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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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26-01-2012 дата публикации

Method For Operating A Medical Robot, A Medical Robot, And A Medical Workstation

Номер: US20120022552A1

Автор: Thomas Neff

Принадлежит: KUKA LABORATORIES GmbH

A method for operating a medical robot, a medical robot, and a medical work station. The invention relates to a method for operating a medical robot ( 2 ). The robot ( 2 ) includes a robot arm ( 5 ) having a plurality of members ( 7 ), drives ( 15 ) provided for moving the members ( 7 ), and an attaching device ( 9 ). The robot ( 2 ) also has a control device ( 6 ) for activating the drives ( 15 ), and a sound generating device ( 3 ) attached to the attaching device ( 9 ), which is provided to apply sound to a living organism ( 10 ), in particular a high-intensity focused ultrasound.

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Номер записи: 1

02-02-2012 дата публикации

Ultrasound device for medical applications

Номер: US20120029352A1

Автор: Michael Clossen-Von Lanken Schulz

Принадлежит: SIEMENS AG

An ultrasound device for medical application has a transducer formed by a number of transducer elements. The transducer elements are carried on a flexible support that allows the transducer elements to be configured to an examination subject. A measurement device determines, for each transducer element, a distance or a rotation thereof with respect to a reference point. The reference point can be a point that is physically a part of the ultrasound device, or can be a virtual reference point.

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Номер записи: 2

02-02-2012 дата публикации

Compact ultrasound transducer assembly and methods of making and using the same

Номер: US20120029393A1

Автор: Warren Lee

Принадлежит: General Electric Co

A compact ultrasound transducer assembly is provided. The ultrasound transducer assembly comprises a compact housing, a therapy transducer disposed in the compact housing, and an interchangeable Fresnel lens having a flat surface and a structured surface. The Fresnel lens is disposed in the compact housing so that the flat surface of the Fresnel lens faces the therapy transducer. The structured surface of the Fresnel lens is disposed in a direction away from the therapy transducer, and the Fresnel lens is removably coupled to the therapy transducer, the compact housing, or both.

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Номер записи: 3

08-03-2012 дата публикации

Method and system for ultrasound treatment with a multi-directional transducer

Номер: US20120059288A1

Автор: Michael H. Slayton, Peter G. Barthe

Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.

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Номер записи: 4

05-04-2012 дата публикации

Method for changing an individual's state of consciousness

Номер: US20120083647A1

Автор: Harry Scheinin, Jaakko Langsjo, Kimmo KASKINORO, Michael Alkire

Принадлежит: Individual

This invention concerns a method for altering an individual's level of consciousness by directing stimulation or inhibition to a CNS locus target region in the individual's brain that is responsible for consciousness.

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Номер записи: 5

05-04-2012 дата публикации

Hands-Free Operator-Independent Transcranial Ultrasound Apparatus and Methods

Номер: US20120083718A1

Автор: Anthony J. Alleman, Randal Lee RADFORD, William Barnard

Принадлежит: Cerevast Therapeutics Inc

Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.

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Номер записи: 6

19-04-2012 дата публикации

Ultrasound transducer and cooling thereof

Номер: US20120095371A1

Автор: Ariel Sverdlik, Or Shabtay

Принадлежит: Cardiosonic Ltd

An ultrasonic transducer device for producing ultrasonic beams comprises a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused, or alternatively a focused, power beam for tissue ablation, the power beam being produced by vibration over the body of the transducer and emanating from the extent of the surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.

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Номер записи: 7

03-05-2012 дата публикации

Apparatus and method for ultrasonic spine treatment

Номер: US20120109019A1

Автор: Craig P. Conner, Daniel J. Lee, Daniel R. Bullis, F. Javier De Ana, Jin (NMI) Zhang, John B. Schneider, Kevin J. Tanis, Mark W. Cors, Neill M. Pounder, Nicholas S. Reback, Rachel E. Desmidt, Stephen A. Latham

Принадлежит: Smith and Nephew Inc

The present invention relates to an apparatus for therapeutically treating bone structure using ultrasound, and more particularly, the present invention relates to an apparatus with an attachment structure for treating bone injuries or a variety of musculoskeletal injuries and/or problems.

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Номер записи: 8

17-05-2012 дата публикации

Catheter guidance of external energy for renal denervation

Номер: US20120123243A1

Автор: Roger Hastings

Принадлежит: Boston Scientific Scimed Inc

An in vivo apparatus includes a flexible shaft having a proximal end, a distal end, and a length sufficient to access a patient's renal artery relative to a percutaneous access location. An energy guide apparatus is provided at the distal end of the shaft and dimensioned for deployment within the renal artery. An ex vivo apparatus includes an arrangement configured to localize the energy guide apparatus within the renal artery, and an energy source configured to direct ablative energy to target tissue located a predetermined distance from the localized energy guide apparatus. The target tissue includes perivascular renal nerve tissue adjacent the renal artery.

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Номер записи: 9

17-05-2012 дата публикации

Minimally Invasive Access for Renal Nerve Ablation

Номер: US20120123303A1

Автор: David Sogard, Mark L. Jenson, Scott Smith

Принадлежит: Boston Scientific Scimed Inc

An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.

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Номер записи: 10

24-05-2012 дата публикации

Ultrasound detecting device having function of confirming irradiation position, and method thereof

Номер: US20120130240A1

Автор: Atsushi Asahina, Jun Takeda, Naoko Sakamoto

Принадлежит: Teijin Pharma Ltd

Provided is an ultrasound fracture detection device capable of accurately irradiating an ultrasound pulse to a target object, the device being characterized by being provided with an ultrasound wave irradiating transducer, a signal receiving transducer which receives a reflected wave of an ultrasound wave irradiated from the ultrasound wave irradiating transducer, a signal, storage unit which stores a received signal, and a display unit which displays an analysis program that analyzes a stored signal, a determination program that performs determination from the result of the analysis and/or performs determination from the stored signal, and the result of the analysis and/or the result of the determination, wherein the determination program performs the determination using that information relating to the received signal varies depending on the reflector within a living organism.

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Номер записи: 11

31-05-2012 дата публикации

Method and apparatus for treatment of adipose tissue

Номер: US20120136282A1

Автор: Avner Rosenberg, Michael Kreindel, Shimon Eckhouse

Принадлежит: SYNERON MEDICAL LTD

The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

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Номер записи: 12

21-06-2012 дата публикации

Systems and methods for automatically identifying and segmenting different tissue types in ultrasound images

Номер: US20120157842A1

Автор: Cynthia Elizabeth Landberg Davis, Gokul Swamy, Hae Won Lim, Navneeth Subramanian, Nitya Subramaniam, Ying Fan

Принадлежит: General Electric Co

A system for providing non-invasive ultrasound based treatment to a region of interest is provided. The system comprises an imaging unit for imaging one or more tissue types in the region of interest, an image processing unit that is configured to identify the one or more tissue types in the region of interest, an ultrasound transducer that is configured to focus an ultrasound beam to ablate at least a portion of the identified tissues, and a controller unit that controls a delivery of the ultrasound beam to the region of interest.

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Номер записи: 13

05-07-2012 дата публикации

Mr imaging guided theraphy

Номер: US20120172708A1

Автор: Ajay Anand, Balasundara Iyyavu Raju, Gösta Jakob Ehnholm

Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

The invention relates to a therapeutic system which comprises an ultrasound therapy unit ( 1, 518 ) arranged to insonify at least a portion of a body ( 2, 508 ) of a patient with high intensity ultrasound and a MR imaging unit ( 3, 500 ) arranged to acquire MR signals from the portion of the body ( 2, 508 ) and to reconstruct a thermographic MR image from the MR signals. It is an object of the invention to enable MR guided high intensity focused ultrasound (HIFU) treatment, in which temperature values within critical anatomic regions containing fat can be monitored. The invention proposes that the therapeutic system further comprises an ultrasound diagnostic unit ( 5, 518 ) which is arranged to acquire ultrasound signals from the portion of the body ( 2, 508 ) and to derive at least one local temperature value from the ultrasound signals.

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Номер записи: 14

12-07-2012 дата публикации

Ischemic Stroke Therapy

Номер: US20120179073A1

Автор: Henry Nita

Принадлежит: Individual

A method for delivering ultrasound energy to a patient's intracranial space includes the steps of forming a hole in a patient's skull, locating an ultrasound transmitter near or into the hole, and transmitting ultrasound from the transmitter into the intracranial space, wherein the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0, the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW/cm 2 and less than 200 mW/cm 2 , and the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz. Microbubbles, aspirin, both microbubbles and aspirin, and a mixture of microbubbles and aspirin, can also be delivered into the intracranial space.

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Номер записи: 15

02-08-2012 дата публикации

Device for intermittently performing care sessions to form a large skin area care

Номер: US20120197135A1

Автор: Michael Slatkine

Принадлежит: Individual

A device of guiding a multiple area dermatologic care process. The device comprises a carrier which supports a drive of a dermatologic care tool over a skin area while the dermatologic care tool intermittently performs a plurality of dermatologic care sessions each in one of a plurality of skin subareas of the skin area and a brake unit which regulates a movement of the carrier from a first skin subarea to a second skin subarea during the drive of the dermatologic care tool.

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Номер записи: 16

09-08-2012 дата публикации

Ultrasound power supply for an ultrasound transducer

Номер: US20120203098A1

Автор: Balasundara Iyyavu Raju, Shiwei Zhou, Shunmugavelu Sokka

Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

An ultrasound power supply ( 100 ) adapted for supplying electrical power for driving an ultrasound transducer ( 202, 702 ) in contact with a subject ( 208 ), wherein the ultrasound power supply comprises:—a communications interface ( 102 ) adapted for receiving a first temperature measurement of a first volume ( 211, 318 ) of the subject and a second temperature measurement of a second volume ( 214, 320 ) of the subject;—a controller ( 108 ) adapted for modulating the output of electrical power for driving the ultrasound transducer such that via ultrasonic heating by the ultrasound transducer: a. the first temperature measurement is maintained above a first predetermined threshold, b. the first temperature measurement is maintained below a second predetermined threshold, and c. the second temperature measurement is maintained below a third predetermined threshold; and wherein the first predetermined threshold is above the third predetermined threshold.

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Номер записи: 17

23-08-2012 дата публикации

Medical device

Номер: US20120215136A1

Автор: JIN Zhang, John B. Schneider, Richard H. Pearce

Принадлежит: Smith and Nephew Inc

A modular medical device includes a core module housing. The core module housing includes a treatment module interface configured to couple to any one of a plurality of treatment modules, and each of the plurality of treatment modules includes a treatment assembly configured to apply a medical treatment. The core housing module contains one or more processing devices coupled to the treatment module interface and configured to determine which particular treatment module, from the plurality of treatment modules, is coupled to the treatment module interface. The one or more processing devices are configured to select, based on the determination, a set of control instructions for the particular treatment module from a plurality of control instructions, and control the particular treatment module using the selected control instructions such that the treatment assembly of the particular treatment module applies the medical treatment for which the treatment assembly is configured.

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Номер записи: 18

20-09-2012 дата публикации

Nerve treatment system

Номер: US20120238919A1

Автор: Michael Gertner

Принадлежит: Kona Medical Inc

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

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Номер записи: 19

25-10-2012 дата публикации

Energetic modulation of nerves

Номер: US20120271171A1

Автор: Michael Gertner

Принадлежит: Kona Medical Inc

A system to modulate an autonomic nerve in a patient utilizing transcutaneous ultrasound energy delivery includes a processor comprising an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve, and an output for outputting a signal, wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target, a therapeutic energy device comprising a transducer for delivering ultrasound energy from outside the patient, a controller to control an aiming of the transducer based at least in part on the signal from the processor, and an imaging system coupled to the processor or the therapeutic energy device.

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Номер записи: 20

25-10-2012 дата публикации

Apparatus and Method for Ablating Tissue

Номер: US20120271334A1

Автор: Benjamin Pless, David A. Gallup, Jack E. Ulstad, Jr., John E. Crowe, Jonathan L. Podmore, Matthias Vaska, Roxanne L. Richman, Scott C. Anderson, Timothy Ciciarelli

Принадлежит: Individual

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.

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Номер записи: 21

01-11-2012 дата публикации

Dissection handpiece and method for reducing the appearance of cellulite

Номер: US20120277674A1

Автор: Adnan I. Merchant, Ben F. Brian, III, James E. Chomas, Robert L. Clark, Iii

Принадлежит: Cabochon Aesthetics Inc

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

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Номер записи: 22

08-11-2012 дата публикации

Photonic and Thermal Kinetic Energy Therapeutic Device, System and Method

Номер: US20120283603A1

Автор: David B. Sutton, Ronald S. Shapiro

Принадлежит: Shapiro Ronald S, Sutton David B

An apparatus includes a housing having a treatment surface, a light source disposed adjacent the treatment surface and configured to emit dynamic photonic energy, a thermal element disposed adjacent the treatment surface and configured to emit dynamic thermal kinetic energy, and a controller disposed in the housing, the controller in communication with the light source and the thermal element to vary a plurality of parameters of the light source and the thermal element to control the characteristics of the dynamic photonic energy and the dynamic thermal kinetic energy emitted thereby. The treatment surface can also house a variety of sensors that can capture a variety of physical and chemical data, which is integrated with a malleable energy composition and delivery system that co-ordinates with the treatment progress.

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Номер записи: 23

15-11-2012 дата публикации

Ultrasound probe

Номер: US20120285250A1

Автор: Do Kyeong Kim, Ho Jung, Sung Min Rhim

Принадлежит: Humanscan Co Ltd

The present invention relates to an ultrasound therapy system using high-intensity focused ultrasound. The ultrasound therapy improves ultrasound and heat release characteristics and provides an ultrasound probe which easily performs manufacturing and maintenance processes. According to the present invention, a housing is recessed on the inward side around the upper-part edge. A plurality of mounting holes is uniformly formed from the outside at a constant radius to the edge in the center of the upper part. A plurality of probe units is respectively installed in the plurality of mounting holes to form a sphere on the upper part of the housing. And a grounding film covers the sphere which the plurality of probe units forms.

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Номер записи: 24

15-11-2012 дата публикации

Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject

Номер: US20120289761A1

Автор: Edward K. Y. Jung, Edward S. Boyden, Elizabeth A. Sweeney, Eric C. Leuthardt, Lowell L. Wood, JR., Muriel Y. Ishikawa, Roderick A. Hyde, Stephen L. Malaska

Принадлежит: SEARETE LLC

Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.

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Номер записи: 25

15-11-2012 дата публикации

Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject

Номер: US20120289763A1

Автор: Edward K.Y. Jung, Edward S. Boyden, Elizabeth A. Sweeney, Eric C. Leuthardt, Lowell L. Wood, JR., Muriel Y. Ishikawa, Roderick A. Hyde, Stephen L. Malaska

Принадлежит: SEARETE LLC

Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.

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Номер записи: 26

03-01-2013 дата публикации

Low-profile ultrasound transducer

Номер: US20130006153A1

Автор: George K. Lewis, Jr.

Принадлежит: ZETROZ LLC

The present invention relates to a low-profile ultrasound transducer. The low-profile ultrasound transducer includes a piezoelectric component operative to receive a driving signal from an energy generating module and to emit the driving signal as ultrasonic energy. The piezoelectric component has a front surface and a back surface, and the energy generating module includes a plurality of electronic components. The low-profile ultrasound transducer also includes a lens component directly or indirectly deposited on the front surface of the piezoelectric component. The lens component includes a lens portion and a support portion. The lens portion of the lens component is configured to control the direction and wave pattern of the ultrasonic energy emitted from the piezoelectric component. The support portion of the lens component is configured to hold the piezoelectric component in place and to provide a chamber for housing at least one electronic component of the energy generating module. Methods of use and related devices are also disclosed.

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Номер записи: 27

10-01-2013 дата публикации

Methods and systems for ultrasound treatment

Номер: US20130012842A1

Автор: Peter G. Barthe

Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment are provided. Acoustic energy, including ultrasound, can serve as input energy to a mask with apertures, such apertures acting as secondary acoustic sources to create a modulated output acoustic energy in a treatment region and treatment effects. Under proper control output energy can be precisely placed and controlled in tissue. In some embodiments, methods and systems are configured for ultrasound treatment based on creating an output energy distribution in tissue. In some embodiments, methods and systems are configured based on creating an output temperature distribution in tissue.

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Номер записи: 28

24-01-2013 дата публикации

Ultrasonic transducer

Номер: US20130023801A1

Автор: Chunliang Zhao, Deping Zeng, Fangwei Ye, Guihua Xu, Hua Wang, Sanyong Li, Xiaobo Gong, Zhibiao Wang

Принадлежит: Chongqing Haifu Hifu Technology Co Ltd

An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located. The ultrasonic transducer not only can be provided with a large ultrasonic emitting area and a great focusing gain that render the energy of the ultrasonic focus enhanced dramatically, but also can be free from the influence of work frequency of an ultrasonic source.

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Номер записи: 29

07-02-2013 дата публикации

Sparker Array Source

Номер: US20130033968A1

Автор: John Gallagher, Michael Grapperhaus, Raymond B. Schaefer, Robin O. Cleveland

Принадлежит: Phoenix Science and Tech Inc

A sparker array includes a plurality of sparker sources of sound and light emissions, the plurality of sparker sources arranged in a geometric pattern with respect to a region, the array configured to deliver a maximal acoustic output to the region. Sparker sources may include reflectors. A single electrical source to drive a sparker array may be employed. A sparker system may include two or more sparker arrays. A time delay may be employed to trigger electrical circuits of the sparker arrays. Sparker arrays may be used to deliver shock waves with increased operational life, consistency and efficacy for specific applications.

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Номер записи: 30

14-02-2013 дата публикации

Lesion generation through bone using histotripsy therapy without aberration correction

Номер: US20130041293A1

Автор: Charles A. Cain

Принадлежит: University of Michigan

A medical imaging and therapy device is provided that may include any of a number of features. The device may include a Histotripsy transducer, a generator and controller configured to deliver Histotripsy energy from the transducer to target tissue, and an imaging system. In some embodiments, a method of treating tissue with Histotripsy energy comprises positioning a focus of a histotripsy transducer on a target tissue, delivering histotripsy energy from the histotripsy transducer through a bone aberrator, forming a histotripsy bubble cloud on the focus, and preventing the formation of secondary histotripsy bubble clouds without implementing an aberration correction algorithm.

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Номер записи: 31

21-02-2013 дата публикации

Ocular ultrasound probe

Номер: US20130046179A1

Автор: Mark S. Humayun

Принадлежит: Mark S. Humayun

Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.

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Номер записи: 32

21-02-2013 дата публикации

Apparatuses and systems for generating high-frequency shockwaves, and methods of use

Номер: US20130046207A1

Автор: Christopher C. Capelli

Принадлежит: University of Texas System

Apparatuses and methods for generating therapeutic shock waves. Some embodiments comprise: an acoustic-wave generator configured to emit acoustic waves having at least one frequency between 1 MHz and 1000 MHz; a shock wave housing coupled to the acoustic-wave generator; and a shock wave medium disposed in the shock wave housing; where the apparatus is configured such that if the acoustic-wave generator emits acoustic waves then at least some portion of the acoustic waves will travel through the shock wave medium and form one or more shock waves.

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Номер записи: 33

07-03-2013 дата публикации

Dual-Mode Piezocomposite Ultrasonic Transducer

Номер: US20130060140A1

Автор: Yegor Sinelnikov

Принадлежит: Individual

A compact, high power, dual mode, emitting and receiving ultrasound transducer and method for applying ultrasonic energy within a living subject and for monitoring the effects it induces in tissue comprises a set of piezoelectric polymeric transducer elements and a set of piezoelectric ceramic elements, bonded together. The polymeric transducer elements have electrodes enabling their use for low power diagnostic imaging interrogation of the tissue and the ceramic transducer elements have electrodes enabling their use for high power therapy applications.

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Номер записи: 34

07-03-2013 дата публикации

Medical apparatus and method of controlling thereof

Номер: US20130060170A1

Автор: Ho-taik LEE, Hyoung-Ki Lee, Jun-Ho Park, Mun-bo Shim, Won-chul Bang

Принадлежит: SAMSUNG ELECTRONICS CO LTD

A medical apparatus and a method of controlling thereof are provided. The medical apparatus includes an ultrasound transducer unit including a plurality of ultrasound transducer elements, the ultrasound transducer elements being configured to transform signals into ultrasound and output the transformed ultrasound, a grouping unit configured to group the ultrasound transducer elements into a plurality of groups, and a signal generating unit configured to generate the signals to be transformed into the ultrasound and output the generated signals to the groups via a plurality of output channels respectively corresponding to the groups.

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Номер записи: 35

21-03-2013 дата публикации

Ultrasound treatment of sub-dermal tissue for cosmetic effects

Номер: US20130072826A1

Автор: Inder Raj S. Makin, Michael H. Slayton, Peter G. Barthe

Принадлежит: Guided Therapy Systems LLC

A method and system for noninvasive face lifts and tissue tightening are disclosed. The method and treatment system are configured for thermal treatment of Superficial Muscular Aponeurosis System (SMAS) tissue, muscular fascia, or both. In one embodiment, a cosmetic system is configured for treating the SMAS and/or muscular fasica through delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect.

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Номер записи: 36

11-04-2013 дата публикации

Device and methods for renal nerve modulation

Номер: US20130090578A1

Автор: Leonard B. Richardson, Roger N. Hastings, Scott R. Smith

Принадлежит: Boston Scientific Scimed Inc

Systems for nerve modulation are disclosed. An example system may include a first elongate element having a distal end and a proximal end and having at least one transducer disposed adjacent the distal end. The transducer may be an ultrasound transducer. Activation of the transducer may radiate acoustic energy from in two directions simultaneously.

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Номер записи: 37

25-04-2013 дата публикации

Reflectance-facilitated ultrasound treatment and monitoring

Номер: US20130103028A1

Автор: Liat Tsoref, Michael Kardosh, Yossi Gross

Принадлежит: Liat Tsoref, Michael Kardosh, Yossi Gross

Apparatus comprising an ultrasound ablation system ( 10 ), which comprises a reflection-facilitation element ( 12 ), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultra-sound tool ( 20 ), which comprises at least one ultrasound transducer ( 40 ) configured to be positioned within a heart chamber of the subject. The ultrasound transducer ( 40 ) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

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Номер записи: 38

02-05-2013 дата публикации

Targeted inhibition of physiologic and pathologic processes

Номер: US20130110012A1

Автор: Michael Gertner

Принадлежит: Kona Medical Inc

In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

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Номер записи: 39

09-05-2013 дата публикации

Ostial renal nerve ablation

Номер: US20130116687A1

Автор: Martin R. Willard

Принадлежит: Boston Scientific Scimed Inc

A catheter including an elongated shaft having a distal end and a proximal end, where the catheter includes a thermal element at the distal end thereof. The thermal element may be used in an ablation procedure or other procedure to heat a tissue adjacent a vessel. In some instances, the thermal element may be positioned in a first vessel and may operate to heat tissue adjacent a second vessel or adjacent an ostium between the first vessel and the second vessel. Further, the catheter may include an expandable portion on which the thermal element may be connected or positioned. The expandable portion(s) may comprise a basket or cage, a balloon, a memory shape and formable portion, and/or other mechanical expanders.

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Номер записи: 40

16-05-2013 дата публикации

Methods and devices for manipulation of target cells using a combined application of acoustical and optical radiations

Номер: US20130122564A1

Автор: Boris Krasovitski, Eitan Kimmel, Shy Shoham

Принадлежит: Technion Research and Development Foundation Ltd

A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern.

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Номер записи: 41

16-05-2013 дата публикации

INTEGRATED ULTRASOUND ABLATION AND IMAGING DEVICE AND RELATED METHODS

Номер: US20130123625A1

Автор: Edmunds Kevin D., HASTINGS ROGER N., Pikus Michael J., RICHARDSON LEONARD B., Smith Scott R., Teo Tat-Jin

Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

Intravascular nerve modulation systems and methods for making and using the same are disclosed. An example system may include an elongate shaft having a proximal end region and a distal end region and a central longitudinal axis. An ablation transducer may be disposed at the distal end region. The system may also include a rotational drive configured to rotate the ablation transducer about the central longitudinal axis. A control and power system may be operably connected to the ablation transducer and the rotational drive. In some instances, the ablation transducer may be a combined ablation and imaging transducer. 1. An intravascular nerve modulation system , comprising:an elongate shaft having a proximal end region and a distal end region and a central longitudinal axis;an ablation transducer disposed at the distal end region;a rotational drive configured to rotate the ablation transducer about the central longitudinal axis; anda control and power system operably connected to the ablation transducer and the rotational drive.2. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer is a combined ablation and imaging transducer.3. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer comprises a single planar ablation transducer.4. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer comprises a plurality of ablation transducers claim 1 , the plurality of ablation transducers disposed in a single plane.5. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer comprises a first ablation transducer and a second ablation transducer claim 1 , the second ablation transducer defining a first cavity in which the first ablation transducer is disposed.6. The intravascular nerve modulation system of claim 5 , wherein the ablation transducer further comprises a third ablation transducer claim 5 , the third ablation transducer defining a second ...

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Номер записи: 42

16-05-2013 дата публикации

Dissection handpiece and method for reducing the appearance of cellulite

Номер: US20130123771A1

Автор: Adnan I. Merchant, Ben F. Brian, III, James E. Chomas, Robert L. Clark, Iii

Принадлежит: Cabochon Aesthetics Inc

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

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Номер записи: 43

13-06-2013 дата публикации

Catheter balloon methods and apparatus employing sensing elements

Номер: US20130150693A1

Автор: Bassel de Graff, Cliff Liu, Kevin Dowling, Lauren Klinker, Robert D'Angelo, Roozbeh Ghaffari, Stephen P. Lee, Yung-Yu Hsu

Принадлежит: Individual

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

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Номер записи: 44

20-06-2013 дата публикации

Self operated esthetic device with a substrate

Номер: US20130158634A1

Автор: Oded Ron Edoute, Orit Ron Edoute

Принадлежит: VENUS CONCEPT LTD

The present invention provides a self-operated device for treating a skin of a patient, comprising: a. a substrate having a first side and a second side; b. a plurality of RF electrodes arranged in said substrate, said RF electrodes are configured to emit RF radiation from said first side to the surface of said skin; c. at least one RF generator configured to generate pulses of current to said RF electrodes; and, d. a control unit connected to said at least one RF generator, said control unit is adapted to control the operation of said RF electrodes; wherein said control unit is adapted to control the operation of said RF electrodes according to a predetermined treatment protocol, such that the same activates or deactivates at least one of said RF electrodes at any predetermined time interval according to a predetermined pattern so as to achieve a particular therapeutic result.

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Номер записи: 45

27-06-2013 дата публикации

Ultrasonic irradiation device

Номер: US20130165823A1

Автор: Hiroshi Tsuruta, Miyuki Murakami, Yoshiharu Ishibashi

Принадлежит: Olympus Corp

An ultrasonic irradiation device includes a sound source, a holding member, a first support member and a second support member. The sound source is configured to be placed in a space at least a part of which is covered with a wall surface and emit an ultrasonic wave toward a target area. The holding member is configured to hold the sound source. The first support member is configured to push a first area of the wall surface so that a distance between the sound source and the target area is kept at a predetermined value, the first supporting member being disposed on the holding member. The second support member is configured to push a second area of the wall surface including an area other than the first area so that the sound source is fixed to the wall surface together with the first support member.

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Номер записи: 46

25-07-2013 дата публикации

Dissection handpiece and method for reducing the appearance of cellulite

Номер: US20130190739A1

Автор: Adnan I. Merchant, Ben F. Brian, III, James E. Chomas, Robert L. Clark, Iii

Принадлежит: Cabochon Aesthetics Inc

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

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Номер записи: 47

01-08-2013 дата публикации

System and method for determining the optimum size of an ultrasonic wave generation device

Номер: US20130197400A1

Автор: Fabrizio Romano, Florent Aptel, Laurent Farcy

Принадлежит: EYE TECH CARE

The present invention relates to a method for determining a probe model for treating an eye pathology, from among a plurality of different probe models, each probe including a cone-shaped ring including a proximal end ( 11 ) intended to be in contact with one eye ( 4 ) of a patient and a distal end ( 12 ) intended to receive means for generating ultrasonic waves ( 2 ), the method comprising a step for receiving at least one measurement of a biometric parameter of the eye, and a step for determining the optimum probe model according to each biometric parameter.

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Номер записи: 48

01-08-2013 дата публикации

OPTIMIZATION OF ULTRASOUND WAVEFORM CHARACTERISTICS FOR TRANSCRANIAL ULTRASOUND NEUROMODULATION

Номер: US20130197401A1

Автор: Sato Tomo, Tyler William J., Wetmore Daniel Z.

Принадлежит:

The present invention relates to methods and systems for achieving effective neuromodulation by transcranial ultrasound (bioTU). Embodiments of the invention include methods and systems for selecting, generating, and delivering transcranial ultrasound to the brain of a living subject. Methods and systems are described for determining the effect of bioTU on brain function. Certain embodiments of the present invention include methods and systems for measuring at least one quantifiable metric of brain activity, cognitive function, or physiology in order to optimize the ultrasound waveforms delivered. In an embodiment, the invention uses a closed-loop design to iteratively improve the effectiveness of bioTU waveforms delivered. 1. A system for delivering and assessing transcranial ultrasound neuromodulation protocols during a transcranial ultrasound neuromodulation session , said system comprising:at least one control component configured to select at least one ultrasound waveform to deliver to a subject;at least one stimulation component configured to deliver said at least one ultrasound waveform to the brain of the subject; andat least one transcranial ultrasound neuromodulation assessment component configured to measure one or more changes in brain or body of the subject induced by transcranial ultrasound neuromodulation,wherein said at least one control component, at least one stimulation component, and at least one transcranial ultrasound neuromodulation assessment component are configured to communicate and operate in conjunction with one another in order to:select a plurality of transcranial ultrasound neuromodulation waveforms, wherein each one of said plurality of transcranial ultrasound neuromodulation waveforms is (i) selectable by said at least one control component, (ii) configured to be delivered to the brain of said subject by said at least one stimulation component, and (iii) capable of generating a response measured for efficacy by at least one of said ...

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Номер записи: 49

08-08-2013 дата публикации

Apparatus and Methods For Treating Pulmonary Hypertension

Номер: US20130204068A1

Автор: COE JONATHAN A., Gnanashanmugam Swaminadhan, Koehler Jeremy Christopher, Suh Insoo

Принадлежит: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension. 1. A method of decreasing activity of at least one sympathetic nerve , nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension , the method comprising:advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient; andusing the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.2. A method as in claim 1 , wherein advancing the treatment device comprises advancing an energy transmission device that emits energy selected from the group consisting of monopolar radiofrequency claim 1 , bipolar radiofrequency claim 1 , other forms of radiofrequency claim 1 , high intensity focused ultrasound claim 1 , low frequency ultrasound claim 1 , other forms of ultrasound claim 1 , microwave claim 1 , light claim 1 , heat claim 1 , cold radiation claim 1 , phototherapy claim 1 , magnetic claim 1 , electrical claim 1 , electromagnetic claim 1 , cryotherapy claim 1 , plasma claim 1 , mechanical claim 1 , chemical claim 1 , kinetic claim 1 , potential claim 1 , nuclear claim 1 , elastic and hydrodynamic energy claim 1 , and wherein using the treatment device comprises emitting ...

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Номер записи: 50

08-08-2013 дата публикации

Ultrasound transceiver and cooling thereof

Номер: US20130204167A1

Автор: Ariel Sverdlik, Or Shabtay

Принадлежит: Cardiosonic Ltd

An ultrasonic transceiver device for producing ultrasonic beams comprises a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused, or alternatively a focused, power beam for thermal tissue damage, the power beam being produced by vibration over the body of the transceiver and emanating from the extent of the surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.

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Номер записи: 51

15-08-2013 дата публикации

Methods for face and neck lifts

Номер: US20130211258A1

Автор: Inder Raj S. Makin, Michael H. Slayton, Peter G. Barthe

Принадлежит: Guided Therapy Systems LLC

Methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Methods of lifting sagging tissue on a face and/or neck are described.

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Номер записи: 52

10-10-2013 дата публикации

Methods and systems for ablating tissue

Номер: US20130267875A1

Автор: David A. Gallup, Hira V. Thapliyal, James W. Arenson, Robert Brommer

Принадлежит: VytronUS Inc

A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

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Номер записи: 53

24-10-2013 дата публикации

Skin treatment devices and methods

Номер: US20130282085A1

Автор: Daniel Lischinsky, Yoram Harth

Принадлежит: EndyMed Medical Ltd

A skin treatment device for home use is provided herein. The device has enhanced safety features and improved operation efficiency. RF energy is delivered under strict control to a relatively small and well localized volume of the skin, avoiding excessive heating of the skin surface. Surface heating is monitored both by direct temperature measurement and by movement monitoring of the device to ensure proper use and prevent skin overheating and the pain associated therewith.

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Номер записи: 54

31-10-2013 дата публикации

Medical imaging contrast devices, methods, and systems

Номер: US20130289398A1

Автор: Elisa E. Konofagou, Fotios Vlachos, Jameel A. Feshitan, Mark A. Borden

Принадлежит: Columbia University of New York

Systems, methods, and devices for generating and using size-selected lanthanide-coated microbubbles for controlling an imaging signal via microbubble fragmentation and for magnetic resonance imaging guided focused ultrasound therapy.

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Номер записи: 55

07-11-2013 дата публикации

Delivery devices with coolable energy emitting assemblies

Номер: US20130296647A1

Автор: Martin L. Mayse, Steven C. Dimmer

Принадлежит: Holaira Inc

Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input.

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Номер записи: 56

14-11-2013 дата публикации

System and Method for Non-invasive Cosmetic Treatment

Номер: US20130303904A1

Автор: Michael Slayton, Peter Barthe

Принадлежит: Guided Therapy Systems LLC

Embodiments of a dermatological cosmetic treatment and imaging system and method can include use of a hand wand and a removable transducer module having an ultrasound transducer. The system can include a control module that is coupled to the hand wand and has a graphical user interface for controlling the removable transducer module, and an interface coupling the hand wand to the control module. In some embodiments, the cosmetic treatment system may be used in cosmetic procedures on at least a portion of a face, head, neck, body, and/or other part of a patient for a face lift, a brow lift, a chin lift, an eye treatment, a wrinkle reduction, a scar reduction, a burn treatment, a tattoo removal, a skin tightening, a vein reduction, a treatment on a sweat gland, a treatment of hyperhidrosis, a sun spot removal, a fat treatment, a vaginal rejuvenation, and/or an acne treatment.

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Номер записи: 57

12-12-2013 дата публикации

NEURONAVIGATION-GUIDED FOCUSED ULTRASOUND SYSTEM AND METHOD THEREOF

Номер: US20130331685A1

Автор: LIU Hao-Li, LU Yu-Jen, TSAI Hong-Chieh, WEI Kuo-Chen

Принадлежит: CHANG GUNG UNIVERSITY

The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point. 1. A neuronavigation-guided focused ultrasound system , which guides a focused ultrasound energy to a target point , comprisinga focused ultrasound device generating a focus point and delivering said energy to said target point;a neuronavigation system electrically connecting with said focused ultrasound device and including a calibration unit, wherein said calibration unit establishes a positional relationship between said focus point and an image of a interested region of an individual, performs a calibration process on coordinates, and enables said neuronavigation system to recognize said focus point and define said target point; anda fixture fixing said interested region of said individual.2. The neuronavigation-guided focused ultrasound system according to claim 1 , wherein said focused ultrasound device further comprisesa signal generator generating an ultrasonic signal;a signal amplifier electrically connecting with said signal generator and amplifying said ultrasonic signal into said focused ultrasound; andan ultrasonic transducer electrically connecting with said signal amplifier, delivering said focused ultrasound to said target point, wherein a central frequency of said focused ultrasound resonates with said ultrasonic ...

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Номер записи: 58

12-12-2013 дата публикации

Bifurcated catheter

Номер: US20130331921A1

Автор: Gary Roubin

Принадлежит: Individual

Systems and methods are disclosed for a bifurcated catheter, and more particularly, to denervation of arterial nerves using a bifurcated catheter. In embodiments, the catheter comprises, for example, a catheter shaft bifurcated into a first catheter energy member and a second catheter energy member, wherein the first catheter energy member comprises a first transducer and the second catheter energy member comprises a second transducer, and wherein the first and second transducers are configured to cause denervation of an arterial nerve of the patient.

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Номер записи: 59

19-12-2013 дата публикации

Calculating the speed of ultrasound in at least two tissue types

Номер: US20130338485A1

Автор: Charles Mougenot, Gösta Jakob Ehnholm, Iipo Asko Julius Koskela, Max Oskar KÖHLER

Принадлежит: Koninklijke Philips NV

A medical apparatus ( 400 ) comprising an ultrasound transmitter ( 444, 602 ) and receiver ( 446, 604 ) system ( 600 ) for acquiring ultrasound data ( 476 ) descriptive of the speed of ultrasound ( 304, 306 ) along at least two paths ( 606, 1114 ). The medical apparatus further comprises a medical imaging system ( 402 ) for acquiring medical image data ( 468 ) and a memory ( 464 ) containing instructions ( 490, 492, 494, 496, 498, 500, 502, 504 ) that causes the processor to acquire ( 100, 200 ) the medical image data. The instructions further cause the processor to acquire ( 102, 202 ) the ultrasound data. The instructions further cause the processor to segment ( 104, 204 ) the medical image data into at least two tissue types ( 434, 436, 610, 612, 708, 710 ). The instructions further causes the processor to determine ( 106, 206 ) at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate ( 108, 208 ) the speed of ultrasound in the at least two tissue types.

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Номер записи: 60

26-12-2013 дата публикации

Magnetic resonance measurement of ultrasound properties

Номер: US20130345547A1

Автор: Erkki Tapani Vahala

Принадлежит: Koninklijke Philips NV

An apparatus ( 500, 600 ) comprising an ultrasound transducer element ( 300 ) for generating an ultrasonic beam ( 302 ) through a target zone ( 308, 538 ). The ultrasonic beam has an ultrasound frequency. The apparatus comprises a magnetic resonance system ( 502 ) with a resonant frequency modulator ( 542, 544, 516 ) for modulating a magnetic resonance frequency relative to a magnetic resonance of molecules in the target zone at the ultrasound frequency. Instructions cause a processor to repeatedly generate ( 100, 204 ) first gradient commands ( 562 ) which cause a magnetic field gradient coil to generate a first gradient magnetic field ( 710, 810 ) through the target zone. The gradient magnetic field has field lines directed in a first direction ( 304 ). The processor repeatedly modulates ( 102, 206 ) the magnetic resonance frequency at the ultrasound frequency, generates ( 104, 208 ) ultrasound commands ( 566 ), acquires ( 106, 210 ) magnetic resonance data from the target zone, and generates ( 108, 212 ) second gradient commands ( 564 ).

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Номер записи: 61

23-01-2014 дата публикации

Transoesophageal device using high intensity focused ultrasounds for cardiac thermal ablation

Номер: US20140024923A1

Автор: Cyril Lafon, Elodie Constanciel, Jean-Yves Chapelon

Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM

The present invention relates to a probe that comprises a piezoelectric therapy transducer having an acoustic axis BB′, and an imaging transducer having an imaging plane, in which the therapy transducer and imaging transducer are mounted in a head which is itself connected to a guide. More particularly, the therapy transducer is in a form of a truncated cup and has a spherical concave front face for emitting ultrasonic waves focused on a focal point, a rear surface and the therapy transducer is truncated alone two parallel lanes such that a length d 1 , a width t and a longitudinal direction are provided; the therapy transducer is a 1D annular phased array transducer and the imaging transducer is a multiplane transducer having a rotation axis corresponding to the acoustic axis of the therapy transducer whereby the focal point of the therapy transducer is comprised in the imaging plane of the imaging transducer, said imaging transducer being fixed to the therapy transducer

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Номер записи: 62

06-02-2014 дата публикации

Acoustic palpation using non-invasive ultrasound techniques for identification of target sites and assessment of chronic pain disorders

Номер: US20140039279A1

Автор: Abbi M McClintic, Jeffrey G. Jarvik, Michael Gofeld, Michel Kliot, Pierre Mourad, Robert C.A. Frederickson, Trevor C. Dickey

Принадлежит: PhysioSonics Inc, UNIVERSITY OF WASHINGTON

Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.

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Номер записи: 63

06-02-2014 дата публикации

Energetic modulation of nerves

Номер: US20140039479A1

Автор: Michael Gertner

Принадлежит: Kona Medical, Inc.

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

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Номер записи: 64

06-02-2014 дата публикации

Methods of securing a fastener

Номер: US20140039495A1

Автор: Justin E. Beyers, Matthew J. Cremens, Peter M. Bonutti

Принадлежит: P Tech LLC

Embodiments may include an attachable fastener, which may include a bondable material that may be secured to the end of an end effector. Vibration may be tuned to occur at a distal end of the fastener. Accordingly, the fastener may be used to generate heat at a distal point of contact. If the contact surface contains bondable material, that material may be softened. If the fastener includes bondable material at the point of contact, that material may also be softened by heat produced by vibration at the contact area. A hard implant or another polymeric material may function as the anvil.

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Номер записи: 65

27-02-2014 дата публикации

Tissue treatment and monitoring by application of energy

Номер: US20140058294A1

Автор: Gideon Meiry, Leonid KUSHKULEY, Liat Tsoref, Michael Kardosh, Yaron Assaf, Yossi Gross

Принадлежит: Rainbow Medical Ltd

Apparatus is provided, which includes at least one ultrasound transducer. The ultrasound transducer is configured to be positioned within a lumen of a subject and to ablate tissue surrounding a wall of the lumen without ablating the wall of the lumen, by focusing ultrasound energy on a focal zone that is outside of the wall of the lumen. A transluminal delivery tool is configured to position the ultrasound transducer in the lumen, and a control unit is configured to drive the ultrasound transducer. Other embodiments are also described.

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Номер записи: 66

27-02-2014 дата публикации

Combination ultrasound-phototherapy transducer

Номер: US20140058296A1

Автор: Brady Aller, Mark E. Schafer

Принадлежит: Sonic Technologies Inc

A soundhead of a treatment device is provided that enables a volume of tissue located beneath the soundhead to simultaneously receive ultrasound and light stimulation. According to one embodiment, the soundhead includes an ultrasound transducer, a light source, and a faceplate extending across a face of the transducer for providing a tissue contacting and ultrasound energy coupling surface of the soundhead. The faceplate is transparent or translucent to the light generated by the light source. Alternate embodiments including externally mounted light sources are also disclosed.

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Номер записи: 67

20-03-2014 дата публикации

Methods and apparatus for renal neuromodulation

Номер: US20140081259A1

Автор: Denise Zarins, Douglas Sutton, Erik Thai, Hanson Gifford, III, Howard R. Levin, Mark E. Deem, Mark Gelfand

Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

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Номер записи: 68

03-04-2014 дата публикации

System and method for tattoo removal

Номер: US20140094718A1

Автор: Stephen Feldman

Принадлежит: Individual

A combination device for applying a treatment of light and ultrasound on a tattooed area of a patient desiring tattoo removal. The device includes an ultrasound and a LED light source. The ultrasound source produces high-frequency ultrasound waves. These waves are applied directly to the tattooed area for a first specified period of time resulting in release of tattoo ink from tattooed cells. The LED source produces a continuous high-intensity light that is applied directly over the entire tattooed area for a second specified period of time resulting in degradation of the tattoo ink.

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Номер записи: 69

03-04-2014 дата публикации

Ultrasound neuromodulation treatment of schizophrenia

Номер: US20140094719A1

Автор: David J Mishelevich

Принадлежит: Individual

Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat schizophrenia. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.

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Номер записи: 70

04-01-2018 дата публикации

PRESERVATION AND TRANSPORT OF AN EX VIVO BIOLOGICAL SAMPLE COMPRISING ULTRASOUND APPLICATION

Номер: US20180000068A1

Автор: Peralta Carmen

Принадлежит:

The present invention relates to a device for transport and preservation of an ex vivo biological sample and corresponding method. The device () comprises a chamber () for containing the biological sample (), delimitated by walls () made of a thermal insulating material. The device, furthermore, incorporates cooling means () that keep the temperature inside the chamber () below the temperature outside the device (). Finally, an ultrasound system suitable for generating and applying ultrasound on the biological sample () is provided. The invention also proposes a method for transport and preservation which combines applying cooling and ultrasound to reduce cell damage in the biological sample. 111002100462114100100. A device () for transport and preservation of an ex vivo biological sample () for subsequent transplant in a living human being or animal , comprising a chamber () for containing said biological sample () , delimitated by walls () made of a thermal insulating material and cooling means () for keeping the temperature inside said chamber () below the temperature outside said device () , characterized in that it further comprises an auxiliary container () for containing a preservation solution , without external oxygen delivery and for containing said biological sample () immersed in said preservation solution and at least an ultrasound system suitable for generating and applying ultrasound on said biological sample ().2114. The device () according to claim 1 , characterized in that said auxiliary container () is closable.31. The device () according to claim 1 , characterized in that said ultrasound system is suitable for emitting said ultrasound at a frequency comprised between 25 kHz and 1 MHz and a sound intensity comprised between 0.01 and 2 W/cm.41. The device () according to claim 3 , characterized in that said sound intensity is comprised between 0.02 and 1 W/cm.5162. The device () according to claim 1 , characterized in that said cooling means () are ...

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Номер записи: 71

07-01-2016 дата публикации

INTERNAL ULTRASOUND ASSEMBLY WITH PORT FOR FLUID INJECTION

Номер: US20160000405A1

Автор: Fearnot Neal E., Havel William J., McKinnis Peter S., Robbins Sarah, Zhou Yun

Принадлежит:

There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms. 1. An apparatus for ultrasound procedures , comprising:a transducer for emitting and/or receiving ultrasound signals, the transducer being within a chamber, the chamber defined at least partially by a wall forming an acoustic window for transmission of ultrasound signals;an injection port communicating with the chamber adapted for passing coupling media through and into the chamber, andan exhaust port communicating with the chamber through which gas within the chamber can be exhausted from the chamber when coupling media is inserted into the chamber.2. The apparatus of claim 1 , wherein the injection port comprises a flexible insert fixed with respect to the wall claim 1 , the insert permitting insertion of a needle through it and thereafter providing a leak-tight seal when a needle is removed from it.3. The apparatus of claim 1 , wherein the insert is placed at a forward-most tip of the chamber.4. The apparatus of claim 1 , wherein the chamber is attached to or part of an elongated tubular housing having an internal surface and an external surface claim 1 , and wherein the injection port comprises a lumen opening into the chamber and extending through at least part of the housing between the internal surface and the external surface.5. The apparatus of claim 4 , wherein at least part of the lumen is within a tube ...

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Номер записи: 72

07-01-2016 дата публикации

Integrated System for Ultrasound Imaging and Therapy using Per-Pixel Switches

Номер: US20160000412A1

Автор: Amin Nikoozadeh, Anshuman BHUYAN, Butrus T. Khuri-Yakub, Jung Woo Choe

Принадлежит: Leland Stanford Junior University

Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.

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Номер записи: 73

03-01-2019 дата публикации

PHASED ARRAY TRANSDUCER WITH COUPLING LAYER FOR SUPPRESSION OF GRATING LOBES

Номер: US20190000416A1

Автор: Hynynen Kullervo Henrik

Принадлежит:

An ultrasound phased array transducer is disclosed that achieves suppression of grating lobes through the incorporation of a coupling layer, where the coupling layer is positioned adjacent to the phased array transducer such that an ultrasound beam propagates through the coupling layer prior to encountering a propagation medium. The phased-array elements may be provided such that one or both of the array pitch and a lateral extent of each ultrasound transducer element is larger than half of the ultrasound wavelength in the propagation medium. Grating lobes within the coupling layer and the propagation medium may be reduced or suppressed by selecting a coupling material having a speed of sound that exceeds that of the propagation medium. The coupling layer may have a thickness sufficient for the generation of a wavefront, and the coupling layer may be formed from a viscous or viscoelastic material. 1. A phased array ultrasound transducer comprising:an array of ultrasound transducer elements configured for emitting a phased-array ultrasound beam therefrom, wherein each ultrasound transducer element has an associated ultrasound emission wavelength in soft tissue, wherein a lateral extent of each transducer element is larger than half of the ultrasound wavelength in soft tissue; anda coupling layer contacting said array of ultrasound transducer elements, said coupling layer having a speed of sound greater than the speed of sound of soft tissue and a thickness sufficient for the generation of a wavefront therein, thereby reducing or suppressing the generation of grating lobes.2. The phased array ultrasound transducer according to wherein said coupling layer has a speed of sound that is sufficiently high to suppress the generation of grating lobes.3. The phased array ultrasound transducer according to wherein a ratio of the lateral extent of each transducer element to half of the ultrasound wavelength in soft tissue is less than the ratio of the speed of sound of the ...

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Номер записи: 74

03-01-2019 дата публикации

ELASTICITY IMAGING IN HIGH INTENSITY FOCUSED ULTRASOUND

Номер: US20190000422A1

Автор: Chen Kailiang, Ralston Tyler S., Satir Sarp, West Lawrence C., Zahorian Jaime Scott

Принадлежит:

Ultrasound devices configured to perform high-intensity focused ultrasound (HIFU) are described. An ultrasound device may include HIFU units configured to emit high acoustic intensities and elasticity detectors configured to determine characteristics of the target area of a human body based on the elasticity of the target area. The elasticity detectors may determine, e.g., whether the target area is healthy, and if not, the type cell in need of treatment (e.g., the type of cancer cell present in the target area). In one example, the elasticity detectors may be configured to determine the stiffness of the target area, which may provide an indication as to the type of cell present in the area, by estimating the velocity of a shear wave propagating away from the target area. The shear wave may arise in response to the application of an ultrasound wave to the target area. 1. An apparatus comprising:one or more high intensity focused ultrasound (HIFU) units configured to generate HIFU waves and one or more elasticity detectors configured to sense a characteristic of a shear wave, the one or more HIFU units and the one or more elasticity detectors being disposed on a common ultrasound device.2. The apparatus of claim 1 , wherein the ultrasound device comprises a substrate on which ultrasonic transducers are integrated.3. The apparatus of claim 1 , wherein the ultrasound device comprises a handheld probe.4. The apparatus of claim 1 , wherein at least one of the one or more HIFU units comprises a capacitive micromachined ultrasound transducer (CMUT).5. The apparatus of claim 1 , wherein at least one of the one or more HIFU units is configured to emit an acoustic intensity that is between 500 W/cmand 20 KW/cm.6. The apparatus of claim 1 , wherein the one or more HIFU units are disposed on a first substrate claim 1 , the first substrate being bonded to a second substrate comprising electronic circuitry electrically coupled to the one or more HIFU units.7. The apparatus of ...

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Номер записи: 75

03-01-2019 дата публикации

METHOD FOR STIMULATING, AND APPARATUSES PERFORMING THE SAME

Номер: US20190000426A1

Автор: KIM HyungGuk, KIM SEONGYEON, Lee HyunJoo

Принадлежит: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Disclosed is a method and apparatus for more locally stimulating a desired stimulation region in a predetermined part of an object, the apparatus including a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object, a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object, and a controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle. 1. A stimulating apparatus , comprising:a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object;a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object; anda controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle.2. The stimulating apparatus of claim 1 , wherein the controller is configured to control an arrangement position of at least one of the first ultrasonic wave generator and the second ultrasonic wave generator such that focus points of the first ultrasonic wave generator and the second ultrasonic wave generator match.3. The stimulating apparatus of claim 2 , wherein the controller is configured to control an output intensity of at least one of the first ultrasonic wave generator and the second ultrasonic wave generator such that intensities of the first ultrasonic beam and the second ultrasonic ...

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Номер записи: 76

03-01-2019 дата публикации

Setting of sonothromobolysis ultrasound output power

Номер: US20190000493A1

Автор: Jeffry Earl Powers, Ralf Seip, Sarah Rhoades Baxter, Sonia Souza, Terrence James Sweeney, William Tao Shi

Принадлежит: Koninklijke Philips NV

An apparatus for patient-specific adjusting of ultrasound output pressure includes a controller (118) configured for adjusting, based on an estimate of thickness of a temporal bone (140) in a head of a medical treatment recipient, a pressure setting. It may also be based on treatment depth (134). Ultrasound at the adjusted pressure setting is applied. A user interface may be provided for user entry of the estimate, the user interface being further configured for user indication of the treatment depth. Both the entered estimate and the indicated treatment depth may be used in calculating ultrasound attenuation (148). The user indication can be interactive by virtue of designating, on a display, a location of a treatment target. The calculated attenuation may be a value, in decibels, that is in a range from 0.9×(2.70×0.1+16.60×T+0.87×(D−T−0.1)+3.02) to 1.1×(2.70×0.1+16.60×T+0.87×(D−T−0.1)+3.02), where T is the estimate in centimeters and D is the treatment depth in centimeters.

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Номер записи: 77

03-01-2019 дата публикации

System and Method for Ultra-High Frequency Ultrasound Treatment

Номер: US20190000498A1

Автор: Barthe Peter G., Slayton Michael H.

Принадлежит:

A noninvasive ultra-high frequency ultrasound treatment method and system are provided. An exemplary method system comprise a high-frequency ultrasound transducer system configured for providing ultrasound treatment to a patient such that the superficial and/or subcutaneous regions of the patient can be treated. An exemplary high-frequency ultrasound transducer system comprises a control system and a transducer configured to provide treatment to the superficial and/or subcutaneous regions of interest. The high-frequency ultrasound transducer may be configured to operate at higher frequencies and controlled power levels to provide treatment to the superficial and/or subcutaneous regions of interest. For example, higher frequencies within the range from approximately 20 MHz to 500 MHz or more may be utilized. 1. A method for providing treatment to a patient , the method comprising:coupling an ultrasound transducer to a skin surface of a patient;emitting energy from the ultrasound transducer into a superficial region of interest below the skin surface of the patient, the superficial region of interest consisting of a subcutaneous layer of skin;ablating tissue in a portion of the region of interest;creating a lesion in the tissue at a depth in a range of 0.1 μm to 100 μm below the skin surface; andsparing tissue at the depth of greater than 100 μm below the skin surface from damage from the ablating tissue.2. The method according to claim 1 , wherein the subcutaneous layer of skin comprises an epidermis layer.3. The method according to claim 1 , further comprisingimaging at least a portion of the superficial region of interest; anddisplaying the at least a portion of the superficial region of interest.4. The method according to claim 1 , wherein the emitting energy from the ultrasound transducer is in a power range of 80 W/cmto 100 W/cm.5. The method according to claim 1 , wherein the emitting energy from the ultrasound transducer is in a power range of 15 W/cmto 500 W/ ...

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Номер записи: 78

07-01-2021 дата публикации

SIMULATION-BASED FOCUSED-ULTRASOUND TREATMENT PLANNING

Номер: US20210000541A1

Автор: Assif Benny, Halevy Gilad, Hertzberg Yoni, Levy Yoav

Принадлежит:

A focused-ultrasound or other procedure for treating a target within a tissue region can be planned iteratively by creating a treatment plan specifying a treatment location pattern and stimuli applied thereto, simulating the treatment, computationally predicting an effect of the simulated treatment, comparing the predicted effect against one or more treatment constraints (such as efficacy and/or safety thresholds), and, if a constraint is violated, repeating the simulation for an adjusted treatment plan. 121-. (canceled)22. A system for performing targeted drug delivery via disruption of a barrier region , the system comprising:a treatment system comprising an ultrasound transducer;a processor; and (a) simulate treatment in accordance with the stored treatment plan at least in part by computationally traversing the focus pattern and computationally applying the temporally variable sonications thereto;', '(b) computationally predict a degree of barrier region disruption resulting from the simulated treatment based on the data descriptive of the model of the barrier region and a physical model modelling propagation of the degree of barrier region disruption;', '(c) compare the predicted degree of barrier disruption against the at least one stored treatment constraint;', '(d) if the predicted degree of barrier disruption violates the at least one treatment constraint, (i) alter the treatment plan and (ii) repeat steps (a) through (d) for the altered treatment plan; and', '(e) operating the treatment system to conduct the temporally variable sonications in accordance with the altered treatment plan., 'memory storing (i) data descriptive of a model of the barrier region and at least one treatment constraint as well as (ii) a treatment plan specifying a focus pattern corresponding to at least a subregion of the barrier region and temporally variable sonications to be applied sequentially along the focus pattern, wherein the sonications are characterized by one or more ...

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Номер записи: 79

06-01-2022 дата публикации

DEVICE FOR TREATMENT OF A TISSUE AND METHOD OF PREPARATION OF AN IMAGE OF AN IMAGE-GUIDED DEVICE FOR TREATMENT OF A TISSUE

Номер: US20220001213A1

Автор: Lacoste Francois, PECHOUX Thierry

Принадлежит:

A device for treatment of a tissue () of a living being, including a transducer () for emitting a beam of ultrasound waves mounted on a movable treatment head (), an ultrasonic imaging device (), optionally an inflatable balloon () surrounding the treatment head () and containing a coupling fluid, and a control unit for controlling movement of the treatment head () and operation of the transducer () and the imaging device (). In order to avoid displacement of tissues () during displacement of the treatment head () and increase imaging quality, the treatment head () is adjustable to at least two of a treatment position (T), a monitoring position (M) and a travel position (S). 117-. (canceled)18. A device for treatment of a tissue of a living being , the device comprising:a transducer, for emitting a beam of ultrasound waves for irradiating the tissue, mounted on a movable treatment head, and the beam being focused on or focusable onto a focal point;an ultrasonic imaging device mounted on the treatment head having an imaging plane intersecting the focal point;an inflatable balloon at least partially surrounding the treatment head, containing a coupling fluid and defining a contact surface of the treatment head; anda control unit for controlling movement of the treatment head and operation of the transducer and the imaging device;wherein the treatment head is adjustable to a treatment position and a monitoring position,in the monitoring position, a distance between the transducer and the tissue is smaller than in the treatment position, andthe control unit is adapted to:trigger the transducer to emit at least one beam of ultrasound waves when the treatment head is in the treatment position, andperform imaging of an area, surrounding the tissue, at least when the treatment head is in the monitoring position.19. The device according to claim 18 , wherein the control unit is adapted to move the treatment head claim 18 , after emission of an ultrasound pulse from the ...

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Номер записи: 80

03-01-2019 дата публикации

METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Номер: US20190000545A1

Автор: Deem Mark, Gelfand Mark, GIFFORD, III Hanson, Levin Howard R., Wu Andrew, Zarins Denise

Принадлежит: Medtronic Ardian Luxembourg S.a.r.l.

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy. 117-. (canceled)18. A method for treating a hypertensive human patient , the method comprising:intravascularly positioning a thermal apparatus carried by a renal denervation catheter at least proximate to renal nerves of the patient;delivering thermal energy via the thermal apparatus to modulate a function of the renal nerves via thermal effects; andintravascularly removing the renal denervation catheter from the patient after delivering the thermal energy to conclude the procedure.19. The method of wherein intravascularly positioning a thermal apparatus comprises intravascularly positioning the thermal apparatus within a renal artery of the patient proximate to the renal nerves.20. The method of wherein the renal denervation catheter comprises an expandable element at a distal region of the catheter claim 18 , and wherein the thermal apparatus is carried by the expandable element claim 18 , and wherein the method further comprises:transforming the expandable element from a low-profile delivery configuration to an expanded treatment configuration within a renal artery of the patient after intravascularly positioning the thermal apparatus at least proximate to renal nerves and before delivering ...

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Номер записи: 81

02-01-2020 дата публикации

Vaginal remodeling device and methods

Номер: US20200000517A1

Автор: Chun-Chih Cheng, Ian F. Smith, Jerome Jackson, Jonathan B. Parmer, Patrick Karl Howe, Sean Yasuo Sullivan, Sheree Leigh LUCAS, Stanley Levy, Steven Marc Lopez

Принадлежит: Viveve Inc

This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

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Номер записи: 82

07-01-2016 дата публикации

Shock Wave Applicator with Movable Electrode

Номер: US20160000645A1

Автор: Christopher M. Cashman, Iulian Cioanta

Принадлежит: Sanuwave Inc

A shock wave applicator includes a reflector and a movable shockwave-generating electrode disposed in the reflector at a first focal point. The reflector is at least a portion of an ellipsoidal shape having a long and small axis with the first focal point and a second focal point on the long axis, and the reflector terminates at an edge defining a membrane-covered aperture on a plane intersecting the small axis and coincident with the second focal point.

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Номер записи: 83

07-01-2016 дата публикации

METHOD AND APPARATUS FOR PREVENTING LOCALIZED STASIS OF CEREBROSPINAL FLUID

Номер: US20160001095A9

Автор: Lee Susan J.

Принадлежит:

A system and method for treating, inhibiting or ameliorating Alzheimer's disease in a patient, comprising one or more transducers operatively connected to a power source for radiating vibrational or acoustical energy to the maxilla of the patient, wherein the energy is sufficient to radiate through the paranasal sinuses of the patient to the base of the patient's skull to assist in cerebrospinal fluid clearance and inhibit localized stasis of cerebrospinal fluid in the brain. 1. A method for treating , inhibiting or ameliorating localized stasis of cerebrospinal fluid in the brain of a patient , comprising administering vibrational or acoustical energy to the maxilla of the patient , wherein the energy is sufficient to radiate through the paranasal sinuses of the patient to the base of the patient's skull to assist in cerebrospinal fluid clearance and inhibit localized stasis of cerebrospinal fluid in the brain.2. The method according to claim 1 , wherein the vibrational or acoustical energy is administered to the maxilla via one or more transducers operatively connected to a power source.3. The method according to claim 2 , wherein the one or more transducers radiate energy to one or more upper teeth of the patient.4. The method according to claim 2 , further comprising inserting a mouthpiece over the patient's upper teeth or upper jaw claim 2 , wherein the one or more transducers are disposed on the mouthpiece and direct vibrational or acoustical energy to the patient's upper teeth or upper jaw.5. The method according to claim 2 , wherein the one or more transducers are ultrasonic transducers.6. The method according to claim 2 , wherein the one or more transducers are sonic transducers.7. The method according to claim 2 , wherein the one or more transducers are supersonic transducers.8. The method according to claim 2 , wherein the transducer is releasably connected to an implant disposed in the maxilla of the patient.9. The method according to claim 2 , further ...

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Номер записи: 84

07-01-2016 дата публикации

Devices and methods for optimized neuromodulation and their application

Номер: US20160001096A1

Автор: David J. Mishelevich

Принадлежит: Individual

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.

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Номер записи: 85

07-01-2016 дата публикации

Line-focused ultrasound transducer and high-intensity line focused ultrasound generator including same

Номер: US20160001097A1

Автор: Min-Joo CHOI, Sung-Chan Cho

Принадлежит: Korust Co ltd

The present invention has been made in an effort to provide a line-focused ultrasound transducer and a high intensity line-focused ultrasound generation device including the same in which ultrasound is focused in a line so that the treatment time can be reduced and the structure can be simplified. A line-focused ultrasound transducer which focuses in a line shape includes: a therapeutic piezoelectric member having a hollow semi-cylindrical shape; a first electrode portion which is provided on an inner surface of the therapeutic piezoelectric member; and a second electrode portion which is provided on an outer surface of the therapeutic piezoelectric member in correspondence with the first electrode portion.

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Номер записи: 86

07-01-2016 дата публикации

SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE

Номер: US20160001098A1

Автор: Pless Benjamin, Wingeier Brett

Принадлежит:

Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices. 1. A method of facilitating delivery of ultrasound energy to a brain of a patient , the method comprising:facilitating transmission of ultrasound generated by a source external to the brain, the transmission being through at least one conduit beneath a scalp of the patient, the at least one conduit having a proximal end oriented towards an outer layer of a skull of the patient and the source, and a distal end oriented towards an intracranial space.2. The method of claim 1 , wherein the at least one conduit is formed at least in part from a material that is substantially conductive to ultrasonic waves.3. The method of claim 2 , wherein the material comprises an acrylic material.4. The method of claim 1 , wherein the at least one conduit is characterized by a substantially constant radius and a substantially constant length.5. The method of claim 4 , wherein the at least one conduit comprises a lip extending beyond the substantially constant radius.6. The method of claim 1 , wherein the source is external the skull.7. A method of facilitating heat transfer from a brain of a patient claim 1 , the method comprising:facilitating transmission of heat generated by a target area of the brain through a channel toward a device external the brain, the channel having a proximal end oriented towards an outer layer of a skull of the patient and a distal end oriented towards an intracranial space, wherein the channel is associated with a mechanism for transferring heat.8. The method of claim 7 , wherein the ...

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Номер записи: 87

04-01-2018 дата публикации

DEVICE FOR NON-INVASIVE NEURO-STIMULATION BY MEANS OF MULTICHANNEL BURSTS

Номер: US20180001088A1

Автор: TASS Peter Alexander

Принадлежит:

A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons. 119-. (canceled)20. An apparatus for stimulating neurons , the apparatus comprising:a non-invasive stimulation unit configured to generate of first stimuli in a plurality of stimulation channels, such that the stimulation unit the first stimuli stimulate a neuron population in at least one of a brain and a spinal cord of a patient by the plurality of stimulation channels at respective different points in at least one of a brain and the spinal cord;a measurement unit configured to record measurement signals that represent a neuronal activity of the neuron population stimulated with the first stimuli; anda control unit that controls the stimulation unit to generate repetitive bursts that each comprise a plurality of second stimuli in each of the stimulation channels, wherein the bursts generated in different stimulation channels of the plurality of stimulation channels are delayed in time with respect to one another,wherein the stimulation unit is configured to generate the repetitive bursts such that the repetitive bursts do not reset a phase of the neuronal activity of the respective stimulated neurons,wherein the control unit is configured to determine whether the repetitive bursts generated by the stimulation unit do not reset the phase of the neuronal activity of the respectively stimulated neurons based on the measurement signals,wherein, when ...

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Номер записи: 88

02-01-2020 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR TREATING VESTIBULAR CONDITIONS

Номер: US20200001085A1

Автор: OWEN Samuel, TRUE Robert

Принадлежит: Otolith Sound Inc.

Apparatus and methods are described herein that provide a vibratory device that can apply a vibratory signal to a portion of a head of a user such that the vibratory signal can be conducted via bone to a vestibular system of the user and cause a portion of the vestibular system to move in a manner equivalent to that of a therapeutically effective vibratory signal applied to an area overlaying a mastoid bone of the user. The vibratory device can be associated with frequencies less than 200 Hz. The vibratory device can be effective at treating a physiological condition associated with the vestibular system. 1. A method , comprising:applying, via a vibratory device positioned over an area of a head of a user, a vibratory signal to the area of the head of the user such that the vibratory signal can be conducted via bone to a vestibular system of the user, the vibratory signal configured to cause a portion of the vestibular system to move in a manner equivalent to that of a vibratory signal (1) applied to an area overlaying a mastoid bone of the user and having (2) a frequency less than 200 Hz and a force level greater than 87 dB re 1 dyne and less than or equal to 100 dB re 1 dyne; andtreating, in response to applying the vibratory signal to the area of the head of the user, a physiological condition associated with the vestibular system.2. The method of claim 1 , wherein the vibratory device has a resonant frequency claim 1 , the method further comprising:supplying an electrical signal to the vibratory device to cause the vibratory device to vibrate to generate the vibratory signal that is applied to the area of the head of the user, the electrical signal having a signal frequency;measuring, using a sensor, information including at least one of: a current of the electrical signal, a voltage change of the electrical signal across the vibratory device, a magnetic field generated near the vibratory device, and an acceleration of the vibratory device; andadjusting the ...

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Номер записи: 89

04-01-2018 дата публикации

ULTRASOUND DEVICE WITH TOPICAL CONDUCTING MEDIUM

Номер: US20180001113A1

Автор: Streeter John

Принадлежит: L'OREAL

A dermal device for providing ultrasound therapy to skin is provided including: a transducer assembly including housing structure having an inner surface defining a void and configured to contact an outer portion of an area of skin of a user without contacting an inner portion of the area of skin; and an ultrasound transducer supported by the housing and configured to be disposed proximate the void, wherein the ultrasound transducer is configured to provide ultrasound energy with a focal point towards the skin. 1. A dermal device for providing ultrasound therapy to skin , the dermal device comprising:a transducer assembly including housing structure having an inner surface defining a void and configured to contact an outer portion of an area of skin of a user without contacting an inner portion of the area of skin; andan ultrasound transducer supported by the housing and configured to be disposed proximate the void,wherein the ultrasound transducer is configured to provide ultrasound energy with a focal point towards the skin.2. The dermal device of claim 1 , wherein the ultrasound transducer is configured to be adjusted within the device housing relative to the skin claim 1 ,wherein the focal point is modified based on the adjustment.3. The dermal device of claim 2 , wherein the ultrasound transducer is adjusted by adjusting the housing claim 2 ,wherein the focal point is modified based on the adjustment of the housing.4. The dermal device of claim 1 , wherein a dermal topical is configured fill the void and to serve as an ultrasound conductive medium and a therapeutic agent claim 1 ,wherein the dermal topical is one of a cosmetic, toner, cream, serum, or similar agent.5. The dermal device of claim 1 , wherein the dermal topical has a viscosity similar to that of water.6. A system for providing ultrasound therapy to skin claim 1 , the system comprising:an ultrasound transducer configured to interface with one of at least two cartridges; anda cartridge having a ...

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Номер записи: 90

04-01-2018 дата публикации

Automated ultrasound apparatus and method for noninvasive vessel recanalization treatment and monitoring

Номер: US20180001114A1

Автор: Clayton T. LARSEN, Rhodemann Li

Принадлежит: Vesselon Inc

An apparatus and method for automatically lysing a clot to recanalize vessels using ultrasound, with or without nanoparticles, microbubbles, thrombolytic drugs or other agents, is described herein. At least one ultrasound transducer with a specified geometry, bandwidth and/or transmit pulse characteristics can generate a more uniform 3-dimensional volume of defocused acoustic energy into a target area of the body. When an agent (such as, but not limited to, microbubbles) is used to lyse a clot, a certain level of ultrasound energy may be desired in order to effect certain actions or states of the agent. Bone attenuation may present an issue inhibiting sufficient ultrasound energy from reaching the agent in order to attain the desired agent action. The relative patient dimensions and location of the clot may also present an issue.

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Номер записи: 91

05-01-2017 дата публикации

METHOD FOR OPERATING A DEVICE FOR TREATMENT OF A TISSUE AND DEVICE FOR TREATMENT OF A TISSUE

Номер: US20170001042A1

Автор: Lacoste Francois

Принадлежит: Theraclion SA

A method of operating a device () for treatment of a tissue () of a living being and such a device () including a transducer () comprising at least two subtransducers (″), each for emitting a sub-beam (″) of ultrasound waves, preferably high intensity focused ultrasound waves, for irradiating the tissue (). Each of the sub-beams (″) is focused on or focusable onto a focal point (F). In order to reduce skin burns, the intersection Area (A) of a skin surface () for each sub-beam (″) is evaluated and a power (P) and/or a duration (t) of the irradiation, for every sub-transducer (″), is determined as a rate of the total power (P) or duration (t) depending from the evaluated intersection area (A). 116-. (canceled)17. A method of operating a device for treatment of a tissue of a living being , the device comprising:a transducer comprising at least two sub-transducers, each for emitting a sub-beam of ultrasound waves for irradiating the tissue, and each of the sub-beams being focused on or focusable onto a focal point;wherein the method includes the following steps:positioning the transducer such that at least one focal point of a sub-beam is located within the tissue to be treated;defining a total power and a duration of the irradiation to be delivered to the tissue;evaluating an intersection area of a skin surface with each sub-beam; anddetermining at least one of the power and the duration of the irradiation for every sub-transducer as a rate of the total power or duration depending from the evaluated intersection area.18. The method according to claim 17 , wherein the intersection area is evaluated taking into consideration a sub-beam area at a sub-transducer surface and a distance between skin surface and the sub-transducer surface.19. The method according to claim 18 , wherein the distance between skin surface and the sub-transducer surface is determined by means of A-mode echography.20. The method according to claim 17 , wherein if the intersection area is below a ...

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Номер записи: 92

02-01-2020 дата публикации

FLEXIBLE CONTROL AND GUIDANCE OF MINIMALLY INVASIVE FOCUSED ULTRASOUND

Номер: US20200001121A1

Автор: BELZBERG Micah, BREM HENRY, Cohen Alan, Ellens Nicholas, MANBACHI Amir, Siewerdsen Jeffrey, Zheng Xiaoxuan

Принадлежит:

An embodiment in accordance with the present invention provides a transducer design for minimally invasive focused ultrasound (MIFU). The present invention allows flexible control of a focused ultrasound wave using mechanical and electrical control. The transducer array is implemented on a flexible substrate that can be mechanically controlled through two or more physical configurations. As with conventional electronic “steering,” the transducer elements can be controlled electronically to provide adjustable focus of the ultrasound. The combination of mechanical and electronic control provides the device a very flexible method for delivering focused ultrasound. The invention also includes a design that allows integration of ultrasound and endoscopic image guidance. The ultrasound guidance includes anatomical visualization and functional imaging (e.g. blood flow and coagulation of vasculature). The ultrasound imaging transducer is used for thermometry within the region of interest for treatment. Endoscopic imaging allows for improved understanding of tip location in real-time. 1. A device for focused ultrasound comprising:a therapeutic ultrasound array, wherein the therapeutic ultrasound array is comprised of a number of ultrasound array elements that are configured to move relative to one another;an ultrasound transducer configured for imaging of a treatment site; anda controller for actuating movement of the therapeutic ultrasound array and movement of one or more of the number of ultrasound array elements relative to others of the number of ultrasound array elements.2. The device of further comprising mechanical movement of the therapeutic ultrasound array.3. The device of further comprising electronic movement of the therapeutic ultrasound array.4. The device of further comprising computer control of the therapeutic ultrasound array.5. The device of wherein the therapeutic ultrasound array can be controlled via movement and time delay.6. The device of further ...

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Номер записи: 93

03-01-2019 дата публикации

DEVICES AND METHODS FOR PREVENTION, MODERATION, AND/OR TREATMENT OF COGNITIVE INJURY

Номер: US20190001126A1

Автор: Evans Douglas G., Gani Matthew J., Thakkar Viral S.

Принадлежит:

This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a processor configured to: receive a test result reflecting a condition of a brain in a subject, and determine a stimulation parameter based on the test result; and a stimulator configured to stimulate a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. 1. A method for treating a subject , comprising:obtaining a test result reflecting a condition of a brain in the subject;determining a stimulation parameter based on the test result; andstimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject.2. The method of claim 1 , wherein the nerve is a first nerve claim 1 , and the method further comprises stimulating a second nerve claim 1 , wherein stimulation of the second nerve initiates a biological response in the brain that reduces a level of a causing factor of a brain injury.3. The method of claim 2 , wherein the second nerve is a vagus nerve.4. The method of claim 2 , wherein stimulation of the second nerve affects signaling from the second nerve to the brain or a lung in the subject.5. The method of claim 2 , wherein the second nerve is stimulated by an external nerve stimulator.6. The method of claim 5 , wherein the external nerve stimulator is positioned on a skin area adjacent to a vagus nerve in the subject.7. The method of claim 2 , wherein the second nerve is stimulated by an implantable nerve stimulator.8. The ...

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Номер записи: 94

03-01-2019 дата публикации

CONTROLLING EAR STIMULATION IN RESPONSE TO ELECTRICAL CONTACT SENSING

Номер: US20190001128A1

Автор: Goodall Eleanor V., Hyde Roderick A., Ishikawa Muriel Y., JR. Lowell L., Kare Jordin T., Kitzan Melanie K., Leuthardt Eric C., Malamud Mark A., Malaska Stephen L., Myhrvold Nathan P., Scheid Brittany, Sharadin Katherine E., Sweeney Elizabeth A., Tegreene Clarence T., Whitmer Charles, Wood, Wood Victoria Y.H.

Принадлежит:

Systems and related methods for controlling an ear stimulation device with a personal computing device, in response to determination of electrical contact of an electrode in a stimulator earpiece with an ear of a user of the personal computing device, are described. If the electrode is not in good electrical contact with the ear of the user, delivery of the stimulus is prevented and the user is notified of the status of the electrode. In various aspects, the user is instructed to reposition the earpiece or replace, clean, moisten, or apply gel to at least a portion of the electrode. 135.-. (canceled)36. A method of controlling an ear stimulation device with a personal computing device , comprising:receiving at least one first signal at a personal computing device used by a subject, wherein the at least one first signal is indicative of at least one of delivery of a pharmaceutical to the subject, delivery of a nutraceutical to the subject, an event in a game played by the subject, a user input to a game by the subject, a user input provided to a virtual reality system by the subject, an event experienced by the subject in a virtual reality system, a user input to the computing device by the subject indicative of a mental or emotional state of the subject, a user input to a computing device by the subject in response to a query or prompt, genome information of the subject, or microbiome information of the subject;determining a neural stimulus control signal based at least in part on the at least one first signal with stimulation control circuitry in the personal computing device, the neural stimulus control signal configured to control delivery by an external neural stimulator of a neural stimulus configured to stimulate at least one nerve innervating a pinna of the subject;outputting the neural stimulus control signal from the personal computing device to an ear stimulation device including the external neural stimulator carried on the pinna of the subject; ...

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Номер записи: 95

03-01-2019 дата публикации

Apparatus and cosmetic method for providing cooling to a skin tissue treatment head

Номер: US20190001145A1

Автор: Zion Azar

Принадлежит: Pollogen Ltd

A device for cooling the skin tissue of a patient during a procedure using energy includes a mat-like structure, the mat-like structure having a bottom wall, a top wall and upstanding walls connecting the top wall and the bottom wall, the walls defining an enclosed volume; it also includes one or more electrodes positioned to protrude from the bottom wall and extend through the volume for connection to a source of energy; further, the volume defines a space for holding a cooling substance for cooling the one or more electrodes and the skin tissue during an energy-based procedure.

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Номер записи: 96

07-01-2016 дата публикации

MULTILAYER ULTRASOUND VIBRATION DEVICE, PRODUCTION METHOD FOR MULTILAYER ULTRASOUND VIBRATION DEVICE, AND ULTRASOUND MEDICAL APPARATUS

Номер: US20160001326A1

Автор: Ito Hiroshi

Принадлежит: OLYMPUS CORPORATION

A multilayer ultrasound vibration device includes a plurality of piezoelectric bodies and a plurality of electrode layers stacked together, wherein: the plurality of piezoelectric bodies are formed of a plurality of monocrystalline piezoelectric bodies; and widths d and d of outer surfaces of the plurality of electrode layers in a stacking direction is made larger than a spacing distance d of the stacked plurality of monocrystalline piezoelectric bodies in the stacking direction. 1. A multilayer ultrasound vibration device , comprising a plurality of piezoelectric bodies and a plurality of electrode layers stacked together , wherein: the plurality of piezoelectric bodies are formed of a plurality of monocrystalline piezoelectric bodies; and width of outer surfaces of the plurality of electrode layers in a stacking direction is made larger than a spacing distance of the stacked plurality of monocrystalline piezoelectric bodies in the stacking direction.2. The multilayer ultrasound vibration device according to claim 1 , wherein only the outer surfaces of the plurality of electrode layers which are connected with a wiring line adapted to supply a drive signal have the width in the stacking direction made larger than the spacing distance of the plurality of monocrystalline piezoelectric bodies in the stacking direction.3. The multilayer ultrasound vibration device according to claim 1 , wherein chamfered portions are formed on side edges of the plurality of monocrystalline piezoelectric bodies such that an outward-side thickness is larger than an inward-side thickness of the plurality of electrode layers and the width of the plurality of electrode layers in the stacking direction is made larger on a side of the outer surfaces of the plurality of electrode layers.4. The multilayer ultrasound vibration device according to claim 2 , wherein: a prismatic stacked structure is formed by the plurality of monocrystalline piezoelectric bodies and the plurality of electrode ...

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Номер записи: 97

03-01-2019 дата публикации

3d conformal radiation therapy with reduced tissue stress and improved positional tolerance

Номер: US20190001154A1

Автор: Kobi Vortman, Yoav Lévy

Принадлежит: Individual

An approach for enhancing radiation treatment of target tissue includes identifying a target volume of the target tissue; causing disruption of vascular tissue in a region confined to the target volume so as to define the target volume; based at least in part on the disruption of the vascular tissue, determining a radiation treatment plan having a reduced radiation dose for treating the target tissue; and exposing the target volume to the reduced radiation dose based on the radiation treatment plan.

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Номер записи: 98

03-01-2019 дата публикации

STEERABLE HIGH-INTENSITY FOCUSED ULTRASOUND (HIFU) ELEMENTS

Номер: US20190001159A1

Автор: Chen Kailiang, Ralston Tyler S., Sanchez Nevada J., West Lawrence C., Zahorian Jaime Scott

Принадлежит: Butterfly Network, Inc.

Ultrasound devices configured to perform high-intensity focused ultrasound (HIFU) are described. An ultrasound device may include HIFU units configured to emit high acoustic intensities. Multiple ultrasound devices may be disposed on a substrate, which may be configured to be flexed so that the direction of emission of the ultrasound devices can be mechanically controlled. Additionally, or alternatively, the ultrasound beams produced by different ultrasound devices may be electronically oriented by adjusting the phases of the signals with which each element of a device is driven. For example, multiple phased arrays of ultrasound devices may be used to concentrate ultrasound energy into a desired location. In some embodiments, the time at which different ultrasound signals are emitted may be controlled, for example to ensure that the combined signal has at least a desired intensity. 1. An apparatus comprising:a substrate having a plurality of support portions including a first support portion and a second support portion, wherein the first support portion is connected to the second support portion through a coupler;a first plurality of ultrasound elements configured as high-intensity focused ultrasound (HIFU) elements and disposed on the first support portion of the substrate; anda second plurality of ultrasound elements configured as HIFU elements and disposed on the second support portion of the substrate.2. The apparatus of claim 1 , wherein the first and second plurality of ultrasound elements comprise capacitive micromachined ultrasound transducers (CMUT).3. The apparatus of claim 1 , wherein the coupler is selected from the group consisting of a hinge claim 1 , a spring claim 1 , a flexure claim 1 , a beam claim 1 , a joint and a sphere.4. The apparatus of claim 1 , further comprising a third plurality of ultrasound elements configured to receive ultrasound signals and disposed on the first support portion of the substrate.5. The apparatus of claim 4 , wherein ...

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Номер записи: 99

13-01-2022 дата публикации

BRAIN STIMULATION SYSTEM INCLUDING DIAGNOSTIC TOOL

Номер: US20220008727A1

Автор: "OConnell Dan", FLAHERTY J. Christopher, Langevin Todd, Reymers Donald E.

Принадлежит: Functional Neuromodulation, Inc.

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided. 1a stimulator for stimulating brain tissue;a controller for setting stimulation parameters comprising at least one test stimulation parameter of the stimulator and at least one treatment stimulation parameter of the stimulator; anda diagnostic tool for measuring at least one patient parameter and producing diagnostic data representing the at least one measured patient parameter;wherein the stimulator is constructed and arranged to deliver test stimulation energy to the brain tissue based on the at least one test stimulation parameter and to deliver treatment stimulation energy to the brain tissue based on the at least one treatment stimulation parameter;wherein the at least one treatment stimulator parameter is determined based on the diagnostic data; andwherein the system is constructed and arranged to treat at least one of a neurological disease or a neurological disorder.. A system for treating a patient comprising: This application is a continuation of U.S. patent application Ser. No. 15/714,782, filed Sep. 25, 2017, which is a continuation of U.S. patent application Ser. No. 14/917,917, filed Apr. 8, 2016, now U.S. ...

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Номер записи: 100