04-06-2020 дата публикации
Номер: US20200171036A1
Принадлежит:
Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water. 1. A pharmaceutical composition comprising Ibrutinib , a salt , prodrug , or metabolite thereof , microcrystalline cellulose , carboxymethylcellulose sodium , hydroxypropylmethylcellulose , citric acid monohydrate , disodium hydrogen phosphate , sucralose , sodium methyl parahydroxybenzoate , sodium ethyl parahydroxybenzoate , concentrated hydrochloric acid , sodium hydroxide , and water.2. The pharmaceutical composition of claim 1 , comprising about 30 to about 80 mg/mL of Ibrutinib.3. The pharmaceutical composition of claim 1 , comprising about 30 to about 50 mg/mL of Ibrutinib.4. The pharmaceutical composition of claim 1 , comprising about 60 to about 80 mg/mL of Ibrutinib.5. The pharmaceutical composition of claim 1 , ...
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