew, Michael Kassipillai Gunaratnam, Philip James Jenkinson, Susan Robyn Lynch
Принадлежит: ResMed Pty Ltd

A respiratory mask assembly for delivering breathable gas to a patient includes a frame and an elbow assembly. The frame has a front surface and a rear surface adapted in use to face the patient. The frame includes a main body providing an aperture therethrough for the introduction of breathable gas into a nasal breathing cavity. The elbow assembly is swivelably coupled to the front surface of the frame. The elbow assembly includes a swivel elbow that defines an intake port and an exhaust port separated from the intake port using a baffle. The elbow assembly includes an end portion that interfaces with the aperture of the frame.

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Номер записи: 12
24-10-2013 дата публикации

Flush Syringe Assembly With Controlled Pulsatile Flushing

Номер: US20130281941A1
Автор: Anthony J. Kosinski, Girum YEMANE TEKESTE, Nichola Charles
Принадлежит: Becton Dickinson and Co

Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the cathether are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

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Номер записи: 13
16-01-2014 дата публикации

Methods, Devices and Formulations for Targeted Endobronchial Therapy

Номер: US20140014103A1
Автор: Gerald C. Smaldone, Lucy B. Palmer
Принадлежит: Research Foundation of State University of New York

The present invention provides a method and novel devices for treating tracheobronchitis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In a preferred embodiment, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

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Номер записи: 14
06-02-2014 дата публикации

Delivery device and related methods

Номер: US20140034053A1
Автор: Andrew Jones, Richard L. Miller
Принадлежит: Manta Devices LLC

A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.

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Номер записи: 15
13-02-2014 дата публикации

Apparatus and Methods for Delivery of Fluid Injection Boluses to Patients and Handling Harmful Fluids

Номер: US20140046295A1
Автор: Aaron Hughes, Arthur E. Uber, III, David M. Griffiths, Frederick W. Trombley, III, John F. Kalafut, Julie Gulick, Kevin P. Cowan, L. George Siddoway, Larry McCutchan, Lisa M. Coates, Marc A. Mabie, Mark Trocki, Peter Twichell
Принадлежит: Medrad Inc

A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.

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Номер записи: 16
06-01-2022 дата публикации

Device and method for aerosolized delivering of substance to a natural orifice of the body

Номер: US20220001118A1
Автор: Daniel Shahaf, David NAPCHI, Iris Shichor
Принадлежит: SIPNOSE Ltd

A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

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Номер записи: 17
01-01-2015 дата публикации

Device For Administering A Powdered Medicament To A Patient By Inhalation

Номер: US20150000656A1
Автор: Stefan Mayer
Принадлежит: SANOFI SA

A device ( 1 ) for administering a powdered medicament to a patient by inhalation is described. The device ( 1 ) comprises a body ( 2 ), an internal housing ( 3 ) in the body ( 2 ), an inhalation channel ( 4 ), a mouthpiece ( 5 ), and a dose provisioning member ( 6 ). The dose provisioning member ( 6 ) comprises at least one cavity ( 7,7 a, 7 b, 7 c ) for accommodation of a powdered medicament, the dose provisioning member ( 6 ) further being enabled to adopt a first position in which the cavity ( 7,7 a, 7 b, 7 c ) is out of alignment with the inhalation channel ( 4 ) and a second position in which the cavity ( 7,7 a, 7 b, 7 c ) is in alignment with the inhalation channel ( 4 ). Each cavity ( 7,7 a, 7 b, 7 c ) is prefilled with a single dose ( 8,8 a, 8 b, 8 c ) of a powdered medicament, wherein the powdered medicament is solely stored in each cavity ( 7,7 a, 7 b, 7 c ) and the device ( 1 ) is free of a powder reservoir for storing a plurality of doses. A protective member ( 9 ) is provided within the housing ( 3 ), the protective member ( 9 ) being enabled to adopt a first position in which a part of the protective member ( 9 ) lies in the inhalation channel ( 4 ) such that the cross-section of the inhalation channel ( 4 ) is covered by a wall of the protective member ( 9 ) and to adopt a second position in which the protective member ( 9 ) does not lie in the inhalation channel ( 4 ) such that the cross-section of the inhalation channel ( 4 ) is not covered by a wall of the protective member ( 9 ).

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Номер записи: 18
07-01-2021 дата публикации

Remote smell technology

Номер: US20210000998A1
Автор: Guido Fridolin Verbeck
Принадлежит: University of North Texas

The present application relates to systems, methods, and computer-readable media for providing generating odors. In aspects, the disclosed methods may include generating, by a chemistry dispersion element, a signal configured to act upon a surface of a chemistry reservoir to disperse an odorous substance retained within the chemistry reservoir. The chemistry reservoir and the chemistry dispersion element may be disposed within a housing. The method also includes generating, by an air pump, a volume of air, and transporting, by an airflow pathway, the volume of air from the air pump to an air outlet. The volume of air passes through at least a portion of the housing as it flows through the airflow pathway from the air pump to the air outlet, and transports at least a portion of the odorous substance dispersed by the chemistry reservoir within the housing to the air outlet.

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Номер записи: 19
07-01-2021 дата публикации

ERGONOMIC AND ADJUSTABLE RESPIRATORY MASK ASSEMBLY WITH FRAME

Номер: US20210001073A1
Автор: GING Anthony Michael, Kwok Philip Rodney, MOORE Rachael Elizabeth, NASR Saad, PRICE Andrew Martin
Принадлежит:

A respiratory mask assembly for delivering breathable gas to a patient includes a frame having a front surface and a rear surface, opposite the front surface, and adapted in use to face the patient. The frame defines an inner wall and an outer wall extending from the rear surface, the inner and outer walls being spaced to define a channel therebetween. A cushion is removably attachable to the frame such that the cushion and frame are repeatably engagable with and disengagable from one another. The cushion includes a side wall to be inserted into the channel of the frame, the side wall having a first interlocking surface that engages a second interlocking surface provided in the channel when the cushion and frame are engaged with one another. The first and second interlocking surfaces interlock with one another to removably attach the cushion to the frame. 1. (canceled)2. A patient interface assembly for therapy of a patient having a breathing disorder , comprising:a frame with a central aperture by which a flow of pressurized breathable gas is introduced in use; anda cushion supported by the frame, the cushion being made of a material that is relatively softer than the frame;a hose to deliver the flow of pressurized breathable gas to the central aperture of the frame;an intermediate piece between the hose and the frame, the intermediate piece being releasably connected to the central aperture via a snap-action connection; and wherein each of the rear strap portions includes a rear strap end, and', 'wherein the front fabric material of the front strap portions includes stiffening support structure having a pair connector elements each having a slot to receive a respective one of the rear strap ends in a length adjustable manner, the stiffening support structure being formed of a relatively rigid material compared to the front fabric material, the stiffening support structure having a degree of flexibility in one direction such that variations in patient physiology ...

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Номер записи: 20
07-01-2016 дата публикации

AEROSOLIZATION SYSTEM WITH FLOW RESTRICTOR AND FEEDBACK DEVICE

Номер: US20160001018A1
Автор: Casey Michael Joseph, Fink Jim, Grehan Joesph Martin, Hyland Kieran James, Lillis Claire Elizabeth, MacLoughlin Ronan, Molloy Lisa, Mullins John Matthew
Принадлежит:

In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range. 1. An aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system , the aerosolization device comprising:a conduit having a mouthpiece end by which a user may cause an inspiratory flow through the conduit;an aerosol generator in communication with the conduit and comprising a vibratable mesh; and provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit; and', 'provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor., 'a restrictor disposed within the conduit, wherein the restrictor defines a plurality of apertures disposed along an outer periphery of the restrictor, the plurality of apertures being configured to2. The aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system according to claim 1 , the aerosolization device further comprising:an indicator mechanism that indicates to a user a state of a parameter of the inspiratory flow relative to a ...

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Номер записи: 21
07-01-2016 дата публикации

LIQUID NEBULIZATION SYSTEMS AND METHODS

Номер: US20160001019A1
Автор: Casey Michael Joseph, Fink Jim, Grehan Joesph Martin, Hyland Kieran James, Lillis Claire Elizabeth, MacLoughlin Ronan, Molloy Lisa, Mullins John Matthew, Smith Niall Scott
Принадлежит:

Embodiments provide aerosolization device for providing aerosolized medicament to user. The aerosolization device includes conduit, aerosol generator, fluid receiving chamber, restrictor within the conduit, and indicator mechanism. Conduit has an inner wall and a mouthpiece end for causing an inspiratory flow. Aerosol generator includes a vibratable mesh laterally offset from the inner wall. Fluid receiving chamber receives liquid medicament. At least a portion of chamber is tapered such that liquid medicament is directed onto vibratable mesh for aerosolization. Restrictor defines a plurality of apertures that provide increases in pressure differential that vary with inspiratory flow rate within conduit and provide relatively laminar flow downstream of restrictor. Indicator mechanism indicates a state of flow parameters relative to a predefined range. Aerosol generator is configured to aerosolize at least a portion of liquid medicament only when flow parameters of the inspiratory flow are within range. 1. An aerosolization device for providing aerosolized medicament to a user , the aerosolization device comprising:a conduit having an inner wall and a mouthpiece end by which a user may cause an inspiratory flow through the conduit;an aerosol generator in communication with the conduit and comprising a vibratable mesh, the vibratable mesh laterally offset from the inner wall;a fluid receiving chamber in communication with the aerosol generator for receiving a volume of a liquid medicament, wherein at least a portion of the fluid receiving chamber is tapered such that substantially all of the liquid medicament is directed onto the vibratable mesh for aerosolization; and provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit; and', 'provide a relatively laminar flow downstream of the restrictor plate compared to upstream of the restrictor plate;, 'a restrictor disposed within the conduit, wherein the restrictor defines ...

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Номер записи: 22
04-01-2018 дата публикации

DRY POWDER DRUG DELIVERY SYSTEM AND METHODS

Номер: US20180001039A1
Автор: Adamo Benoit, Kinsey P. Spencer, Laurenzi Brendan F., Smutney Chad C.
Принадлежит:

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity. 1. A medicament cartridge comprising:a powder container;a lid; andan internal volume,wherein the lid includes a deflector or stem protruding from an undersurface facing the internal volume to direct airflow entering the internal volume from a direction parallel to the lid to a substantially downward direction to a direction substantially parallel to the lid to a direction substantially perpendicular to the lid to exit the powder container.2. The medicament cartridge of claim 1 , wherein the dry powder medicament cartridge is configured to include a containment configuration and a dosing configuration.3. The medicament cartridge of claim 2 , wherein in the containment configuration the dry powder is sealed from outside air.4. The medicament cartridge of claim 2 , wherein in the containment configuration the dry powder is sealed from the deflector or stem.5. The medicament cartridge of claim 1 , wherein the airflow exits the medicament cartridge through the lid.6. The medicament cartridge of claim 1 , wherein the medicament cartridge includes a dry powder.7. The medicament cartridge of claim 6 , wherein the dry powder comprises a diketopiperazine or a pharmaceutically acceptable salt thereof.8. The medicament cartridge of claim 7 , wherein the diketopiperazine is of the formula 2 claim 7 ,5-diketo-3 claim 7 ,6-bis(N—X-4-aminobutyl)piperazine claim 7 , wherein X is selected from the group consisting of ...

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Номер записи: 23
05-01-2017 дата публикации

DRY POWDER INHALATION DEVICE

Номер: US20170000960A1
Автор: RICHARDSON Eric Carl
Принадлежит: Concentrx Pharmaceuticals, Inc.

Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient. 1. An apparatus , comprising:a body having an upper portion and a lower portion, the body defining a toroidal disaggregation chamber, a bottom portion of the toroidal disaggregation chamber being within the lower portion and containing a dry powder drug;a removable partition disposed between the upper portion and the lower portion, the partition retaining the dry powder drug within the bottom portion of the toroidal disaggregation chamber when the upper portion and lower portion are coupled together;an air intake passage configured to place an external volume in fluid communication with the toroidal disaggregation chamber when the partition is removed; andan exit passageway configured to place the external volume in fluid communication with the toroidal disaggregation chamber when the partition is removed such that upon inhalation by the patient on the exit passageway, air is drawn from the air intake passage to the toroidal disaggregation chamber and on to the exit passageway to convey the dry powder drug via the exit passageway to a patient.2. A method of using a single-dose inhalation device to deliver a pre-metered dry powder drug , comprising:removing a protective overwrap packaging from the inhalation device;removing a partition of the inhalation device by pulling an end of the partition ...

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Номер записи: 24
05-01-2017 дата публикации

FLUIDIC-CONTROLLED RESERVOIR CANNULA

Номер: US20170000966A1
Автор: Pacas Rebecca E., Tiep Brian L.
Принадлежит:

A reservoir cannula is described that has a static fluidic control structure, in that it does not employ a membrane or other moving parts. Furthermore, the reservoir is open to ambient air instead of being sealed. In use, the reservoir cannula enables storage of oxygen and oxygen-rich gas in a storage chamber as well as in and around the patient's nasal passages and nasopharynx, which enables high volume oxygen delivery to the patient early in the next inhalation. Consequently, patients using this delivery mode can carry a smaller and lighter portable oxygen container for ambulatory oxygen, because lower flow oxygen is required to meet their oxygenation needs. In addition, patients requiring a higher flow of oxygen can achieve oxygenation levels previously achieved only by high flow mask or high flow nasal oxygen systems. 1. A cannula for controlling delivery of gas , comprising:an outer shell having an outer surface exposed to ambient air and an inner surface defining a reservoir chamber;an exhaust aperture extending through the outer shell to the reservoir chamber and having an open surface area dimension;a static structure disposed within the reservoir chamber and including a fluidic controller having a nasal port; anda nasal prong fitted to the nasal port and extending through the exhaust aperture, wherein the nasal prong has an outer area dimension which is less than the open surface area dimension of the exhaust aperture to permit gas to escape from the cannula.2. The cannula of claim 1 , wherein the fluidic controller further includes a supply port and a collection port.3. The cannula of claim 2 , wherein the fluidic controller controls delivery of gas from the reservoir chamber and the supply port in response to a breathing cycle.4. The cannula of claim 2 , wherein the collection port is in communication with the reservoir chamber.5. The cannula of claim 4 , further comprising a collection tube having a proximal end fitted to the collection port and a distal ...

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Номер записи: 25
05-01-2017 дата публикации

A HUMIDIFIER FOR A RESPIRATORY THERAPY DEVICE

Номер: US20170000968A1
Автор: Bath Andrew Roderick, Doudkine Dmitri Anatolievich, Foote Roger Mervyn Lloyd, HARRINGTON Matthew Rolf, Huby Ronald James, Tang Zhuo Ran, Wu Nan Hai, Yang Quangang
Принадлежит:

A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick that encloses part of the flow path, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the wick or to detect condensation in the flow path. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier such as to control the build up of foreign matter on the wick. 1100-. (canceled)101. A humidifier for increasing an absolute humidity of a flow of air to be delivered to a patient's airways by a respiratory therapy device , the humidifier comprising:a reservoir configured to retain a first volume of water; an air inlet configured to receive the flow of air from a pressure device;', 'an air outlet configured to deliver the flow of air to a patient interface from the humidifier chamber with added humidity;', 'a flow path through the humidifier chamber for the flow of air;', 'a humidifier wick configured to retain a second volume of water and the humidifier wick having a profiled shape to substantially enclose at least a portion of the flow path for the flow of air in an axial direction of the flow path;', 'a heating element; and', 'an air flow baffle configured to lengthen at least a portion of the flow path for the flow of air through the humidifier chamber; and, 'a humidifier chamber comprisinga delivery mechanism configured to deliver a flow of water from the reservoir to the humidifier wick,wherein the heating element is configured to heat the humidifier wick to vaporise the second volume of water to add absolute humidity to the flow of air and the humidifier wick is removable from the humidifier ...

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Номер записи: 26
05-01-2017 дата публикации

Blower for breathing apparatus

Номер: US20170002830A1
Автор: Johannes Nicolaas Bothma
Принадлежит: Fisher and Paykel Healthcare Ltd

A blower for a breathing apparatus has a diffuser for increasing static pressure and/or reducing noise and/or mitigating pressure instabilities and/or managing reverse flow.

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Номер записи: 27
13-01-2022 дата публикации

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

Номер: US20220008669A1
Автор: Charles Eric Hunter, Chengjie LI, Christopher W. Maurer, Jack C. Hunter, John H. Hebrank, Louis Thomas Germinario
Принадлежит: Pneuma Respiratory Inc

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

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Номер записи: 28
08-01-2015 дата публикации

VENTILATOR SYSTEM

Номер: US20150007815A1
Автор: DESILVA Adrian D., Duquette Steven, Gonzalez Hector, Le Richard, Miller Jeffrey Harold, Valdez Raul, Vu Huy Thanh, Wang Chiun, WILLIAMS Malcolm R.
Принадлежит:

Described herein is a modular ventilator. The ventilator has modular flow control devices, which are connected to fluid inlet adapters. The modular flow control devices have sensors for controlling fluid flow through the modular flow control devices. The fluid inlet adapters are removable, and can include magnetic indicators, and the ventilator can identify the fluid from the magnetic indicator. The ventilator can also contain or be connected to a device having a low-noise blower. 1. A ventilator comprising: a housing defining an impeller cavity;', 'an impeller plate disposed within the impeller cavity and comprising an outside edge; and', 'one or more vanes disposed on the impeller plate and comprising a leading surface and a trailing surface connecting at a tip; and, 'a blower comprising a fixed magnetic field;', 'a drive coil configured to move within the fixed magnetic field in response to a low frequency signal and configured to receive a high frequency signal;', 'a detection coil adjacent the drive coil and configured to detect the high frequency signal in the drive coil, the detected high frequency signal corresponding to a position of the drive coil; and', 'a processor coupled to the high frequency source and the low frequency source and configured (i) to receive the detected high frequency signal form the detection coil and (ii) to adjust the low frequency signal to move the drive coil,, 'a flow control device comprisingwherein the blower is in fluid communication with the flow control device.2. The ventilator of claim 1 , wherein the blower is before the flow control device in a fluid path of the ventilator.3. The ventilator of claim 1 , wherein the blower is after the flow control device in a fluid path of the ventilator.4. The ventilator of claim 1 , further comprising a sensor configured to provide sensor information of the blower and the flow control device claim 1 , and a ventilation control system configured to send the sensor information to the flow ...

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Номер записи: 29
12-01-2017 дата публикации

AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER

Номер: US20170007787A1
Автор: Blair Julian Alexander, Buck Daniel, Hazenberg Jan Geert, Zeng Xian-Ming
Принадлежит:

An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor. 1. An airflow adaptor for a breath-actuated dry powder inhaler , the airflow adaptor comprising:a first conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the first conduit, and wherein the airflow adaptor further comprises at least one second conduit for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the first conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor, andwherein the distal end of the first conduit comprises a first circumferential flange and the second conduit is in the form of at least one aperture in the first circumferential flange.2. An airflow adaptor according to wherein a ratio of the sum of the cross-sectional areas of the at least one second conduit to the cross-sectional area of the first conduit is such that when a breath induced low pressure is applied to the distal end of the airflow adaptor at least 5% claim 1 , preferably at least 20% claim 1 , of the resulting airflow is through the at least one second conduit.3. An airflow adaptor according to wherein the first circumferential flange comprises two claim 1 , preferably four apertures.4. An airflow adaptor according to wherein the airflow adaptor comprises a second circumferential flange at the proximal end of the airflow adaptor claim 1 , ...

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Номер записи: 30
09-01-2020 дата публикации

Atomizer and aspiration device with atomization function

Номер: US20200008465A1
Автор: Yucheng Xiao
Принадлежит: Shenzhen Uwell Technology Co Ltd

An atomizer includes a central region, a marginal region, a liquid storage tank assembly defining a first hole, a base assembly including a base body including an accommodating room and inlet holes, and an atomization core assembly. The atomization core assembly includes an atomizing member including an atomizing room and a diverting member including a diverting room including a swirling flow region having a second hole and a straight flow region including first airflow holes and first diverting plates. Air flows into the accommodating room from the inlet holes, one part of the air flows through the second hole, the atomizing room, and the first hole in a swirling state, and forms a swirling flow in the central region; the other part of the air flows through the first airflow holes, the atomizing room, the first hole in a straight state, and forms a straight flow in the marginal region.

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Номер записи: 31
14-01-2021 дата публикации

Inhaler with aperatured porous support element

Номер: US20210008306A1
Автор: Daniele SANNA, Fabiana SPADARO, Gennaro CAMPITELLI, Gianpaolo D'AMBRA, Silvia CAPO
Принадлежит: PHILIP MORRIS PRODUCTS SA

An inhaler article includes a body extending from a mouthpiece end to a distal end with an endpiece element at the distal end. A capsule cavity is defined within the body and extends a cavity length. An air inlet region is between the endpiece element and the capsule cavity. The air inlet region has an air inlet and an air passageway extending from the air inlet to the capsule cavity. The air passageway has an inner diameter less than an inner diameter of the capsule cavity. A porous support element defines a downstream end of the capsule cavity. The porous support element includes one or more apertures extending the length of the porous support element.

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Номер записи: 32
14-01-2021 дата публикации

IHALER WITH VORTEX CAPSULE CAVITY

Номер: US20210008307A1
Автор: CAMPITELLI Gennaro, Sechi Gianluca, Spadaro Fabiana, ZUBER Gerard
Принадлежит:

An inhaler article includes a body extending along a longitudinal axis from a mouthpiece end to a distal end with an endpiece element at the distal end. A capsule cavity is defined within the body and extends along the longitudinal axis a cavity length. The capsule cavity includes a helical feature on or in an inner surface of the capsule cavity. The helical feature extends along the cavity length. An air inlet region is between the endpiece element and the capsule cavity. The air inlet region has an air inlet and an Nair passageway extending from the air inlet to the capsule cavity. A porous element defines a downstream end of the capsule cavity. A mouthpiece air channel extends from the capsule cavity, through the porous element to the mouthpiece end. 1. An inhaler article comprising:a body extending along a longitudinal axis from a mouthpiece end to a distal end;an endpiece element at the distal end;a capsule cavity having an inner surface defining a cylindrical space within the body and extending along the longitudinal axis a cavity length, the capsule cavity comprises a helical feature on or in the inner surface of the capsule cavity, the helical feature is a protrusion or channel extending along the cavity length;an air inlet region between the endpiece element and the capsule cavity, the air inlet region having an air inlet and an air passageway extending from the air inlet to the capsule cavity;a porous element defining a downstream end of the capsule cavity;a mouthpiece air channel extending from the capsule cavity, through the porous element to the mouthpiece end.2. The inhaler article according to claim 1 , wherein the helical feature is a groove or channel recessed into the inner surface of the capsule cavity.3. The inhaler article according to claim 1 , wherein the helical feature is a protrusion extending away from the inner surface of the capsule cavity.4. The inhaler article according to claim 1 , wherein the helical feature rotates about the inner ...

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Номер записи: 33
14-01-2021 дата публикации

HUMIDIFICATION CHAMBER AND APPARATUS AND SYSTEMS INCLUDING OR CONFIGURED TO INCLUDE SAID CHAMBER

Номер: US20210008325A1
Автор: BARNES Thomas Heinrich, BAUMANN Monika, Boyes Richard John, DEVA Karan, Fischer Christian Francis, GELL Zane Paul, GLAVES Rachael, Ip Bernard Tsz Lun, MCDERMOTT Gareth Thomas, Spence Callum James Thomas, VERDOOLD Vincent, WARNER Zach Jonathan
Принадлежит:

In one embodiment, there is provided a humidification chamber for use in a medical humidification system. The humidification chamber may comprise: a base and a top linked by a side wall to define the chamber, the chamber being configured to contain a volume of water; a gases inlet configured to receive a gases flow from a gases source; and a gases outlet, wherein the gases inlet is orientated relative to the side wall to introduce the gases flow to the humidification chamber at a direction substantially tangential to the side wall of the humidification chamber. 1. A humidification chamber for use in a medical humidification system , the humidification chamber comprising:a chamber comprising a base and a top linked by a side wall;a gases inlet configured to receive a gases flow from a gases source; anda gases outlet disposed on a top of the humidification chamber,wherein the gases inlet is configured to introduce the gases flow to the humidification chamber as a gases jet in a direction substantially tangential to the side wall of the humidification chamber.2. (canceled)3. The humidification chamber of claim 1 , wherein the side wall defines a substantially circular chamber claim 1 , when viewed from above.4. (canceled)5. (canceled)6. The humidification chamber of claim 3 , wherein the gases inlet comprises or is configured to receive a nozzle.7. The humidification chamber of claim 6 , wherein an inner diameter of the nozzle is configured to decrease along a length of the nozzle so as to increase a velocity of the gases flow prior to the gases flow being introduced to the humidification chamber.8. The humidification chamber of claim 6 , wherein the gases inlet comprises a substantially tubular body.9. The humidification chamber of claim 6 , wherein an inner diameter of the gases outlet is greater than an inner diameter of the gases inlet.10. The humidification chamber of claim 9 , wherein a ratio of the inner diameter of the gases outlet to the inner diameter of the ...

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Номер записи: 34
10-01-2019 дата публикации

NASAL DRY POWDER DELIVERY SYSTEM FOR VACCINES AND OTHER TREATMENT AGENTS

Номер: US20190009040A1
Автор: Bagley Mark C., Barry James J., Friets Eric M., Knaus Darin A., Moynihan Edward, Papania Mark J.
Принадлежит:

A nasal delivery device can include air-receiving section that has a first passageway therethrough to allow air to pass through the air-receiving section, a powder-reservoir receiving section sized to receive a powder reservoir, and a powder-delivery section that has a second passageway therethrough to allow aerosolized powder from the powder reservoir to pass through the powder-delivery section. The first passageway can have a first end and a second end, with the first end being further from the powder-reservoir receiving section and the second end being at or near the powder-reservoir receiving area. The second end of the air-receiving section can include a flattened region so that air exiting the air-receiving section has a generally flattened profile. 1. A method of delivering an aerosolized treatment agent to a subject , the method comprising:attaching a powder reservoir containing a treatment agent to a nasal delivery device;positioning an air inlet end of the device into an air delivery source;positioning an exit end the device at least partially within a nostril of the subject;delivering air through a passageway in the air inlet end to the powder reservoir, the passageway comprising a flattened region so that air exiting the flattened region enters the powder reservoir with a generally flattened profile; anddelivering aerosolized treatment agent through the exit end of the device and into the nostril of the subject.2. The method of claim 1 , wherein the air delivery source comprises exhaled air and the air inlet end of the device is positioned in the subject's mouth.3. The method of claim 1 , wherein the act of attaching the powder reservoir to the device comprises attaching a lip of the powder reservoir to one or more grooves on the device.4. The method of claim 3 , wherein the act of attaching the powder reservoir to the device further comprises piercing a frangible cover of the powder reservoir with at least one piercing member that extends from the ...

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Номер записи: 35
03-02-2022 дата публикации

Apparatus and Method for Producing A Flow Profile

Номер: US20220031973A1
Автор: Mahé Laure, Matthewson Peter
Принадлежит:

A method for generating a flow profile of an inhalation device is described. The method comprises the step of measuring acoustic emissions induced by inhalation flow through the inhalation device. The method further comprises the step of detecting peak frequencies in the measured acoustic emissions and generating a flow profile based on the detected peak frequencies. A corresponding device is also described. 120-. (canceled)21. A method for detecting acoustic emissions within an inhaler device having at least one chamber through which air may pass upon inhalation by a user of the inhaler , the method comprising the steps of:positioning an acoustic sensor and an inhaler device into spaced-apart proximity with each other, wherein said acoustic sensor is not physically coupled to the inhaler, and wherein the acoustic sensor is in electrical communication with a processor; andmeasuring acoustic emissions induced by a user generating an inhalation flow movement through the inhaler device; and generating a signal indicative of said movement.22. The method of wherein the signal indicative of said movement comprises a flow profile.23. The method of wherein the inhalation flow movement comprises a rotational flow.24. The method of wherein the flow profile comprises adherence monitoring.25. The method of wherein the acoustic sensor and inhaler are spaced apart by a distance of at least 0.1 meter.26. The method of wherein the acoustic sensor and inhaler are spaced apart by a distance of up to 1 meter.27. The method of wherein the acoustic sensor comprises a microphone.28. The method of wherein the microphone and processor are part of a mobile device.29. The method of wherein the mobile device comprises a smart phone.30. The method of wherein the mobile device comprises a computer.31. A method of training a patient in the correct use of an inhaler claim 28 , the method comprising claim 28 ,providing an inhaler device having at least one chamber through which air may pass upon ...

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Номер записи: 36
03-02-2022 дата публикации

Aerosol Generating Device Having Vapour-Cooling Passageway

Номер: US20220031978A1
Автор: Golovanova Tatiana, Hasegawa Takashi, Johaentges Thomas, ORTH Michael, Parsons Christopher Rory, Plattner Michael
Принадлежит: JT International S.A.

There is provided an aerosol generating device, comprising an inhalation outlet; a chamber for holding a material, the material capable of generating a vapour when heated; a heater for heating material held in the chamber; an air inlet connected by an air inlet passage to the chamber; a vapour-cooling module providing a fluidic connection between the chamber and inhalation outlet, the module configured to cool a vapour passing there through. In use, suction at the inhalation outlet causes air to enter the chamber via the air inlet, thereby transporting the vapour generated in the chamber through the vapour-cooling module to the inhalation outlet, such that the temperature of the vapour exiting the device through the inhalation outlet is substantially lower than the temperature of the vapour generated in the chamber. The aerosol generating device thereby provides a means whereby a vapour generated in the chamber is substantially cooled during transport from the chamber through the mouthpiece to the user. 1. An aerosol generating device , comprising:a body having chamber for holding a material, the material capable of generating a vapour when heated;a heater for heating the material held in the chamber; anda vapour-cooling module having a vapour-cooling passageway including a first portion and a second portion, the vapour-cooling module including:a cap defining an inhalation outlet;a connecting member defining a first portion of the vapour-cooling passageway; andan internal back plate arranged within the cap defining an aperture, the internal back plate and the cap collectively defining the second portion of the vapour-cooling passageway, the aperture providing a fluid connection between the first portion of the vapour-cooling passageway and the second portion of the vapour-cooling passageway,wherein the vapour-cooling passageway has a length arranged to reduce a temperature of the vapour as the vapour is transported through the vapour-cooling passageway from the ...

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Номер записи: 37
03-02-2022 дата публикации

Nasal drug delivery system

Номер: US20220032022A1
Автор: Adam Gold, Ashley Seehusen, Jonathan Toma, Shira KOSS
Принадлежит: Leland Stanford Junior University

Devices, systems, and methods for treating chronic rhinosinutisits (CRS) are described herein. The devices can have a guide member defining at least one lumen therethrough. A drug delivery component is advanced through the lumen to deliver a substance to the sino-nasal cavity of a patient. Once the drug delivery component is positioned at the desired area in the sino-nasal cavity, a user actuates the system to deliver the substance to the target area. Actuation of the system delivers the substance to the middle meatus, osteo-meatal complex, or other areas within the sino-nasal cavity of the patient.

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Номер записи: 38
19-01-2017 дата публикации

SURGICAL SUCTION DEVICE THAT USES POSITIVE PRESSURE GAS

Номер: US20170014555A1
Автор: Jackson James, LEEFLANG Elisabeth Jacques, Minskoff Noah Mark, Philippsen Aaron Olafur Laurence
Принадлежит:

A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end. 1. A method of passively generating a suction flow with a device having a central axis and comprising a pressurized gas port , a conduit , and a hollow segment , the method comprisingreceiving a pressurized gas flow into the pressurized gas port;directing the pressurized gas flow from the pressurized gas port into the conduit, wherein the conduit is positioned at an angle relative to the central axis;directing the flow of the pressurized gas through the conduit and into the hollow segment;generating an area of low pressure within the device with the flow of pressurized gas through the hollow segment; andgenerating the suction flow with the generated area of low pressure within the device.2. The method of claim 1 , comprising adjusting a width of the conduit.3. The method of claim 2 , comprising adjusting claim 2 , due to the adjusted width of the conduit claim 2 , a liquid suction rate of the device.4. The method of claim 2 , comprising adjusting claim 2 , due to the adjusted width of the conduit claim 2 , a volumetric ratio of gas suction rate to liquid suction rate of the device.5. The method of claim 2 , wherein the conduit is ...

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Номер записи: 39
19-01-2017 дата публикации

Surgical suction device that uses positive pressure gas

Номер: US20170014558A1
Автор: Aaron Olafur Laurence Philippsen, Elisabeth Jacques Leeflang, James Jackson, Noah Mark Minskoff
Принадлежит: Integrated Surgical LLC

A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end.

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Номер записи: 40
19-01-2017 дата публикации

Surgical suction device that uses positive pressure gas

Номер: US20170014560A1
Автор: Aaron Olafur Laurence Philippsen, Elisabeth Jacques Leeflang, James Jackson, Noah Mark Minskoff
Принадлежит: Conmed Corp, Integrated Surgical LLC

A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end.

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Номер записи: 41
17-01-2019 дата публикации

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Номер: US20190015323A1
Автор: BELL Robert Gerard, CRYSTAL Roger, KEEGAN Fintan, WEISS Michael Brenner
Принадлежит:

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 122.-. (canceled)23. A method of preventing the use of naloxone to titrate opioid receptor occupancy , the method comprising:delivering a spray from a pre-primed device into a nostril of a patientwherein the spray delivers a 25-200 μL spray of a pharmaceutical solution comprising between about 4 mg and about 10 mg naloxone hydrochloride of a hydrate thereof, an isotonicity agent, and between about 0.005% and about 0.15% (w/v) of benzalkonium chloride.24. The method of claim 23 , wherein the spray consists of a mist in which no more than about 10% of the droplets have a diameter less than 10 μm.25. The method of claim 24 , wherein the pharmaceutical solution is delivered in a round spray plume with an ovality ratio less than about 2.0 when measured at 3 cm.26. The method of claim 25 , wherein the isotonicity agent is present in an amount between about 0.2% and about 1.2% (w/v).27. (canceled)28. The method of claim 26 , wherein the pharmaceutical solution further comprises between about 0.1% and about 0.5% (w/v) of a stabilizing agent and an amount of an acid sufficient to achieve a pH between about 3.5 and about 5.5.29. The method of claim 28 , wherein:the isotonicity agent is sodium chloride;the stabilizing agent is disodium edetate; andthe acid is hydrochloric acid.30. The method of claim 29 , wherein the pharmaceutical solution comprises:about 4.4% (w/v) naloxone hydrochloride dihydrate;about 0.74% (w/v) sodium chloride;about 0.01% (w/v) benzalkonium chloride; andabout 0.2% (w/v) disodium edetate.31. The method of claim 30 , wherein the device has a single reservoir containing approximately 125 μL of the pharmaceutical solution.32. The method of claim 23 , wherein the spray delivers about 4 mg ...

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Номер записи: 42
16-01-2020 дата публикации

Insert Piece For A Blood Tubing Set to Promote Mixing An Infusion Solution With A Further Fluid

Номер: US20200016314A1
Автор: Häcker Jürgen, Klewinghaus Jürgen
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present disclosure relates to an insert piece for a blood tubing set. The insert piece includes at least a first connection site for connecting a first tubing portion of the blood tubing set to the insert piece, and a second connection site for connecting a second tubing portion of the blood tubing set to the insert piece. The insert piece also includes a third connection site for connecting a third tubing portion of the blood tubing set to the insert piece, and a main line for forwarding a first liquid through the insert piece. The main line is in fluid communication with the first connection site and with the second connection site. The insert piece also includes a secondary line for forwarding a second liquid into the main line. The secondary line is in fluid communication with the third connection site. 117-. (canceled)18. An insert piece for a blood tubing set , the insert piece comprising:a first connection site for connecting a first tubing portion of the blood tubing set to the insert piece;a second connection site for connecting a second tubing portion of the blood tubing set to the insert piece;a third connection site for connecting a third tubing portion of the blood tubing set to the insert piece;a main line for conducting a first fluid through the insert piece, wherein the main line is in fluid communication with the first connection site and with the second connection site; anda secondary line for conducting a second fluid into the main line, wherein the secondary line is in fluid communication with the third connection site, and wherein the secondary line is in fluid communication with the main line in an intermediate portion of the insert piece, the intermediate portion being arranged between the first connection site and the second connection site;wherein the first connection site comprises a perfusable lumen having a first cross section area; the second connection site comprises a perfusable lumen having a second cross section area; the ...

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Номер записи: 43
21-01-2021 дата публикации

Dry Powder Inhaler

Номер: US20210016024A1
Автор: Esteve Victor
Принадлежит: Emphasys Importadora Exportadora e Distribuidora Ltda.

A dry powder inhaler for at least two capsules containing dry powder is provided, the dry powder inhaler including: At least two capsule chambers each capsule chamber for receiving one of the capsules; a mouth piece with a mouth portion comprising a distal opening; and a duct structure between the distal opening of the mouth piece and the at least two capsule chambers, wherein the duct structure comprises at least two primary ducts, wherein the distal opening of the mouth piece leads into the at least two primary ducts, and wherein each one of the at least two primary ducts leads into the corresponding one of the at least two capsule chambers. 1. A dry powder inhaler for at least two capsules containing dry powder , the dry powder inhaler comprising:at least two capsule chambers each capsule chamber for receiving one of the capsules;a mouth piece with a mouth portion comprising a distal opening and a main body, which comprises a duct structure; andthe duct structure of the mouth piece arranged between the distal opening of the mouth piece and the at least two capsule chambers, wherein the duct structure comprises at least two primary ducts, wherein the distal opening of the mouth piece leads into the at least two primary ducts, and wherein each one of the at least two primary ducts leads into the corresponding one of the at least two capsule chambers.2. The dry powder inhaler according to claim 1 , wherein the duct structure is Y-shaped claim 1 , and wherein the duct structure comprises a secondary duct between the distal opening of the mouth piece and the at least two primary ducts.3. The dry powder inhaler according to claim 2 , wherein the secondary duct comprises a secondary cross-sectional area claim 2 , which equals or is less than a sum of primary cross-sectional areas of the at least two primary ducts.4. The dry powder inhaler according to claim 2 , wherein the length of the secondary duct is equal or greater than the length of one of the primary ducts.5. ...

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Номер записи: 44
21-01-2021 дата публикации

INFANT CPAP DEVICE, INTERFACE AND SYSTEM

Номер: US20210016031A1
Автор: Evans Alicia Jerram Hunter, Porter Rachael, Spence Callum James Thomas, White Craig Karl
Принадлежит:

An infant positive airway pressure (PAP) or continuous positive airway pressure (CPAP) device and related patient interface and system, which can provide a flow of breathing gas to the patient interface. The device can be incorporated into the patient interface and includes at least one interior passage in the shape of a nozzle having a throat, a first portion upstream of the throat and a second portion downstream of the throat relative to the flow of breathing gas. The passage has a vent opening within the second portion and the interior passage defines a continuously curved surface extending between the throat and the vent opening. The second portion of the nozzle preferably is divergent and the first portion can be convergent or non-convergent (e.g., constant cross-section). 123-. (canceled)24. A positive airway pressure device comprising:a conduit portion defining an interior passage having a first end and a second end, wherein the interior passage comprises an asymmetric transition surface portion, a first portion upstream of the asymmetric transition surface portion, and a second portion downstream of the asymmetric transition surface portion,wherein the conduit portion comprises a vent opening in communication with the interior passage between the first end and the second end.25. The positive airway pressure device of claim 24 , wherein the asymmetric transition surface portion diverges toward the second portion.26. The positive airway pressure device of claim 24 , wherein the asymmetric transition surface portion converges from the first portion.27. The positive airway pressure device of claim 24 , wherein an exit of a jet of gases from the asymmetric transition surface portion creates an unstable jet within the second portion.28. The positive airway pressure device of claim 24 , wherein the asymmetric transition surface portion is asymmetric about at least one axis or plane that passes through the interior passage.29. The positive airway pressure device of ...

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Номер записи: 45
25-01-2018 дата публикации

FLOW COMPONENT PARTICULARLY FOR HAEMODIALYSIS MEDICAL LINES

Номер: US20180021502A1
Автор: GUALA Gianni
Принадлежит: Industrie Borla S.p.A.

A flow component particularly for haemodialysis medical lines includes a duct having a first and a second end tubular connector coaxial to each other and designed to be connected to the line, and an intermediate tubular connector of the female luer type arranged orthogonally to the duct. A hollow elastic element substantially extends along the entire intermediate tubular connector and the body is internally configured so that, in use, the flow along the duct is partly diverted towards the intermediate tubular connector and introduced with a swirling motion along the cavity of the hollow elastic element. 1. A flow component , particularly for haemodialysis medical lines , comprising:a body defining a duct having a first and a second end tubular fitting coaxial to each other and designed to be connected to the line, andan intermediate tubular connector of the female luer type arranged orthogonally to the duct between said tubular fittings and containing a valve device,wherein said valve device is formed by an elastic hollow element which normally keeps said intermediate tubular connector closed, said elastic hollow element elastically deformable following the coupling of the intermediate tubular connector with a complementary male luer connector, wherein the hollow elastic element substantially extends over the entire intermediate tubular connector and said body is internally configured so that, in use, the flow along said duct is partially diverted towards the intermediate tubular connector and introduced with a swirling motion along the cavity of said elastic hollow element.2. Flow component according to claim 1 , wherein the intermediate tubular connector is delimited claim 1 , on the side of said duct claim 1 , by a wall for supporting the elastic hollow element claim 1 , said wall being formed with two juxtaposed by-pass apertures located respectively upstream and downstream of the elastic hollow element with respect to the flow within the duct claim 1 , said ...

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Номер записи: 46
25-01-2018 дата публикации

Unit for the micronization and dosage of solid active agents

Номер: US20180021527A1
Автор: Tamas KOKAI
Принадлежит: Individual

The invention relates to a unit for the micronization of a solid active agent, such as a salt, preferably table salt (NaCI), for inhalation, comprising a micronizer driven by a motor. The unit according to the invention is characterised in that micronization is performed by a unit constituted by a closed rotary drum ( 2 ) receiving a solid active agent having the same grain size, preferably 0.1-4 mm, as table salt (NaCI), where the wall surfaces of the micronizer unit are made at least in part of a material having a filtering capacity of 0.1-1000 μm, the material preferably being a mesh-like or microperforated material. A further unit according to the invention is characterised in that the micronizer consists of a rotary block ( 23 ) made of the active agent, a friction block ( 24 ) adapted to be in frictioning relation with the rotary block, and a clamping mechanism ( 25 ) adapted for holding the friction block ( 24 ) in position and for clamping the friction block ( 24 ) to the rotary block ( 23 ), the micronizer being disposed in a closed housing ( 11 ), and the wall surfaces of the housing ( 11 ) being at least in part made of a material having a filtering capacity of 0.1-1000 μm.

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Номер записи: 47
25-01-2018 дата публикации

Ergonomic and adjustable respiratory mask assembly with frame

Номер: US20180021537A1
Автор: Andrew Martin Price, Anthony Michael Ging, Philip Rodney Kwok, Rachael Elizabeth Moore, Saad Nasr
Принадлежит: ResMed Pty Ltd

A respiratory mask assembly for delivering breathable gas to a patient includes a frame having a front surface and a rear surface, opposite the front surface, and adapted in use to face the patient. The frame defines an inner wall and an outer wall extending from the rear surface, the inner and outer walls being spaced to define a channel therebetween. A cushion is removably attachable to the frame such that the cushion and frame are repeatably engagable with and disengagable from one another. The cushion includes a side wall to be inserted into the channel of the frame, the side wall having a first interlocking surface that engages a second interlocking surface provided in the channel when the cushion and frame are engaged with one another. The first and second interlocking surfaces interlock with one another to removably attach the cushion to the frame.

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Номер записи: 48
23-01-2020 дата публикации

Head-Only and/or Whole Body Inhalation Exposure Chamber

Номер: US20200022795A1
Автор: Anderson Jaime B., Bailey Mark M., Bowen Larry E., Haupt Brett R., Staymates Matthew E.
Принадлежит:

At least one embodiment of the invention provides a system comprising an inhalation exposure chamber and an aerosol delivery line connected to the inhalation exposure chamber. The aerosol delivery line is configured to produce a bi-directional and symmetrical presentation of aerosol to the inhalation exposure chamber. A laminar flow element is configured to create an ante-chamber where complete and turbulent mixing of the aerosol occurs. A radial exhaust and the laminar flow element enable laminar flow of the aerosol through the inhalation exposure chamber. 1. A system comprising:an inhalation exposure chamber having an ante-chamber;an aerosol delivery line connected to said inhalation exposure chamber, said aerosol delivery line configured to produce a bi-directional and symmetrical presentation of aerosol to said inhalation exposure chamber;a laminar flow element defining the ante-chamber where complete and turbulent mixing of the aerosol occurs; anda radial exhaust having a plurality of tubes extending radially out from a central hub, andwherein said radial exhaust and said laminar flow element enable laminar flow of the aerosol through said inhalation exposure chamber.2. The system according to claim 1 , wherein said aerosol delivery line is centrally located at a top of said inhalation exposure chamber claim 1 , wherein said laminar flow element is located below said aerosol delivery line claim 1 , andwherein said radial exhaust is centrally located at a bottom of said inhalation exposure chamber.3. The system according to claim 1 , further comprising at least one sample collection port located at a midpoint of a wall of said inhalation exposure chamber and below said laminar flow element.4. The system according to claim 1 , wherein said laminar flow element includes a sheet having a plurality of perforations.5. The system according to claim 1 , further including at least one additional laminar flow element claim 1 , said at least one additional laminar flow ...

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Номер записи: 49
04-02-2016 дата публикации

SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS

Номер: US20160030647A1
Автор: Franano F. Nicholas
Принадлежит:

A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein. 1. A method for creating an arteriovenous fistula or an arteriovenous graft in a human patient , the method comprising:fluidly connecting one end of a pump-conduit assembly to a donating vein;fluidly connecting another end of the pump-conduit assembly to an accepting vein;pumping deoxygenated blood from the donating vein into the accepting veinpumping deoxygenated blood from the donating vein into the accepting vein for a period of time sufficient to result in a persistent increase in the overall diameter of the accepting vein, wherein a mean pulse pressure in the conduit fluidly connected to the accepting vein is less than 20 mmHg; and,creating the arteriovenous fistula or arteriovenous graft in the patient using at least a portion of the accepting vein with the persistently-increased overall diameter.2. The method of claim 1 , wherein the patient is in need of an arteriovenous fistula or arteriovenous graft for hemodialysis.3. The method of claim 1 , wherein the pump-conduit assembly pumps blood at a rate between 50 ml/min and 1500 ml/min.4. The method of claim 1 , wherein the pump-conduit assembly pumps blood at a rate between 100 ml/min and 1000 ml/min.5. The method of claim 1 , wherein a wall shear stress in the accepting vein is greater than or equal to 0.76 Pa when the pump-conduit assembly is in operation.6. The method of claim 1 , wherein a wall shear stress in the accepting vein is between 0.76 Pa and 23 Pa when the pump-conduit assembly is in ...

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Номер записи: 50
04-02-2016 дата публикации

SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS

Номер: US20160030648A1
Автор: Franano F. Nicholas
Принадлежит:

A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein. 1. A system for increasing an overall diameter and a lumen diameter of a peripheral vein prior to creation of an arteriovenous fistula or an arteriovenous graft in a patient comprising: a pump configured to pump blood, having a pump inlet and a pump outlet;', 'a first conduit configured to carry blood having an inlet configured to fluidly connect to a donating vein or right atrium to remove the deoxygenated blood from the donating vein or to the right atrium, such first conduit comprising a catheter configured for insertion into a vein and advancement within the lumen of the vein, including into the right atrium; and an outlet fluidly connected to the pump inlet;', 'a second conduit configured to carry blood having an inlet fluidly connected to the pump outlet and an outlet to fluidly connect to a peripheral vein, such conduit comprising a first segment comprising a catheter and configured to connect to the pump outlet and a second segment configured to enable the creation of a surgical anastomosis between an end of the second segment and the peripheral vein using the end of the second segment to attach to the side of the peripheral vein; and, 'a pump-conduit assembly to remove deoxygenated blood from a donating vein or the right atrium and pump blood into the peripheral vein, the pump-conduit assembly includinga control unit to control the pump and pump deoxygenated blood into the peripheral vein at a rate to maintain a mean wall shear stress in the ...

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Номер записи: 51
01-02-2018 дата публикации

Respiratory mask arrangement as well as headband arrangement and respiratory gas evacuation device for a respiratory mask

Номер: US20180028775A1
Автор: Caspar Graff Stauffenberg, Harald Wolfgang VOGELE, Stefan Rolf Madaus
Принадлежит: ResMed R&D Germany GmbH

A respiratory mask arrangement that can be used in the framework of CPAP therapy for treating sleep-related disturbances, for example. The respiratory mask arrangement may include a sealing lip device to be placed on a facial surface of a mask user, a covering device which defines a mask interior in cooperation with the sealing lip device, and a respiratory gas conduit unit for delivering respiratory gas to the mask interior that is defined by the covering device and is connected to the nostril and/or oral opening of the mask user. At least some sections of the covering device may be embodied as an air-permeable structure.

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Номер записи: 52
24-04-2014 дата публикации

Infusion Catheter Tip for Biologics with Reinforced External Balloon Valve

Номер: US20140114239A1
Автор: Nabil Dib, Robert Edward Kohler
Принадлежит: Translational Biologic Infusion Catheter Llc

A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter to reduce particle flocculation. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid. A reinforcing member is employed to strengthen the catheter wall under the inflatable balloon. With this arrangement, the catheter does not kink or collapse due to the pressure exerted on the catheter wall when the balloon is inflated. In one embodiment, the reinforcing member includes an annular shaped ring. In another embodiment, the separator is positioned under the balloon and acts as the reinforcing member.

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Номер записи: 53
17-02-2022 дата публикации

Inhalable Formulation of Fluticasone Propionate and Albuterol Sulfate

Номер: US20220047610A1
Автор: Brian Paul O'NEILL, Chris David EDLIN, Hardik Kirtikumar Shah, Julian Alexander Blair, Shane Michael MCKEON
Принадлежит: Norton Waterford Ltd

This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an α-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.

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Номер записи: 54
31-01-2019 дата публикации

Compliance monitoring module for a breath-actuated inhaler

Номер: US20190030267A1
Автор: Daniel Buck, Douglas E. Weitzel, Enrique Calderon Oliveras, Mark Steven Morrison
Принадлежит: Norton Waterford Ltd

A compliance monitoring module for a breath-actuated inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being pneumatically coupled to a flow channel through which a user can inhale; a processor configured to: receive a signal originating from a dosing mechanism of the inhaler indicating that medication has been released; receive data from a sensing element of the sensor; and based on said signal from said dosing mechanism and said data from said sensing element, make a determination that inhalation of a breath containing medication through said flow channel complies with one or more predetermined requirements for successful dosing; and a transmitter configured to, responsive to said determination, issue a dosing report.

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Номер записи: 55
30-01-2020 дата публикации

LIQUID-GAS SEPARATOR

Номер: US20200030501A1
Автор: Minskoff Noah Mark
Принадлежит: CONMED CORPORATION

A method and system for separating a flow of matter is shown and described. The system includes one or more flow separation devices, one or more surgical instruments, and one or more suction sources. In some embodiments, the flow of matter comprises biological material. In some embodiments, the flow of matter comprises surgical waste. 1. A method of operating a separator comprising: a cylindrical cavity having a cylindrical wall and first cylindrical cavity end and a second cylindrical cavity end, configured to operate with the first cylindrical cavity end up;', 'a conical cavity having a narrow end and a wide end, the wide end mated to the second cylindrical cavity end;', 'an input port disposed in the cylindrical cavity wall configured to receive a flow of matter;', 'an suction port mated to the first cylindrical cavity end and configured to couple to a vacuum source;', 'a collection port mated to the narrow end of the conical cavity and configured to couple to a waste deposit;', 'a baffle disposed between the input port and the suction port, configured to prevent the flow of matter from passing directly from the input port to the suction port without first traversing at least a portion of a circumference of an interior of the cylindrical wall; and', 'a cylindrical shaft disposed within a center of the cylindrical cavity and configured to direct the flow of matter within the cylindrical cavity,, 'a separator body comprising, 'providing a separator comprisingattaching the suction port to the suction source;mating the collection port to a waste deposit;activating the suction source thereby creating the flow of matter into the input port;expelling portions of the flow of matter out of the collection port; andpulling portions of the flow of matter out of the suction port.2. The method of operating a separator of claim 1 , further comprising locating the input port off-axis of an axis defined by a longitudinal center of the separator body.3. The method of operating a ...

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Номер записи: 56
30-01-2020 дата публикации

ENHANCED EDUCTOR DESIGN

Номер: US20200030555A1
Автор: Kakade Prashant, Leonard John, Stedman Benjamin, Woehler Darrell
Принадлежит:

The present invention provides for an enhanced eductor element that significantly increases the amount of pressure generated at the siphon tube without significantly increasing the flow resistance through the eductor. The invention further provides for breath-actuated inhalation devices including the enhanced eductor element as an actuation mechanism. 1. An enhanced eductor element comprising:a conduit comprising an inner surface, an outer surface, an inlet, an outlet, and a hollow bore extending between the inlet and the outlet, the bore tapering in a constriction zone between the inlet and the outlet;a modification member in the constriction zone and protruding from the inner surface to locally reduce a cross-sectional area of the constriction zone; anda siphon channel providing fluid communication between a siphon inlet at the conduit outer surface and a siphon outlet at the conduit inner surface, the siphon outlet being positioned adjacent to the modification member;wherein the modification member is configured to increase a siphon pressure drop at the siphon inlet without a substantial increase in a pressure drop across the eductor element.2. The eductor element of claim 1 , wherein the modification member comprises a bump on the inner surface of the conduit in the constriction zone.3. The eductor element of claim 1 , wherein the modification member comprises a conical bump and the siphon channel extends to an apex of the conical bump.4. The eductor element of claim 1 , wherein at least a portion of the modification member is disposed intermediate the conduit inlet and the siphon outlet in the constriction zone.5. The eductor element of claim 1 , wherein the siphon channel extends through the modification member to the inner surface.6. The eductor element of claim 1 , wherein the constriction zone defines a first diameter claim 1 , the first diameter being constant throughout the constriction zone.7. The eductor element of claim 1 , wherein the constriction ...

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Номер записи: 57
30-01-2020 дата публикации

MEDICAL COMPONENTS WITH MICROSTRUCTURES FOR HUMIDIFICATION AND CONDENSATE MANAGEMENT

Номер: US20200030565A1
Автор: Hermez Laith Adeeb, Sims David John
Принадлежит:

New medical circuit components and methods for forming such components are disclosed. These components include microstructures for humidification and/or condensate management. The disclosed microstructures can be incorporated into a variety of components, including tubes (e.g., inspiratory breathing tubes and expiratory breathing tubes and other tubing between various elements of a breathing circuit, such as ventilators, humidifiers, filters, water traps, sample lines, connectors, gas analyzers, and the like), Y-connectors, catheter mounts, humidifiers, and patient interfaces (e.g., masks for covering the nose and face, nasal masks, cannulas, nasal pillows, etc.), floats, probes, and sensors in a variety of medical circuits. 180-. (canceled)81. A humidification chamber suitable for use with a humidifier , comprising:a humidification chamber body defining an interior space, the interior space configured to hold water;a mixing element within the humidification chamber body, the mixing element configured to facilitate mixing of gaseous and liquid phases of water.82. The humidification chamber of claim 81 , wherein the mixing element is movable in response to a flow of gas through the humidification chamber body.83. The humidification chamber of claim 81 , wherein the mixing element is integral with the humidification chamber body.84. The humidification chamber of claim 81 , wherein the mixing element is supported by the humidification chamber body.85. The humidification chamber of claim 81 , wherein the mixing element extends downwardly from an upper wall of the humidification chamber body.86. The humidification chamber of claim 81 , wherein the mixing element comprises microstructures.87. The humidification chamber of claim 81 , wherein the mixing element comprises a turbine comprising a plurality of turbine blades.88. The humidification chamber of claim 87 , wherein the turbine blades comprise microstructures.89. The humidification chamber of claim 87 , wherein a ...

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Номер записи: 58
09-02-2017 дата публикации

NICOTINE POWDER INHALER

Номер: US20170035107A1
Автор: ZINOVIK Ihar Nikolaevich, ZUBER Gerard
Принадлежит:

This disclosure relates to nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime. 1. A nicotine powder inhaler comprising:a body extending between a mouthpiece portion and a distal end portion;an airflow channel extending between the mouthpiece portion and a distal end portion;a nicotine powder receptacle comprising a dose of nicotine powder and disposed along the airflow channel;wherein the dose of nicotine powder can be inhaled into lungs of a user at an inhalation rate of less than about 5 L/min.2. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder receptacle is configured to receive a capsule containing nicotine powder.3. A nicotine powder inhaler according to claim 2 , further comprising opposing piercing elements configured to pierce the received capsule and fluidly connect the nicotine powder with the airflow channel.4. A nicotine powder inhaler according to claim 1 , wherein the airflow channel extends linearly along the body from the distal end portion to the mouthpiece portion.5. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder is a nicotine salt.6. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder is nicotine bitartrate claim 1 , nicotine salicylate claim 1 , nicotine fumarate claim 1 , nicotine mono-pyruvate claim 1 , or nicotine hydrochloride.7. A nicotine powder inhaler according to claim 1 , wherein at least about 90 wt % of the nicotine powder has a particle size of about 10 micrometers or less.8. A nicotine powder inhaler according to claim 1 , further comprising a swirl generator element configured to induce rotational movement in the airflow from the airflow channel.9. A nicotine powder inhaler according to claim 1 , further comprising a second airflow channel extending between the mouthpiece portion and a distal end portion and a second powder receptacle and disposed along the second airflow channel.10. A ...

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Номер записи: 59
09-02-2017 дата публикации

FLAVOURED NICOTINE POWDER INHALER

Номер: US20170035108A1
Автор: ZINOVIK Ihar Nikolaevich, ZUBER Gerard
Принадлежит:

This disclosure relates to flavoured nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime. 1. A nicotine powder inhaler comprising:a body extending between a mouthpiece portion and a distal end portion;an airflow channel extending between the mouthpiece portion and a distal end portion;a nicotine powder receptacle disposed along the airflow channel and comprising a dose of nicotine powder and;a flavour delivery element in fluid connection with the airflow channel;wherein the dose of nicotine powder can be inhaled into lungs of a user at an inhalation rate of less than about 5 L/min.2. A nicotine powder inhaler according to claim 1 , wherein the flavour delivery element is upstream of the nicotine powder receptacle.3. A nicotine powder inhaler according to claim 1 , wherein the flavour delivery element is downstream of the nicotine powder receptacle.4. A nicotine powder inhaler according to claim 1 , further comprising a second airflow channel comprising a flavour receptacle wherein the flavour receptacle is in parallel flow relation with the nicotine powder receptacle.5. A nicotine powder inhaler according to claim 1 , wherein the flavour element comprises powdered flavourant.6. A nicotine powder inhaler according to claim 1 , wherein the flavour element comprises liquid flavourant.7. A nicotine powder inhaler according to claim 1 , wherein the nicotine powder receptacle is configured to receive a capsule containing nicotine powder comprising nicotine salt.8. A nicotine powder inhaler according to claim 7 , wherein the capsule further contains the flavour delivery element comprising powdered flavourant.9. A nicotine powder inhaler according to claim 1 , wherein the flavour delivery element comprises a crushable capsule that can be ruptured by a user to release flavourant.10. A nicotine powder inhaler according to claim 1 , further comprising a filter element upstream of the nicotine powder receptacle and the ...

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Номер записи: 60
11-02-2016 дата публикации

Therapeutic Retrieval of Targets in Biological Fluids

Номер: US20160038668A1
Автор: MIZUKAMI Hiroshi, Ostafin Agnes
Принадлежит:

Method and apparatus for removing high density particles from a biological fluid such as blood using aphaeresis. The particles are preferably sub-micron in size and denser than normally occurring components of the fluid and can be removed by a modified reverse-flow gradient density centrifuge without damaging the fluid. The particles can be provided to a patient in vivo or added to the fluid after it is removed from the patient. Some particles can carry and deliver oxygen and scavenge carbon dioxide. Other particles are conjugated to capture molecules for attaching to targets such as cancer cells, viruses, pathogens, toxins, or excess concentrations of a drug or element in the fluid. The targets are then removed from the fluid along with the particles by the aphaeresis instrument. 1. An aphaeresis apparatus for removing high density nanoparticles functionalized with a capture molecule from a biological fluid that is flowing within the aphaeresis apparatus , the apparatus comprising:a laminar flow mixing device comprising a plurality (n) of tubes with each tube of the plurality of tubes having an inner diameter of a2 which is between about 1-5 mm and a length of l2 which is between about 0.001-24 m through which each tube of the plurality of tubes permits stable laminar flow of the biological fluid at a flow rate of f2 and wherein the total flow rate of the biological fluid through the laminar flow mixing device is f2×n which is about equal to the total flow rate of the biological fluid entering the laminar flow mixing device from a first tube;{'sub': 2', '1, 'the first tube having a diameter A1 through which the biological fluid flows at a flow rate F1 and wherein F1>f2 and wherein n×ais about equal to A;'}a second tube having an inner diameter A3 is in fluid communication with the plurality of tubes of the laminar flow mixing device past the outlet passes to a reverse-flow density gradient (RFDG) centrifuge having a rotor via the second tube wherein the flow rate ...

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Номер записи: 61
09-02-2017 дата публикации

Device for retaining humidity in a patient interface

Номер: US20170035978A1
Автор: Emma Anne CONNELL, Liam Holley
Принадлежит: ResMed Pty Ltd

A patient interface for sealed delivery of a flow of air to ameliorate sleep disordered breathing may include: a seal-forming structure to form a pneumatic seal with the entrance to the patient's airways; a positioning and stabilising structure to maintain the seal-forming structure in sealing contact with an area surrounding the entrance to the patient's airways; a plenum chamber pressurised at a pressure above ambient pressure in use; a connection port for the delivery of the flow of breathable gas into the patient interface; and a device positioned within a breathing chamber defined, at least in part, by the seal-forming structure and the plenum chamber, wherein the device divides the breathing chamber into a posterior chamber and an anterior chamber, and wherein the device comprises a plurality of apertures such that turbulence of the air in the posterior chamber is less than turbulence in the air in the anterior chamber.

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Номер записи: 62
09-02-2017 дата публикации

HUMIDIFIER TUB FOR CPAP DEVICE

Номер: US20170035984A1
Автор: BONILLA William, JONES Richard Llewelyn, SMITH Ian Malcolm
Принадлежит:

A humidifier includes a humidifier tub with an air inlet and an air outlet. An uppermost end of the air outlet terminates at an exit port positioned in a plane disposed below the air inlet. The air inlet is configured so that air enters the humidifier tub through the air inlet in a lateral direction. The humidifier also includes a base plate provided to a bottom of the humidifier tub. The base plate and humidifier tub define a water chamber adapted to receive a volume of liquid water. The humidifier tub further includes a guidance structure adapted to direct air entering the humidifier tub via the air inlet to swirl downwardly and around within the water chamber and into contact with the liquid water before exiting the exit port. 1. A humidifier comprising:a humidifier tub including an air inlet and an air outlet, an uppermost end of the air outlet terminating at an exit port positioned in a plane disposed below the air inlet, the air inlet being configured so that air enters the humidifier tub through the air inlet in a lateral direction; anda base plate provided to a bottom of the humidifier tub, the base plate and humidifier tub defining a water chamber adapted to receive a volume of liquid water,wherein the humidifier tub includes a guidance structure adapted to direct air entering the humidifier tub via the air inlet to swirl downwardly and around within the water chamber and into contact with the liquid water before exiting the exit port.2. The humidifier according to claim 1 , wherein the guidance structure includes a curved baffle located within the water chamber in front of the air inlet.3. The humidifier according to claim 1 , wherein the guidance structure includes a chamfered wall portion located within the water chamber in front of the air inlet.4. The humidifier according to claim 1 , wherein the base plate is constructed of a heat-conductive material.5. The humidifier according to claim 1 , wherein the base plate is constructed of aluminum.6. The ...

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Номер записи: 63
24-02-2022 дата публикации

Sanitizing steam room

Номер: US20220054690A1
Автор: Etgar Eisenstadt Michael, Wallach Alon
Принадлежит:

A steam room for sanitizing people's external body parts and clothes, but also their breathing airways and respiratory tract, to reduce viral load and thereby mitigate the likelihood of spreading or contracting Viral contamination. Steam room has precise temperature and relative humidity control of a heater and mist generator, in which the mist water molecules contain an accurate concentration of a Chlorine or Ethanol based disinfectant, so that the water vapor or combined air/water mixture in the room that comes in contact with the sanitized person reaches but does not surpass the globally permitted concentration of free Chlorine for swimming pools, dressing rooms and spas. The room has thermally isolated quick doors allowing rapid entry and exit, and the signaling to guide the person when to enter, stay and breath, and exit, in the most suitable timing profile for the application. 1) A sanitizing cabin misted with active disinfectant normally used for disinfecting swimming pools , to sanitize people , their external body parts and clothes , and their airways , comprising:a. Cabin or room with walls ceiling and at least one door.b. Reservoirs of water and disinfectant material.c. Misting said water and said disinfectant and entering them into said cabin in a precise and uniform concentration of active material of said disinfectant.d. Said cabin has displays that instruct said sanitized person to stay long enough inside said cabin and breath said uniform concentration of active disinfectant, for effectively sanitizing said person's airways.2) The Cabin as in wherein said mist is heated by a heat convector or at least one of the following: Infrared heater claim 1 , Ceramic heater claim 1 , heat radiator claim 1 , heating fan claim 1 , heating spiral.3) The Cabin as in wherein said cabin comprises walls built from isolated panels with 2 or more thin metal or plastic layers and a thicker layer of insulating air or airy material between said layers.4) The misted cabin ...

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Номер записи: 64
07-02-2019 дата публикации

FLUID FLOW REGULATION ARRANGEMENTS FOR DRUG DELIVERY DEVICES

Номер: US20190038835A1
Автор: "OCONNOR Jason", Allis Daniel, MCLAUGHLIN Ian, NAZZARO David
Принадлежит:

A fluid flow regulator of a fluid delivery system that can adjust a flow rate of a liquid drug dispensed from a liquid drug container to a user is provided. The fluid flow regulator can be coupled to an end of the liquid drug container. The fluid flow regulator can include a compliance plate and a flow channel selector plate having a fluid flow channel. The flow channel selector plate can be rotated relative to the compliance plate and the liquid drug container to expose a selected portion of the fluid flow channel to openings in the compliance plate that are in fluid communication with the liquid drug stored in the liquid drug container. The selected portion of the fluid flow channel can correspond to a corresponding flow resistance of the liquid drug through the fluid flow channel, thereby regulating the flow of the liquid drug to the user. 1. A fluid regulating arrangement for dispensing a liquid drug , comprising:a liquid drug container;a compliance plate coupled on a first side to a first end of the liquid drug container;a flow channel selector plate coupled to a second side of the compliance plate; anda needle coupled to a central opening of the flow channel selector plate;wherein the first end of the liquid drug container comprises first and second flow manifolds, the first flow manifold having a first end in fluid communication with an interior of the liquid drug container configured to store a liquid drug, and a second end in fluid communication with a first opening of the compliance plate;wherein the flow channel selector plate is rotatable with respect to the compliance plate and the liquid drug container, the flow channel selector plate further having a fluid flow channel for receiving the liquid drug from the liquid drug container through the first flow manifold and the first opening of the compliance plate, and for directing the liquid drug out through a second opening of the compliance plate;wherein the second opening of the compliance plate is in ...

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Номер записи: 65
06-02-2020 дата публикации

INTRAVENTRICULAR PULSATING BLOOD PUMP

Номер: US20200038570A1
Автор: DANG Weiguo, HUANG Penghui, XU Boling
Принадлежит:

The invention provides an intraventricular pulsating blood pump fixedly disposed at the ventricularapex inside the ventricle to generate pulsation action. The pulsating blood pump is substantially jellyfish-shaped and includes a bell-shaped pump body and a driving source, an opening of the bell-shaped pump body faces to the outlet of the ventricle, the driving source drives the bell-shaped pump body to contract or relax, and the contraction or relaxation of the bell-shaped pump body drives the blood in the ventricle to eject directionally to the artery and form a convoluted blood flow field between the inner wall of the bell-shaped pump body and the inner wall of the ventricle. The invention not only provides assist to ventricular by pulsating blood flow, but also optimizes the flow field and pressure distribution in the ventricle, the blood pump of the invention is better in biocompatibility than the blood pumps in prior art. 1. An intraventricular pulsating blood pump , which has an open pump body to generate pulsation action and is fixedly disposed at the ventricularapex inside the ventricle , wherein the intraventricular pulsating blood pump is generally jellyfish-shaped and includes:a bell-shaped pump body, an opening of the bell-shaped pump body facing to an outlet of the ventricle; anda driving source, which drives contraction and relaxation of the bell-shaped pump body to change the volume of an inner cavity of the bell-shaped pump body, when the volume of the inner cavity is reduced, the blood in the bell-shaped pump body is pressed outwards, thereby realizing blood ejection to the ventricle, and when the volume of the inner cavity is increased, the blood outside of the bell-shaped pump body is inhaled into the bell-shaped pump body to provide blood for a next blood ejection.2. The intraventricular pulsating blood pump according to claim 1 , wherein the contraction and relaxation of the bell-shaped pump body allows the blood to produce the Venturi effect ...

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Номер записи: 66
18-02-2021 дата публикации

Hydrodynamic vortex aspiration catheter

Номер: US20210045770A1
Автор: Albert Jau-Min SHIH, Jeffrey Stephen Plott, Luis Emilio SAVASTANO, Yang Liu, Yihao ZHENG
Принадлежит: University of Michigan

An actuated telescoping system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defining a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen. The telescoping system can be capable of reversibly transitioning between navigation and thrombectomy modes by differentially disposing and actuating the components and enable faster, more efficient and simpler removal of thromboembolic material.

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Номер записи: 67
18-02-2021 дата публикации

Flow enhancement for circulatory support device

Номер: US20210046231A1
Автор: Jan Weber, Matthew Boyer
Принадлежит: Boston Scientific Scimed Inc

An inlet tube of a circulatory support device includes a first end configured to receive incoming blood and a second end coupled to a first end of a blood pump. A lumen extends from the first end to the second end, and a spiral feature is disposed within the lumen and configured to support a spiral flow of the incoming blood.

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Номер записи: 68
18-02-2021 дата публикации

MAGNETIC FILTER APPARATUS AND METHOD

Номер: US20210046237A1
Автор: FRODSHAM George Charles Martin, Hattersley Simon Richard, Pankhurst Quentin Andrew, WENMAN Richard Alan
Принадлежит: MEDISIEVE LTD

A hemofilter system. In one embodiment, the hemofilter system includes a container having a first surface, a second surface, and one or more wall surfaces, the first surface, the second surface and the one or more wall surfaces defining a volume; an input port in fluid communication with the first surface; an output port in fluid communication with the second surface; a filter bed comprising a plurality of planar magnetic meshes stacked in close juxtaposition and positioned within the container volume and coplanar with the first and second surfaces; a first magnet positioned on a first surface of the container; a second magnet positioned on the second surface of the container; a first input conduit in fluid communication with the input port; and a first output conduit in fluid communication with the output port. In another embodiment, the hemofilter system includes a pump in the input conduit. 119-. (canceled)20. A magnetic retention hemofilter system comprising:a container having a first surface, a second surface, and one or more wall surfaces, the first surface, the second surface and the one or more wall surfaces defining a container volume;an input port in fluid communication with the container;an output port in fluid communication with the container;a filter bed comprising a plurality of planar magnetic meshes stacked with their mesh planes in close juxtaposition and positioned within the container volume;a first magnet positioned on a first surface of the container, the first surface substantially perpendicular to fluid flow through the container;a first input conduit in fluid communication with the input port;a first output conduit in fluid communication with the output port, wherein the first magnet produces a magnetic field that is oriented substantially perpendicular relative to the planes of the planar magnetic meshes and substantially parallel to fluid flow through the container.21. The hemofilter system of further comprising a pump in the input conduit. ...

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Номер записи: 69
18-02-2016 дата публикации

DOWNSTREAM FLOW DETECTION SYSTEM FOR FLOW CONTROL APPARATUS

Номер: US20160045400A1
Автор: Hudson Joseph
Принадлежит:

A flow control apparatus adapted to load a feeding set having an upstream side and a downstream side including a housing capable of receiving at least a portion of the feeding set. A pumping device contacts the feeding set when the feeding set is received by the housing so the pumping device acts on the feeding set to produce fluid flow in the feeding set for delivery of fluid to a subject. An ultrasonic sensor is arranged with respect to the pumping device to detect a change in pressure in the downstream side of the feeding set when the feeding set is loaded on the apparatus. 1. A flow control apparatus adapted to load a feeding set having an upstream side and a downstream side , said flow control apparatus comprising:a housing capable of receiving at least a portion of the feeding set;a pumping device contacting the feeding set when the feeding set is received by the housing so the pumping device acts on the feeding set to produce fluid flow in the feeding set for delivery of fluid to a subject; andan ultrasonic sensor arranged with respect to the pumping device to detect a change in pressure in the downstream side of the feeding set when the feeding set is loaded on the apparatus.2. The flow control apparatus set forth in wherein the ultrasonic sensor comprises a receiver assembly and an ultrasonic transmitter assembly claim 1 , the transmitter assembly being configured to transmit an ultrasonic signal through the downstream side of the feeding set to the receiver assembly for determining the downstream flow condition of the feeding set when the feeding set is loaded on the apparatus.3. The flow control apparatus set forth in claim 1 , further comprising a control circuit in communication with the ultrasonic sensor for receiving a sensor signal from the ultrasonic sensor indicative of the pressure in the downstream side of the feeding set claim 1 , the control circuit being configured to determine the downstream flow condition of the feeding set while fluid is ...

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Номер записи: 70
15-02-2018 дата публикации

TREATMENT OF ASTHMA, ALLERGIC RHINITIS AND IMPROVEMENT OF QUALITY OF SLEEP BY TEMPERATURE CONTROLLED LAMINAR AIRFLOW TREATMENT

Номер: US20180043128A1
Автор: Kornfeld Mark, Kristensson Dan Allan Robert, Svensson Pal Martin
Принадлежит: Airsonett AB

This invention relates in general to methods and devices for displacing body convection and thereby reducing exposure to allergens and other airborne fine particles within a personal breathing zone during situations of or corresponding to sleep thereby reducing or removing symptoms of asthma and allergic rhinitis while improving quality of sleep and in particular to methods and devices that utilize Temperature controlled Laminar Airflow (abbreviated TLA from herein and onwards). Also, business methods involving such methods and devices are disclosed. 12-. (canceled)3. A method of decreasing or suppressing the level of Immunoglobulin E (IgE) antibodies in a person comprisingcreating a breathing zone around the person's nose and mouth,delivering treated air into the breathing zone using a device which includes at least one of each of an air inlet, a filter, a blower, an air supply nozzle and a housing, wherein said device removes more than 95% of particles larger than 0.5 and which delivers said treated air by temperature controlled laminar air flow,detecting the temperature of said treated air by a first sensor situated such that it is in an air-stream of said treated air in said breathing zone,detecting the temperature of ambient air situated at a level of the person's personal breathing zone but outside the air-stream of said treated air by a second sensor,controlling the temperature of the temperature controlled laminar air flow in the breathing zone so that the air in the breathing zone is maintained at a temperature of 0.5 to 0.9° C. cooler than the ambient air situated at a level of the person's personal breathing zone but outside the air-stream, andcausing the temperature controlled laminar air flow to descend from the delivering device at a rate of less than 0.2 m/s and into the breathing zone at a rate higher than 0.1 m/s which displaces the body convection currents of the person and substantially avoids in-mixing of ambient surrounding air into the ...

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Номер записи: 71
03-03-2022 дата публикации

Ears Disimpactor

Номер: US20220062054A1
Автор: Merz Guy Francis
Принадлежит:

An ear disimpactor for disimpacting material impacted in an ear canal and against a tympanic membrane, is disclosed. The impacted material comprises cerumen, insects, and other debris. The ear disimpactor comprises a housing, a warm water irrigation unit, and a suction unit. The housing comprises an ear speculum attached to an outer surface of the housing, a motorized auger comprising a drill bit extending from the motorized auger to a tip of the ear speculum, a warm water line extending from the tip of the ear speculum and across a length of the housing, and a suspension suction tube extending from the tip of the speculum and across the length of the housing. The warm water irrigation unit provides warm water to the ear canal through the warm water line and the suction unit sucks out suspension from the ear canal.

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Номер записи: 72
25-02-2021 дата публикации

INHALER WITH COMPOSITE POROUS SUPPORT ELEMENT

Номер: US20210052832A1
Автор: "DAMBRA Gianpaolo", Capo Silvia, Spadaro Fabiana
Принадлежит:

An inhaler article includes a body () extending along a longitudinal axis from a mouthpiece () end to a distal end with an endpiece element at the distal end (). A capsule cavity is defined within the body. An air inlet region is between the endpiece element () and the capsule cavity (). A composite porous support element () defines a downstream end of the capsule cavity. The composite porous support element is formed of a first porous material concentrically disposed about a second porous material. The first porous material has a first resistance to draw and the second porous material having a second resistance to draw. The first resistance to draw is different than the second resistance to draw. A mouthpiece air channel () extends from the capsule cavity, through the composite porous element to the mouthpiece end. 1. An inhaler article comprising:a body extending along a longitudinal axis from a mouthpiece end to a distal end;an endpiece element at the distal end;a capsule cavity defined within the body and extending along the longitudinal axis a cavity length;an air inlet region between the endpiece element and the capsule cavity, the air inlet region having an air inlet and an air passageway extending from the air inlet to the capsule cavity;a composite porous support element defining a downstream end of the capsule cavity, the composite porous support element formed of a first porous material concentrically disposed about a second porous material, the composite porous support element extending along a longitudinal axis a length, the first porous material having a first resistance to draw and the second porous material having a second resistance to draw, the first resistance to draw being different than the second resistance to draw, the second porous material forms a central core portion and the first porous material forms an outer periphery layer circumscribed about the central core portion, the central core portion forms a cylinder, and the outer periphery ...

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Номер записи: 73
13-02-2020 дата публикации

ERGONOMIC AND ADJUSTABLE RESPIRATORY MASK ASSEMBLY WITH ELBOW ASSEMBLY

Номер: US20200046930A1
Автор: GING Anthony Michael, MOORE Rachael Elizabeth, NASR Saad, PRICE Andrew Martin
Принадлежит:

A respiratory mask assembly for delivering breathable gas to a patient includes a frame having a front surface and a rear surface adapted in use to face the patient. The frame includes a main body providing an aperture therethrough for the introduction of breathable gas into a nasal breathing cavity. An elbow assembly is swivelably coupled to the front surface of the frame. The elbow assembly includes a swivel elbow that defines an intake port and an exhaust port separated from the intake port using a baffle. The elbow assembly includes an end portion that interfaces with the aperture of the frame. 1. A respiratory mask assembly for delivering breathable gas to a patient , comprising:a frame having a front surface and a rear surface adapted in use to face the patient, the frame including a main body providing an aperture therethrough for the introduction of breathable gas into a nasal breathing cavity; andan elbow assembly swivelably coupled to the front surface of the frame, the elbow assembly including a swivel elbow that defines an intake port and an exhaust port separated from the intake port using a baffle,wherein the elbow assembly includes an end portion that interfaces with the aperture of the frame.2. A respiratory mask assembly according to claim 1 , wherein the elbow assembly has a surface that is adapted to directly engage a surface of a gas delivery tube.3. A respiratory mask assembly according to claim 1 , wherein the elbow assembly is adapted to be connected directly to the gas delivery tube without a swivel connector between the elbow assembly and the gas delivery tube.4. A respiratory mask assembly according to claim 1 , wherein the elbow assembly includes a mating portion that is inserted into the aperture provided in the frame and a lock is attached to the mating portion from an inner side of the frame so as to prevent withdrawal of the mating portion from the aperture.5. A respiratory mask assembly according to claim 1 , wherein the baffle is ...

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Номер записи: 74
15-05-2014 дата публикации

Flexible stretch hose having inwardly extending web portions connecting adjacent pairs of reinforcing coils, with hose properties enhanced by annealing

Номер: US20140130931A1
Автор: Martin E. FORRESTER
Принадлежит: SCHAUENBURG HOSE Tech GmbH

A flexible, stretchable, crush resistant hose particularly well suited for supplying breathing gases to patients in medical applications and the like has a helix defined by reinforcing coils of thermoplastic material, and a web of thermoplastic material bonded or welded to adjacent ones of the coils, preferably near outer diameter portions of the coils. The web extends radially inwardly between the adjacent pairs of the reinforcing coils to define a helical reverse-direction crease that can be located closer to or farther from a centerline of the hose than is the inner diameter of the reinforcing coils. The thermoplastic material of the hose is stress relieved by an annealing process performed during axial compression of the hose at a time after the hose has been formed.

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Номер записи: 75
10-03-2022 дата публикации

HUMIDIFICATION ARRANGEMENT FOR A RESPIRATORY APPARATUS

Номер: US20220072260A1
Автор: DARKIN Donald, Klasek Paul Jan, ROW Nathan John, VIRR Alexander
Принадлежит:

An air delivery tube for a CPAP system includes a first end configured to connect to a flow generator of the CPAP system and a second end configured to connect to a patient interface of the CPAP system. The air delivery tube also includes a central lumen that is formed by an inner wall of the air delivery tube and is configured to convey pressurized breathable gas from the first end to the second end. In addition, a circumferential chamber surrounds the central lumen and is configured to retain a supply of water. A wick is located within the central lumen and is connected to the inner wall. 1. A gas conduit for respiratory apparatus , including a lumen for passage of a breathable gas to a patient and a flexible conduit wall surrounding the lumen , the flexible conduit wall having a humidification apparatus for delivering water vapour into the gas passing through the lumen.2. A gas conduit according to claim 1 , wherein said humidification apparatus comprises one or more liquid water delivery passages extending along the conduit wall and means for vaporising said liquid water to produce said water vapour.3. A gas conduit according to claim 2 , wherein said one or more water delivery passages extend helically along said conduit wall.4. A gas conduit according to claim 2 , wherein said one or more water delivery passages extend longitudinally along said conduit wall.5. A gas conduit according to claim 1 , wherein the humidification apparatus includes a heater for heating the water to form water vapour.6. A gas conduit according to where the heater is in thermal contact with the humidification apparatus such that the heater heats the water within the humidification apparatus.7. A gas conduit according to wherein said heater is in thermal contact with the gas passing through lumen.8. A gas conduit according to claim 7 , comprising a plurality of humidification apparatus and/or a plurality of heaters adapted for independent actuation.9. A gas conduit according to claim 1 ...

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Номер записи: 76
01-03-2018 дата публикации

MULTIPLE LUMEN HEAT EXCHANGE CATHETERS

Номер: US20180055687A1
Автор: KELLER Wade A., Machold Timothy R.
Принадлежит:

Catheter devices and methods for intravascular heating and/or cooling of human or veterinary patients. The catheter devices generally comprise catheters having inflow and outflow lumens and at least one curvilinear balloon connected to the inflow and outflow lumens such that heat exchange fluid may be circulated through the balloon(s). The catheter is inserted into the vasculature and heated or cooled fluid is circulated through the balloon(s) to heat or cool blood flowing in heat-exchange proximity to the balloon(s), thereby effecting heating or cooling of all or a portion of the patient's body. 1. A method for controlling the temperature of at least a portion of the body of a human or animal subject , said method comprising the steps of: the heat exchange catheter comprises an elongate, flexible catheter having an inflow lumen and an outflow lumen and at least one heat exchanger having first and second ends, the inflow lumen of the catheter being connected to the first end of the heat exchanger and the outflow lumen being connected to second end of the heat exchanger such that heat exchange fluid may be circulated into the first end of the heat exchanger, through the heat exchanger and out of the second end of the heat exchanger; and', 'the controller receives i) a target temperature input and ii) a sensed subject body temperature input and causes heated or cooled fluid to circulate into the first end of the heat exchanger, through the heat exchanger and out of the second end of the heat exchanger, to warm or cool the sensed subject body temperature as needed to cause the sensed subject body temperature to be approximately the same as the target temperature;, 'A) obtaining a heat exchange catheter system that comprises a heat exchange catheter and a controller, whereinB) inserting the heat exchange catheter into the vasculature of the patent and positioning the heat exchanger within a blood vessel through which blood is flowing such that the heated or cooled fluid ...

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Номер записи: 77
02-03-2017 дата публикации

MASK WITH GUSSET

Номер: US20170056611A1
Автор: Drew Joanne Elizabeth, Frater Robert Henry, Gunaratnam Michael Kassipillai
Принадлежит:

A mask system for delivering air to a user includes a suspension mechanism to allow relative movement between a face-contacting cushion and a mask shell. The suspension mechanism also provides a predetermined force to the cushion that is a function of mask pressure, displacement of the cushion or both. 1. A breathable gas mask arrangement , comprising:a mask shell having a portion adapted to receive a supply of pressurized breathable gas and a user side;a gusset portion having a first side attached to the user side of the shell and having a second side;a cushion having a first portion constructed and arranged to attach to the second side of the gusset portion and a second portion constructed and arranged to contact a user's face in use and provide a seal between the mask arrangement and the user's face; anda headgear constructed and arranged to attach the mask shell to the user;{'sub': g', 'c', 'g', 'c', 'g', 'c, "wherein, the gusset portion is constructed and arranged such that it can expand and contract to alter a distance between the mask shell and the cushion, an interior of the gusset portion being exposed to the supply of pressurized breathable gas and having a projected area on the user's face Awhich is greater than an area Aof contact of the cushion with the user's face such that the supply of pressurized breathable gas acting on the area Aprovides a component of a contact force Fof the cushion on the user's face, and a ratio of A/Ais at least 1.30."}2. A breathable gas mask arrangement as in claim 1 , wherein the ratio of A/Ais in a range of 1.50 to 5.00.3. A breathable gas mask arrangement as in claim 2 , wherein the ratio of A/Ais in a range of 2.00 to 4.00.4. A breathable gas mask arrangement as in claim 3 , wherein the ratio of A/Ais in a range of 2.25 to 3.50.5. A breathable gas mask arrangement as in claim 1 , wherein the gusset portion can expand and contract to alter the distance between the mask shell and the cushion by at least 15 mm.6. A ...

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Номер записи: 78
20-02-2020 дата публикации

CANNULA, ECMO ASSISTANCE SYSTEM

Номер: US20200054817A1
Автор: MORDANT Pierre
Принадлежит:

A cannula for the circulation of a fluid in an artery, includes a main lumen conveying a volume of fluid towards a first distal end; an accessory lumen including at least one inner portion arranged inside the main lumen, including: a proximal end situated downstream from the proximal end of the main lumen so as to capture a fraction of the flow of fluid entering the main lumen; a bent portion modifying the direction of flow of the fluid flow captured by the accessory lumen with respect to the direction of flow of the fluid emerging from the first end; a second distal end situated upstream from the first distal end of the main lumen, emerging on a side opening of the cannula so as to direct the captured fraction of liquid in the modified direction of flow. 1. A cannula for circulation of a fluid in an artery , comprising:a main lumen, conveying a volume of fluid to a first distal end; a proximal end located downstream from a proximal end of the main lumen, so as to divert a fraction of an incoming flow rate of the fluid in the main lumen;', 'an elbow portion modifying the direction of flow of the flow rate of fluid diverted by the secondary lumen relative to a direction of flow of the fluid emerging from the first end;', 'a second distal end upstream from the first distal end of the main lumen, flowing out through a lateral aperture of the cannula, so as to direct the diverted fraction of the liquid in the modified flow direction, where the second distal end corresponds to the lateral aperture., 'a secondary lumen, containing at least one inner portion positioned inside the main lumen, and partly extending parallel to the latter over a portion of the length of the main lumen, where the secondary lumen includes2. The cannula according to claim 1 , wherein the elbow portion guides the flow diverted by the secondary lumen in a direction roughly opposite the flow flowing to the end of the main lumen.3. The cannula according to claim 1 , wherein the secondary lumen is ...

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Номер записи: 79
20-02-2020 дата публикации

Processes For Delivery Of Viscous Drug Therapies

Номер: US20200054831A1
Автор: Blum Timothy M., Clay John D., Ellis Jeffrey L., Heintz Amy M., Risser Steven M., Scribben Eric C.
Принадлежит:

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein. 1. An injection device for delivering a high-viscosity fluid to a patient , comprising:a barrel having an interior space formed by a sidewall for containing at least a high-viscosity fluid to be dispensed by the injection device, a plunger end, and an open end, the open end including a nozzle having a constriction point and an orifice;wherein the interior space of the barrel includes an inner concentric wall positioned within the sidewall, wherein the inner concentric wall defines an inner compartment having the high-viscosity fluid and an outer compartment having a low-viscosity fluid within the barrel, and wherein the inner concentric wall has one or more openings permitting fluid communication between the compartments;a plunger movably operable within at least one compartment of the barrel;wherein the plunger is adapted to provide a depressing force substantially concurrently to the high-viscosity fluid within the inner compartment and the low-viscosity fluid within the outer compartment, thereby producing an annulus of the low-viscosity fluid around a core of the high-viscosity fluid as the fluids are dispensed from the orifice.2. The injection device of claim 1 , wherein a ratio of the viscosity of the high-viscosity fluid to the viscosity of the low-viscosity fluid is from about 60 to about 200.34-. (canceled)5. The injection device of claim 1 , further comprising a means for sealing located at the constriction point which ...

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Номер записи: 80
20-02-2020 дата публикации

Nasal Delivery Device and Methods of Use

Номер: US20200054843A1
Автор: LEVIN Bruce H.
Принадлежит:

The present invention relates to a medical device for intranasal delivery of a medicament. The medicament may be any type of medicament suitable for nasal administration and delivery in the form of a spray. The present invention ensures that a complete dosage of the medicament is delivered, especially to specific areas in the nasal cavity, such as the rear of the nasal cavity where the SPG is located. 1. A drug delivery system comprising: a housing configured to contain a medicament;a nozzle;a drug delivery mechanism to expel medicament from said nozzle;said nozzle having a bore and configured to direct the medicament to a predetermined area in the nasal passageway;said nozzle is in a retracted position prior to insertion into the nasal passageway; andwhen inserted into the nasal passageway said nozzle increases in length and extends into an extended position for delivery of the medicament.2. The drug delivery system of wherein said nozzle has a first surface area when in said retracted position and said nozzle has a second surface area when in said extended position; andsaid first surface area is less than said second surface area.3. The drug delivery system of wherein said nozzle creates a vortex of spray or a preconfigured plume.4. The drug delivery system of wherein said plume is circular.5. The drug delivery system of wherein said drug delivery mechanism is configured to have an adjustable pressure and said nozzle has an adjustable opening.6. The drug delivery system of wherein said drug delivery mechanism is a pump.7. The drug delivery system of wherein said nozzle contains one or more fins claim 2 , spirals claim 2 , helical elongated members claim 2 , rifling or grooves in the bore of the nozzle.8. The drug delivery system of wherein said nozzle contains solid structures in the bore to alter the flow.9. The drug delivery system of wherein said solid structures are conical claim 8 , spiral claim 8 , nautilus claim 8 , rain droplet shaped claim 8 , hi-conical ...

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Номер записи: 81
22-05-2014 дата публикации

Delivery devices

Номер: US20140137865A1
Автор: Douglas Ivan Jennings, Philip Seeney
Принадлежит: PHARMAXIS LTD

A delivery device is provided which comprises a container containing a dose of a powder and having at least one exit orifice for dispensing the dose from the container and a chamber adapted to receive the container in an operative configuration. The device further comprises at least one gas inlet by which gas may enter the chamber and at least one gas outlet by which gas and entrained powder may exit the chamber. The delivery device is operable to generate a gas flow through the chamber between the at least one gas inlet and the at least one gas outlet, which brings about orbital motion of the container within the chamber in that at least a central region of the container orbits a central axis of the chamber. The volume occupied by the container is at least 25% of the volume of the chamber.

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Номер записи: 82
28-02-2019 дата публикации

BLOOD RESERVOIR WITH BLOOD-HANDLING ASSEMBLY

Номер: US20190060550A1
Автор: Benatti Francesco, Pandolfini Clara, Silvestri Claudio
Принадлежит:

An apparatus includes a blood-flow-management assembly shaped to define a cylindrical aperture. The blood-flow-management assembly includes a blood collector having drainage holes configured to direct blood to a guide surface positioned below the blood collector. The guide surface may further include ribs that manage blood flow along the guide surface. 121-. (canceled)22. A blood reservoir comprising:a housing having a venous inlet and a vent inlet;a venous tube in fluid communication with the venous inlet;at least one vent tube in fluid communication with the vent inlet for directing blood to a blood-handling assembly that surrounds a portion of the venous tube; andthe blood-handling assembly positioned within the housing and including a blood-collection chamber defining drainage holes for directing blood to a guide surface.23. The blood reservoir of claim 22 , wherein the guide surface includes ribs protruding from the guide surface and configured to manage blood flow along the guide surface.24. The blood reservoir of claim 23 , wherein at least one of the ribs includes a top section and two legs extending from the top section in a downward direction.25. The blood reservoir of claim 22 , wherein the blood-handling assembly is shaped to define a cylindrical aperture that surrounds at least a portion of the venous tube.26. The blood reservoir of claim 22 , wherein the drainage holes are sized to prevent foam from entering an area of the blood reservoir below the blood-collection chamber.27. The blood reservoir of claim 22 , wherein the drainage holes form a circular array in the blood-collection chamber.28. The blood reservoir of claim 22 , further comprising:a defoamer surrounding the blood-collection chamber.29. The blood reservoir of claim 28 , wherein the blood-handling assembly is dimensioned to allow contact of blood with the defoamer only when blood foam is present in a filter assembly.30. The blood reservoir of claim 22 , wherein the blood-collection chamber ...

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Номер записи: 83
28-02-2019 дата публикации

DEVICE AND METHOD FOR INFUSING AND ASPIRATING FLUID

Номер: US20190060564A1
Автор: Hien Anthony, Maguire Shannon
Принадлежит: ANGIODYNAMICS, INC.

The instant invention discloses a low-profile infusion set for the infusion and aspiration of fluid. The infusion set comprises an infusion tubing, an extension tube, a housing, a needle, and a needle holder. The extension tube and needle are connected to the housing, creating improved fluid pressure rates and flow rates. 1. A device comprising:a needle comprising a needle proximal end, and a needle distal end;an extension tube comprising an extension tube proximal end and an extension tube distal end; and a reservoir having a cylindrical shape;', 'a first channel in fluid communication with the extension tube distal end; and', 'a second channel in fluid communication with the needle proximal end., 'a housing comprising2. The device of claim 1 , wherein the first channel is located along a tangent to the reservoir.3. The device of claim 1 , wherein the second channel is located along a tangent to the reservoir.4. The device of claim 1 , wherein the housing further comprises a protrusion.5. The device of claim 4 , wherein the protrusion comprises a first protrusion segment and a second protrusion segment.6. The device of claim 5 , wherein the first protrusion segment is formed from a section of a wall of the reservoir.7. The device of claim 5 , wherein the protrusion extends towards a first channel longitudinal axis.8. The device of claim 5 , wherein the second protrusion segment is formed from a section of a wall of the first channel.9. The device of claim 1 , wherein the cylindrical shape of the reservoir is configured to provide a circumferential fluid flow.10. The device of claim 1 , wherein the reservoir of the housing is toroidal in shape.11. The device of claim 1 , wherein the reservoir of the housing is spherical in shape.12. A method comprising the steps of: a needle comprising a needle proximal end, and a needle distal end;', 'an extension tube comprising an extension tube proximal end and an extension tube distal end; and', a reservoir having a cylindrical ...

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Номер записи: 84
28-02-2019 дата публикации

Heating arrangements for humidification systems

Номер: US20190060600A1
Автор: ALAMI Nordyn, Miller Jeremy Livingston, Partington Andrew John
Принадлежит:

An electrically conductive plastic (ECP) material can be used to heat water in a reservoir of a respiratory humidifier to encourage heating and/or humidification of gases passing through the respiratory humidifier. The electrically conductive plastic material can at least in part overmould the base and/or walls of the chamber and/or the reservoir of the respiratory humidifier. The reservoir can also partially or fully be formed from the electrically conductive plastic material. Furthermore, the humidification system can be configured to create substantially equal or differential heating of water in the reservoir. 115-. (canceled)16. A humidifier comprising:a reservoir; andan electrically conducting plastic (ECP) structure for heating liquid in the reservoir,wherein the ECP structure is constructed at least in part from a first section comprising an ECP material and a second section comprising one or more other materials.17. The humidifier of claim 16 , further comprising a chamber for receiving the reservoir.18. The humidifier of claim 17 , wherein the ECP structure is located in or forms part of the chamber.19. The humidifier of claim 16 , wherein the second section does not comprise an ECP material.20. The humidifier of claim 16 , wherein the ECP structure is molded such that the second section is integrally formed with the first section.21. The humidifier of claim 16 , wherein the ECP structure is constructed at least in part from alternating sections of an ECP material and one or more other materials.22. The humidifier of claim 16 , wherein at least one of the one or more other materials comprise a non-thermally conductive and/or non-electrically conductive material.23. The humidifier of claim 16 , wherein at least one of the one or more other materials comprise a metal or a ceramic.24. The humidifier of claim 16 , wherein the second section comprises an electrical structure.25. The humidifier of claim 24 , wherein the electrical structure comprises a metal ...

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Номер записи: 85
28-02-2019 дата публикации

METHOD FOR INFUSING STEM CELLS

Номер: US20190060611A1
Автор: Dib Nabil, Kohler Robert Edward
Принадлежит:

A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid. 1. A method for infusing a liquid into the vasculature of a patient which comprises the steps of:supplying a source of the liquid;providing an infusion catheter, wherein the infusion catheter has a proximal end and a distal end and is formed with a multi-lumen infusion unit mounted adjacent the distal end of the infusion catheter, and wherein the infusion catheter includes an inflation balloon affixed to the catheter proximal to the multi-lumen infusion unit;positioning the distal end of the infusion catheter in an artery of the vasculature of the patient at a location within a predetermined distance from an intended target tissue surface;inflating the inflation balloon to at least partially occlude the artery; andexerting a force on the liquid to establish a flow rate for the liquid in the catheter to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue, wherein the flow rate is established in accordance with an infusion protocol, and ...

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Номер записи: 86
17-03-2022 дата публикации

Device and method for the dynamically sealing occlusion or space-filling tamponade of a hollow organ

Номер: US20220080141A1
Автор: Fred Göbel
Принадлежит: Creative Balloons Maschinenbau GmbH and Co KG

The invention refers to a device and a method for the dynamically sealing intubation of a hollow organ, comprising or using a tube in the form of a shaft that can be inserted into the hollow organ, with a primary lumen to provide access through or to the hollow organ in question, and comprising an intracorporeal sealing balloon, which surrounds a distal region of the shaft of said tube in the manner of a cuff for the purpose of sealing it against the hollow organ, wherein one or more secondary lumens for filling said intracorporeal sealing balloon are integrated into the wall of at least a proximal region of said shaft, wherein, within each cross-sectional plane that is intersected perpendicularly by the local longitudinal direction of the device, the following applies for the overall interior cross-section Q1 of the primary lumen and the sum Q2 of the interior cross-sections of all secondary lumens:Q2/(Q1+Q2)≥0.06,wherein at an extracorporeal filling tube, which communicates with all secondary lumens, a control device is provided in order to keep the pressure within the intracorporeal sealing balloon nearly constant in such a way thata) when the volume of the hollow organ increases, a corresponding amount of the filling medium is forced to flow into the intracorporeal sealing tube in order to increase the volume of the intracorporeal sealing tube accordingly, andb) when the volume of the hollow organ decreases, a corresponding amount of the filling medium is allowed to flow out of the intracorporeal sealing tube in order to decrease the volume of the intracorporeal sealing tube accordingly.

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Номер записи: 87
10-03-2016 дата публикации

METHODS AND APPARATUS FOR DELIVERING AEROSOLIZED MEDICATION

Номер: US20160067429A1
Автор: Kakade Prashant
Принадлежит:

A pulmonary drug delivery device having one or more vortexing elements which impart beneficial flow characteristics to an inspiratory air flow carrying a medicament into the patient's lungs. 1. An aerosol flow control apparatus for use in a pressurized metered dose inhaler , said apparatus comprising:(a) a housing defining a conduit, said conduit having an open end that provides a mouthpiece, a substantially closed end, and a vortexing back plate positioned remotely from the open end and defining the substantially closed end; said vortexing back plate comprising a first set of vortexing air inlets in fluid communication with ambient air outside the conduit;wherein said vortexing back plate is disposed in the conduit such that the first set of vortexing air inlets opens into a direction towards the mouthpiece; andwherein said first set of vortexing air inlets is angled so as to impart a vortexing motion to the ambient air drawn into the conduit through the first set of vortexing air inlets; and(b) a pressurized canister comprising a medicament, said pressurized canister arranged within the housing to direct a bolus of the medicament into the conduit.2. The aerosol flow apparatus of claim 1 , further comprising a second set of vortexing air inlets disposed about the periphery of the vortexing back plate.3. The aerosol flow apparatus of or claim 1 , wherein the vortexing air inlets comprise inwardly directed vanes which are oriented at an angle.4. The aerosol flow apparatus of claim 2 , wherein the second set of vortexing air inlets are triangular in shape so as to impart a further vortexing motion to the air drawn into the conduit through the first set of vortexing air inlets.5. The aerosol flow apparatus of claim 1 , wherein the votexing back plate is located behind the position at which the medicament bolus is introduced into an inspiratory air flow.6. The aerosol flow apparatus of or claim 1 , wherein the vortexing air inlets impart a tangential velocity to an ...

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Номер записи: 88
27-02-2020 дата публикации

VENTILATION DEVICE

Номер: US20200061327A1
Автор: FELDHAHN Karl Andreas, Gardein Joachim, GOEBEL Christof, Hein Stefan, Herrmann Frank, KLUIN Christian, PULLA Matthias, RESS Thomas, WEDLER Wolfgang
Принадлежит:

A ventilator with integrated breathing air humidifier has at least two defined air pathways provided in the breathing air humidifier. The breathing air humidifier is installed and fixed on a horizontal surface of the ventilator. The breathing air humidifier comprises at least a top part and a bottom part, a water reservoir being provided in the bottom part, wherein the top part cannot be removed from the bottom part when the unit is in at least one operating mode. The ventilator may have an air humidifier with at least one water reservoir, and at least one filling device for the water reservoir in the breathing air humidifier, wherein the filing device can be operated with one hand and/or opened with one hand. 1. A ventilator with an integratable breathing air humidifier , wherein the ventilator comprises at least two defined air pathways provided in a region of the breathing air humidifier , and further comprises at least one blower that is mounted in the ventilator by elastomeric elements.2. The ventilator with integratable breathing air humidifier according to claim 1 , wherein the breathing air humidifier comprises at least a top part and a bottom part claim 1 , a water reservoir being provided in the bottom part claim 1 , and wherein the top part cannot be removed from the bottom part when the ventilator is in at least one operating mode.3. The ventilator with integratable breathing air humidifier according to claim 1 , wherein in a housing of the ventilator a receptacle is provided into which at least a part of the air humidifier can be inserted and which comprises at least one connecting element for a functional connection of the air humidifier to the ventilator.4. The ventilator with integratable breathing air humidifier according to claim 2 , wherein in a housing of the ventilator a receptacle is provided into which at least a part of the air humidifier can be inserted and which comprises at least one connecting element for a functional connection of the ...

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Номер записи: 89
08-03-2018 дата публикации

VENTILATOR AEROSOL DELIVERY SYSTEM WITH TRANSITION ADAPTER FOR INTRODUCING CARRIER GAS

Номер: US20180064889A1
Автор: Gregory Timothy J., Henderson Christopher, Leamon James, Mazela Jan
Принадлежит:

A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for receiving carrier gas from a ventilator, which is in communication with a plurality of gas entry ports within the transition adapter. An inner cavity of the transition adapter receives the aerosol from the heated capillary and the streams of carrier gas from the plurality of gas exit ports within the transition adapter and directs the streams of carrier gas at least partially encircling and in parallel with the aerosol. An exit port on the distal end of the transition adapter housing delivers an entrained aerosol to an aerosol delivery connector. 1. An aerosol transition adapter for delivering an aerosolized active agent to a patient , the aerosol transition adapter comprising:a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a source of aerosol comprising an aerosolized active agent and the distal end having an exit port, the housing having a length between the distal end and the proximal end;a carrier gas connection port for receiving a carrier gas from a gas source, which is in communication with a plurality of carrier gas exit ports, the plurality of carrier gas exit ports are arranged adjacent to the aerosol passage in a pattern that partially encircles the flow of aerosol;an inner cavity, which is adapted to receive the aerosol from the aerosol passage and the carrier gas from the plurality of carrier gas exit ports and to direct streams of carrier gas to at least partially encircle and flow in parallel with a main direction of a flow of the aerosol along the length of the housing toward the exit port; andthe exit port on the distal end of the housing for delivering the aerosol to a ...

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Номер записи: 90
08-03-2018 дата публикации

INHALATION THERAPY DEVICE COMPRISING AN AMPOULE FOR STORING A MEDICAMENT TO BE NEBULIZED

Номер: US20180064891A1
Автор: Gallem Thomas, Hetzer Uwe
Принадлежит: PARI Pharma GmbH

An inhalation therapy device includes an atomizer for atomizing a drug which is advantageously present in the form of a fluid into an atomization chamber so that an aerosol or mist is provided in the atomization chamber. The patient or user can inhale the aerosol produced by the atomizer from the atomization chamber via a mouthpiece. The ampoule is inserted into an ampoule holder holding the fluid-containing ampoule. The inhalation therapy device also includes an opening unit for opening the fluid-containing ampoule. The ampoule holder advantageously includes a first part, disposed displaceably in relation to the opening unit, thereby allowing an ampoule present in the ampoule holder to be displaced in the direction of the opening unit. 1. Inhalation therapy device comprising:a body having a nebuliser device, a nebuliser chamber into which a fluid is to be nebulised by the nebuliser device, and an opening means;a lid,an ampoule holder disposed in the lid for retaining an ampoule containing the fluid to be nebulised and to be opened by the opening means,wherein the ampoule is moved in a direction of the opening means and is opened by the opening means in response to closing of the lid on the body, such that the opening means opens the ampoule disposed in the ampoule holder so that the fluid contained in the ampoule reaches the nebuliser device and wherein the opening means has a conduit through which the fluid from the ampoule reaches the nebuliser device.2. Inhalation therapy device according to claim 1 , wherein the opening means and the ampoule holder are displaceable in relation to one another along a substantially straight path.3. Inhalation therapy device according to claim 1 , wherein the opening means and the ampoule holder are displaceable in relation to one another along a substantially circular or helical path.4. Inhalation therapy device according to claim 1 , wherein the lid is closed by use of a screw thread.5. Inhalation therapy device according to ...

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Номер записи: 91
08-03-2018 дата публикации

NASAL CANNULA

Номер: US20180064898A1
Автор: Assi Milanjot Singh, Barraclough Michael, Cheung Dexter Chi Lun, Evans Alicia Jerram Hunter, Gulliver Laurence, Oldfield Samantha Dale, Payton Matthew Jon, SCHEIRLINCK Erik Robertus, Spence Callum James Thomas, White Craig Karl
Принадлежит:

The disclosure relates to a nasal cannula comprising a port configured for delivery of a medicament into a flow of a fluid being delivered by the nasal cannula to a user and/or configured for interfacing with a medicament delivery device or an instrument. The disclosure also relates to a nasal cannula comprising an asymmetric profile to reduce an amount of occlusion of one nare of a user to provide access for an instrument to the nare with the nasal cannula in use. 1. A nasal cannula comprising a port configured for delivery of a medicament into a flow of a fluid being delivered by the nasal cannula to a user and/or configured for interfacing with a medicament delivery device or an instrument.2. The nasal cannula as claimed in claim 2 , wherein the port comprises a guide for directing a flow of medicament into the flow of fluid claim 2 , or for directing the medicament delivery device or the instrument into the nasal cannula and/or the user's airway.3. The nasal cannula as claimed in claim 2 , wherein the guide provides for a pre-determined geometry of the port to direct claim 2 , locate or position the medicament delivery device or instrument or an outlet of the medicament delivery device or instrument at a desired angle or orientation relative to the nasal cannula.4. The nasal cannula as claimed in or claim 2 , wherein the guide is configured to provide a clearance between the guide and the medicament delivery device or the instrument.5. The nasal cannula as claimed in any one of to claim 2 , comprising at least one nasal prong or a pair of nasal prongs.6. The nasal cannula as claimed in any one of to claim 2 , wherein the port is located upon a nasal prong of the nasal cannula claim 2 , or wherein the interface comprises two ports claim 2 , each port located upon each of a pair of nasal prongs.7. The nasal cannula as claimed in any one of to claim 2 , wherein the port is located on a manifold part of the nasal cannula.8. The nasal cannula as claimed in claim 7 , ...

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Номер записи: 92
09-03-2017 дата публикации

Allergen Exposure System Comprising a Chamber for Mixing Air and Allergens, Which is Separated from the Exposure room That Accommodates the Patients

Номер: US20170065219A1
Автор: Santailler Gérard
Принадлежит:

An allergen exposure system includes a mixing chamber, delimited by walls and distinct from the air inlet duct and from the exposure room in which the patients are situated. A mixing between a stream of allergen particles from an allergen injection device and a flow of air devoid of allergens which has passed through a filtration device, occurs through a phenomenon of microturbulence in this mixing chamber which forms a widening with respect to the air inlet duct and makes it possible to obtain a flow of air laden with allergen particles which is injected into the exposure room through at least one diffusion outlet so that it can be inhaled by the patients. This invention is of benefit to medical and pharmaceutical research in the field of allergy study. 1. An allergen exposure system comprising:an allergen injection device;an air inlet duct;an exposure room containing the air containing allergen particles obtained by mixing a flow of allergen particles from an allergen injection device and a flow of air devoid of allergens fed in through the air inlet duct, this exposure room being designed to accommodate patients inhaling the air containing allergen particles to cause an allergic provocation;a mixing chamber, contained by walls, separate from the air inlet duct and the exposure room, in which occurs said mixture between the flow of allergen particles and the flow of air devoid of allergens; at least one allergen inlet, connected to the outlet of the allergen injection device and through which the flow of allergen particles penetrates;', 'at least one air inlet, connected to the air inlet duct and through which the flow of air devoid of allergens penetrates;', 'at least one diffusion outlet connected to the exposure room and through which a flow of air containing allergen particles, obtained by mixing in the mixing chamber the flow of air devoid of allergens and the flow of allergen particles, escapes towards the exposure room;, 'the mixing chamber compriseswherein ...

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Номер записи: 93
09-03-2017 дата публикации

Wound exudate monitor accessory

Номер: US20170065751A1
Автор: Landy Aaron Toth
Принадлежит: Convatec Technologies Inc

A stand-alone system for assessing wound exudates from the wound of a patient is described. The system contains functionality to detect, process and report various wound parameters. The system also may make treatment determinations based on these findings. The system may detect one or more physiological values of the wound exudates from the wound of the patient. The system may also compare detected physiological values to predetermined physiological values, in order to obtain a comparison result in real time. The system may include a processor ( 15 ) which provides an electronic signal based on the comparison result in which the electronic signal may corresponds to guidelines for treating the wound ( 3 ). The system described may be an accessory, which may be used on its own, or in conjunction with other wound treatment devices ( 9 ).

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Номер записи: 94
11-03-2021 дата публикации

Breathing circuit systems and devices

Номер: US20210069450A1
Автор: Brian Gerster, Charles Rosebrook, Jacob Koch, Kevin Winkler, Kleve Heavin, Natasha Reynolds, Patrick COLEMAN, Thomas W. McGrail, Yun Siung Tony Yeh
Принадлежит: Ambu AS

A filler device includes a distal housing comprising a distal inner port and a distal outer port; a proximal housing comprising a proximal inner port and a proximal outer port, the proximal housing being sealingly affixed to the distal housing to form an inspiratory pathway between the distal inner port and the proximal inner port and to form an expiratory pathway between the distal outer port and the proximal outer port that is fluidly sealed from the inspiratory pathway, the inspiratory pathway being laterally adjacent the expiratory pathway; and a first filter in the inspiratory pathway or in the expiratory pathway to filter gases flowing through the inspiratory pathway or the expiratory pathway.

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Номер записи: 95
16-03-2017 дата публикации

Dry Powder Delivery System and Method

Номер: US20170071505A1
Автор: Han Steve, Stenzler Alex
Принадлежит:

A dry powder inhalation device includes in certain embodiments a spin chamber and a cartridge for holding multiple capsules. The capsules contain a dry powder that in certain embodiments includes methacholine. In certain embodiments, an adjustable limiting mechanism is configured to limit inhaled volume through the second passageway. In certain embodiments, the cartridge moves linearly or radially though a portion of the device. In certain embodiments, capsules in the cartridge align with a port in the spin chamber to load into the spin chamber. User inhalation on a mouthpiece of the device generates a vortical airflow and causes the capsules to spin within the chamber, releasing a portion of the dry powder for inhalation. In certain embodiments, the device is used for an inhalation diagnostic challenge. The inhalation diagnostic challenge can be automated, using a graphical user interface, an imaging system, user feedback mechanisms, and electromechanical components within the device for automating device operation. 1. A dry powder delivery device comprising:a mouthpiece comprising a proximal and distal opening with a first passageway extending therebetween;a spin chamber comprising a port and an ejection door, wherein the spin chamber is connected to the first air passageway;a housing comprising a second passageway, wherein the second passageway is connected to the first passageway and further comprises an airflow sensor;a controller operably connected to the airflow sensor; anda cartridge comprising a plurality of dry powder receptacles that are configured to align with the port as the cartridge moves relative to the housing.2. The dry powder delivery device of claim 1 , wherein the second passageway comprises an adjustable limiting mechanism configured to limit inhaled volume through the second passageway.3. The dry powder delivery device of claim 2 , wherein the adjustable limiting mechanism is configured to limit inhaled volume through the second passageway to ...

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Номер записи: 96
16-03-2017 дата публикации

NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

Номер: US20170071851A1
Автор: BELL Robert Gerard, CRYSTAL Roger, KEEGAN Fintan, WEISS Michael Brenner
Принадлежит:

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. 2. The method of claim 1 , wherein the opioid of Formula (I) is selected from the group consisting of fentanyl claim 1 , 2 claim 1 ,5-dimethylfentanyl claim 1 , 3-allylfentanyl claim 1 , 3-methylbutyrfentanyl claim 1 , 3-methylfentanyl claim 1 , 3-methylthiofentanyl claim 1 , 4-fluorobutyrfentanyl claim 1 , p-chloroisobutyrfentanyl claim 1 , p-fluoroisobutyrfentanyl claim 1 , 4-fluorofentanyl claim 1 , 4-phenylfentanyl claim 1 , 4-methoxybutyrfentanyl claim 1 , acrylfentanyl claim 1 , α-methylacetylfentanyl claim 1 , α-methylbutyrfentanyl claim 1 , α-methylfentanyl claim 1 , α-methylthiofentanyl claim 1 , acetylfentanyl claim 1 , alfentanyl claim 1 , benzylfentanyl claim 1 , β-hydroxyfentanyl claim 1 , β-hydroxythiofentanyl claim 1 , β-methylfentanyl claim 1 , butyrfentanyl claim 1 , brifentanyl claim 1 , carfentanyl claim 1 , cyclopentylfentanyl claim 1 , isobutyrfentanyl claim 1 , furanylfentanyl claim 1 , furanylethylfentanyl claim 1 , lofentanyl claim 1 , N-methylcarfentanyl claim 1 , methoxyacetylfentanyl claim 1 , mirfentanyl claim 1 , ocfentanyl claim 1 , ohmefentanyl claim 1 , R-30490 claim 1 , remifentanil claim 1 , sufentanyl claim 1 , thenylfentanyl claim 1 , thiofentanyl claim 1 , trefentanyl claim 1 , and valerylfentanyl.3. The method of claim 1 , wherein the spray is delivered as a round plume with an ovality ratio less than about 1.5 when measured at 3 cm.4. The method of claim 3 , wherein the pharmaceutical solution further comprises between about 0.2% and about 1.2% (w/v) of an isotonicity agent.5. The method of claim 4 , wherein the pharmaceutical solution further comprises between about 0.005% and about 0.015% (w/v) of a preservative.6. The method of claim 5 , wherein the ...

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Номер записи: 97
05-03-2020 дата публикации

Portable inhalation therapeutic and inhalation and exhalation measuring devices and related methods

Номер: US20200069891A1
Автор: Ashmit GUPTA, Kirsten COLLIER, Terrence MCGUCKIN
Принадлежит: Argospire Medical Inc

A portable inhalation device includes a medication storage component, a flow controller, an atomizer, a medication delivery component, and a pressure sensor. The medication storage component is configured to store medication. The flow controller is configured to cause a force to be applied to the medication stored by the medication storage component to transport the medication to the atomizer. The atomizer is configured to generate droplets from the medication. The medication delivery component includes a delivery channel extending from the atomizer to an outlet opening. The medication delivery component is configured to receive the medication in the delivery channel from the atomizer and dispense the medication via the opening. The pressure sensor is configured to detect a pressure corresponding to a flow rate of air in the delivery channel and output an indication of the detected pressure.

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Номер записи: 98
18-03-2021 дата публикации

DEVICE AND METHOD FOR REMOVING UNDESIRABLE BIOLOGICAL AND/OR CHEMICAL ENTITIES FROM BIOLOGICAL FLUIDS

Номер: US20210077707A1
Автор: FABBRI Francesco, FICI Pietro, GALLERANI Giulia, RIGAUD MICHEL, ZOLI Wainer
Принадлежит:

A device removing a biological and/or chemical entity (C) from extracorporeal blood (B) is disclosed. The device has a hollow capture chamber with an inlet for the entry of the extracorporeal blood (B) and an outlet for the outflow of the extracorporeal blood (B) and a capture element inside the capture chamber having a reactant surface placed in contact with the extracorporeal blood (B) and a plurality of binding agents (A) for the biological and/or chemical entity to be removed (C) such that the biological and/or chemical entity (C), upon exiting the capture chamber, is removed from the extracorporeal blood (B) as linked to the reactant surface. 1. A method for the ex-vivo removal of a biological and/or chemical entity (C) from an extracorporeal blood volume (B) comprising: i) being rotatable about a longitudinal axis (a) of the capture chamber;', 'ii) having a reactant surface for contacting the extracorporeal blood (B),said reactant surface comprising a plurality of binding agents (A) for the biological and/or chemical entity to be removed (C), and', 'iii) a coupling and uncoupling system configured such that the capture element can be removed from the capture chamber to allow analysis of entities captured by the reactant surface,, 'a) introducing the extracorporeal blood (B) into a hollow capture chamber having a cylindrical shape, an inlet for the entry of the extracorporeal blood (B), an outlet for the outflow of the extracorporeal blood (B) and a capture element extending longitudinally within the capture chamber and movable relative to the capture chamber, the capture elementb) filtering the extracorporeal blood (B) by contact with the reactant surface having the plurality of binding agents (A) for the biological and/or chemical entity (C) to be removed; andc) extracting the extracorporeal blood (B) devoid of said biological and/or chemical entity (C) from the capture chamber;wherein the total volume of extracorporeal blood (B) flowing inside the capture ...

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Номер записи: 99
18-03-2021 дата публикации

PORTABLE HALOTHERAPY DEVICE FOR AEROSOLIZING SALT

Номер: US20210077756A1
Автор: GLASGOW Anne R, HILLIARD Aubrey L.
Принадлежит: INFINITY SALT AIR MACHINE, LLC

A portable halotherapy device includes a housing, a grinding chamber with a grinding blade that breaks apart dry granular salt into salt particles small enough for halotherapy, an air duct routing air to the chamber, a fluid conduit, and a high-speed exhaust fan. Ambient air flows through the air ducts into the grinding chamber to produce a first air current. Air is diverted from the first air current upward, in a second air current, through the fluid conduit and the fan. The first air current helps move dry granular salt around and against the grinding chamber, breaking it into small salt particles. The second air current is arranged relative to the first air current such that small salt particles, but not larger pieces, are carried as salt aerosol upward through the fluid conduit and fan for distribution to the environment, thereby facilitating a halotherapy session. 1. A portable halotherapy device , comprising:(a) one or more housings that may be coupled together to define a single operational unit;(b) a grinding chamber, having an interior with a moving grinding blade therein, that is disposed within the one or more housings and that breaks apart dry granular salt in the interior thereof into salt particles small enough to be used for halotherapy;(c) an air intake assembly, including one or more air ducts that each route ambient air from outside the one or more housings into the interior of the grinding chamber;(d) a fluid conduit that is disposed within the one or more housings and that has an inlet at a first end and an outlet at a second end, wherein the conduit extends upward from the first end, wherein the inlet is in fluid communication with the interior of the grinding chamber; and(e) an exhaust unit, the exhaust unit including a high-speed fan disposed within the one or more housings at the second end of the fluid conduit and in communication with the outlet thereof;(f) wherein the moving grinding blade and the high-speed fan together operate to produce ...

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Номер записи: 100