СПОСОБ ГРАНУЛИРОВАНИЯ МИНЕРАЛЬНЫХ УДОБРЕНИЙ

Изобретение относится к способу гранулирования минеральных удобрений из расплава, включающему дробление расплава на капли, кристаллизацию капель при их свободном падении в противотоке охлаждающего воздуха в грануляционной башне, который выводят из зоны кристаллизации, подачу его в промывочную колонну на стадию очистки и охлаждения орошением в противотоке с компримирующим его за счет спутного течения воздуха и факелом потоком охлаждающей промывочной жидкостью, и возвращение охлажденного и пропускного воздуха в нижнюю часть зоны кристаллизации грануляционной башни под созданным спутным течением потока падающих капель охлажденной промывочной жидкости давлением, необходимым для преодоления сопротивления, возникающего в грануляционной башне при падении в ней капель расплава, и характеризующемуся тем, что плотность орошения промывочной жидкостью осуществляется в зависимости от необходимого напора воздуха по соотношению:, где: q - среднее значение плотности орошения промывочной жидкости в зоне ...

СПОСОБ ИЗГОТОВЛЕНИЯ ДИСПЕРСИОННЫХ ПОРОШКОВ

Предметом изобретения является способ изготовления дисперсионных порошков посредством распылительной сушки водных полимерных дисперсий и добавления средств против слеживания, отличающийся тем, что имеющееся в агломерированной форме средство против слеживания с размером частиц от 10 мкм до 250 мкм, или с размером частиц от 5 мм до 5 см в случае агломератов в форме экструдатов, полностью или частично посредством транспортировочного газа вводят в процесс распылительной сушки и измельчают до размера частиц от 0,01 мкм до 5 мкм, или в случае экструдатов до размера частиц от 2 мкм до 60 мкм. 14 з.п. ф-лы, 2 ил.

СПОСОБ ГРАНУЛИРОВАНИЯ И УСТРОЙСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ

Изобретение относится к гранулированию жидкого или полужидкого вещества. В заявке описан способ гранулирования, в котором жидкость распыляется в грануляционную башню посредством вращающегося ковша для гранулирования, имеющего перфорированную боковую стенку. Струи жидкости, выходящие из перфорированной боковой стенки, подвергаются воздействию вибрации в направлении оси (А-А) грануляционной башни, в то время как воздействие вибрации на массу жидкости, остающуюся внутри ковша, в основном исключается. Кроме того, раскрыто соответствующее устройство, в котором перфорированная боковая стенка ковша для гранулирования соединена с вызывающими вибрацию средствами и имеет гибкое соединение с рамой ковша. Изобретение позволяет улучшить монодисперсию капелек жидкости в грануляционной башне. 2 н. и 14 з.п. ф-лы, 2 ил.

УСТРОЙСТВО ДЛЯ ПОЛУЧЕНИЯ ГРАНУЛ ИЗ РАСПЛАВА

Изобретение предназначено для получения стеклянных гранул сферической или полусферической формы, применяемых в качестве стеклообразного удобрения пролонгированного действия. Устройство для получения гранул из расплава включает нагревательный модуль 1, содержащий тигель 3 с донным патрубком 4, приемный модуль 2, содержащий входную емкость в виде перевернутого конуса 7, компрессор 13, накопитель 16. Внутри конуса вблизи его верхнего края для приема падающих капель расплава установлена платформа-демпфер 18 в виде тонкой металлической пластины, плоскость которой обращена внутрь конуса и наклонена относительно горизонтали и вертикали. Изобретение позволяет упростить процесс образования гранул из расплава, уменьшить габариты устройства и повысить качество образованных гранул по форме и идентичности их размеров. 1 ил.

СПОСОБ И УСТРОЙСТВО ГРАНУЛИРОВАНИЯ С РЕГУЛИРОВАНИЕМ ДАВЛЕНИЯ

Изобретение относится к способу и устройству регулирования давления жидкости или пульпы. Описаны способы и устройство гранулирования, включающие динамическое регулирование давления в приемнике для улучшения контроля над качеством гранул и их гранулометрическим составом. В одном из вариантов осуществления настоящего изобретения осуществляется регулирование давления в свободном пространстве над объемом жидкости или пульпы с тем, чтобы обеспечить более точное регулирование давления жидкости или пульпы в приемнике. В другом варианте осуществления настоящего изобретения для обеспечения более точного регулирования давления жидкости или пульпы в приемнике используется устройство для создания осевого восходящего потока. Изобретение позволяет повысить качество и гранулометрический состав произведенных гранул. 2 н. и 8 з.п. ф-лы, 9 ил.

СПОСОБ КОНТРОЛЯ РАЗМЕРА РАСПЫЛЕННЫХ КАПЕЛЬ В РАСПЫЛИТЕЛЬНОМ НАСАДОЧНОМ УСТРОЙСТВЕ ДЛЯ РАСПЫЛИТЕЛЬНОЙ СУШКИ, АППАРАТ ДЛЯ РАСПЫЛИТЕЛЬНОЙ СУШКИ И НАСАДКА К НЕМУ

Изобретение относится к пищевой промышленности. Способ контроля размера распыленных капель в распылительном насадочном устройстве, в частности, для изготовления пищевых порошков, подаваемых в распылительную насадку, включающий следующие стадии: a) получение пастообразного продукта, подлежащего распылению с помощью распылительной насадки; b) непрерывное определение сдвиговой вязкости (η) пастообразного продукта, подаваемого в распылительную насадку; c) определение массового расхода (Qm) пастообразного продукта, подаваемого в распылительную насадку; d) определение статического давления (P) пастообразного продукта, подаваемого в распылительную насадку; e) определение плотности (ρ) пастообразного продукта, подаваемого в распылительную насадку; f) передачу данных, полученных на стадиях b)–е), в устройство управления, содержащее компьютер и память; g) вычислительную обработку управляющих данных для регулирования распылительной насадки на основании данных, полученных на стадиях b)–е), и параметров ...

ПРОИЗВОДСТВО ТВЕРДОГО ХИМИЧЕСКОГО ПРОДУКТА

Изобретение относится к способу отверждения химического продукта в форме плава для получения твердого продукта в виде прилов или гранул. В частности, изобретение относится к сфере производства твердой мочевины. В заявке описан способ отверждения химического продукта, имеющего форму плава, при осуществлении которого: подвергают первый поток химического продукта приллированию с получением прилов различного диаметра; подают эти прилы в сортировочное устройство, в котором они разделяются по диаметру на по меньшей мере первую фракцию и вторую фракцию, причем средний диаметр прилов первой фракции меньше среднего диаметра прилов второй фракции, подвергают второй поток химического продукта и первую фракцию прилов гранулированию с получением гранул. Изобретение позволяет получить твердый продукт с улучшенными характеристиками в части размеров и механической прочности по сравнению с продуктом, получаемым обычными способами. 3 н. и 3 з.п. ф-лы, 1 ил.

Способ грануляции веществ

Изобретение относится к химической промышленности и металлургии, а именно к жидкостной грануляции, и предназначено для производства сферических гранул веществ. Грануляции подвергают вещества, температура плавления которых не превышает 1150°С. Способ осуществляют в устройстве, содержащем реактор, состоящий из корпуса и крышки, подключенный к системе подачи инертного газа, с размещенным внутри тиглем с исходным веществом с по крайней мере одним отверстием, печной блок и колбы первого и второго контура охлаждения. При сборке тигель помещают в корпус реактора, а нижний край корпуса реактора погружают с образованием жидкостного затвора в колбу первого контура охлаждения с охлаждающей жидкостью, которую совмещают с колбой второго контура охлаждения, предварительно заполнив ее хладагентом. Охлаждающую жидкость для первого контура используют иную по физико-химическим свойствам, чем хладагент второго контура охлаждения. Реактор заполняют инертным газом, создают избыточное давление и циркуляцию инертного ...

СПОСОБ ПОЛУЧЕНИЯ ПОРОШКОВ СЛОЖНОЛЕГИРОВАННЫХ СПЛАВОВ СО СФЕРИЧЕСКОЙ ФОРМОЙ ЧАСТИЦ

Изобретение относится к порошковой металлургии, а именно к способам получения металлических порошков сложнолегированных сплавов со сферической формой частиц, которые могут применяться в порошковом и аддитивном производствах. Способ включает сфероидизацию в потоке термической плазмы порошков осколочного типа. Осколочные порошки получают из аморфных лент толщиной 40-60 мкм, которые отжигают в условиях вакуума с разрежением не менее (1÷5)×10-5 Торр до кристаллического состояния для их охрупчивания. После чего кристаллические, охрупченные в процессе термообработки ленты размалывают в шаровой планетарной мельнице в среде чистого спирта и затем методом ситового анализа выделяют фракцию 40-100 мкм. Сфероидизацию проводят в плазме аргона или аргоно-водородной смеси. Обеспечивается получение порошков с высокой степенью сферичности и узким распределением гранулометрического состава с максимальным выходом заданной фракции после сфероидизации, что уменьшает количество брака при изготовлении конечных ...

Установка для получения мелкодисперсных порошков и способ осуществления

Группа изобретений относится к получению композитных дисперсных материалов, применяемых в химической, фармацевтической, косметической и пищевой промышленности, а также в микроэлектронике, материаловедении и аддитивных технологиях. Установка для получения мелкодисперсных порошков, работающая по методу сверхкритического антисольвентного осаждения, содержит полость с источником вещества, полость для образования частиц вещества с фильтром, соединенную вертикально с гидроумножителем через обратный клапан и сопло, а также с источником антирастворителя, устройство подачи вещества от источника в полость для образования частиц посредством гидроумножителя, управляемого через гидравлический распределитель от источника гидравлической жидкости. Подаваемое вещество является вязким сырьем, устройство подачи вещества от источника в полость гидроумножителя представляет собой два и более параллельно расположенных сосуда высокого давления, входные порты которых подключены к источнику сжатого CO2 с давлением ...

ГРАНУЛЯЦИОННАЯ БАШНЯ

Изобретение относится к установкам для гранулирования продуктов, в частности удобрений, из их расплавов. Предложена грануляционная башня, включающая пустотелый корпус, разбрызгиватель расплава, окна для подачи воздуха с направляющими пластинами, расположенные над приемно-направляющим устройством, транспортер для выгрузки гранул. Приемно-направляющее устройство выполнено из отдельных листов, расположенных в двух плоскостях вдоль противоположных сторон транспортера с наклоном к нему. Листы ориентированы перпендикулярно к транспортеру. К каждому из листов присоединен постоянно работающий вибратор, вызывающий его вибрацию. Часть направляющих пластин, расположенных в окнах для подачи воздуха, может быть установлена с наклоном таким образом, что внутренний край пластин размещен ниже наружного края. Приемно-направляющее устройство может быть выполнено из гофрированных листов и/или иметь антиадгезионное покрытие. Изобретение позволяет минимизировать налипание незатвердевшего материала на поверхности ...

СПОСОБ И УСТРОЙСТВО ДЛЯ ГРАНУЛИРОВАНИЯ ЖИДКОСТИ, В ЧАСТНОСТИ ДЛЯ ГРАНУЛИРОВАНИЯ МОЧЕВИНЫ

... 1. Способ гранулирования жидкой фазы, в котором создают полидисперсный поток капелек жидкой фазы с нисходящим движением в контакте с воздухом для отверждения вдоль в основном вертикального тракта процесса гранулирования, причем в этом полидисперсном потоке капельки маленького размера отверждаются, образуя твердые частицы, которые увеличиваются в размере при столкновении с другими капельками жидкости.2. Способ по п. 1, в котором полидисперсный поток капелек жидкой фазы включает капельки, имеющие характеристический размер или диаметр, изменяющийся в пределах от 0,1 мм до приблизительно 2,5 мм и предпочтительно от 0,2 мм до 2 мм.3. Способ по п. 1, в котором подают по меньшей мере часть воздуха вдоль тракта (6) процесса гранулирования через воздухопроницаемую стенку (8), которая определяет границы по меньшей мере начальной части указанного тракта.4. Способ по п. 1, в котором все количество подаваемой жидкой фазы в виде полидисперсного потока капелек вводят в верхнюю часть указанного тракта ...

СПОСОБ ПОЛУЧЕНИЯ СУХИХ ЭКСТРАКТОВ

... 1. Способ получения сухих экстрактов из жидкого экстракта и по меньшей мере одного дополнительного вещества путем процесса распылительной сушки, в котором указанное по меньшей мере одно дополнительное вещество вводят в процесс распылительной сушки в сухом виде во время процесса распылительной сушки. 2. Способ по п.1, в котором по меньшей мере одно дополнительное вещество впрыскивают в виде сухого порошка. 3. Способ по п.1, в котором указанный жидкий экстракт представляет собой экстракт лекарственного растения. 4. Способ по п.1, в котором указанное по меньшей мере одно дополнительное вещество представляет собой галеновый вспомогательный агент. 5. Способ по п.4, в котором указанный вспомогательный агент выбирают из группы, состоящей из лактозы, мальтодекстрина, декстрина, сухой глюкозы, крахмала, микрокристаллической целлюлозы, силикатированной/силикатизированной микрокристаллической целлюлозы, Povidone®, полиэтиленгликоля, фосфата кальция, стеарата магния, осажденной кремниевой кислоты, ...

СПОСОБ ПОЛУЧЕНИЯ ГОМОГЕННЫХ, ВЫСУШЕННЫХ РАСПЫЛЕНИЕМ ТВЕРДЫХ АМОРФНЫХ ДИСПЕРСИЙ ЛЕКАРСТВЕННОГО СРЕДСТВА С ИСПОЛЬЗОВАНИЕМ МОДИФИЦИРОВАННОЙ УСТАНОВКИ СУШКИ РАСПЫЛЕНИЕМ

... 1. Способ получения фармацевтической композиции, включающий стадии: (а) получения исходного раствора, содержащего лекарственное средство, повышающий концентрацию полимер и растворитель; (b) направления указанного исходного раствора в установку распылительной сушки, включающую (i) сушильную камеру, имеющую объем Vdryer и высоту Н, (ii) распыляющее средство для распыления указанного исходного раствора на капли, (iii) источник нагретого осушающего газа для высушивания указанных капель при этом указанный источник доставляет указанный осушающий газ в указанную сушильную камеру при скорости потока G, и (iv) газо диспергирующее средство для диспергирования указанного осушающего газа в указанную сушильную камеру, при этом указанное газо диспергирующее средство создает организованный поршнеобразный ввод потока указанного осушающего газа, где Vdryerизмеряется, м3; Н составляет, по меньшей мере, 1 м; G измеряется, м3/с; и соблюдается следующая математическая взаимозависимость (с) распыления указанного ...

СПОСОБ РАСПЫЛИТЕЛЬНОЙ КОНДЕНСАЦИИ ДЛЯ ПОЛУЧЕНИЯ СМОЛ

... 1. Способ распылительной конденсации для получения подвергнутых сушке порошкообразных смол из меламина, мочевины или их смеси и, по меньшей мере, одного альдегида, отличающийся тем, что распылительную конденсацию осуществляют капельным распылением и морфологию формирующихся частиц образующейся порошкообразной смолы изменяют, оказывая целенаправленное воздействие на их параметры, в соответствии с которым образуются вспененные, преимущественно сферические частицы с гладкими участками поверхности или без них. 2. Способ по п.1, отличающийся тем, что капельным распылением является вибрационное капельное распыление. 3. Способ по п.1, отличающийся тем, что целенаправленное воздействие на параметры формирующихся частиц смолы, которое приводит к изменению их морфологии, оказывают регулированием показателя рН исходного раствора компонентов перед распылительной конденсацией. 4. Способ по п.1, отличающийся тем, что перед началом распылительной конденсации к исходному раствору компонентов добавляют ...

СПОСОБ ГРАНУЛИРОВАНИЯ И УСТРОЙСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ

... 1. Способ гранулирования выбранного вещества в жидком состоянии, в котором это жидкое вещество подают во вращающийся ковш (15) для гранулирования, расположенный внутри грануляционной башни (1), вмещающий заданную жидкую массу указанного вещества и имеющий перфорированную боковую стенку (15а), через которую жидкое вещество распыляется из ковша для гранулирования в грануляционную башню в виде струй жидкости, отличающийся тем, что струи жидкости подвергают вибрации в направлении оси (А-А) грануляционной башни (1), в то время как вибрация содержащейся в ковше (15) жидкой массы в основном исключается, причем струям жидкости вибрация передается в результате воздействия вибрации на перфорированную боковую стенку (15а), а остальные части ковша для гранулирования изолированы от указанного воздействия вибрации. ! 2. Способ по п.1, в котором выбранным веществом является мочевина. ! 3. Устройство для гранулирования жидкого или полужидкого вещества, содержащее грануляционную башню (1) и расположенный ...

ВИБРАЦИОННАЯ ГРАНУЛЯЦИОННАЯ ЕМКОСТЬ ДЛЯ ГРАНУЛИРОВАНИЯ ЖИДКОГО ВЕЩЕСТВА

... 1. Вибрационная грануляционная емкость (15) для гранулирования жидкого вещества (U), включающая корпус с перфорированной боковой стенкой (15а), в основном симметричной по отношению к оси (А-А), и вызывающий вибрацию двигатель (V), отличающаяся тем, что вызывающий вибрацию двигатель (V) установлен с возможностью обеспечения во время работы вызывающей вибрацию силы (R), имеющей в основном постоянное направление по упомянутой оси (А-А) емкости (15). ! 2. Грануляционная емкость по п.1, у которой вызывающий вибрацию двигатель (V) установлен с возможностью обеспечения нескольких вращающих сил (F1, F2), взаимно уравновешенных в направлениях, перпендикулярных упомянутой оси (А-А). ! 3. Грануляционная емкость по п.2, у которой вызывающий вибрацию двигатель (V) установлен с возможностью обеспечения сил (F1, F2) вращения в противоположных направлениях и в одной плоскости (t1, t2), в основном параллельной упомянутой оси (А-А). ! 4. Грануляционная емкость по п.3, у которой вызывающий вибрацию двигатель ...

СПОСОБ ПОУЧЕНИЯ ПОЛИАМИДА, НЕЙЛОНОВАЯ СОЛЬ, ИСПОЛЬЗУЕМАЯ В НЕМ, И СПОСОБ ПОЛУЧЕНИЯ ТАКОЙ СОЛИ

СПОСОБ ИЗГОТОВЛЕНИЯ ДИСПЕРСИОННЫХ ПОРОШКОВ

... 1. Способ изготовления дисперсионных порошков посредством распылительной сушки водных полимерных дисперсий и добавления средств против слеживания, отличающийся тем, что имеющееся в агломерированной форме средство против слеживания с размером частиц от 10 мкм до 250 мкм, или с размером частиц от 5 мм до 5 см в случае агломератов в форме экструдатов, полностью или частично посредством транспортировочного газа вводят в процесс распылительной сушки и измельчают до размера частиц от 0,01 мкм до 5 мкм, или в случае экструдатов до размера частиц от 2 мкм до 60 мкм.2. Способ по п. 1, отличающийся тем, что измельчение средства против слеживания происходит посредством встроенной в транспортировочный трубопровод ударной мельницы.3. Способ по п. 1, отличающийся тем, что измельчение средства против слеживания происходит за счет того, что насыщенный средством против слеживания транспортировочный газ направляют на одну или несколько отбойных пластин.4. Способ по п. 3, отличающийся тем, что отбойную пластину ...

СПОСОБ ГРАНУЛИРОВАНИЯ ОКАТЫВАНИЕМ

СПОСОБ И УСТРОЙСТВО ДЛЯ ПОЛУЧЕНИЯ ПОРОШКОВЫХ ЧАСТИЦ ПУТЕМ АТОМИЗАЦИИ СЫРЬЕВОГО МАТЕРИАЛА В ФОРМЕ УДЛИНЕННОГО ЭЛЕМЕНТА

Способ обезвоживания хлористого магния

VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON TEILCHEN

VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON FESTEN TEILCHEN

PROCESS AND APPARATUS FOR THE PRODUCTION OF PERFECTLY SPHERICAL AND POROUS GRANULES, AND GRANULES PRODUCED IN THIS WAY

Verfahren und Vorrichtung zur Herstellung von zweifarbigen Kugeln für eine Drehkugelanzeige

METHODE UND VORRICHTUNG ZUR KUEHLUNG VON FESTEN TEILCHEN.

Verfahren zur Herstellung von partikelförmigem Material

Die Erfindung betrifft ein Verfahren zur Herstellung von partikelförmigem Material aus der Schmelze mit: DOLLAR A - Aufschmelzen des Materials, DOLLAR A - inniges Mischen der Materialschmelze mit einem Gas; DOLLAR A - schlagartiges Expandieren der Gas/Flüssigkeitsmischung unter Zugabe weiteren Gases unter Verfestigung der gebildeten Materialtröpfchen zu einem Materialpulver in einen Raum niedrigeren Drucks als die Gas/Flüssigkeitsmischung; und DOLLAR A - Sammeln des so hergestellten Materialpulvers.

Verfahren zur Herstellung von anorganischen Mikrokugeln und Glasmikrohohlkugeln

Vorrichtung und Verfahren zum Herstellen von zweifarbigen Mikrokugeln

VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON TEILCHEN

VERFAHREN UND VORRICHTUNG ZUM VERTEILEN EINER FLUESSIGKEIT IN EINEM GAS- ODER DAMPFFOERMIGEN MEDIUM

VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON AUS IM WESENTLICHEN SPHÄRISCHEN PARTIKELN GEBILDETEN PULVERN

Vorrichtung zum Verdüsen eines Schmelzestrahls und Verfahren zum Verdüsen von hochschmelzenden Metallen und Keramikschmelzen

Vorrichtung zum Verdüsen eines Schmelzestrahls mit einer mit Schmelze versorgten Schmelzedüse, deren Austrittsöffnung über einer Öffnung einer Lavaldüse angeordnet ist oder in diese hineinragt und mit einer den aus der Schmelzedüse austretenden Schmelzestrahl begleitenden und mittels der Lavaldüse beschleunigten Gasströmung, dadurch gekennzeichnet, dass die Schmelzedüse (2, 24) von einer Wärmeisolierung (10, 11, 13, 21, 29) umgeben ist, die zur Abschirmung des unteren Bereichs der Schmelzedüse (2, 24) gegen die Gasströmung bis in die Nähe der Lavaldüse (6, 27) reicht, und nur die Austrittsöffnung (5, 26) der Schmelzedüse (2, 24) freilässt.

Spherical particle or fibre mfr. from melts - esp. from molten metals, fluxes or slags, using spinning plant to obtain solid particles with exact size

The particles or fibres have specific dimensions, and are obtd. from a melt flowing at a prescribed rate through the bottom outlet of a tundish onto a spinning rotor plate. The plate forms a thin film on the rotor plate, the dia. and speed of which produce free linear streams of the melt; and the stream forms spheroids or fibres of specific size. The tundish outlet pref. has a radius of Ro mm, and is located above the axis of the rotor plate by a distance (Ho) between Ro/2mm and (Ro/2) + 2mm. The pref. rotor plate is made of silica, graphite, SiC, Si3N4, Zr02, chamotte, A1203, or MgO; and may consist of several plates. The rotor is pref. located in a casing with ring inlets for gas. All the spinning conditions can be quantitatively controlled by theoretical calculations.

VERFAHREN ZUR HERSTELLUNG VON NANO- UND MIKRO-TEILCHEN

Kristallierte Perlen aus einem Produkt das unterkühlt werden kann und Verfahren zu ihrer Herstellung

Vorrichtung zum UEberziehen von Tabletten

MELT ATOMIZATION

FILLERS

... 1426801 Spherical filler PHILADELPHIA QUARTZ CO 5 Feb 1973 [3 Feb 1972 (2) 17 March 1972 12 May 1972] 5555/73 Heading C1A A hollow sphere suitable for use as a filler in polymer compositions comprises the reaction product of a polyborate or polyphosphate and an alkali metal silicate in which the weight ratio of polysalt solids to alkali metal silicate solids is 0À02-3À0 : 1 0. The alkali metal silicate may be sodium silicate having an SiO 2 /Na 2 O weight ratio of 1À5-4À0 : 1À0 or potassium silicate having an SiO 2 /K 2 O weight ratio of 1À5-4À2 : 1À0. The preferred polysalts are ammonium pentaborate, in which case the ratio of pentaborate to silicate is 0À03-0À5 : 1À0; sodium pentaborate, in which case the ratio of pentaborate to silicate is 0À02-0À3 1À0 or sodium hexametaphosphate in which case the ratio of metaphosphate to silicate is 1À0-3À0 : 1À0. The spheres may be made by a spray drying process as described in Specification 1,426,802. The dry cells preferably have a water content ...

Powder coating compositions and process for the manufacture thereof

Improved prilling process

Explosive grade ammonium nitrate (EGAN) prills are made by a process that comprises the steps of: a. continuously spraying a 95 to 98% by weight solution/melt of ammonium nitrate (or a mixture of ammonium nitrate and minor proportions of one or more other EGAN - acceptable nitrates) in/with water under spray-head conditions causing the emergent jets to break into cascades of substantially mono-sized droplets; b. allowing the formed droplets to fall within a vertical duct; c. continuously feeding a stream of cooling gas upwards through the duct, the temperature difference of the gas flow between its inlet to the duct and its outlet from the duct being at least 60 DEG C; the falling velocity of the prills being at most 3 metres/second, the upward gas flow velocity being e.g. 6 m/s for 2 mm prill and 9 m/s for 3 mm prill and, optionally, recycling the gas. ade b ...

Method of particle formation

Method of particle formation

Particle formation method and apparatus

A method for preparing a target substance in particulate form comprises introducing a solution or suspension of a target substance and a compressed anti-solvent fluid into a particle formation vessel through separate first and second inlets so as to allow the anti-solvent fluid to extract the target substance from the solution or suspension and form particles of the target substance. The compressed anti-solvent fluid is introduced into the particle formation vessel at a sonic, near-sonic or supersonic velocity. The velocity of the anti-solvent fluid may be in the region of Mach 0.8-1.5 and the anti-solvent fluid may be introduced into the particle formation vessel as a single stream through a convergent nozzle. The anti-solvent fluid may be super-critical or near-critical and it may have a temperature and pressure sufficiently higher than the particle formation vessel as to ensure that Joule-Thomson cooling of the anti-solvent fluid as it enters the particle formation vessel does not lower ...

A method of and apparatus for atomising a liquid stream

Melt atomization with reduced gas flow and apparatus for atomizing

A method for generating prime powder from a material having a high melting point and apparatus for generating the powder is taught. The apparatus includes a melt delivery tube. The melt of the high melting material is introduced into the tube and exits from the tube into an atomization zone. Gas is delivered to the zone at high pressure as a stream to atomize the melt. Pursuant to the present invention, the atomizing gas is directed against the lower end of the melt delivery tube and it is deflected from the melt delivery tube into contact with the descending high temperature melt. A concave surface is provided on the end of the melt delivery tube to deflect the gas along the tube surface to minimize Eddy currents and provide better control of the atomization process.

PROCESS FOR THE GRANULATING OF SULPHUR AND A SULPHUR GRANULATOR

Particle information

Improvements relating to nanodisperse compositions

Process and Apparatus for Producing a Particulate Product

... 1,189,543. Spray-drying. COLGATE-PALMOLIVE CO. 9 July, 1968 [19 July, 1967], No. 32619/68. Heading B1B. [Also in Divisions C5] A countercurrent spray drying process for producing a particulate product substantially free from fines and agglomeration comprises: (1) forming a first stream of liquid mixture which is dryable to form solid particles; (2) passing this stream to a point of entry in an upper portion of a drying tower; (3) forming a second similarly dryable liquid mixture and passing it to a point of entry in a lower portion of the tower; (4) simultaneously spraying the two streams downwardly from their points of entry into an upwardly flowing stream of drying gas whereby the spray droplets are dried to solid particles; (5) removing the dried mixture of discrete particles from the tower. The respective feed streams may be differently coloured to give a multicoloured product e.g. a detergent composition; first stream preferably forms the major proportion of the final product and is ...

Improved spraying means for drying, granulating, crystallizing and solidifying slurries or solutions, particularly of soaps, detergents and the like

... A substantially cylindrical spray drying chamber 11 has its upper part in the form of a truncated cone and is provided, within this upper part, with a hood 10 having its walls parallel to the conical walls of the chamber; inside this hood is mounted a nozzle 9 through which the solution to be treated is sprayed into the chamber by means of a pump; just below the hood are mounted a plurality of nozzles 8 through which the solution is sprayed by means of compressed air; and ducts are provided for introducing the treating gas into the hood and into the top of the chamber. The apparatus may be used for drying, granulating, crystallizing and cooling solutions or slurries of industtrial products. The spray drying of soaps or synthetic detergents to produce hollow particles is referred to. The solution or slurry to be dried is blended in mixers 1, and is then pumped through filter 3 to nozzle 9, through which it is sprayed by the pressure ...

Process and devices for the plasticized matter division and products obtained.

Process of transport of hydrocarbon mixtures in the form of suspensions.

Process and installation of congelation of liquid or semi-fluid products.

Method of preparation of magnesium chloride intended for the production of magnesium per molten salt electrolysis.

PROCEDURE AND DEVICE FOR THE PRODUCTION OF KOERNERN, AS HARNSTOFFKOERNERN

DEVICE FOR THE ATOMIZATION OF FUSIONS CINDER OF MEANS AIR

METALLIC POWDER MIXTURE FROM CEMENTED CARBIDE

EINRICHTUNG ZUR ERZEUGUNG EINES HEISSEN TREIBGASSTROMES

VERFAHREN ZUM TRANSPORT EINER KOHLENWASSERSTOFFMISCHUNG IN FORM EINER AUFSCHLAMMUNG

VERFAHREN ZUR HERSTELLUNG VON AMMONIUMSULFATGRANULATEN

EINRICHTUNG ZUM ZERSTÄUBEN UND ZERKLEINERN VON FLÜSSIGEN SCHMELZEN

MAKES SPHERICAL PARTICLE OF A MELT FROM PLASTIC

VERFAHREN ZUR HERSTELLUNG VON SPHAERISCHEN KERNBRENNSTOFFTEILCHEN

VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON FESTEN TEILCHEN

�BERKRITISCHE ATOMISING AND BLISTERS TROCHNEN FLUIDGEST�TZTE

PRODUCTION CELEBRATIONS OF A PIGMENT PREPARATION IN FORM OF GRANULATES OF MEANS SPRAY DRYING

PROCEDURE FOR THE PRILLIEREN OF MELTED MATERIAL AND PRILLIERKOPF TO DURCHFUHRUNG THE PROCEDURE

DEVICE FOR THE PRODUCTION OF CELEBRATIONS KORNERN FROM MELTED MATERIAL

DEVICE FOR PREVENTING THE VERKRUSTENS OF DISCHARGE DEVICES OF PRILLTUERMEN

TORQUE TUBE RETORT TO WASTE PYROLYSIS

DEVICE FOR CATCHING AND DELIVERING IN A PRILLTURM FALLING DOWN PRILLGUT

PROCEDURE FOR THE PRODUCTION OF A MUD

DEVICE AND PROCEDURE FOR THE PRODUCTION OF FIRM PARTICLES

DEVICE FOR PREVENTING THE VERKRUSTENS OF DISCHARGE DEVICES OF PRILLTUERMEN

EINRICHTUNG ZUR ERZEUGUNG EINES HEISSEN TREIBGASSTROMES

Verfahren zum Granulieren von schmelzbaren Stoffen

The invention relates to a method for granulating meltable materials, spherical prills (2) being produced from the melted material (3). The melted material (3) is introduced into a spray system with a cup-shaped spray head (12) which rotates about a vertical axis while a spray cage (10) rotates about the longitudinal axis, and the drops are discharged in the radial direction through perforations in the casing of the spray cage (10). The drops fall between the casing of the spray cage (10) and the inner wall of a solidifying tower (11) in the direction of the bottom outlet of the solidifying tower (11). The prills (2) are transported through a gaseous coolant which flows through the solidifying tower (11) in the longitudinal direction. In the process, the outer surface of the prills (2) is cooled to a temperature less than or equal to the solidifying temperature. The rotational speed of the spray cage (10) and the flow speed of the gaseous coolant are limited at the top such that the trajectory ...

Verfahren zum Granulieren von schmelzbaren Stoffen

The invention relates to a method for granulating meltable materials, spherical prills (2) being produced from the melted material (3). The melted material (3) is introduced into a spray system with a cup-shaped spray head (12) which rotates about a vertical axis while a spray cage (10) rotates about the longitudinal axis, and the drops are discharged in the radial direction through perforations in the casing of the spray cage (10). The drops fall between the casing of the spray cage (10) and the inner wall of a solidifying tower (11) in the direction of the bottom outlet of the solidifying tower (11). The prills (2) are transported through a gaseous coolant which flows through the solidifying tower (11) in the longitudinal direction. In the process, the outer surface of the prills (2) is cooled to a temperature less than or equal to the solidifying temperature. The rotational speed of the spray cage (10) and the flow speed of the gaseous coolant are limited at the top such that the trajectory ...

Vorrichtung und Verfahren zum Nachrösten von Metalloxiden

Die Erfindung betrifft eine Vorrichtung zum Nachrösten von in einem Reaktor pyrohydrolytisch gewonnenem Metalloxid, wobei der Reaktor wenigstens einen Reaktorboden mit wenigstens einer Austragsöffnung für das Metalloxid umfasst, dadurch gekennzeichnet, dass unterhalb des Reaktorbodens und an der Reaktoraußenseite mit diesem verbunden, eine Nachröstvorrichtung in Form eines Etagenofens ( 1) vorgesehen ist, wobei die Nachröstvorrichtung ferner mit Leitungen zum Zuführen eines gasförmigen Wärmeträgers ausgestattet ist und wenigstens zwei Böden (2) umfasst, welche Böden (2) wenigstens eine Austragsöffnung ( 3) und eine Fördervorrichtung pro Boden aufweisen.

PROCEDURE AND DEVICE FOR GRANULATING AND CUTTING UP LIQUID CINDERS

PROCEDURE FOR MANUFACTURING CONSOLIDATING, SUPERFICIAL OF STICKY GRANULATES AS WELL AS FOR THE EXECUTION OF THE PROCEDURE SUITABLE DEVICE

PROCEDURE AND DEVICE FOR THE SPRAYING OF A MIXING INTO A PASTE WITH.

DEVICE FOR SUPPLYING AND SPRAYING OF AETZNATRONSCHMELZE.

MECHANISM FOR SPUTTERING AND CUTTING UP LIQUID MELTS

PROCEDURE AND DEVICE FOR THE PRODUCTION OF CELEBRATIONS PARTICLES

IN WATER REDISPERGIERBARE GRANULATES WITH LIQUID ACTIVE MATERIAL

DEVICE AND PROCEDURE FOR THE PRODUCTION OF POWDERS AND OTHER GRANULATFOERMIGEN MATERIALS.

PROCEDURE FOR THE PRODUCTION OF PARTIKLEN USING A SUPERCRITICAL LIQUID

PROCEDURE AND DEVICE FOR THE PRODUCTION OF PARTICLES

Device for the production of spherical particles

METHOD FOR THE COVERING OF PARTICLES IN A SPRAY DRYING PLANT

Procedure for the production of dry pigment granulates

Procedure and device for dividing a material, in particular glass

PROCEDURE AND DEVICE FOR THE PRODUCTION OF GRANULATES FROM PRE-PRODUCTS OF THERMOPLASTIC POLYESTERS AND COPOLYESTER

Procedures for the production of firm Alkalipolyphospaten from Alkaliphospat entahlteden thin solutions or suspensions

PROCEDURE FOR THE PRODUCTION OF PARTICLES

Spherical powder and its preparation

A spherical tungsten carbide powder is characterized by that the material has a microhardness higher than 3600 kgf/mm 2 , and that the powder has an apparent density from 9.80 to 11.56 g/cm 3 . A method for the manufacture of a powder comprises the steps: a) providing a chamber comprising a rotatable crucible, b) adding material into said rotatable crucible, c) melting the material using a plasma arc discharge, d) rotating the crucible to atomize the molten material to form liquid droplets, with subsequent cooling of the droplets to obtain a powder, wherein the material added into said rotatable crucible is heated to a temperature above 40% of the melting temperature of the material before it enters the crucible. It is possible to reduce the current required for melting the stock. Heat losses are decreased, and the spherical powder obtained during atomization becomes more homogeneous in its composition and structure. The cost is reduced.

Polymer pelletization via melt fracture

Polymer pellets are formed using air to influence the separation of polymer from a polymer melt. In accordance with one or more embodiments, a polymer material is extruded through a nozzle to form a polymer melt extending from the nozzle. A non-uniform thickness is generated in the polymer melt using a gas or gasses to apply a drag force to the polymer melt. This drag force reduces a thickness of a portion of the polymer melt adjacent the nozzle, and the polymer melt is fractured into discrete droplets at the reduced thickness. The discrete droplets are then solidified to form pellets.

Sweet particulate fat-containing powder, its preparation and its use

The present invention relates to powders comprising, based on dry weight: (a) 25-75 wt. % carbohydrates, including at least 50% sucrose by weight of said carbohydrates; (b) 10-70 wt. % fat; and (c) 0.4-20 wt % protein; wherein the powder comprise an amorphous matrix of fat, protein and carbohydrates as well as sucrose crystallites embedded therein; and wherein at least 40% of the sucrose is present in crystalline form. Processes of preparing the powders are also provided, comprising: (a) providing a dispersion comprising fat, carbohydrate, protein and water, and having a dry solids content of 50-75 wt. %; (b) providing a finely divided particulate sucrose; and (c) spray drying the dispersion into a spray drier whilst continuously introducing the finely divided particulate sucrose into the spray drier in an amount of at least between 40 and 80 wt. % based on the total weight of carbohydrates in the final spray dried product.

Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

Spray drier assembly for automated spray drying

A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device adapted to couple with a spray drier assembly. The assembly may include an enclosure mounted to a frame. The assembly may receive a flow of drying gas which is directed by the enclosure shape towards a spray drying head mounted within the enclosure to the frame. Flows of a liquid sample may be further received by the head, which aerosolizes the liquid sample. Aerosolized liquid sample and drying air may be mixed within a drying chamber of the enclosure to produce dried sample and humid air. The dried sample and humid air may also be separated in a collection chamber of the enclosure, with the humid air exhausted from the enclosure.

Preparation of nanoparticles by flash evaporation

The invention relates to the field of preparing nanoparticles. In particular, the invention provides a method for preparing organic or inorganic nanoparticles by instantaneous evaporation or flash evaporation, e.g. for the manufacture of nanoparticles of fertilizers, pharmaceutical or phytopharmaceutical active ingredients, or insensitive energy materials.

Taxane Particles and Their Use

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

METHOD OF CONTROLLING THE SPRAY DROPLET SIZE OF A SPRAY NOZZLE APPARATUS FOR SPRAY-DRYING APPLICATIONS, SPRAY DRYING APPARATUS AND NOZZLE THEREFORE

A method of controlling the spray droplet size of a spray nozzle apparatus, in particular for the manufacturing of food powders, delivered to the spray nozzle comprises the following steps: a) providing a paste of a product to be sprayed by a spray nozzle; b) continuously determining the shear viscosity (η) of the product paste delivered to the spray nozzle; c) determining the mass flow rate (Qm) of the product paste delivered to the spray nozzle; d) determining the static pressure (P) of the product paste delivered to the spray nozzle; e) determining the density (p) of the product paste delivered to the spray nozzle; f) delivering the data obtained in steps b) to e) to a control device comprising a computer and a memory; g) calculating control data for adjusting the spray nozzle on the basis of the data obtained in steps b) to e) and on nozzle geometry parameters stored in the memory; h) sending the control data as control signals to a control means of the spray nozzle and adjusting the spray nozzle accordingly. 1. A method of controlling the spray droplet size of a spray nozzle apparatus delivered to the spray nozzle , the method comprises the following steps of:a) providing a paste of a product to be sprayed by a spray nozzle;b) continuously determining the shear viscosity of the product paste delivered to the spray nozzle;c) determining the mass flow rate of the product paste delivered to the spray nozzle;d) determining the static pressure of the product paste delivered to the spray nozzle;e) determining the density of the product paste delivered to the spray nozzle;f) delivering the data obtained in steps b) to e) to a control device comprising a computer and a memory;g) calculating control data for adjusting the spray nozzle on the basis of the data obtained in steps b) to e) and on nozzle geometry parameters stored in the memory; andh) sending the control data as control signals to a control means of the spray nozzle and adjusting the spray nozzle accordingly ...

PROCESS FOR THE PREPARATION OF POLYOLEFIN PARTICLES

The present invention relates to a process for producing polyolefin particles from a polyolefin composition, comprising the steps of: a) providing a melted composition of a polyolefin and b) providing particles from the melted composition by: b1) mixing a first flow of a supercritical fluid in the melted composition in a pressure vessel to obtain a solution saturated with the supercritical fluid and b2) passing the solution from the pressure vessel through a throttling device to a spraying tower to expand the solution to obtain the polyolefin particles in the spraying tower, wherein a second flow of a supercritical fluid is injected in the throttling device, wherein the supercritical fluid is a supercritical fluid of a substance selected from the group consisting of CO, NH3, HO, NO, CH, ethane, propane, propylene, n-butane, i-butane, n-pentane, benzene, methanol, ethanol, isopropanol, isobutanol, chlorotrifluoromethane, monofluoromethane, 1,1,1,2-Tetrafluoroethane, toluene, pyridine, cyclohexane, cyclohexanol, o-xylene, dimethyl ether and SFand combinations thereof. 1. A process for producing polyolefin particles from a polyolefin composition , comprising the steps of:a) providing a melted composition of a polyolefin and b1) mixing a first flow of a supercritical fluid in the melted composition in a pressure vessel to obtain a solution saturated with the supercritical fluid and', 'b2) passing the solution from the pressure vessel through a throttling device to a spraying tower to expand the solution to obtain the polyolefin particles in the spraying tower,, 'b) providing particles from the melted composition bywherein a second flow of a supercritical fluid is injected in the throttling device,{'sub': 2', '3', '2', '2', '4', '6, 'wherein the supercritical fluid is a supercritical fluid of a substance selected from the group consisting of CO, NH, HO, NO, CH, ethane, propane, propylene, n-butane, i-butane, n-pentane, benzene, methanol, ethanol, isopropanol, isobutanol, ...

SPRAY-DRIED SOLID-IN-OIL-IN-WATER DISPERSIONS FOR INHALATION OF ACTIVE PHARMACEUTICAL INGREDIENTS

Embodiments of the invention relate to particulate agents and compositions comprising particulate agents for inhalation, and methods for preparing such particulate agents and compositions for inhalation, as well as therapeutic methods. Embodiments of the method comprise preparing an emulsion by combining an oil phase dispersion of hydrophobic seed particles and an aqueous dispersion comprising an emulsifier and an emulsion stabilizer and preparing a feedstock comprising encapsulated particles by homogenizing the emulsion, and forming a plurality of coated particles by spray drying the feedstock, wherein resulting particles comprises a porous shell disposed on or over a core and the core comprises at least one hydrophobic seed particle. 1. A method for forming particulate agents , comprising:dispersing hydrophobic seed particles within an oil medium to make an oil phase dispersion;making an aqueous dispersion comprising an emulsifier and an emulsion stabilizer;combining the oil phase dispersion and aqueous dispersion to make an emulsion;homogenizing the emulsion to result in a feedstock comprising encapsulated hydrophobic seed particles, oil medium, emulsifier, and emulsion stabilizer; anddrying the feedstock to form a plurality of coated particles, wherein each coated particle comprises a porous shell disposed over a core, wherein the core comprises at least one of the hydrophobic seed particles.2. The method of claim 1 , wherein the step of drying of the feedstock further comprises:atomizing the feedstock to generate liquid droplets comprising a discrete phase of encapsulated particles within a continuous aqueous phase;drying the liquid droplets at a first temperature within a drying chamber; andseparating the coated particles from the water vapor.3. The method of claim 1 , wherein the hydrophobic seed particles comprise a beta-adrenoceptor agonist claim 1 , a sodium channel blocker claim 1 , an anti-muscarinic claim 1 , a mucocillary clearance agent claim 1 , and ...

PROCESS AND FACILITY FOR PRODUCING A POWDERED POROUS PRODUCT

Disclosed is a process in which a viscous initial product having both a temperature of between 5° C. and 70° C. and a viscosity greater than 100 mPa·s is provided, —by way of a pump provided upstream of at least one aerator, the viscous initial product is transferred as it is to the at least one aerator in which the viscous initial product is mixed with a gas, injected into the aerator, so as to obtain a liquid foam continuously exiting the aerator, and—the liquid foam continuously exiting the at least one aerator is continuously pushed into the inlet of a treatment device which continuously divides and then dries this liquid foam so as to obtain a powdered porous product which has a solids content greater than 90%. 114-. (canceled)15. A method for producing a powdery porous product , wherein:a viscous initial product having both a temperature comprised between 5° C. and 70° C. and a viscosity greater than 100 mPa·s is provided,by means of a pump provided upstream from at least one aerator, the viscous initial product is transferred as such as far as said at least one aerator in which the viscous initial product is mixed with a gas, injected into the aerator, for obtaining a liquid foam continuously leaving the aerator, andthe liquid foam continuously leaving said at least one aerator is continuously pushed into an inlet of a treatment device which, continuously divides and then dries this liquid foam in order to obtain a powdery porous product which has a dry material level greater than 90%.16. The method according to claim 15 , wherein the specific gravity of the liquid foam leaving said at least one aerator is comprised between 25 and 80% of the specific gravity of the viscous initial liquid.17. The method according to claim 15 , wherein the liquid foam is continuously pushed from the outlet of said at least one aerator to the inlet of the treatment device either exclusively under the effect of the pressure prevailing in said at least one aerator claim 15 , or ...

Spray Drying Process for Production of Powders with Enhanced Properties

An improved spray drying method for production of amorphous solid dispersions with enhanced bulk density and material attributes comprising the introduction of at least one additional stream in at least one of multiple locations in a spray dryer without interfering with the spray region. 1. A spray drying process , which process comprises the steps of:a. providing a feed mixture comprising: one or more active pharmaceutical ingredients (APIs), one or more excipients, or mixtures thereof; and a solvent system comprising at least one solvent;b. feeding said feed mixture to a spray drying apparatus comprising a spray dryer chamber;c. atomizing said feed mixture into droplets using an atomization nozzle;d. drying said droplets with a drying gas to produce particles of said one or more APIs; one or more excipients, or mixtures thereofe. feeding one or more secondary gas streams to the spray drying apparatus in at least one of multiple locations in the spray drying apparatus;f. recovering said particles from the spray dryer chamber.2. The spray drying process according to claim 1 , wherein the feed mixture comprises one or more active pharmaceutical ingredients and one or more excipients.3. The spray drying process according to claim 1 , wherein the process comprises producing amorphous solid dispersions of the one or more APIs claim 1 , the one or more excipients claim 1 , or the one or more APIs and one or more excipients.4. The spray drying process according to claim 1 , wherein the one or more excipients comprise one or more polymers.5. The spray drying process according to claim 1 , wherein the one or more excipients comprise N-vinyl lactam claim 1 , copolymer of N-vinyl lactam claim 1 , cellulose ester claim 1 , cellulose ether claim 1 , polyalkylene oxide claim 1 , polyacrylate claim 1 , polymethacrylate claim 1 , polyacrylamide claim 1 , polyvinyl alcohol claim 1 , vinyl acetate polymer claim 1 , oligosaccharide claim 1 , polysaccharide claim 1 , homopolymer of N- ...

Multi-Nozzle Spray Dryer, Method for Scale-Up of Spray Dried Inhalation Powders, Multi-Nozzle Apparatus and Use of Multiple Nozzles in a Spray Dryer

This present invention provides a spray dryer for use in preparing particles for inhalation, the spray dryer comprising a multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders and with a drying gas flow rate greater than about 80 kg/h. Also provided is a method for scaling-up a spray drying process for preparing particles for inhalation from a smaller scale spray dryer to a larger scale spray dryer, relative in size to each other, the method comprising the use in the larger scale spray dryer of a multi-nozzle apparatus comprising single nozzles suitable for use in preparing inhalation powders, wherein the number of nozzles in the larger spray dryer is determined by the ratio of the drying gas flow rate of the larger scale spray dryer to the drying gas flow rate of the smaller scale spray dryer. Also provided is a multi-nozzle apparatus produced from the method of the present invention, the multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders. Also provided is the use of multiple single nozzles suitable for use in preparing inhalation powders in a spray dryer with a drying gas flow rate greater than about 80 kg/h. The nozzles used in the present invention preferably prepare particles with a mean particle size less than about 5 microns. 1. A method for scaling-up a spray drying process for preparing particles for inhalation from a smaller scale spray dryer to a larger scale spray dryer , relative in size to each other , said method comprising the use in the larger scale spray dryer of a multi-nozzle apparatus comprising single nozzles suitable for use in preparing inhalation powders , wherein the smaller scale spray dryer comprises a number m of nozzles and the larger scale spray dryer comprises a number n of nozzles , and wherein n is determined by the ratio of the drying gas flow rate of the larger scale spray dryer to the drying gas flow rate of the smaller ...

Improved Spray Drying Process for Production of Powders with Enhanced Properties

An improved spray drying method for production of amorphous solid dispersions with enhanced bulk density and material attributes comprising the introduction of at least one additional stream in at least one of multiple locations in a spray dryer without interfering with the spray region. 1. A spray drying apparatus comprising at least one secondary gas stream inlet in at least one of multiple locations in the spray drying apparatus , wherein the spray drying apparatus comprises a spray dryer chamber comprising an atomization nozzle and a drying gas inlet; and a means for recovering spray dried particles from the spray dryer chamber comprising a cyclone , a filter bag , a container , or any combination thereof; wherein at least one of the at least one secondary gas stream inlets is in at least one of the following locations:{'b': '30', 'i) in a connection between the drying chamber and the means for recovering spray dried particles from the spray dryer chamber (location );'}{'b': '32', 'ii) in a connection between a means for recovering spray dried particles from the spray dried chamber such as a cyclone, and a container (location ); and'}{'b': '34', 'iii) in a solids container (location ).'}2. The spray drying apparatus according to claim 1 , wherein the apparatus is for producing solid dispersions with increased bulk density relative to a corresponding spray drying apparatus that does not comprise secondary gas stream inlets.3. The spray drying apparatus according to claim 1 , wherein the means for recovering spray dried particles from the spray dryer chamber comprises a cyclone connected between the spray dryer chamber and a container.4. The spray drying apparatus according to claim 1 , wherein the spray dryer chamber comprises a cylindrical top section and a conical bottom section.5. The spray drying apparatus according to claim 1 , wherein the container for recovering particles is connected to the outlet of the conical lower section.6. The spray drying apparatus ...

BITUMEN SOLIDIFICATION AND PRILLING

Methods, processes, and apparatuses for preparing and transporting bitumen. Bitumen may be prilled such that a bitumen product comprising a prill core and a non-stick coating is produced. The non-stick coating may comprise asphaltenes and the prill core may comprise bitumen, deasphalted oil, or both bitumen and deasphalted oil. The resultant non-stick coated prills have reduced adhesion to transportation vessels and other non-stick coated prills at a temperature below an adhesion temperature, facilitating transport. 1. An apparatus for preparing a non-stick coated prill , the apparatus comprising:a prilling vessel having an upper section and a lower section;a first inlet for inputting bitumen, deasphalted oil, or a combination thereof, in the upper section of the prilling vessel and forming a prill core;a second inlet for inputting a carrier gas to the lower section of the prilling vessel for cooling the prill core;a first outlet for discharging the carrier gas from the upper section of the prilling vessel;a third inlet for inputting a non-stick coating material for coating the prill core; anda second outlet for outputting the non-stick coated prill.2. The apparatus according to claim 1 , wherein the first inlet comprises a nozzle or prilling head.3. The apparatus according to claim 1 , wherein the apparatus is configured to cool the prill core from about 180° C. at the upper section of the prilling vessel to about 30° C. at the lower section of the prilling vessel.41. The apparatus according to claim 1 , wherein the non-stick coating material comprises asphaltenes as a powder claim 1 , as a liquid which subsequently solidifies claim 1 , as a solvent-diluted asphaltenes solution which subsequently solidifies claim 1 , or a combination thereof.5. The apparatus according to claim 4 , wherein the non-stick coating material comprises asphaltenes as a toluene-diluted asphaltenes. Any and all applications for which a foreign or domestic priority claim is identified in the ...

High dielectric compositions for particle formation and methods of forming particles using same

A high dielectric composition for particle formation that includes a high dielectric solvent, and a high dielectric polymer dissolved into the high dielectric solvent. A method of forming particles including dissolving a high dielectric polymer in a high dielectric solvent to form a high dielectric composition, and dielectrophoretically spinning the high dielectric composition in an electrostatic field to form particles.

MODULAR SPRAY DRYER SYSTEM

A spray drying system for drying liquid into powder including a plurality of processing towers each including an elongated drying chamber, a spray nozzle assembly at an upper end of the drying chamber and a powder collection chamber at a lower end of the drying chamber. The powder collection chamber of each processing tower being configured to discharge power to a common conveyor system. 1. A spray drying system for drying liquid into powder comprising: an elongated body supported in an upright position;', 'a closure arrangement at opposite upper and lower ends of the elongated body for forming a drying chamber within said elongated body;', 'a liner disposed within said elongated body in spaced relation to an inner wall surface of the elongated body for defining an internal drying zone with said elongated body;', 'one of said closure arrangements including a drying gas inlet for coupling to a drying gas source and for directing drying gas into said drying zone;', 'an electrostatic spray nozzle assembly supported in one of the closure arrangements;', 'said electrostatic spray nozzle assembly including a nozzle body having a liquid inlet for coupling to a supply of liquid, a discharge spray tip assembly at a downstream end for directing liquid to be dried into said drying zone and an electrode for coupling to an electrical source for electrically charging liquid passing through said spray nozzle assembly into said drying zone; and', 'said lower end closure arrangement including a powder collection chamber for collecting powder dried in said drying zone; and, 'a plurality of processing towers, each processing tower comprisinga common conveyor system wherein said powder collection chamber of each processing tower is configured to discharge powder to the common conveyor system.2. The spray drying system of wherein a plurality of said electrostatic nozzle assemblies are supported in the closure member at the upper end of the elongated body of each processing tower.3. The ...

METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS

Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers. 2. The process of wherein said droplets have an average diameter of at least 50 μm and a Dof at least 10 μm.3. The process of wherein at least 80 vol % of said particulates have diameters of greater than 10 μm.4. The process of wherein at least 90 vol % of said particulates have diameters of greater than 10 μm.5. The process of wherein said particles have an average diameter of at least 40 μm.6. The process of wherein said particles have an average diameter of at least 50 μm.7. The process of wherein said spray-drying apparatus further comprises a gas disperser for dispersing said gas into said drying chamber.8. The process of wherein said drying gas is dispersed into said drying chamber such that the primary axis of flow of said drying gas is parallel to the axis of said atomizing means. The use of spray-drying to produce powders from fluid feed stocks is well known, with applications ranging from powdered milk to bulk chemicals and pharmaceuticals. See U.S. Pat. No. 4,187,617 and Mujumbar et al., 91, pages 56-73 (1991). The use of spray-drying to form solid amorphous dispersions of drugs and concentration-enhancing polymers is also known. See commonly owned European Patent Applications Nos. 0 901 786, 1 027 886, 1 027 887, 1 027 888, and commonly-owned PCT Applications Nos. WO 00/168092 and WO 00/168055. And the use of a perforated plate as an air disperser for a spray-dryer using a nozzle atomizer is also known. See Masters, , pages 263-268 (4ed 1985).A typical spray-drying apparatus comprises a drying chamber, atomizing means for atomizing a solvent-containing feed into the drying chamber, a source of heated drying gas that flows into the drying ...

PREPARATION OF A QUARTZ GLASS BODY IN A STANDING SINTER CRUCIBLE

The invention relates to a process for the preparation of a quartz glass body comprising the process steps i.) Providing a silicon dioxide granulate, ii.) Making a glass melt out of silicon dioxide granulate in an oven and iii.) Making a quartz glass body out of at least part of the glass melt, wherein the oven comprises a standing sinter crucible. The invention further relates to a quartz glass body which is obtainable by this process. The invention further relates to a light guide, an illuminant and a formed body, which are each obtainable by further processing of the quartz glass body. 118-. (canceled)19. A process for the preparation of a quartz glass body comprising: [{'sup': '2', 'a BET surface area in a range from 20 to 50 m/g; and'}, 'a mean particle size in a range from 50 to 500 μm;, 'providing a silicon dioxide granulate, wherein the silicon dioxide granulate was prepared from pyrogenic silicon dioxide, wherein the silicon dioxide granulate comprisesmaking a glass melt out of the silicon dioxide granulate in an oven; andmaking a quartz glass body out of the glass melt;wherein the oven comprises a standing sinter crucible.20. The process according to claim 19 , wherein the sinter crucible is made of a sinter material claim 19 , which comprise a sinter metal selected from the group consisting of molybdenum claim 19 , tungsten and a combination thereof.21. The process according to claim 20 , wherein the sinter metal of the sinter crucible has a density of 85% or more of the theoretical density of the sinter metal.22. The process according to claim 19 , wherein the BET surface area is not reduced to less than 5 m/g before making the glass melt out of the silicon dioxide granulate in the oven.23. The process according to claim 19 , wherein the standing sinter crucible comprises at least one of:an area formed as a standing surface;at least two sealed on rings as side parts;a nozzle;a mandrel;at least one gas inlet;at least one gas outlet; anda lid.24. The ...

AMORPHOUS CARBON COATING OF CARBONACEOUS PARTICLES FROM DISPERSIONS INCLUDING AMPHIPHILIC ORGANIC COMPOUNDS

The present disclosure relates to a process for preparing surface-modified carbonaceous particles, wherein said carbonaceous particles are coated with a surface layer of amorphous carbon by dispersing carbonaceous material with an amphiphilic compound, spray drying of the dispersion and subsequent calcination of the dried material. The disclosure also pertains to surface-modified carbonaceous particles coated with amorphous carbon, which can for example be obtained by the process of the invention. The present disclosure further relates to the use of the surface-modified carbonaceous particles in a variety of technical applications, such as its use as an active material for negative electrodes of lithium ion batteries. The present disclosure also relates to a carbon brush or a polymer composite material, and generally compositions comprising said surface-modified carbonaceous particles, optionally together with other carbonaceous or non-carbonaceous materials. 1. A process for preparing surface-modified carbonaceous particles wherein said carbonaceous particles are coated with a surface layer of amorphous carbon , comprisinga. dispersing carbonaceous particles together with an amphiphilic organic compound,b. spray-drying the dispersion, andc. effecting carbonization of the spray-dried particles comprising the amphiphilic organic compound on the surface of said particles.2. The process according to claim 1 , wherein the carbonaceous particles to be surface-modified are selected from graphitic particles including natural or synthetic graphite claim 1 , exfoliated graphite claim 1 , graphene claim 1 , few-layer graphene claim 1 , graphite fibers claim 1 , nanographite claim 1 , or non-graphitic carbon claim 1 , including carbon black claim 1 , petroleum- or coal-based coke claim 1 , glassy carbon claim 1 , nanotubes claim 1 , fullerenes claim 1 , or combinations thereof claim 1 , optionally together with other non-carbonaceous particles (e.g. claim 1 , metallic ...

Thermoplastic Polyurethane Particles And Manufacturing Method Therefor

The present invention provides thermoplastic polyurethane particles, which are formed in a continuous matrix phase from a thermoplastic polyurethane resin and have a particle diameter of 200-500 μm. In a differential scanning calorimetry (DSC) curve of the thermoplastic polyurethane particles, derived from the analysis of a temperature rise of 10° C./min by DSC, a peak of the cold crystallization temperature (T cc ) is shown at a temperature between the glass transition temperature (T g ) and the melting point (T m ). The thermoplastic polyurethane particles have a compression degree of 10-20%.

Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)]

Embodiments of a spray-drying process for producing low aspect ratio particles of poly[(methyl methacrylate)-co-(methacrylic acid)] (PMMAMA) are disclosed. In some examples, at least 95% of PMMAMA-containing particles made by the process have an aspect ratio <10. The particles may further include an active ingredient and/or an excipient.

DRY POWDER FORMATION USING A VARIABLY CONSTRAINED, DIVIDED PATHWAY FOR MIXING FLUID STREAMS

Methods of making a dry powder, comprise (a) delivering a liquid solution or suspension and a second, immiscible fluid to a flow path, (b) transporting the liquid solution or suspension and the immiscible fluid along the flow path, wherein the flow path includes two or more flow passages of different diameters, at least one flow divider which divides and diverts the flowing mixture into at least two separate passages, wherein the separate passages subsequently intersect to combine their respective flows into a single flowing stream, (c) rapidly reducing the pressure of the single flowing stream, whereby droplets are formed, and (d) passing the droplets through a flow of inert drying gas to form a dry powder. A nebulizing nozzle includes an inlet, a flow path as described, and a restrictor nozzle outlet. 1. A method of making a dry powder , comprising (a) delivering a liquid solution or suspension and an immiscible supercritical or near critical fluid to a flow path , (b) transporting a mixture of the liquid solution or suspension and the immiscible fluid along the flow path , wherein the flow path along which the mixture is transported includes two flow passages of different diameters , at least one flow divider which divides and diverts the flowing mixture into two separate passages , wherein the separate passages subsequently intersect to combine their respective flows into a single flowing stream , (c) rapidly reducing the pressure of the single flowing stream by passing the stream through a restrictor nozzle , whereby droplets are formed , and (d) passing the droplets through a flow of inert drying gas to form a dry powder.2. The method of claim 1 , wherein the flow path includes a first passage having a first diameter claim 1 , followed by a second passage having a second diameter larger than the first diameter claim 1 , followed by a third passage having a third diameter smaller than the second diameter claim 1 , followed by the flow divider which divides and ...

WET GRANULATED CELL CULTURE MEDIUM AND PREPARATION METHOD THEREFOR

Disclosed is a wet granulated cell culture medium and a preparation method therefor and, more specifically, to a wet granulated cell culture medium which supports the growth of mammalian cells and/or insect cells and/or plant cells and bacteria, and a preparation method therefor. 1providing a cell culture medium;dissolving the cell culture medium in purified water to produce an aqueous cell culture medium solution, wherein the aqueous cell culture medium solution consists of 0.5 to 3 parts by weight of purified water with respect to 1 part by weight of cell culture medium;feeding the aqueous cell culture medium solution to a bottom spray with a pump of a fluid bed, the fluid bed having a chamber in which the bottom spray is located at a bottom without a cylindrical partition surrounding the bottom spray, wherein the pump feeds the aqueous cell culture medium solution into the bottom spray at a speed between 180 ml/min and 500 ml/min;spraying the aqueous cell culture medium solution into the chamber of the fluid bed via the bottom spray without adding separate seed or coagulant, wherein the aqueous cell culture medium solution sprayed via the bottom spray is formed into droplets;{'sup': 3', '3, 'drawing out hot air in the chamber via a blower of the fluid bed at a volume of 500 m/hour to 6,000 m/hour, a temperature of the hot air ranging 60° C. to 110° C., wherein the droplets of the aqueous cell culture medium are formed into the fine particles due to absence of the cylindrical partition surrounding the bottom spray;'}in the same chamber of the fluid bed, repeating the spraying step via the bottom spray to the fine particles to coat a surface thereof so that the fine particles are formed into spherical granules, wherein surface tension generated by repeating the spraying step forms the spherical granules;drying the spherical granules by the hot air drawn out by the blower without the steps of feeding and spraying; andcollecting the spherical granules from the ...

METHOD FOR PRODUCING PULVERULENT SOLIDS FROM ALKALI SALTS OF SILANOLS

Pulverulent alkali metal alkyl siliconates having lesser hydroscopicity and improved hydrophobicity in construction materials are produced by spray drying an aqueous solution of an alkali metal alkylsiliconate having a defined range of alkali metal content, a low alcohol content, and a low chlorine content. 17.-. (canceled)9. The process of claim 8 , wherein the basic alkali metal salts are selected from the group consisting of alkali metal hydroxides claim 8 , alkali metal silicates claim 8 , alkali metal organosiliconates and mixtures thereof.10. The process of claim 8 , wherein water is removed in an amount so as to provide a solids content claim 8 , determined at 160° C. claim 8 , of at least 96% by weight based on the total weight of the pulverulent solid.11. The process of claim 8 , wherein the alcohol content of the pulverulent solid is not more than 0.05% by weight based on the total weight of the pulverulent solid.12. A pulverulent solid prepared by the process of claim 8 , having an alcohol content of not more than 0.01% by weight claim 8 , based on the total weight of the pulverulent solid.13. A building material mixture comprising at least one pulverulent solid of .14. A component or molding produced from a building material mixture of . This application is the U.S. National Phase of PCT Appln. No. PCT/EP2016/053603 filed Feb. 19, 2016, which claims priority to German Application No. 10 2015 204 263.4 filed Mar. 10, 2015, the disclosures of which are incorporated in their entirety by reference herein.The invention relates to a process for producing pulverulent solids comprising alkali metal organosiliconates for hydrophobicizing building materials.The alkali metal organosiliconates are also referred to as alkali metal salts of organosilicic acids. Alkali metal organosiliconates such as potassium, methyl siliconate have been used for decades for hydrophobization, in particular for mineral building materials. Owing to their good solubility in water, they ...

PARTICULATE POLY(LACTIC-CO-GLYCOLIC) ACID, METHOD FOR MANUFACTURING PARTICULATE POLY(LACTIC-CO-GLYCOLIC) ACID, AND PARTICULATE POLY(LACTIC-CO-GLYCOLIC) ACID MANUFACTURING APPARATUS

A particulate poly(lactic-co-glycolic) acid (PLGA) is provided. The particulate PLGA comprises a poly(lactic-co-glycolic) acid (PLGA), and has an average volume-based particle diameter of 80 nm or less and a relative span factor (R.S.F.) satisfying the following formula (1):

ELECTROSTATIC SPRAY DRYER APPARATUS AND METHOD

An electrostatic spray drying system comprising an electrostatic spray nozzle for directing electrically charged liquid into a drying chamber, a drying gas inlet from which drying gas is simultaneously directed, and a conical powder direction plenum for receiving drying gas and entrained dried powder for direction to a filter containing powder separation plenum via a connecting conduit. The powder direction plenum and connecting conduit each have a surrounding water jacket heat exchanger through which cooling water is directed for cooling the drying gas and powder below damaging temperatures prior to entry into the powder separation plenum. The powder separation plenum has a return line for redirecting separated drying gas to the drying chamber through a condenser, blower, and heater for reuse in the system, with condensed water being selectively redirected to the inlet of the powder direction plenum heat exchanger and/or to the cooling water supply.

STIMULI-RESPONSIVE COMPOSITE PARTICLES AND MANUFACTURING METHOD THEREOF

Provided are stimuli-responsive composite particles which contain microcapsules containing an electron-donating dye precursor and particles of an electron-accepting compound causing the electron-donating dye precursor to develop color, in which the microcapsules are attached to at least a portion of the surface of each of the particles of the electron-accepting compound. Also provided is a manufacturing method of the stimuli-responsive composite particle. 1. Stimuli-responsive composite particles comprising:microcapsules containing an electron-donating dye precursor encapsulated therein; andparticles of an electron-accepting compound causing the electron-donating dye precursor to develop color,wherein the microcapsules are attached to at least a portion of the surface of each of the particles of the electron-accepting compound.2. The stimuli-responsive composite particles according to that are used for any one of pressure measurement or heat measurement.3. The stimuli-responsive composite particles according to claim 1 ,wherein the electron-accepting compound is at least one kind of compound selected from the group consisting of activated clay, acid clay, kaolin, a phenol-based compound, a salicylic acid-based compound, and a hydroxybenzoic acid ester.4. The stimuli-responsive composite particles according to claim 1 ,wherein the electron-accepting compound is at least one kind of compound selected from the group consisting of activated clay, a bisphenol-based compound, and a salicylic acid-based compound.5. The stimuli-responsive composite particles according to claim 1 ,wherein the electron-accepting compound is activated clay and used for pressure measurement.7. The stimuli-responsive composite particles according to claim 1 ,wherein a ratio of a mass of the electron-donating dye precursor to a mass of the particles of the electron-accepting compound is 0.02 to 20.8. The stimuli-responsive composite particles according to claim 5 ,wherein a ratio of a mass of the ...

MECHANICAL SYSTEM THAT FLUIDIZES, MIXES, COATS, DRIES, COMBINES, CHEMICALLY REACTS, AND SEGREGATES MATERIALS

The present application is directed towards systems for adding components to materials being fluidized in a vibratory mixer by use of atomizers or sprayers. A mechanical system can fluidizes, mix, coat, dry, combine, or segregate materials. The system may comprise a vibratory mixer, mixing vessel containing a first material and a sprayer to introduce a second material. The vibratory mixer may generate a fluidized bed of a first material and the sprayer, coupled to the mixing vessel, may introduce a second material onto the fluidized bed to mix the materials in a uniform and even fashion. 1. A method for mixing a plurality of materials , the method comprising:generating a fluidized bed in a mixing vessel by oscillating, using a vibratory mixer, an entirety of the mixing vessel in a substantially linear direction perpendicular to a top surface of the fluidized bed, the fluidized bed comprising a first material;introducing a second material by a sprayer including at least one spray nozzle into the mixing vessel onto the fluidized bed; andcontrolling a pressure within the mixing vessel by a pressure control mechanism.2. The method of claim 1 , wherein the mixing vessel is sealed to maintain a pressure therein.3. The method of claim 1 , wherein controlling the pressure within the mixing vessel includes using a vent to allow air into or out of the mixing vessel.4. The method of claim 1 , wherein controlling the pressure within the mixing vessel includes operating a vacuum source coupled to a vacuum line coupled to the mixing vessel to create a negative pressure therein.5. The method of claim 1 , wherein controlling the pressure within the mixing vessel includes operating a pressure relief valve to maintain the pressure at or above atmospheric pressure.6. The method of claim 1 , wherein the at least one spray nozzle is coupled directly to at least one of a top portion claim 1 , a side portion claim 1 , or a bottom portion of the mixing vessel.7. The method of claim 1 , ...

SOLID DOSAGE FORM OF RIVAROXABAN AND METHODS FOR MAKING THE SAME

The present invention discloses a pharmaceutical composition that includes rivaroxaban and one or more excipient in a solid dosage form and methods for making the same. Methods for making compositions of the present invention includes powderizing rivaroxaban by centrifugal wet granulation to form compositions suitable for solid oral dosage form. Pharmaceutical dosage forms produced by methods of the present invention are more homogenous, smoother, and have better rheological properties, better compressibility, and much easier to make. They are much lower in cost and also easier to produce at industrial scales. 1. A method for preparing a composition comprising rivaroxaban and one or more excipients , said comprising:forming an oral dosage form comprising micronized rivaroxaban using centrifugal wet granulation;wherein said dosage form is suitable as a solid oral pharmaceutical composition.2. The method of claim 1 , wherein said method is performed by a centrifugal granulator.3. The method of claim 2 , wherein said granulator comprises a rotary base claim 2 , an air ventilation and heating device claim 2 , and said rotary base rotates at a rate of about 0 to about 1000 rpm during operation.4. The method of claim 2 , wherein said granulator further comprises one or more atomizing nozzle.5. The method of claim 1 , wherein said 90% of resulting rivaroxaban has a diameter less than 50 micrometer.6. The method of claim 1 , wherein the excipient comprise at least one disintegrating agent.7. The method of claim 1 , wherein the excipient comprises at least one thinning agent.8. The method of claim 1 , wherein the excipient comprises the combination of:at least one thinning agent, and at least one disintegration agent;at least one thinning agent, and at least one adhesive agent; orat least one thinning agent, at least one disintegrating agent, or at least one adhesive agent.9. The method of claim 1 , wherein said solid oral pharmaceutical composition comprises crystalline ...

Spray Drier Assembly For Automated Spray Drying

A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device adapted to couple with a spray drier assembly. The assembly may include an enclosure mounted to a frame. The assembly may receive a flow of drying gas which is directed by the enclosure shape towards a spray drying head mounted within the enclosure to the frame. Flows of a liquid sample may be further received by the head, which aerosolizes the liquid sample. Aerosolized liquid sample and drying air may be mixed within a drying chamber of the enclosure to produce dried sample and humid air. The dried sample and humid air may also be separated in a collection chamber of the enclosure, with the humid air exhausted from the enclosure.

PROPPANT BEAD FORMING METHODS

The disclosure herein includes methods of preparing ceramic beads, useful as proppant materials, by mixing ceramic precursors, such as slag, fly ash, or aluminum dross, forming bead precursors from the mixture, and heating the bead precursors to drive a chemical reaction between the ceramic precursors to form the ceramic beads. The resultant ceramic beads may be generally spherical particles that are characterized by diameters of about 0.1 to 2 mm, a diametral strength of at least about 100 MPa, and a specific gravity of about 1.0 to 3.0. A coating process may optionally be used to increase a diametral strength of a proppant material. A sieving process may optionally be used to obtain a smaller range of sizes of proppant materials. 1. A method of preparing a plurality of ceramics bead comprising:mixing a plurality of ceramic precursors to form a mixture comprising particles of the ceramic precursors having sizes of about 30 μm to about 500 wherein the ceramic precursors include two or more of fly ash, slag, carbon black, pumice, and aluminum dross;forming a plurality of bead precursors each comprising the mixture, wherein the bead precursors each have cross-sectional dimensions of about 0.1 mm to about 2.5 mm; andheating the bead precursors to a temperature of greater than about 1200° C. to initiate a chemical reaction between the ceramic precursors, wherein the chemical reaction transforms the bead precursors into ceramic beads, wherein the ceramic beads are each characterized by one or more of a diameter of about 0.03 mm to about 2.0 mm, diametral strengths greater than about 100 MPa, and a specific gravity of about 1.0 to about 3.0.2. The method of claim 1 , wherein the mixture comprises one or more of:a suspension, an emulsion, or a slurry comprising the plurality of ceramic precursors suspended in a solvent;homogenized ceramic precursors; orground or milled ceramic precursors.3. The method of claim 1 , wherein the mixture comprises slag and fly ash claim 1 , ...

METHOD AND APPARATUS FOR MANUFACTURE OF DRY POWDERS

A method of production of a homogeneous powdered product from a starting product in a liquid state, the starting product having sugars as at least 60% of its total solids, the method comprising: in the absence of air: pressurizing the starting product to a pressure greater than 1 bar; injecting a gas into the starting product to form a mixture in which the starting product is substantially saturated by the gas; and degassing the mixture into a continuous stream of transport gas such that, on contact with the transport gas, water from the mixture evaporates to leave the homogeneous powdered product. 1. A method of production of a homogeneous powdered product from a starting product in a liquid state , the starting product having sugars as at least 60% of its total solids , the method comprising: pressurizing the starting product to a pressure greater than 1 bar;', 'injecting a gas into the starting product to form a mixture in which the starting product is substantially saturated by the gas; and, 'in the absence of airdegassing the mixture into a continuous stream of transport gas such that, on contact with the transport gas, water from the mixture evaporates to leave the homogeneous powdered product.2. The method of claim 1 , wherein the gas is carbon dioxide claim 1 , nitrous oxide claim 1 , nitrogen claim 1 , or a mixture of one or more of carbon dioxide claim 1 , nitrous oxide and nitrogen.3. The method of claim 2 , wherein the gas is carbon dioxide and wherein the mixture comprises carbon dioxide in a quantity in excess of 35 grams per 100 grams of water in the starting product.4. The method of any one of to claim 2 , wherein the carbon dioxide is present in a quantity sufficient to saturate the starting product so as to form a solution comprising carbonic acid and at least some of the starting product.5. The method of claim 2 , wherein the gas is nitrous oxide and wherein mixture comprises nitrous oxide in a quantity in excess of 50 ml per 100 ml of water in ...

A METHOD AND A SYSTEM FOR MONITORING SPRAY NOZZLES IN A SPRAY DRYING OR SPRAY COOLING CHAMBER

There is provided a method for monitoring deposit build-up on spray nozzles in a spray drying or spray cooling chamber. The method comprises feeding drying air or cooling air into the chamber, and feeding a feed material to be spray dried or spray cooled into the chamber through one or more spray nozzles, thereby obtaining one or more sprays of feed material in contact with drying or cooling air. A digital reference image is obtained, which reference image has an image area comprising a first area of interest covering at least part of a spray nozzle and/or part of a feed material spray corresponding to a spray nozzle. A number of process images are obtained and recorded, where the process images cover the same image area as the reference image, and at least part of the recorded process images are compared with the reference image, and a difference, if any, is detected for the first interest area between the reference image and the process images being compared to the reference image. A notification or error notification may be issued based on the detected differences. The notification may be issued when a predetermined minimum difference is detected for each of a predetermined number of recorded process images. The present invention also provides a system for monitoring spray nozzles in a spray drying or spray cooling chamber. 1. A method for monitoring deposit build-up on spray nozzles in a spray drying or spray cooling chamber , said method comprising:feeding drying air or cooling air into the chamber;feeding a feed material to be spray dried or spray cooled into the chamber through one or more spray nozzles, thereby obtaining one or more sprays of feed material in contact with drying or cooling air; andobtaining and recording images by use of one or more digital optical cameras, said images having an image area comprising a first area of interest covering at least part of a spray nozzle and/or part of a feed material spray corresponding to a spray nozzle;said ...

FORMATION AND CONTROL OF FLUIDIC SPECIES

This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like. 1. A microfluidic device for producing a plurality of droplets comprising:a first microfluidic channel for flowing a first liquid;a second microfluidic channel for flowing a second liquid, the second microfluidic channel meeting the first microfluidic channel at a junction; andelectrodes operably associated with the junction and configured to provide an electric field at the junction to generate droplets of the first ...

Process for preparing a polyamide, a nylon salt to be used therein and a process for making the salt

Processes for preparing a polyamide, a polyamide material obtained by such processes, a nylon salt to be used therein, and processes for making the nylon salt are disclosed. The processes for preparing the polyamide include a direct solid state polymerization process. The salt used herein is a granulate material, prepared by a process, comprising spraying an aqueous solution comprising a diamine and a dicarboxylic acid dissolved in an aqueous medium, or an aqueous slurry comprising a diammonium dicarboxylate salt dispersed in an aqueous medium directly obtained from such an aqueous solution, onto or in a fluidized bed of diammonium dicarboxylate salt particles, while evaporating the aqueous medium, thereby forming a granulate salt material.

Porous silicon composite cluster and carbon composite thereof, and electrode, lithium battery, field emission device, biosensor and semiconductor device each including the same

A porous silicon composite cluster comprising: a porous core comprising a porous silicon composite secondary particle, wherein the silicon composite secondary particle comprises an aggregate of two or more silicon composite primary particles, and the silicon composite primary particles each comprise silicon, a silicon oxide of the Formula SiO x , wherein 0<x<2, disposed on the silicon, and a first graphene disposed on the silicon oxide; and a shell disposed on and surrounding the core, the shell comprising a second graphene.

METHOD FOR PROCESSING METAL POWDER

A method for processing powdered starting materials includes a powdered material created and packaged under a protective gas atmosphere such that a protective gas is also present in the package, and the packaged powdered material is unpacked by a user and sent for further processing, wherein a gas detectable with sensors is supplied to the protective gas during packaging and/or in the packaging, or the protective gas is a gas that can be detected with sensors and the manufacturer and packager of the powdered material and/or the end user will examine the package with sensors to detect an escape of the detectable gas. 1. A method for processing powdered starting materials for generative manufacturing methods , comprising:producing and packaging a powdered material under a protective gas atmosphere;providing a protective gas in the packaging for the powdered material;unpacking the packaged powdered material and sending the packaged powdered material for further processing;supplying a gas that is detectable by sensors to the protective as during at least one of the packaging, and in a package for the powdered material; andtesting the package with sensors for the escape of the gas by at least one of manufacturers and packagers of the powdered material, and an end user of the powdered material.2. The method according to claim 1 , wherein the packaging occurs under the protective gas using the gas detectable by the sensors claim 1 , and further comprising at least one of a vacuum claim 1 , atmospheric pressure claim 1 , and an excess pressure results in the package.3. The method according to claim 1 , wherein the gas that is detectable by the sensors is selected from the group consisting of hydrogen (H) claim 1 , and helium (He).4. The method according to claim 4 , wherein the gas selected and used comprises up to 4% hydrogen claim 4 , and up to 100% helium.5. The method according to claim further comprising:providing an interior pressure-sensitive region on the packaging; ...

Polymer pelletization via melt fracture

Polymer pellets are formed using air to influence the separation of polymer from a polymer melt. In accordance with one or more embodiments, a polymer material is extruded through a nozzle to form a polymer melt extending from the nozzle. A non-uniform thickness is generated in the polymer melt using a gas or gasses to apply a drag force to the polymer melt. This drag force reduces a thickness of a portion of the polymer melt adjacent the nozzle, and the polymer melt is fractured into discrete droplets at the reduced thickness. The discrete droplets are then solidified to form pellets.

Silica-Graphenic Carbon Composite Particles and Elastomeric Materials Including Such Particles

Composite particles may be produced by drying slurries containing silica particles and graphenic carbon particles in a liquid carrier. Elastomeric formulations comprising a base elastomer composition and the silica-graphenic carbon composite particles are also disclosed. The formulations possess favorable properties such as increased stiffness and are useful for many applications such as tire treads.

UREA GRANULATION PROCESS

A process of granulation of a urea melt, comprising: adding a first additive containing carboxymethyl starch to one or more first stage(s) of the granulation process, to form a carcarboxymethyl starch containing inner layer of urea granules, and adding a second additive containing calcium lignosulfonate to one or more second stage(s) of the granulation process, downstream said first stages, to form granules with a coating containing calcium lignosulfonate. 116-. (canceled)17. A urea granular product comprising granules made of at least 96% urea with a layer containing carboxymethyl starch and a coating layer containing calcium lignosulfonate.18. The urea product according to claim 17 , wherein the carboxymethyl starch containing layer has a thickness of 0.6 to 1.05 mm and the coating layer has a thickness of 0.1 to 0.2 mm.19. The urea product according to claim 17 , wherein the carboxymethyl starch containing layer contains 0.1% to 0.8% in weight of carboxymethyl starch and the coating layer contains 0.3% to 1% in weight of calcium lignosulfonate.20. The urea product according to claim 17 , wherein the urea product is obtainable with a process of granulation of a liquid urea melt containing at least 96% wt urea claim 17 , the granulation process comprising:adding a first additive containing carboxymethyl starch to one or more first stage(s) of the granulation process;performing one or more second stage(s) of the granulation process downstream said one or more first stage(s);wherein no amount of said first additive is added to said one or more second stage(s) of the granulation process. The present invention relates to a process for granulation of urea and to a granular urea product.Granulation is one of the known techniques to convert a highly concentrated urea-containing liquid, e.g. a urea melt, into a solid granular urea product.An overview of the urea granulation can be found in the literature, for example in the Ullmann's Encyclopedia of industrial chemistry. ...

ULTRAHIGH EFFICIENCY SPRAY DRYING APPARATUS AND PROCESS

The disclosure relates to ultrahigh efficiency spray drying systems and processes, utilizing induction of localized turbulence in a drying fluid flow stream to produce spray dried product, having particular utility for low temperature spray drying operations. In a specific implementation, a method of processing a spray dryable liquid composition to form a spray dried product includes the steps of: generating a spray of the spray dryable liquid composition; contacting the spray of spray dryable liquid composition in a spray drying contact zone with a stream of primary drying fluid; injecting pressurized secondary drying fluid into the stream of primary drying fluid in the spray drying contact zone at multiple loci thereof to provide localized turbulence at said multiple loci; and recovering the spray dried product from the spray drying contact zone. Systems of the present disclosure are effective in achieving high-rate production of dry powder spray dried products, with substantially reduced capital equipment costs, energy requirements, and operating expenditures. 1. A spray drying system , comprising:(a) a spray drying vessel comprising: (i) an interior volume arranged to receive an atomized spray-dryable material and drying fluid for contacting of the atomized spray-dryable material with the drying fluid in the interior volume; (ii) at least one drying fluid inlet by which the drying fluid is introduced into the interior volume for said contacting; and (iii) a spray-dried material outlet communicating with the interior volume, arranged to discharge spray-dried powder and effluent drying fluid from the vessel;(b) an atomizer adapted to receive a spray-dryable material and discharge the atomized spray-dryable material into the interior volume of the vessel for said contacting;(c) at least one turbulator adapted to generate turbulence in the drying fluid in the interior volume of the vessel;{'sup': '3', '(d) a process control unit adapted to regulate flow rate of ...

POROUS GRANULES CONTAINING MIXTURE OF RUBBER AND SILICA POWDERS

Granules containing mixtures of silica powder and cross-linked rubber powder are used in the manufacture of battery separators or vehicle tires. A granule contains silica and rubber powders in proportional amounts that form a silica powder carrier within which rubber powder particles are distributed. Incorporating silica-rubber granules in the manufacturing process of polyethylene separators offers a way to limit water loss in and improve the cycle life of a deep cycle lead-acid battery. Incorporating silica-rubber granules in the manufacturing process of vehicle tires affords advantages including easier material handling, reduced production of dust, and reduction in the number of ingredients measured and added to the formulation. 1. A silica-rubber granule , comprising:a combination including a first amount of a silica component and a second amount of a rubber component, the first amount of the silica component being greater than the second amount of the rubber component, the combination of the first and second amounts of the respective silica and rubber components comprised in a granule in which the silica component of the granule is a carrier within which the rubber component is distributed.2. The silica-rubber granule of claim 1 , wherein the granule comprises a compression-formed granule established by the combination of the first and second amounts of the respective silica and rubber components.3. The silica-rubber granule of claim 2 , wherein the silica component comprises a spray-dried silica component claim 2 , the rubber component comprises a spray-dried rubber component claim 2 , or both.4. The silica-rubber granule of claim 3 , wherein both the spray-dried silica component and the spray-dried rubber component are spray dried individually or in combination.5. The silica-rubber granule of claim 3 , wherein the spray-dried rubber component comprises a spray-dried rubber latex or spray-dried rubber slurry.6. The silica-rubber granule of claim 1 , wherein the ...

APPARATUS AND PROCESS FOR FORMING PARTICLES

An apparatus and process for forming particles. 1. An apparatus for forming particles , said apparatus comprising:a feed pipe;a gas feed line mounted in fluid communication with said feed pipe;a mill downstream of said gas feed line and in line with said feed pipe;a distributor downstream of said mill and in fluid communication with said feed pipe,wherein said distributor comprises a plurality of apertures; anda conveyor beneath said cylinder and movable in translation relative to said distributor.2. An apparatus according to claim 1 , wherein said distributor comprises:a stator in fluid communication with said feed pipe;a cylinder rotationally mounted about said stator and rotatable about a longitudinal axis of said cylinder, wherein said cylinder has a periphery and said cylinder comprises said plurality of apertures disposed about said periphery, wherein said apertures are intermittently in fluid communication with said stator as said cylinder rotates about said stator.3. An apparatus according to claim 2 , wherein said apparatus comprises a feed pump in line with said feed pipe claim 2 , wherein said gas feed line and said mill are positioned in line between said feed pump and said stator.4. An apparatus according to claim 2 , wherein said gas feed line comprises a flow regulator.5. An apparatus according to claim 2 , wherein said mill is an in-line rotor-stator mill.6. An apparatus according to claim 1 , wherein said apparatus comprises a batch mixer upstream of said feed pipe.7. An apparatus according to claim 1 , wherein said mill is an in-line rotor-stator mill. Apparatus and process for forming particles.There are a variety of approaches for forming particles from flowable masses. Often the flowable mass is a melt. Melts are commonly prepared by providing one or more raw materials in a molten form into a batch mixer. The mixer is sized and dimensioned to provide for a desired residence time for the raw material or materials in the mixer to sufficiently mix ...

Taxane Particles and Their Use

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cmand about 0.15 g/cm, and/or a specific surface area (SSA) of at least 18 m/g, 20 m/g, 25 m/g, 30 m/g, 32 m/g, 34 m/g, or 35 m/g. Methods for making and using such compositions are also provided. 1. A composition , comprising particles including at least 95% by weight of a taxane , or a pharmaceutically acceptable salt thereof , wherein the particles have a specific surface area (SSA) of at least 18 m/g.2. The composition of claim 1 , wherein the taxane is selected from the group consisting of paclitaxel claim 1 , docetaxel claim 1 , and cabazitaxel claim 1 , or a pharmaceutically acceptable salt thereof.3. The composition of claim 2 , wherein the taxane is paclitaxel or a pharmaceutically acceptable salt thereof.4. The composition of claim 3 , wherein the paclitaxel particles have a mean bulk density between about 0.050 g/cmand about 0.12 g/cm.5. The composition of claim 3 , wherein the paclitaxel particles have a specific surface area (SSA) of at least 20 m/g.6. The composition of claim 3 , wherein the paclitaxel particles have a SSA of between about 18 m/g and about 40 m/g.7. The composition of claim 3 , wherein the paclitaxel particles have a SSA of between about 20 m/g and about 40 m/g.8. The composition of claim 2 , wherein the taxane is docetaxel or a pharmaceutically acceptable salt thereof.9. The composition of claim 8 , wherein the docetaxel particles have a mean bulk density between about 0.050 g/cmand about 0.12 g/cm.10. The composition of claim 8 , wherein the docetaxel particles have a SSA of at least 20 m/g.11. The composition of claim 8 , wherein the docetaxel particles have a SSA of between about 18 m/g and about 50 m/g.12. The composition of claim 8 , wherein the docetaxel particles have a SSA of between about 20 m/g and about 50 m/g.13. The composition ...

PEDOSPHERE-IMPROVING GRANULATE, METHOD FOR PRODUCING SAME, AND USE THEREOF

A method for producing a pedosphere-improving granulate () and granulate itself, the method includes a) producing a raw material dispersion including at least one inorganic secondary phosphate () and at least one reaction agent () in a liquid phase (), b) separating part of the liquid phase () from the raw material dispersion, c) granulating and/or extruding the remaining raw material dispersion with a reduced liquid phase (), d) either returning the liquid phase () separated in process step b) to process step a) in order to produce a raw material dispersion without at least partly separating () heavy metals or at least partly separating heavy metals () from the liquid phase () separated in process step b) and discharging the heavy metals () out of the process and subsequently returning the separated heavy metal reduced liquid phase () in order to produce a raw material dispersion in a manner analogous to process step a) and/or returning the liquid phase to process step c), and e) repeating process steps a) to d). 16. Pedosphere-improving granules () produced using a method comprising:{'b': 1', '1', '4', '1', '2, 'a) production of a raw material dispersion comprising at least one inorganic secondary phosphate () and at least one reactant (), the proportion of a liquid phase () in the raw material dispersion being greater than 30%, with an incubation time between inorganic ones Secondary phosphate () and reactant () between 1 to 100 minutes,'}{'b': '4', 'b) separation of part of the liquid phase () of the raw material dispersion,'}{'b': '4', 'c) granulation, extrusion, or a combination thereof of the remaining raw material dispersion with reduced liquid phase (),'}{'b': 4', '5', '7', '4', '7', '4, 'd) either recycling the liquid phase () separated in process step b) without at least partially separating heavy metal () into process step a) to produce a raw material dispersion or at least partially separating heavy metals () from the liquid phase () separated in ...

DIRECTLY COMPRESSIBLE GRANULAR MICROCRYSTALLINE CELLULOSE BASED EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF

An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API. 1. A composition comprising:about 90% to about 99% microcrystalline cellulose; andabout 1% to about 10% at least one binder;wherein the microcrystalline cellulose and binder are indistinguishable when viewed with a SEM, thereby forming substantially homogeneous-particles.2. The composition of wherein the composition includes:about 95% to about 99% microcrystalline cellulose; andabout 1% to about 5% at least one binder.3. The composition of wherein the composition includes:about 97% to about 99% microcrystalline cellulose; andabout 1% to about 3% at least one binder.4. The composition of wherein the binder includes hydroxypropyl methylcellulose.5. The composition of wherein the excipient is formed by homogenizing/spray dry granulating an aqueous slurry comprised of the microcrystalline cellulose and binder.6. The composition of wherein the aerated bulk density is 0.2-0.3 g/cc.7. A method or making an excipient comprising:mixing a microcrystalline cellulose (MCC) slurry with a cross-linked polyvinylpyrrolidone slurry to form a MCC/cross-linked polyvinylpyrrolidone slurry; ...

METHOD FOR MANUFACTURING GRAPHENE BALLS

A method for preparing graphene balls, the method including, 1. A method for preparing graphene balls comprising ,a) preparing a dispersion which includes, a graphene oxide, a reducing agent ranging from a monosaccharide to a polysaccharide, and ammonia water; andb) spraying and drying the dispersion.2. The method of claim 1 , wherein the step a) comprises claim 1 ,a1) preparing a first dispersion which includes a graphene oxide and a reducing agent ranging from a monosaccharide to a polysaccharide; anda2) mixing the first dispersion with ammonia water to prepare a second dispersion.3. The method of claim 1 , wherein the reducing agent ranging from a monosaccharide to a polysaccharide is one or more selected from a group consisting of glucose claim 1 , fructose claim 1 , galactose claim 1 , sucrose claim 1 , maltose and lactose.4. The method of claim 1 , wherein the dispersion contains 0.1 to 2% by weight of the graphene oxide.5. The method of claim 1 , wherein the dispersion contains 0.3 to 3% by weight of the reducing agent.6. The method of claim 1 , wherein the dispersion contains 1 to 10% by weight of the ammonia water.7. The method of claim 2 , wherein the step a2) is performed at 80 to 100° C. for 30 minutes to 2 hours.8. The method of claim 1 , wherein the step b) is performed at 150 to 250° C.9. The method of claim 1 , further comprising claim 1 ,drying at 50 to 70° C. for 12 to 48 hours after the step b). This application claims priority to Korean Patent Application No. 10-2016-0067858 filed on Jun. 1, 2016, and all the benefits accruing therefrom under 35 U.S.C. § 119, the contents of which is incorporated by reference in its entirety.The present disclosure relates to a method of preparing graphene balls, uniform in size, that are easy to handle.Graphene is a carbon nanomaterial having a planar structure wherein carbon atoms connected by a spbond. Graphene is being used in a wide range of fields including batteries, super capacitors, nanocomposites, ...

Toner, developer and method of manufacturing toner

A toner is provided. The toner includes a binder resin, a colorant, a release agent and an external additive. The toner has an average circularity of from 0.965 to less than 0.985. The toner has BET specific surface area of less than 1.20 m 2 /g after liberation treatment of external additive.

APPARATUS AND METHOD FOR SPRAY DRYING

An electrostatic spray dryer for drying liquid into powder including an elongated body defining a drying chamber, a spray nozzle assembly at one end of the drying chamber and a filter element housing and powder collection chamber at an opposite end. A non-structural non-metallic liner is disposed within the elongated body in spaced relation to an inner wall surface for defining an internal drying zone. The liner is releasably supported within the body for enabling selective removal and replacement following a particular usage. The illustrated elongated body has a modular construction comprising a plurality of modules, with at least one being selectively removable and replacement for altering the length of the drying chamber for a particular spray application. The liner also is replaceable with a liner of a length corresponding to the altered length of the drying chamber or with a different diameter for a particular usage. 1. An electrostatic spray drying system for drying liquid into powder comprising:an elongated structural body supported in upright position;a closure arrangement at opposite upper and lower ends of the elongated body for forming a drying chamber within said elongated body;a non-structural non-metallic liner disposed within said elongated body in spaced relation to an inner wall surface of the elongated body for defining an internal drying zone within said elongated body;one of said closure arrangements including a drying gas inlet for coupling to a drying gas source and for directing drying gas into said drying zone;an electrostatic spray nozzle assembly supported in one of the closure arrangements;said electrostatic spray nozzle assembly including a nozzle body having a discharge spray tip assembly at a downstream end thereof for directing liquid to be dried into said drying zone;said electrostatic spray nozzle assembly having a liquid inlet for coupling to a supply of liquid to be discharged into the drying zone and an electrode for coupling to ...

Freezing temperature controllable spray freezing tower for preparing micron-sized spherical ice particles

A freezing temperature controllable spray freezing tower for preparing micron-sized spherical ice particles includes a tower body, an atomization system, a material feeding system, a circulatory air supplying system, a refrigeration system and a tower wall cooling and thermal insulation system. An air storage cavity is formed at a top of the tower body, a freezing chamber is formed inside the tower body, a material collecting chamber is formed at a bottom of the tower body. The atomization system is in communication with the air storage cavity, the material feeding system is in communication with the atomization system, the circulatory air supplying system is in communication with the bottom of the freezing chamber and the refrigeration system respectively, the refrigeration system is connected to the air storage cavity and a tower wall of the tower body. Thus the operation is convenient and simple.

INCREASE IN SILICON CONTENT IN THE PREPARATION OF QUARTZ GLASS

A quartz glass body and a process for the preparation of a quartz glass body is disclosed. In one aspect, the process includes providing a silicon dioxide granulate from a pyrogenic silicon dioxide powder, making a glass melt out of the silicon dioxide granulate and making a quartz glass body out of at least part of the glass melt. In at least one process a silicon component different from silicon dioxide is added. One aspect further relates to a quartz glass body which is obtainable by this process. A light guide, an illuminant and a formed body, are each obtainable by further processing of the quartz glass body. 126-. (canceled)27. A process for the preparation of a quartz glass body comprising: providing a pyrogenic silicon dioxide powder; and', 'processing the silicon dioxide powder to obtain a silicon dioxide granulate,', 'wherein the silicon dioxide granulate has a greater particle diameter than the silicon dioxide powder;, 'providing a silicon dioxide granulate, wherein this provision comprisesmaking a glass melt out of the silicon dioxide granulate; andmaking a quartz glass body out of at least part of the glass melt;wherein in at least one of the process steps a silicon component different from silicon dioxide is added.28. The process according to claim 27 , wherein in the processing a silicon dioxide granulate with granules is formed claim 27 , wherein the granules have a spherical morphology claim 27 , wherein the processing comprises a spray granulation or a roll granulation.29. The process according to claim 27 , wherein the silicon component is silicon claim 27 , a silicon-hydrogen compound claim 27 , a silicon-oxygen compound or a silicon-hydrogen-oxygen compound.30. The process according to claim 27 , wherein the silicon component is added as powder.31. The process according to claim 27 , wherein the addition of the silicon component takes place in processing the silicon dioxide powder.32. The process according to claim 27 , wherein the silicon ...

Nozzle Assembly and Methods for Use

The present disclosure provides an apparatus and methods of use for isolating particles. An example apparatus includes (a) a vessel defining a pressurizable chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet of the pressurizable chamber at the proximal end of the vessel, (c) a nozzle positioned within the pressurizable chamber, wherein the nozzle includes an inlet tube in fluid communication with the inlet of the pressurizable chamber, wherein the nozzle includes an outlet aperture, wherein the nozzle is adjustable to alter a distance between the proximal end of the vessel and the outlet aperture of the nozzle, and wherein the nozzle is adjustable to alter an angle between a longitudinal axis of the vessel and a longitudinal axis of the nozzle, and (d) an outlet of the pressurizable chamber at the distal end of the vessel. 1. A nozzle assembly , comprising:a vessel defining a pressurizable chamber, wherein the vessel includes a distal end and a proximal end;an inlet of the pressurizable chamber at the proximal end of the vessel;a nozzle positioned within the pressurizable chamber, wherein the nozzle includes an inlet tube in fluid communication with the inlet of the pressurizable chamber, wherein the nozzle includes an outlet aperture, wherein the nozzle is adjustable to alter a distance between the proximal end of the vessel and the outlet aperture of the nozzle, and wherein the nozzle is adjustable to alter an angle between a longitudinal axis of the vessel and a longitudinal axis of the nozzle; andan outlet of the pressurizable chamber at the distal end of the vessel.2. The nozzle assembly of claim 1 , further comprising:a second inlet of the pressurizable chamber at the proximal end of the vessel.3. The nozzle assembly of claim 1 , wherein the inlet of the pressurizable chamber is in fluid communication with a first reservoir and a second reservoir.4. The nozzle assembly of claim 2 , wherein the inlet of the pressurizable chamber ...

METHOD FOR PREPARING SILICA NANOPARTICLES

A method for preparing silica nanoparticles includes the steps of: slowly titrating a sodium silicate solution with an acid solution to obtain a silicic acid-containing solution; continuously stirring the silicic acid-containing solution; slowly titrating the silicic acid-containing solution with the acid solution to obtain a silicic acid-enriched solution; continuously stirring the silicic acid-enriched solution; collecting the silicic acid-enriched solution as a silica nanoparticle precursor solution when a pH value of the silicic acid-enriched solution reaches a target pH value; and subjecting the silica nanoparticle precursor solution to a flame spray pyrolysis or a drying-grinding-calcining treatment. 1. A method for preparing a silica nanoparticle precursor solution , comprising the steps of:a) pre-treating a siliceous rock to form a sodium silicate solution;b) slowly titrating the sodium silicate solution with an acid solution under stirring until a pH value of the sodium silicate solution is reduced by a predetermined value so as to obtain a silicic acid-containing solution;c) continuously stirring the silicic acid-containing solution until a pH value of the silicic acid-containing solution becomes constant;d) slowly titrating the silicic acid-containing solution with the acid solution under stirring until the pH value of the silicic acid-containing solution is reduced by the predetermined value so as to obtain a silicic acid-enriched solution having a silicic acid amount which is greater than that of the silicic acid-containing solution by a predetermined increment; ande) continuously stirring the silicic acid-enriched solution until the pH value of the silicic acid-enriched becomes constant if a pH value of the silicic acid-enriched solution does not reach a target pH value.2. The method according to claim 1 , further comprising a step of collecting the silicic acid-enriched solution as the silica nanoparticle precursor solution when the pH value of the ...

SPRAY DRYER SYSTEM AND METHOD

A spray drying system for drying liquid into powder including an elongated body and a closure arrangement at opposite upper and lower ends of the elongated body for forming a drying chamber within the elongated body. One of the closure arrangements including a drying gas inlet for introducing drying gas into the drying chamber. A spray nozzle assembly is supported in one of the closure arrangements. The lower end closure arrangement including a powder collection vessel for collecting powder dried in the drying chamber. The powder collection vessel is configured such that a blanketing gas may be directed into the interior of the powder collection vessel to blanket the powder in the powder collection chamber and thereby protect the powder from exposure to the drying gas from the drying chamber. 1. A spray drying system for drying liquid into powder comprising:an elongated body supported in an upright position;a closure arrangement at opposite upper and lower ends of the elongated body for forming a drying chamber within the elongated body;one of the closure arrangements including a drying gas inlet for coupling to a drying gas source and for directing drying gas into the drying chamber;an electrostatic spray nozzle assembly supported in one of the closure arrangements;the electrostatic spray nozzle assembly including a nozzle body having a liquid inlet for coupling to a supply of liquid, a discharge spray tip assembly at a downstream end for directing liquid to be dried into the drying chamber and an electrode for coupling to an electrical source for electrically charging liquid passing through the spray nozzle assembly into the drying arranged; andthe lower end closure arrangement including a powder collection vessel for collecting powder dried in the drying chamber, an upper end of the powder collection vessel being in communication with the drying chamber, the powder collection vessel including a blanket gas inlet near the upper end of the powder collection vessel ...

Cellulose ether powders

Provided is a method of making methylcellulose-type ether in powder form, said method comprising (a) providing a solution of said methylcellulose-type ether in water, and (b) then separating said methylcellulose-type ether from said water to produce dried methylcellulose-type ether, with the proviso that either (i) step (b) produces said methylcellulose-type ether in powder form, or (ii) after step (b), said method additionally comprises a step (c) of subjecting said dried methylcellulose-type ether to mechanical stress to produce said methylcellulose-type ether in powder form.

Fluidized bed water gas shift catalyst

The present invention relates to an aqueous gas-converting catalyst composition comprising: an active component; a support; an inorganic binder; at least one accelerator selected from the group consisting of cobalt oxide, molybdenum oxide, nickel oxide, calcium oxide, barium oxide, strontium oxide, magnesium oxide, zirconium oxide, manganese oxide and barium titania; and at least one stabilizer selected from the group consisting of magnesium oxide, zirconium oxide, stabilized zirconia, and hydrotalcite. The catalyst according to the present invention can effectively capture and separate carbon dioxide due to the excellent physical properties thereof such as packing density and abrasion resistance, and high CO conversion. Also, according to the present invention, mass production is facilitated by applying a spraying technique, and overall costs are lowered because of high yield. Thus, the present invention can be applied as a low cost pre-combustion CO2 capturing technique to an integrated gasification combined cycle, fuel cells, coal liquefaction, compound production, and the like.

BEADLETS COMPRISING CAROTENOIDS

The present invention relates to process for producing beadlets comprising at least one carotenoid and matrix material, which comprise wax(es) and/or fat(s) with a melting point of between 40 to 85° C., as well as to the production of such beadlets and to the use of such beadlets in compositions. 1. A process for producing beadlets using a spray chilled process or a spray cooling process , wherein the process comprises the following steps:(a) forming a mixture by mixing (i) 25 wt-% to 45 wt-%, based on the total weight of the beadlets, of at least one carotenoid and (ii) 55 wt-% to 75 wt-% of a matrix material which comprises at least one unsaturated (non-hydrogenated), partially saturated (partially hydrogenated) or fully saturated (fully hydrogenated) wax and/or fat having a melting point of from 40° C. to 85° C., and{'b': '1000', '(b) atomizing the mixture of the at least one carotenoid and the matrix material into a chamber and contacting the atomized mixture within the chamber with an air stream which is sufficiently cool to cause droplets of the mixture to solidify and thereby form beadlets having an average particle diameter of 50 μm to μm and with the at least one carotenoid having a particle size (d0.9) inside the beadlets of below 30 μm.'}2. The process according to claim 1 , which further comprises grinding the mixture of the at least one carotenoid and matrix material before atomizing.4. The process according to claim 1 , wherein the at least one carotenoid is present in the mixture in an amount of 25-40 wt-% claim 1 , based on the total weight of the beadlets=.5. The process according to claim 1 , wherein the at least one carotenoid is present in the mixture in an amount of 25-35 wt-% claim 1 , based on the total weight of the beadlets.6. The process according to claim 1 , wherein the melting point of the matrix material is 45° C. to 80° C.7. The process according to claim 1 , wherein the carotenoid is at least one selected from the group consisting of ...

SPRAY DRYER

An electrostatic spray drying system includes an electrostatic spray nozzle having a spray tip assembly arranged to discharge a supply of fluid into a drying chamber. The electrostatic spray nozzle is responsive to a duty cycle signal that determines periods at which the electrostatic spray nozzle is open to inject the fluid. A controller is programmed to activate a pulse width modulation (PWM) mode of operation for the electrostatic spray assembly, initiate a first timer, provide a first duty cycle signal to the electrostatic spray nozzle at a first PWM activation frequency while the first timer has not reached a first pulse duration, initiate a second timer when the first timer has reached the first pulse duration, and provide a second duty cycle signal to the electrostatic spray nozzle at a second PWM activation frequency while the second timer has not reached a second pulse duration. 1. An electrostatic spray drying system for drying liquid into powder comprising:a drying chamber;an electrostatic spray nozzle having a spray tip assembly arranged to discharge a supply of liquid into the drying chamber, the electrostatic spray nozzle being configured to discharge the supply of liquid based on a duty cycle signal provided to the electrostatic spray nozzle assembly, the duty cycle signal determining periods at which the electrostatic spray nozzle is open to inject the supply of liquid or closed;a controller associated with the electrostatic spray nozzle and operating to provide the duty cycle signal to the electrostatic spray nozzle, the controller being programmed and operating to:activate a pulse width modulation (PWM) mode of operation for the electrostatic spray assembly;initiate a first timer;provide a first duty cycle signal to the electrostatic spray nozzle at a first PWM activation frequency while the first timer has not reached a first pulse duration;initiate a second timer when the first timer has reached the first pulse duration; andprovide a second duty ...

Cut extrudate dispersal hood

A product-spreading hood assembly ( 10 ) for use with a die unit ( 128 ) includes a deflector ( 14 ) having wall structure defining a product inlet opening ( 90 ) and a product outlet opening ( 92 ); the deflector ( 14 ) is preferably generally frustoconical in shape and is supported by a housing ( 12 ). An optional air delivery assembly ( 16 ) allows air currents to be directed from the area of the inlet ( 90 ) towards outlet ( 92 ) to facilitate separation of discrete products. Advantageously, the air currents are delivered in a circumferential fashion about the die unit ( 128 ). Use of the hood assembly ( 10 ) serves to separate high moisture or “sticky” extrudates, thereby preventing agglomeration thereof.

Means for manufacturing micro-beads comprising thermoplastic polymer micro-particles

The present invention relates to means for manufacturing micro-beads (polymer micro-particles) comprising thermoplastic polymer and having the average particle size of 10 μm or less, and extending into the nano-range. An original filament comprising a thermoplastic polymer is passed through an orifice under an air pressure (P1) and guided to a spray chamber under a pressure (P2; where P1>P2). The original filament having passed through the orifice is heated and melted under irradiation by an infrared beam, and is sprayed in microparticulate form from the orifice by the flow of air generated by the pressure differential between P1 to P2, whereby micro-beads comprising thermoplastic polymer micro-particles having an average particle size of 10 μm or less, and even less than 1 μm are manufactured.

LIQUID FEEDING DEVICE FOR THE GENERATION OF DROPLETS

The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber. 1. Liquid feeding device for the generation of droplets , in particular for the use in a process line for the production of freeze-dried particles , witha droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, and wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.2. Liquid feeding device according to claim 1 , wherein the longitudinal axis of the liquid ...

EIFS FORMULATIONS WITH ENHANCE RAIN RESISTANCE

The present invention provides shelf-stable, non-cementitious dry mix compositions of inorganic non-cementious materials, such as sand, and water redispersible polymer powder (RDP) containing particles of a multi-stage acrylic copolymer having a calcium methacrylate salt group containing alkali-soluble resin outer stage and one or more inner stage, the particles further containing each of one or more nucleating agent having a boiling point of 150° C. to 500° C. and a water solubility of 3.5% or less, and one or more colloidal stabilizer, wherein the colloidal stabilizer and the multi-stage acrylic copolymer are contained in the same RDP particle. 1. A shelf-stable , non-cementitious dry mix composition comprising i) one or more extenders , pigments , fillers , or their mixtures , in a total % PVC of from 60-98% , and ii) from 10-20 wt. % , based on the total weight of the composition solids , of a water redispersible polymer powder (RDP) containing particles of a multi-stage acrylic copolymer having a calcium methacrylate salt group containing alkali-soluble resin outer stage and one or more inner stage , the particles further containing each of one or more nucleating agent having a boiling point of 150° C. to 500° C. and a water solubility of 3.5% or less , and one or more colloidal stabilizer , wherein when the multi-stage acrylic copolymer is dispersed in water the one or more inner stage comprises an acrylic (co)polymer having a glass transition temperature (Tg) of from −40 to 50° C. , calculated using the Fox equation , and wherein the weight ratio of the alkali-soluble resin outer stage to the one or more inner stage(s) range from 1:19 to 2:3 , wherein the colloidal stabilizer and the multi-stage acrylic copolymer are contained in the same RDP particle.2. The composition as claimed in claim 1 , wherein when the multi-stage acrylic copolymer is dispersed in water the one or more inner stage comprises an acrylic (co)polymer having a glass transition temperature ...

SPRAY DRYER WITH IMPROVED EXHAUST GAS FILTRATION SYSTEM

A spray dryer for drying liquid into powder including an elongated drying chamber, a spray nozzle assembly at an upper end of the drying chamber and a filter element housing and powder collection chamber at a lower end of the drying chamber. The filter element housing comprises a plurality of cylindrical filter elements supported from a wall of an exhaust chamber that communicates with an exhaust gas outlet of the filter element housing. In one embodiment, the filter element housing includes an inner downwardly opening cylindrical shroud surrounding the filter elements which defines an outer annular powder and drying gas passageway communicating with the powder collection chamber, and the exhaust chamber is defined by a downwardly opening conical plenum having an outer conical surface for directing drying gas and powder about the shroud into the powder collection chamber. Filter elements each have a respective reverse gas pulse cleaning device. 1. A spray dryer for drying liquid into powder comprising:an elongated body supported in upright position;a closure arrangement at opposite upper and lower ends of the elongated body for forming a drying chamber within said elongated body;a spray nozzle assembly supported in said upper end closure arrangement;said spray nozzle assembly including a nozzle body having a liquid inlet for coupling to a supply of liquid and a discharge spray tip assembly at a downstream end for directing liquid to be dried into said drying chamber;said upper end closure arrangement having a drying gas inlet for introducing drying gas into said drying chamber for drying liquid directed into the drying chamber into powder;said closure arrangement at the lower end of said elongated body including powder collection chamber for collecting powder dried in said drying zone and a filter housing having an exhaust gas outlet for filtering drying gas borne powder from drying gas exiting the powder collection chamber through said filter element housing and ...

Process for Producing Dispersion Powders

A process for producing dispersion powders by means of spray drying of aqueous polymer dispersions and addition of antiblocking agents in a rotary atomization dryer, wherein the antiblocking agent is conveyed by means of delivery air, wholly or partly, into an annular gap which is formed by a moulding arranged concentrically around the housing of the rotary atomizer, and which ends at a distance above the upper edge of the atomizer plate of the rotary atomizer.

Method and Apparatus for the Granulation of a Liquid, in Particular for the Granulation of Urea

Process and apparatus for granulation of a liquid phase, wherein a polydispersed flow of droplets of said liquid phase is generated, with descending motion in contact with solidification air along a substantially vertical granulation path, and wherein inside said polydispersed flow, small-sized droplets solidify producing solid particles, and said solid particles grow by collision with other droplets of liquid; in some embodiments the product obtained with this new granulation method can be grown with the conventional method. 1. A process of granulation of a liquid phase , the process comprising generating a polydispersed flow of droplets of said liquid phase , with a descending motion in contact with solidification air along a substantially vertical granulation path ,wherein inside said polydispersed flow, small-sized droplets solidify producing solid particles, and said solid particles grow by collision with other droplets of liquid.2. The process according to claim 1 , wherein said polydispersed flow of droplets of the liquid phase comprises droplets having a characteristic size or diameter that is variable in a range between 0.1 mm and about 2.5 mm.3. The process according to claim 1 , comprising feeding at least a part of the air along said granulation path through an air-permeable wall claim 1 , wherein said permeable wall delimits at least the initial part of said path.4. The process according to claim 1 , comprising introducing the entire liquid phase supply claim 1 , in the form of said polydispersed flow of droplets claim 1 , into a head section of said granulation path.5. The process according to claim 1 , comprising introducing a part of the liquid phase supply into a head section of said granulation path claim 1 , and introducing the remaining part of said liquid phase into at least one intermediate section of said path.6. The process according to claim 1 , wherein the solidification air flows with descending motion substantially in co-current with the ...

Spray drying

A method of preparing dry core-shell microcapsules from an aqueous dispersion of such capsules, comprising spraying the dispersion through a two-fluid air-liquid nozzle into a heated chamber having an upper part and a lower part, the spraying taking place in the upper part and the lower part being provided with a means of continuous capsule removal. The method allows the drying of capsules with considerably reduced losses.

FLUID REACTOR

A fluid reactor for generating particulate fluids by collision, has a housing which encloses a collision chamber, a first fluid nozzle, and a second fluid nozzle oriented opposite thereto in a collinear manner, which is located directly opposite the first fluid nozzle in a jet direction of the first and second fluid nozzles in a common collision zone, at least one rinsing fluid inlet into the collision chamber arranged on a first side of the first fluid nozzle, and at least one product outlet out of the collision chamber arranged on a second side of the second fluid nozzle. 1. A fluid reactor for generating particulate fluids by collision , the fluid reactor comprising:having a housing which encloses a collision chamber;a first fluid nozzle;a second fluid nozzle oriented opposite to the first fluid nozzle in a collinear manner, and located directly opposite the first fluid nozzle in a jet direction of the fluid nozzle in a common collision zone;at least one rinsing fluid inlet into the collision chamber arranged on a first side of the first fluid nozzle; andat least one product outlet out of the collision chamber arranged on a second side of the second fluid nozzle,wherein rinsing-fluid-conducting structures are designed as parallel channels on a side of the first fluid nozzle, which are suitable in the collision chamber, in an area of the collision zone, to produce a rinsing fluid flow directed in the jet direction of the first fluid nozzle.2. The fluid reactor according to claim 1 ,wherein, in the collision chamber on the second side of the second fluid nozzle, an open-pored or sponge-like structured impact wall is formed.3. The fluid reactor according to claim 1 , wherein a projection is formed claim 1 , which creates claim 1 , in an area of a head of the first fluid nozzle claim 1 , a concentrically arranged tapered first fluid conducting space in the collision chamber around the first fluid nozzle.4. The fluid reactor according to claim 1 , wherein a projection ...

Heater Tube for Molten Metal Immersion

A heater tube for molten metal immersion 1 has a cylindrical heater housing part 4 equipped with a closed end 2 and an open end 3 , wherein the heater housing part 4 comprises silicon nitride, a compound comprising yttrium, and a compound comprising magnesium. The heater housing part 4 has a surface roughness Ra of an outer circumferential surface of the heater housing part 4 is between 0.5 μm and 10 μm, inclusive.

Taxane Particles and Their Use

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cmand about 0.15 g/cm, and/or a specific surface area (SSA) of at least 18 m/g, 20 m/g, 25 m/g, 30 m/g, 32 m/g, 34 m/g, or 35 m/g. Methods for making and using such compositions are also provided. 1. A method for treating a bladder tumor , comprising administering to a subject with a bladder tumor an amount effective to treat the tumor of a composition comprising particles including at least 95% by weight of a taxane , or a pharmaceutically acceptable salt thereof , wherein the particles have a specific surface area (SSA) of at least 18 m/g , and wherein the taxane particles include both agglomerated taxane particles and non-agglomerated taxane particles.2. The method of claim 1 , wherein the taxane is selected from the group consisting of paclitaxel claim 1 , docetaxel claim 1 , and cabazitaxel claim 1 , or a pharmaceutically acceptable salt thereof.3. The method of claim 2 , wherein the taxane is paclitaxel or a pharmaceutically acceptable salt thereof.4. The method of claim 3 , wherein the paclitaxel particles have a mean bulk density between about 0.050 g/cmand about 0.12 g/cm.5. The method of claim 3 , wherein the paclitaxel particles have a specific surface area (SSA) of at least 20 m/g.6. The method of claim 3 , wherein the paclitaxel particles have a SSA of between about 18 m/g and about 40 m/g.7. The method of claim 3 , wherein the paclitaxel particles have a SSA of between about 20 m/g and about 40 m/g.8. The method of claim 2 , wherein the taxane is docetaxel or a pharmaceutically acceptable salt thereof.9. The method of claim 8 , wherein the docetaxel particles have a mean bulk density between about 0.050 g/cmand about 0.12 g/cm.10. The method of claim 8 , wherein the docetaxel particles have a SSA of between about 18 m/g and about 50 m/g.11. The method of claim ...

PRODUCTION OF A SOLID CHEMICAL PRODUCT

Method for solidifying a chemical product () which is in melt form, comprising the following steps: subjecting a first stream () of said chemical product to a prilling stage, with production of prills () of varying diameter; feeding said prills () to a screening device, which separates them according to their diameter into at least a first fraction () and a second fraction (), the average diameter of the prills of said first fraction () being smaller than the average diameter of the prills of said second fraction (); subjecting a second stream () of said chemical product and the first fraction () of prills to a granulation stage, with the production of granules (). 1) A method for solidifying a chemical product which is in melt form , comprising the following steps:subjecting a first stream of said chemical product to a prilling stage, with production of prills of varying diameter;feeding said prills to a screening device, which separates them according to their diameter into at least a first fraction and a second fraction, the average diameter of the prills of said first fraction being smaller than the average diameter of the prills of said second fraction;subjecting a second stream of said chemical product to a granulation stage and feeding to said stage the first fraction of prills, said prills acting as seeds for the granulation, producing granules;and wherein said second fraction is exported and sent to storage.2) The method according to claim 1 , wherein the prills of said first fraction have an average diameter not greater than 1.7 mm.3) The method according to claim 1 , wherein said granulation stage is performed in a fluid bed fed with air.4) The method according to claim 1 , wherein said chemical product is urea.5) A solidification section of a chemical product which is in melt form claim 1 , comprising at least:a prilling tower, which receives a first stream of said chemical product, producing prills of varying diameter;a screening device, which separates ...

PROCESS FOR PREPARING A POLYAMIDE, A NYLON SALT TO BE USED THEREIN AND A PROCESS FOR MAKING THE SALT

Processes for preparing a polyamide, a polyamide material obtained by such processes, a nylon salt to be used therein, and processes for making the nylon salt are disclosed. The processes for preparing the polyamide include a direct solid state polymerization process. The salt used herein is a granulate material, prepared by a process, comprising spraying an aqueous solution comprising a diamine and a dicarboxylic acid dissolved in an aqueous medium, or an aqueous slurry comprising a diammonium dicarboxylate salt dispersed in an aqueous medium directly obtained from such an aqueous solution, onto or in a fluidized bed of diammonium dicarboxylate salt particles, while evaporating the aqueous medium, thereby forming a granulate salt material. 1. A granulate salt material comprising a diammonium dicarboxylate salt which is a fluidized bed spray granulation product of an aqueous solution or an aqueous slurry comprising a diammonium dicarboxylate salt dissolved or dispersed in an aqueous medium.2. The granulate salt material according to claim 1 , wherein the salt is obtained by a process.3. The granulate salt material according to claim 1 , wherein the salt has the following physical properties:(a) a particle size distribution with a median particle size (d50) in the range of 200-1000 μm, measured by laser granulometry with the method according to ISO 13320-1 at 20° C., and{'sup': '3', '(b) a tapped bulk density in the range of 350-750 kg/m, measured by the method according to ASTM D6393.'}4. A process for preparing a polyamide claim 1 , comprising direct solid state polymerization of a diammonium dicarboxylate salt claim 1 , wherein the salt is a granulate salt material prepared by fluidized bed spray granulation.5. The process according to claim 4 , wherein the granulate salt material is a salt.6. The process according to claim 4 , wherein the direct solid state polymerization is carried out in a reactor comprising an agitator claim 4 , or in a rotatable reactor claim ...

PARTICULATE MATERIALS

Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μm suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v. The aerosol formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the hydrofluorocarbon fluid vehicle. The particulate active substance contains an alkaloid ergotamine, pharmaceutically acceptable salts thereof, analogues thereof, or derivatives thereof. In some examples, the alkaloid ergotamine contains dihydroergotamine, such as dihydroergotamine mesylate and the hydrofluorocarbon fluid vehicle contains HFA 134a, HFA 227ea, or mixtures thereof. 1. An aerosol formulation containing a particulate active substance having a mass median aerodynamic diameter (MMAD) of less than 10 μm , suspended in a nonsolvent hydrofluorocarbon fluid vehicle at a concentration of 0.5% w/v or greater.2. An aerosol formulation according to claim 1 , wherein the particulate active substance has a MMAD of less than 5 μm.3. An aerosol formulation according to claim 1 , wherein the concentration of the active substance in the vehicle is from 0.5 to 1.5% w/v.4. An aerosol formulation according to claim 1 , wherein the fluid vehicle is either 1 claim 1 ,1 claim 1 ,1 claim 1 ,2-tetrafluoroethane (HFA 134a) or 1 claim 1 ,1 claim 1 ,1 claim 1 ,2 claim 1 ,3 claim 1 ,3 claim 1 ,3-heptafluoropropane (HFA 227ea) or a mixture thereof.5. An aerosol formulation according to claim 4 , wherein the active substance is a pharmaceutically or nutraceutically active substance which is suitable for ...

Microparticle Generation System

A system for fabricating microparticles useful for example in managing invasive species is provided. The system provides a nozzle for atomizing liquefied droplet material which is then suspended in a cyclonic separator receiving refrigerated gas until the droplets can solidify. In this way small droplets (less than 100 μm) can be readily fabricated in bulk without clumping and aggregating. 1. A microparticle generator assembly for forming solid microparticles from a solid bulk material comprising:a hopper providing heating element configured to melt the solid bulk material contained in the hopper into a liquid;a spray nozzle communicating with the hopper to receive the liquid and having an orifice with a diameter configured to atomize the liquid into liquid droplets having an average size of less than 100 μm; anda cyclonic separator receiving and suspending the droplets in a refrigerated gas until solidification as solid droplets.2. The assembly of wherein the cyclonic separator provides a chamber symmetric about a vertical axis and provides an average suspension of the droplets for at least three revolution about the axis.3. The assembly of wherein the cyclonic separator provides a chamber symmetric about a vertical axis and providing a tangential inlet near an upper surface for receiving the refrigerated gas and directing it along a tangent about the vertical axis into the chamber claim 1 , a centrally located exhaust port at the upper surface claim 1 , and a discharge port for discharging the solid droplets at a lower surface.4. The assembly of wherein the chamber is generally conical with an apex pointed downward to connect with the discharge port5. The assembly of wherein the nozzle is displaced from the axis to direct droplets into the tangentially received refrigerated gas.6. The assembly of further including an air pump drawing air from the exhaust port.7. The assembly of wherein the hopper further includes a mixer for mixing the liquid material within the ...

Formation and control of fluidic species

This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.

ELECTROHYDRODYNAMIC ATOMIZATION NOZZLE EMITTING A LIQUID SHEET

Embodiments for producing un-agglomerated, monodisperse droplets using a liquid sheet are provided. Nozzles with exit slit openings shape a spray liquid into a thin liquid sheet as the spray liquid exits from the slit opening. Stable multi-jet operation is achieved by including notches along the edge of the slit. The notches separate the liquid sheet into multiple jets to provide anchoring and stable multi-jet operation. In some embodiments, the liquid sheet electrospray techniques and nozzles described herein provide high mass throughput and versatile multiplexing spray systems while reducing the engineering effort and high manufacturing cost 1. A nozzle for electrohydrodynamic atomization , said nozzle comprising:an inner rod;an outer tube concentrically aligned with said inner rod;an annular channel defined between said inner rod and said outer tube, said annular channel forming a circular slit at a spray end of said nozzle; andat least one electrically chargeable notch located on at least one of said inner rod and said outer tube proximate said circular slit.2. A nozzle in accordance with claim 1 , wherein said inner rod comprises a central flow channel defined therethrough.3. A nozzle in accordance with claim 2 , wherein said central flow channel is configured to facilitate flow of at least one of a stabilizing gas and a stabilizing liquid therethrough.4. A nozzle in accordance with further comprising an outermost tube concentrically aligned with said inner rod and said outer tube such that an outer flow channel is defined between said outer tube and said outermost tube.5. A nozzle in accordance with claim 4 , further comprising at least one electrically chargeable notch located on said outermost tube.6. A nozzle in accordance with claim 1 , wherein said at least one electrically chargeable notch is located on only one of said inner rod and said outer tube.7. A nozzle in accordance with claim 1 , wherein said inner rod comprises a center piece at the spray end ...

Apparatus and method for liquid sample introduction

A method and apparatus for introducing droplets of liquid sample into an analysis device using a gas stream, the droplets being produced by the application of acoustic energy to a quantity of liquid sample. Acoustic energy may be applied to a quantity of liquid sample located on a solid surface of a sample support so as to eject a droplet of sample from the quantity of sample; the droplet of sample may be entrained in a gas stream; and the droplet of sample may be transported into the analysis device using the gas stream.

SILICA FINE POWDER AND USE THEREOF

Provided is an external additive for toner, which is suitable for producing a toner having excellent storage stability and chargeability. A silica fine powder suitable for being added to the external additive for toner is also provided. The silica fine powder has a specific surface area of 15 m/g or more and 90 m/g or less, a loose bulk density of 0.09 g/cmor more and 0.18 g/cmor less, a carbon content of 0.25 wt % or more and 0.90 wt % or less, and a hydrophobicity of 60% or more and 75% or less. It is preferable that a ratio (A)/(B) of the loose bulk density of the silica fine powder after surface treatment (A) to a loose bulk density of the silica fine powder before the surface treatment (B) be 1.05 or more and 1.60 or less. 1. A hydrophobized spherical silica fine powder , obtained by surface treating a spherical silica fine powder with hexamethyl disilazane , wherein the hydrophobized spherical silica fine powder has a specific surface area of 15 m/g or more and 90 m/g or less , a loose bulk density of 0.09 g/cmor more and 0.18 g/cmor less , a carbon content of 0.25 wt % or more and 0.90 wt % or less , and a hydrophobicity of 60% or more and 75% or less.2. The hydrophobized spherical silica fine powder according to claim 1 , wherein a ratio (A)/(B) of the loose bulk density of the hydrophobized spherical silica fine powder after the surface treatment (A) to a loose bulk density of the spherical silica fine powder before the surface treatment (B) is 1.05 or more and 1.60 or less.3. The hydrophobized spherical silica fine powder according to claim 1 , wherein the spherical silica fine powder is obtained by allowing metal silicon and oxygen to react with each other.4. An external additive for toner for electrostatic charge image development claim 1 , comprising the hydrophobized spherical silica fine powder according to .5. A silica fine powder having a specific surface area of 15 m/g or more and 90 m/g or less claim 1 , a loose bulk density of 0.09 g/cmor more ...

MICROPARTICLE PRODUCTION PROCESS AND APPARATUS

Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid. 1. An apparatus for producing solid polymeric microparticles , the apparatus comprising:a plurality of liquid droplet generators for forming liquid droplets of a first liquid, wherein the plurality of liquid droplet generators comprise at least one piezoelectric component operable to generate droplets; anda nozzle for forming a jet of a second liquid,wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid, and wherein, in use, the plurality ...

Method of coating metallic powder particles

A method and system for coating metallic powder particles is provided. The method includes: disposing an amount of metallic powder particulates within a fluidizing reactor; removing moisture adhered to the powder particles disposed within the reactor using a working gas; coating the powder particles disposed within the reactor using a precursor gas; and purging the precursor gas from the reactor using the working gas.

PROCESS FOR PREPARING A POLYAMIDE, A NYLON SALT TO BE USED THEREIN AND A PROCESS FOR MAKING THE SALT

The present invention relates to a process for preparing a polyamide, a polyamide material obtainable by the said process, a nylon salt to be used therein, and a process for making the nylon salt. The process for preparing the polyamide is a direct solid state polymerization process. The salt used herein is a granulate material, prepared by a process, comprising spraying an aqueous solution comprising a diamine and a dicarboxylic acid dissolved in an aqueous medium, or an aqueous slurry comprising a diammonium dicarboxylate salt dispersed in an aqueous medium directly obtained from such an aqueous solution, onto or in a fluidized bed of diammonium dicarboxylate salt particles, while evaporating the aqueous medium, thereby forming a granulate salt material. 1. Process for preparing a diammonium dicarboxylate granulate salt material comprising:spraying of an aqueous solution comprising a diamine, or a mixture of diamines, and a dicarboxylic acid, or a mixture of dicarboxylic acids dissolved in an aqueous medium, orspraying an aqueous slurry comprising a diammonium dicarboxylate salt dispersed in an aqueous medium directly obtained from an aqueous solution comprising a diamine and a dicarboxylic acid dissolved in an aqueous medium,wherein the aqueous solution or aqueous slurry is sprayed onto or in a fluidized bed of diammonium dicarboxylate salt particles, and wherein a preheated gaseous medium is led through the fluidized bed, while evaporating the aqueous medium, thereby forming the granulate salt material.2. Process according to claim 1 , wherein the aqueous medium comprises water and an alcohol claim 1 , or consists of water.3. Process according to claim 1 , wherein the aqueous solution or aqueous slurry has a salt concentration of at least 5 wt. % claim 1 , relative to the total weight of the solution or slurry.4. Process according to claim 1 , wherein the aqueous solution or aqueous slurry has a temperature of at least 35° C. claim 1 , the gaseous medium led ...

ATOMIZER NOZZLE, ATOMIZING DEVICE, METHOD FOR PRODUCING METAL POWDER, AND METAL POWDER

An atomizer nozzle includes: a molten metal nozzle extending in a vertical direction and which allows a molten metal to flow downward from a lower end thereof; and a gas nozzle including a chamber having an inner peripheral surface surrounding an outer periphery of the molten metal nozzle, a blow portion which introduces a gas to the chamber toward a circumferential direction of the molten metal nozzle, and a cover extending from the chamber to a position below the lower end of the molten metal nozzle while surrounding the molten metal nozzle, wherein the cover is provided with a tapered inner peripheral surface connected to the inner peripheral surface of the chamber and of which diameter is decreased as close to a lower end portion of the tapered inner peripheral surface. 1. An atomizer nozzle comprising:a molten metal nozzle extending in a vertical direction and which is configured to allow a molten metal to flow downward from a lower end of the molten metal nozzle; anda gas nozzle including a chamber having an inner peripheral surface surrounding an outer periphery of the molten metal nozzle, a blow portion which is configured to introduce a gas to the chamber toward a circumferential direction of the molten metal nozzle, and a cover extending from the chamber to a position below the lower end of the molten metal nozzle while surrounding the molten metal nozzle, wherein the cover is provided with a tapered inner peripheral surface which is connected to the inner peripheral surface of the chamber and of which diameter is decreased as close to a lower end portion of the tapered inner peripheral surface.2. The atomizer nozzle according to claim 1 , wherein the blow portion is formed so as to introduce the gas obliquely downward to the chamber.3. The atomizer nozzle according to claim 1 , wherein the cover is further provided with a diameter expansion surface which is connected to the lower end portion of the tapered inner peripheral surface and of which diameter is ...

MICRO ENCAPSULATION USING HIGH-VOLTAGE, LOW-CURRENT, HIGH FREQUENCY ALTERNATING-CURRENT SPRAY ATOMIZATION

Disclosed is a spray drying system and process for encapsulating a core material, such as a volatile flavor oil, within a carrier or wall material. The process is achieved by atomizing a liquid emulsion comprising the core material, the wall material, and a liquid solvent, applying a high-voltage, low-current, high frequency alternating-current charge or a high-voltage, low-current, low frequency alternating-current charge at the site of atomization, and drying the atomized emulsion into an encapsulated, free-flowing powder. Applying a high-voltage, low current alternating-current at the site of atomization allows the spray drying to be accomplished at significantly reduced temperatures, in particular, at inlet temperatures in the range of 25° C. to 150° C., and outlet temperatures in the range of 25° C. to 110° C. The low drying temperatures impart improvements in the resulting encapsulated powdered product, including better retention of volatile flavor components, a flavor profile comparable to that of the starting liquid formulation, and better hydration and dissolution in water-based applications. 1. A method for preparing an encapsulated product having a core component encapsulated within a wall material comprising the steps of:forming an emulsion by emulsifying at least one core material with at least one liquid solvent and at least one wall material;atomizing the emulsion into droplets using an atomizing gas and an atomizer connected to a high-voltage low-current alternating-current source that supplies a voltage charge to the droplets in the range of about 2 kV to about 200 kV;spraying the charged droplets into a drying chamber;drying the droplets in the drying chamber by contacting the droplets with a drying gas introduced into an inlet of the drying chamber, wherein the drying chamber has an inlet temperature set at about 25° C. to about 150° C. and an outlet temperature of about 25° C. to about 110° C.; andcollecting the dried droplets as the encapsulated ...

LIQUID FEEDING DEVICE FOR THE GENERATION OF DROPLETS

The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber. 1. Liquid feeding device for the generation of droplets , in particular for the use in a process line for the production of freeze-dried particles , witha droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, and wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.2. Liquid feeding device according to claim 1 , wherein the longitudinal axis of the liquid ...

Internal mix atomizing spray nozzle assembly, process and product

An internal mix atomizing spray nozzle assembly for preparing a spray-dried lipid and protein component-containing composition includes a fluid nozzle with a liquid flow passage having a liquid discharge opening directed into a mixing chamber, a spray tip comprising the mixing chamber and having at least one discharge orifice at a free end, an air supply system comprising an annular air flow passage arranged at least essentially coaxial to the liquid flow passage and having an annular air discharge opening directed into the mixing chamber. The annular air flow passage may be cylindrical with a constant cross section.

Method and device for generating droplets over a variable spectrum of particle sizes

A process for generating droplets with a modulatable droplet size distribution, comprises: making a stream of liquid strike a support with a given relative impact velocity; making said support vibrate at at least one vibration frequency; heating said support to a impact temperature such that the liquid film formed by the impact and made to vibrate is heated to a principal temperature to form in combination what are called principal droplets from said film; and transporting said droplets via a transfer/braking/sorting system to a liquid for precipitating the principal droplets, said transportation being carried out at a transportation temperature, all of these parameters, namely the relative impact velocity, the vibration frequency, the principal temperature and the transportation temperature allowing the droplet size of said formed principal droplets and the velocity of the latter to be modulated. A device allowing the process to be implemented is also provided.

Thermoplastic Polymer Particles

Provided are thermoplastic polymer particles having an aspect ratio of 1.00 or more and less than 1.05, and a roundness of 0.95 to 1.00. The thermoplastic polymer particles are formed from a thermoplastic polymer resin in a continuous matrix phase. The thermoplastic polymer particles show a peak cold crystallization temperature (Tcc) at a temperature between a glass transition temperature (Tg) and the melting point (Tm) in a differential scanning calorimetry (DSC) curve which is derived from temperature rise analysis at 10° C./min by differential scanning calorimetry.

External mixing pressurized two-fluid nozzle and a spray drying method

Disclosed herein is an external mixing pressurized two-fluid nozzle for atomising a liquid by means of liquid pressure and gas, comprising an inner feed liquid pipe ( 1 ) extending axially between an upstream end and a downstream end, having a feed liquid conduit ( 2 ), a feed liquid inlet ( 3 ) positioned at the upstream end and a feed orifice ( 4 ) positioned at the downstream end, and a co-axial first gas pipe ( 5 ) extending radially outside the inner feed liquid pipe ( 1 ) and forming a first gas conduit ( 6 ) between the first gas pipe ( 5 ) and the inner feed liquid pipe ( 1 ), the first gas pipe ( 5 ) having a gas outlet slit ( 7 ) positioned at the downstream end. Said external mixing two-fluid nozzle provides a swirling motion of the gas, which combined with a pressurized feed liquid enables the production of spray dried powder at industrially applicable capacities with low energy consumption and a small particle size.

PROCESS FOR MAKING SPRAY DRIED COMPOSITIONS AND SPRAY DRYING APPARATUS

The instant disclosure provides a process for making spray dried compositions and a spray drying apparatus. A relatively small, compound spray dryer is provide with an appropriately sized aspect ratio of height to diameter to allow sufficient drying time for typically sized spray dried dispersion particles intended for solid dosage form applications. The dryer is further designed to provide an amount of drying recirculation that serves to rapidly mix incoming hot drying gas to eliminate hot regions on the dryer walls. 1. A process for making a spray dried composition , comprising the steps:a) providing a spray solution comprising a solute and a solvent;b) providing a drying chamber having a chamber volume, an inlet end and an outlet end, the drying chamber including an atomizer located proximate the inlet end, the drying chamber having an exterior wall extending from the inlet end toward the outlet end and radially spaced apart from the atomizer;c) introducing a drying gas into the drying chamber;d) directing the spray solution to the atomizer at a feed rate of greater than 1 kg/hr, and atomizing the spray solution into the drying chamber to form droplets;e) removing the solvent from the droplets to form the composition;wherein at least a portion of the drying gas is recirculated within the drying chamber; and i) the drying chamber defines a height H between the inlet end and the outlet end, and a width W such that the drying chamber has an aspect ratio of H to W of at least 4;', 'ii) the drying chamber has a tapered cone portion proximate the outlet end, the exterior side wall of the tapered cone portion defining a cone angle 9 relative to a center axis Z extending between the inlet end and the outlet end of the drying chamber, the cone angle 9 being less than 40°:', {'sup': '3', 'iii) the ratio of a spray solution evaporation rate to the drying chamber volume is greater than 1 kJ/sec*m.'}], 'wherein'}2. The process of wherein chamber has an aspect ratio of at ...

SUBMICRON PARTICLE REMOVAL FROM GAS STREAMS

Disclosed are methods and systems for removing submicron particles from a gas stream, in particular from urea prilling off-gas, wherein a Venturi ejector is used. A method comprises contacting a gas stream containing submicron particles in a Venturi ejector with an injected high velocity scrubbing liquid to provide a pumping action, wherein the scrubbing liquid has an initial velocity of at least 2 m/s and wherein the ratio of scrubbing liquid and gas flow is between 0.0005 and 0.0015 (m/h)/(m/h). The disclosure also pertains to a prilling tower having a gas stream treatment system comprising a Venturi ejector at the top of the prilling tower, and to a method of modifying an existing prilling tower. 1. A method for removing submicron particles from a gas stream containing submicron particles said stream being off-gas from urea finishing , the method comprising: contacting the gas stream in a Venturi ejector with an injected high velocity scrubbing liquid to provide a pumping action , wherein the scrubbing liquid has an initial velocity of at least 25 m/s and wherein the ratio of scrubbing liquid and gas flow is between 0.0005 and 0.0015 (m/h)/m/h) ,whereby the method comprises treatment in two Venturi stages in series, wherein each of said two Venturi stages comprises a horizontally placed Venturi ejector, wherein said Venturi stages are placed above each other, and whereby the two Venturi stages are connected by a scrubbing column.2. The method of claim 1 , wherein the gas stream is the off-gas from a urea granulator.3. The method of wherein the gas stream is the off-gas from a urea prilling tower.4. The method of wherein the residence time between the first and the downstream second Venturi ejector is at least 0.4 s.5. The method of claim 1 , wherein the gas stream contains a concentration of submicron particles greater than 20 mg/Nm.6. The method of wherein the Venturi ejector comprises a nozzle positioned for spraying scrubbing liquid in a direction parallel ...

MONO DISPERSE POLYMER NANOPARTICLES, FUNCTIONALIZED NANOPARTICLES AND CONTROLLED FORMATION METHOD

A method produces polymer nanoparticles. Polymer solution is sprayed through a nozzle toward a collector. An electric field is created at the nozzle, such as by a voltage is applied to the nozzle to create the electric field. The voltage applied to the nozzle is from ˜10 (Kilovolt) to ˜30 (Kilovolt), distance from nozzle tip to collector is from ˜1 (centimeter) to ˜10 (centimeter) and the polymer concentration from ˜0.01% to ˜0.5% w/w. Preferably a grounded liquid collectors is used. The invention provides biocompatible monodisperse polymer nanoparticles having a size of less than ˜300 nm, preferably less than ˜150 nm. Payloads can be associated, and maintain efficacy, including more than one payload such as therapeutic agents and diagnostic agents on the same particles. Preferred particles are poly(methyl methacrylate) (PMMA-COOH) or acrylate analogues. 1. A method for forming polymer nanoparticles , the method comprising:spraying polymer solution through a nozzle toward a collector; andapplying an electric field around the nozzle while spraying, wherein a distance from nozzle tip to collector is from ˜1 (centimeter) to ˜10 (centimeter) and the polymer concentration from ˜0.01% to ˜0.5% w/w.2. The method of claim 1 , wherein the electric field is created by applying voltage to the nozzle; wherein the voltage is from ˜10 (Kilovolt) to ˜30 (Kilovolt).3. The method of claim 1 , wherein the collector comprises a liquid.4. The method of claim 3 , wherein the liquid comprises grounded de-ionized water.5. The method of claim 1 , wherein the polymer is a polymer comprising a polymer having a molecular weight of at least 5 kDa and sufficient viscoelasticity to transform into nanoparticles.6. The method of claim 1 , wherein the polymer comprises PMMA-COOH or acrylate analogues thereof.7. The method of claim 1 , wherein the acryl ate analogue is selected from poly(ethyl acrylate) claim 1 , Poly(butylacrylate) claim 1 , poly(methyl acrylate) claim 1 , copolymers of neutral ...

FLUIDIZED BED SPRAY DRYER SYSTEM

A fluidized bed spray drying system for drying liquid into powder including an elongated drying chamber, a spray nozzle assembly at an upper end of the drying chamber and a powder collection chamber at a lower end of the drying chamber. A drying gas inlet is provided in the powder collection chamber and a drying gas outlet is provided at an upper end of the drying chamber. A plurality of cylindrical filter elements at the upper end of the drying chamber are in communication with the exhaust gas outlet for filtering drying gas borne powder from drying gas exiting the drying chamber. 1. A fluidized bed spray drying system for drying liquid into powder comprising:an elongated body supported in an upright position;a closure arrangement at opposite upper and lower ends of the elongated body for forming a drying chamber within said elongated body;a liner disposed within said elongated body in spaced relation to an inner wall surface of the elongated body for defining an internal drying zone with said elongated body;a spray nozzle assembly supported in one of the closure arrangements;said spray nozzle assembly including a nozzle body having a liquid inlet for coupling to a supply of liquid, a discharge spray tip assembly at a downstream end for directing liquid to be dried into said drying zone and an electrode for coupling to an electrical source for electrically charging liquid passing through said spray nozzle assembly into said drying zone;said lower end closure arrangement including a powder collection chamber for collecting powder dried in said drying zone;said powder collection chamber having a drying gas inlet for introducing drying gas into said drying chamber for drying liquid directed into the drying chamber into powder;said upper end closure arrangement having a plurality of filter elements communicating with an exhaust gas outlet for filtering drying gas borne powder from drying gas exiting the drying chamber through said filter elements and the exhaust gas ...

ATOMIZER, SPRAY-DRYING APPARATUS, AND METHOD FOR MANUFACTURING COMPOSITE PARTICLES

A nozzle part dropping a slurry and a rotary disk centrifugally spraying the slurry to be dropped from the nozzle part are included. The rotary disk includes a plurality of grooves stretching in a radiation direction at least in a periphery part of a surface on which the slurry is sprayed. 1. An atomizer comprising:a nozzle part dropping a slurry; anda rotary disk centrifugally spraying the slurry to be dropped from the nozzle part,wherein the rotary disk includes a plurality of grooves stretching in a radiation direction at least in a periphery part of a surface on which the slurry is sprayed.2. The atomizer according to claim 1 , wherein the rotary disk has a disk-like shape and includes an annular inclined surface inclined in a radiation direction claim 1 , the inclined surface being formed around a central portion of the disk-like shape and having a predetermined angle relative to a horizontal direction.3. The atomizer according to claim 2 , wherein the rotary disk includes a liquid reservoir part reserving the slurry at least around a central portion of an upper surface of the disk-like shape.4. The atomizer according to claim 1 , wherein a surface which has the plurality of grooves is on an upper surface of the rotary disk.5. The atomizer according to claim 1 , wherein a surface which has the plurality of grooves is on a lower surface of the rotary disk claim 1 , andthe rotary disk includes twenty or more holes circumferentially arranged and penetrating from an upper surface of the rotary disk to the lower surface.6. The atomizer according to claim 1 , wherein each of the grooves has a width equal to or more than 50 μm and equal to or less than 5 mm and has a depth equal to or more than 50 μm and equal to or less than 5 mm.7. The atomizer according to claim 1 , wherein a linear velocity of the slurry to be dropped from the nozzle part is equal to or more than 50 m/min.8. The atomizer according to claim 1 , wherein a/b is equal to or more than 0.8 claim 1 , ...

Ultrahigh efficiency spray drying apparatus and process

The disclosure relates to ultrahigh efficiency spray drying systems and processes, utilizing induction of localized turbulence in a drying fluid flow stream to produce spray dried product, having particular utility for low temperature spray drying operations. In a specific implementation, a method of processing a spray dryable liquid composition to form a spray dried product includes the steps of: generating a spray of the spray dryable liquid composition; contacting the spray of spray dryable liquid composition in a spray drying contact zone with a stream of primary drying fluid; injecting pressurized secondary drying fluid into the stream of primary drying fluid in the spray drying contact zone at multiple loci thereof to provide localized turbulence at said multiple loci; and recovering the spray dried product from the spray drying contact zone. Systems of the present disclosure are effective in achieving high-rate production of dry powder spray dried products, with substantially reduced capital equipment costs, energy requirements, and operating expenditures.

Granules comprising an active substance

The present invention relates to granules comprising an active substance, obtained by spray-drying an emulsion comprising said active substance, solid particles, water and a water-soluble biopolymer having a molecular weight below 100 KDa. The invention further relates to a process for obtaining such granules and to products containing them.

METHOD OF SPRAY-DRYING AND APPARATUS FOR SPRAY-DRYING

Method of spray-drying a high-viscosity fluid, e.g. comprising a food product. The method comprises providing a nozzle plate wherein at least one nozzle is provided, said nozzle plate having an inner main surface and an outer main surface. The method comprises providing the high-viscosity fluid in a reservoir that is in fluidum connection with the at least one nozzle. The method comprises pressurizing the high-viscosity fluid in the reservoir, wherein the fluid flows, as a result of said pressurizing, towards the nozzle plate, thus creating a pressure difference over the at least one nozzle so that the fluid flows out of the at least one nozzle, thereby passing the outer main surface after passing the inner main surface. A cross-sectional area of the at least one nozzle in the inner main surface exceeds a cross-sectional area of the at least one nozzle in the outer main surface. 1. Method of spray-drying a high-viscosity fluid using a spraying device , the method comprising:providing a nozzle plate wherein at least one nozzle is provided, said nozzle plate having an inner main surface and an outer main surface, the at least one nozzle extending through the nozzle plate from the inner main surface to the outer main surface;providing the high-viscosity fluid in a reservoir that is in fluidum connection with the at least one nozzle;pressurizing the high-viscosity fluid in the reservoir, wherein the fluid flows, as a result of said pressurizing, towards the nozzle plate, thus creating a pressure difference over the at least one nozzle so that the fluid flows out of the at least one nozzle, thereby passing the outer main surface after passing the inner main surface; wherein the fluid flowing out of the nozzle forms a jet that breaks up into droplets; andat least partially drying the droplets in a drying medium, such as air, to become particles;wherein a cross-sectional area of the at least one nozzle in the inner main surface exceeds a cross-sectional area of the at ...

METHOD FOR PRODUCING PARTICLES AND APPARATUS FOR PRODUCING PARTICLES

To provide a method for producing particles, which contains: bringing a compressive fluid and a pressure plastic material into contact with each other using a multistage split flow micromixer, to thereby produce a melt of the pressure plastic material, in which the compressive fluid is dissolved; and jetting the melt of the pressure plastic material, to form particles, wherein the pressure plastic material is a resin having a carbonyl structure —C(═O)—, and wherein a viscosity of the melt is 500 mPa·s or lower, as measured under temperature and pressure conditions at the time of the jetting the melt of the pressure plastic material. 1. A method for producing particles , the method comprising:bringing a compressive fluid and a pressure plastic material into contact with each other using a multistage split flow micromixer to produce a melt of the pressure plastic material, in which the compressive fluid is dissolved; andjetting the melt of the pressure plastic material to form particles,whereinthe pressure plastic material is a resin comprising a carbonyl structure —C(═O)—, andthe melt has a viscosity of 500 mPa·s or lower, as measured under temperature and pressure conditions at the time of the jetting.2. The method according to claim 1 , wherein the multistage split flow micromixer comprises:a compressive fluid split section configured to split and guide the compressive fluid into a plurality of circular tube flow channels, after the compressive fluid is flown into the multistage split flow micromixer;a double tube mixing section comprising a double tube structure composed of an inner tube into which the compressive fluid is flown, and an outer tube surrounding the inner tube, into which the pressure plastic material is flown, where a number of the double tube mixing section is identical to a split number of the compressive fluid split section in a downstream area from the compressive fluid split section, and is configured to mix the compressive fluid and the ...

DROPLETIZATION APPARATUS WITH CATCHING DEVICE

A dropletization apparatus for producing granules from a melt, such as a melt for producing pharmacological granules, or a low-viscosity plastic melt of polyamides or copolyamides. The apparatus can have a caster nozzle which imparts an oscillation to the melt. Upon forming granule/droplets, the melt material can traverse an adjustable fall zone to become granules. The granule/droplets and/or granules can impact a catching device comprising a truncated cone and enter a cooling fluid. Granules can then be separated from the cooling fluid and removed for further processing. 2. The dropletization apparatus of claim 1 , wherein the guiding slits run in the longitudinal direction and comprise a guide surface which has a flatter angle compared to the angle of the truncated cone in the region.3. The dropletization apparatus of claim 1 , wherein the guiding slits and/or the peripheral region of the lateral surface is/are immersed in the cooling fluid bath.4. The dropletization apparatus of claim 1 , wherein the guiding slits are circumferentially disposed around the peripheral region of the lateral surface.5. The dropletization apparatus of claim 1 , wherein the guiding slits are circumferentially disposed at uniform angular distances.6. The dropletization apparatus of claim 1 , wherein there are 3 to 16 guiding slits.7. The dropletization apparatus of claim 1 , wherein there are 4 guiding slits placed ninety degrees apart from one another.8. The dropletization apparatus of claim 1 , wherein the catching device is adjustable in two axes.9. The dropletization apparatus of claim 1 , wherein the truncated cone comprises a curved lateral surface.10. The dropletization apparatus of claim 9 , wherein the curved lateral surface is in the shape of an ellipsoid.11. The dropletization apparatus of claim 10 , wherein the curved lateral surface is in the shape of an ellipsoid which is concavely curved.12. The dropletization apparatus of claim 1 , wherein the catching device is ...

SPRAY DRIER ASSEMBLY FOR AUTOMATED SPRAY DRYING

A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device adapted to couple with a spray drier assembly. The assembly may include an enclosure mounted to a frame. The assembly may receive a flow of drying gas which is directed by the enclosure shape towards a spray drying head mounted within the enclosure to the frame. Flows of a liquid sample may be further received by the head, which aerosolizes the liquid sample. Aerosolized liquid sample and drying air may be mixed within a drying chamber of the enclosure to produce dried sample and humid air. The dried sample and humid air may also be separated in a collection chamber of the enclosure, with the humid air exhausted from the enclosure. 1. A spray drier assembly , comprising:an enclosure having a first end and a second end, the enclosure including a drying gas inlet adjacent to the first end adapted to receive a flow of drying gas;a spray drying head within the spray dryer assembly enclosure and positioned within the path of the flow of drying gas, wherein the spray drying head is adapted to receive a flow of aerosolizing gas and a flow of liquid sample, output an aerosolized flow of liquid sample, and expose the aerosolized flow of liquid sample to the drying gas passing therethrough;the spray drier assembly enclosure further including:a drying chamber positioned between the spray drying head and the second end of the enclosure, the drying chamber adapted to receive the aerosolized flow of liquid sample and drying gas and separate the aerosolized flow of liquid sample into a dried powder suspended in humid air; anda collection chamber including a first filter adapted to separate the dried powder from the humid air and an exhaust port allowing the humid air to exit the second end of the enclosure; anda second filter, disposed between the drying gas inlet and the spray drying head.2. The spray drier assembly of claim 1 , further ...

PROCESS FOR MAKING A GRANULE OR POWDER

Process for making a powder or granule containing