КОНТРОЛИРУЮЩЕЕ ПОТЕНЦИАЛ ТЕЛА ЧЕЛОВЕКА УСТРОЙСТВОДЛЯ ЭЛЕКТРОТЕРАПИИ

Изобретение относится к области медицинской техники. Устройство для электротерапии по первому варианту содержит секции источника питания, секции генерации импульсов, биполярные выходные секции и секцию контроля рабочего времени с функцией сигнализации. Секции источника питания предназначены для выработки высоковольтных сигналов с заданной частотой генерации, подаваемых на биполярные выходные секции после настройки частот генерации импульсов. Секции генерации импульсов предназначены для подачи заданного постоянного тока на другие секции устройства после выпрямления напряжения сети переменного тока при помощи моста. Биполярные выходные секции выполнены с возможностью выбора полюсов за счет операции переключения после усиления сигналов, поступающих с выхода секций генерации импульсов. Для каждого полюса предусмотрена секция источника питания и секция генерации импульсов. Каждая из выходных клемм биполярных выходных секций снабжена резистором и генератором треугольных импульсов для исключения ...

УСТРОЙСТВО ДЛЯ СТИМУЛЯЦИИ РЕГЕНЕРАЦИИ КОЖИ

Группа изобретений относится к медицине, а именно к устройству и косметическому способу стимуляции регенерации кожи посредством одновременного воздействия на кожу пациента электромагнитным полем, генерируемым емкостной радиочастотной системой, и электростимуляции кожи с помощью системы электростимуляции. Устройство содержит емкостную радиочастотную систему, систему электростимуляции кожи, логический блок, ручной блок. Радиочастотная система состоит из электронной схемы и генерирует электромагнитное поле. Указанная схема содержит источник переменного тока. Источник тока выполнен с возможностью генерирования сигнала с переменной частотой от 0,3 до 10 МГц и подключен к опорному ручному блоку, который должен держать пациент. Источник тока соединен с электродом с защитным покрытием для передачи к коже пациента электромагнитного поля. Система электростимуляции кожи состоит из электронной схемы. Указанная схема содержит генератор электростимуляции. Генератор выполнен для генерирования постоянного ...

МНОГОЧАСТОТНЫЙ ГЕНЕРАТОР ЭЛЕКТРИЧЕСКОГО ПОЛЯ И ЕГО ИСПОЛЬЗОВАНИЕ

Группа изобретений относится к области медицины. Устройство для лечения от патогенов в теле содержит пару электропроводных электродов, выполненных с возможностью электропроводного соединения с физически разнесенными точками на теле, и устройство генерирования сигнала. При этом устройство генерирования сигнала содержит средство генерирования сигнала для генерирования колебательного сигнала с выбранной частотой в диапазоне частот, причем этот диапазон частот может изменяться между первым уровнем частот в 5,4 МГц и вторым уровнем частот в 660 МГц, средство, обеспечивающее шаговое изменение частоты указанного средства генерирования сигнала от одного уровня частоты до другого из указанных уровней частоты с заданными шагами изменения частоты при поддержании каждого уровня частоты в течение заданного интервала времени, и средство передачи энергии, управляемое указанным средством генерирования сигнала, для подачи напряжения на указанные электроды, причем это напряжение колеблется с указанной выбранной ...

КАРТРИДЖ РАДИОЧАСТОТНОГО ЭЛЕКТРОДА ДЛЯ ПРОЦЕДУРЫ ПОДДЕРЖАНИЯ КРАСОТЫ КОЖИ И ИСПОЛЬЗУЮЩИЙ ЕГО РУЧНОЙ БЛОК ДЛЯ ПРОЦЕДУРЫ ПОДДЕРЖАНИЯ КРАСОТЫ КОЖИ

Изобретение относится к медицине. Предложен картридж радиочастотного электрода для процедуры ухода за кожей и снабженный им ручной блок для процедуры ухода за кожей. Картридж радиочастотного электрода для процедуры ухода за кожей содержит корпус картриджа и тело радиочастотного электрода, контактирующее с кожей для подачи радиочастотной энергии внутрь кожи, корпус картриджа включает в себя: первую часть корпуса и вторую часть корпуса, шаровую шарнирную часть, соединяющую первую часть корпуса и вторую часть корпуса, что позволяет свободно наклонять первую часть корпуса во всех диапазонах 360 угловых градусов в пределах радиуса первой части корпуса, и сильфонный элемент, имеющий одну концевую часть, соединенную с первой частью корпуса, и противоположную концевую часть, соединенную со второй частью корпуса, расположенный так, чтобы окружать шаровую шарнирную часть, и снабженный гофрированными частями. Ручной блок для процедуры ухода за кожей, содержит картридж радиочастотного электрода, включающий ...

МНОГОЧАСТОТНЫЙ ГЕНЕРАТОР ЭЛЕКТРИЧЕСКОГО ПОЛЯ И ЕГО ИСПОЛЬЗОВАНИЕ

... 1. Устройство для лечения от патогенов в теле, содержащее: по меньшей мере, пару электропроводных электродов, выполненных с возможностью электропроводного соединения с физически разнесенными точками на теле; и устройство генерирования сигнала, содержащее: средство генерирования сигнала для генерирования колебательного сигнала с выбранной частотой в некотором диапазоне частот, причем этот диапазон частот может изменяться между первым уровнем частоты и вторым уровнем частоты, причем второй уровень частоты больше, чем 1,0 МГц; средство, обеспечивающее шаговое изменение частоты указанного средства генерирования сигнала от одного уровня частоты до другого из указанных уровней частоты с заданными шагами изменениями частоты, при поддержании каждого уровня частоты в течение заданного интервала времени; и средство передачи энергии, управляемое указанным средством генерирования сигнала, для подачи напряжения на указанные электроды, причем это напряжение колеблется с указанной выбранной частотой.

УСТРОЙСТВО ОТ УКАЧИВАНИЯ

... 1. Устройство с электрическим приводом, содержащее вставной компонент для вставления в полость уха пользователя, устройство содержит, по меньшей мере, один индуктор функционально связанный со схемой управления, схема управления предоставляет электрическую энергию, по меньшей мере, на один индуктор, при этом вставной компонент содержит, по меньшей мере, один индуктор такой, чтобы при использовании, по меньшей мере, один индуктор находился в непосредственной близости от внутреннего уха пользователя. ! 2. Устройство с электрическим приводом по п.1, в котором схема управления контролирует подачу электрической энергии, по меньшей мере, на один индуктор, так чтобы электрическая энергия подавалась импульсами. ! 3. Устройство с электрическим приводом по п.1, в котором схема управления содержит средства регулировки, управляемые пользователем, средства регулировки контролируют подачу электрической энергии, по меньшей мере, на один индуктор. ! 4. Устройство с электрическим приводом по п.3, в котором ...

УСТРОЙСТВО И СПОСОБ ДЛЯ ЗАЖИВЛЕНИЯ И ВОССТАНОВЛЕНИЯ ТКАНЕЙ СЕРДЦА И ДЛЯ ЭЛЕКТРОФИЗИОЛОГИЧЕСКОЙ, МЕТАБОЛИЧЕСКОЙ ОПТИМИЗАЦИИ СЕРДЦА

Generator zur Erzeugung von elektromagnetischen Wellen

Vorrichtung zum Stimulieren des Gehirns einer Person

Vorrichtung zum Stimulieren des Gehirns (3B) einer Person (2), Folgendes umfassend: (a) einen Detektor (10) zum Erfassen eines induzierten oder eines vom Gehirn (3B) erzeugten spontanen physiologischen Signals; (b) eine Steuereinheit (12), die an den Detektor (10) angeschlossen ist, um das erfasste physiologische Signal mit einem Kriterium zu vergleichen, um eine optimale Einstellung eines variablen Signalparameters zu bestimmen; (c) einen Signalgeber (8) zum Anlegen eines elektrischen Stimulationssignals (ESS) an die Person (2), wobei mindestens ein Signalparameter des Stimulationssignals (ESS) durch schrittweises Annähern auf einen Optimalwert ermittelt und in einem für die Person angelegten Speicher oder Speicherbereich abgelegt wird.

VORRICHTUNG ZUR BEHANDLUNG VON TUMOREN

VORRICHTUNG ZUR BEHANDLUNG VON TUMOREN

Elektrodenanordnung für ein behindertes Plasma

Eine Elektrodenanordnung zur Ausbildung eines dielektrisch behinderten Plasmas zwischen einer Wirkfläche (10) der Elektrodenanordnung und einer als Gegenelektrode fungierenden Oberfläche, mit einer flexiblen, flächigen Elektrode (8), die mit einer Hochspannungsquelle (28) verbindbar ist und mit einem flächigen, flexiblen und die Wirkfläche (10) bildenden Dielektrikum (9), das mit der flächigen Elektrode (8) zu einem Elektrodenelement (7) verbunden ist und die Elektrode (8) zur zu behandelnden Oberfläche hin vollständig abdeckt, weist eine verbesserte Anpassbarkeit an unregelmäßige Oberflächen auf durch ein flächenelastisches Andruckmittel (4) zum Andruck auf der der Oberfläche abgewandten Rückseite des Elektrodenelements (7) derart, dass das Elektrodenelement (7) unter lokaler Verformung an Unregelmäßigkeiten der Oberfläche selbsttätig anpassbar ist.

Stimulationssystem zur Therapie mit gepulsten elektromagnetischen Feldern mit einem zweiphasigen Spulenstrom

VORRICHTUNG ZUR ELEKTROMAGNETISCHEN THERAPIE

KATHETER ZUR ABLATION MITTELS HOCHFREQUENZ

Elektrofeld-Therapievorrichtung

Einrichtung zur Erzeugung schneller elektrischer Schwingungen

Electronic bioradiation apparatus for treating a patient with radiation with input signals from an oscillating module

The apparatus has a main device (10,4,5,6) and a bed or table (1). At least one transmitter coil (2,3) is positioned at the head or foot end of the bed. The energy for the emitted oscillations is transmitted from an amplifier (4) whose input signal comes from an oscillating module (5,6).

Selectable resonant frequency transcutaneous energy transfer system

APPLICATOR HEAD FOR ELECTROMAGNETIC TREATMENT

Improvements in apparatus for medical treatment with electrical oscillations of very high frequency

... 419,136. Generating high-frequency oscillations. SIEMENS & HALSKE AKT.- GES., Siemensstadt, Berlin. March 1, 1933, No. 6278. Convention date, March 30, 1932. [Class 40 (v).] An apparatus for medical treatment with electric oscillations comprises a generator circuit generating oscillations of over 10<7> periods per second, a treatment circuit and a separate closed electric oscillation circuit between the generator and treatment circuits. The construction illustrated consists of a generator circuit 2 in a housing 1, an intermediate circuit 6 consisting of inductances 7 and 8 and a variable condenser 9 and a treatment circuit consisting of an inductance 5, a tuning condenser 4 and a treatment condenser 3. Specification 390,247 is referred to. The Specification as open to inspection under Sect. 91 comprises also the use of a non- syntonizing intermediate circuit which preferably has a natural wave length situated within the frequency range employed. The non-syntonizing circuit may consist of ...

Improvements in and relating to methods and systems of treating products with electrical currents or fields to produce more valuable products

Alterations in biological processes are produced by treating substances with an electric field of above 20 volts per centimetre strength in pulses of less than 5m seconds so that the said field does not produce secondary processes to a detrimental extent either directly or indirectly by heating or by electrolysis. The field direction is alternated to prevent electrolysis and may be attained by two current impulses following quickly upon each other in opposite directions or by a condenser being charged and then discharged through the substance. An alternating current of rectangular shape or a modulated high-frequency alternating current is used and the fields may pass through the substance in different directions at right angles to each other. When a liquid is treated it may be led between a pair of electrodes giving a current in one direction then led through another pair of electrodes giving a current in the opposite direction, and cooling of the liquid may be effected between the pairs ...

ELECTRIC FIELD THERAPEUTIC APPARATUS

A PORTABLE BATTERY POWERED ELECTROMAGNETIC THERAPY APPLICATOR

Apparatus and methods for the transdermal delivery of active agents

A transdermal delivery system (1) configured to deliver an active agent to human or animal tissue, comprising a penetrative electrode (2) of one polarity that provides an electrical contact (3) beneath the stratum corneum (20); a surface electrode (4) of the opposite polarisation to that of the penetrative electrode (2) that provides an electrical contact to the external surface of the skin (21) on the opposite side of the stratum corneum (20) to the electrical contact (3) of the penetrative electrode (2); a dispenser (5) configured to deliver of an active agent to the external surface of the skin (21) adjacent to an electrical contact of the surface electrode (4); a method of delivering the active agent to the tissue of a human or animal body using the transdermal delivery system (1) and an electrode assembly (10) for use in preparing the transdermal delivery system (1).

Therapeutic apparatus for treatment of living tissue

Plasma coagulating electrosurgical instrument and electrosurgical apparatus incorporating the same

HIGH FREQUENCY ELECTROMAGNETIC FIELD

A ciliated stent-like system

Improvement with the senders of high frequency electromagnetic waves.

Energetic vibration information transmitting device, for energetic stimulation of organism and for energeticion of e.g. food, has energetic medium with vibration information that is transmitted to user by magnetic field produced by magnet

The device has an energetic informed medium connected with the permanent magnet (1) and designed in the form of a foil (2) that is made of plastic and metal, and a metallic wire. The foil is composed of a polyimide and the wire is composed of a metal alloy with a gold ratio of over 50%. Vibration information stored in the medium is transmitted to a user by magnetic field produced by the magnet.

ELECTRICAL MARK NAIL SYSTEM

MECHANISM FOR EXAMINING BIOLOGICAL KOERPER WITH ELECTROMAGNETIC FIELDS

AUXILIARY DEVICE FOR CONVERTING A CONVENTIONAL OSTEOSYNTHESIS IMPLANT INTO AN ELECTRICAL OSTEOSYNTHESIS IMPLANT

DEVICE FOR THE GENERATION OF ELECTRICAL ONE, MAGNETIC ONE AND/OR PULSATING ELECTROMAGNETIC FIELD

DEVICE FOR TREATING LIVING FABRICS AND/OR CELLS

Mechanism to the high frequency therapy

VORRICHTUNG ZUR ÜBERTRAGUNG ENERGETISCHER SCHWINGUNGSINFORMATIONEN

VORRICHTUNG ZUM BEHANDELN VON LEBENDEN GEWEBEN UND/ODER ZELLEN

ELECTRICALMEDICAL EQUIPMENT

STIMULATION SYSTEM TO THE THERAPY WITH PULSED ELECTROMAGNETIC FIELDS WITH A TWO-PHASE COIL STREAM

IMPROVED DEVICE FOR THE TREATMENT OF MEANS OF PULSATING ELECTROMAGNETIC ENERGY

ELEKTROMEDIZINISCHES GERÄT

The device comprises an oscillator (1) for the creation of an electromagnet field. The frequency and the duration of the treatment is determined by a control device (2) using the information from a particular program (3). The number of treatments given are counted by a special unit (4) activated simultaneously to the oscillator (1). The information about the duration of the treatment and its success is processed by an evaluation device (6) and displayed (7) for being used by the therapist for planning further treatments.

GERAT ZUR FORDERUNG VON HEILUNGSPROZESSEN

ELECTROMAGNETIC THERAPY EQUIPMENT

ELEKTROMAGNETOTHERAPIEGERÄT.

DEVICE FOR ENDOMETRIALEN ABLATION

EQUIPMENT FOR THE TREATMENT OF NEUROVEGETATIVE DISTURBANCES.

EQUIPMENT FOR ABLATION WITH BF

ELECTRODES FOR THE PRODUCTION OF CERTAIN SAMPLES OF PATHOLOGICALLY CHANGED FABRIC

COIL AND/OR GROUP OF COILS FOR THE TREATMENT OF A KORPERTEILES MEANS OF A LOW-FREQUENCY MAGNETIC ALTERNATING FIELD

ASYMETRI TRANSMISSION SYSTEM FOR RADIO-ELECTRICAL THERAPY

Short wave treatment electrode

GENERATOR FOR ELECTROMAGNETIC WAVES FOR MEDICAL APPLICATIONS

MONOPOLY-ACRE/BIPOLAR DEVICE FOR ENDOMETRIALEN ABLATION

MEDICAL PROBE WITH MECHANISM FOR OPTICAL OBSERVATION

GENERATOR FOR THE PRODUCTION OF ELECTROMAGNETIC WAVES

Kit and method for topical delivery of benefits

A system for delivering energy to an isolated part of a mammalian body includes an electrically powered patch and a self-supporting adhesive film. The patch has a major surface and comprises a matrix of at least one flexible, biocompatible material which is capable of conforming to the isolated body part. The self-supporting adhesive film has a first non-tacky surface arranged and configured for releasable attachment to the patch and a second tacky surface, opposite the first surface, for adhesive attachment to the isolated body part. The releasable attachment between the self-supporting adhesive film and the electrically powered patch has a lower strength than the adhesive attachment between the film and the isolated body part. Thus, during use the electrically powered patch is removable from the self-supporting adhesive film while leaving the self-supporting adhesive film adhered to the isolated body part.

High-voltage analog circuit pulser with feedback control

A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.

Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields

APPARATUS AND METHOD FOR TREATING MULTIPLE TUMORS IN PATIENTS WITH METASTATIC DISEASE BY ELECTRIC FIELDS An insulated electrode sys-tem for delivering a plurality of tumor treating electromagnetic fields including an array of electrode elements for proximate location on a body of a patient. Each electrode ele-ment of the array having an insulation layer. Each electrode element being independently electrically accessible and configured to be dynamically assigned to emanate an electro-magnetic field relative to at least one other of said electrode elements.

Mouthpiece apparatus for intraoral therapy and related system and method

Adjustable mouthpiece apparatuses for intraoral therapy are provided. The mouthpiece apparatus may comprise at least one emitting element to emit at least one therapeutic emission. In some embodiments, the mouthpiece apparatus comprises an upper panel and a lower panel and at least one adjustable connector interconnecting the upper panel and the lower panel and adjustable to change the spacing between the upper panel and the lower panel. The mouthpiece apparatus may thereby be adjusted for a range of vestibular heights. Also provided are related systems including adjustable mouthpiece apparatuses and related methods for making an adjustable mouthpiece apparatus.

Electrode for electrosurgical ablation of tissue

Regulation of transforming growth factor-beta (TGF-beta) gene expression in living cells via the application of specific and selective electric and electromagnetic fields

Bone repair enhancer

Electrical intramedullary nail system

Electromagnetic field stimulator device for anatomic biophysical chondroprotection

Medical probe device with optic viewing capability

METHOD AND APPARATUS FOR ELECTROMAGNETIC STIMULATION OF NERVE, MUSCLE, AND BODY TISSUES

IN-STENT RESTENOSIS DETECTION DEVICE

Intervertebral decompression

Intervertebral decompression

Methods and devices for stimulating an immune response using nanosecond pulsed electric fields

Coil device for use in transcranial magnetic stimulation device

The present invention provides a coil device for use in a transcranial magnetic stimulation device, and capable of increasing the strength of the electric field on a head surface. Thus, a coil device for use in a transcranial magnetic stimulation device that positions a wound coil on or near a head surface, and stimulates neurons by producing an electric current from an induced electric field in a magnetic stimulation target region inside the brain as a result of electromagnetic induction, wherein: the wound coil is equipped with a near-head-surface conductive wire section positioned on or near the head surface, and a far-head-surface conductive wire section positioned farther from the head surface than is the near-head-surface conductive wire section; and the distance between the near-head-surface conductive wire section and the far-head-surface conductive wire section is set so as to change in a manner such that the strength of the induced electric field increases in comparison to the ...

Nanoelectroablation control and vaccination

Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.

Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields

An insulated electrode system for delivering a plurality of tumor treating electromagnetic fields including an array of electrode elements for proximate location on a body of a patient. Each electrode element of the array having an insulation layer. Each electrode element being independently electrically accessible and configured to be dynamically assigned to emanate an electromagnetic field relative to at least one other of said electrode elements.

THERAPEUTIC APPARATUS USING SUPERPOSED AC & DC FIELD

Hair regrowth method and apparatus

Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient

DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably ...

Devices for therapeutic nasal neuromodulation and associated methods and systems

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Mapping catheter

Cardiac tissue ablation device

Adaptive electric field modulation of neural systems

Method to detect and electrosurgically treat aberrant myoelectric activity

PHOTODYNAMIC STIMULATION DEVICE AND METHODS

A treatment device which uses a light radiation of multiple wavelengths and pulse-shaped electromagnetic fields for the photodynamic stimulation of cells, especially cells of human tissue, and also for the activation and stimulation of light sensitive substances (PTD). The device produces energy radiation by the use of semiconductor and/or laser diodes, which emit light in several separate wavelengths due to a special operation mode and the use of tuneable diodes. The equipment consists of a stand, with which machine applicators are connected via a jointed arm. The stand is freely moveable on wheels and includes a control mechanism whereby the various parameters for therapy can be adjusted and switched on and off. The stand is also connected to a hand applicator for treatment of small tissue-areas, e.g., acupuncture points. Photodynamic substances are introduced into the tissue with a special hand applicator.

METHOD FOR ENERGY-BASED STIMULATION OF ACUPUNCTURE MERIDIANS

According to an aspect of the present disclosure, a method of weight loss involving acupuncture includes the steps of placing a plurality of EBS acupuncture needles at a plurality of predetermined locations of the body corresponding to acupuncture meridians; and energizing each of the plurality of EBS acupuncture needles to treat the body at the location of the EBS needle insertion.

MULTIPORTAL RADIO FREQUENCY GENERATOR

MULTI-PORTAL RADIO FREQUENCY GENERATOR A unique apparatus for multi-portal administration of radio frequency range electromagnetic energy for therapeutic treatment of interior portions of various substrates including animals and humans which comprises an R.F. signal generator which is connected to a timer component having switching logic to apply R.F. electromagnetic energy one set at a time, sequentially across a plurality of sets of paired electrode plates, i.e., applicators. Each set of paired electrode plates is positioned on a different axis with reference to a fixed central point located between the plates at which such axes approximately intersect and which is the location of the portion to be treated. The apparatus permits a fixed target, i.e., portion to be treated, to receive a constant input of R.F. energy although such energy is coming from different directions and emanating from different electrodes, hence several R.F. fields are created sequentially by the control mechanism ...

ATHERMAPEUTIC APPARATUS

METHOD AND DEVICE FOR TREATING OSTEOARTHRITIS AND CARTILAGE DISEASE, DEFECTS, AND INJURIES IN THE HUMAN HIP

A method of determining the voltage and current required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffold, growth factors, etc.) for treating cartilage defects in the human hip joint and a device for delivering such signals to a patient's hip. Anatomic, analytical, and planar circuit models are developed to determine the impedances, conductivities, and current flows in the human hip joint and its surrounding soft tissues and skin that are required to produce a 20mV/cm electric field in the synovium and articular cartilage of the human hip. The voltage of the signal applied to the surface electrodes (20) or to a coil(s) or solenoid is varied based on the size of the hip joint; larger hip joints require larger voltages to generate the effective electric ...

APPARATUS FOR PRODUCING COLLAGENIC MATERIAL FOR THE CLOSURE OF LESIONS

SWITCHED ELECTRICAL APPARATUS FOR MEDICAL USE

REGULATION OF ENDOCRINE AND EXOCRINE GLANDS BY MEANS OF NEURO-ELECTRICAL CODED SIGNALS

A method and device for endocrine and exocrine gland control. The method comprises selecting neuro-electrical coded signals from a storage area that are representative of body organ function. The selected neuro-electrical coded signals are then transmitted to a treatment member, which is in direct contact with the body, and which then broadcasts the neuro-electrical coded signals to a specific endocrine and exocrine gland nerve or gland to modulate the gland functioning. A control module is provided for transmission to the treatment member. The control module contains the neuro-electrical coded signals which are selected and transmitted to the treatment member, and computer storage can be provided for greater storage capacity and manipulation of the neuro- electrical coded signals.

PRECISION DELIVERY OF ENERGY UTILIZING HOLOGRAPHIC ENERGY TELEPORTATION (HET) WITH TIME-CORRELATED STANDING-WAVE INTERFERENCE AND COHERENT INTENSITY AMPLIFICATION

By producing the proper wave interference using superimposed waves that overlap with the proper time-phase relationship (called "Time-Correlated Standing-wave Interference"), wave energy is amplified (by "Coherent Intensity Amplification") and teleported to precise locations. For instance, in one application, energy is teleported to one or more areas within a living body for such therapeutic applications as destroying cancer cells or plaques within arteries. A system implementing this technique creates amplified constructive interference at one or more selected disease locations, while producing destructive interference at surrounding locations. In this application example, the technique allows energy to be "teleported" to tumor cells, plaques, or other diseased cells, for instance, to destroy them, while surrounding healthy cells receive virtually no energy, obviating collateral damage from the treatment. The same method can be used to diagnose disease by detecting energy teleported to ...

TISSUE-STIMULATING METHOD USING SPATIAL SCANNING OF ELECTRIC AND MAGNETIC FIELDS

This disclosure refers to methods and devices for electromagnetic stimulation of tissues. Some methods comprising the steps: a) disposing an arrangement of electromagnetic transducers encompassing a volume containing a tissue; b) applying an electromagnetic field stimulus to a tissue through the arrangement of electromagnetic transducers according to an activation pattern for a period of time; wherein the activation pattern allows to vary the intensity and direction of the electromagnetic field vector. Some devices comprising: a computing unit, an external power source connected to the computing unit; a decoupling circuit connected to the external power source and to the computing unit; a switching circuit connected to the external power source, to the decoupling circuit and to the computing unit; an arrangement of electromagnetic transducers connected to the computing unit and to the de switching circuit; wherein the computing unit implements the methods of the disclosure for electromagnetic ...

HIGH-VOLTAGE ANALOG CIRCUIT PULSER WITH FEEDBACK CONTROL

DEVICE FOR THE TREATMENT OF ARTHRITIS AND ARTHROSIS OF THE EXTREMITIES, CHRONIC INFLAMMATIONS, PAIN REDUCTION AND MUSCLE TENSION

The invention relates to a device for treating arthritis and osteoarthritis in extremities, which has the general form of a sheath in the form of a glove or sock comprising: an porous, inner fabric layer (14); a second layer in the manner of a paraffin-filled bladder (1) that covers the entire inner space, the inner paraffin layer (1) being surrounded by a Teflon splint (2) provided with means for straightening the fingers (nitonol wires or similar), followed by a very thin layer of latex or insulating material (4), and lastly an outer covering (6). Complementarily, the device can comprise wires or resistors (5) around each finger or parallel to the palm or back of the hand. Additionally, the device comprises a control unit (12) for activation and for controlling the temperature and currents to be applied.

TTFIELD TREATMENT WITH OPTIMIZATION OF ELECTRODE POSITIONS ON THE HEAD BASED ON MRI-BASED CONDUCTIVITY MEASUREMENTS

When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by obtaining electrical conductivity measurements in an anatomic volume and generating a 3D map of the conductivity directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types. A location of the target tissue is identified within the anatomic volume, and the positions for the electrodes are determined based on the 3D map of electrical conductivity and the position of the target tissue.

DUAL DOUBLE HELIX CONDUCTORS USED IN AGRICULTURE

A system including one or more bodies having an underlying structure resembling a double helix may be arranged and used, to produce useful electromagnetic effects for various agricultural applications, including promotion of growth in organisms and organic matter.

KIT AND METHOD FOR TOPICAL DELIVERY OF BENEFITS

A system for delivering energy to an isolated part of a mammalian body includes an electrically powered patch and a self-supporting adhesive film. The patch has a major surface and comprises a matrix of at least one flexible, biocompatible material which is capable of conforming to the isolated body part. The self-supporting adhesive film has a first non-tacky surface arranged and configured for releasable attachment to the patch and a second tacky surface, opposite the first surface, for adhesive attachment to the isolated body part. The releasable attachment between the self-supporting adhesive film and the electrically powered patch has a lower strength than the adhesive attachment between the film and the isolated body part. Thus, during use the electrically powered patch is removable from the self-supporting adhesive film while leaving the self-supporting adhesive film adhered to the isolated body part.

Device and method for treating cells

The present invention relates to a device for treating biological cells in an object, the device comprising: —a single winding coil element; —an electrical generator connected to the single winding coil element, the single winding being configured to be positioned essentially around the object; wherein the electrical generator is configured to discharge into the single winding coil element so that the single winding coil element generates a short duration pulsed electromagnetic field by magnetic induction in the single winding coil element, the electromagnetic field having a field strength that is sufficiently high to affect, preferably increase the permeability of cell membranes and/or intracellular membranes of the biological cells contained in the object when in operation the object is placed inside the single winding coil element.

Arrangement and method for influencing and/or detecting magnetic particles

The present invention relates to an arrangement and a method for influencing and/or detecting magnetic particles in a region of action, in particular for monitoring of intra-cerebral or intra-cranial bleeding using Magnetic Particle Imaging (MPI). A common coupling unit per coil of a coil array is provided for coupling all signals for generating the magnetic fields to the set of common coils. Further, the same coils are used for acquiring detection signals. In this way a small scanner can be built that can be left permanently or can be provided periodically to the patient, in particular for bleeding monitoring.

Radiofrequency hyperthermia device with target feedback signal modulation

The present invention relates to a radiofrequency (RF) hyperthermia device for capacitive coupling comprising a radiofrequency source, an amplifier, a sensor, a feedback amplifier and a modulation signal generator, wherein the radiofrequency source produces a source signal which is modulated by the modulation signal generator, amplified by the amplifier and directed to a target, the sensor receives a feed back signal from the target that is directed to the feed back amplifier, wherein the feedback signal is amplified by the feedback amplifier and modulates the source signal to generate a target modified signal. This radiofrequency (RF) hyperthermia device is designed for increasing the selectivity of the hyperthermia treatment.

Handheld excitation terminal and emf emitter providing dynamic optimization of emission and therapeutic effect and remote therapeutic system

A cell excitation terminal and a therapeutic system using customized electromagnetic (EM) waves varying dynamically with time for excitation include one or more EM wave generators, each of the EM wave generators is connected to a central processing unit (CPU), and the CPU controls, according to a signal detected by a human body status detection device, the EM wave generator to send EM waves corresponding to a detected status or subject patient. The therapeutic system can perform remote management. A remote server optimizes and updates therapeutic waveforms of a patient constantly according to a therapeutic effect of the patient, thereby improving the therapeutic effect constantly.

Regulation of stem cell gene production with specific and selective electric and electromagnetic fields

Methods and devices are described for the regulation of BMP 2 and 4, TGF-beta 1, 2, and 3, FGF-2, osteocalcin, and alkaline phosphatase mRNA in stem cells via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues containing the stem cells, where the specific and selective fields are generated by application of specific and selective signals to field generating devices disposed with respect to the stem cells so as to facilitate the treatment of diseased or injured bone and other tissues. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and/or other conditions in which BMP 2 and 4, TGF-beta 1, 2, and 3, FGF-2, osteocalcin, and alkaline phosphatase mRNA and/or protein deficiencies in stem cells has been implicated.

System for defining energy field characteristics to illuminate nano-particles used to treat invasive agents

The Invasive Agent Treatment System incorporates the pairing of energy fields with nano-particles to cause a thermal effect in the nano-particles, which thermal effect is transmitted into the biological cells of the invasive agent. The energy fields are derived from at least one or a combination of the following: an electric field, a magnetic field, an electromagnetic field (EM), an acoustic field, and an optical field. The Invasive Agent Treatment System provides the necessary coordination among the characteristics of the nano-particles, concentration of nano-particles, duration of treatment, and applied fields to enable the generation of precisely crafted fields and their application in a mode and manner to be effective with a high degree of accuracy.

Low temperature hyperthermia system for therapeutic treatment of invasive agents

The Low Temperature Hyperthermia System illuminates nano-particles, which are implanted in a living organism at the locus of the cancer or into the cancer cells, with a precisely determined energy field. This energy field ensures that the optimal cancer cell and cancer stem cell destruction temperature of 42° C. is not exceeded in the tissue, which minimizes the release of Heat Shock Proteins and cancer stem cells. The Low Temperature Hyperthermia System uses specially designed nano-particles that exhibit a specific temperature rise in a given illumination energy field and then have no further temperature rise even if the applied illumination energy field increases beyond the optimal level. Alternatively, the nano-particles exhibit a tightly controlled temperature rise based on a pre-determined illumination energy field strength. This innovative approach can also use radiation and/or chemotherapy in conjunction with the nano-particle illumination to kill the majority of the cancer cells.

Personal Item with Energy Enhancement Arrangement

A personal item includes a body being carried by a user and a plurality of different energy elements secured in the body. The energy elements are selected from a group consisting of hologram element, germanium, titanium, and an element carrying negative ions for generating a particular magnetic force which helps rebalance and restore natural energy pathways of the user. So, when the user carries the body, the energy elements are held close enough to the user in order to react positively with the user's energy field. Therefore, the personal item of the present invention is able to improve the blood circulation, recovery time, flexibility, strength, balance, healing and energy as well as contributing to an overall sense of health and well being among its users.

Wound care method and system with one or both of vacuum-light therapy and thermally augmented oxygenation

A combination therapy pad that includes a first layer and a second layer operatively coupled to the first layer. A fiber-optic array is disposed between the first layer and the second layer. A third layer is operatively coupled to the first layer. The third layer includes a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source. The third layer provides at least one of vacuum therapy and therapeutic fluid treatment to a wound area.

Systems and Methods to Reduce Power Deposition in Tissue Exposed to Radio Frequency Electromagnetic Fields

An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume.

Method and apparatus for providing complex tissue stimulation patterns

The invention relates to a stimulation device for creating complex or multi-purpose tissue stimulation. Many typical stimulation devices suffer from deficiencies in providing complex stimulation patterns. Using a circuitry operable or programmable to repeat and skip stimulation settings, a complex stimulation set may be created. The repeating and skipping functionality may be implemented in hardware or software. In this manner, complex stimulations may be derived from simple circuitries. Furthermore, these stimulations may be used to treat pain, stimulate bone growth, and control motor disorders, among others.

Dissection handpiece and method for reducing the appearance of cellulite

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Apparatus and Method for Heating Biological Targets

An apparatus and method for selectively heating a biological target within a treatment region of a subject is disclosed. The method includes administering to the subject a dielectric heating modulator that becomes associated with the biological target. The method also includes positioning the treatment region between first and second electrodes connected to a generator, and activating the generator to apply an alternating electric field between the first and second electrodes and across the treatment region to thereby heat the treatment region. The dielectric heating modulator causes the biological target to heat at a faster rate than non-targets within the treatment region, which preferably results in the killing of the biological target.

Device for non-thermal, electrically-induced closure of blood vessels by occlusion

Devices for the non-thermal, electrically-induced temporary or permanent closure of blood vessels. The subject devices employ pulsed electrical energy according to a defined regime to effect controlled occlusion of targeted blood vessels without hating the vessel and with minimal damage to adjacent tissue. The extent of vessel closure, i.e., temporary (vasoconstriction) or permanent (thrombosis), is controlled based on the manipulation of various parameters of the electrical stimulation regime as well as the configuration of the electrodes used to apply the regime.

METHOD AND SYSTEM FOR GENERATING PHYSIOLOGICAL SIGNALS WITH FABRIC CAPACITIVE SENSORS

A system for generating physiological signals using a cloth capacitive sensor, includes a cloth, at least one conductive area arranged on the cloth, a signal circuit; a capacitive sensor formed between the cloth and a human body; a resistor R, a capacitor C, an inductor L, an operational amplifier, a diode, a Schmitt trigger, CMOS, a transistor, or an IC, connected with the cloth capacitive sensor to form a charge and discharge circuit to change a signal range of frequency, cycle, voltage or current; wherein when a force, pressure, tensile force, torsion or tension is applied between the human body and the cloth, the capacitance changes, the circuit sends a signal, and the system receives the change in capacitance between the conductive cloth and the human body; wherein the change is represented by a frequency, cycle, voltage or current change. 154.-. (canceled)55. A system for generating physiological signals using a cloth capacitive sensor , comprisingat least a piece of cloth,at least one conductive area arranged on the cloth,a signal circuit;a capacitive sensor formed between the conductive cloth and a human body;a resistor R, a capacitor C, an inductor L, an operational amplifier, a diode, a Schmitt trigger, CMOS, a transistor, or an IC, connected, in series or in parallel, with the cloth capacitive sensor to form a charge and discharge circuit to change a signal range of frequency, cycle, voltage or current;wherein when a force, pressure, tensile force, torsion or tension is applied between the human body and the cloth, the capacitance changes, the circuit sends a signal, and the system receives the change in capacitance between the conductive cloth and the human body; wherein the change is represented by a frequency, cycle, voltage or current change, which is used to analyze at least one information of physiological and posture changes of human body, medium change between the human body and the cloth, or information of force applied.56. The system for ...

METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS

A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method is administered in combination with localized internal ionizing radiation therapy. 1. A method of simultaneously providing localized internal ionizing radiation therapy in combination with thermal therapy to a target site in a patient in need thereof , the method comprisingadministering to the patient a composition of nanoparticles, the nanoparticles containing at least one radioactive isotope and coated with anti-tumor antibodies, the radioactive nanoparticle resulting in radiation therapy at a dose sufficient to damage tumor-associated vessels at the localized target site, andadministering localized thermal therapy at the target site essentially simultaneously during the radiation therapy.3. The method of where the target is a tumor site.4. The method of where the target is neovascularization tissue.5. The method of where the target is endothelial cells in new blood vessels in a patient with exudative age related macular degeneration.6. The method of wherein the radioactive nanoparticle is a magnetic claim 1 , diamagnetic claim 1 , ferromagnetic claim 1 , non-ferromagnetic and/or paramagnetic nanoparticle.7. The method of wherein the antitumor antibody is coated on or conjugated with the radioactive nanoparticle.8. The method of wherein the composition is administered intravenously.9. The method of wherein the radioactive isotope is an α-emitting isotope claim 1 , a β-emitting isotope claim 1 , or a combination thereof.10. The method of wherein the isotope is selected from the group consisting of AtAc claim 9 , Bi claim 9 , Bi claim 9 , Ra claim 9 , Pb claim 9 , Tb claim 9 , I claim 9 , cu claim 9 , I claim 9 , Bi claim 9 , and Bi11. The method of wherein the dose of the isotope ranges from 10 μCi to 20 claim 9 ,000 μCi.12. The method of wherein thermal therapy is applied with a controlled energy ...

NON-INVASIVE MAGNETIC OR ELECTRICAL NERVE STIMULATION TO TREAT OR PREVENT DEMENTIA

Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient. 1. A method of treating or preventing dementia in a patient , comprising:positioning a device adjacent to a skin surface of the patient;generating one or more electrical impulses with said device; andtransmitting the electrical impulses to selected nerve fibers in the patient, wherein the electrical impulses are sufficient to modify dementia within the patient.2. The method of wherein the transmitting step comprises transmitting the electrical impulses from one or more electrodes through a conducting medium within the device.3. The method of wherein the electrical impulses are transmitted transcutaneously through an outer skin surface of the patient to generate an electrical impulse at or near the selected nerve fibers.4. The method of further comprising generating an electrical field at or near the device and shaping the electrical field such that the electrical field is sufficient to modulate a nerve fiber at the target region; and wherein the electric field is not sufficient to substantially modulate a nerve or muscle between the outer skin surface and the target region.5. The method of wherein the electric field at the nerve fiber at the target region is between about 10 to 600 V/m.6. The method of wherein the electric field is less than 100 V/m.7. The method of ...

NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE

Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. The attacks comprise asthma attack, epileptic seizure, attacks of migraine headache, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, onset of ventricular fibrillation or tachycardia, panic attack, and attacks of acute depression. The imminence of an attack is forecasted using grey-box or black-box models as used in control theory. In preferred embodiments of the disclosed methods, a vagus nerve in the neck of a patient is stimulated noninvasively to avert the attack. 1. A method of averting the onset of an acute medical event in a patient , comprising: using one or more sensors to detect physiological and/or environmental signals within , on , and/or about the patient; using values of said signals to forecast the onset of the acute medical event; positioning a device adjacent to a skin surface of the patient; generating one or more electrical impulses with the device; and transmitting the electrical impulses to selected nerve fibers in the patient to treat the acute medical event.2. The method of further comprising generating shaped electrical impulses within the device and transmitting them to the patient through a conducting medium within the device.3. The method of wherein the electrical impulses are sufficient to avert an acute event claim 1 , selected from a group of events comprising asthma attack claim 1 , epileptic seizure claim 1 , attack of migraine headache claim 1 , transient ischemic attack or stroke claim 1 , onset of atrial fibrillation claim 1 , myocardial infarction claim 1 , onset of ventricular fibrillation or tachycardia claim 1 , panic attack claim 1 , and attack of acute depression.4. The method of wherein the electrical impulses are transmitted transcutaneously through an outer skin surface of the patient to ...

Apparatus And Methods For Determining A Property Of A Tissue

An apparatus for determining a thermal property of tissue includes a base unit with one or more energy source and at least two, preferably detachable, leads. The distal end of each lead, which is introduced into the tissue to be treated, has at least two longitudinally spaced temperature measuring elements to measure surrounding tissue temperature and at least two longitudinally spaced electrode surfaces for applying current to the tissue. Each distal end is also provided with an element which uses energy emitted by the sources of energy to heat up the surrounding tissue. The base unit has computing elements, current generating elements for generating an alternating current, and conductance determining elements for determining the tissue conductance between pairs of electrode surfaces based on the alternating current applied by the current generating elements to the tissue. Methods for using the device and leads for use in the device are also described.

Dissection handpiece and method for reducing the appearance of cellulite

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Self operated esthetic device with a substrate

The present invention provides a self-operated device for treating a skin of a patient, comprising: a. a substrate having a first side and a second side; b. a plurality of RF electrodes arranged in said substrate, said RF electrodes are configured to emit RF radiation from said first side to the surface of said skin; c. at least one RF generator configured to generate pulses of current to said RF electrodes; and, d. a control unit connected to said at least one RF generator, said control unit is adapted to control the operation of said RF electrodes; wherein said control unit is adapted to control the operation of said RF electrodes according to a predetermined treatment protocol, such that the same activates or deactivates at least one of said RF electrodes at any predetermined time interval according to a predetermined pattern so as to achieve a particular therapeutic result.

Treating bacteria with electric fields

Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time at particular frequencies with particular filed strengths. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.

Treating cancer using electromagnetic fields in combination with photodynamic therapy

A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.

Dissection handpiece and method for reducing the appearance of cellulite

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Composite electrode

An electrode for applying electric fields to a patient includes a plurality of ceramic elements (e.g., ceramic discs) that are designed to be positioned against the patient's skin. Electrical connections are made to the ceramic elements (e.g., using a flex circuit). Temperature sensors (e.g., thermistors) are preferably provided at at least some of the ceramic elements to sense the temperature at the skin beneath the ceramic elements, so that appropriate action can be taken if an overtemperature condition is detected.

METHODS TO ARREST CANCER CELL GROWTH AND PROLIFERATION USING ELECTROMAGNETIC ENERGY DELIVERED VIA ELECTROMAGNETIC COIL SYSTEMS

A non-invasive method of using electromagnetic field energies to reduce or arrest the growth rate and proliferation of cancer cells, and induce apoptosis in cancer cells, and reduce or arrest the growth and survival of foreign pathogens, relatively without significantly harming normal cells beyond their physiologic threshold of survival are provided. The methods described herein are intended to be used toward the treatment of cancer in human or animals within the context of cancer therapeutics. 1. An apparatus , comprising:a transducer adapted to conduct current;a current generator adapted to induce a current flow in the transducer; andwherein the transducer is located proximate to a treatment site, the treatment site comprising healthy cells and one or more of a foreign pathogen and cancer cells such that when current flow is induced in the transducer an electromagnetic field is produced that induces growth arrest and/or apoptosis in one or more of the foreign pathogens and the cancer cells by generating an electromagnetic field that comprises a peak amplitude greater than 100 V/cm.2. The apparatus of claim 1 , wherein the transducer comprises a coil winding and wherein the current generator generates about a 27 MHz bipolar sinusoidal current.3. The apparatus of claim 2 , wherein the current is pulsed for a predetermined duration at a predetermined pulse rate.4. The apparatus of claim 3 , wherein the predetermined pulse duration is between about 1 and 3 microseconds in duration.5. The apparatus of claim 1 , wherein the treatment site comprises the foreign pathogen and wherein the foreign pathogen comprises one or more of bacteria claim 1 , a virus claim 1 , a fungus claim 1 , and a parasite.6. The apparatus of claim 1 , wherein the electromagnetic field is intermittently turned on and off over the course of a treatment period.7. The apparatus of claim 6 , wherein the electromagnetic field is intermittently turned on and off on a periodic basis during the treatment ...

Heating/sensing catheter apparatus for minimally invasive applications

Catheter apparatus comprises a coaxial cable having proximal and distal ends. The cable includes a hollow center conductor, an outer conductor and an electrically insulating layer between the conductors. An antenna is at the distal end of the cable, and a diplexer is connected to the cable, the diplexer including a transmit path for connecting the antenna to a transmitter which transmits first frequency signals and a receive path for connecting the antenna to a receiver which detects second frequency signals the diplexer isolating the signals on the two paths from one another. A transmission line connects the cable to the diplexer, the transmission line having a segment with a tubular inner conductor one end of which is connected to the center conductor and a second end of which is adapted for connection to a coolant source, the center and inner conductors forming a continuous coolant pathway.

Wound care method and system with one or both of vacuum-light therapy and thermally augmented oxygenation

A combination therapy pad that includes a first layer and a second layer operatively coupled to the first layer. A fiber-optic array is disposed between the first layer and the second layer. A third layer is operatively coupled to the first layer. The third layer includes a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source. The third layer provides at least one of vacuum therapy and therapeutic fluid treatment to a wound area.

Diathermy Applicator Garment

A therapeutic diathermy applicator is proposed which minimizes the common problem of burning of skin patient. The heat distribution arising as a result of unwanted capacitive effects is modeled as a manifestation of ‘conservative’ energy. A specific spatial characteristic of RF stimulation is determined and incorporated into the design of the applicator in order to achieve these goals.

Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules

An apparatus and method for electromagnetic treatment of plants, animals, and humans comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said target pathway structure using a coupling device.

APPARATUS, TIP AND METHOD FOR TREATING TISSUE

Disclosed is an apparatus for treating tissue. The apparatus includes a chamber having an opening, the chamber configured to, when placed proximate to the tissue, cause periodic movement of an area of the tissue raised towards the opening of the chamber, and one or more energy transmitting elements to apply energy to at least a portion of the area of the tissue. 1. An apparatus for treating tissue , the apparatus comprising:a vacuum chamber having an opening, the vacuum chamber configured to, when placed proximate to the tissue, cause periodic movement of an area of the tissue raised towards the opening of the vacuum chamber;a vacuum pump coupled to the vacuum chamber, the vacuum pump configured to cause a sequence of vacuum pulses to be created in the vacuum chamber; andone or more energy transmitting elements to apply energy to at least a portion of the area of the tissue within the vacuum chamber, the one or more energy transmitting elements including:two or more energy transmitting elements from the set of: (1) at least one light source arranged to deliver light into the vacuum chamber, (2) one or more radio frequency energy transmitting elements arranged on rollers across the opening of the vacuum chamber, and (3) one or more ultrasound energy transmitting elements;wherein the one or more energy transmitting elements are configured to apply a sequence of energy pulses to the at least the portion of the raised area of the tissue when a computed vacuum level for the vacuum chamber exceeds a first threshold value and to terminate application of the energy to the at least the portion of the raised area of the tissue when the computed vacuum level for the vacuum chamber is at a second pre-determined threshold value; andwherein an energy pulse is applied for every n vacuum pulses, with n equaling an integer.2. The apparatus of wherein the rollers are configured to move inward and outward across the opening of the vacuum chamber.3. The apparatus of wherein the one or ...

METHODS AND DEVICES TO TREAT NASAL AIRWAYS

A method is described for modifying at least one property of a tissue of or near a nasal valve of a nose, without using a surgical incision or an implant, to decrease airflow resistance or perceived airflow resistance in a nasal airway. The method may involve contacting a treatment element of a treatment device with the at least one tissue inside the nasal airway, with sufficient force to at least temporarily deform the at least one tissue, applying energy to, or removing energy from, the at least one tissue, using the treatment element, and removing the treatment element from the nostril. 1. A method of modifying at least one property of at least one tissue of or near a nasal valve of a nose , without using a surgical incision or an implant , to decrease airflow resistance or perceived airflow resistance in a nasal airway , the method comprising:contacting a treatment element of a treatment device with the at least one tissue inside the nasal airway, with sufficient force to at least temporarily deform the at least one tissue;applying energy to, or removing energy from, the at least one tissue, using the treatment element; andremoving the treatment element from the nostril.2. A method as in claim 1 , wherein the treatment element has a convex shape claim 1 , such that contacting the treatment element against the at least one tissue at least temporarily deforms the tissue into a concave shape.3. A method as in claim 2 , wherein contacting the treatment element with the tissue causes at least one protrusion on the treatment element to deform the tissue.4. A method as in claim 1 , wherein applying energy comprises applying energy in a form selected from the group consisting of ultrasound claim 1 , microwave claim 1 , heat claim 1 , radiofrequency claim 1 , electrical claim 1 , light and laser.5. A method as in claim 4 , wherein applying energy comprises delivering radiofrequency energy to one or more electrodes of the treatment element to locally heat the at least one ...

Chemical exchange saturation transfer system for characterization, diagnosis, and treatment of a health condition

A system and method for treating cancer by integrating a hemodynamic parameter (Hdp) monitoring system and a radiofrequency generator synchronized by a processing system is disclosed. The system is capable of identifying health condition-specific Hdp variation values changes in a patient upon the exposure of low energy amplitude modulated electromagnetic fields frequencies. A system and method for treating cancer by integrating a hemodynamic parameter (Hdp) monitoring system, a radiofrequency generator synchronized by a processing system, and a chemical exchange saturation transfer (CEST)-MRI system is further disclosed. The exposure of the modulated frequencies influences cellular functions, such as microtubule conductivity or cellular metabolism, 1460 or malfunctions in a patient and can provide both a therapeutic and predictive and prognostic effect for the patient, providing for both treatment of a specific ailment or disease such as hepatocellular carcinoma as well as predictive results of how effective the treatment is likely to be. The construction of a library of frequencies can be used to more efficiently and effectively diagnose and treat a health condition in patients by auto-tuning a treatment regimen specifically to the patient.

TOOTHBRUSH

A toothbrush comprising a body comprising a handle portion, a head portion and a longitudinal axis; a plurality of tooth cleaning elements extending from the head portion; a depression formed in an outer surface of the handle portion of the body, the depression comprising a floor; a power source disposed within the body; an electromagnetic radiation (EMR) source disposed within the handle portion and operably coupled to the power source, the EMR source configured to emit EMR from the floor of the depression; and a cover coupled to the handle portion so as to be alterable between: (1) a storage state in which the depression is enclosed by the cover; and (2) a use state in which the floor of the depression is exposed. 1. A toothbrush comprising:a body comprising a handle portion, a head portion and a longitudinal axis;a plurality of tooth cleaning elements extending from the head portion;a depression formed in an outer surface of the handle portion of the body, the depression comprising a floor;a power source disposed within the body;an electromagnetic radiation (EMR) source disposed within the handle portion and operably coupled to the power source, the EMR source configured to emit EMR from the floor of the depression; anda cover coupled to the handle portion so as to be alterable between: (1) a storage state in which the depression is enclosed by the cover; and (2) a use state in which the floor of the depression is exposed.2. The toothbrush according to wherein the depression is longitudinally elongated.3. The toothbrush according to wherein the floor of the depression is concave.4. The toothbrush according to wherein an outer surface of the handle portion is substantially flush with an outer surface of the cover when the cover is in the storage state.5. The toothbrush according to further comprising a bite guard protruding from the floor of the depression claim 1 , the EMR source configured to emit EMR from the floor of the depression adjacent the bite guard.6. ...

VAGAL NERVE STIMULATION FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS

Devices, systems and methods are disclosed for treating one or more symptoms of central nervous system disorders in a patient, such as anxiety disorders, fibromyalgia, traumatic brain injury, PTSD, and others. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced. For chronic treatment of such disorders, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms. 1. A device for treating symptoms of a central nervous system disorder in a patient , the device comprising:one or more electrodes configured for contacting an outer skin surface of the patient; andan energy source coupled to the electrodes, wherein the energy source is configured to generate at least one electrical impulse and to transmit the at least one electrical impulse transcutaneously from the electrodes through the outer skin surface of the patient to a vagus nerve in the patient according to a stimulation protocol that includes at least two doses administered each day for a plurality of days, wherein the doses each have a duration of about ninety seconds to about 3 minutes; andwherein the electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced.2. The device of claim 1 , wherein the energy source is wirelessly coupled to the one or more electrodes.3. The device of claim 1 , further comprising an electrical connector coupling the energy source to the one or more electrodes.4. The device of claim 1 , wherein the one or more electrodes are configured for attachment to the ...

METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy. 117-. (canceled)18. A method for treating a hypertensive human patient , the method comprising:intravascularly positioning a thermal apparatus carried by a renal denervation catheter at least proximate to renal nerves of the patient;delivering thermal energy via the thermal apparatus to modulate a function of the renal nerves via thermal effects; andintravascularly removing the renal denervation catheter from the patient after delivering the thermal energy to conclude the procedure.19. The method of wherein intravascularly positioning a thermal apparatus comprises intravascularly positioning the thermal apparatus within a renal artery of the patient proximate to the renal nerves.20. The method of wherein the renal denervation catheter comprises an expandable element at a distal region of the catheter claim 18 , and wherein the thermal apparatus is carried by the expandable element claim 18 , and wherein the method further comprises:transforming the expandable element from a low-profile delivery configuration to an expanded treatment configuration within a renal artery of the patient after intravascularly positioning the thermal apparatus at least proximate to renal nerves and before delivering ...

CORNEAL DENERVATION FOR TREATMENT OF OCULAR PAIN

Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment. 1. A method of treating a cornea of an eye , comprising:applying an apparatus to an anterior surface of a cornea, wherein the cornea comprises an epithelium, a stroma, an inner portion and an outer portion; andapplying energy from the apparatus to denervate a region of the cornea corresponding to a denervation treatment profile.2. The method of claim 1 , wherein treating comprises denervating a portion of the cornea.3. The method of claim 1 , wherein treating comprises denervating an inner portion of the cornea.4. The method of claim 1 , wherein the apparatus comprises an annular ring configured to contact the cornea.5. The method of claim 1 , wherein the energy comprises radiofrequency energy claim 1 , heating claim 1 , cooling claim 1 , light claim 1 , or ultrasound.6. The method of claim 1 , wherein applying energy comprises applying energy to the outer portion according to the denervation treatment profile.7. The method of claim 1 , wherein denervating comprises severing axons in the region of the cornea.8. The method of claim 1 , wherein denervation comprises stunning corneal nerves claim 1 , increasing the threshold of the corneal nerves claim 1 , inhibiting corneal nerve transmission claim 1 , ...

CHIP FOR TRANSDERMAL EMISSION OR AUGMENTATION OF ENERGY

A hologram chip may be programmed to emit and/or augment energy tuned to interact with bodily functions through transdermal contact. The chip may be programmed by using a pair of Tesla pancake coils, each coupled to a spherical electrode and driven to create an energetic field between the electrodes. Embodiments may include systems that include the programmed hologram chip in a fabric body. The systems may be wearable so that the effects of the programmed chip may be applied to selected areas of the human body. Some embodiments may be useful for augmenting healing of ailments. 1. A system for transdermal emission and/or augmentation of energy to a user , comprising:a chip body;a holographic layer of the chip body;a hologram in the holographic layer, the hologram configured to emit and/or augment energetic information tuned via longitudinal carrier waves from a pair of pancake coils passed through a tuning medium, the energetic information of the hologram being tuned for interaction with a bodily function; anda fabric body, wherein the chip body is attached to the fabric body, the chip body disposed to transmit energy transdermally from the hologram to the user.2. The system of claim 1 , wherein the chip body is positioned on an exterior surface of the fabric body for direct contact with skin of the user.3. The system of claim 2 , further comprising a medicated adhesive on the chip body claim 2 , wherein the energetic information of the hologram is tuned for interaction with the medicated adhesive.4. The system of claim 2 , further comprising a gel on the chip body claim 2 , wherein the energetic information of the hologram is tuned for interaction with the gel to create a transdermal reaction on skin of the user.5. The system of claim 2 , further comprising an ointment on the chip body claim 2 , wherein the energetic information of the hologram is tuned for interaction with the ointment to create a transdermal reaction on skin of the user.6. The system of claim 1 , ...

Electrostatic drug delivery

A method for targeted drug delivery. The method includes preparing a drug composition with a surface electric charge, injecting the drug composition into a cancer patient's body, placing an electrically conductive element in a region next to a tumor location inside the cancer patient's body, and delivering the drug composition to the tumor location. Delivering the drug composition to the tumor location includes electrostatically trapping the drug composition within the tumor location by applying an electrostatic field with an opposite sign of electric charge to a sign of the surface electric charge of the drug composition to the electrically conductive element.

CATHETER-BASED DEVICES AND ASSOCIATED METHODS FOR IMMUNE SYSTEM NEUROMODULATION

Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient. 1. A method of treating an autoimmune condition associated with inflammation , the method comprising:intravascularly positioning a neuromodulation catheter having an energy delivery element at a treatment location within a blood vessel proximate to neural fibers innervating a splenic artery or a splenic vein of the patient;delivering neuromodulation energy to the neural fibers innervating the splenic artery or the splenic vein of the patient to reduce inflammation and modulate an immune response; andrepeating neuromodulation at the treatment location until a level or activity of one or more markers of inflammation including interleukins, high-sensitivity C-reactive proteins, erythrocyte sedimentation rate (ESR) or heat shock proteins reaches a benchmark.2. The method of claim 1 , wherein the autoimmune condition includes multiple sclerosis claim 1 , lupus or psoriasis.3. The method of claim 1 , wherein delivering the neuromodulation energy reduces or prevents an increase in the level or activity of the one or more markers of inflammation.4. The method of claim 1 , further comprising:measuring the level or activity of the one or more markers of inflammation after delivery of the neuromodulation energy; andcomparing the ...

TOPICAL COOLED DERMAL DEVICE

A dermal device for skincare therapy is provided including: a fluid circuit including a fluid pump and a reservoir; and a dermal interface configured to contact a user's skin, the dermal interface including at least one electrode and part of the fluid circuit having at least one perforation, wherein the electrode(s) is configured to deliver an energy pulse to the contacted skin, wherein the reservoir is configured to hold at least one topical, wherein the fluid pump is configured to pump the least one topical through the fluid circuit and extrude the topical through the dermal interface. 1. A dermal device for skincare therapy comprising:a fluid circuit including a fluid pump and a reservoir; and 'the dermal interface including at least one electrode and part of the fluid circuit having at least one perforation,', "a dermal interface configured to contact a user's skin,"}wherein the electrode(s) is configured to deliver an energy pulse to the contacted skin,wherein the reservoir is configured to hold at least one topical,wherein the fluid pump is configured to pump the least one topical through the fluid circuit and extrude the topical through the dermal interface.2. The dermal device of claim 1 , wherein the perforation is configured to surround the electrode interfacing the skin.3. The dermal device of claim 1 , wherein an energy pulse is applied to the skin configured to reduce a skin impedance claim 1 ,wherein the contacted skin is conditioned for the skincare therapy by a reduction in the skin impedance.4. The dermal device of claim 1 , wherein the topical is chilled claim 1 ,wherein the contacted skin is conditioned for the skincare therapy by a reduction in temperature.5. The dermal device of claim 1 , wherein the dermal interface is configured to be removable.6. The dermal device of claim 1 , including a power source to generate the energy pulse.7. A method for conditioning a user's skin claim 1 , the method comprising:applying a chilled topical and an ...

Arrays for Longitudinal Delivery of TTFields to a Body

Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region. 1. An apparatus for treating a target region in a limb of a subject's body with TTFields , the apparatus comprising:a first set of one or more capacitively coupled electrodes;a first substrate configured to hold the first set of one or more electrodes against the subject's body so that the first set of one or more electrodes partially surrounds a first side of the limb at a position that is proximal to the target region;a second set of one or more capacitively coupled electrodes;a second substrate configured to hold the second set of one or more electrodes against the subject's body so that the second set of one or more electrodes partially surrounds a second side of the limb at a position that is distal to the target region, wherein the second side of the limb is opposite to the first side of the limb;a third set of one or more capacitively coupled electrodes;a third substrate configured to hold the third set of one or more electrodes against the subject's body so that the third set of one or more electrodes partially surrounds the second side of the limb at a position that is proximal to the target region;a fourth set of one or more capacitively coupled electrodes; ...

Arrays for Longitudinal Delivery of TTFields to a Body

Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region. 1. A kit of electrodes for treating a target region in a subject's body with TTFields , the target region being located in a portion of the subject's body that has a longitudinal axis , the apparatus comprising:a first plurality of capacitively coupled electrodes wired together in parallel, in series, or in a parallel/series combination;a first band-shaped substrate configured to hold the first plurality of electrodes against the subject's body so that the first plurality of electrodes surrounds a first part of the subject's body at a position that is longitudinally prior to the target region;a second plurality of capacitively coupled electrodes wired together in parallel, in series, or in a parallel/series combination;a second band-shaped substrate configured to hold the second plurality of electrodes against the subject's body so that the second plurality of electrodes surrounds a second part of the subject's body at a position that is longitudinally subsequent to the target region;a third plurality of capacitively coupled electrodes wired together in parallel, in series, or in a parallel/series combination;a third substrate configured to hold the third plurality of ...

METHODS FOR TREATING URINARY STRESS INCONTINENCE

Methods for treating urinary stress incontinence by non-invasively delivering energy to one or more submucosal regions of vaginal tissue to induce remodeling within the vaginal tissue are provided. In some embodiments, the energy delivery results in heating of the target tissue to a temperature that ranges from about 38° C. to about 46° C. In some embodiments, the subject methods involve cooling a mucosal epithelial layer over the vaginal tissue. In some embodiments, a reverse thermal gradient is produced as the mucosal epithelium is cooled while energy is delivered to the underlying vaginal tissue. 1. A method for treating urinary stress incontinence in a subject , the method comprising:non-invasively delivering energy to one or more submucosal regions of a vaginal tissue, thereby heating the one or more submucosal regions to a predetermined temperature; andremodeling the one or more submucosal regions of the vaginal tissue of the subject to treat the subject for urinary stress incontinence,wherein the one or more submucosal regions are located within 4 predetermined quadrants around a vaginal canal,wherein the one or more submucosal regions comprise 20 target tissue locations, such that each of the 4 predetermined quadrants comprises 5 target tissue locations,wherein non-invasively delivering energy comprises executing at least 10 energy delivery passes in each of the 4 predetermined quadrants,wherein each of the at least 10 energy delivery passes comprises applying, in a predetermined order, 1 to 5 energy pulses to each of the 5 target tissue locations in each of the 4 predetermined quadrants, andwherein non-invasively delivering energy comprises delivering at least 20 energy pulses to two or more submucosal regions of a vaginal tissue that is located alongside a urethra of the subject.2. The method of claim 1 , wherein executing at least 10 energy delivery passes in each of the 4 predetermined quadrants comprises:executing a first series of 5 energy delivery ...

Systems and Methods for Thermal Stimulation of the Spinal Cord

Methods and systems for providing dosed and calibrated thermal stimulation using an implantable stimulation device are disclosed. Aspects of the disclosure provide bioheat models based on physiological and thermal properties of target anatomy and thermopole algorithms that interact with the bioheat models to derive thermal stimulation parameters for providing dosed and calibrated thermal stimulation. Also, graphical user interfaces (GUIs) are disclosed for configuring and targeting heat delivery into specific targets. 1. A neuromodulation system comprising:an external device comprising a graphical user interface (GUI) for programming an implantable stimulator device, wherein the implantable stimulator device comprises a plurality of thermodes configured to contact a patient's tissue,wherein the external device comprises a control circuitry programmed to execute at least a thermopole algorithm, ["receive, via the GUI of the external device, one or more inputs indicating one or more prescribed thermopoles in the patient's tissue, and", 'based on the received one or more inputs, provide the thermal stimulation parameters to the implantable stimulator device for generating the one or more prescribed thermopoles., 'wherein the thermopole algorithm is configured to2. The neuromodulation system of claim 1 , wherein the control circuitry is further programmed to execute at least a bioheat model claim 1 , wherein the bioheat model is configured to model a thermal response of the patient's tissue to thermal stimulation provided to the patient's tissue by the one or more of the plurality of thermodes and select one or more thermal stimulation parameters for providing the one or more prescribed thermopoles.3. The neuromodulation system of claim 1 , wherein the GUI comprises a representation of the one or more thermodes in relation to the patient's tissue and is configured to represent the one or more prescribed thermopoles.4. The neuromodulation system of claim 2 , wherein the ...

Pulsed electromagnetic field treatment

A method of treating a subject includes providing a mobile telecommunications device including a processor, a transceiver coupled to the processor including a transmitter for generating pulsed electrical signals adapted to be coupled to an antenna, at least one memory device accessible by the processor. The mobile telecommunications device is positioned proximate to the subject. Pulsed electrical signals are begun to be generated to cause the transmitter to drive the antenna, wherein the antenna in response to the pulsed electrical signals emits a pulsed electromagnetic field (PEMF) that reaches the subject to provide treatment.

RADIOFREQUENCY TREATMENT PROBE FOR TREATING VAGINAL LAXITY AND ASSOCIATED SYSTEMS AND METHODS

The present invention is related to a radiofrequency treatment probe and method delivering radiofrequency for controlled heating of tissue within the vagina for the treatment of vaginal laxity. The treatment probe may include a curved, rounded disposable treatment tip that may be designed to accommodate vaginal anatomy. An electrode assembly may be coupled to the treatment tip, wherein the electrode coupled to the treatment tip may be configured to transfer radiofrequency energy through vaginal skin surface to the tissue. A temperature measuring feature may include or be coupled to the electrode assembly, wherein the electrode assembly may be configured to regulate and maintain a pre-determined skin temperature. A radiofrequency handle may be configured to connect to a disposable treatment tip. A connector may be configured to connect to the radiofrequency handle to a radiofrequency generator. A protective apparatus may be configured to protect the radiofrequency handle. 1. A treatment probe comprising:a. a curved, rounded treatment tip designed to accommodate vaginal anatomy;b. an electrode assembly coupled to the treatment tip, wherein the electrode coupled to the treatment tip is configured to transfer radiofrequency energy to specific vaginal structures;c. a temperature measuring feature coupled to the electrode assembly, wherein the temperature measuring feature coupled to the electrode assembly is configured to monitor and regulate electrode and skin temperature;d. a connector configured to connect the treatment tip to a radiofrequency generator.2. The treatment probe according to further comprising a protective apparatus configured to protect the treatment tip.3. The treatment probe according to wherein the treatment tip is connected to the radiofrequency generator by a radiofrequency handle claim 1 , and wherein the radiofrequency handle is configured to be reusable.4. The treatment probe according to wherein the electrode assembly comprises:a. a conductive ...

Apparatus and cosmetic method for providing cooling to a skin tissue treatment head

A device for cooling the skin tissue of a patient during a procedure using energy includes a mat-like structure, the mat-like structure having a bottom wall, a top wall and upstanding walls connecting the top wall and the bottom wall, the walls defining an enclosed volume; it also includes one or more electrodes positioned to protrude from the bottom wall and extend through the volume for connection to a source of energy; further, the volume defines a space for holding a cooling substance for cooling the one or more electrodes and the skin tissue during an energy-based procedure.

INDUCTION HEATING APPLICATIONS

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat. 1. An apparatus comprising:a plurality of inductive heating elements;a non-ferrous divider positioned between the plurality of inductive heating elements; anda radiation source configured to deliver electromagnetic radiation to heat at least a portion of the plurality of inductive heating elements to form a pattern to be illuminated on the apparatus.2. The apparatus of claim 1 , wherein the plurality of inductive heating elements are arranged in a grid on the apparatus.3. The apparatus of claim 1 , wherein the at least a portion of the plurality of inductive heating elements are configured to be lit up from the heat to illuminate the pattern.4. The apparatus of claim 1 , wherein the at least a portion of the plurality of inductive heating elements are configured to heat another material positioned proximate to the at least a portion of the plurality of inductive heating elements to illuminate the pattern.5. The apparatus of claim 1 , wherein the plurality of inductive heating elements are arranged in a first pattern and the at least a portion of the plurality of inductive heating elements that are heated form a second pattern.6. The apparatus of claim 1 , wherein the non-ferrous divider is an insulating divider.7. The apparatus of claim 1 , wherein each of the plurality of inductive heating elements is separated from another one of the plurality of inductive heating elements by the non-ferrous divider.8. The apparatus of claim 1 , further comprising a computing device configured to determine the pattern. ...

Methods for thermally-induced renal neuromodulation

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

RENAL NEUROMODULATION FOR TREATMENT OF PATIENTS

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based. 150-. (canceled)51. A method of treating a disease of a human patient diagnosed with at least one of heart failure , hypertension , acute myocardial infarction , impaired renal function , or chronic renal failure , the method comprising:positioning an energy transfer device within a renal blood vessel and in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; andthermally modulating the neural fibers with the device, wherein thermally modulating the neural fibers results in a therapeutically beneficial reduction in blood pressure of the patient.52. The method of wherein thermally modulating the neural fibers with the device comprises thermally modulating one or more afferent neural fibers.53. The method of wherein thermally modulating the neural fibers with the device comprises thermally modulating one or more efferent neural fibers.54. The method of wherein thermally modulating the neural fibers with the device comprises at least partially ablating at least one of an efferent neural fiber and an afferent neural fiber with the device.55. The method of wherein thermally modulating the neural fibers comprises reducing neural activity along the neural fibers with the device within the renal blood vessel.56. The method of wherein reducing neural activity along the neural fibers with the device from within the renal blood vessel comprises reducing afferent neural activity along the neural fibers.57. The method of wherein reducing neural activity across the neural fibers with the device from within the renal blood vessel comprises reducing efferent neural activity across the neural fibers. ...

RENAL NEUROMODULATION FOR TREATMENT OF PATIENTS

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based. 143-. (canceled)44. A method of treating a human patient diagnosed with at least one of heart failure , hypertension , acute myocardial infarction , renal disease , or chronic renal failure , the method comprising:positioning an electrode within a renal blood vessel and proximate to post-ganglionic neural fibers that innervate a kidney of the patient; andgenerating an electric field via the electrode such that at least a portion of the neural fibers are in the electric field,wherein the electric field reduces neural communication along the neural fibers and significantly improves a measurable physiological parameter corresponding to the disease of the patient.45. The method of wherein positioning an electrode within a renal blood vessel and proximate to post-ganglionic neural fibers comprises placing the electrode in a renal artery of the patient.46. The method of wherein generating an electric field comprises generating a monopolar electric field.47. The method of wherein generating an electric field via the electrode comprises generating a bipolar electric field.48. The method of wherein the electrode is a first electrode claim 44 , and wherein the method further comprises positioning a second electrode within the renal blood vessel and proximate to the post-ganglionic neural fibers claim 44 , and wherein generating an electric field comprises generating a bipolar electric field between the first and second electrodes.49. The method of wherein generating an electric field via the electrode such that at least a portion of the neural fibers are in the electric field comprises at least partially ablating the neural ...

Method for the production of sub-micrometric particles and their theranostic use in oncology with a specific apparatus

The invention relates to a method for producing sub-micrometric particles, which comprises: mechanochemical treatment of homogeneous or heterogeneous magnetic materials until a mass which consists mostly of magnetic nanocrystal aggregates is obtained; selection of aggregates so that the nanocrystals have a Curie temperature within a predefined variation range; functionalization of the aggregates in order to obtain coating thereof with molecules of one or more of the following types of substances: substances for which the tumour cells have a particular metabolic avidity; substances having a biochemical affinity with the tumour cells; substances having an affinity with the acid microenvironment which surrounds the neoplastic cells. In addition to the method the following are claimed: the particles thus produced; their theranostic use which allows the in vivo execution, without interruption, of the diagnosis or monitoring step and the therapy step by means of magnetic hyperthermia of malignant neoplasms, including those localized in the so-called “sanctuary sites” such as the central nervous system and the testicle; an apparatus designed for this use.

METHOD FOR APPLYING PULSED RADIO FREQUENCY ENERGY TO THE SPINAL CANAL

A flexible catheter includes two electrical contacts in a distal region of the catheter and a distal aperture of a hose line. The electrical contacts are connected to a high frequency pulse generator for applying pulsed radio frequency energy for nerve stimulation. A temperature sensor is located in the distal region of the catheter. The flexible catheter is inserted into a region in the spinal canal and the pulsed radio frequency generator is operated, thereby applying pulsed radio frequency energy to a localized region to be treated. The temperature at the distal region of the catheter can also be monitored, and the pulsed radio frequency energy is applied in dependence on the monitored temperature. With the catheter, pain and other medical conditions being related to and influenced by a nervous system are treated. 1. A method for applying pulsed radio frequency energy to a region in the spinal canal , comprising the steps of:inserting a flexible epidural catheter into a spinal space, said catheter having at least one first electrical contact in a distal region of the catheter;operating a pulsed radio frequency generator, the pulsed radio frequency generator being coupled to said first electrical contact; thereby applying pulsed radio frequency energy via said first electrical contact to a localized region to be treated;detecting a temperature in the spinal space by a temperature sensor at the distal region of the catheter;automatically changing at least one parameter of the pulsed radio frequency energy supplied to the localized region when a specific temperature is detected,automatically switching off or temporarily suppressing of the pulsed radio frequency energy to the localized region when an upper temperature limit is reached to thereby avoid thermal damage to tissue, andwhereby in said localized region at least one of a nerve, nerve root, a nerve ganglion and a part of the spinal cord is treated.2. A method as claimed in claim 1 , wherein the pulsed radio ...

METHOD AND APPARATUS FOR THERAPEUTIC HYPERTHERMIA DURING AN MRI SCAN

A therapeutic hyperthermia device and method for using the same includes a cooling blanket dimensioned to at least partially cover a human, a conduit coupled to the cooling blanket, and cooling liquid. Each of the cooling blanket, conduit, and cooling liquid have a negligible effect on a magnetic resonance (MR) image taken by an MRI device. The cooling liquid may have a spin-lattice relaxation time (T) and a spin-spin relaxation time (T), where either or both of T and T are less than 2 milliseconds in duration. The cooling liquid may be one of water with manganite chloride, and water with sodium chloride. 1. An apparatus for therapeutic hyperthermia of a human during a magnetic resonance (MR) imaging (MRI) by an MRI device , the apparatus comprising:a cooling blanket dimensioned to make contact with at least a portion of the human;a conduit coupled to the cooling blanket; and 'each of the cooling blanket, conduit, and cooling liquid have a negligible effect on an MR image.', 'a cooling liquid within the conduit, wherein2. The apparatus of claim 1 , wherein the cooling blanket comprises one of:two external surfaces and the conduit is coupled to at least one external surface; andtwo internal surfaces and the conduit is coupled to at least one internal surface.3. The apparatus of claim 1 , wherein the conduit is integrally formed within the cooling blanket.41212. The apparatus of claim 1 , wherein the cooling liquid has a spin-lattice relaxation time (T) and a spin-spin relaxation time (T) claim 1 , and where at least one of T and T are less than 2 milliseconds in duration.5. The apparatus of claim 1 , wherein the cooling liquid is one of: water with manganite chloride claim 1 , and water with sodium chloride.6. The apparatus of claim 1 , further comprising a temperature sensor coupled to the cooling blanket claim 1 , the temperature sensor being operative to measure a temperature of at least one of: the human claim 1 , the cooling blanket claim 1 , and the cooling ...

SYSTEMS, DEVICES AND METHODS THAT AFFECT NEURAL TISSUE THROUGH THE DELIVERY OF A PULSED RADIO FREQUENCY SIGNAL GENERATED BY AN IMPLANTABLE MEDICAL DEVICE

Radio frequency (RF) energy is transmitted through the application of a RF signal to an external RF energy interface, where the RF signal oscillates at a frequency in an energy transmission band. The transmitted RF energy is received at an implanted medical device, and energy derived from the received RF energy is stored in a direct current (DC) energy storage component of the device. A therapeutic output signal is generated from the stored energy and delivered by the implantable medical device to a patient through one or more electrodes. The therapeutic output signal is configurable to provide either one of RF stimulation therapy and RF ablation therapy, and comprises pulses of an RF signal oscillating at a frequency in a therapy band that is greater than the energy transmission band. 1. A pain management system for use in conjunction with an orthopedic implant device having a hardware component , the system comprising:an external device configured to transmit radio frequency (RF) energy through the application of a RF signal to an external RF energy interface, wherein the RF signal oscillates at a frequency in an energy transmission band; and one or more electrodes configured to be implanted in, on, or adjacent a target area of nerves,', 'an implantable RF energy interface configured to receive energy from the external RF energy interface over a wireless energy link,', 'an energy storage component configured to store the energy, and', 'a RF therapy controller coupled to the energy storage component and the one or more electrodes, the RF therapy controller configured to: 1) generate a therapeutic output signal from the stored energy, the therapeutic output signal configurable to provide either one of RF stimulation therapy and RF ablation therapy, and comprising pulses of an RF signal oscillating at a frequency in a therapy band that is greater than the energy transmission band, and 2) deliver the therapeutic output signal to one or more of the plurality of ...

Reducing Motility of Cancer Cells Using Tumor Treating Fields (TTFields)

The spreading of cancer cells in a target region can be inhibited by imposing a first AC electric field in the target region for a first interval of time, with a frequency and amplitude selected to disrupt mitosis of the cancer cells; and imposing a second AC electric field in the target region for a second interval of time, with a frequency and the amplitude selected to reduce motility of the cancer cells. The amplitude of the second AC electric field is lower than the amplitude of the first AC electric field. 1. A method of inhibiting spreading of cancer cells in a target region , the method comprising:(a) imposing a first AC electric field in the target region, the first AC electric field having a first frequency and a first amplitude, wherein the first frequency and the first amplitude are selected so that the first AC electric field disrupts mitosis of the cancer cells;(b) imposing a second AC electric field in the target region, the second AC electric field having a second frequency and a second amplitude, wherein the second frequency and the second amplitude are selected so that the second AC electric field reduces motility of the cancer cells, wherein the second frequency and the first frequency are different, and wherein the second amplitude is lower than the first amplitude.2. The method of claim 1 , wherein the second amplitude is less than 75% of the first amplitude. This application is a continuation of U.S. patent application Ser. No. 15/478,066, filed Apr. 3, 2017, which claims the benefit of U.S. Provisional Application 62/317,985, filed Apr. 4, 2016, each of which is incorporated herein by reference in their entirety.TTFields are an effective and FDA approved approach for treating tumors. Treatment using TTFields involves the continuous, noninvasive application of low intensity, intermediate frequency, alternating electric fields to a target region that includes the tumor. Previous investigations have shown that TTFields disrupt of microtubules and ...

DIELECTRIC HEADER STRUCTURE FOR REDUCING ELECTROMAGNETIC INTERFERENCE

An implantable medical device has a housing and a header attached to the housing. At least one electrode is electrically conductively connected or connectable to the header. The at least one electrode has at least one electrode contact for contacting tissue of a patient and for applying electrical stimulation pulses to the tissue and/or for detecting electrical pulses from the tissue. The header includes a dielectric material that is configured to capacitively couple RF energy acting on the device to a conductor of the implantable medical device or to the tissue of the patient when the tissue touches the header of the device. 1. An implantable medical device , comprising:a header portion attached to a housing of the device;at least one electrode electrically conductively connected or connectable to said header portion, said at least one electrode being arranged at or extending through said header portion;said at least one electrode including at least one electrode contact for contacting tissue of a patient and for applying electrical stimulation pulses to the tissue and/or for detecting electrical pulses in the tissue;said header portion being formed of a dielectric material that is configured to capacitively couple RF energy acting on the device and/or on the at least one electrode to a conductor of the implantable medical device or to the tissue of the patient when the tissue touches said header portion.2. The implantable medical device according to claim 1 , wherein the housing of the device forms said conductor of the implantable medical device.3. The implantable medical device according to claim 1 , wherein said at least one electrode is an electrode lead.4. The implantable medical device according to claim 1 , wherein said dielectric material comprises a material selected from the group consisting of crystalline barium titanate claim 1 , titanium dioxide claim 1 , barium sulfate claim 1 , barium subcarbonate claim 1 , and bismuth oxychloride.5. The implantable ...

METHOD OF TREATING OR ALLEVIATING ERECTILE DYSFUNCTION

The present invention provides a method of treating or alleviating erectile dysfunction in a patient. Multiple electrodes are placed within a segment of the internal iliac artery of the patient and against blood vessel wall of the internal iliac artery. Radiofrequency energy is released through at least one of the multiple electrodes to nearby tissues, so as to increase the temperature of the nearby tissues and induce a thermal alteration of the nearby tissues. 1. A method of treating or alleviating erectile dysfunction in a patient comprising (1) placing multiple electrodes within a segment of an internal iliac artery of the patient and against blood vessel wall of the internal iliac artery by percutaneous transluminal intravascular access; (2) adhering a surface electrode on an external surface such as skin of the patient; and (3) releasing radiofrequency energy through at least one of the multiple electrodes to nearby tissues , so as to increase the temperature of the nearby tissues and induce a thermal alteration of the nearby tissues.2. The method according to claim 1 , further comprising: adjusting or changing the adhesion position of the surface electrode on the back or butt of the patient to vary the impedance between the surface electrode and a given electrode within the internal iliac artery until the impedance falls within the range of 200-320 Ohms claim 1 , before step (2).3. The method according to claim 1 , wherein the radiofrequency energy is released at a level of no more than 9 W (joule per second) to prevent spasm of the patient.4. The method according to claim 1 , wherein the radiofrequency energy is released with a temperature threshold setting of 60° C. to ensure that collagen does not denature claim 1 , tissue does not shrink claim 1 , and cell wall does not break claim 1 , in the nearby tissue.5. The method according to claim 1 , wherein the radiofrequency energy is released through an alternating current of 460-470 KHz between the surface ...

Devices for dual mechanism aesthetic treatment and methods of use thereof

The systems and methods in accordance with the principles of the invention can promote correction of an aesthetic or functional defect in a target tissue. A method can include non-invasively applying a cooling agent to a surface of a target tissue; and cooling one or more tissue layers of said target tissue to a predetermined therapeutic temperature, wherein applying the cooling agent is performed such that cryoablation of said one or more layers of the target tissue does not occur. The system can include: a controller and a probe having a distal end configured for non-invasive contact with a surface of a target tissue to cool the target tissue based on treatment parameters.

APPARATUS AND METHOD OF NON-INVASIVE DIRECTIONAL TISSUE TREATMENT USING RADIOFREQUENCY ENERGY

Some embodiments of the invention may be related to an apparatus for non-invasive directional tissue treatment. The apparatus includes a radiofrequency (RF) generator and an array of RF energy delivery elements in active communication with the RF generator, a power source and a controller. In some embodiments, each of the RF energy delivery elements comprises a pair of electrodes with opposite polarity such that each electrode has a first dimension and a second dimension, the first dimension perpendicular to the second dimension and to an imaginary line connecting the pair of electrodes to each other. In some embodiments, the first dimension of each electrode and the distance between the electrodes in each pair are configured to create an elongated heated volume of tissue when the RF generator is activated and at least one of the RF delivery elements is in contact with the tissue. 1. An apparatus for non-invasive directional tissue treatment comprising:a radiofrequency (RF) generator;an array of RF energy delivery elements in active communication with the RF generator;a power source; anda controller,wherein each of the RF energy delivery elements comprises a pair of electrodes with opposite polarity,wherein each electrode has a first dimension and a second dimension, the first dimension perpendicular to the second dimension and to an imaginary line connecting the pair of electrodes to each other; andwherein the first dimension of each electrode and the distance between the electrodes in each pair are configured to create an elongated heated volume of tissue when the RF generator is activated and at least one of the RF delivery elements is in contact with the tissue.2. The apparatus according to claim 1 , wherein the controller is configured to cause the delivery of RF energy by the RF energy delivery elements at predetermined RF parameters to create the elongated heated volumes.3. The apparatus according to claim 1 , wherein the ratio between the first dimension and ...

ELECTRICITY ENERGY HARVESTING WITH LIQUID CRYSTAL-MAGNETIC PARTICLE COMPOSITE PARTICLES

A method and apparatus generate electrical currents and/or voltage in tissue using particles composed of liquid crystals and magnetic particles. 1. An apparatus comprising:at least one device being no more than 100 microns in any single dimension, containing at least one magnetic particle in a liquid crystal solution, and being positioned in living tissue; andan instrument for converting a magnetic field into an electrical field for application to the at least one device located in living tissue.2. The apparatus of claim 1 , wherein the at least one device is untethered within the living tissue.3. The apparatus of claim 1 , wherein one or more sections of the at least one device are coated with a biocompatible material.4. The apparatus of claim 1 , wherein one or more sections of the device are coated with a material to enhance transport to or through living tissue.5. The apparatus of claim 1 , wherein one or more sections of the device are coated with a material to enhance transport into the brain.6. A method for changing an electrical state of at least one device present in living tissue claim 1 , the method comprising:positioning the at least one device within the living tissue, wherein the at least one device is no more than 100 microns in any single dimension and contains at least one magnetic particle in a liquid crystal solution; andapplying one or more magnetic fields to the at least one device to produce electrical energy.7. The method of claim 6 , wherein the at least one device is untethered within the living tissue.8. The method of claim 6 , wherein one or more sections of the at least one device are coated with a biocompatible material.9. The method of claim 6 , wherein one or more sections of the device are coated with a material to enhance transport to or through living tissue.10. The method of claim 6 , wherein one or more sections of the device are coated with a material to enhance transport into the brain.11. A method for altering and monitoring an ...

METHODS AND SYSTEMS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy. 1117-. (canceled)118. A field generator adapted to be external to a human patient and operably coupled to an intravascular catheter having a distal electrode for treatment of the patient , the field generator comprising:non-transitory memory storing a set of instructions; anda processor coupled to the non-transitory memory, increase energy delivery, from the field generator to the electrode when the electrode is positioned at a target intravascular site, at a generally constant rate to a predetermined first power level over a predetermined first period of time;', 'maintain energy delivery to the electrode at the first power level for a second period of time; and', 'increase energy delivery to the electrode in predetermined increments following the second period of time if a measured temperature value at the target intravascular site is less than a preset temperature threshold and a measured impedance value is less than a predetermined impedance threshold, the increase in energy delivery following the second period of time continuing until the power level has reached a target maximum power threshold., 'wherein the set of instructions are configured to cause the processor to—'}119. The field ...

SYSTEM WITH AN ELECTROMAGENTIC FIELD GENERATOR WITH COILS FOR TREATING TUMORS AND A METHOD FOR TREATING TISSUE

Treatment apparatus includes a plurality of coils configured to generate time-varying magnetic fields that induce electric fields within a subject. In one example, electric field strengths of at least 1 V/cm are produced in brain tissues exhibiting Glioblastoma Multiforme (GBM). Fields are applied based on computer-assisted modeling using electromagnetic characteristics of the brain, and tissue locations identified as exhibiting disease using imaging data. A head mounted assembly of coils can be used for convenient, portable treatment. 1. A system , comprising:a plurality of coils; andan electromagnetic field generator that energizes the plurality of coils so as to apply a tumor treating field (TTF) to a specimen region, wherein the TTF has a time varying magnetic field component that induces an electric field of magnitude of at least 0.1 V/cm at a frequency of between 50 kHz and 500 kHz.2. The system of claim 1 , wherein the specimen region is associated with a tumor.3. The system of claim 2 , wherein the tissue region is associated with a brain tumor.4. The system of claim 1 , wherein the electromagnetic field generator energizes the plurality of coils so as to apply the TTF to the specimen region along a plurality of axes.5. The system of claim 1 , wherein the electromagnetic field generator sequentially energizes the plurality of coils so as to sequentially apply the TTF to the specimen region along at least two axes.6. The system of claim 5 , wherein the electromagnetic field generator energizes the plurality of coils so that the TTF is applied at a plurality of frequencies between 50 kHz and 500 kHz.7. The system of claim 1 , further comprising a rigid shell that is shaped to at least partially enclose the specimen region claim 1 , wherein the plurality of coils is secured to the rigid shell.8. The system of claim 1 , wherein the rigid shell is a portion of a helmet.9. The system of claim 1 , wherein the coils of the plurality of coils are flexibly ...

SYSTEMS AND METHODS FOR ADAPTIVE SKIN TREATMENT

According to an aspect of some embodiments of the present invention there is provided a method of dynamically adapting a facial treatment based on a current facial skin profile, comprising: using at least one sensor for measuring at least one current value of at least one variable skin characteristic of facial skin of a patient; acquiring at least one personal skin characteristic of facial skin of the patient; calculating a current facial skin status of the patient according to the at least one personal skin characteristic and the at least one current value; determining instructions to operate a treatment applicator according to the current facial skin status; and instructing the treatment applicator according to the instructions. 1. A computer implemented method of dynamically adapting a facial treatment based on a current facial skin profile , comprising:using at least one sensor for measuring at least one current value of at least one variable skin characteristic of facial skin of a patient;acquiring at least one personal skin characteristic of facial skin of the patient;calculating a current facial skin status of the patient according to the at least one personal skin characteristic and the at least one current value;calculating code instructions for operating a treatment applicator according to the current facial skin status; andactivating the treatment applicator according to the code instructions.2. The method of claim 1 , wherein calculating the current facial skin status of the patient is performed based on code executing a machine learning algorithm trained using a training set storing at least one facial skin characteristic for each of a plurality of different patients.3. The method of claim 2 , wherein the training set stores at least one calculated current facial skin status of each of the plurality of different patients claim 2 , calculated based on at least one measured current value for at least one variable skin characteristic and at least one ...

Internal Tissue Heating Apparatus

A machine holds a plurality of RF beam generators which all point at a particular location. A patient with a target volume of tissue to be treated by heat is held immobile such that the target is located at the point all the RF beams traverse. The RF beams traverse that point and the resultant generated heat treats the target. No two or more RF beams traverse any other location in the patient's body. Since each individual RF beam is too weak to cause damage, the non-targeted tissues of the patient are unharmed. 1. A machine comprising multiple RF beam generators where all said RF beam generators are spatially oriented for their beams all to pass through a region of space , called the focus , which is completely contained within some sphere of some diameter greater than or equal to 0.001 mm , and less than or equal to 10 cm.2. A method of the machine of where:a) a patient with a piece of tissue to be treated by heat, called a target, is positioned such that the focus of said RF beam generators in said machine all pass through said target;b) the machine energizes said RF beam generators, which produce RF beams which converge at said target;for the purpose of providing heat treatment to said target without affecting other tissue in said patient.3. The method of where nanoparticles are introduced into the patient's body and some of these nanoparticles are activated by the machine producing heat; thereby treating the target more effectively than heat alone would.4. The method of where a plurality of chemotherapy drugs is introduced into the patient's body and some of these nanoparticles are activated by the machine producing heat; thereby treating the target more effectively than heat alone would.5. The machine of where said machine comprises a plurality of programmable automata claim 1 , where said programmable automata control said machine.6. The machine of where each said RF beam generator is attached to the framework of said machine in a manner that its angular ...

Mobile Molecular Imaging System and Intervention System Including Same

The present invention refers to a Mobile Molecular Imaging System, for example a PET (positron emission tomography) or SPECT (single photon emission computerized tomography) device, comprising: 1. A Mobile Molecular Imaging System comprising:at least one group of n detector modules conforming detector module sets with a rounded shape comprising m detector modules each, being m Подробнее

SYSTEMS AND METHODS FOR TARGETED DEEP HYPERTHERMIA BY TIME-SHARED RF INDUCTIVE APPLICATORS

The present disclosure provides, inter alia, a system and methods for targeted hyperthermia effective to differentially heat target organs. In certain embodiments, the system and/or method utilizes one or more pairs of inductive applicators coupled to the one or more RF generators and configured to deposit radio frequency radiation on a region of interest based on a set of configurable parameters. 1. A system for targeted hyperthermia , the system comprising:one or more radio frequency (RF) generators; one or more pairs of inductive applicators coupled to the one or more RF generators and configured to deposit radio frequency radiation on a region of interest based on a set of configurable parameters; a temperature measuring device coupled to the one or more pairs of inductive applicators; and a hardware processor configured to receive temperature measurements from the temperature measuring device and cause a change on the set of configurable parameters of the one or more pairs of inductive applicators based on the received temperature measurements.2. The system of claim 1 , wherein the one or more pairs of inductive applicators utilize a hybrid drive by employing a local direct E-field and an E-field coupled to an H-field.3. The system of claim 1 , wherein the one or more pairs of inductive applicators operate in Helmholtz mode and are oriented in opposite sides causing H-field coupling and deep-seated E-field penetration.4. The system of claim 1 , wherein the one or more pairs of inductive applicators further comprise one or more semi-planar inductive loops that are configured to be temporally switched to provide targeted heating.5. The system of claim 1 , wherein the one or more pairs of inductive applicators further comprise one or more semi-planar inductive loops that are configured to be temporally switched to minimize superficial heating outside the region of interest.6. The system of claim 1 , wherein the one or more pairs of inductive applicators further ...

Apparatus and Method for Creating Small Focus Deep Hyperthermia In Tissue

A radio frequency annular phased array hyperthermia system providing a relatively small heated focal zone in a relatively large tissue mass includes a plurality of radio frequency energy applicators in at least one ring adapted to surround the relatively large tissue mass. A bolus having a dielectric constant is positioned between the energy applicators and the tissue mass. The energy applicators operate at a frequency high enough to create the relatively small heated focal zone. The spacing between adjacent applicators in the at least one ring is less than a critical distance and spacing between adjacent rings when the at least one ring is a plurality of side by side rings is less than a critical distance with such critical distances being interdependent on the frequency of the energy radiated, the dielectric constant of the bolus, the size of the bolus, and the size of the relatively large tissue mass.

METHOD AND APPARATUS FOR PREFERENTIALLY HEATING A SUBSTRUCTURE IN A COMPOSITE MATERIAL

A system () for transferring radio frequency energy to a composite structure () is provided that includes a radio signal generator () that produces a pulse modulated waveform with variable carrier frequency and variable pulse repetition frequency. The pulse modulated waveform is applied to the composite structure () for heating. An infrared imaging element () measures the rate of heating in the composite structure () for particular values of the variable carrier frequency and the variable pulse repetition frequency. The infrared imaging element () produces a representation illustrating the effects of heating on the composite structure () as well as the composite's molecular, nanoscopic structural, or chemical characteristics. A controller () determines the optimum variable center frequency and the variable pulse repetition frequency for optimum heating of the composite structure () while minimizing damage. 1. A system for transferring radio frequency energy to a composite structure comprising:a radio signal generator that produces a pulse modulated waveform with variable carrier frequency and variable pulse repetition frequency, the pulse modulated waveform is applied to the composite structure for heating;an infrared imaging element that measures the rate of heating in the composite structure for particular values of the variable carrier frequency and the variable pulse repetition frequency, the infrared imaging element produces a representation illustrating the effects of heating on the composite structure as well as the sample's molecular, nanoscopic structural, or chemical characteristics; anda controller that determines the optimum variable center frequency and the variable pulse repetition frequency for optimum heating of the composite structure while minimizing damage.2. The system of claim 1 , wherein the infrared imaging element comprises a thermal camera.3. The system of claim 2 , wherein the thermal camera illustrates regions of heating using color.4. The ...

SYSTEM FOR DEPLOYING A RESISTIVE SHAPE MEMORY CATHETERIZATION DEVICE AND METHODS FOR USE THEREWITH

A system for deploying a shape memory catheterization device within a patient, includes a catheter for endovascular insertion of the shape memory catheterization device. A heat source heats the shape memory catheterization device above the transition temperature. A transformation data generator includes a circuit driver for driving a circuit that includes at least one resistive element of the shape memory catheterization device and a detection circuit for generating transformation data based on a resistance of the at least one resistive element, wherein the transformation data indicates a shape transformation of the shape memory catheterization device from a catheterization shape to a transformed shape. 1. A system comprising:a shape memory catheterization device having a transition temperature that is higher than a normal body temperature of a patient;a catheter having a delivery rod configured to endovascularly insert the shape memory catheterization device in the patient;a heat source configured to heat the shape memory catheterization device above the transition temperature, wherein heating the shape memory catheterization device above the transition temperature causes the shape memory catheterization device to undergo a shape transformation from a catheterization shape to a transformed shape, and further causes a change in a resistance of the shape memory catheterization device as a result of the shape transformation; anda transformation data generator, coupled to the catheter, that includes a circuit driver configured to drive a detection circuit that monitors the change in the resistance of the shape memory catheterization device and to generate transformation data based on the change in the resistance of the shape memory catheterization device resulting from the shape transformation of the shape memory catheterization device.2. The system of further comprising:a heating control generator, coupled to the transformation data generator and the heat source, the ...

ESTHETIC APPARATUS USEFUL FOR INCREASING SKIN REJUVENATION AND METHODS THEREOF

The present invention provides a device for rejuvenating a region of skin or mucosal tissue, comprising: a pulsed electromagnetic frequency generator; a plurality of electrodes in communication with the pulsed electromagnetic frequency generator and an RF tissue diathermy device. The electrodes apply the pulsed electromagnetic power and the RF tissue diathermy to the tissue, heating it such that one portion of the region of mucosal tissue is maintained at a predetermined temperature range Twhile another portion of the region of mucosal tissue is at least temporarily maintained at predetermined temperature range T. 1. A device for rejuvenating at least one region of mucosal tissue , comprising:a pulsed electromagnetic frequency generator to apply pulsed electromagnetic field therapy to said region of mucosal tissue; anda plurality of electrodes in communication with an RF tissue diathermy devicewherein said RF tissue diathermy device, via said electrodes, heats said at least one region of mucosal tissue.2. The device of claim 1 , wherein at least one of the following is being held true:{'sub': 1', '2', '1', '2, 'a. at least a portion of said at least one region of mucosal tissue is at least temporarily maintainable at a predetermined temperature range Twhile another at least a portion of said at least one region of said mucosal tissue is at least temporarily maintainable at predetermined temperature range T, where Tis equal to or different from T;'}b. said device additionally comprises at least one temperature sensor adjacent to at least one of said plurality of electrodes;c. said at least one region of mucosal tissue is within a vagina; andd. said device additionally comprises a processor in communication with said at least one temperature sensor, said at least one temperature sensor is selected from a group consisting of: a thermistor, a thermocouple and any combination thereof3. The device of claim 2 , wherein at least one of the following is being held true:a. ...

Esthetic apparatus useful for increasing skin rejuvenation and methods thereof

The present invention provides a device for rejuvenating a region of skin or mucosal tissue, comprising: a pulsed electromagnetic frequency generator; a plurality of electrodes in communication with the pulsed electromagnetic frequency generator and an RF tissue diathermy device. The electrodes apply the pulsed electromagnetic power and the RF tissue diathermy to the tissue, heating it such that one portion of the region of mucosal tissue is maintained at a predetermined temperature range T 1 while another portion of the region of mucosal tissue is at least temporarily maintained at predetermined temperature range T 2 .

ACCESS GATE OR GANTRY COMPRISING AN ANTENNAS ASSEMBLY FOR THERAPY OR IMAGING

The present invention relates to an access gate or gantry—antennas assembly for a therapeutical equipment or for an imaging equipment, particularly for an oncological hyperthermia system. In particular, said assembly comprises an access gate or gantry (), an array of first antennas () coupled with said gantry (), a bed (), said bed being at least longitudinally movable with respect to said gantry (), and at least one second antenna (A), provided in said bed, where said assembly comprises lifting and lowering means (A) for lifting and lowering said access gate or gantry. 12324222. Access gate or gantry—antennas assembly for a therapeutical equipment or for an imaging equipment , particularly for an oncological hyperthermia system , said assembly comprising an access gate or gantry () , an array of first antennas () coupled with said gantry () , a bed () , said bed being at least longitudinally movable within respect to said gantry () , and at least one second antenna provided in said bed , said assembly being characterized in that it comprises lifting and lowering means (A) for lifting and lowering said access gate or gantry ().235622. Assembly according to the preceding claim , characterized in that each of said first antennas () is provided with translation means ( , ) for translating with respect to the inner part of said gantry () , and rotation means for rotating with respect to the gantry () itself.3. Assembly according to the preceding claim , characterized in that{'b': 3', '3', '2', '36', '3', '3, 'each first antenna () comprises a first shell (A), coupled with said gantry (), and a second shell (), coupled with said first shell (A) and arranged within said first shell (A),'}in that{'b': 5', '6', '3, 'said translation means (, ) are configured to translate said second shell (B) in a first direction of a predetermined distance, and'}in that{'b': 7', '3', '3', '3', '3', '3', '3', '3', '2', '7, 'said rotation means () are configured to rotate said first shell (A ...

Hyperthermia Electromagnetic Energy Applicator Housing and Hyperthermia Patient Support System

EMR applicators of an EMR applicator array are provided in an openable applicator housing to allow easy patient entrance to and exit therefrom so that the portion of the patient's body that contains the tissue to be treated can be positioned directly into the applicator housing without the applicator housing having to be moved along the patient's body. This can eliminate or reduce the need for full body supporting structure as part of the applicator housing. The applicator housing provides support for the portion of the body positioned therein, and support pads or pillows, separate from the applicator housing, can replace the need for a full body support as part of the applicator housing. The housing can reduce the size and complication of prior art applicator housings, and can be placed along with the patient, on a patient support surface, such as in a standard MRI system. 1. An electromagnetic energy applicator housing for positioning an array of electromagnetic energy applicators around an opening adapted to receive a portion of a patient body having tissue therein in need of hyperthermia treatment , wherein the electromagnetic energy applicator housing can move between an open condition to directly receive a portion of the portion of the patient body having the tissue therein in need of hyperthermia treatment and a closed condition for treatment , comprising:a lower housing shell forming an inner lower concave surface and having opposite lower housing shell sides and opposite lower housing shell ends;a lower bolus extending from the inner lower concave surface of the lower housing shell and adapted to be filled with a dielectric fluid, said lower bolus having a lower bolus surface spaced from the inner lower concave surface when filled with a dielectric fluid and adapted to receive a portion of the portion of the patient body having tissue therein in need of hyperthermia treatment when the portion of the patient body having tissue therein in need of hyperthermia ...

Ultrasound apparatuses for thermally-induced renal neuromodulation and associated systems and methods

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

HEATING/SENSING CATHETER APPARATUS FOR MINIMALLY INVASIVE APPLICATIONS

Catheter apparatus comprises a coaxial cable having proximal and distal ends. The cable includes a hollow center conductor, an outer conductor and an electrically insulating layer between the conductors. An antenna is at the distal end of the cable, and a diplexer is connected to the cable, the diplexer including a transmit path for connecting the antenna to a transmitter which transmits first frequency signals and a receive path for connecting the antenna to a receiver which detects second frequency signals the diplexer isolating the signals on the two paths from one another. A transmission line connects the cable to the diplexer, the transmission line having a segment with a tubular inner conductor one end of which is connected to the center conductor and a second end of which is adapted for connection to a coolant source, the center and inner conductors forming a continuous coolant pathway. 1. Catheter apparatus comprisingan elongated flexible coaxial cable having proximal and distal ends, said cable including a hollow center conductor, an outer conductor and an electrically insulating layer in an annular space between said conductors;an antenna at the distal end of the cable;a diplexer including a transmit path for connecting the antenna to a transmitter which transmits signals of a first frequency and a receive path for connecting the antenna to a receiver which detects signals of a second frequency, said diplexer isolating the signals on the two paths from one another;a transmission line connecting the cable to the diplexer, said transmission line including a segment with a tubular inner conductor one end of which is connected to the center conductor of the cable and a second end of which is adapted for connection to a coolant source, said center conductor and said inner conductor forming a continuous coolant pathway.2. The apparatus defined in wherein said receive path includes a first electrical filter.3. The apparatus defined in whereinsaid first filter ...

METHODS AND SYSTEMS FOR CONTROLLING MAGNETIC FIELDS AND MAGNETIC FIELD INDUCED CURRENT

The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain. The system is configured such that the DC magnetic fields may be used to manipulate the transient magnetic fields, in turn allowing significantly improved control and focus of the induced current within a specifically desired volume of interest within a patient's body. 1. A system for controlling magnetic fields and induced currents in a target volume inside a brain of a human or animal , the system comprising:(a). an array of magnetic coils disposed on an external housing, the array comprising:a first set of coils configured to generate a DC magnetic field in the brain; anda second set of coils configured to generate transient magnetic fields inducing a plurality of currents in the brain matter;(b). a power source; and(c). a control system;wherein the target volume is smaller than 20% of the brain volume and is disposed at least 2 cm deep under the brain surface;wherein the currents induced in the target volume are large enough such as to trigger neuronal firing in more than 75% of the target volume;wherein the currents induced outside the target volume are small enough such as not to trigger neuronal firing in more than 5% of the brain matter outside ...

IMPEDANCE-BASED POSITION TRACKING PERFORMANCE USING SCATTERED INTERPOLANT

A method includes, receiving from a calibration probe multiple data points acquired in an organ of a patient, each data point including (i) a respective position of the calibration probe, and (ii) a respective set of electrical values indicative of respective impedances between the position and multiple electrodes attached externally to the patient. A mapping between sets of the electrical values and respective positions in the organ is constructed, by performing for each received data point: if the mapping already contains one or more existing data points in a predefined vicinity of the data point, the one or more existing data points are adjusted responsively to the received data point, and if the predefined vicinity does not contain any existing data points, the received data point is added to the mapping. A position of a medical probe is subsequently tracked in the organ using the mapping. 1. A method , comprising:receiving from a calibration probe multiple data points acquired in an organ of a patient, each data point comprising (i) a respective position of the calibration probe, and (ii) a respective set of electrical values indicative of respective impedances between the position and multiple electrodes attached externally to the patient; if the mapping already contains one or more existing data points in a predefined vicinity of the data point, adjusting the one or more existing data points responsively to the received data point; and', 'if the predefined vicinity does not contain any existing data points, adding the received data point to the mapping; and, 'constructing a mapping between sets of the electrical values and respective positions in the organ, by performing for each received data pointsubsequently, tracking a position of a medical probe in the organ using the mapping.2. The method according to claim 1 , wherein constructing the mapping comprises finding the one or more existing data points that fall in the predefined vicinity claim 1 , by ...

SYSTEM AND METHOD FOR TREATING SCAR TISSUE OF A BIOLOGICAL SUBJECT USING RADIO FREQUENCY WAVES AND MANIPULATION

A system and method for treating tissue of a biological subject, including a radio frequency wave generator configured for generating a radio frequency wave at a therapeutically beneficial wavelength, a power supply configured for supplying power to the generator for generation of the wave, a controller configured for setting the wavelength, and a director configured for directing the wave to the tissue to achieve a therapeutically beneficial outcome for the subject. Preferably, the wave generates heat at a therapeutically beneficial temperature. Preferably, the director is configured for directing the wave to the tissue by placement of the director adjacent the tissue and movement of the director across the tissue in alternating general directions applied at various therapeutically beneficial speeds, various therapeutically beneficial distances, and various therapeutically beneficial time intervals within a desired treatment area of the tissue. 1. A system for treating tissue of a biological subject , comprisinga radio frequency wave generator;a power supply;a controller; anda director; whereinthe generator is configured for generating a radio frequency wave at a therapeutically beneficial wavelength;the power supply is configured for supplying power to the generator for generation of the wave;the controller is configured for setting the wavelength;the director is configured for directing the wave to the tissue; anddirecting the wave to the tissue at the wavelength achieves a therapeutically beneficial outcome for the subject.2. The system of claim 1 , wherein the wave generates heat at a therapeutically beneficial temperature.3. The system of claim 2 , wherein the temperature is one or more of inclusively between 35 and 55 degrees Celsius claim 2 , 40 and 50 degrees Celsius claim 2 , and 41 and 48 degrees Celsius.4. The system of claim 2 , wherein the temperature is determined based on a depth of the tissue.5. The system of claim 1 , wherein the director is ...

Methods and Devices for Stimulating an Immune Response Using Nanosecond Pulsed Electric Fields

Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject. 1. A method for stimulating an immune response to a disease in a subject , the method comprising:determining a target treatment energy based on a size and a type of a tumor in the subject;selecting or allowing selection of a number of pulses, an amplitude of at least 10 kilovolts per centimeter, or a pulse length of between 0.1 nanoseconds and 1000 nanoseconds for sub-microsecond pulsed electric fields based on the determined target treatment energy; andapplying to the tumor, using a plurality of electrodes positioned in or around the tumor or a portion thereof, the sub-microsecond pulsed electric fields having the selected number of pulses, the selected amplitude, or the selected pulse length.2. The method of further comprising:adjusting the target treatment energy based on a comparison of a measured immune response biomarker before the applying and a measured immune response biomarker after the applying in a sample of the subject;determining a new number of pulses, a new amplitude, or a new pulse length based on the adjusted target treatment energy; and 'applying to the tumor, using the plurality of electrodes, sub-microsecond pulsed electric fields based on the ...

APPARATUS AND COSMETIC METHOD FOR TREATING HYPERHIDROSIS

A cosmetic method for treating a human body to reduce hyperhidrosis includes applying laser light energy to one or more portions of the human body in which the laser light energy is one or more of: about 450 nm, about 930 nm, about 970 nm and about 1060 nm. An apparatus for accomplishing this method includes a source of laser light energy and a controller for controlling the laser light source to apply laser light energy to target and disrupt sweat glands in the human body. 1. A cosmetic method of treating a human body to reduce hyperhidrosis comprising: applying laser light energy to one or more portions of the human body wherein the laser light energy is one or more of: about 450 nm , about 930 nm , about 970 nm and about 1060 nm.2. The cosmetic method of claim 1 , wherein the laser light energy is delivered one of: continuous or pulsed.3. The cosmetic method of claim 2 , wherein the pulse rate is 1 Hz.4. The cosmetic method of claim 2 , wherein the pulse rate is selected from between ½ Hz and 3 Hz.5. The cosmetic method of claim 1 , further comprising the step of cooling the human body in the vicinity of the application of the laser light energy.6. The cosmetic method of claim 2 , wherein the time delay between pulses is between the TRT of fat cells and the TRT of sweat glands.7. A cosmetic method of treating a human body to reduce hyperhidrosis comprising: applying laser light energy to one or more portions of the human body wherein the laser light energy is provided as bulk heating of the skin surface of the human body.8. The cosmetic method of further comprising the step of providing bulk heating of the skin surface of the human body one or more of: before claim 1 , during and after the application of the laser light energy.9. The cosmetic method of claim 8 , wherein the bulk heating is provided by one or more of: laser light energy claim 8 , IPL light energy claim 8 , RF energy claim 8 , microwave energy or ultrasonic energy.10. The cosmetic method of claim 8 ...

Esthetic apparatus useful for increasing skin rejuvenation and methods thereof

Systems and methods for increasing skin rejuvenation of a region of a patient's skin. The system includes: a pulsed electromagnetic field (PEMF) frequency generator that emits electromagnetic pulses to the region of the patient's skin; and a deep tissue diathermy device that applies heat to the region of the patient's skin up to temperature T. The system simultaneously applies the heat and the PEMF to the region of a patient's skin.

CONTROLLED STIMULATION DEVICE

A controlled stimulation device used either alone or in conjunction with a treatment device to reduce amount of pain a patient may experience during a treatment with the treatment device.

WIRELESS NEURAL STIMULATOR WITH INJECTABLE

Neural stimulator systems with an external magnetic coil to produce changing magnetic fields is applied outside the body, in conjunction with one or more tiny injectable objects that concentrates the induced electric field to a highly-targeted location. These systems include a driver circuit for the magnetic coil that allows for high voltage and fast pulses in the coil, while requiring low-voltage power supply that may be powered by a wearable or portable external device, along with the coil and driver circuit. 1. A neuromodulation system , comprising: a housing;', 'a coil;', 'a capacitor connected in parallel with the coil such that a stimulation signal is a portion in time of a resonance between the parallel capacitor and coil;', 'a DC power supply at a first side of the parallel capacitor and coil, and configured to activate the parallel coil and capacitor; and', 'a switch to ground on a second side of the parallel capacitor and coil, wherein the switch comprises a microprocessor, a transistor and a rectifier;', 'wherein the microprocessor is configured to turn off a gate or a base of the transistor just prior to a first series of decaying resonant pulses to provide a free running resonance between the coil and the capacitor and then turn on the gate or the base to build up a current in the magnetic field generator prior to a second series of decaying resonant pulses to reduce electrical energy in the coil between the first and second series., 'an external free running resonance magnetic field generator, comprising2. The neuromodulation system of claim 1 , wherein the magnetic field generator further comprises an adhesive to attach the housing to a location on a human body.3. The neuromodulation system of claim 1 , further comprising a means for attaching the housing to a location on a human body.4. The neuromodulation system of claim 1 , further comprising a battery.5. The neuromodulation system claim 4 , wherein the magnetic field generator further comprises a ...

High-power pulsed electromagnetic field applicator systems

Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with a remote server for patient monitoring, prescription and/or device servicing.

Acoustic therapy device

The present disclosure provides a system for treatment of thrombosis. The system includes a garment configured to secure to a portion of a body of the user and a plurality of energy units, coupled to the garment, that provide energy inside the body of the user to prevent or break-up at least one of thrombin or a clot formation and increase vascular flow.

Esthetic Apparatus Useful for Increasing Skin Rejuvenation and Methods Thereof

Systems and methods for increasing skin rejuvenation of a region of a patient's skin. The system includes: a pulsed electromagnetic field (PEMF) frequency generator that emits electromagnetic pulses to the region of the patient's skin; and a deep tissue diathermy device that applies heat to the region of the patient's skin up to temperature T. The system simultaneously applies the heat and the PEMF to the region of a patient's skin.

HEATING APPARATUS AND METHODS

A medical inductive heating apparatus () for heating at least a portion of a prosthetic or implant. The apparatus () has at least one external induction coil, the external induction coil being external to a body or housing of the apparatus (). The coil () is sized and dimensioned to be smaller than a body portion associated with the prosthetic or implant. 142.-. (canceled)43. A medical inductive heating apparatus configured for heating at least a portion of a prosthetic or implant to a temperature and for a time suitable for reducing the active count of invasive cell species forming a biofilm , the apparatus comprising at least one external induction coil , the external induction coil being external to a body or housing of the apparatus , wherein the coil is sized and dimensioned to be smaller than a body portion associated with the prosthetic or implant.44. The apparatus of claim 43 , wherein the apparatus is configured to heat the portion of the prosthetic or implant to a temperature from about 38° C. to about 120° C. claim 43 , preferably of from about 60° C. to about 90° C. claim 43 , in particular of from 65° C. to 70° C. claim 43 , for a period of time suitable to reduce the active count of invasive cell species forming a biofilm.45. The apparatus of claim 43 , wherein the apparatus is configured to position the coil closer to the portion of the prosthetic or implant than a diameter of the coil.46. The apparatus of claim 43 , wherein the coil is preferably configured for insertion into or through a surgical incision.47. The apparatus of claim 43 , wherein the apparatus comprises a portable claim 43 , handheld apparatus configured for single-handed use by a user claim 43 , the apparatus comprising a pistol grip handle with an actuator for operation by the gripping hand.48. The apparatus of claim 43 , wherein the apparatus is configured to provide an operating frequency of a Pulsed Electromagnetic Field (PEMF) of less than about 100 kHz.49. The apparatus of ...

Apparatus and Method for Creating Small Focus Deep Hyperthermia In Tissues of the Brain

A radio frequency annular phased array hyperthermia system providing a heated focal zone with a diameter of 3 cm or less in a tissue mass includes a plurality of at least 42 radio frequency energy applicators in three rings adapted to surround the tissue mass. A bolus having a dielectric constant is positioned between the energy applicators and the tissue mass. The energy applicators operate at a frequency of at least about 900 MHz. to create the heated focal zone. The circumferential spacing between adjacent applicators in each ring is less than a critical distance and spacing between adjacent side by side rings is also less than a critical distance with such critical distances being interdependent on the frequency of the energy radiated, the dielectric constant of the bolus, the size of the bolus, and the size of the tissue mass. 1. A radio frequency annular phased array hyperthermia system to provide a heated focal zone of diameter of about 3 cm or less in a selected position in a tissue mass , said hyperthermia system comprising:a bolus adapted to be positioned around the tissue mass in which the heated focal zone is to be provided to form an interface with the outer surface of the tissue mass, said bolus having a size and having a bolus media therein with a bolus media dielectric constant;a plurality of radio frequency energy radiator applicators positioned in three rings around the tissue mass in which the heated focal zone is to be provided and spaced by the bolus media a distance from the surface of the tissue mass, each radio frequency energy radiator applicator operable to radiate radio frequency signals of a predetermined frequency of 900 MHz or above through the bolus media into the tissue mass wherein the electric field of the radiated signals from each radio frequency energy radiator applicator are superimposed in a controlled manner to produce the heated focal zone in the selected position in the tissue mass, each radio frequency energy radiator ...

Multi-Electrode Apposition Judgment Using Pressure Elements

Apparatus and methods for determining positioning of a energy delivery element include deploying a energy delivery element at a treatment site proximal to a vessel wall; using a multi-region pressure sensing apparatus to sense pressures applied in a plurality of directions about the energy delivery element; and determining an orientation of the energy delivery element based on the pressures measured in the plurality of directions about the energy delivery element. 1. An apparatus for measuring blood pressure of a patient during a neuromodulation treatment , comprising:a therapeutic assembly configured for intravascular delivery to a treatment site;an energy delivery element disposed on the therapeutic assembly and configured to be positioned against a vessel wall to deliver neuromodulation energy at the treatment site; anda pressure sensor having a plurality of pressure sensitive regions, the pressure sensor being configured to measure the blood pressure of the patient.2. The apparatus of claim 1 , wherein the pressure sensor includes a first conductive annular ring claim 1 , a second conductive annular ring and a plurality of non-conductive areas on the second conductive annular ring.3. The apparatus of claim 1 , wherein the plurality of pressure sensitive regions are configured to sense pressure in a plurality of directions about the energy delivery element.4. The apparatus according to claim 1 , wherein the energy delivery element includes a plurality of energy delivery elements.5. The apparatus according to claim 1 , wherein the pressure sensor includes a capacitive pressure sensor.6. The apparatus according to claim 1 , wherein the therapeutic assembly includes an elongated support structure configured to take a pre-determined shape upon deployment in a vessel claim 1 , wherein the energy delivery element is disposed in a predetermined orientation on the elongated support structure.7. The apparatus according to claim 6 , wherein the elongated support structure ...

PULSE SOURCE AND METHOD FOR MAGNETICALLY INDUCTIVE NERVE STIMULATION

The invention relates to a modular pulse source consisting of a main module and at least one additional module which are connected in series to each other in the sense of two-terminal circuits. The modules each comprise an energy storage device. The energy storage device of the main module is initially charged by a charging circuit. A stimulation coil is connected at the two ends of the series connection and as a result of a voltage pulse delivered by the chain of modules generates a magnetic field which in turn causes an induced electrical pulse or a respective electric field. 1. Pulse source for the application of induced electrical pulses in the medical field , with a modular pulse source for generating voltage pulses having a controllable temporal course , a stimulation coil connected to said modular pulse source for generating a magnetic field due to the voltage pulses acting upon the stimulation coil , for generating induced electrical pulses , and a charging circuit ,said modular pulse source comprising:at least one main module to be charged by way of said charging circuit,n−1 further modules, where n is an integer and n≥2 is true,where all at least n modules are connected to each other in series by way of their module terminals,where each modules comprises an energy storage device, preferably a capacitor for storing charge, and each module comprises switching devices, preferably formed by transistors, for selective and controlled setting of at least one active normal operation, in which said respective module introduces the voltage at its energy storage device into the voltage path of said series connection, and a bypass operation, in which said respective module only connects through the voltage path of said series connection, and preferably an inverted operation, in which the respective module introduces the voltage at its energy storage device inverted into said serial voltage path,a controller device for directly or indirectly detecting the states of ...

DEVICES AND METHODS FOR NON-INVASIVE VAGAL NERVE STIMULATION

Devices and methods for non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode spaced from the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is positioned within the housing and operably coupled to the electrode, either wirelessly or via a lead or other wired connection. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses. 1. A method comprising:positioning an electrode adjacent to, or in contact with, an outer skin surface of a patient;generating an electrical impulse within a housing spaced from the electrode, wherein the electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses; andtransmitting the electrical impulse from the housing to the electrode such that the electrical impulse passes through the outer skin surface to a target region in the patient, wherein the electrical impulse is sufficient to modulate a nerve in the target region.2. The method of claim 1 , further comprising transmitting the electrical impulse from the housing to the electrode via a lead claim 1 , wherein the electrode is removably coupled to the lead.3. The method of claim 1 , further comprising wirelessly transmitting the electrical impulse from the housing to the electrode.4. The method of claim 1 , wherein each of the pulses has a duration of about 50 microseconds to about 1000 microseconds.5. The method of claim 1 , further comprising positioning the electrode on an outer skin surface of a neck of the patient and transmitting the ...

Applying Tumor Treating Fields (TTFields) Via Electrodes Embedded into Skull Implants

Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates. 1. An apparatus comprising:a rigid substrate shaped and dimensioned to replace a section of a skull, the substrate having an inner side and an outer side;an electrically conductive plate having an inner side and an outer side, wherein the outer side of the plate is affixed to the inner side of the substrate;a dielectric layer disposed on the inner side of the plate; andan electrically conductive lead having an inner end and an outer end, wherein the inner end of the lead is disposed in electrical contact with the plate, wherein the lead passes through the substrate, and wherein the outer end of the lead is configured to accept an electrical signal from an external device.2. The apparatus of claim 1 , further comprising a temperature sensor positioned adjacent to the dielectric layer.3. The apparatus of claim 2 , further comprising at least one wire that passes through the substrate and terminates at the temperature sensor claim 2 , wherein the wire is configured to transmit an electrical signal from the temperature sensor to the external device.4. The apparatus of claim 3 , wherein the temperature sensor comprises a thermistor.5. The apparatus of claim 1 , wherein the ...

SYSTEM AND METHOD FOR A PHYSIOCHEMICAL SCALPEL TO ELIMINATE BIOLOGIC TISSUE OVER-RESECTION AND INDUCE TISSUE HEALING

Removal of damaged tissue itself can enable biosynthetic activity in vivo as an unburdened homeostatic or repair response. By removing a biologic and mechanical irritant, the lesion site can be altered to a more favorable perturbation-specific mechanotransductive environment supportive of differentiated gene expression. One aspect of one embodiment of the present invention provides an engineered irrigant that produces ion exchanges in tissues for example deliver of protons which interact with biology tissues. 1. A method for treating targeted tissue comprising:localizing an alternating current circuit device tip having electrodes in a conductive solution containing electroactive species in which a targeted tissue of a host is found;deploying current to the alternating current circuit device tip located in close proximity to the targeted tissue wherein the device tip inhibits electrode-to-tissue contact but permits a shielded reaction zone for the conductive solution to react with at least one electrode of the alternating current circuit device tip;moving an electron between electrodes of the alternating current circuit device tip utilizing an electron donor and acceptor carrier within the conductive solution containing electroactive species;producing an electromagnetic field quanta near the targeted tissue when the device tip is placed next to the targeted tissue and producing an electron donor and an electron acceptor carrier associated with a charged specie intermediary created in the conductive solution formed above a baseline dissociation rate;moving the charged specie intermediary created in the conductive solution toward the targeted tissue surface; andinducing an effect upon the targeted tissue or the conductive solution that is configured to treat the targeted tissue.2. The method of wherein the effect is produced by inducing gene expression with energy that is not injury inducing to the targeted tissue.3. The method of wherein the effect is produced by ...

ENERGY-DELIVERY SYSTEM AND METHOD FOR CONTROLLING BLOOD LOSS FROM WOUNDS

An energy delivery system for controlling blood loss is provided. The system includes an energy-activated patch configured for placement on tissue. The patch includes an energy-delivering layer configured to deliver energy to the tissue. The system also includes an energy source in operative engagement with the energy-activated patch for energizing the energy-delivering layer. 1. (canceled)2. An energy delivery system for delivering energy to a wound and controlling blood loss by promoting coagulation of the blood thus sealing the wound , the system comprising:an energy-activated patch configured for placement on tissue in proximity to the wound, the patch includes an energy-delivering layer configured to deliver energy to the wound to promote coagulation of the blood thus sealing the wound, the energy-delivering layer including a grid of active and return RF electrodes; andan energy source in operative engagement with the energy-activated patch, the energy source configured to energize the grid of active and return RF electrodes to activate the energy-activated patch.3. The energy delivery system according to claim 2 , wherein the patch further includes an energy-activated gel layer in proximity to the energy-delivering layer.4. The energy delivery system according to claim 3 , where the energy-activated gel layer includes a coagulant.5. The energy delivery system according to claim 3 , wherein the energy-activated gel layer includes a medicament.6. The energy delivery system according to claim 4 , wherein the energy-activated patch further includes a tissue support layer in proximity to the energy-activated gel layer.7. The energy delivery system according to claim 6 , wherein the tissue support layer includes a bio-material.8. The energy delivery system according to claim 2 , wherein the energy-activated patch further includes a barrier layer in proximity to the energy-delivering layer.9. The energy delivery system according to claim 4 , wherein the energy- ...

Methods and apparatus for treatment of chronic kidney disease

A method and apparatus for treatment of chronic kidney disease (CKD), particular diabetic nephropathy, are disclosed. The method comprises activation of adenosine A2a receptors in parenchymal and immune cells infiltrated into kidneys. The activation is performed by PEMF (pulsed electromagnetic field) stimulation applied locally to kidneys. Adenosine A2a signaling pathway is a potent anti-inflammatory and immuno-suppressive regulator that has been proven to attenuate inflammation and injury in diabetic nephropathy. Efficient activation of A2a receptors is achieved by applying electromagnetic field stimulation consecutively in 3 spatial dimensions. This allows attaining a significant increase in activation of A2a receptors in comparison with one-dimensional stimulation. Assistant thermal stimulation may be applied to increase expression of heat shock proteins (HSPs) in parenchymal cells. HSPs improve protein functions, protect cells from apoptosis and necrosis, increase metabolism, and symbiotically enhance effects of electric stimulation on CKD.

NONINVASIVE THERAPIES IN THE PRESENCE OF EXOGENOUS PARTICULATE AGENTS

Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications. 1: A method for treating organs and/or tissues comprising:applying electromagnetic radiation at one or more frequencies selected from a range of frequencies from and including a radio-frequency energy to and including an infrared energy in the presence of particulate enhancing agents introduced into the organs and/or tissues, wherein the particulate enhancing agents absorb the electromagnetic energy and comprise a metal.2: The method of claim 1 , wherein the metal is selected from the group consisting of gold claim 1 , silver claim 1 , platinum and combinations thereof.3: The method of claim 1 , wherein the electromagnetic energy is tuned to the organs and/or tissues being treated according to a set of parameters including one or more of frequency claim 1 , pulse duration claim 1 , pulse repetition rate claim 1 , treatment duration claim 1 , amplitude and field properties of the electromagnetic radiation.4: The method of claim 1 , wherein the electromagnetic energy is tuned to the organs and/or tissues being treated according to a mode of radiation selected from continuous claim 1 , pulsed claim 1 , variable and mixtures thereof.5: The method of claim 1 , wherein the electromagnetic energy is tuned to the particulate enhancing agents according to a set of parameters including one or more of frequency claim 1 , pulse duration claim 1 , pulse repetition rate claim 1 , treatment duration claim 1 , amplitude claim 1 , and field properties of the electromagnetic radiation.6: The method of claim 1 , wherein the electromagnetic energy is tuned to the particulate enhancing agents according to a mode of radiation selected from continuous claim 1 , pulsed claim 1 , ...

Instrument For Therapeutically Cytotoxically Ablating Parathyroidal Tissue Within A Parathyroid Gland

An instrument for therapeutically cytotoxically ablating parathyroidal tissue is disclosed. A substance is capable of transforming the parathyroid gland from overproduction of parathyroid hormone when the substance's quantity exceeds a set amount, and is capable of transforming the parathyroid gland from overproduction only when activated by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the substance's quantity is below the set amount. A delivery device is operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity to below the set amount. An energy device is operable to apply units of the electromagnetic energy after the substance has been introduced. A sensor is operable to monitor the activation of the substance as the electromagnetic energy is applied. The energy device is further operable to modulate applying the electromagnetic energy when the substance has been activated. 1. An instrument for therapeutically cytotoxically ablating parathyroidal tissue within a parathyroid gland , comprising:a substance capable of cytotoxic ablation of a parathyroid gland of a living human, wherein the substance alone is capable of transforming the parathyroid gland from overproduction to non-overproduction of parathyroid hormone when a quantity of the substance exceeds a set amount, and the substance is capable of transforming the parathyroid gland from overproduction to non-overproduction of the parathyroid hormone only when activated in the parathyroidal tissue by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the quantity of the substance is below the set amount;a substance delivery device operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity of the substance being introduced to below the set amount;an electromagnetic energy treatment ...

ELECTROMANIPULATION OF CELLS AND OTHER BIOLOGICAL TISSUES BY PULSEDELECTRIC FIELDS AT ELEVATED TEMPERATURES

Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature. 121-. (canceled)22. A method for treatment of biological tissues comprising a target tissue , comprising:causing a temperature of the target tissue to be elevated and maintained at a treatment temperature range which is above a physiological temperature of the biological tissues and at or below about 47° C.;generating, during the causing, an electric field extending through at least a portion of the target tissue using a pre-defined sequence of short duration voltage pulses applied between at least two electrodes; andsynchronizing maintaining of the treatment temperature range to overlap with applying the pre-defined sequence of short duration voltage pulses, andwherein the pre-defined sequence of short duration voltage pulses is selected such that a magnitude of the electric field is configured to deliver an electrical energy sufficient to induce cell death in the portion of the target tissue at the treatment temperature range and that is lower than a specific electrical energy sufficient to induce cell death in the portion of the target tissue at or below the physiological temperature.23. The method of claim 22 , wherein the treatment temperature range is ...