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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 23152. Отображено 100.
26-07-2018 дата публикации

Устройство для измерения объема ткани удаленного препарата

Номер: RU0000181705U1
Автор: Максим Валерьевич Ткачев
Принадлежит: Максим Валерьевич Ткачев

Полезная модель относится к измерительной технике и может применяться для определения объема при удалении ткани молочной железы в онкологии. Цель создания полезной модели - увеличение точности измерения, что приведет к значимому улучшению эстетического результата операции за счет правильно подобранного по объему эндопротеза, повышение удобство для переноса устройства, погружения и извлечения ткани молочной железы. Эта цель достигается тем, что устройство для измерения объема ткани удаленного препарата выполнено в форме пластиковой колбы (1) объемом от 2000 мл до 3000 мл, колба снабжена двумя вертикальными ручками (2) и метками уровня с ценой деления 20 мл. К пластиковой колбе с помощью металлической цепочки длиной не менее 400 мм зафиксирована бельевая цапка (3) с возможностью подвешивания на наружный корпус устройства на крючок (4). 1 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 181 705 U1 (51) МПК A61M 37/00 (2006.01) A61F 2/00 (2006.01) G01F 17/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61M 37/00 (2006.01); A61F 2/00 (2006.01); G01F 17/00 (2006.01) (21)(22) Заявка: 2018101327, 15.01.2018 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Ткачев Максим Валерьевич (RU) Дата регистрации: 26.07.2018 (56) Список документов, цитированных в отчете о поиске: "Пластиковая посуда (45) Опубликовано: 26.07.2018 Бюл. № 21 R U (54) Устройство для измерения объема ткани удаленного препарата (57) Реферат: Полезная модель относится к измерительной тем, что устройство для измерения объема ткани технике и может применяться для определения удаленного препарата выполнено в форме объема при удалении ткани молочной железы в пластиковой колбы (1) объемом от 2000 мл до онкологии. Цель создания полезной модели 3000 мл, колба снабжена двумя вертикальными увеличение точности измерения, что приведет к ручками (2) и метками уровня с ценой деления 20 значимому улучшению эстетического результата мл. ...

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Номер записи: 1
05-02-2019 дата публикации

Аппликатор для введения ректальной свечи

Номер: RU0000186840U1
Автор: Юрий Александрович Шолин
Принадлежит: Юрий Александрович Шолин

Полезная модель относится к технической области медицинских инструментов и может быть использована в качестве инструмента для самостоятельного ректального введения лекарственных свечей, а для медицинских учреждений - одноразового инструмента того же назначения. Аппликатор содержит полый цилиндрический корпус со сквозным проходом, фланцем на нерабочем конце и сопряженным с корпусом подвижным опорным диском. Внутренний диаметр цилиндрического корпуса выполнен меньшим наибольшего диаметра предполагаемой для введения свечи. Размещенный в корпусе шток-поршень выполнен в виде штока с диском-толкателем, диаметр которого равен внутреннему диаметру корпуса, с ограничителем перемещения штока, выполненным в виде диска, установленного от наружного торца диска-толкателя на расстояние равное длине корпуса, и с нажимным диском на конце штока. Ограничитель перемещения штока может быть выполнен также в виде штифта, а опорный диск, установленный на корпусе, выполнен фрикционно-подвижным. Для удержания конической свечи от выхода после введения, свечу в отверстии входной части корпуса аппликатора следует закреплять за ее часть с большим диаметром. Технический результат заключается в возможности изготовления заявляемого аппликатора с использованием материалов технологии, и оборудования для серийного производства одноразовых шприцов. 1 з.п. ф-лы, 3 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 186 840 U1 (51) МПК A61M 31/00 (2006.01) A61M 37/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61M 31/00 (2018.08); A61M 37/00 (2018.08) (21)(22) Заявка: 2018139142, 06.11.2018 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Шолин Юрий Александрович (RU) Дата регистрации: 05.02.2019 (56) Список документов, цитированных в отчете о поиске: RU 78674 U1, 10.12.2008. RU 180349 U1, 08.06.2018. RU 11075 U1, 16.09.1999. RU 172024 U1, 26.06.2017. (45) Опубликовано: 05.02.2019 Бюл. № 4 1 8 6 8 4 0 (54) АППЛИКАТОР ...

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Номер записи: 2
02-02-2012 дата публикации

System and method for pain reduction during skin puncture and breakable tip therefor

Номер: US20120029422A1
Автор: David Schiff, Michael Goldberg, Steven Goldberg
Принадлежит: Individual

An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

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Номер записи: 3
09-02-2012 дата публикации

Tattoo stencil composition and method for manufacturing

Номер: US20120031301A1
Автор: Russell Edmond Blette
Принадлежит: Russell Edmond Blette

The present invention is a tattoo stencil chemical composition comprising stearic acid, triethanolamine, a humectant to retain moisture on a user's skin, water and a preservative chemical composition that includes 56% propylene glycol, 30% diazolidinyl urea, 11% methylparaben and 3% propylparaben. The tattoo stencil chemical composition can also be sterilized by gamma rays or ethylene oxide and injected into a flexible wipe, one or more packets or a bulk hands free dispenser. The invention also includes a method for manufacturing a tattoo stencil chemical composition.

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Номер записи: 4
15-03-2012 дата публикации

Isoform nell-1 peptide

Номер: US20120065574A1
Автор: Chia Soo, Kang Ting
Принадлежит: UNIVERSITY OF CALIFORNIA

This application generally relates to an isoform Nell-1 peptide, compositions thereof, and methods of using the same.

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Номер записи: 5
12-04-2012 дата публикации

Piezoelectric element driver

Номер: US20120089081A1
Автор: Hieu Tieu, Wahng Chao Uei, Yuchen Zhou
Принадлежит: Hieu Tieu, Wahng Chao Uei, Yuchen Zhou

The invention teaches a palm-held massage device which includes a driver that drives one or more massage elements which provides massage vibrations in one or more ultrasonic and subsonic frequencies, a controller that provides commands to the driver, a signal generator that provides frequency references to the driver, a power supply coupled to a contactless charger, and a specimen dispensing system.

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Номер записи: 6
19-04-2012 дата публикации

Ultrasound transducer and cooling thereof

Номер: US20120095371A1
Автор: Ariel Sverdlik, Or Shabtay
Принадлежит: Cardiosonic Ltd

An ultrasonic transducer device for producing ultrasonic beams comprises a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused, or alternatively a focused, power beam for tissue ablation, the power beam being produced by vibration over the body of the transducer and emanating from the extent of the surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.

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Номер записи: 7
19-04-2012 дата публикации

Ultrasound catheter for providing a therapeutic effect to a vessel of a body

Номер: US20120095389A1
Автор: Frederick J. Bennett, Gary Lichttenegger, James E. Rodriguey, John Zhang, Katsuro Tachibana
Принадлежит: Ekos LLC

The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.

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Номер записи: 8
26-04-2012 дата публикации

Locally targeted anti-fibrotic agents and methods of use

Номер: US20120101325A1
Автор: Elaine Lee, John Scott Surfus
Принадлежит: Kyphon SARL

Effective devices and methods using an antifibrotic agent are provided for treating fibrosis or treating normal fibrous tissue. The devices and methods comprise an antifibrotic agent to degrade shrink, relax or stretch at least a portion of the fibrotic tissue. In some embodiments, the methods and devices are configured to immediately release an effective amount of the antifibrotic agent within 24 hours. In some embodiments, when the device comes in contact directly or indirectly with an activator, the antifibrotic agent will be immediately released from the depot. In some embodiments, the depot provides sustained release of the antifibrotic agent over a period of up to one year to treat fibrous tissue.

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Номер записи: 9
03-05-2012 дата публикации

Solid dose delivery device

Номер: US20120109046A1
Автор: Henrik Ljunggreen, Torben Strøm HANSEN
Принадлежит: Novo Nordisk AS

The invention relates to a medicament delivery device ( 1, 100 ) for delivering one or more solid dose pegs ( 10, 110 ) through the skin. The device ( 1, 100 ) has a number of exit openings ( 9, 109 ) corresponding to the number of solid dose pegs ( 10, 110 ) to be delivered. A detachable portion ( 3, 103 ) of the device ( 1, 100 ) is removed before use to uncover the exit openings ( 9, 109 ) and a release rod ( 17, 117 ). When the exit openings ( 9, 109 ) are pressed against the skin the release rod ( 17, 117 ) automatically disables a safety mechanism adapted to prevent unintended activation of the device ( 1, 100 ).

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Номер записи: 10
03-05-2012 дата публикации

Transdermal Fluid Delivery Device

Номер: US20120109065A1
Автор: Larry P. Backes
Принадлежит: TYCO HEALTHCARE GROUP LP

A transdermal fluid delivery device includes a housing defining a longitudinal axis and having a proximal end and a distal end. The housing defines a passageway extending longitudinally therethrough. A fluid reservoir is disposed at the proximal end of the housing in communication with the passageway of the housing and is adapted for retaining a fluid therein. A base member is positioned at the distal end of the housing. A microneedle assembly including a plurality of microneedles extending distally therefrom is also provided. The microneedle assembly is selectively moveable with respect to the housing between a retracted position, wherein the microneedles are disposed within the housing, and an extended position, wherein the microneedles are advanced distally to penetrate the base member and extend distally therefrom for puncturing the patient's epidermis and delivering the fluid into the patient's bloodstream.

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Номер записи: 11
10-05-2012 дата публикации

Drug delivery medical devices

Номер: US20120116305A1
Автор: John E. Papp
Принадлежит: Abbott Cardiovascular Systems Inc

Medical devices for delivering a bioactive agent and methods of use thereof are provided. The medical devices include micro-needles integrated within a balloon of a catheter. The balloon can include dimples, cavities or a variable thickness membrane in which the micro-needles are integrated.

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Номер записи: 12
31-05-2012 дата публикации

Low-pressure biolistic barrels

Номер: US20120135526A1
Автор: Kenneth Greenberg
Принадлежит: UNIVERSITY OF CALIFORNIA

Low pressure biolistic barrels and biolistic devices including the same are provided. Aspects of the biolistic barrels include the presence of one or more pressure-reducing elements. Also provided are kits which include the biolistic barrels, as well as methods of delivering a molecule to a target site with the biolistic barrels and devices that include the same. The devices and methods described herein find use in a variety of applications, including in vivo and in vitro high-precision delivery applications.

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Номер записи: 13
21-06-2012 дата публикации

Gas-Enhanced Surgical Instrument with Mechanism for Cylinder Puncture

Номер: US20120157911A1
Автор: Kathy E. Rooks, Russell Hempstead
Принадлежит: TYCO HEALTHCARE GROUP LP

A surgical instrument for providing an ionized gas to a surgical site includes a receptacle for at least one cylinder of pressurized surgical gas and a frame having a port near the distal end for emitting the surgical gas. A passageway extending between the receptacle and the port delivers the surgical gas to the port. A puncture assembly for rupturing a seal on at least one cylinder to release the surgical gas into the passageway includes at least one bank for storing mechanical energy which may include at least one spring. An actuator is operable to actuate the at least one bank release the mechanical energy. At least one puncture pin is operatively coupled to the at least one bank such that energy released by the at least one bank is effective to move the at least one puncture pin relative to at least one cylinder to rupture the seal.

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Номер записи: 14
21-06-2012 дата публикации

Movable curved needle for delivering implants and methods of delivering implants

Номер: US20120158009A1
Автор: Isaac Ostrovsky, Jozef Slanda, Michael S.H. Chu
Принадлежит: Boston Scientific Scimed Inc

In one general aspect, a medical device can include a base having a guide and a handle. The medical device can also include a needle member that has a curved portion and a handle portion. The curved portion of the needle member can be configured to slidably move within the guide of the base from a first position to a second position different than the first position when the handle portion of the needle member is moved towards the handle of the base.

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Номер записи: 15
28-06-2012 дата публикации

Uveoscleral drug delivery implant and methods for implanting the same

Номер: US20120165933A1
Автор: David Haffner, Kenneth Curry
Принадлежит: Dose Medical Corp

Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.

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Номер записи: 16
12-07-2012 дата публикации

Compact Device That Rapidly Mixing and Deliverings Substances To a Patient

Номер: US20120179137A1
Автор: Arthur L. Chlebowski, Barry J. Davignon, II Rush L. Bartlett, Jared L. WEST, Peter M. Greco, JR., Zachary R. Gosnell
Принадлежит: GLUCAGO LLC

Injection devices are disclosed for injections of substances. The disclosed devices separately may hold two separate substances, e.g., solid, liquid or gas substances, in separate compartments which are interrupted so that the separate substances come into contact during the activation of the device. One disclosed device includes a needle for injection and two substances that are mixed with only a few actions by the operator of the device. The device may or may not activate mixing by the removal of a sleeve which triggers compartment interaction through movement of pins, pegs, springs, wires, string, or other mechanisms which allow the materials held in separate chambers to come into contact with each other. Operator error during mixing and checking the dosage of substances to be injected is avoided with the disclosed devices. Also, the needle is maintained in a sterile state because the needle is held internally of the device until the sleeve is removed and the device begins to activate.

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Номер записи: 17
09-08-2012 дата публикации

Systems for remote generation of electrical signal in tissue based on time-reversal acoustics

Номер: US20120203306A1
Автор: Armen P. Sarvazyan
Принадлежит: Artann Laboratories Inc

A time-reversal acoustics system includes a transmitter configured to send a high intensity acoustic waveform signal focused on an implantable receiver. The receiver includes a piezoelectric transducer configured to convert received acoustic energy to an electrical signal used to energize an internal electrical circuit. Such circuit may be used to operate at least one tissue stimulating electrode, at least one sensor such as an ECG sensor, charge an internal battery or perform another useful function. The system of the invention may be used as a wireless cardiac pacemaker or a neurostimulator.

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Номер записи: 18
16-08-2012 дата публикации

Optimized Placement of Cannula for Delivery of Therapeutics to the Brain

Номер: US20120209110A1
Автор: Dali Yin, Krystof S. Bankiewicz
Принадлежит: UNIVERSITY OF CALIFORNIA

Methods and systems are provided for improved delivery of agents to targeted regions of the brain, by the use of placement coordinates that provide for optimal placement of delivery cannula. By optimizing the cannula placement, reproducible distribution of infusate in the targeted region of the brain is achieved, allowing a more effective delivery of therapeutics to the brain.

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Номер записи: 19
20-09-2012 дата публикации

Methods of electric field induced delivery of compounds, compositions used in delivery, and systems of delivery

Номер: US20120238943A1
Автор: Jun Ge, Richard N. Zare
Принадлежит: Leland Stanford Junior University

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like.

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Номер записи: 20
20-09-2012 дата публикации

Medicament Dispensing Devices and Methods

Номер: US20120238995A1
Автор: Michael I. Lewis
Принадлежит: CYTO BIOTICS LLC

A medicament dispensing device including a substantially rigid carpule body which has a dispensing end and an actuation end opposite the dispensing end. The carpule body is substantially tubular and thus defines a carpule bore. The device further includes a plunger operatively disposed within the carpule bore having a plunger actuator near the actuation end of the carpule body and a plunger tip opposite the plunger actuator. The plunger tip and an orifice at the dispensing end of the carpule bore define a medicament volume which may be loaded with a medicament selected to achieve specific therapeutic goals. The carpule body may also include a wound depth scale. The depth scale is typically associated with the dispensing end of the carpule body. Similarly, the medicament dispensing device may include a dosage scale. Also disclosed are methods of dispensing medicaments.

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Номер записи: 21
20-09-2012 дата публикации

Drug Delivery Method Via Brain Extracellular Space and a Device Thereof

Номер: US20120239000A1
Автор: Hongbin Han
Принадлежит: Individual

The present invention relates to a method for drug delivery via brain extracellular space (ECS). It includes putting head of patient in an imaging apparatus; generating dynamic images of the brain via the imaging apparatus; delivering drugs into brain ECS of the patient according to the dynamic images and the drugs get to the therapeutic target by simple diffusion along concentration gradient. The present invention also relates to a device for drug delivery via brain ECS. Basing on the self-diffusion delivery (SDD) of drugs in brain ECS, the present invention can deliver drug into the ECS of the brain's relatively safe area in low speed, with small amounts of doses and without extra stress. Therefore, the present invention can reduce delivery time and dose of drugs, relieve injection pressure, decrease damages on normal brain tissue, and reduce the cost of treatment observably.

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Номер записи: 22
27-09-2012 дата публикации

Glucose Monitoring System

Номер: US20120245445A1
Автор: Anita Margarette Chambers, Michael Darryl Black, Trent Huang
Принадлежит: Individual

A body fluid sampling system for use on a tissue site includes a drive force generator and one or more microneedles operatively coupled to the drive force generator. Each of a microneedle has a height of 500 to 2000 μm and a variable tapering angle of 60 to 90°. A sample chamber is coupled to the one or more microneedles. A body fluid is created when the one or more microneedles pierces a tissue site flows to the sample chamber for glucose detection and analysis.

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Номер записи: 23
11-10-2012 дата публикации

Wound care method and system with one or both of vacuum-light therapy and thermally augmented oxygenation

Номер: US20120259266A1
Автор: Tony Quisenberry
Принадлежит: Thermotek Inc

A combination therapy pad that includes a first layer and a second layer operatively coupled to the first layer. A fiber-optic array is disposed between the first layer and the second layer. A third layer is operatively coupled to the first layer. The third layer includes a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source. The third layer provides at least one of vacuum therapy and therapeutic fluid treatment to a wound area.

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Номер записи: 24
18-10-2012 дата публикации

Transdermal Delivery of Medicinal Cetylated Fatty Esters using Phonophoresis or Iontophoresis

Номер: US20120265119A1
Автор: Jack Bain Bookout, Raj R. Barathur
Принадлежит: Cymbiotics Inc

The use of phonophoresis or iontophoresis to enhance transdermal delivery of medicinal Cetylated fatty esters when applied in cream or gel compositions is disclosed. These compositions provide hydrophilic salt forms and penetration-enhancing vehicles that work in conjunction with phonophoresis or iontophoresis to increase the efficacy of the medicinal actives.

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Номер записи: 25
01-11-2012 дата публикации

Systems and methods for collecting fluid from a subject

Номер: US20120277697A1
Автор: Donald E. Chickering, III, Li Yang Chu, Mark Michelman, Ramin Haghgooie, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device.

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Номер записи: 26
08-11-2012 дата публикации

Method of molding a microneedle

Номер: US20120280428A1
Автор: Dennis E. Ferguson, Donald L. Pochardt, Satinder K. Nayar
Принадлежит: 3M Innovative Properties Co

A method of molding a microneedle including providing a mold apparatus having a mold insert having the negative image of at least one microneedle, a compression core, a mold housing configured to allow a reciprocal motion between the mold insert and the compression core. The method includes placing the mold apparatus in a closed position, injecting polymeric material into the closed mold apparatus, compressing the injected polymeric material between the mold insert and the compression core by a reciprocal motion between the compression core and the mold insert, opening the mold, and removing a molded microneedle from the mold. The mold insert has a mold insert height and the molded microneedle has a height that is from about 90% of the mold insert height to about 115% of the mold insert height.

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Номер записи: 27
20-12-2012 дата публикации

Applying shear stress for disease treatment

Номер: US20120323223A1
Автор: Abbas Hassan, Aziz Hassan, Gregory G. Borsinger, Rayford G. Anthony
Принадлежит: HRD Corp

A system for applying shear stress ex-situ to a fluid. A method of preparing a fluid for intravenous administration to a patient. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient.

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Номер записи: 28
27-12-2012 дата публикации

Micro-needle device

Номер: US20120330250A1
Автор: Kazuya Machida, Seiji Tokumoto, Tetsuji Kuwahara
Принадлежит: Hisamitsu Pharmaceutical Co Inc

An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 μm including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm 2 is applied to the micro-needle device 1 which is in contact with the skin.

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Номер записи: 29
03-01-2013 дата публикации

Nanoporous Membrane Responsive to Electrical Stimulation and Method for Manufacturing the Same

Номер: US20130006180A1
Автор: Gumhye Jeon, Jin Kon Kim, Jinseok Byun, Seung Yun Yang
Принадлежит: Academy Industry Foundation of POSTECH

The present invention relates to a nanoporous membrane for flux control in response to electrical stimulation. The nanoporous membrane includes a supporting layer with a plurality of pores; and an electrically responsive layer that is connected to around the entrances of the pores and undergoes a volume change by oxidation or reduction caused by electrical stimulation to thereby lead to a change in pore size.

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Номер записи: 30
10-01-2013 дата публикации

Methods and systems for ultrasound treatment

Номер: US20130012842A1
Автор: Peter G. Barthe
Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment are provided. Acoustic energy, including ultrasound, can serve as input energy to a mask with apertures, such apertures acting as secondary acoustic sources to create a modulated output acoustic energy in a treatment region and treatment effects. Under proper control output energy can be precisely placed and controlled in tissue. In some embodiments, methods and systems are configured for ultrasound treatment based on creating an output energy distribution in tissue. In some embodiments, methods and systems are configured based on creating an output temperature distribution in tissue.

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Номер записи: 31
21-02-2013 дата публикации

Ocular ultrasound probe

Номер: US20130046179A1
Автор: Mark S. Humayun
Принадлежит: Mark S. Humayun

Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.

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Номер записи: 32
28-02-2013 дата публикации

Space-efficient containment devices and method of making same

Номер: US20130053671A1
Автор: Robert Farra
Принадлежит: MicroChips Inc

Containment devices and methods of manufacture and assembly are provided. In an embodiment, the device includes at least one microchip element, which includes a containment reservoir that can be electrically activated to open, and a first electronic printed circuit board (PCB) which comprises a biocompatible substrate. The first PCB may have a first side on which one or more electronic components are fixed and an opposed second side on which the microchip element is fixed in electrical connection to the one or more electronic components. The device may further include a second PCB and a housing ring securing the first PCB together with the second PCB. The microchip element may include a plurality of containment reservoirs, which may be microreservoirs, and/or which may contain a drug formulation or a sensor element.

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Номер записи: 33
14-03-2013 дата публикации

Implants for administering substances and methods of producing implants

Номер: US20130064965A1
Автор: Andrew P. Bowditch, Christopher P. Barrett, Leigh T. Canham, Peter J. Wright, Timothy I. Cox
Принадлежит: pSiMedica Ltd

A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In a second embodiment the implant may have a large number of holes which contain beneficial substance and which are closed by bio-erodible doors of different thickness so as to stagger the release of the beneficial substance over time as the doors are breached.

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Номер записи: 34
21-03-2013 дата публикации

Device and method for treating central nervous system pathology

Номер: US20130072827A1
Автор: David L. Carroll, Jie Liu, Louis C. Argenta, Michael J. Morykwas, Nicole H. Levi, Stephen Tatter, William D. Wagner
Принадлежит: Wake Forest University Health Sciences

The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.

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Номер записи: 35
21-03-2013 дата публикации

Device having array provided with fine protrusions

Номер: US20130072874A1
Автор: Seiji Tokumoto, Shuji ISHITSUKA, Toshiyuki Matsudo
Принадлежит: Hisamitsu Pharmaceutical Co Inc

An array 1 provided with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0<(a/b)≦7.5 holds.

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Номер записи: 36
21-03-2013 дата публикации

MICRONEEDLE ASSEMBLY FORMULATION FOR SKIN TREATMENT

Номер: US20130072902A1
Автор: Ono Ichiro, Takada Kanji
Принадлежит:

A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar. 114-. (canceled)15. A microneedle assembly formulation for use in prevention or treatment of skin aging , or treatment of skin scar comprising a platform and a plurality of conical or pyramidal microneedles formed on said platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in said base , whereinsaid objective substance is at least one selected from the group consisting of various growth factors acting on skin cells and substances promoting production of said growth factors in skin cells;the content of the objective substance is from 0.01 μg to 1.0 mg/patch; anda target symptom for prevention or treatment is skin aging, UV-damaged skin, hypertrophic scar, atrophic scar, keloids, acne scar, hair loss, suture wound, burn wound, ulcer, bedsore, diabetic ulcer or a disease requiring angiogenesis.16. The microneedle assembly formulation for skin treatment according to claim 15 , wherein each of said microneedles has a first member with a tip part containing the objective substance and a second member with a bottom part not containing the objective substance.17. The microneedle assembly ...

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Номер записи: 37
28-03-2013 дата публикации

Device, Method, and System for Neural Modulation as Vaccine Adjuvant in a Vertebrate Subject

Номер: US20130079582A1
Автор: Della Rocca Gregory J., Dowling Joshua L., Goodall Eleanor V., Hyde Roderick A., Ishikawa Muriel Y., JR. Lowell L., Kare Jordin T., Leuthardt Eric C., Malaska Stephen L., Myhrvold Nathan P., Santiago Paul, Stewart Todd J., Sweeney Elizabeth A., Tegreene Clarence T., Wood, Wood Victoria Y. H.
Принадлежит: SEARETE LLC

A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject. 180.-. (canceled)81. A method for eliciting an enhanced immune response to a neoplasm in a vertebrate subject comprising:providing at least one energy stimulus from one or more transducers, wherein the at least one energy stimulus is configured to modulate one or more nervous system components in a tissue of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are configured to provide in a combination and in a temporal sequence sufficient to enhance an immune response to the one or more immunogen in the vertebrate subject.82. The method of claim 81 , wherein the at least one energy stimulus includes one or more of electrical energy claim 81 , magnetic energy claim 81 , electromagnetic energy claim 81 , ultrasonic energy claim 81 , acoustic energy claim 81 , mechanical energy claim 81 , or thermal energy.83. The method of claim 82 , wherein the at least one energy stimulus includes at least one energy characteristic having one or more of waveform claim 82 , frequency claim 82 , amplitude claim 82 , or duration.84. The method of claim 81 , wherein the neoplasm includes a neoplasm in one or more of a lymphoid tissue claim 81 , a myeloid tissue claim 81 , a hematopoietic tissue claim 81 , a nervous tissue claim 81 , an epithelial tissue claim 81 , an endothelial tissue claim 81 , or a muscle tissue.85. The method of claim 81 , wherein the one or more immunogen includes one or more ...

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Номер записи: 38
28-03-2013 дата публикации

MULTIPURPOSE SURGICAL SPONGEPADS, DEVICES, SYSTEMS, AND METHODS

Номер: US20130079590A1
Автор: Bengtson Bradley P.
Принадлежит:

Novel surgical sponge-pad devices that are highly absorbent, durable, and reusable are presented. The technical features of the surgical sponge-pad devices make possible unique surgical sponge-pad systems and methods that take advantage of the use, conditioning, and reuse of a single surgical sponge device again and again during a surgical procedure. The invention provides surgical-sponge-pad devices, systems, and methods that make possible a significant reduction in the number of surgical sponges needed for a given surgical procedure. In addition this multifunctional surgical sponge-pad will have significant and brand new applications in surgery for the protection and hydration of tissues, transmission of antibiotics and antimicrobials and other solutions, barriers in surgery and even use in transfer of transplanted organs as well as many other future medical and surgical uses as yet undefined and undiscovered. 1. A reusable multi-use surgical sponge-pad for use during medical procedures comprising:an absorbent material possessing a capability to quickly absorb bodily fluids, said absorbent material also possessing the capability of being rinsed and reused repetitively during the same procedure.2. The surgical sponge-pad of claim 1 , wherein the absorbent material is lint-free.3. The surgical sponge-pad of claim 1 , wherein the absorbent material is selected from the group consisting of: polyvinyl alcohol claim 1 , polyurethane claim 1 , and polyvinyl acetate.4. The surgical sponge-pad of claim 3 , wherein the absorbent material is polyvinyl acetate.5. The surgical sponge-pad of further comprising antibacterial material.6. The surgical sponge pad of further comprising an antimicrobial material.7. The surgical sponge pad of claim 1 , wherein the surgical sponge pad is capable of retaining fluid during the medical procedure claim 1 , whereby the surgical pad sufficiently moistens exposed tissue during the medical procedure and keeps the exposed tissue from ...

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Номер записи: 39
28-03-2013 дата публикации

ULTRASOUND-NEUROMODULATION TECHNIQUES FOR CONTROL OF PERMEABILITY OF THE BLOOD-BRAIN BARRIER

Номер: US20130079682A1
Автор: Mischelevich David J.
Принадлежит:

Disclosed are methods and systems and methods employing non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier. For example, such an alteration can permit increased penetration of a medication to increase its therapeutic effect. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency (carrier and/or neuromodulation frequency), pulse duration, firing pattern, and phase/intensity relationships for beam steering and focusing on targets and accomplishing up-regulation and/or down-regulation. 1. A method for altering a permeability of a blood-brain barrier in a patient , the method comprising:aiming at least one ultrasound transducer at least one target in a brain or a spinal cord of a human or animal, andenergizing at least one transducer to deliver pulsed ultrasound energy to the at least one target,wherein permeability of the blood-brain barrier in the vicinity of the target is altered.2. The method of wherein the transducer is controlled to deliver ultrasound pulsed power that increases the permeability of the blood-brain barrier.3. The method of further comprising administering a drug to the patient wherein the effectiveness of the drug is enhanced by increased penetration of that drug into the target because of the increase in permeability of the blood-brain barrier.4. The method of wherein the transducer is controlled to deliver ultrasound pulsed power which decreases the permeability of the blood-brain barrier.5. The method of further comprising administering a drug to the patient wherein the side effects of the drug are reduced due to decreased penetration of the drug into the target because of the decrease in permeability of the blood-brain barrier.6. The method of wherein a target is selected to have permeability to a drug increased ...

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Номер записи: 40
04-04-2013 дата публикации

MICRONEEDLE NASAL DELIVERY DEVICE

Номер: US20130085472A1
Автор: Shaari Christopher
Принадлежит: Toxcure, LLC

The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more microneedles. In certain embodiments, the nasal delivery device comprises a substrate for administration of a composition to the nasal and/or sinus mucosa, wherein the substrate is non-absorbent and comprises one or more microneedles. In some embodiments, the nasal delivery device comprises a reservoir comprising one or more therapeutic agents, wherein the reservoir is in fluid communication with one or more microneedles. 1. A nasal delivery device comprising a substrate suitable for administration of a composition to a nasal or sinus mucosa , wherein the substrate comprises one or more microneedles.2. (canceled)3. The nasal delivery device of claim 1 , wherein the substrate is selected from the group consisting of: cotton claim 1 , a sponge claim 1 , an inflatable balloon claim 1 , a probe claim 1 , a roller claim 1 , and a polymeric silicone elastomer.4. The nasal delivery device of claim 1 , wherein the at least one or more microneedles are 150 micrometers or less in length.5. The nasal delivery device of claim 1 , wherein the nasal delivery device comprises a reservoir in fluid communication with the microneedle.6. The nasal delivery device of claim 5 , wherein the reservoir comprises an injection port.7. The nasal delivery device of claim 5 , wherein the device comprises a shaft.8. (canceled)9. (canceled)10. The nasal delivery device of claim 6 , wherein the injection port is suitable for attachment of a syringe.11. The nasal delivery device of claim wherein the one or more microneedles are hollow.12. The nasal delivery device of claim 1 , wherein the one or more microneedles are porous.13. The nasal delivery device of claim 1 , wherein the substrate is cotton claim 1 , wherein the cotton is attached to one end of a shaft claim 1 , and the one or more microneedles are ...

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Номер записи: 41
11-04-2013 дата публикации

LOCALIZATION OF AGENTS AT A TARGET SITE WITH A COMPOSITION AND AN ENERGY SOURCE

Номер: US20130090591A1
Автор: FERRARA Katherine W., Kheirolomoom Azedah
Принадлежит: The Regents of the University of California

A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source. 1. A method for localized delivery of an agent to a target site , comprising:administering a composition to a subject, wherein the subject comprises the target site and the composition comprises an agent-transition metal complex; andirradiating the target site with an energy source, the irradiating causing accumulation of the agent-transition metal complex at the target site or release of the agent-transition metal complex from the composition at the target site, thereby producing localized delivery of the agent to the target site.2. The method of claim 1 , wherein the administered composition further comprises a liposome comprising a 63:7:25:5 molar ratio of DPPC:DSPC:chol:DSPE-PEG2k claim 1 , wherein the liposome comprises the complex claim 1 , wherein the agent is doxorubicin claim 1 , wherein the transition metal is copper (II) claim 1 , wherein the energy source is ultrasound claim 1 , wherein the target site comprises a tumor claim 1 , and wherein the method further comprises administering rapamycin to the subject.3. The method of claim 1 , wherein the agent is doxorubicin.4. The method of claim 1 , wherein the agent is an anthracycline.5. The method of claim 4 , wherein the anthracycline is selected from the group consisting of: daunorubicin claim 4 , doxorubicin claim 4 , epirubicin claim 4 , idarubicin claim 4 , mitoxantrone claim 4 , valrubicin claim 4 , and irinotecan.6. The method of claim 3 , wherein the transition metal is copper.7. The method of claim 6 , wherein the molar ratio of doxorubicin to copper in the composition is 2:1.8. The method of claim 6 , wherein the molar ratio of doxorubicin to copper in the composition is 1:1.9. The method of claim 3 , wherein the doxorubicin concentration in the composition is less than 50 mM claim 3 ...

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Номер записи: 42
18-04-2013 дата публикации

METHODS FOR REGENERATING SKELETAL MUSCLE

Номер: US20130095078A1
Автор: Dominko Tanja, Makridakis Jennifer, Malcuit Christopher, Page Raymond Lynn, Pins George D.
Принадлежит:

An engineered muscle construct in the form of a braided collagen microthread scaffold is provided. The microthread scaffold can be used with or without cells as engineered skeletal muscle. The microthread scaffold can also be used to promote cell attachment and growth to deliver cells to a large muscle defect to stimulate muscle regeneration. Methods for making a muscle construct, seeding cells onto microthread scaffolds and treating muscle defects are also provided. 1. A composition comprising a polymer configured as a plurality of microthreads , each having a leading end and a trailing end for use as a therapeutic agent or device for repairing muscle tissue defects.2. The composition of claim 1 , further comprising a plurality of biological cells in association with the microthreads claim 1 , and claim 1 , optionally claim 1 , a therapeutic agent.3. The composition of claim 1 , further comprising a surface modification of the plurality of microthreads.4. The composition of claim 1 , wherein the polymer configured as a plurality of microthreads comprises a naturally occurring polymer.5. The composition of claim 4 , wherein the naturally occurring polymer is collagen or fibrin.6. The composition of claim 1 , wherein the microthreads are braided claim 1 , bundled or tied to form filaments.7. The composition of claim 1 , wherein the microthreads have a diameter of about 0.2-100 μm.8. The composition of claim 2 , wherein the cells are differentiated cells selected from the group consisting of: muscle-derived cells claim 2 , muscle-derived fibroblastic cells claim 2 , skeletal muscle satellite cells claim 2 , satellite like cells claim 2 , primary skeletal muscle cells claim 2 , fibroblasts claim 2 , and endothelial cells.9. The composition of claim 8 , wherein the cells is are muscle-derived fibroblastic cells.10. The composition of claim 2 , wherein the cells are undifferentiated or dedifferentiated cells selected from the group consisting of: dedifferentiated ...

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Номер записи: 43
18-04-2013 дата публикации

SYSTEMS AND METHODS FOR TREATING INJURIES TO JOINTS AND CONNECTIVE TISSUE

Номер: US20130096471A1
Автор: Barthe Peter G., Slayton Michael H.
Принадлежит: GUIDED THERAPY SYSTEMS, LLC

According to various embodiments, methods and systems useful for treating injuries to joints are provided herein. In some embodiments, methods and systems useful for permanent relief of pain in joints are provided herein. Various embodiments provide for combining therapeutic ultrasound energy directed to a joint with a medicant injected into the joint. 1. A method of treating an injury in a joint , the method comprising:targeting injured fibrous soft tissue located in at least one of at and proximate to an injury location comprising a portion of a joint;directing therapeutic ultrasound energy to the injured fibrous soft tissue;creating a conformal region of elevated temperature in the injured fibrous soft tissue; andcreating at least one thermally induced biological effect in the injured fibrous soft tissue.2. The method according to claim 1 , wherein the thermally induced biological effect is at least one of coagulation claim 1 , increased perfusion claim 1 , reduction of inflammation claim 1 , generation of heat shock proteins claim 1 , and initiation of healing cascade.3. The method according to claim 1 , further comprising targeting a capsule in the portion of the joint; and treating inflamed tissue at or proximate to the capsule.4. The method according to claim 1 , further comprising driving a medicant into the injured soft fibrous tissue.5. The method according to claim 4 , further comprising activating the medicant with the therapeutic ultrasound energy claim 4 , wherein the medicant is a steroid.6. The method according to claim 1 , further comprising peaking inflammation in the injury location and initiating a coagulation cascade in at least a portion of the joint.7. The method according to claim 1 , further comprising welding a portion of the injured fibrous soft tissue with the conformal ultrasound energy and repairing a tear in the portion of the joint.8. The method according to claim 1 , further comprising stimulating collagen growth in a portion of the ...

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Номер записи: 44
18-04-2013 дата публикации

METHODS FOR USING ULTRASOUND FOR ENHANCING EFFICIENCY AND TARGETING OF INTRANASAL ADMINISTRATION OF THERAPEUTIC COMPOUNDS TO THE CENTRAL NERVOUS SYSTEM

Номер: US20130096488A1
Автор: Frey, II William H.
Принадлежит: HealthPartners Research & Education

The present invention is directed to methods for reducing systemic absorption of therapeutic compounds or agents while enhancing efficiency of delivery and targeting of intranasal administration of such compounds or agents to the central nervous system. More specifically, use of ultrasound technology in conjunction with intranasal delivery of a therapeutic compound, or pharmaceutical composition, wherein the intranasal delivery is preferably to the upper one third of a patient's nasal cavity, thereby reducing therapeutic compound or agent absorption into the blood. At the same time, the present invention results in reducing the delivery of therapeutic compounds and/or agents to the peripheral tissues, increases therapeutic delivery of the compounds and/or agents to the central nervous system generally, and increases targeting of the therapeutics and/or agents to specific target regions within the central nervous system. 1. A method for transporting an effective dose comprising at least one therapeutic agent and/or compound to a damaged or degenerating or injured central nervous system of a mammal , wherein the damage or degeneration or injury is caused by a neurological disease or condition or trauma within at least one region of the central nervous system , comprising:administering the effective dose to the nasal cavity of the mammal;enabling at least some of the effective dose comprising at least one therapeutic agent and/or compound of the effective dose to directly access the damaged or degenerating or injured central nervous system by bypassing the blood-brain barrier of the mammal, wherein at least a portion of the at least one therapeutic agent and/or compound of the effective dose enters the mammal's bloodstream and/or the perivascular spaces of blood vessels of the mammal's cerebrovasculature;allowing a time period to pass;after passage of the time period, focusing ultrasound energy on at least one selected target region corresponding to the at least one ...

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Номер записи: 45
18-04-2013 дата публикации

WOUND TREATMENT SYSTEM AND METHOD OF USE

Номер: US20130096490A1
Автор: Pelkus Adrian
Принадлежит: IYIA TECHNOLOGIES, INC.

A wound treatment system including a treatment chamber, a source of an aqueous antibiotic, a source of an oxygen-enriched gas, and a control system adapted to alternately surround a human limb with antibiotic mist and the oxygen enriched gas, which can be used to heal lesions such as foot ulcers. A method of treating lesions such as foot ulcers is also disclosed, that includes bathing the lesion in antibiotic mist and contacting it with oxygen gas. 1. A method for treating a wound , comprising:(a) introducing a human limb having a wound into a treatment chamber;(b) surrounding the limb in the treatment chamber with a mist containing water and an antibiotic; and{'sub': '2', '(c) surrounding the limb in the treatment chamber with an O-enriched gas without increasing the pressure around the foot to 22 mm Hg.'}2. The method of claim 1 , wherein the wound is a chronic lesion.3. The method of claim 1 , wherein the wound is a post-surgical infection claim 1 , a gangrenous lesion claim 1 , a decubitus ulcer claim 1 , or a venous stasis.4. The method of claim 1 , wherein the wound is a skin ulceration due to amputation claim 1 , skin graft claim 1 , burn claim 1 , or frostbite.5. The method of claim 1 , wherein the limb is a foot.6. The method of claim 1 , wherein the limb is a leg.7. The method of claim 1 , wherein the antibiotic is a topical antibiotic.8. The method of claim 1 , wherein the antibiotic is selected from betadine claim 1 , isopropyl alcohol claim 1 , bacitracin claim 1 , and hydrogen peroxide claim 1 , and combinations thereof.9. The method of claim 1 , wherein the antibiotic is ionic silver.10. The method of claim 1 , wherein the O-enriched gas displaces the mist.11. The method of claim 1 , wherein the O-enriched gas is substantially pure O.12. The method of further comprising repeating the treatment periodically until the foot ulcer is healed.13. The method of claim 1 , wherein step (b) is performed for about 2 to about 30 minutes.14. The method of claim 12 ...

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Номер записи: 46
18-04-2013 дата публикации

CLOSED CELL CULTURE SYSTEM

Номер: US20130096491A1
Автор: Suzuki Shigeki
Принадлежит: NEXT21 K.K.

An object of the present invention is to provide a tissue cell culture system whereby a call tissue can be efficiently and quickly proliferated in vivo and the onset bacterial infection in an injured part can be avoided in the course of a treatment. More specifically, a closed cell culture system () characterized in that a defection () of a tissue on the body surface or inside the body is tightly sealed to form a closed environment free from the invasion of bacteria, etc. and then a solution appropriate for cell culture is circulated in the tissue defection thus sealed to thereby regenerate the defective tissue; and a method of administering a drug which comprises dissolving a remedy in the perfusion with the use of the above system and thus promoting the treatment of the defection. 1. A closed cell culture system , comprising: to be embedded within a tissue defect inside a body of a patient to form a cell proliferation site, and', 'to be a foundation to which regenerating tissue cells within the proliferation site can adhere and proliferate as the tissue defect heals and closes up;, 'a bioabsorbable material configureda perfusion introduction tube configured to provide a solution to the bioabsorbable material;a perfusion discharge tube configured to discharge the solution; anda circuit for circulating the solution, the circuit perfusing the solution within the tissue defect by way of an entrance portion of the perfusion introduction tube, the circuit discharging the solution from the tissue defect by way of an exit portion of the perfusion discharge tube, the solution being appropriate for cell culture;wherein the closed cell culture system is capable of regenerating tissue at the cell proliferation site of the tissue defect,the closed cell culture system further comprising:a puncture needle and a balloon catheter, the balloon catheter passing through and within the puncture needle and being inflated to create the tissue defect.2. The closed cell culture system ...

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Номер записи: 47
18-04-2013 дата публикации

Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery

Номер: US20130096532A1
Автор: Milesi Nicola, Ozel Tugrul, Thepshonti Thanongsak
Принадлежит: Rutgers, The State University of New Jersey

A micro-needle array is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface, a bottom surface, a side surface, and a cavity defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface. A plurality of micro-needles on a patch is also disclosed for transdermal drug delivery applications. 1. A micro-milled patch comprising a plurality of micro-needles , said micro-needles comprising a structure comprising a base at a proximal end and a vertex or tip , defining a vertex angle , at a distal end , said needle not extending into the dermis when applied to the skin , wherein said micro-needle is optionally biodegradable.2. The patch of claim 1 , wherein said micro-needles are fabricated using a biodegradable polymer.3. The patch of claim 2 , wherein said micro-needles comprise a bio-active agent.4. The patch of claim 3 , wherein said bioactive agent is a vaccine.5. The patch of claim 1 , wherein said micro-needle comprises a conical configuration.6. The patch of claim 1 , wherein said micro-needle comprises a pyramidal configuration.7. The patch of claim 1 , wherein said micro-needle comprises a cylindrical configuration.8. A single flute straight cutting edge tungsten carbide engraving tool for fabrication of micro-needles having the geometrical parameters of Table 2.9. A method for delivering a bioactive agent to a patient in need thereof comprising applying the patch of to the skin of said patient such that a bioactive agent gains access to the blood stream of said patient wherein said micro-needle does not penetrate the dermis of said ...

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Номер записи: 48
18-04-2013 дата публикации

WIRELESS TATTOO APPLICATOR

Номер: US20130096599A1
Автор: Boman Bertho, Colton Brett
Принадлежит:

A wireless, battery powered tattooing apparatus employing a stable voltage regulator to provide stable control of the operation of the tattoo applicator. A user interface enables an artist to select a desired reciprocation frequency for the needle movement of the tattoo applicator. The selected setting is used to generate a particular voltage from the voltage regulator that in turn, controls the frequency of the needle reciprocations. A wireless receiver receives operational commands to control the tattoo applicator from a remote transmitter thereby keeping the artist's hands free to work. 120-. (canceled)21. A method of controlling a tattoo apparatus wherein the tattoo apparatus comprises a tattoo applicator and a remote control unit , wherein the tattoo applicator comprises a wireless receiver to receive wireless signals , a pen assembly , storage to store a reciprocating frequency for the pen assembly , an armature operatively connected to the pen assembly , and at least one coil configured to attract the armature when the at least one coil is electromagnetic and wherein the remote control unit is physically remote from the tattoo applicator and configured to wirelessly transmit an on signal or off signal to the tattoo applicator when a switch on the remote control unit is actuated , the method comprising:storing in the tattoo applicator a reciprocating frequency for the pen assembly;electronically generating a supply voltage having a frequency based on the reciprocating frequency when an on signal is wirelessly received by the tattoo applicator; andapplying the supply voltage to the at least one coil.22. The method of further comprises resetting a timer in the tattoo applicator when an on signal is received from the remote control unit claim 21 , wherein:the supply voltage is applied to the at least one coil until an off signal is wirelessly received by the tattoo applicator or the timer reaches a predetermined value; andthe remote control unit periodically ...

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Номер записи: 49
25-04-2013 дата публикации

METHODS DEVICES AND SYSTEMS OF PREPARING TARGETED MICROBUBBLE SHELLS

Номер: US20130101521A1
Автор: Borden Mark A., Chen Cherry
Принадлежит:

Targeted microbubbles are generated by post-labeling buried ligand microbubbles. According to embodiments, buried ligand microbubbles are created with steric brushes protecting functionalized polymer tethers. Ligands were attached to the functionalized tethers by diffusion of ligands of a small size through the steric barrier. The steric barrier was substantially capable of hindering access to the tethers by larger molecules. The embodiments disclosed include methods for creating microbubble batches that can be loaded with selected ligands, for titrating the targeting ligands thereby to reduce waste and cost, and for using resulting buried ligand molecules for medical purposes. 147-. (canceled)48. A method of making microbubbles , comprising:forming size-isolated microbubbles with a first attachment component, the forming including selecting microbubbles of a first size range from microbubbles spanning a second size range;storing the size-isolated microbubbles;recovering the stored size-isolated microbubbles and attaching a second attachment component to the size-isolated microbubbles.49. The method of claim 48 , wherein the forming includes generating a cake of microbubbles.50. The method of claim 49 , wherein the storing includes storing the cake of microbubbles.51. The method of claim 49 , wherein the attaching includes diluting the cake of microbubbles.52. The method of claim 48 , wherein the forming includes incorporating a shielding component in the microbubbles and the shielding and first attachment components include PEG chains.53. The method of claim 52 , wherein the attaching includes diffusing the second attachment component through a steric overbrush formed by the shielding component.54. The method of claim 48 , wherein the size-isolated microbubbles include a surface of amphiphilic phospholipids that are self-assembled in the forming to form a lipid monolayer shell.55. The method of claim 48 , further comprising using the size-isolated microbubbles as a ...

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Номер записи: 50
25-04-2013 дата публикации

Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof

Номер: US20130102993A1
Автор: Hyun Ryoung KIM, Jae Chan Park, Min Sang Kim, Sang Joon Park, Su Young Chae
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A liposome including an elastin-like polypeptide (ELP) and a tumor cell targeting material, a pharmaceutical composition including the liposome, and a method of delivering an active agent to a target site using the liposome.

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Номер записи: 51
02-05-2013 дата публикации

Gas-enhanced surgical instrument with mechanism for cylinder puncture

Номер: US20130110033A1
Автор: Kathy E. Rooks, Russell D. Hempstead
Принадлежит: COVIDIEN LP

A surgical instrument for providing an ionized gas to a surgical site includes a receptacle for at least one cylinder of pressurized surgical gas and a frame having a port near the distal end for emitting the surgical gas. A passageway extending between the receptacle and the port delivers the surgical gas to the port. A puncture assembly for rupturing a seal on at least one cylinder to release the surgical gas into the passageway includes at least one bank for storing mechanical energy which may include at least one spring. An actuator is operable to actuate the at least one bank release the mechanical energy. At least one puncture pin is operatively coupled to the at least one bank such that energy released by the at least one bank is effective to move the at least one puncture pin relative to at least one cylinder to rupture the seal.

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Номер записи: 52
02-05-2013 дата публикации

GEL ASSEMBLY

Номер: US20130110040A1
Автор: Serpe Michael J.
Принадлежит: GOVERNORS OF THE UNIVERSITY OF ALBERTA

A gel assembly comprising a polymeric gel layer between metal layers. A gel assembly process comprising providing a colloidal polymer in solution, drying the solution to form a polymeric gel layer and forming metal layers on either side of the polymeric gel layer. A method of drug delivery comprising loading a polymeric gel layer with drug, forming metal layers on either side of the polymeric gel layer, wherein the polymeric gel layer comprises a material that is sensitive to a stimulus, and subjecting the polymeric gel layer to the stimulus to release the drug from between or through the metal layers. 1. A gel assembly comprising a polymeric gel layer between metal layers.2. The gel assembly of in which the polymeric gel layer comprises at least a monomer having at least an atom with a free electron pair per monomer unit.3. The gel assembly of in which the atom with a free electron pair comprises one or more of nitrogen claim 2 , fluorine claim 2 , chlorine claim 2 , or phosphorus atoms.4. The gel assembly of in which the metal layers are reflective.5. The gel assembly of in which the metal layers are parallel to each other.6. The gel assembly of in which the metal layers are sufficiently thin to be transparent.7. The gel assembly of formed as an etalon in which the metal layers have a different refractive index from the polymeric gel layer.8. The gel assembly of in which the polymeric gel layer comprises a stimulus responsive material that changes volume in response to a stimulus.9. The gel assembly of in which the stimulus responsive material comprises one or more of thermoresponsive polymers claim 7 , pH responsive polymers claim 7 , electroresponsive polymers claim 7 , hydrophilic polymers claim 7 , magnetoresponsive polymers claim 7 , chemical responsive polymers claim 7 , ionic strength responsive polymers and photoresponsive polymers.10. The gel assembly of in which the polymeric gel layer is formed as a colloidal gel.11. The gel assembly of in which the ...

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Номер записи: 53
02-05-2013 дата публикации

Implant Cannula Having an Implant and a Method for Securing Implants in an Injection Cannula

Номер: US20130110077A1
Автор: Spilgies Heiko
Принадлежит: Acino AG

The application provides an injection cannula having an implant which is detachably secured in the cannula. The application also provides a method for detachably securing an implant in an injection cannula. 123-. (canceled)24. An injection cannula with an implant , wherein the implant is detachably secured in the injection cannula over at least part of at least one longitudinal side of the injection cannula with at least one physiologically tolerable material.25. The injection cannula of claim 24 , wherein the at least one physiologically tolerable material comprises one or more semi-solid materials or one or more cured materials.26. The injection cannula of claim 24 , wherein the at least one physiologically tolerable material comprises one or more semi-solid materials and one or more cured materials.27. The injection cannula of claim 25 , wherein the at least one physiologically tolerable material comprises a polymer material.28. The injection cannula of claim 26 , wherein the at least one physiologically tolerable material comprises a polymer material.29. The injection cannula of claim 24 , wherein the implant is detachably secured in the injection cannula over up to 50% of the surface area of the at least one longitudinal side.30. The injection cannula of claim 24 , wherein the implant is detachably secured in the injection cannula over at least one point on the surface of the at least one longitudinal side.31. The injection cannula of claim 24 , wherein the at least one physiologically tolerable material has a layer thickness of from 0.1 to 1.2 mm.32. The injection cannula of claim 24 , wherein the injection cannula has a lateral opening.33. The injection cannula of claim 32 , wherein the implant is arranged in a region of the lateral opening of the injection cannula.34. The injection cannula of claim 24 , wherein the implant comprises goserelin claim 24 , leuprorelin claim 24 , anastrolol claim 24 , risperidone or octreotide.35. The injection cannula of claim ...

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Номер записи: 54
02-05-2013 дата публикации

Vaccination Method Using Microneedle Arrays

Номер: US20130110078A1
Автор: "OMahony Conor", Carey John B., Crean Abina M., HILL Adrian V.S., McGrath Marie G., Moore Anne C., Pearson Frances
Принадлежит:

The present invention provides vaccination methods using microneedle arrays which, when applied to the skin of a subject, create a defined total pore volume. Arrays may be chosen of varying total microneedle volumes (small, intermediate or large) for use in immunisation regimes to induce different T-cell and antibody responses in the subject. The present invention also provides kits for use in such vaccination method(s) comprising the appropriate microneedle array(s). 1. A prime-boost vaccination method which comprises:(i) administering a priming vaccine using a microneedle array having a small total microneedle volume; and(ii) administering a boosting vaccine using a microneedle array having a large total microneedle volume.2. The prime-boost vaccination method according to claim 1 , wherein the large total microneedle volume is at least two-fold greater than the small total microneedle volume.3. The prime-boost vaccination method according to claim 1 , wherein the small total microneedle volume is between 0.0005 and 0.014 mm.4. The prime-boost vaccination method according to claim 3 , wherein the large total microneedle volume is at least 0.05 mm.5. The prime-boost vaccination method according to claim 3 , wherein the large total microneedle volume is between 0.07 and 0.25 mm.6. A kit comprising:(i) a microneedle array suitable for administering a priming vaccine having a small total microneedle volume; and(ii) a microneedle array suitable for administering a boosting vaccine having a large total microneedle volume.7. The kit according to claim 6 , wherein the microneedle array suitable for administering a priming vaccine has a total microneedle volume of between 0.0005 and 0.014 mm; and/or the microneedle array suitable for administering a boosting vaccine has a total microneedle volume of at least 0.05 mm.810-. (canceled)11. The method according to claim 1 , wherein the priming vaccine and boosting vaccine are homologous.12. The method according to claim 1 , ...

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Номер записи: 55
02-05-2013 дата публикации

SYSTEMS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS

Номер: US20130110080A1
Автор: Ducharme Richard W.
Принадлежит: Cook Medical Technologies LLC

The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. The systems generally comprise a container having first and second regions and a reservoir containing the therapeutic agent. A pressure source having pressurized fluid is in selective fluid communication with at least a portion of the reservoir. An outlet tube is in fluid communication with the reservoir of the container. At least one slot is formed in a lateral surface of the outlet tube at a position between first and second ends of the outlet tube. 1. A system suitable for delivering a therapeutic agent to a target site , the system comprising:a container for holding the therapeutic agent, wherein the container comprises first and second regions and has a reservoir containing the therapeutic agent;a pressure source having pressurized fluid, the pressure source in selective fluid communication with at least a portion of the reservoir of the container;an outlet tube in fluid communication with the reservoir of the container; andat least one slot formed in a lateral surface of the outlet tube at a position between first and second ends of the outlet tube.2. The system of claim 1 , where the first end of the outlet tube is disposed closer to a target site and the second end of the outlet tube is disposed proximal to the first end claim 1 , where the at least one slot is positioned closer to the first end than the second end of the outlet tube.3. The system of where the at least one slot extends between about 45 and about 270 degrees around a perimeter of the outer tube.4. The system of wherein fluid from the pressure source is directed through the first region of the container in a direction towards the second region of the container claim 1 , and wherein the fluid is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the ...

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Номер записи: 56
09-05-2013 дата публикации

Self-Assembled, Micropatterned, and Radio Frequency (RF) Shielded Biocontainers and Their Uses for Remote Spatially Controlled Chemical Delivery

Номер: US20130116541A1
Автор: Gracias David H., Leong Timothy Gar-Ming, Ye Hongke
Принадлежит: JOHNS HOPKINS UNIVERSITY

The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. 139-. (canceled)40. A method for imaging a three-dimensional particle or biocapsule that has been implanted into a subject , wherein the three-dimensional particle or biocapsule comprises a plurality of two-dimensional faces capable of self-folding to form a hollow interior , wherein a size of the particle or biocapsule is microscale or nanoscale , and wherein the plurality of two-dimensional faces comprise a folding hinge between two adjacent faces and a locking or sealing hinge on an edge of a two-dimensional face , wherein the folding hinge between two adjacent faces has a width that is about twice a width of the locking or sealing hinge on an edge , wherein the plurality of two-dimensional faces comprising the three-dimensional particle or biocapsule are permanently held together by solid hinges; (i) loading the hollow interior of the particle or biocapsule with at least one substance to form a loaded particle or biocapsule;', '(ii) administering the loaded particle or biocapsule to the subject; and', '(iii) noninvasively tracking the particle or biocapsule of step (ii) in the subject by magnetic resonance imaging or CAT scan (CT)., 'the method comprising41. The method according to claim 40 , wherein the particle or biocapsule ...

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Номер записи: 57
09-05-2013 дата публикации

Anchored Working Channel

Номер: US20130116549A1
Автор: Gerrans Lawrence J., Gunday Erhan H., Hsia Alex
Принадлежит:

An anchored working channel includes an elongated shaft with a proximal end and a distal end, and at least one inflatable balloon positioned at the distal end of the elongated shaft and having an outer wall having an outer surface for contacting surrounding tissue, wherein the elongated shaft has a first lumen through which fluid is supplied to inflate the at least one inflatable balloon such that the balloon anchors the shaft to surrounding tissue, wherein the elongated shaft has a second lumen that accommodates at least one medical instrument and/or device inserted therein, and wherein the outer surface of the at least one inflatable balloon comprises a textured surface for preventing slippage of the outer surface on surrounding tissue. 1. An anchored working channel comprising:an elongated shaft with a proximal end and a distal end; andat least one inflatable balloon positioned at the distal end of the elongated shaft and having an outer wall, said outer wall comprising an outer surface for contacting surrounding tissue;wherein the elongated shaft has a first lumen through which fluid is supplied to inflate said at least one inflatable balloon such that said at least one balloon anchors the shaft to surrounding tissue;wherein the elongated shaft has a second lumen that accommodates at least one medical instrument and/or device inserted therein; andwherein said outer surface of said at least one inflatable balloon comprises a textured surface for preventing slippage of the outer surface on surrounding tissue.2. The anchored working channel of claim 1 , wherein said textured surface of said at least one inflatable balloon comprises a mesh disposed on the outer wall of said balloon.3. The anchored working channel of claim 2 , wherein the mesh is a weft knit mesh.4. The anchored working channel of claim 2 , wherein the mesh comprises polyethylene.5. The anchored working channel of claim 2 , wherein the mesh comprises elastane.6. The anchored working channel of claim ...

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Номер записи: 58
09-05-2013 дата публикации

BACTERIUM-BASED MICROROBOT INCLUDING MAGNETIC PARTICLES

Номер: US20130116621A1
Автор: PARK Jong Oh, PARK Suk Ho, Park Sung Jun
Принадлежит: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

Provided is a bacterium-based microrobot, wherein bacteria are attached to a part of a surface of a microstructure including at least one or more magnetic particle, for actuating a bacterium-based microrobot more effectively. 1. A bacterium-based microrobot comprising a microstructure comprising one or more magnetic particles , wherein the bacteria are attached to a part of the surface of the microstructure.2. The bacterium-based microrobot of claim 1 , wherein the magnetic particles comprise a ferromagnetic substance.3. The bacterium-based microrobot of claim 1 , wherein the microstructure comprises a drug and the magnetic particles are dispersed in the drug.4. The bacterium-based microrobot of claim 1 , wherein the microstructure has a core/shell structure.5. The bacterium-based microrobot of claim 1 , wherein the microstructure has a multilayer structure.6. The bacterium-based microrobot of claim 1 , further comprising a drug-encapsulated bead in which a drug is encapsulated.7. The bacterium-based microrobot of or claim 1 , further comprising a therapeutic bacterium-encapsulated bead in which therapeutic bacteria are encapsulated.8. The bacterium-based microrobot of claim 3 , wherein the drug is an anticancer drug claim 3 , a radionuclide claim 3 , a therapeutic drug for ischemic diseases claim 3 , or a therapeutic drug for infarction.9. The bacterium-based microrobot of claim 1 , wherein the bacteria are selectively attached to the part of the surface of the microstructure.10. The bacterium-based microrobot of claim 9 , wherein the bacteria are selectively attached to the part of the surface of the microstructure by controlling surface energy of the part of the surface of the microstructure.11. The bacterium-based microrobot of claim 10 , wherein if the surface of the microstructure is made of a hydrophilic material claim 10 , the part of the surface of the microstructure is modified to be hydrophobic claim 10 , or if the surface of the microstructure is made of ...

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Номер записи: 59
16-05-2013 дата публикации

AQUEOUS FORMULATIONS FOR COATING MICRONEEDLE ARRAYS

Номер: US20130123707A1
Автор: Determan Amy S., Hansen Kristen J., Johnson Peter R., Moseman Joan T., WOLDT RYAN T.
Принадлежит: 3M INNOVATIVE PROPERTIES COMPANY

Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein. 1. A method of forming a coated microneedle array comprisingproviding a microneedle array comprising a microneedle substrate and a plurality of microneedles;providing a coating substrate;{'sup': '−1', 'providing an aqueous formulation comprising at least one active pharmaceutical ingredient and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.;'}applying the aqueous formulation to the coating substrate;bringing the aqueous formulation and the microneedles of the microneedle array into contact with one another;removing the microneedles from the aqueous formulation; andallowing at least a portion of the aqueous formulation to evaporate.2. The method according to claim 1 , wherein the viscosity is from 500 to 10 claim 1 ,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.3. The method according to claim 1 , wherein the viscosity is from 500 to 8 claim 1 ,000 centipoise when measured at a shear rate of 100 sand a temperature of 25° C.4. The method according to claim 1 , wherein the aqueous formulation has a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions.5. The method according to claim 1 , wherein the aqueous formulation has a contact angle on a medical grade polymeric material of 65° or greater ...

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Номер записи: 60
23-05-2013 дата публикации

Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject

Номер: US20130131435A1
Автор: Clarence T. Tegreene, Eleanor V. Goodall, Elizabeth A. Sweeney, Eric C. Leuthardt, Gregory J. Della Rocca, Jordin T. Kare, Joshua L. Dowling, Lowell L. Wood, JR., Muriel Y. Ishikawa, Nathan P. Myhrvold, Paul Santiago, Roderick A. Hyde, Stephen L. Malaska, Todd J. Stewart, Victoria Y.H. Wood
Принадлежит: SEARETE LLC

A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.

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Номер записи: 61
23-05-2013 дата публикации

METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS

Номер: US20130131598A1
Автор: Chen Guohua, SHASTRY Ashutosh, Singh Parminder, Trautman Joseph C., Worsham Robert Wade
Принадлежит: CORIUM INTERNATIONAL, INC.

Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. 1. A needle array , comprising:a base;a plurality of needle portions each having a tip region having a tapered shape and a plurality of basement regions each having a tapered shape, where the basement regions are arranged on a first surface of the base at a proximal end of each of the basement regions, and each of the basement regions is connected to a proximal end of the tip region at a distal end of each basement region.2. The needle array of claim 1 , wherein a diameter of each of the plurality of needle portions grows faster than linearly with increasing proximity to a proximal end.3. The needle array of claim 1 , wherein a diameter of each of the needle portion basement regions and tip regions decrease from the proximal end of the basement region to a distal end of the tip region.4. The needle array of claim 1 , wherein each of the tip regions is funnel-shaped.5. The needle array of claim 1 , wherein each of the basement regions is funnel-shaped.6. The needle array of claim 1 , wherein each of the tip regions has a conical shape and each of the basement regions has a polygonal shape.7. The needle array of claim 1 , wherein each of the tip regions and each of the basement regions comprises at least one polymer.8. The needle array of claim 1 , wherein each of the tip regions comprises a biodegradable polymer.9. The needle array of claim 7 , wherein the at least one polymer is selected from the group consisting of poly(lactic acid) claim 7 , poly(glycolic acid) claim 7 , poly(lactic acid-co-glycolic acid) claim 7 , poly(caprolactone) claim 7 , polyanhydrides claim 7 , polyamines claim 7 , polyesteramides claim 7 , polyorthoesters claim 7 , polydioxanones claim 7 , polyacetals claim 7 , polyketals claim 7 , polycarbonates claim 7 , ...

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Номер записи: 62
23-05-2013 дата публикации

NANOCHANNELED DEVICE AND RELATED METHODS

Номер: US20130131629A1
Автор: Goodall Randy, Grattoni Alessandro, HOSALI Sharath, Hudson Lee, Mann Aman P.
Принадлежит: The Board of Regents of the Unversity of Texas System

Apparatus and methods of delivering a therapeutic agent using an implant comprising a nanochannel delivery device. 1. An apparatus configured to deliver a therapeutic agent , the apparatus comprising:an orthopedic implant;a reservoir; anda nanochannel delivery device in fluid communication with the reservoir.2. The apparatus of claim 1 , wherein the orthopedic implant is configured for implantation into one of the bone group consisting of: femur claim 1 , tibia claim 1 , maxillofacial claim 1 , shoulder claim 1 , humerus claim 1 , radius claim 1 , ulna claim 1 , wrist claim 1 , ankle claim 1 , hip claim 1 , knee claim 1 , or spine.3. The apparatus of claim 1 , wherein the orthopedic implant comprises a cage structure.4. The apparatus of claim 3 , wherein the cage structure is configured to surround a sponge.5. The apparatus of wherein the reservoir comprises a therapeutic agent.6. The apparatus of wherein the nanochannel delivery device is configured to control the release of the therapeutic agent from the reservoir.7. The apparatus of wherein the reservoir comprises one or more of the following: an antibiotic claim 1 , analgesic claim 1 , anti-inflammatory compound claim 1 , or growth factor.8. The apparatus of wherein the reservoir comprises Bone Morphogenetic Protein.9. The apparatus of wherein the apparatus comprises a protective member configured to protect the nanochannel delivery device from contact with the surrounding environment.10. The apparatus of wherein the protective member is configured as a screen with apertures.11. An apparatus configured to deliver a therapeutic agent claim 9 , the apparatus comprising:a nanochannel delivery device, wherein the nanochannel delivery device comprises a plurality of macrochannels, microchannels and nanochannels;wherein the macrochannels are configured to form a reservoir containing the therapeutic agent.12. The apparatus of wherein the nanochannel delivery device is configured for implantation in a human eye.13. The ...

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Номер записи: 63
30-05-2013 дата публикации

Skin Permeation Device for Analyte Sensing or Transdermal Drug Delivery

Номер: US20130137951A1
Автор: Debashis Ghosh, HAN Chuang, James P. Hurley, Juan P. Eslava, Keith Krystyniak, Scott C. Kellogg
Принадлежит: Echo Therapeutics Inc

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece. The abrasive tip can be made of any material with a surface that can abrade skin. The material can be conductive or non-conductive. The controlled abrasion device may be provided in a kit, where the kit contains the device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time. The desired level of skin impedance, and thus the resulting permeability of the treated site, can be set at a predetermined value. Alternatively, the level of skin impedance can be selected based on the desired level of skin integrity, the subject's sensation of discomfort, or the duration of the application. The device contains a control mechanism which uses an appropriate algorithm or signal processing on the conductivity information provided by the electrodes to determine when the desired level of skin permeability has been reached. Once the desired ...

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Номер записи: 64
30-05-2013 дата публикации

Delivering and/or receiving fluids

Номер: US20130138058A9
Автор: A. David Boccuti, Christopher J. Morse, Donald E. Chickering, III, Greg Fisher, Javier Gonzalez-Zugasti, Maisam Dadgar, Mark Michelman, Ramin Haghgooie, Richard L. Miller, Scott James, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

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Номер записи: 65
30-05-2013 дата публикации

Tatooing Machine and Tattooing Machine Armature Assembly

Номер: US20130138130A1
Автор: Nizov Sergei Nikolaevich
Принадлежит:

A tattooing machine armature assembly is provided, said tattooing machine armature assembly comprising an armature, an armature spring, a contact spring, and a locking screw, wherein the armature is mounted on the armature spring by means of the locking screw so as to oscillate, wherein the armature is embodied with a hook while the contact spring is mounted so as to cooperate with the hook of the armature. A tattooing machine is provided as well, said tattooing machine comprising a frame, a vise, one inductance coil as a minimum, a magnetic circuit, an armature, an armature spring, a contact spring, a capacitor, a bar, contact islands, locking screws, and insulation spacers, wherein the armature is mounted on the frame by means of the armature spring so as to oscillate when subjected to the magnetic field produced by the inductance coils while the bar and one of contact islands are electrically insulated from the frame, said tattooing machine comprising a stop mounted so as to intercept the contact spring at closure of the electric circuit of the apparatus while the contact spring is mounted to be pre-compressed. 1. A tattooing machine armature assembly comprising an armature , an armature spring , and a contact spring , wherein the armature is mounted on the armature spring so as to oscillate , said tattooing machine armature assembly being characterized in that the armature is embodied with a hook while an upper end of the contact spring is brought under the hook of the armature.2. The tattooing machine armature assembly according to claim 1 , characterized in that it comprises a locking screw and an elastic ring claim 1 , the armature is embodied with a bevel and is attached on the armature spring by means of the locking screw while the elastic ring is inserted into a wedge gap between the armature spring and the armature bevel and is fixed in a tensioned state by means of the locking screw.3. The tattooing machine armature assembly according to claim 1 , ...

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Номер записи: 66
06-06-2013 дата публикации

Devices, systems and methods for magnetic-assisted therapeutic agent delivery

Номер: US20130139832A1
Автор: Benjamin Shapiro, Isaac B. Rutel
Принадлежит: Individual

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.

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Номер записи: 67
06-06-2013 дата публикации

DEVICE SYSTEM AND METHOD FOR MONITORING AND CONTROLLING BLOOD ANALYTE LEVELS

Номер: US20130144144A1
Автор: LASTER Morris, PHILLIP Moshe
Принадлежит: C.G.M.3 LTD.

Systems, devices, and methods for monitoring an analyte in a subject. The systems, devices, and methods may include a sensor element being designed and configured for detecting said analyte in blood flowing through a bone of the subject, and a fixation element that is capable of fixating said sensor element within the bone tissue 1. A system for monitoring an analyte in a subject comprising a sensor element being designed and configured for detecting said analyte in blood flowing through a bone of the subject , and a fixation element that is capable of fixating said sensor element within the bone tissue.2. A system for monitoring an analyte in a subject comprising a sensor element being designed and configured for detecting said analyte in blood flowing through a bone of the subject , and a rigid implant-protecting and stabilizing device comprising an elongate body perforated by a longitudinally-disposed central bore , wherein said device is of a size and shape such that it is capable of completely or partially containing said sensor element within its central bore.3. A device for monitoring an analyte in a subject comprising a sensor element being designed and configured for detecting the analyte in blood flowing through a bone of the subject.4. The device of claim 3 , wherein the device is completely implanted within tissue of the subject.5. The device of claim 4 , wherein said sensor element is implanted within bone tissue and is designed and configured for contacting blood flowing within a blood sinus of said bone tissue.6. The device of claim 3 , wherein said sensor element is anchored to bone tissue.7. The device of claim 3 , further comprising a wireless communication unit for remotely communicating with a wireless control unit.8. The device of claim 3 , further comprising circuitry for remotely powering said sensor element.9. The device of claim 3 , wherein said analyte is glucose.10. A system for monitoring an analyte in a subject comprising a device ...

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Номер записи: 68
06-06-2013 дата публикации

INJECTION MOLDED MICRONEEDLE ARRAY AND METHOD FOR FORMING THE MICRONEEDLE ARRAY

Номер: US20130144217A1
Автор: Ross Russell Frederick
Принадлежит:

Disclosed are injection molded devices including microneedles on a substrate base. The microneedles may include a plurality of nano-sized structures fabricated thereon. The molds used to form the microneedles are assembled from a plurality of mold segments, each defining portions of the microneedles. Upon assembly of the multiple mold segments, microneedle negative cavities are formed. The molds may be used in an injection molding process to form microneedle arrays. Devices may be utilized for interacting with a component of the dermal connective tissue. 1. A method of forming a microneedle array comprising injecting a moldable material into a microneedle negative cavity , wherein the microneedle negative cavity defines a plurality of fabricated nanostructures on a surface , the nanostructures being arranged in a pattern.2. The method according to claim 1 , the method further comprising aligning a first mold segment with a second mold segment claim 1 , the first mold segment including a first microneedle segment and the second mold segment including a second microneedle segment claim 1 , wherein upon alignment of the first and second mold segments the microneedle negative cavity is formed therebetween claim 1 , the first and second microneedle segments each forming part of the microneedle negative cavity.3. The method according to or claim 1 , wherein the microneedle negative cavity defines a microneedle channel mold.43. The method according to any of - claims 1 , the method further comprising aligning a base with the microneedle negative cavity to form a substrate cavity adjacent to the microneedle negative cavity.5. The method according to any of the preceding claims claims 1 , further comprising forming a positive mold master.6. The method according to any of the preceding claims claims 1 , further comprising heating the microneedle negative cavity prior to injecting the moldable material into the microneedle negative cavity.7. The method according to any of the ...

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Номер записи: 69
06-06-2013 дата публикации

DEVICE FOR DELIVERY OF RHEUMATOID ARTHRITIS MEDICATION

Номер: US20130144257A1
Автор: Ross Russell Frederick
Принадлежит:

Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures. 1. A device for delivery of a rheumatoid arthritic drug across a dermal barrier , the device comprising:a microneedle and a plurality of nanostructures fabricated on a surface of the microneedle, the nanostructures being arranged in a predetermined pattern; anda rheumatoid arthritis drug in fluid communication with the microneedle.2. The device of claim 1 , wherein the pattern further includes microstructures claim 1 , wherein the nanostructures have a cross-sectional dimension smaller than the microstructures.3. The device of claim 2 , further comprising second nanostructures having a cross-sectional dimension less than the cross-sectional dimension of the microstructures and greater than the cross-sectional dimension of the first nanostructures.4. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers.5. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have a center-to-center spacing of from about 50 nanometers to about 1 micrometer.6. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have a height of from about 10 nanometers to about 20 micrometers.7. The medical device of any of the preceding claims claim 2 , wherein at least a portion of the nanostructures have an aspect ratio of from about 0.15 to ...

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Номер записи: 70
06-06-2013 дата публикации

STRUCTURES FOR TRANSDERMAL DRUG DELIVERY

Номер: US20130144261A1
Автор: CHOWDHURY Dewan Fazlul Hoque
Принадлежит:

A preparation for the transdermal delivery of a biologically active substance into the body of a patient comprises particles of a formulation comprising the active substance. The particles are irregular in size and shape and may be produced by a low cost manufacturing method such as grinding from a thin film. The particles are angular, i.e. they have sharp edges and corners that allow them to penetrate the outer layer of the skin when subjected to pressure from a roller or an array of blunt-tipped microstructures. Sucrose may be used as an excipient with the active substance to form suitably rigid and angular particles. 1. A preparation suitable for transdermal delivery into the body of a patient , the preparation comprising particles of a formulation that is soluble or biodegradable in the body , the particles being rigid , irregular in shape and angular , whereby they are capable of penetrating the surface of the skin or of a cornea of the patient.2. A preparation according to claim 1 , wherein the formulation comprises a biologically active substance.3. A preparation according to claim 2 , wherein the formulation further comprises at least one excipient in addition to the active substance.4. A preparation according to claim 3 , wherein the excipient is sucrose.5. A preparation according to claim 4 , wherein the ratio of sucrose to the active substance is greater than 60:40.6. A preparation according to claim 5 , wherein the ratio of sucrose to the active substance is less than 20:1.7. A preparation according to claim 1 , wherein at least 50% of the particles have at least one corner characterized in that every pair of faces of the particle that meet at the corner meet at an angle no greater than 90°.8. A preparation according to claim 1 , wherein the mean size of the particles is between 10 nm and 1 mm.9. A preparation according to claim 8 , wherein the mean size of the particles is between 1 μm and 100 μm.10. A transdermal patch comprising:a body layer;means for ...

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Номер записи: 71
13-06-2013 дата публикации

Microvascular obstruction detection and therapy

Номер: US20130150737A1
Автор: Robert A. Van Tassel, Robert S. Schwartz
Принадлежит: Osprey Medical Inc

A method of detecting and treating a microvascular obstruction is provided. In one embodiment, a catheter is provided for both detecting the microvascular obstruction and treating or removing the obstruction.

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Номер записи: 72
13-06-2013 дата публикации

METHOD AND APPARATUS FOR PROVIDING HYDRATION FLUID

Номер: US20130150823A1
Автор: Montgomery Hugh E., Mythen Michael, Thorne Anthony
Принадлежит:

The invention relates to a method and apparatus for providing hydration fluids. The invention allows for a ‘background’ rate of providing a hydration fluid to be automatically supplied by an apparatus to a patient, for example intravenously, and for the patient to receive an extra amount of hydration fluid, or ‘bolus dose’, to be provided when the patient sends a signal to the apparatus. In preferred embodiments the background supply rate, the volume and rate of supply of the bolus dose and the maximum extra volume that can be provided as bolus doses in a given time can be set, for example, by a nurse. 154.-. (canceled)55. An apparatus configured to dispense hydration fluid , the apparatus comprising:a signal input device configured to receive a signal from a user,a control unit configured to determine, in response to the signal input device receiving a signal from the user, if first dispensing criteria are met, the first dispensing criteria being based on a dispensing history of a hydration fluid for oral ingestion,the apparatus being configured such that a predetermined metered amount of hydration fluid for oral ingestion is dispensed if it is determined by the control unit that the first dispensing criteria are met,wherein the control unit is further configured, in response to the signal input device receiving the signal from the user, to determine if second dispensing criteria are met; the second dispensing criteria being based on the dispensing history of a hydration fluid for intravenous delivery, andwherein the apparatus is further configured such that a predetermined metered amount of hydration fluid for intravenous delivery is dispensed, if it is determined that the second dispensing criteria are met.56. The apparatus according to claim 55 , wherein:the control unit is further configured to determine how many times the predetermined metered amount of hydration fluid for oral ingestion has been dispensed in a first predetermined period, andwherein the ...

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Номер записи: 73
20-06-2013 дата публикации

Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface

Номер: US20130158377A1
Автор: Aria Adrianus I., Gharib Morteza, Sansom Elijah Bodhi
Принадлежит: California Institute of Technology

The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc. 1. A nano-enhanced device for substance transfer between the device and a tissue , comprising:a substrate; andan array of substantially aligned carbon nanotubes having two ends, the carbon nanotubes being anchored within the substrate with at least one end protruding from the substrate, whereby the protruding carbon nanotubes enhance the substance transfer capabilities of the device.2. The device of claim 1 , wherein the carbon nanotube array is coated with a substance selected from the group consisting of a drug and a gene.3. The device of claim 2 , wherein the carbon nanotubes have side walls and where the nanotube array contains free spaces between the carbon nanotubes claim 2 , and where the protruding ends of the anchored carbon nanotubes are free of coated substance and the substance coating area consists of an area selected from the group consisting of side walls of the carbon nanotubes and free spaces between the carbon nanotubes.4. The device of claim 2 , wherein the device is selected from the group consisting of a patch to be worn on the tissue and an angioplasty balloon.5. The device of claim 4 , wherein the drug is paclitaxel.6. The device of claim 2 , wherein delivery of the drug ...

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Номер записи: 74
20-06-2013 дата публикации

Delivering and/or receiving material with respect to a subject surface

Номер: US20130158468A1
Автор: Donald E. Chickering, III, Howard Bernstein, Ping Gong, Shawn Davis
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.

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Номер записи: 75
20-06-2013 дата публикации

RAPID DELIVERY AND/OR RECEIVING OF FLUIDS

Номер: US20130158482A1
Автор: Chickering Donald E., Davis Shawn, Haghgooie Remin
Принадлежит: Seventh Sense Biosystems, Inc.

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. 1. A microneedle structure comprising:a first plurality of microneedles that each include a base portion and a penetrating portion, the base portions of the first plurality of microneedles being arranged at the periphery of a first closed loop lying in a plane, the penetrating portions of the first plurality of microneedles each extending at a respective angle away from the plane of the first closed loop; anda second plurality of microneedles that each include a base portion and a ...

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Номер записи: 76
20-06-2013 дата публикации

MEDICAL DEVICES FOR DELIVERY OF siRNA

Номер: US20130158505A1
Автор: Ross Russell Frederick
Принадлежит:

Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles. 1. A device for delivery of an siRNA construct across a dermal barrier , the device comprising:a microneedle and a plurality of nanostructures fabricated on a surface of the microneedle, the nanostructures being arranged in a predetermined pattern; andan siRNA construct in fluid communication with the microneedle.2. The device of claim 1 , wherein the pattern further includes microstructures claim 1 , wherein the nanostructures have a cross-sectional dimension smaller than the microstructures.3. The device of claim 2 , further comprising second nanostructures having a cross-sectional dimension less than the cross-sectional dimension of the microstructures and greater than the cross-sectional dimension of the first nanostructures.4. The medical device of claim 1 , wherein at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers.5. The medical device of any of claim 1 , wherein at least a portion of the nanostructures have a center-to-center spacing of from about 50 nanometers to about 1 micrometer.6. The medical device of claim 1 , where at least a portion of the nanostructures have a height of from about 10 nanometers to about 20 micrometers.7. The medical device of claim 1 , wherein at least a portion of the nanostructures have an aspect ratio of from about 0.15 and about 30.8. The device of claim 1 , wherein the siRNA agent includes a duplexed region of between about 20 and about 30 pairs.9. The device of claim 1 , at least one ...

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Номер записи: 77
27-06-2013 дата публикации

MICRONEEDLE DEVICES AND USES THEREOF

Номер: US20130165772A1
Автор: ANDERSON Daniel G., BLANKSCHTEIN Daniel, Langer Robert S., Polat Baris Erinc, SCHOELLHAMMER Carl Magnus, Schroeder Avraham D., Traverso Carlo Giovanni
Принадлежит:

The present disclosure provides devices and uses thereof A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary. 1. A device dimensioned for administration or implantation to an internal tissue of a subject , which device includes a plurality of microneedles adapted to protrude from the device surface so that the microneedles interact with the internal tissue.2. The device of claim 1 , wherein the device is dimensioned for oral claim 1 , sublingual or intraoperative administration.3. The device of claim 1 , wherein the device is dimensioned for intravenous or respiratory administration.4. The device of claim 3 , wherein the internal tissue is a part of a vessel wall.5. The device of claim 1 , wherein the device is dimensioned for vaginal claim 1 , rectal claim 1 , urethral or bladder suppository or pessary.6. The device of any . being dimensioned and constructed to carry a payload claim 1 , which payload is delivered to the internal tissue after interaction with the microneedles.7. The device of claim 1 , wherein a target site of the subject is a viscus.8. (canceled)9. (canceled)10. The device of claim 1 , wherein a target site of the subject is in an internal GI tract.11. (canceled)12. The device of claim 1 , wherein some or all of the microneedles are hollow.13. The device of claim 12 , wherein at least one of the hollow microneedles is cannulated claim 12 , defining a channel that enables storage or introduction of the payload from the other parts of the device.14. The device of claim 1 , wherein ...

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Номер записи: 78
27-06-2013 дата публикации

Mechanical Wound Therapy for Sub-Atmospheric Wound Care System

Номер: US20130165821A1
Автор: Freedman Brett, Shuler Michael
Принадлежит: J&M SHULER MEDICAL, INC.

A mechanical wound therapy (MWT) system includes a connection for a vacuum source, which is routed through an airtight covering to a porous material positioned over the wound. The porous material may be a tubing network interspaced by a netting material constructed of biologically inert or bioabsorbable material. Alternatively, the porous material may be a layered unified dressing in which layers of mesh, netting or thin perforated film are separated and fixedly attached to functional elements of the dressing (e.g., irrigation tubing) or spacers. The vacuum and irrigation systems may be completely separated. An airtight sealing layer or foldable adhesive sealing layer may seal the dressing and facilitate sealing the dressing to the wound margins. Additional modular devices such as a wound approximating system, positive pressure bladders and adjuvant therapy modules as well as enhanced monitoring technology can be added to synergistically increase the capabilities of each dressing. 1. A unified dressing structure for a sub-atmospheric wound-care system , the unified dressing structure comprising:an airtight cover component configured as a dorsal surface of the unified dressing structure;a connector attached to the cover component and configured to connect to a line from a vacuum source; anda porous dressing component disposed as a ventral surface of the unified dressing structure and fixedly attached to the cover component, wherein the porous dressing component is configured to cover an open wound.2. The unified dressing structure of claim 1 , further comprising:an adhesive strip with a weak adhesive disposed on a perimeter edge of the cover component, said perimeter edge extending laterally beyond the porous dressing component.3. The unified dressing structure of claim 2 , wherein the adhesive strip is configured to removably affix to skin surrounding the open wound to make an airtight connection.4. The unified dressing structure of claim 1 , wherein the porous ...

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Номер записи: 79
27-06-2013 дата публикации

COMPOSITE MICRONEEDLE ARRAY INCLUDING NANOSTRUCTURES THEREON

Номер: US20130165861A1
Автор: Ross Russell Frederick
Принадлежит:

Disclosed are composite microneedles arrays including microneedles and a film overlaying the microneedles. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component. 1. A composite microneedle array comprisinga microneedle assembly that includes a plurality of microneedles; anda film overlaying the microneedles of the microneedle assembly, the film having a first surface and a second surface, the film at least partially conforming to the microneedles, wherein the first surface of the film is adhered to the microneedle assembly, the second surface of the film comprising a plurality of nanostructures formed thereon, the nanostructures being arranged in a predetermined pattern.2. The composite microneedle array according to claim 1 , at least one of the microneedles contains a channel along a length of the microneedle.3. The composite microneedle array according to any of the preceding claims claim 1 , at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers.4. The composite microneedle array according to any of the preceding claims claim 1 , wherein the pattern further comprises microstructures claim 1 , the nanostructures having a cross-sectional dimension smaller than the microstructures.5. The composite microneedle array according to claim 4 , further comprising second nanostructures having a cross-sectional dimension less than the cross-sectional ...

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Номер записи: 80
27-06-2013 дата публикации

Self-injection device having needle cover with activation preventer

Номер: US20130165866A1
Автор: Corey Christensen
Принадлежит: Becton Dickinson and Co

A drug delivery device, including a body ( 104, 116 ) having a reservoir ( 160 ) disposed therein for containing a medicament and an injection needle ( 152 ) for penetrating the skin of a patient, the needle ( 152 ) providing a path for the medicament between the reservoir ( 160 ) and the patient. The device also includes a rotor ( 580 ) rotatably disposed in the body ( 104, 116 ) for activating the device upon rotation of the rotor ( 580 ), a needle cover ( 112 ) for covering the injection needle, and a needle cover clip ( 560 ) disposed on the needle cover ( 112 ) to rotate from a first position preventing rotor rotation to a second position permitting rotor rotation.

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Номер записи: 81
27-06-2013 дата публикации

METHOD FOR PRODUCING SILICON MICRONEEDLE ARRAYS WITH HOLES AND MICRONEEDLE ARRAY

Номер: US20130165872A1
Автор: Stumber Michael
Принадлежит: ROBERT BOSCH GMBH

A method for producing silicon microneedle arrays with drilled holes includes producing a silicon microneedle array. For each microneedle in a plurality of microneedles in the microneedle array, a laser is positioned relative to a microneedle and a drilled hole is drilled into the microneedle array by laser drilling. The drilled holes are drilled in microneedles, in flanks of the microneedles or alongside microneedles. A microneedle array includes a substrate composed of a micromechanical semiconductor material. The microneedle array has microneedles that project from the substrate and has drilled holes. The microneedles are composed of a porous micromechanical semiconductor material. 1. A method for producing microneedle arrays composed of a micromechanical semiconductor material with drilled holes comprising:producing a microneedle array composed of the micromechanical semiconductor material with a flat side and a needle side; and positioning a laser relative to a microneedle in the microneedle array; and', 'drilling a hole into the microneedle array by laser drilling, 'for each microneedle in a plurality of microneedles of the microneedle array2. The method according to claim 1 , wherein the microneedle array comprises a crystalline silicon.3. The method according to claim 1 , wherein the microneedle array comprises porous silicon.4. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the drilled hole is drilled in the microneedle.5. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the hole is drilled in a flank of the microneedle.6. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the hole is drilled alongside the microneedle.7. The method according to claim 1 , wherein the laser is positioned relative to the microneedle such that the hole is drilled from the needle side of the microneedle array.8. The ...

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Номер записи: 82
27-06-2013 дата публикации

MICRONEEDLE ARRAY APPLICATOR AND METHOD FOR APPLYING A MICRONEEDLE ARRAY

Номер: US20130165902A1
Автор: Daub Martina, Stumber Michael
Принадлежит: ROBERT BOSCH GMBH

A microneedle array applicator is configured to apply a microneedle array in cosmetic and medical applications. The microneedle array applicator has a holding apparatus configured to define detachable holding of a microneedle array comprising a planar substrate. The microneedle array applicator also has a drive mechanism for driving the microneedle array in a first direction perpendicular to the planar substrate and in a second direction parallel to the planar substrate. A method for applying a microneedle array includes the microneedle array applicator enabling safe breaking off of the microneedles, optionally laden with an active ingredient, in the skin. 1. A microneedle array applicator for applying a microneedle array in cosmetic and medical applications comprising:a holding apparatus for defined detachable holding of a microneedle array comprising a planar substrate; anda drive mechanism configured to drive the microneedle array in a first direction perpendicular to the planar substrate and in a second direction parallel to the planar substrate.2. The microneedle array applicator according to claim 1 , wherein the drive mechanism has a first actuator configured to provide drive in the first direction and a second actuator configured to provide drive in the second direction.3. The microneedle array applicator according to claim 1 , wherein the drive mechanism has a deflection apparatus configured to deflect a movement of the microneedle array from the first direction into the second direction.4. The microneedle array applicator according to claim 1 , wherein the drive mechanism has a striking apparatus configured to drive the microneedle array.5. The microneedle array applicator according to claim 1 , wherein the drive mechanism is configured to carry out a rotational movement of the microneedle array.6. The microneedle array applicator according to claim 1 , wherein the holding apparatus has an adhesive layer or a snap connection.7. A method for applying a ...

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Номер записи: 83
04-07-2013 дата публикации

DISPOSABLE INTRAMEDULLARY DEVICE FOR TEMPORARY USE FOR TREATMENT OF LIMB INFECTIONS

Номер: US20130172827A1
Автор: Guitelman Gustavo
Принадлежит: LABORATORIOS S.L. S.A.

A disposable intramedullary device for temporary use for treatment of limb infections comprising a solid core of variable cross-section, including a distal portion, a middle portion and a proximal portion, said proximal portion and distal portion including anchoring regions consisting of through-holes being passed through by bone anchoring means. Outside said anchoring regions, said solid core is coated with a polymer layer which also includes antibiotic, the outer diameter of the solid core and polymer layer assembly being equivalent to that of an intramedullary channel, and the outer diameter of said solid core in said anchoring regions being equivalent to that of a said intramedullary channel. 1. A disposable intramedullary device for temporary use for treatment of limb infections comprising a solid core of variable cross-section , including a distal portion , a middle portion and a proximal portion , the proximal portion and distal portion including anchoring regions consisting of through-holes being passed through by bone anchoring means , wherein , outside said anchoring regions , said solid core is coated with a polymer layer including antibiotic , the outer diameter of the solid core and polymer layer assembly being equivalent to that of an intramedullary channel , and the outer diameter of said solid core in said anchoring regions being equivalent to that of said intramedullary channel.2. The device according to claim 1 , wherein said polymer and antibiotic layer has a thickness up to 3 mm.3. The device according to claim 1 , wherein outside said anchoring regions claim 1 , the section of said core is circular.4. The device according to claim 1 , wherein said solid core is preferably helically surrounded by a solid element of small section to contribute to the integrity of the polymer and antibiotic layer arranged thereon.5. The device according to claim 4 , wherein the section of said solid element is circular and/or polygonal.6. The device according to ...

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Номер записи: 84
11-07-2013 дата публикации

ANTI-DESPR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY

Номер: US20130177500A1
Автор: Herrera Victoria L.M., Ruiz-Opaz Nelson
Принадлежит: Trustee of Boston University

Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anto-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo-non invasive imaging and/or assessments. 173-. (canceled)74. An isolated anti-DEspR antibody or antibody fragment thereof that specifically binds to human DEspR (dual endothelin/VEGF signal peptide receptor) expressed on a living cell , wherein the antibody , or antibody fragment thereof , is a composite fully human monoclonal antibody or antibody fragment thereof and wherein the antibody or antibody fragment thereof binds to a tumor cell.75. The anti-DEspR antibody or antibody fragment thereof of claim 74 , wherein the antibody or antibody fragment thereof specifically binds to residues 1-9 of SEQ ID NO:1.76. The anti-DEspR antibody or antibody fragment thereof of claim 74 , wherein the antibody or antibody fragment thereof comprises the complementarity determining regions (CDRs) of a variable heavy (V) chain amino acid sequence comprising a sequence of SEQ ID NO: 4 and the CDRs of a variable light (V) chain amino acid sequence comprising a sequence of SEQ ID NO: 9.77. A pharmaceutical composition comprising an isolated anti-DEspR antibody or antibody fragment thereof that specifically binds to human DEspR (dual endothelin/VEGF signal peptide receptor) expressed on a living cell claim 74 , wherein the antibody claim 74 , or antibody fragment thereof claim 74 , is a composite fully human monoclonal antibody or antibody fragment thereof and wherein the antibody or antibody fragment thereof binds to a tumor cell.78. A pharmaceutical ...

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Номер записи: 85
11-07-2013 дата публикации

Sharp Tip Carbon Nanotube Microneedle Devices and Their Fabrication

Номер: US20130178722A1
Автор: Aria Adrianus I., Gharib Morteza, Lyon Bradley
Принадлежит: California Institute of Technology

Carbon nanotube needles and needle arrays are described in which the precursor pillars are etched by oxygen plasma treatment to provide tapered and/or sharp-tip needles. Processes, products by process, and devices incorporating the sharp-tip needles are further described. 1. A method of sharp-tip carbon nanotube needle array fabrication , comprising:exposing a plurality of carbon nanotube pillars in an array to oxygen plasma treatment,wherein each pillar is etched into a needle format with a reduced diameter tip relative to a larger diameter base.2. The method of claim 1 , wherein the oxygen plasma treatment is continued until at least some of the needles have a tip diameter of about 10 μm or less.3. The method of claim 2 , wherein a diameter of the pillars before oxygen plasma treatment is at least about 25 μm.4. The method of claim 3 , wherein the pillar diameter before oxygen plasma treatment is about 50 μm.5. The method of claim 4 , wherein the tip diameter produced after oxygen plasma treatment is about 10 μm and the base diameter after oxygen plasma treatment is about 50 μm.6. The method of claim 4 , wherein the tip diameter produced after oxygen plasma treatment is about 5 μm.7. The method of claim 6 , wherein the tip has an outer diameter of 6 μm and an inner diameter of 4 μm.8. The method of claim 2 , wherein the tip diameter produced after oxygen plasma treatment is about 5 μm or less.9. The method of claim 8 , wherein the tip diameter produced after oxygen plasma treatment is about 1 μm or less.10. The method of claim 9 , wherein the tip diameter is about 800 nm.11. The method of claim 10 , wherein the tip includes a sub-micron size lumen.12. The method of claim 11 , wherein the tip includes no lumen.13. The method of claim 2 , wherein the tip includes no lumen.14. The method of claim 2 , wherein the oxygen plasma treatment is a remote treatment.15. The method of claim 14 , wherein the oxygen plasma treatment is dosed at a flow rate of 150 sccm claim 14 , ...

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Номер записи: 86
11-07-2013 дата публикации

Devices for transdermal drug delivery

Номер: US20130178830A1
Автор: Dewan Fazlul Hoque Chowdhury
Принадлежит: NDM Technologies Ltd

A transdermal drug delivery device comprises needles or other means for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. Means are provided for applying the carriers to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

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Номер записи: 87
11-07-2013 дата публикации

IDENTIFYING SYNTHETIC LIGANDS THAT BIND T-CELLS FROM PATIENTS HAVING AN AUTOIMMUNE DISEASE

Номер: US20130178835A1
Автор: Gocke Anne R., KODADEK THOMAS, Udugamasooriya D. Gomika
Принадлежит: The Board of Regents of the University of Texas System

The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations. 1. A method of identifying a ligand that is specifically recognized by autoimmune T cells comprising:(a) providing a first T cell population from a healthy subject, wherein said population is labeled with a first detectable label;(b) providing a second T cell population from a subject having an autoimmune disease, wherein said population is labeled with a second detectable label;(c) contacting said first and second T cell populations with a plurality of candidate ligands; and(d) assessing binding of said first and second T cell populations to said candidate ligands,wherein if said ligand binds to said second T cell population but not to said first T cell population, the said ligand is recognized by autoimmune but not healthy T cells.2. The method of claim 1 , wherein said autoimmune disease is multiple sclerosis or rheumatoid arthritis.3. The method of claim 1 , wherein said ligand is a 3-mer claim 1 , a 4-mer claim 1 , a 5-mer claim 1 , a 6-mer claim 1 , a 7-mer claim 1 , an 8-mer claim 1 , a 9-mer or a 10-mer.4. The method of claim 1 , wherein said first and second labels are fluorescent or chemiluminescent.5. The method of claim 1 , wherein said first and second labels are quantum dots.6. The method of claim 1 , wherein said ligand is bound to a support.7. The method of claim 6 , wherein said support is a bead claim 6 , a chip claim 6 , a filter claim 6 , a dipstick claim 6 , a membrane claim 6 , a polymer matrix or a well.8. The method of claim 7 , wherein contacting comprises bringing said support into contact with said first and second T cell populations at the same time.9. The method of claim 1 , wherein said T cell ...

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Номер записи: 88
25-07-2013 дата публикации

PATCH APPLYING APPARATUS

Номер: US20130190794A1
Автор: Ansaldo Alexander Bernard, Crichton Michael Lawrence, Falconer Robert John, Kendall Mark Anthony Fernance
Принадлежит: The University of Queensland

Apparatus for applying a patch to a subject, the patch having a number of projections thereon, the apparatus including opposable jaws movable between open and engaging positions, wherein in the open position the jaws can receive at least part of the subject, and in the engaging position the jaws can engage the at least part of the subject and a patch support for supporting a patch, and wherein the patch support is for urging the patch against the at least part of the subject. 1) Apparatus that when used applies a patch to a subject , the patch having a number of projections thereon , the apparatus including:a) opposable jaws that when used move between open and engaging positions, wherein in the open position the jaws can receive at least part of the subject, and in the engaging position the jaws can engage the at least part of the subject; and,b) a patch support that when used supports a patch, and wherein the patch support when used urges the patch against the at least part of the subject.2) Apparatus according to claim 1 , wherein the apparatus is for applying the patch to thereby at least partial control at least one application parameter.3) Apparatus according to claim 2 , wherein the at least one application parameter is controlled to thereby at least partially control a depth of penetration of the projections.4) Apparatus according to claim 2 , wherein the at least one application parameter includes at least one of:a) an application force; and,b) an application velocity.5) Apparatus according to claim 1 , wherein the apparatus is adapted to apply a patch at a velocity of at least 1 m/s.6) Apparatus according to claim 1 , wherein the apparatus includes a retaining system for retaining the jaws in the engaging position.7) Apparatus according to claim 1 , wherein the apparatus includes a biasing mechanism for urging the jaws towards the engaging position.8) Apparatus according to claim 7 , wherein the biasing mechanism is used to control application parameters.9 ...

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Номер записи: 89
01-08-2013 дата публикации

GRIPPING DEVICE AND METHOD OF USE THEREOF

Номер: US20130192028A1
Автор: Pierce Jai Dickenson
Принадлежит:

A gripping device is provided for gripping in a user's hand in use. The gripping device includes a body portion having a first end and a second end, and at least first, second and third digit location means defined in the body portion between said first and second ends for the location of at least part of a user's hand digit in use. The first digit location means is provided along the length of the body portion between the first and second ends. The at least second and third digit location means are provided either side of the first digit location means. 1. A gripping device for gripping in a user's hand in use , said gripping device comprising:a body portion having a first end and a second end and at least first, second and third digit location means defined in said body portion between said first and second ends for the location of at least part of a user's hand digit in use, and wherein the first digit location means is provided along the length of the body portion between the first and second ends, and the at least second and third digit location means are provided either side of the first digit location means.2. The gripping device of wherein the first digit location means is provided along substantially the entire length of the body portion between the first and second ends.3. The gripping device of wherein the first digit location means is of such dimensions and shape for location of at least part of a user's index finger therein in use claim 1 , the second digit location means is of such dimensions and shape for location of at least part of a user's thumb therein in use claim 1 , and the third digit location means is of such dimensions and shape for location of at least part of a user's middle finger therein in use.4. The gripping device of wherein a central plane claim 1 , axis or longitudinal axis of the first claim 1 , second and/or third digit location means is substantially non-linear.5. The gripping device of wherein the first claim 1 , second and/or ...

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Номер записи: 90
01-08-2013 дата публикации

SEALING APPARATUS FOR ANATOMICAL PART IN, E. G., CLOSED CHAMBER THERAPY

Номер: US20130192610A1
Автор: Gagnon Emilie, Jacques Jean-François, Lemieux Christian, McNabb Robert
Принадлежит:

A sealing apparatus for an anatomical part comprises a support collar that comprising an annular body. An elastic sealing membrane is positioned within the support collar. The sealing membrane defines an annular sealed chamber having a given inner diameter in a natural state of the elastic material. A port in the sealing apparatus is in fluid communication with the chamber. The port is adapted to be in fluid communication with a device for reducing pressure in the chamber to increase the given inner diameter of the chamber in a collapsed state, so that an anatomical part may be inserted into the sealing apparatus. A sealing apparatus and accessories are also provided, as is a method for sealing an anatomical part in an inner cavity of an accessory. 1. A sealing apparatus for an anatomical part , comprising:a support collar comprising an annular body;a sealing membrane of an elastic material positioned within the support collar to define an annular sealed chamber therewith having a given inner diameter in a natural state of the elastic material; anda port in the sealing apparatus in fluid communication with the annular sealed chamber, the port adapted to be in fluid communication with a device for reducing a pressure in the sealed chamber to increase said given inner diameter of the annular sealed chamber in a collapsed state for insertion of the anatomical part in the sealing apparatus.2. The sealing apparatus according to claim 1 , wherein the port comprises a throughbore in a wall in the annular body of the support collar.3. The sealing apparatus according to claim 1 , wherein the annular body of the support collar defines an inner annular cavity forming part of the annular sealed chamber with the sealing membrane.4. The sealing apparatus according to claim 1 , wherein the support collar has outer annular channels at opposite ends of the annular body claim 1 , the outer annular channels being connected to at least one of the sealing membrane and an accessory used ...

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Номер записи: 91
01-08-2013 дата публикации

Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques

Номер: US20130195828A1
Автор: Ameer Guillermo A., Kibbe Melina R., Varu Vinit N.
Принадлежит: Northwestern University

Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator. 1. A pharmaceutical composition comprising:(a) a mixture comprising each of collagenase type I, collagenase type III, collagenase type IV, and collagenase type V; and(b) a carrier.2. The pharmaceutical composition of claim 1 , wherein the collagenases are present in the composition at concentrations that are sufficient for digesting a human arterial plaque and reducing mass of the human arterial plaque by at least 30% after the sample is contacted with the composition for no more than about 30 minutes.3. The pharmaceutical composition of claim 1 , comprising each of collagenase type I claim 1 , collagenase type III claim 1 , collagenase type IV claim 1 , and collagenase type V at a concentration of at least 0.5 mg/ml.4. The pharmaceutical composition of claim 1 , wherein the mixture of consists of collagenase type I claim 1 , collagenase type III claim 1 , collagenase type IV claim 1 , and collagenase type V.5. The pharmaceutical composition of claim 1 , further comprising a cyclodextrin at a concentration of 5-25 mM.6. The pharmaceutical composition of claim 1 , further comprising a chelating agent at a concentration of 0.75-1.25 mg/ml.7. The pharmaceutical composition of claim 1 , further comprising tissue plasminogen activator at a concentration of 0.75-1.25 mg/ml.8. The pharmaceutical composition of claim 1 , further comprising cholesterol esterase at a concentration of 0.1-10 units/ml.9. The pharmaceutical composition of claim 1 , further comprising lipoprotein lipase at a concentration of 30-10 claim 1 ,000 units/ml.10. The pharmaceutical composition of claim 1 , further comprising apolipoprotein CII at a ...

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Номер записи: 92
01-08-2013 дата публикации

Devices and methods for selectively lysing cells

Номер: US20130197427A1
Автор: Adnan I. Merchant, Mark E. Deem
Принадлежит: Cabochon Aesthetics Inc

A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and at least one pressure sensor for measuring tissue apposition pressure, the pressure sensor being mounted on one of the housing and the needle array.

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Номер записи: 93
01-08-2013 дата публикации

METHODS AND SYSTEMS FOR DELIVERY OF LIVE CELLS

Номер: US20130197480A1
Автор: McDaniel David H.
Принадлежит: PALOMAR MEDICAL TECHNOLOGIES, INC.

Described herein are methods for delivering live cells into tissue, such as skin or other animal tissue, that has been treated with a laser (e.g. at a minimally coagulating setting) to produce voids/channels/grooves in the tissue. It has been surprisingly discovered that voids having a minimal coagulation zone around the ablation void provide a receptive environment into which live cells are readily delivered (without the need for injections into the target tissue) and can therefore survive and persist. 1. A method of delivery of at least one live animal cell into tissue comprising:ablating a portion of the tissue with electromagnetic radiation to form a plurality of voids extending to a depth below a surface of the tissue; anddelivering a live animal cell into one or more of the voids.2. The method of claim 1 , wherein delivering a live animal cell into the one or more voids comprises applying a composition comprising the cell onto the surface of the tissue.3. The method of claim 2 , wherein delivering the live animal cell comprises applying positive pressure to the surface of the tissue concurrently with or after applying the composition.4. The method of claim 1 , wherein conditions selected for ablating the portion of the tissue minimize the coagulation zone of tissue damage.5. The method of claim 1 , wherein at least a portion of the voids extend to a depth in a range of approximately 0.1 μm to 10 mm.6. The method of claim 1 , wherein at least a portion of the voids extend to a depth of approximately the dermal-epidermal border claim 1 , to a depth inside the dermal layer claim 1 , to a depth inside the epidermal layer claim 1 , to a depth inside the subcutaneous layer claim 1 , or to a depth deeper than the subcutaneous layer.7. The method of claim 1 , wherein the tissue is skin tissue and wherein the voids extend from the surface of the skin tissue to the epidermis.8. The method of claim 1 , wherein the tissue is skin tissue and wherein the voids extend from ...

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Номер записи: 94
08-08-2013 дата публикации

Use Of 2,5-Dihydroxybenzene Derivatives For Treating Actinic Keratosis

Номер: US20130202580A1
Автор: Cuevas Sànchez Pedro
Принадлежит: AmDerma Pharmaceuticals, LLC

The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, actinic keratosis. 2. The method of claim 1 , wherein Y is —SOH.34-. (canceled)6. (canceled)7. The method of claim 1 , wherein the compound of Formula (I) is selected from: 2-(acetyloxy)-5-hydroxybenzenesulfonic acid; 5-(acetyloxy)-2-hydroxybenzenesulfonic acid; and 2 claim 1 ,5-bis(acetyloxy)benzenesulfonic acid; or a pharmaceutically acceptable salt thereof.810-. (canceled)11. The method of claim 1 , wherein the actinic keratosis is selected from the group consisting of: hypertrophic claim 1 , atrophic claim 1 , bowenoid claim 1 , and acantholythic keratosis.12. The method of claim 1 , wherein the compound of Formula (I) is administered topically.13. The method of claim 1 , wherein the compound of Formula (I) is administered orally claim 1 , buccally claim 1 , transdermally claim 1 , by inhalation claim 1 , rectally claim 1 , or intravaginally.14. The method of claim 1 , further comprising administration of at least one additional therapeutic agent.15. The method of claim 14 , wherein the at least one additional therapeutic agent is selected from the group consisting of: imiquimod claim 14 , diclofenac claim 14 , glycidic acid claim 14 , trichloroacetic acid claim 14 , colchicine claim 14 , T4 endonuclease claim 14 , 5-fluorouracil claim 14 , isotretinoin claim 14 , acitretin claim 14 , cidofoir claim 14 , 5-aminolevulinic acid claim 14 , methyl aminolevulinate claim 14 , hypericin claim 14 , a chemotherapeutic agent claim 14 , a corticosteroid claim 14 , an antibiotic claim 14 , an analgesic claim 14 , an immunomodulator claim 14 , an immunosuppressant claim 14 , an anti-angiogenic claim 14 , a leukotriene modifier claim 14 , an aminosalicylate claim 14 , an anesthetic claim 14 , a non-steroidal anti-inflammatory claim 14 ...

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Номер записи: 95
08-08-2013 дата публикации

METHOD FOR CLEARING A BODY LUMEN ENVIRONMENT

Номер: US20130204086A1
Автор: GAT Daniel, Rabinovitz Elisha, Rosenthal Shirrie
Принадлежит: GIVEN IMAGING LTD.

An in vivo sensing device and system may contain or be used in conjunction with an image sensor and a body lumen clearing element or agent. A method may enable clearing a body lumen for in vivo sensing while using the device of the invention. 1. A method of using a lumen clearing element for the clearance of a body lumen , said method comprising:administering into a body lumen a composition containing a lumen clearing element, said lumen clearing element comprising an element selected from the group consisting of: a coagulant, a flocculant, an aggregant, or a combination thereof.2. The method according to claim 1 , wherein said step of administering a composition containing a lumen clearing element comprises administering the composition in two or more discrete dosage forms.3. The method according to claim 1 , wherein said lumen clearing element is in a form selected from the group consisting of: a tablet claim 1 , capsule claim 1 , lozenge claim 1 , powder claim 1 , granule claim 1 , caplet claim 1 , solution claim 1 , suspension claim 1 , emulsion claim 1 , or a combination thereof.4. The method according to claim 1 , wherein said method further comprises the step of administering a clear liquid diet claim 1 , prior to the step of administering the composition containing a lumen clearing element.5. The method according to claim 1 , wherein said method further comprises the step of inserting an in-vivo device into the body lumen claim 1 , following administering the composition containing a lumen clearing element.6. The method according to claim 4 , wherein said in-vivo device is selected from the group consisting of: a swallowable imaging capsule claim 4 , an endoscope claim 4 , a colonoscope and other intra luminal viewing and imaging devices.7. The method according to claim 1 , wherein said method further comprises the step of administering gut-lavage solutions.8. The method according to claim 1 , wherein said body lumen is the colon.9. The method according to ...

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Номер записи: 96
15-08-2013 дата публикации

Integrated device for orienting an object according to a given spatial orientation and method for manufacturing the same

Номер: US20130205761A1
Автор: Alexandre Girard, Geneviève Miron, Jean-Philippe Lucking-Bigue, Jean-Sébastien Plante, Patrick Chouinard, Sylvain Proulx
Принадлежит: SOCPRA Sciences et Genie SEC

There is disclosed an integrated device for orienting an object according to a given spatial orientation comprising a frame and a supporting member connected thereto and adapted for supporting a portion of the object. The integrated device comprises a plurality of fluid actuated devices integrally molded and joined together through a joining portion to form an integral unit for displacing the supporting member with respect to the frame. Each fluid actuated device is actuatable between a first position wherein the device has a first length and a second position wherein the device has a second length. The integrated device comprises an actuation mechanism for actuating each fluid actuated device between the first position and the second position to enable displacing the supporting member with respect to the frame, thereby orienting the object according to the given spatial orientation. The integrated device may be of particular interest in the medical sector as a medical object manipulator for reaching a given target in an anatomical structure. A manufacturing method is also provided.

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Номер записи: 97
15-08-2013 дата публикации

Micro-needle coating method

Номер: US20130209660A1
Автор: Hidetoshi Hamamoto, Katsunori Kobayashi, Takurou Kurita, Yuji Makino
Принадлежит: MedRx Co Ltd, Teijin Ltd

Since all methods of applying a drug liquid to a tip portion of a microneedle are application of the drug liquid in an open system, evaporation of the solvent from the drug liquid is unavoidable, such that the concentration of the drug liquid changes easily, and a large amount of the drug liquid is necessary. The invention provides a method of applying a drug to a pin-frog-shaped microneedle by using a small amount of the solution and without variation of the concentration of the drug liquid. A member having plural grooves is produced, and one end thereof is immersed in a drug liquid tank to fill the grooves with the drug liquid. The drug can be uniformly applied to a tip portion of the microneedle by setting the pin-frog-shaped microneedle to pass through the drug liquid in the grooves.

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Номер записи: 98
15-08-2013 дата публикации

ANTIBIOTIC DELIVERY SYSTEM FOR TREATING AN INFECTED SYNOVIAL JOINT DURING RE-IMPLANTATION OF AN ORTHOPEDIC PROSTHESIS

Номер: US20130211334A1
Автор: de Beaubien Brian C.
Принадлежит:

An antibiotic delivery system including an intramedullary stem that is adapted to be removably mounted into a medullary canal of a bone. The stem includes a body having an inlet adapted to be in fluid communication with a source of liquid-borne antibiotic and a plurality of outlets disposed along the stem. A channel extends between the inlet and the plurality of outlets for delivering a fluid-borne antibiotic from the inlet to the plurality of outlets so as to distribute the antibiotic along the medullary canal in a controlled fashion. 1. An antibiotic delivery system comprising:an intramedullary stem adapted to be removably mounted into a medullary canal of a bone, said intramedullary stem defining a body having a longitudinal axis, said body including a plurality of fins extending therealong and disposed in spaced angular relationship with respect to each other, said fins adapted to engage said medullary canal in a removably stable fashion, said stem including an inlet adapted to be in fluid communication with a source of fluid-borne antibiotic, a plurality of outlets disposed along said stem and between the outer surface of one of said plurality of adjacent fins and a channel extending between said inlet and said plurality of outlets for delivering fluid-borne antibiotic from said inlet to said plurality of outlets so as to distribute said antibiotic along the medullary canal in a controlled fashion.2. An antibiotic delivery system as set forth in claim 1 , wherein said fins include an irregular longitudinally extending outer surface that is adapted to engage the medullary canal and that allows the flow of fluid-borne antibiotic between said fins and said medullary canal.3. An antibiotic delivery system as set forth in claim 2 , wherein said irregular surfaces defines a plurality of serrations that present peaks and valleys whereby said peaks are in contact with the medullary canal and said valleys present openings through which fluid-borne antibiotic may pass.4. ...

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Номер записи: 99
15-08-2013 дата публикации

Antibiotic delivery system and method for treating an infected synovial joint during re-implantation of an orthopedic prosthesis

Номер: US20130211369A1
Автор: Brian C. de Beaubien
Принадлежит: Individual

An antibiotic delivery system including an intramedullary stem that is adapted to be removably mounted into a medullary canal of a bone. The stem includes a body having an inlet adapted to be in fluid communication with a source of liquid-borne antibiotic and a plurality of outlets disposed along the stem. A channel extends between the inlet and the plurality of outlets for delivering a fluid-borne antibiotic from the inlet to the plurality of outlets so as to distribute the antibiotic along the medullary canal in a controlled fashion. A method of treating an infected joint during a two-stage re-implantation of an orthopedic implant is also disclosed.

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Номер записи: 100