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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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05-01-2012 дата публикации

Apparatus and method for continuous production of materials

Номер: US20120001356A1

Автор: Chih-Hung Chang, Hyungdae Jin

Принадлежит: Oregon State Board of Higher Education

Embodiments of a continuous-flow injection reactor and a method for continuous material synthesis are disclosed. The reactor includes a mixing zone unit and a residence time unit removably coupled to the mixing zone unit. The mixing zone unit includes at least one top inlet, a side inlet, and a bottom inlet. An injection tube, or plurality of injection tubes, is inserted through the top inlet and extends past the side inlet while terminating above the bottom outlet. A first reactant solution flows in through the side inlet, and a second reactant solution flows in through the injection tube(s). With reference to nanoparticle synthesis, the reactant solutions combine in a mixing zone and form nucleated nanoparticles. The nucleated nanoparticles flow through the residence time unit. The residence time unit may be a single conduit, or it may include an outer housing and a plurality of inner tubes within the outer housing.

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Номер записи: 1

12-01-2012 дата публикации

Multilayer Hydrodynamic Sheath Flow Structure

Номер: US20120009025A1

Автор: Bernard Bunner, John R. Gilbert, Manish Deshpande

Принадлежит: Cytonome ST LLC

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

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Номер записи: 2

08-03-2012 дата публикации

Process for treating and/or forming a non-newtonian fluid using microchannel process technology

Номер: US20120058063A1

Автор: Anna Lee Tonkovich, David Kilanowski, Eric Daymo, Ravi Arora

Принадлежит: Individual

The disclosed invention relates to a process, comprising: conducting unit operations in at least two process zones in a process microchannel to treat and/or form a non-Newtonian fluid, a different unit operation being conducted in each process zone; and applying an effective amount of shear stress to the non-Newtonian fluid to reduce the viscosity of the non-Newtonian fluid in each process zone, the average shear rate in one process zone differing from the average shear rate in another process zone by a factor of at least about 1.2.

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Номер записи: 3

29-03-2012 дата публикации

Thermal Microvalves

Номер: US20120077231A1

Автор: Brian N. Johnson, Mark A. Burns, Michael Chen

Принадлежит: University of Michigan

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

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Номер записи: 4

29-11-2012 дата публикации

Microchemical nanofactories

Номер: US20120298037A1

Автор: Brian Kevin Paul, Chih-Hung Chang, Vincent Thomas Remcho

Принадлежит: Oregon State Board of Higher Education, State University

Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.

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Номер записи: 5

06-12-2012 дата публикации

Microprocessing for preparing a polycondensate

Номер: US20120309956A1

Автор: Bruno Frederic Stengel, Christof Franz Kuesters, J. Brandner, W. Benzinger

Принадлежит: Cargill Inc

The present invention relates to a process for preparing polydextrose by using a microdevice. It further relates to the use of a microdevice for the polycondesation reactions.

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Номер записи: 6

14-03-2013 дата публикации

Methods and systems for forming boronic acids and intermediates thereof

Номер: US20130066115A1

Автор: Catherine A. MENNING, D. Wayne Blaylock, Mark V. M. Emonds

Принадлежит: DOW AGROSCIENCES LLC

Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.

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Номер записи: 7

06-06-2013 дата публикации

Device for the synthesis of radio-labeled compounds

Номер: US20130144052A1

Автор: Marco Mueller

Принадлежит: ABX advanced biochemical compounds GmbH

The invention relates to a device for the synthesis of radio-labeled compounds, which comprises a reaction vessel for reacting a precursor compound having protective groups with a radioactive isotope to obtain a first reaction product; a first cartridge for hydrolyzing the protective groups of the first reaction product to obtain a second reaction product; and a second cartridge for purifying the second reaction product, wherein the reaction vessel, the first cartridge, and the second cartridge are connected to each other via pipelines. Here it is provided that the first cartridge contains 801 to 1200 mg of a solid carrier and/or the reaction vessel is a reaction vessel made of a temperature-resistant plastic with the plastic having a temperature resistance of at least 120° C.

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Номер записи: 8

03-10-2013 дата публикации

Microfluidic component, reactor comprising a plurality of such components, and method for producing same

Номер: US20130255822A1

Автор: Martin Wichert, Silvio Kraus

Принадлежит: INSTITUT FUER MIKROTECHNIK MAINZ GMBH

A microfluidic component made of a metal sheet having a structure which includes a closed fluid line and which is formed of a structured surface of a first section of the metal sheet and an adjoining structured or unstructured surface of a second section of the metal sheet, wherein the metal sheet is folded such that the sections integrally connected to each other are located on top of each other in a surface-parallel manner. The metal sheet further includes at least one third section having a contoured edge and is moreover folded such that the third section is also supported in a surface-parallel manner and the contoured edge forms a first wall section and the adjoining structured or unstructured surface of the first or second section forms a second wall section of an open fluid line. A microfluidic reactor comprising a plurality of such microfluidic components and a method for producing such components.

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Номер записи: 9

07-01-2016 дата публикации

APPARATUS FOR MANUFACTURING PARTICLES AND METHOD FOR MANUFACTURING PARTICLES USING THE SAME

Номер: US20160001253A1

Автор: CHOI Gyeong Rye, HONG Jong Pal

Принадлежит:

Apparatus for manufacturing particles has at least one reactor and a method for manufacturing particles using the same. A first reactor has a hollow main body extending in the lengthwise direction, first and second raw material inlets formed at the one side end of the main body, a reactant outlet formed at the other side end of the main body, and a mixer formed inside the main body to mix materials fed from the first and second raw material inlets. A second reactor of the apparatus connected to one side of the first reactor has a non-revolving hollow cylinder extending in the lengthwise direction, a revolving body extending in the lengthwise direction, a driver portion, a reactant inlet formed on the outer circumference at one side end of the cylinder and connected to the reactant outlet of the first reactor. 16-. (canceled)7. Apparatus for manufacturing particles , comprising:at least one first reactor comprising a hollow main body extending in a lengthwise direction, first and second raw material inlets formed at a first side end of the hollow main body to open into the hollow main body, a reactant outlet formed at a second side end of the hollow main body to open into the hollow main body, and a mixer formed inside of the hollow main body to mix materials fed from the first and second raw material inlets;a second reactor, connected to one side of said at least one first reactor, comprises a non-revolving hollow cylinder extending in a lengthwise direction, a revolving body extending in a lengthwise direction and configured in the second reactor to separate from an inner wall of the non-revolving hollow cylinder, a driver portion connected to one side end of the revolving body to rotate the revolving body, a reactant inlet formed on an outer circumference at a first side end of the non-revolving hollow cylinder in a lengthwise direction of the non-revolving hollow cylinder to open into the non-revolving hollow cylinder and connected to the reactant outlet of said ...

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Номер записи: 10

04-01-2018 дата публикации

APPARATUS FOR MASS PRODUCING A MONODISPERSE MICROBUBBLE AGENT

Номер: US20180001282A1

Автор: de Castro Hernández Elena, Gordillo Arias de Saveedra José Manuel, Lohse Detlof, van Hoeve Willem, Versluis Andreas Michael

Принадлежит:

An apparatus for mass producing monodisperse microbubbles includes a microfluidic flow focusing device, which includes a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction, a continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction, and a bubble formation channel having an inlet disposed at the flow focusing junction. The configuration of the flow focusing junction is such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel. 1. An apparatus for mass producing monodisperse microbubbles , comprising: a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction;', 'at least one continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction; and', 'a bubble formation channel having an inlet disposed at the flow focusing junction,, 'at least one microfluidic flow focusing device including 'wherein said bubble formation channel has a length that is much greater than its hydraulic diameter by a factor of at least ten.', 'the configuration of the flow focusing junction being such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel,'}2. The apparatus according to claim 1 , further comprising:a source ...

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Номер записи: 11

08-01-2015 дата публикации

Modular flow reactor

Номер: US20150010445A1

Автор: Charalampos MAKATSORIS, Leonid Paramonov, Rakan Alsharif

Принадлежит: BRUNEL UNIVERSITY, Brunel University London

A modular flow reactor is formed of a plurality of modules, wherein each module comprises a body having at least one conduit passing therethrough, and wherein a plurality of said modules are aligned along a longitudinal axis such that said conduits of said modules are aligned to form a passage for fluid, wherein each module has a length along said longitudinal axis which is less than the length of the module perpendicular to the longitudinal axis. The modules are “slices” rather than “tubes” and a plurality of said modules can be aligned linearly so that the conduits form a tube.

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Номер записи: 12

11-01-2018 дата публикации

System and Method for Controlled Manufacturing of Mono-Disperse Microbubbles

Номер: US20180008951A1

Автор: HOGERVORST Richard Petrus, van Hoeve Willem

Принадлежит:

The present invention is related to a system and method for controlled manufacturing of mono-disperse microbubbles. According to the invention, the mono-disperse nature of the collection of generated microbubbles can be improved by releasing the pressurized gaseous medium used in the system using release valve units. This further allows the system to be embodied as a portable system. In turn, the operator of an ultrasound imaging apparatus may use the system according to the invention to generate microbubbles on a patient-by-patient basis. 1. A system for controlled manufacturing of microbubbles , comprising:a microbubble generation unit having a first inlet for receiving a dispersed phase fluid, a second inlet for receiving a continuous phase fluid, and a bubble formation channel in which microbubbles are generated using the received dispersed phase fluid and the received continuous phase fluid, wherein the bubble formation channel has a width in the range of 15-35 micrometer, and a height in the range of 10-30 micrometer;a liquid pressurization unit having an inlet for receiving a second pressure regulated gaseous medium from a source of said second pressure regulated gaseous medium and being configured for outputting a flow of a pressurized liquid to the second inlet of the microbubble generation unit in dependence of a flow and/or pressure of the received second pressure regulated gaseous medium, wherein the first inlet of the microbubble generation unit is connected to a source of a first pressure regulated gaseous medium;a first release valve unit arranged in between the source of the first pressure regulated gaseous medium and the first inlet of the microbubble generation unit and being configured for releasing the first pressure regulated gaseous medium;a second release valve unit arranged in between the source of the second pressure regulated gaseous medium and the inlet of the liquid pressurization unit and being configured for releasing the second ...

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Номер записи: 13

19-01-2017 дата публикации

Microchannel processor

Номер: US20170014795A1

Автор: Andreas Munding, Anna Lee Tonkovich, Barry L. Yang, Bin Yang, Jeffrey Marco, Jennifer Marco, Kai Tod Paul Jarosch, Paul Neagle, Ravi Arora, Sara Kampfe, Thomas Yuschak

Принадлежит: Velocys Inc

This invention relates to an apparatus, comprising: a plurality of plates in a stack defining at least one process layer and at least one heat exchange layer, each plate having a peripheral edge, the peripheral edge of each plate being welded to the peripheral edge of the next adjacent plate to provide a perimeter seal for the stack, the ratio of the average surface area of each of the adjacent plates to the average penetration of the weld between the adjacent plates being at least about 100 cm 2 /mm. The stack may be used as the core assembly for a microchannel processor. The microchannel processor may be used for conducting one or more unit operations, including chemical reactions such as SMR reactions.

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Номер записи: 14

25-01-2018 дата публикации

Disconnector Device

Номер: US20180021750A1

Автор: Dumont Philippe

Принадлежит: GE HEALTHCARE LIMITED

The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator. 21. The automated radiosynthesis device as defined in claim , wherein said plurality of connectors is selected from the group comprising fasteners , and fluidic connectors.3. The automated radiosynthesis device as defined in claim 2 , wherein said fluidic connectors are selected from the group comprising push-on type connectors luer slip connectors and luer screw connectors.41. The automated radiosynthesis device as defined in claim claim 2 , wherein said disposable kit is suitable for the synthesis of a radiotracer compound.5. The automated radiosynthesis device as defined in claim 4 , wherein said radiotracer compound is a positron-emission tomography (PET) tracer.6. The automated radiosynthesis device as defined in claim 5 , wherein said radiotracer compound is an F-labelled PET tracer.71. The automated radiosynthesis device as defined in claim claim 5 , wherein said disposable kit is a single-use cassette.81. The automated radiosynthesis device as defined in claim claim 5 , wherein said plurality of actuators is selected from the group comprising rotatable arms for stopcocks of valves claim 5 , linear actuators claim 5 , arms that press onto reagent vials and pinch valves.91. The automated radiosynthesis device as defined in claim claim 5 , wherein said moving parts of said disposable kit are selected from the group comprising reagent vials claim 5 , syringes and valves.101. The automated radiosynthesis device as defined in claim claim 5 , wherein said control unit includes software comprising instructions for a particular radiosynthesis method to be carried out on said disposable kit attached to said ...

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Номер записи: 15

25-01-2018 дата публикации

System and method for rehydrating powder and delivering the rehydrated powderto a reactor

Номер: US20180021772A1

Автор: Alexander PEKIN, Ira Naot, Molly K. MULLIGAN, Yair FEUCHTWANGER, Yair GLICK

Принадлежит: Spacepharma SA

A closed system for rehydrating powder and delivering the rehydrated powder to a reactor, may include a liquid reservoir for containing liquid; a syringe configured to contain powder to be rehydrated; a reactor; a controller for controlling operation of the syringe; and a conduit fluidically linking the liquid reservoir to a port of the syringe, fluidically linking the port to the reactor. The controller is configured to operate the syringe so as to draw liquid from the liquid reservoir into the syringe and rehydrate the powder, or to drive the rehydrated powder into the reactor.

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Номер записи: 16

25-01-2018 дата публикации

REVERSE-PHASE POLYMERISATION PROCESS INCORPORATING A MICROFLUIDIC DEVICE

Номер: US20180022837A1

Автор: FONSECA ZEPEDA Gabriela Eugenia, HASCHICK Robert, HOLTZE Christian, JELICIC Aleksandra, RECKMANN Anna, STRUBEL Bernd

Принадлежит: BASF SE

Disclosed herein is a polymerization process involving the steps of generating monomer micro-volumes in a microfluidic device, feeding the monomer micro-volumes through the at least one first microfluidic channel towards a monomer feed point at which the monomer micro-volumes enter into or onto a volume of a non-aqueous liquid and form aqueous monomer droplets, allowing the aqueous monomer droplets to flow towards a polymer bead discharge point, initiating polymerisation of the aqueous monomer droplets to form polymerising beads, removing a suspension of the polymer beads in the non-aqueous liquid from the vessel at the polymer bead discharge point, and recovering water soluble or water swellable polymer beads from the suspension. The present disclosure also includes an apparatus for performing the polymerization process and water soluble or water swellable polymer beads obtained by the polymerization process. 1. A reverse-phase suspension polymerisation process for the manufacture of polymer beads comprising forming aqueous monomer droplets of an aqueous solution comprising water-soluble ethylenically unsaturated monomer or monomer blend and polymerising the monomer or monomer blend , to form polymer beads while suspended in a non-aqueous liquid , and recovering polymer beads , the process comprising:providing in a vessel a volume of non-aqueous liquid wherein the volume of non-aqueous liquid extends between at least one polymer bead discharge point and at least one monomer feed point,generating monomer micro-volumes in at least one microfluidic device, said monomer micro-volumes being separated by non-aqueous liquid in at least one first microfluidic channel,feeding the monomer micro-volumes through the at least one first microfluidic channel towards the at least one monomer feed point at which the monomer micro-volumes enter into or onto the volume of non-aqueous liquid and form aqueous monomer droplets,allowing the aqueous monomer droplets to flow towards the ...

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Номер записи: 17

24-01-2019 дата публикации

REACTOR SYSTEM FOR HIGH THROUGHPUT APPLICATIONS

Номер: US20190022619A1

Автор: Hartog Benno, Moonen Roelandus Hendrikus Wilhelmus

Принадлежит: AVANTIUM TECHNOLOGIES B.V.

A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel. 120.-. (canceled)21. A reactor system for high throughput applications , which reactor system comprises: a flow-through reactor, said flow-through reactor comprising a reactor inlet and a reactor outlet, which flow-through reactor is adapted to accommodate a chemical reaction,', 'a reactor feed line, which reactor feed line has a first end and a second end, said second end being connected to the reactor inlet of the flow-through reactor, said reactor feed line being adapted to supply a fluid to the flow-through reactor, and', 'a reactor effluent line, which reactor effluent line has a first end, which first end is connected to the reactor outlet of the flow-through reactor, said reactor effluent line being adapted to discharge reactor effluent from the flow-through reactor,, 'a plurality of reactor assemblies, each reactor assembly comprisinga fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, anda flow path controller which is adapted to transfer said pressurized fluid from the fluid source to the reactor assemblies, so that said ...

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Номер записи: 18

04-02-2016 дата публикации

MICROPROCESSING FOR PREPARING A POLYCONDENSATE

Номер: US20160032022A1

Автор: BENZINGER Walther, BRANDNER Jurgen J., KÜSTERS Christof Franz, Stengel Bruno Frederic

Принадлежит:

The present invention relates to a process for preparing polydextrose by using a microdevice. It further relates to the use of a microdevice for the polycondesation reactions. 114-. (canceled)15. An arrangement of microdevices for the following process for preparing polydextrose.a) providing glucose;b) adding an acidifying catalyst to the glucose to provide an acidic composition;c) injecting the acidic composition through a microdevice; andd) collecting polydextrose,wherein the arrangement allows a single-pass-through of the composition of step c) a re-mix of the polydextrose of step d) with the acidic composition of step c) for a multi-pass-through, or a complete multi-pass-through for the acidic composition. The present invention relates to a process for preparing polydextrose, by using microdevices.In order to continually improve physical standards of living for greater number of people, it is necessary to achieve more results with fewer resources. Therefore there is the tendency towards building and manufacturing smaller-scale products due to the desire for size efficiency. Most recently, scientists have learned that not only electronic devices, but also mechanical devices, may be miniaturized and batch-fabricated, promising the same benefits to the mechanical world as integrated circuit technology has given to the electronic world.Acid-catalysed polymerisation of saccharides is a well-known phenomenon which is described in numerous general articles, books and patents.Polydextrose is commercially available and all of these polydextrose products include a variety of residual compounds such as glucose, sorbitol, citric acid and other compounds which contribute to the taste, colour, and caloric value. Low molecular weight compounds such as 1,6-anhydroglucose and 5-hydroxymethylfurfural contribute a bitter taste and off-flavour.U.S. Pat. No. 3,766,165 discloses that polymers useful as low-calorie food ingredients can be prepared by heating dextrose or maltose, ...

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Номер записи: 19

17-02-2022 дата публикации

APPARATUS, SYSTEMS, AND METHODS FOR CONTINUOUS MANUFACTURING OF NANOMATERIALS AND HIGH PURITY CHEMICALS

Номер: US20220047510A1

Автор: Fisher Robert Joseph, PANAGIOTOU Thomai

Принадлежит:

A method for continuously processing at least two liquid feed streams is provided. A system for continuously processing at least two liquid feed streams is also provided. 158-. (canceled)59. A method for continuously processing at least two liquid feed streams , comprising:pumping a first feed stream to a mixer;flowing a second feed stream to the mixer without pumping the second feed stream to the mixture;mixing the first and second feed streams to achieve a substantially homogeneous mixture; andpumping the substantially homogeneous mixture to a high pressure pump,wherein mixing the first and second feed streams to achieve the substantially homogenous mixture includes mixing the first and second feed streams with the mixer at a location that is upstream of the high pressure pump and upstream of a component arranged between the mixer and the high pressure pump, andwherein the component is selected from one of the following: a conduit, a tank, a valve, a pump, a filter, a screen, a sensor, or a port.60. The method of claim 59 , further comprising:pressurizing the substantially homogeneous mixture within the high pressure pump to an elevated pressure; anddelivering the substantially homogeneous mixture to a microreactor downstream from the high pressure pump to cause the first and second feed streams to interact within the microreactor at a nanoscale level.61. The method of claim 60 , wherein:pressurizing the substantially homogeneous mixture within the high pressure pump includes pressurizing the substantially homogeneous mixture to an elevated pressure of at least 35 MPa; anddelivering the substantially homogeneous mixture to the microreactor includes delivering the substantially homogeneous mixture to a microreactor having a minimum channel dimension of equal to or less than 500 microns.62. The method of claim 60 , wherein:the first feed stream includes a first reactant;the second feed stream includes a second reactant; andthe method further comprises adjusting ...

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Номер записи: 20

11-02-2016 дата публикации

Microchannel Apparatus and Methods of Conducting Unit Operations With Disrupted Flow

Номер: US20160038904A1

Автор: Arora Ravi, Qui Dongming, Silva Laura J., Tonkovich Anna Lee

Принадлежит:

The invention described herein concerns microchannel apparatus that contains, within the same device, at least one manifold and multiple connecting microchannels that connect with the manifold. For superior heat or mass flux in the device, the volume of the connecting microchannels should exceed the volume of manifold or manifolds. Methods of conducting unit operations in microchannel devices having simultaneous disrupted and non-disrupted flow through microchannels is also described. 1. A method of conducting a unit operation in an integrated microchannel apparatus , comprising:passing a fluid in an apparatus;wherein the apparatus comprises a manifold connected to plural connecting microchannels;wherein the manifold's volume is less than the volume of the plural connecting microchannels;wherein the manifold's length is at least 15 cm or wherein there are at least 100 connecting channels connected to the manifold;controlling conditions such that the fluid is in disrupted flow through at least a portion of the connecting microchannels; andconducting a unit operation on the fluid in the connecting microchannels.2. The method of wherein the device comprises at least two manifolds claim 1 , a first manifold and a second manifold claim 1 , wherein the first manifold is connected to a first set of plural connecting microchannels and the second manifold is connected to a second set of plural connecting microchannels.3. The method of wherein a first fluid flows through the first manifold and flows in disrupted flow substantially through the first set of connecting microchannels and wherein a second fluid flows through the second manifold and flows in non-disrupted flow substantially through the second set of connecting microchannels.4. The method of wherein the manifold is a header and wherein the header has an inlet claim 1 , and wherein fluid passes through the header inlet at a Reynold's number greater than 2200.5. The method of wherein the integrated microchannel ...

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Номер записи: 21

11-02-2016 дата публикации

Techniques for Photocatalytic Hydrogen Generation

Номер: US20160040303A1

Автор: Supratik Guha, Talia S. Gershon, Teodor K. Todorov, Theodore G. Van Kessel

Принадлежит: International Business Machines Corp

Techniques for photocatalytic hydrogen generation are provided. In one aspect, a hydrogen producing cell is provided. The hydrogen producing cell includes an anode electrode; a photocatalytic material adjacent to the anode electrode; a solid electrolyte adjacent to a side of the photocatalytic material opposite the anode electrode; and a cathode electrode adjacent to a side of the solid electrolyte opposite the photocatalytic material. A solar hydrogen producing system including at least one solar concentrating assembly having the hydrogen producing cell, and a method for producing hydrogen using the hydrogen producing cell are also provided.

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Номер записи: 22

24-02-2022 дата публикации

PROCESS-INTENSIFIED FLOW REACTOR

Номер: US20220055009A1

Автор: Jean Patrick, Lavric Elena Daniela

Принадлежит:

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion. 1. A module for a flow reactor , comprising:a module body defining a fluid passage therein, the fluid passage having an interior surface and comprising a portion, the portion including (i) an input end and an outlet end at which process fluid is configured to flow into the portion and out of the portion, respectively, (ii) a plurality of successive chambers each with a nozzle-like entrance and a narrowing exit, and (iii) a cross section delimited by the interior surface of the fluid passage along the portion,wherein the cross section has a cross-sectional shape that varies continually along the portion, wherein the interior surface includes no pairs of opposing flat parallel sides at least along portions other than one or more of the entrance and the exit to the successive chambers, and wherein a plurality of obstacles are positioned along the portion between the input end and the output end.2. The module of claim 1 , wherein one chamber of said successive chambers is nested with a next-succeeding chamber of said successive chambers such that the narrowing exit of the one chamber forms the nozzle-like entrance of the next adjacent succeeding chamber.3. The module of claim 1 , wherein at least one of the plurality of obstacles is located within a first chamber and intersects a straight line having a first endpoint ...

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Номер записи: 23

03-03-2022 дата публикации

ADDRESSABLE MICRO-REACTION CHAMBER ARRAY

Номер: US20220062850A1

Автор: Jones Benjamin, Peumans Peter, Taher Ahmed, VERGAUWE Nicolas

Принадлежит:

The present invention provides a micro-reactor () adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor () comprising a fluid inlet () and a fluid outlet (); a plurality of micro-reaction chambers () arranged in rows () and columns (), each micro-reaction chamber comprising a chamber inlet () and a chamber outlet (); a plurality of supply channels () for supplying fluid to from said fluid inlet () to said micro-reaction chambers () and further arranged for draining said micro-reaction chambers () to said fluid outlet (), said supply channels () extending in a first direction (D) along the columns () of micro-reaction chambers () and arranged such that there is one supply channel () between adjacent columns (). The micro-reaction chambers () in the columns () are arranged such that the chamber inlets () of a column are in fluid contact with the same supply channel () and the chamber outlets () are in fluid contact with the supply channel () adjacent to the supply channel () arranged in fluidic contact with the chamber inlets (). Further, the plurality of supply channels () comprises a first end supply channel () arranged for supplying fluid to a first end column () of the micro-reaction chambers () and a second end supply channel () arranged for draining fluid from the second, opposite, end column () of said micro-reaction chambers (); and wherein the micro-reactor () further comprises at least one reagent inlet () in fluid contact with the first end supply channel and a reagent outlet () in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet () fill the plurality of micro-reaction chambers () in a second direction (D) along the rows () of micro-reaction chambers () to the reagent outlet ().

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Номер записи: 24

26-02-2015 дата публикации

Automatic system for synthesizing 123i-mibg and automatic device for synthesizing and dispensing 123i-mibg comprising the same

Номер: US20150056105A1

Автор: Te-Sheng Liang, Tsai-Yueh Luo, Wuu-Jyh Lin, Ying-Hsia Shih

Принадлежит: Institute of Nuclear Energy Research

The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine ( 123 I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123 I-MIBG. The present invention also relates to an automatic device for dispensing 123 I-MIBG, which comprises the automatic system for synthesizing 123 I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.

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Номер записи: 25

02-03-2017 дата публикации

Droplet producing device, droplet producing method, liposome producing method, fixture, and droplet producing kit

Номер: US20170056885A1

Автор: Hitoyoshi YAMASHITA, Masahiro Takinoue, Masamune MORITA

Принадлежит: Tokyo Institute of Technology NUC, Toppan Printing Co Ltd

A droplet producing device includes an outer tube; and an inner tube that is arranged inside the outer tube and feeds a droplet raw material, in which an inner tube discharge port opens to an inner tube tip portion formed on a downstream in a fluid feed direction, an outer tube discharge port opens to an outer tube tip portion formed on the downstream in the fluid feed direction, and in which a gap is formed between the outer tube and the inner tube.

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Номер записи: 26

27-02-2020 дата публикации

METHOD FOR MANUFACTURING POLYMER

Номер: US20200062870A1

Автор: TERANISHI Tadashi

Принадлежит: Daicel Corporation

Object: To provide a method for manufacturing a polymer, which is a method for forming a polymer having a homogeneous copolymer composition and a narrow molecular weight distribution. 1. A method for manufacturing a polymer using a microreactor comprising a flow path capable of mixing a plurality of liquids to perform radical polymerization of a monomer component containing two or more types of monomers in the presence of a polymerization initiator;wherein the microreactor comprises a first inlet port configure to feed the monomer component and an additional inlet port located downstream of the first inlet port; andthe method comprises feeding the monomer component through the first inlet port and the additional inlet port.2. The method for manufacturing a polymer according to claim 1 , wherein the monomer component to be fed through the first inlet port and the additional inlet port contains two or more types of (meth)acrylic-based monomers.3. The method for manufacturing a polymer according to claim 1 , wherein the monomers contained in the monomer component to be fed through the first inlet port and the additional inlet port are the same claim 1 , and a difference between the contents of each monomer is within ±5%.4. The method for manufacturing a polymer according to claim 2 , wherein the monomers contained in the monomer component to be fed through the first inlet port and the additional inlet port are the same claim 2 , and a difference between the contents of each monomer is within ±5%.5. The method for manufacturing a polymer according to claim 1 , wherein the radical polymerization is performed in the presence of the polymerization initiator and a chain transfer agent.6. The method for manufacturing a polymer according to claim 2 , wherein the radical polymerization is performed in the presence of the polymerization initiator and a chain transfer agent.7. The method for manufacturing a polymer according to claim 3 , wherein the radical polymerization is ...

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Номер записи: 27

15-03-2018 дата публикации

PROCESS AND SYSTEM FOR PRODUCING PULP, ENERGY, AND BIODERIVATIVES FROM PLANT-BASED AND RECYCLED MATERIALS

Номер: US20180071706A1

Автор: Barla Florin, Bobe Iulian, Kostenyuk Igor, Kumar Sandeep, Majeranowski Peter

Принадлежит:

The presently disclosed subject matter relates to an industrial system for processing various plant materials to produce marketable materials. Particularly, the system integrates subcritical water extraction technology and includes a pre-processing module and a two-stage extractor (processing module) with constant control of temperature, pressure, and/or residence time. In some embodiments, the final product of the disclosed system can include feedstock constituents for biofuel production (sugars and/or oil), biochar, raw materials for various industries (such as pulp for manufacturing paper or cellulose for use in various industries). The disclosed system can be modular or non-modular, stationary or mobile, and can include prefabricated elements with programmed automatic or manual operation so that it can be easily moved and/or assembled on site. 1. A system comprising:a pre-processing portion having a mechanical processor/material handler for extraction of water soluble fermentable carbohydrates and preparation of material for further extraction; a first operating condition at a first pressure and a first temperature at a constant level that is held for a first defined period of time to break down carbohydrates of a first chain strength; and', 'a second operating condition at a second pressure and a second temperature at a constant level that is held for a defined second period of time to break down lignin and the remaining oligo-carbohydrates of a second chain strength and fatty acids, or', 'both the first operating condition and the second operating condition;, 'an extractor portion comprising a reactor or a reactor assembly to which biomass and subcritical water is supplied, the reactor assembly havingwherein the system is repeatable until the recovery rate of the fermentable carbohydrates, fatty acid, or both reaches a desired yield.2. The system according to claim 1 , wherein the mechanical processor/material handler of the pre-processing portion includes a ...

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Номер записи: 28

05-03-2020 дата публикации

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

Номер: US20200070172A1

Автор: Gerdts Cory John, Ismagilov Rustem F., Tice Joshua David, Zheng Bo

Принадлежит:

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 115.-. (canceled)16. A system comprising:a microfluidic device comprising a substrate having a plurality of traps in fluidic communication with a channel, each trap comprises an opening along a side of the channel shaped and/or sized to accommodate a partition of a sample fluid within; anda detector to detect, monitor, or analyze each partition of sample fluid retained within a corresponding trap, the detector to detect emissions from one or more detectable markers associated with a target molecule in response to the occurrence of a polymerase-chain reaction (PCR) reaction in one or more partitions of sample fluid.17. The system of claim 16 , further comprising a plurality of partitions of sample fluid positioned within the plurality of traps in response to flow of an immiscible fluid through the channel.18. The system of claim 17 , wherein each of the plurality of partitions of sample fluid is at least partially surrounded by the immiscible fluid.19. The system of claim 18 , wherein each of the plurality of partitions of sample fluid is separated from one another and retained within a respective trap via the immiscible fluid positioned over the opening of each trap.20. The system of claim 17 , wherein the immiscible fluid is an oil.21. The system of claim 16 , wherein the target molecule is a biological molecule.22. The system of claim 21 , wherein the sample fluid comprises at least one biological molecule and one or more chemical reagents for conducting a biological reaction with the at least one biological molecule resulting in the formation of a reaction product upon undergoing the PCR reaction.23. The system of claim 22 , wherein the detector measures at least one property associated with a partition of sample fluid based on detection of emissions from the one or more ...

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Номер записи: 29

18-03-2021 дата публикации

EDGE CHIP

Номер: US20210077973A1

Автор: JR. Donald Francis, Perrault, Sharpe Johnathan Charles

Принадлежит:

Systems and methods taught herein enable simultaneous forward and side detection of light originating within a microfluidic channel disposed in a substrate. At least a portion of the microfluidic channel is located in the substrate relative to a first side surface of the substrate to enable simultaneous detection paths with respect to extinction (i.e., 0°) and side detection (i.e., 90°). The location of the microfluidic channel as taught herein enables a maximal half-angle for a ray of light passing from a center of the portion of the microfluidic channel through the first side surface to be in a range from 25 to 90 degrees in some embodiments. By placing at least the portion of the microfluidic channel proximate to the side surface of the substrate, a significantly greater proportion of light emitted or scattered from a particle within the microfluidic channel can be collected and imaged on a detector as compared to conventional particle processing chips. 1. A particle processing system comprising: a substrate having a plurality of side surfaces, a top surface, and a bottom surface, the plurality of side surfaces defining a thickness of the substrate and the top surface and the bottom surface defining a width and a length of the substrate; and', 'a microfluidic channel disposed in the substrate parallel to a first side surface of the plurality of side surfaces and located in the substrate relative to the first side surface to allow a maximal half-angle for a ray of light passing from a center of the microfluidic channel through the first side surface of between 25 degrees and 90 degrees;, 'a particle processing chip includingan electromagnetic radiation source to illuminate an interrogation region in the microfluidic channel through the bottom surface or the top surface of the substrate;a first detector to receive light from the microfluidic channel emitted through the top surface or the bottom surface of the substrate that is opposed to the electromagnetic ...

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Номер записи: 30

09-04-2015 дата публикации

Device and method for pressure-driven plug transport and reaction

Номер: US20150099264A1

Автор: Helen Song, Joshua David Tice, Lewis Spencer Roach, Rustem F. Ismagilov

Принадлежит: University of Chicago

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

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Номер записи: 31

13-04-2017 дата публикации

Flow reactor synthesis of polymers

Номер: US20170101508A1

Автор: Andrew M. Zweig, Patrick John Kinlen

Принадлежит: Boeing Co

A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

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Номер записи: 32

02-06-2022 дата публикации

Microfluidic system based on active control of flow resistance in microfluidic channels and methods of use thereof

Номер: US20220168738A1

Автор: Anne-Laure PETIT, Dalibor Hodko, Nives HODKO, Ulrich Niemann

Принадлежит: Nexongen Inc

The invention relates to a microfluidic system based on active control of flow resistance and balancing pressures in microfluidic channels and an improved method for disposable microfluidic devices and cartridges for use in, but not limited to, in-vitro diagnostics. The microfluidic system and device of the invention does not utilize mechanical moving parts to control the fluid flow and has no external fluidic connection to the instrument or fluidics controller.

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Номер записи: 33

30-04-2015 дата публикации

Microfluidic Liposome Synthesis, Purification and Active Drug Loading

Номер: US20150115488A1

Автор: Donald Lad Devoe, Renee Hood

Принадлежит: UNIVERSITY OF MARYLAND AT COLLEGE PARK

Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.

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Номер записи: 34

05-05-2016 дата публикации

SYSTEM AND METHOD FOR OPERATING PARALLEL REACTORS

Номер: US20160121291A1

Автор: Moonen Roelandus Hendrikus Wilhelmus

Принадлежит: AVANTIUM TECHNOLOGIES B.V.

A system for operating parallel reactors includes a plurality of reactor assemblies, each reactor assembly including: a flow-through reactor, a reactor feed line, a reactor effluent line, a primary fluid source, and a flow splitter which is arranged downstream of the primary fluid source and upstream of the reactor assemblies. All passive flow restrictors have an substantially equal resistance to fluid flow. A feed line pressure measurement device and a pressure control arrangement controls backpressure regulators such that the measured feed line pressure becomes substantially the same as a feed line pressure setpoint in the reactor assemblies. 1. System A system for operating parallel reactors , which system comprises: a flow-through reactor, said flow-through reactor comprising a reactor inlet and a reactor outlet,', 'a reactor feed line, which reactor feed line has a first end and a second end, said second end being connected to the reactor inlet of the flow-through reactor, said reactor feed line being adapted to supply a fluid to the flow-through reactor,', 'a reactor effluent line, which reactor effluent line has a first end, which first end is connected to the reactor outlet of the flow-through reactor, said reactor effluent line being adapted to discharge reactor effluent from the reactor,, 'a plurality of reactor assemblies, each reactor assembly comprisinga primary fluid source, which primary fluid source is adapted to provide a pressurized fluid to the flow-through reactors,a flow splitter which is arranged downstream of the primary fluid source and upstream of the reactor assemblies, said flow splitter having an inlet and multiple passive flow restrictors, wherein the inlet of the flow splitter is connected to the primary fluid source and each passive flow restrictor is in fluid communication with said inlet, and wherein each passive flow restrictor has an outlet, which outlet is connected to the first end of the reactor feed line of its own dedicated ...

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Номер записи: 35

17-07-2014 дата публикации

Characterization of reaction variables

Номер: US20140199783A1

Автор: Gunnar Kylberg, Gunnar Thorsén, Mats Inganas, Per Andersson

Принадлежит: GYROS Patent AB

A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other. The method is characterized in comprising the steps of: (i) providing a microfluidic device comprising a microchannel structures that are under a common flow control, each microchannel structure comprising a reaction microactivity; (ii) performing essentially in parallel an experiment in each of two or more of the plurality of microchannel structures, the experiment in these two or more microchannel structures comprising either a) formation of an immobilized form of the complex and retaining under flow conditions said form within the reaction microactivity, or b) dissociating, preferably under flow condition, an immobilized form of the complex which has been included in the microfluidic device provided in step (i), at least one reaction variable varies or is uncharacterized for said two or more microchannel structures while the remaining reaction variables are kept essentially constant; (iii) measuring the presentation of the complex in said reaction microactivity in said two or more microchannel structures; and (iv) characterizing said one or more reaction variables based on the values for presentation obtained in step (iii).

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Номер записи: 36

07-05-2015 дата публикации

GAS REACTOR DEVICES WITH MICROPLASMA ARRAYS ENCAPSULATED IN DEFECT FREE OXIDE

Номер: US20150125357A1

Автор: CHO JIN HOON, Eden J. Gary, KIM Min Hwan, Park Sung-Jin, SUNG Seung Hoon

Принадлежит:

A gas reactor device includes a plurality of microcavities or microchannels defined at least partially within a thick metal oxide layer consisting essentially of defect free oxide. Electrodes are arranged with respect to the microcavities or microchannels to stimulate plasma generation therein upon application of suitable voltage. One or more or all of the electrodes are encapsulated within the thick metal oxide layer. A gas inlet is configured to receive feedstock gas into the plurality of microcavities or microchannels. An outlet is configured to outlet reactor product from the plurality of microcavities or microchannels. In an example preferred device, the feedstock gas is air or Oand is converted by the plasma into ozone (O). In another preferred device, the feedstock gas is an unwanted gas to be decomposed into a desired form. Gas reactor devices of the invention can, for example, decompose gases such as CO, CH, or NOR. 1. A gas reactor device , comprising:a plurality of microcavities or microchannels defined at least partially within a thick metal oxide layer consisting essentially of defect free oxide;electrodes arranged with respect to said plurality of microcavities or microchannels to stimulate plasma generation in said plurality of microcavities or microchannels upon application of suitable voltage wherein at least one of said electrodes is encapsulated within said thick metal oxide layer;a gas inlet to receive feedstock gas into said plurality of microcavities or microchannels; andan outlet to outlet reactor product from said plurality of microcavities or microchannels.2. The device of claim 1 , comprising a feed of feedstock gas into said gas inlet.3. The device of claim 2 , wherein said plurality of microcavities or microchannels comprises a plurality of microchannels.4. The device of claim 3 , wherein the feedstock gas comprises air or Oand the reactor product comprises ozone (O).5. The device of claim 4 , comprising a plurality of microcavities ...

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Номер записи: 37

05-05-2016 дата публикации

A SOL-GEL PROCESS FOR SYNTHESIS OF NANOCRYSTALLINE OXIDES

Номер: US20160122195A1

Автор: BHAGAVATULA Lakhsmi Vara Prasad, DARBHA Venkata Ravi Kumar, KULKARNI Amol Arvind

Принадлежит: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

A Continuous flow synthesis of nanocrystalline metal oxides by rapid sol-gel process is disclosed. The process disclosed uses an impinging microjet micromixer device to obtain the nano crystalline metal oxides. A method of fabricating and assembling the impinging microjet micromixer is also disclosed herewith. 112634576. An impinging jet micromixer comprising inlets for reactant () and () being connected to metallic blocks having microscopic bore () , being connected to support plates () using support tension springs () and screw for adjusting angle of the impinging sections () , wherein mixing zone () is formed by the impinging jets coming out of said bores () wherein the angle between the impinging jets is in the range of 70-120 degrees and the aspect ratio is in the range of 0.6-1.2.2. A sol-gel process for continuous flow synthesis of nanocrystalline metal oxides using the impinging jet micromixer as claimed in claim 1 , comprising the steps of:{'b': 1', '2, 'i. pumping of water and metal alkoxide solution in a solvent continuously through inlets () and () followed by mixing, in a mixing zoneii. synthesizing wet gel samples at flow rates in the range of 10 to 20 ml Jmin for the jet diameter in the range of 100-1000 micron and at angles between jets in the range of 70-140 degree to obtain a gel;iii. ageing the gel as obtained in step (ii), vacuum drying at temperature in the range of 70 to 90° C. for a period in the range of 8 to 12 hours, followed by calcination at a temperature in the range of 350-600° C.; andiv. drying the gel as obtained in step (iii) at a temperature in the range of 80-90° C. to yield nanocrystalline Metal Oxide having BET surface area in the range of 220-520 m2 /g and average crystallite size is in the range of 4.5-6.0 pm.3. The process according to claim 2 , wherein the solvent used is methanol and toluene such that the toluene to methanol volume ratio becomes 1.60 upon the addition of equal amounts of both the reactants.4. The process ...

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Номер записи: 38

25-04-2019 дата публикации

MICROREACTOR, CHEMICAL PRODUCT MANUFACTURING SYSTEM AND MICROREACTOR MANUFACTURING METHOD

Номер: US20190118156A1

Автор: ASANO Yukako, ODA Masashi

Принадлежит:

In mixing of raw materials having different flow rate ratios (volume ratios) (different flow rates), in order to achieve a good mixing effect, the present invention includes: for raw materials having different flow rates, a high-flow-rate side flow path () through which a raw material on a high-flow-rate side flows; a low-flow-rate side flow path () through which a raw material on a low-flow-rate side flows; branch flow paths () which are branched from the high-flow-rate side flow path; and a residence flow path () which is a flow path after the branch flow paths () and the low-flow-rate side flow path () merge. The branch flow path () and the branch flow path () merge in a way of sandwiching the low-flow-rate side flow path (). 1. A microreactor , comprising:a plurality of flow paths for a plurality of raw materials with different flow rates to flow therethrough respectively,wherein the flow paths are branched and merge such that a flow path for a high-flow-rate raw material is branched into a plurality of paths and then merges to a flow path for a low-flow-rate raw material.2. The microreactor according to claim 1 , whereinfor internal volumes of flow paths when each of the raw materials finally merge, an internal volume of the flow path for the high-flow-rate raw material is larger than an internal volume of the flow path for the low-flow-rate raw material.3. The microreactor according to claim 1 , whereinthe high-flow-rate raw material, which is branched into a plurality of parts, merges simultaneously with the low-flow-rate raw material.4. The microreactor according to claim 3 , whereinthe high-flow-rate raw material merges from both sides of the low-flow-rate raw material when the high-flow-rate raw material merges with the low-flow-rate raw material.5. The microreactor according to claim 1 , whereina rear part of a merging point of the flow path for the high-flow-rate raw material and the flow path for the low-flow-rate raw material includes at least one ...

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Номер записи: 39

27-05-2021 дата публикации

DIFFERENTIAL HYDROGENATION REACTION APPARATUS

Номер: US20210154638A1

Автор: GAO Qun, XU Penghui, ZHANG Qikai

Принадлежит:

The present disclosure provides a differential hydrogenation reaction apparatus. The apparatus comprises a mixing vessel, a plurality of microreactors and a raw material conveying device, and the mixing vessel is provided with reaction product inlets; each microreactor is used as a hydrogenation reaction place and is provided with a liquid phase reaction raw material inlet and a reaction product outlet, each reaction product outlet is connected with the corresponding reaction product inlet, the plurality of microreactors are divided into one group or a plurality of groups which are arranged in parallel, and each group comprises at least one microreactor arranged in parallel; and the raw material conveying device is arranged on a feeding pipeline of the liquid phase reaction raw material inlet. The problems of high pressure unsafety and non-equilibrium in the hydrogenation reaction process can be effectively solved by adopting the reaction apparatus. 1. A differential hydrogenation reaction apparatus , comprising:a mixing vessel with reaction product inlets;{'sup': 3', '3, 'a plurality of microreactors used as hydrogenation reaction places of a liquid phase reaction raw material, wherein each of the microreactor is provided with a liquid phase reaction raw material inlet and a reaction product outlet; the reaction product outlet is connected with the corresponding reaction product inlet; the plurality of microreactors are divided into one group or a plurality of groups which are arranged in parallel, each group comprises at least one microreactor arranged in parallel; each of the microreactor in each group of the microreactors is a pressurized microreactor with a volume smaller than or equal to 0.025 mand an inside diameter smaller than 0.1 m, or an ambient-pressure microreactor with a volume smaller than or equal to 0.1 mand an inside diameter smaller than 0.1 m; and'}a raw material conveying device, arranged on a feeding pipeline of the liquid phase reaction raw ...

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Номер записи: 40

27-05-2021 дата публикации

Reactor for the preparation of a formulation

Номер: US20210154639A1

Автор: Englert Christoph, Lehmann Marc

Принадлежит:

The invention discloses a reactor for preparing a formulation. The reactor comprises at least two apertures, a base and at least one sidewall extending flush therefrom, wherein the base and the sidewall together define a mixing chamber with a height hand at least one axis of symmetry arranged substantially perpendicular to the base and at least one distance r from the sidewall. A first aperture is arranged within the base or adjacent to the base in the sidewall of the mixing chamber at a height hranging from 0.6 to 0.0 hin order to introduce free-flowing materials and/or mixtures to the mixing chamber. The first aperture is configured with a non-return valve disposed therein or adjacent thereto, the non-return valve permitting the introduction of free-flowing materials to the mixing chamber through the aperture, but preventing outflow of free-flowing materials from the mixing chamber through the aperture. The first aperture is formed with an aperture area extending in a range between a minimum and a maximum, the minimum area being 0.05 mmand the maximum area being determined by a value resulting from Volume[cm]/Area[cm]≈5500. 1. Reactor for preparing a formulation , wherein the reactor comprises at least two apertures , a base and at least one sidewall extending flush therefrom , wherein the base and the sidewall together define a mixing chamber with a height hand at least one axis of symmetry arranged substantially perpendicular to the base and at least one distance r from the sidewall ,{'sub': A', 'M, 'wherein a first aperture is arranged within the base or adjacent to the base in the sidewall of the mixing chamber at a height hranging from 0.6 to 0.0 hin order to introduce free-flowing materials and/or mixtures to the mixing chamber, and wherein the first aperture is configured with a non-return valve disposed therein or adjacent thereto, the non-return valve permitting the introduction of free-flowing materials to the mixing chamber through the aperture, but ...

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Номер записи: 41

12-05-2016 дата публикации

Coalescence of droplets

Номер: US20160129444A1

Автор: David A. Weitz, Donald Aubrecht, Ilke Akartuna, Thomas E. Kodger

Принадлежит: Harvard College

The present invention generally relates to microfiuidics, and, in particular, to systems and methods for coalescing or fusing droplets. In certain aspects, two or more droplets within a microfluidic channel are brought together and caused to coalesce without using electric fields or charges. For example, in certain embodiments, droplets stabilized with a surfactant may be disrupted, e.g., by exposing the droplets to a solvent able to alter the surfactant, which may partially destabilize the droplets and allow them to coalesce. In some instances, the droplets may also be physically disrupted to facilitate coalesce. In addition, in some cases, the positions of one or more droplets may be controlled within a channel using a groove in a wall of the channel. For example, a droplet may at least partially enter the groove such that the position of the droplet is at least partially controlled by the groove.

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Номер записи: 42

02-05-2019 дата публикации

COUNTERCURRENT HEAT EXCHANGER/REACTOR

Номер: US20190128612A1

Автор: Chordia Lalit, Davis John C.

Принадлежит: Thar Energy LLC

Counter-flow heat exchanged is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below. 130-. (canceled)31. A device including channels arranged for countercurrent flow comprising:a bundle of channels comprising a first plurality of channels and a second plurality of channels configured to flow fluids counter-currently in opposite directions whereby opposing streams of fluid are arranged in a checkerboard pattern, such that for any given channel there exist alongside, in four directions, laterally on both sides, above and below, channels containing the opposite fluid;wherein the second plurality of channels confines one of the opposing streams through a plenum area at either end of the bundle, and extends into a cavity through which fluid enters or exits the device by second flowstream ports in a wall of the cavity; andwherein the second plurality of channels that penetrates the plenum area may be altered in size or shape, or both size and shape, so as to ensure free space completely around the second plurality of channels, such that fluid is free to flow between the second plurality of channels to or from first flowstream ports.32. The device of wherein the areal density of the bundle of channels is greater than 400 m/m.33. The device of wherein a heat transfer coefficient is enhanced by means of structural changes in walls of the individual channels claim 31 , leading to increased turbulence in the flowing stream.34. The device of wherein a cross-sectional shape of individual channels in the first plurality of channels is a hollow polygon of no more than four sides claim 31 , while a cross-sectional shape of the second plurality of channels takes the form of any shape and size claim 31 , including the voids created between the walls of the first ...

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Номер записи: 43

17-05-2018 дата публикации

REACTOR INCORPORATING A HEAT EXCHANGER

Номер: US20180134551A1

Автор: Contini Vincent, George, Goshe Matthew E., II Paul E.

Принадлежит:

A reactor containing a heat exchanger is disclosed, which can be operated with co-current or counter-current flow. Also disclosed is a system that includes a reactor having a reformer and a vaporizer, a fuel supply, and a water supply. The reactor includes a source of combustion gas, a reformer operative to receive reformate, and a vaporizer operative to receive water. The reformer and vaporizer each include a stack assembly formed by a combination of separator shims and channel shims. The separator shims and channel shims are stacked in a regular pattern to form two sets of channels within the stack assembly. One set of channels will have vertical passageways at either end and a horizontal flowpath between them, while the other set of channels has only a horizontal flowpath. 1. A heat exchanger , comprising:a first channel having a flowpath, a first wall, a second wall opposite the first wall, an inlet manifold at a first end, and an outlet manifold at a second opposite end, the inlet manifold and the outlet manifold running orthogonal to the flowpath;a second channel having a flowpath parallel to the flowpath of the first channel, the first channel and the second channel being separated by the first wall; anda fin extending from the second channel into the first channel, the fin passing through the first wall and extending to the second wall;wherein the heat exchanger is formed from a channel shim and a separator shim, wherein the channel shim defines the first channel, and wherein the separator shim includes the fin; andwherein the channel shim and the separator shim cooperate to form the first wall.2. The heat exchanger of claim 1 , wherein the first channel has a plurality of micro-channels and the second channel has a plurality of micro-channels 0.3. The heat exchanger of claim 2 , wherein the ratio of a first micro-channel width to a first micro-channel height is from 2:1 to 20:1.4. The heat exchanger of claim 1 , wherein the ratio of a channel shim height to ...

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Номер записи: 44

17-06-2021 дата публикации

MICROCHEMICAL SYSTEM APPARATUS AND RELATED METHODS OF FABRICATION

Номер: US20210178387A1

Автор: Kwon Patrick, Yeom Junghoon

Принадлежит:

The disclosure relates to microchemical (or microfluidic) apparatus as well as related methods for making the same. The methods generally include partial sintering of sintering powder (e.g., binderless or otherwise free-flowing sintering powder) that encloses a fugitive phase material having a shape corresponding to a desired cavity structure in the formed apparatus. Partial sintering removes the fugitive phase and produces a porous compact, which can then be machined if desired and then further fully sintered to form the final apparatus. The process can produce apparatus with small, controllable cavities shaped as desired for various microchemical or microfluidic unit operations, with a generally smooth interior cavity finish, and with materials (e.g., ceramics) able to withstand harsh environments for such unit operations. 120-. (canceled)21. A microchemical apparatus comprising:a fully sintered metal oxide body comprising an interior cavity within the body; the interior cavity has a minimum dimension in a range from 1 μm to 1000 μm; and', 'the interior cavity has a surface roughness of 20 μm or less., 'wherein22. The microchemical apparatus of claim 21 , wherein the fully sintered metal oxide body has a density of at least 80% relative to the theoretical density of the metal oxide.23. The microchemical apparatus of claim 21 , wherein the interior cavity is fully enclosed by the fully sintered metal oxide body.24. The microchemical apparatus of claim 21 , wherein the interior cavity is partially enclosed by the fully sintered metal oxide body. Priority is claimed to U.S. Provisional Application No. 62/378,932 filed Aug. 24, 2016, which is incorporated herein by reference in its entirety.None.The disclosure relates to relates to microchemical (or microfluidic) apparatus as well as related methods for making the same. The methods generally include partial sintering of sintering powder, removal of a fugitive phase material within the powder to create internal ...

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Номер записи: 45

11-06-2015 дата публикации

Dose Synthesis Card for Use with Automated Biomarker Production System

Номер: US20150157743A1

Автор: Anzellotti Atilio, Brown-Proctor Clive, Hillesheim Daniel, Khachaturian Mark Haig, Land Andrew, McFarland Aaron

Принадлежит:

Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall. 1. A disposable microfluidic radiopharmaceutical synthesis card system comprising:at least one reaction vessel adapted to receive a radioisotope and at least one reagent, said reaction vessel being configured to receive energy from an energy source , whereby when said radioisotope and said at least one reagent are mixed in said reaction vessel and energy is provided to said reaction vessel from said energy source, a radiopharmaceutical solution is synthesized;at least one purification component to purify said radiopharmaceutical solution;a filter adapted to sterilize said radiopharmaceutical solution;a sterile vessel adapted to receive sterile radiopharmaceutical solution following the passage of said radiopharmaceutical solution through said purification column and said filter, said sterile vessel configured to hold multiple unit doses of radiopharmaceutical; anda port in said vessel used to ...

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Номер записи: 46

01-06-2017 дата публикации

SCALE-UP OF MICROFLUIDIC DEVICES

Номер: US20170151536A1

Автор: Abate Adam R., Romanowsky Mark, Weitz David A.

Принадлежит:

Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices. 178-. (canceled)79. A system for forming droplets in microfluidic channels in parallel , comprising a distribution channel connecting a source of a dispersing fluid to a plurality of dispersing fluid outlets , wherein a given dispersing fluid outlet of the plurality is directly fluidly connected to a given microfluidic interconnected region of a plurality of microfluidic interconnected regions arranged in parallel , wherein a given microfluidic interconnected region of the plurality of microfluidic interconnected regions joins a subject fluid channel for carrying a subject fluid and a dispersing fluid channel for carrying the dispersing fluid , wherein at least a portion of an outer wall of the given microfluidic interconnected region and a portion of an outer wall of the subject fluid channel are portions of a single integral unit.80. The system of claim 79 , wherein the outer wall of the interconnected region is exterior of the outer wall of the subject fluid channel.81. The system of claim 79 , further comprising a dimensionally-restricted section formed by extensions extending from the outer wall of the given microfluidic interconnected region into the given microfluidic interconnected region claim 79 , wherein the dimensionally-restricted section is positioned adjacent to a subject fluid channel outlet.82. The system of claim 81 , wherein the dimensionally-restricted section has a shape which causes the dispersing ...

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Номер записи: 47

07-06-2018 дата публикации

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

Номер: US20180154362A1

Автор: Ismagilov Rustem F., Roach Lewis Spencer, Song Baca Helen, Tice Joshua David

Принадлежит:

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 120.-. (canceled)21. A method of conducting an autocatalytic reaction comprising forming a plurality of plugs and conducting the autocatalytic reaction in at least one plug , wherein:each plug comprises an aqueous fluid surrounded by a hydrophobic fluid;the aqueous fluid of at least one plug comprises a biological reagent;the hydrophobic fluid of each plug comprises a fluorosurfactant; andthe fluorosurfactant comprises oligoethylene glycol (OEG).22. The method of claim 21 , wherein the plugs are formed in a microchannel.23. The method of claim 21 , further comprising sorting the plugs.24. The method of claim 21 , wherein the autocatalytic reaction is a polymerase-chain reaction (PCR).25. The method of claim 21 , wherein at least one plug comprises a single biological reagent.26. The method of claim 25 , wherein the single biological reagent is DNA or RNA.27. The method of claim 21 , wherein the fluorosurfactant comprises an oligoethylene glycol terminal.29. The method of claim 27 , where the oligoethylene glycol is linked to a terminal end of the fluorosurfactant.30. The method of claim 21 , wherein the fluorosurfactant is linked to the oligoethylene glycol (OEG).31. A method of preparing a composition comprising a plurality of plugs claim 21 , the method comprising:flowing an aqueous fluid in a first microchannel toward a junction, the aqueous fluid comprising a biological reagent;flowing a hydrophobic fluid that is immiscible with the aqueous fluid in a second microchannel toward the junction, the hydrophobic fluid comprising a fluorosurfactant comprising oligoethylene glycol (OEG); andcontacting the aqueous fluid with the hydrophobic fluid at the junction and forming a plurality of plugs at the junction, wherein each plug comprises a subvolume of the aqueous fluid surrounded ...

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Номер записи: 48

15-06-2017 дата публикации

MICROFLUIDIC DROPLET PACKING

Номер: US20170165669A1

Автор: Esmail Adnan, Hung Tony, Kiani Sepehr, Powers Scott

Принадлежит:

Systems and methods for confining droplets within a microfluidic channel as well as systems and methods for packing droplets are provided. More specifically, a system and method are provided for controlling the introduction and removal of oil into a microfluidic channel in order to control where drops are allowed to flow within that channel. 1. A method of controlling aqueous droplets in an emulsion comprising a non-aqueous continuous fluid , the method comprising ,providing a microfluidic channel defined by two substantially parallel or non-parallel walls, wherein each wall comprises one or more opposing ports, wherein said microfluidic channel contains an emulsion comprising aqueous droplets in the continuous non-aqueous fluid;causing the emulsion to flow from an upstream position in the microfluidic channel to a downstream position in the channel while introducing non-emulsion continuous non-aqueous fluid into the microfluidic channel from the ports, such that the aqueous droplets in the emulsion are more densely packed at the downstream position compared to the upstream position.2. The method of claim 1 , wherein non-emulsion continuous non-aqueous fluid from one or more port on a first wall of the microfluidic channel flows at a stronger pressure than non-emulsion continuous non-aqueous fluid from port(s) of the opposing wall such that a majority of droplets at the downstream position are closer to the opposing wall than to the first wall of the microfluidic channel.3. The method of claim 1 , wherein each wall of the microfluidic channel comprises at least an upstream port and a downstream port claim 1 , wherein the upstream port in each wall introduces non-emulsion continuous non-aqueous fluid into the microfluidic channel at a first pressure and wherein the downstream port in each wall introduces non-emulsion continuous non-aqueous fluid into the microfluidic channel at a second pressure.4. The method of claim 3 , wherein the first pressure and the second ...

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Номер записи: 49

08-07-2021 дата публикации

A PULSED FLOW REACTOR AND USE THEREOF

Номер: US20210205776A1

Автор: Debrouwer Wouter, Metten Bert D F, Toye Koen, Van Aken Koen Jeanne Alfons

Принадлежит:

A planar flow reactor includes a straight planar process channel, a flow generator, and a plurality of static mixing elements disposed within the process channel. The flow generator is configured to generate a pulsatile flow within the process channel, and the static mixing elements are configured to locally split and recombine the flow. The straight planar process channel enables the generation of a flow pattern that is largely independent of the width of the process channel, meaning that the throughput may be increased by increasing the width without significantly affecting the residence time distribution or the flow behavior. Furthermore, by creating a pulsatile flow within the process channel, turbulence and/or chaotic fluid flows may be generated even at low net flow rates, i.e. low net Reynolds numbers. 1. A flow reactor comprising:a straight planar process channel having a longitudinal direction and being delimited by a bottom wall, a top wall, two side walls, a first end wall, and a second end wall opposite to said first end wall along said longitudinal direction, the process channel comprising at least one inlet at said first end wall configured to introduce at least one feed stream into said process channel and at least one outlet at said second end wall configured to discharge at least one product stream from said process channel;a flow generator configured to generate a pulsatile flow within said process channel, the pulsatile flow comprising a unidirectional net flow component through said process channel along said longitudinal direction and an oscillatory flow component superposed on said net flow component; anda plurality of static mixing elements disposed within said process channel and configured to locally split and recombine the pulsatile flow.2. The flow reactor according to claim 1 , wherein said flow generator is configured to generate said pulsatile flow with a normalized oscillatory Reynolds number that is at least 5v claim 1 , where v is a ...

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Номер записи: 50

30-06-2016 дата публикации

MICROCHEMICAL CHIP AND REACTION DEVICE

Номер: US20160184789A1

Автор: Takagi Kazuhisa, TAKANO Tsutomu

Принадлежит: ASAHI FR R&D CO., LTD.

A simple and compact microchemical chip has a fine flow path formed therein through which a specimen is made to flow; is break resistance; makes it possible to flow the fluid sample to the flow path; makes it possible to analyze a useful substance and cause it to react; and can be produced with a high yield. A microchemical chip includes: a rubber sheet having a penetrated flow path which chemically reacts a pressurized fluid sample selected from a specimen and a reagent by flowing thereinto; substrate sheets which sandwich the rubber sheet and bond to both faces thereof by direct bond or by chemical bond through a silane-coupling agent and are selected from metal, ceramics, glass, and resin; and a hole for injecting the fluid sample into the flow path and a hole for draining the fluid sample flowed therefrom which are opened into the substrate sheet. 1. A microchemical chip comprising:a rubber sheet having a penetrated flow path which chemically reacts a pressurized fluid sample selected from a specimen and a reagent by flowing thereinto;substrate sheets which sandwich the rubber sheet and bond to both faces thereof by direct bond or by chemical bond through a silane-coupling agent and are selected from the group consisting of metal, ceramics, glass, and resin; anda hole for injecting the fluid sample into the flow path and a hole for draining the fluid sample flowed therefrom which are opened into the substrate sheet.2. The microchemical chip according to claim 1 , wherein the rubber sheet and the substrate sheets are bonded by the chemical bond which is formed under conditions of reduced pressure and/or pressurization.3. The microchemical chip according to claim 1 , wherein the rubber sheet and the substrate sheets are bonded by the chemical bond which is formed under conditions of pressurization and/or heating after reduced pressure condition.4. The microchemical chip according to claim 1 , wherein the rubber sheet and/or the substrate sheet are given an active ...

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Номер записи: 51

13-06-2019 дата публикации

SYSTEMS AND METHODS FOR PRODUCING A CHEMICAL PRODUCT

Номер: US20190176122A1

Автор: Koswara Andy, Nagy Zoltan Kalman, Parks Conor Douglas

Принадлежит:

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product. 1. A system for producing a chemical product , the system comprising:a chemical product production unit comprising a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow; anda droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.2. The system according to claim 1 , further comprising a controller.3. The system according to claim 2 , wherein the system comprises one or more sensors.4. The system according to claim 3 , wherein the controller is configured to receive data from the sensors that allow the controller to monitor a process occurring in one or more of the microfluidic modules.5. The system according to claim 4 , wherein the controller is configured to adjust one or more parameters within the one or more of the microfluidic modules based on the received data.6. The system according to claim 2 , wherein the chemical product is a pharmaceutical drug and the controller comprises a program that determines an optimal drug ...

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Номер записи: 52

29-06-2017 дата публикации

Microfluidic Liposome Synthesis, Purification and Active Drug Loading

Номер: US20170181972A1

Автор: DeVoe Donald Lad, Hood Renee

Принадлежит: University of Maryland, College Park

Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels. 1. A microfluidic device for synthesis of liposomes , comprising:a sample flow channel;a first inlet channel in fluid communication with said sample flow channel; andsecond and third inlet channels in fluid communication with said sample flow channel, said first, second and third inlet channels converging at a flow focusing region within said sample flow channel, wherein said sample flow channel has an aspect ratio (height:width) exceeding 20:1 at said flow focusing region.2. The microfluidic device of claim 1 , wherein said aspect ratio is 50:1 or greater.3. The microfluidic device of claim 1 , wherein said aspect ratio is 100:1 or greater.4. The microfluidic device of claim 1 , wherein said first claim 1 , second and third inlet channels are vertically oriented relative to each other. This application is a divisional of U.S. patent application Ser. No. 14/524,797, filed Oct. 27, 2014, which application is based on U.S. Provisional Patent Application Ser. No. 61/896,204, filed Oct. 28, 2013, which applications are incorporated herein by reference in their entireties and to which priority is claimed.This work was supported by the National Science Foundation (NSF) under CBET0966407 grant. The US government has certain rights in this invention.The present invention relates to microfluidic methods and systems for continuous flow synthesis of nanoparticles, and in particular microfluidic systems for preparing drug-loaded liposomes as well as microfluidic systems for high throughput ...

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Номер записи: 53

18-09-2014 дата публикации

Reactor incorporating a heat exchanger

Номер: US20140272643A1

Автор: II Paul E. George, Matthew E. Goshe, Vincent Contini

Принадлежит: Battelle Memorial Institute Inc

A reactor containing a heat exchanger is disclosed, which can be operated with co-current or counter-current flow. Also disclosed is a system that includes a reactor having a reformer and a vaporizer, a fuel supply, and a water supply. The reactor includes a source of combustion gas, a reformer operative to receive reformate, and a vaporizer operative to receive water. The reformer and vaporizer each include a stack assembly formed by a combination of separator shims and channel shims. The separator shims and channel shims are stacked in a regular pattern to form two sets of channels within the stack assembly. One set of channels will have vertical passageways at either end and a horizontal flowpath between them, while the other set of channels has only a horizontal flowpath.

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Номер записи: 54

04-06-2020 дата публикации

Liquid-Liquid Mass Transfer Process and Apparatus

Номер: US20200171408A1

Автор: Jagger John, Nagarajan Raj, Vudutha Chaitanya Sathaiah

Принадлежит: MERICHEM COMPANY

A fiber bundle contactor may include a vessel including a first inlet; a second inlet; a mixing zone arranged in the vessel to receive a first fluid from the first inlet and a including fluid from the second inlet, wherein the mixing zone comprises a perforated plate assembly comprising a plate, a plurality of openings in the plate, and a plurality of riser pipes that extend from the plate and arranged to allow fluid flow through additional openings in the plate; and an extraction zone including a fiber bundle arranged in the vessel to receive the first fluid and the second fluid from the mixing zone. 1. A fiber bundle contactor comprising: a first inlet;', 'a second inlet;', 'a mixing zone arranged in the vessel to receive a first fluid from the first inlet and a second fluid from the second inlet, wherein the mixing zone comprises a perforated plate assembly comprising a plate, a plurality of openings in the plate, and a plurality of riser pipes that extend from the plate and are arranged to allow fluid flow through additional openings in the plate; and', 'an extraction zone comprising a fiber bundle arranged in the vessel to receive the first fluid and the second fluid from the mixing zone., 'a vessel comprising2. The fiber bundle contactor of further comprising a distributor coupled to the second inlet wherein the distributor comprises a spiral distributor or an arm distributor.3. The fiber bundle contactor of wherein the distributor comprises a plurality of spaced apart holes and a flow path from the second inlet to the plurality of spaced apart holes.4. The fiber bundle contactor of further comprising an inductor fluidically coupled to the at least some of the spaced apart holes.5. The fiber bundle contactor of wherein the inductor comprises:a reducer body with a flow path disposed therein and fluidically coupled to the second inlet;a first reducer cone disposed on the reducer body such that the flow path disposed in the reducer body extends through the first ...

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Номер записи: 55

04-06-2020 дата публикации

DEVICE FOR MANIPULATION OF PACKETS IN MICRO-CONTAINERS, IN PARTICULAR IN MICROCHANNELS

Номер: US20200171499A1

Автор: Chabert Max, DORFMAN Kevin, VIOVY Jean-Louis

Принадлежит:

A microfluidic device for performing physical, chemical or biological treatment to at least one packet without contamination. 1. A device for performing a PCR , comprising:a microchannel comprising a coil comprising a capillary tube defining an internal space of the microchannel, wherein the capillary tube comprises a non internally coated bulk fluorinated material; a carrier fluid comprising a fluorosolvent containing a surfactant, and', 'aqueous droplets surrounded by the carrier fluid,, 'wherein the capillary tube is at least partly filled withthe coil comprising a denaturing region and an annealing region, both regions being at different temperatures, wherein the difference between the interfacial tension between a droplet and the capillary tube and the interfacial tension between the droplet and the carrier fluid is at least 26 mN/m.2. The device according to claim 1 , wherein the bulk fluorinated material is a fluoropolymer.3. The device according to claim 1 , comprising a cylinder comprising three regions corresponding to the denaturing claim 1 , annealing and elongation regions.4. The device according to claim 3 , the capillary tube being wound around the cylinder.5. The device according to claim 3 , the denaturing claim 3 , annealing and elongation regions being isolated one from another by sheets claim 3 , which are affixed between the pieces of the cylinder.6. The device according to claim 1 , the device having a cylinder shape and comprising three ventilation holes per quarter cylinder claim 1 , said holes being drilled through the entire device to provide vents for air cooling.7. The device according to claim 6 , further comprising a turbine configured to blow ambient air through the ventilation holes providing temperature control and uniformity.8. The device according to claim 1 , the device having a cylinder shape claim 1 , two holes for receiving thermocouples and one central hole for receiving a heater being drilled partially through the cylinder in ...

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Номер записи: 56

12-07-2018 дата публикации

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

Номер: US20180193837A1

Автор: Ismagilov Rustem F., Roach Lewis Spencer, Song Baca Helen, Tice Joshua David

Принадлежит:

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 120.-. (canceled)21. A microfluidic device comprising:two or more microchannels that intersect at a first junction;a first outlet channel extending from the first junction;a second junction where the first outlet channel intersects at least one other microchannel; anda second outlet channel from the first junction.22. The microfluidic device of claim 21 , wherein the microfluidic device comprises a substrate in which the two or more microchannels claim 21 , the first outlet channel claim 21 , the at least one other microchannel claim 21 , and the second outlet channel are formed.23. The microfluidic device of claim 22 , wherein the substrate comprises a material selected from the group consisting of glass claim 22 , silicon claim 22 , a silicone elastomer claim 22 , and a polymer.24. The microfluidic device of claim 23 , wherein the substrate material comprises polypropylene or polyethylene.25. The microfluidic device of claim 23 , wherein the substrate comprises polydimethylsiloxane (PDMS).26. The microfluidic device of claim 25 , wherein the microfluidic device is a PDMS-based microfluidic chip.27. The microfluidic device of claim 21 , wherein the two or more channels intersect one another at the first junction at an angle of at least 45°.28. The microfluidic device of claim 21 , wherein the first outlet channel intersects the at least one other microchannel at the second junction at an angle of at least 45°.29. The microfluidic device of claim 21 , wherein the two or more microchannels and the at least one other microchannel have an inlets that are separate from one another.30. The microfluidic device of claim 21 , wherein each of the two or more microchannels claim 21 , the first outlet channel claim 21 , the at least one other microchannel claim 21 , and the second outlet ...

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Номер записи: 57

12-07-2018 дата публикации

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

Номер: US20180193838A1

Автор: Ismagilov Rustem F., Roach Lewis Spencer, Song Baca Helen, Tice Joshua David

Принадлежит:

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 120. -. (canceled)21. A method comprising:flowing a first plug fluid stream in a first microchannel toward a junction, the first plug fluid stream comprising an enzyme;flowing a second plug fluid stream in a second microchannel toward the junction, the second plug fluid stream comprising a reactant, wherein the first and second plug fluid streams meet at a first junction such that the enzyme and the reactant co-flow with each other downstream of the first junction toward a second junction; andflowing a carrier fluid that is immiscible with the first and second plug fluid streams to the second junction; andforming a plurality of plugs at the second junction, each of the plurality of plugs being separated by the carrier fluid and at least one of the plurality of plugs comprising the enzyme and the reactant.22. The method of claim 21 , wherein the carrier fluid is an oil.23. The method of claim 21 , wherein the enzyme and reactant within the at least one plug allow for a reaction to occur.24. The method of claim 23 , wherein the reaction is an autocatalytic reaction.25. The method of claim 24 , wherein the autocatalytic reaction is a polymerase-chain reaction (PCR).26. The method of claim 21 , wherein the reactant comprises at least one of a synethetic molecule and a biological molecule.27. The method of claim 26 , wherein the biological molecule is DNA or RNA.28. The method of claim 26 , wherein the biological molecule is a protein.29. The method of claim 26 , wherein the biological molecule is secreted from a cell.30. The method of claim 26 , wherein the at least one plug comprises a single biological molecule.31. The method of claim 21 , wherein at least one of the first and second plug fluids comprises a reagent.32. The method of claim 21 , wherein at least one of the first ...

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Номер записи: 58

27-06-2019 дата публикации

Microparticle Forming Device

Номер: US20190193043A1

Автор: Huang Yao-Kun, HUNG CHENG-HAN, LIN CHIU-FENG, LIN YING-CHIEH, Liu Zong-Hsin, Lu Ying-Cheng, Tsai Ming-Fang

Принадлежит:

A microparticle forming device is used to form microparticles with uniform particle size and proper roundness, and includes a collection pipe, a fluid nozzle, a reactor and a filter. The collection pipe includes a fluid passage, an aqueous-phase fluid inlet, an oil-phase fluid inlet and a mixed fluid outlet, all of which are communicated with the fluid passage. The oil-phase fluid inlet is located between the aqueous-phase fluid inlet and the mixed fluid outlet. The fluid nozzle has a plurality of oil-phase fluid drop outlets aligned with the oil-phase fluid inlet of the collection pipe. The reactor has a reaction chamber communicated with the mixed fluid outlet of the collection pipe, a mixing member accommodated in the reaction chamber, and a microparticle collection port communicated with the reaction chamber. Two opposite ends of the filter are respectively communicated with the reaction chamber of the reactor. 1. A microparticle forming device comprising:a collection pipe including a fluid passage, an aqueous-phase fluid inlet, an oil-phase fluid inlet and a mixed fluid outlet; wherein the fluid passage, the aqueous-phase fluid inlet, the oil-phase fluid inlet and the mixed fluid outlet are communicated with the fluid passage, and wherein the oil-phase fluid inlet is located between the aqueous-phase fluid inlet and the mixed fluid outlet;a fluid nozzle including a plurality of oil-phase fluid drop outlets aligned with the oil-phase fluid inlet of the collection pipe; anda reactor including a reaction chamber communicated with the mixed fluid outlet of the collection pipe, a mixing member accommodated in the reaction chamber, and a microparticle collection port communicated with the reaction chamber.2. The microparticle forming device as claimed in claim 1 , wherein the collection pipe includes a propelling member disposed in the fluid passage.3. The microparticle forming device as claimed in claim 1 , wherein the fluid nozzle is connected with an oil-phase ...

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Номер записи: 59

18-06-2020 дата публикации

PROCESS AND SYSTEM FOR PRODUCING PULP, ENERGY, AND BIODERIVATIVES FROM PLANT-BASED AND RECYCLED MATERIALS

Номер: US20200188872A1

Автор: Barla Florin, Bobe Iulian, Kostenyuk Igor, Kumar Sandeep, Majeranowski Peter

Принадлежит:

The presently disclosed subject matter relates to an industrial system for processing various plant materials to produce marketable materials. Particularly, the system integrates subcritical water extraction technology and includes a pre-processing module and a two-stage extractor (processing module) with constant control of temperature, pressure, and/or residence time. In some embodiments, the final product of the disclosed system can include feedstock constituents for biofuel production (sugars and/or oil), biochar, raw materials for various industries (such as pulp for manufacturing paper or cellulose for use in various industries). The disclosed system can be modular or non-modular, stationary or mobile, and can include prefabricated elements with programmed automatic or manual operation so that it can be easily moved and/or assembled on site. 1. (canceled)2. A method of producing pulp comprising:processing a feedstock into a processing size; andusing a subcritical water treatment process, treating the feedstock with a catalyst that comprises an alkaline catalyst at a concentration of about 1.5 to 10 weight percent or less in a reactor assembly having:an operating condition at a pressure and a temperature at a constant level that is held for a defined period of time to break down carbohydrates of a first chain strength to produce a pulp product.3. The method of claim 2 , wherein the feedstock comprises one or more of seeds and agricultural crop wastes and residues such as corn stover claim 2 , wheat straw claim 2 , rice straw claim 2 , sugar cane bagasse claim 2 , and hemp.4. The method of claim 2 , wherein the feedstock comprises hemp.5. The method of claim 2 , wherein the method provides for continuous flow of material through the reactor such that the process provides for continuous manufacture of paper pulp product claim 2 , cellulose claim 2 , or combinations thereof.6. The method of claim 2 , wherein the method is modular and scalable claim 2 , stationary ...

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Номер записи: 60

06-08-2015 дата публикации

CATALYTIC PLATE REACTORS

Номер: US20150217259A1

Автор: Baldea Michael, Pattison Richard Chase

Принадлежит:

A method of controlling the temperature of autothermal microchannel reactors is disclosed. A hierarchical control structure employs a distributed temperature controller including a phase change material and a supervisory control system including the control of one or more inputs into the reactor. The phase change material acts as a fast, distributed controller, and the supervisory controller acts over a longer time horizon to mitigate persistent disturbances. A stochastic optimization method for selecting the phase change layer thickness is employed. 1. An apparatus for processing a first substance , the apparatus comprising:a first enclosed channel configured to transport the first substance;a second enclosed channel configured to transport a second substance; anda phase change layer disposed between, and thermally coupled to, the first and the second enclosed channels.2. The apparatus of wherein the first enclosed channel further comprises a first catalyst configured to promote the chemical transformation of the first substance; andthe second enclosed channel further comprises a second catalyst configured to promote the chemical transformation of the second substance.3. The apparatus of wherein the chemical transformation of the first substance is endothermic; andthe chemical transformation of the second substance is exothermic.4. The apparatus of wherein the phase change layer is configured to change from a solid to a liquid when the exothermic transformation generates more energy than the endothermic transformation requires.5. The apparatus of wherein energy from the exothermic transformation in the first enclosed channel is conducted to the second enclosed channel and is sufficient to enable the endothermic transformation.6. The apparatus of wherein the phase change layer is configured to have a melting temperature above a normal/nominal operating temperature of the apparatus.7. The apparatus of wherein the phase change layer comprises copper.8. The apparatus ...

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Номер записи: 61

26-07-2018 дата публикации

MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE

Номер: US20180208412A1

Автор: Bunner Bernard, Deshpande Manish, Gilbert John R.

Принадлежит:

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip. 1. A sheath flow structure for suspending a particle in a sheath fluid , comprising:a primary sheath flow channel for conveying a sheath fluid;a sample inlet for injecting a particle into the sheath fluid conveyed through the primary sheath flow channel;a primary focusing region for focusing the sheath fluid around the particle in at least a first direction; anda secondary focusing region provided downstream of the primary focusing region for focusing the sheath fluid around the particle in at least a second direction different from the first direction.242-. (canceled) The present invention is a continuation of U.S. patent application Ser. No. 15/269,556, filed Sep. 19, 2016, which is a continuation of U.S. patent application Ser. No. 13/968,962, filed Aug. 16, 2013, now U.S. Pat. No. 9,446,912, which is a continuation of U.S. patent application Ser. No. 13/179,084, filed Jul. 8, 2011 and now U.S. Pat. No. 8,529,161, which is a continuation of U.S. patent application Ser. No. 12/610,753, now U.S. Pat. No. 7,997,831, entitled “Multilayer Hydrodynamic Sheath Flow Structure” and filed Nov. 2, 2009, which is a continuation application of U.S. patent application Ser. No. 11/998,557, now U.S. Pat. No. 7,611,309, entitled “Multilayer Hydrodynamic ...

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Номер записи: 62

28-07-2016 дата публикации

METHOD AND DEVICE FOR PRODUCING A CATALYST

Номер: US20160218370A1

Автор: FUJISAWA Tsugio, KITAO Noriyuki, MATSUOKA Akira, NOISHIKI Koji, OOZONO Tomohiro

Принадлежит:

Disclosed is a method for producing a catalyst, wherein the method comprises: a supplying step of supplying a dispersion containing a palladium-containing fine particle from a supplying part into a reaction container; a preparing step of preparing a copper-palladium-containing complex in which at least part of a surface of the palladium-containing fine particle is covered with copper, by passing the dispersion through a reacting part and bringing the palladium-containing fine particle in the dispersion into contact with a copper-containing member in the reacting part; and a substituting step of substituting the copper in the copper-palladium-containing complex emitted from an emitting part with platinum by bringing the complex into contact with a platinum-containing solution. 1. A method for producing a catalyst comprising a fine catalyst particle which comprises a palladium-containing fine particle and a platinum-containing outermost layer covering at least part of the palladium-containing fine particle ,wherein a reaction container comprising (1) a supplying part, (2) a reacting part inside which one or more copper-containing members are provided, and (3) an emitting part is used;wherein at least part of a surface of the copper-containing member contains at least one copper-containing material selected from the group consisting of copper, a copper alloy and a copper compound; and a supplying step of supplying a dispersion containing the palladium-containing fine particle from the supplying part into the reaction container;', 'a preparing step of preparing a copper-palladium-containing complex in which at least part of a surface of the palladium-containing fine particle is covered with copper, by passing the dispersion through the reacting part and bringing the palladium-containing fine particle in the dispersion into contact with the copper-containing member in the reacting part; and', 'a substituting step of substituting the copper in the copper-palladium- ...

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Номер записи: 63

09-08-2018 дата публикации

FLOW ELEMENT HAVING AN INTEGRATED CAPILLARY LINE FOR TRANSFERRING FLUIDS

Номер: US20180221844A1

Автор: BRASCHKAT Joerg, Brenner Armin, GUELLICH Frank, KEIM Sebastian, KOECHEL Oliver

Принадлежит: hte GmbH the high throughput experimentation company

The invention relates to a flow element for transferring fluids comprising a capillary cartridge () having an integrated capillary line (). The capillary cartridge according to the invention () has a ring-shaped channel () and securing grooves (), wherein the flow element is characterized in that the capillary line () is arranged in the ring-shaped channel (). The ends of the capillary lines () are connected to connection elements () in which securing grooves () are secured in a positive locking manner. The flow elements according to the invention contribute toward improved manageability and effectiveness of components. In a preferred embodiment, the flow elements are used as a distribution system in the form of a plurality of capillary cartridges (-- . . . ). Such distribution systems are of technical importance in the field of catalyst testing apparatuses with reactors arranged in parallel. 1. A flow element , comprising:a capillary cartridge anda coiled capillary line,wherein the capillary cartridge comprises a ring-shaped channel and a securing element,in the flow element, the coiled capillary line is arranged in the ring-shaped channel,each end of the capillary line are is connected to a connection element, respectively, andthe connection element is fixed in place with two or more securing elements in a positive locking and/or non-positive locking manner.2. The flow element of claim 1 ,wherein the two or more securing elements are configured as securing grooves, which are an inlet-side securing groove and an outlet-side securing groove.3. The flow element of claim 2 ,wherein each of the inlet-side and outlet-side securing grooves accommodates an anti-rotation device of the connection element, andthe anti-rotation device has at least three corners, so that at least one edge of the anti-rotation device runs parallel to an edge of the inlet-side or outlet-side securing groove, so that a rotatability of the connection element about its longitudinal axis is ...

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Номер записи: 64

10-08-2017 дата публикации

GENERAL-PURPOSE RECONFIGURABLE CONDUIT AND REACTION CHAMBER MICROFLUIDIC ARRANGEMENTS FOR LAB-ON-CHIP AND MINIATURE CHEMICAL PROCESSING

Номер: US20170225163A1

Автор: Ludwig Lester F.

Принадлежит:

A general-purpose software-reconfigurable chemical process system useful in a wide range of applications is disclosed. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or small-scale chemical manufacturing. 1. A software controllable and software reconfigurable multipurpose embedded microfluidic chemical processor system , the system comprising:a plurality of controllable valves for controlling flows of chemical substances, wherein each of the plurality of controllable valves comprises a plurality of flow ports and a plurality of valve control connections, wherein at least one flow port of the plurality of flow ports of each controllable valve of the plurality of controllable valves is connected to at least one microfluidic conduit selected from a first plurality of microfluidic conduits and at least one microfluidic conduit selected from a second plurality of microfluidic conduits; a plurality of chemical interface ports for transporting the chemical substances, wherein each of the plurality of chemical interface ports is connected to an ...

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Номер записи: 65

18-07-2019 дата публикации

Dry Chemistry Container

Номер: US20190217292A1

Автор: CARRERA FABRA Jordi, Comengés Casas Anna, Engel Holger, Lee Diane Rachel, Lee Martin Alan, MARTÍN BLANCO Ricard

Принадлежит:

A microfluidic system is presented that includes a cartridge, a container, and a lid for the container. The cartridge includes a plurality of microfluidic channels coupled to one or more chambers. The container holds dry chemicals and includes a housing with a first opening and a second opening smaller than the first opening. The container is designed to be inserted into an opening of the cartridge, such that the container is independently secured within the opening. The insertion of the container allows for the container to be fluidically coupled with a microfluidic channel of the plurality of microfluidic channels via the second opening. The lid includes a column that extends from the lid into the container. 1. A microfluidic system , comprising:a cartridge having a plurality of microfluidic channels coupled to one or more chambers;a container configured to hold dry chemicals and having a housing with a first opening and a second opening smaller than the first opening, wherein the container is configured to be inserted into an opening of the cartridge, such that the container is independently secured within the opening of the cartridge and is fluidically coupled with a microfluidic channel of the plurality of microfluidic channels via the second opening of the container; anda lid configured to seal a first opening of the container, the lid comprising a column that extends from the lid into the container.2. The microfluidic system of claim 1 , wherein the housing has a first cylindrical portion and a second cylindrical portion smaller than the first cylindrical portion.3. The microfluidic system of claim 2 , wherein a diameter of the first cylindrical portion is substantially equal to a diameter of the first opening and a diameter of the second cylindrical portion is substantially equal to a diameter of the second opening.4. The microfluidic system of claim 2 , wherein the container further comprises one or more structures that protrude outward from the first ...

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Номер записи: 66

09-07-2020 дата публикации

FLOW DISTRIBUTOR

Номер: US20200215543A1

Автор: DERIDDER Sander, DESMET Gert, JESPERS Sander

Принадлежит:

A distributor is described for distributing a fluid flow from a smaller to a more broad fluid flow. It comprises a fluid input and a plurality of fluid outputs, and a channel structure in between the fluid input and the plurality of fluid outputs. The channel structure comprises alternatingly bifurcating channel substructures and common channel substructures wherein the substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure mixes in a subsequent common channel substructure, and whereby fluid channels of the bifurcating channel substructure are arranged such that these do not contact the subsequent common channel substructure at the edges thereof. 114.-. (canceled)15. A distributor for distributing a fluid flow from a smaller fluid plug to a more broad fluid plug ,said distributor comprising a fluid input and a plurality of fluid outputs, and a channel structure in between the fluid input and the plurality of fluid outputs,the channel structure comprising alternatingly bifurcating channel substructures and common channel substructures wherein said substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure mixes in a subsequent common channel substructure, andwhereby fluid channels of the bifurcating channel substructure are arranged such that these do not contact the subsequent common channel substructure at the edges thereof.16. The distributor according to claim 15 , wherein the common channel substructure is arranged such that its length axis is substantially perpendicular to a net forward flow of the structure and said edges of the common channel substructure correspond with the end points of the length axis.17. The distributor according to claim 15 , wherein at least one common channel substructure comprises a common channel filled with a plurality of pillar elements arranged spaced from each other.18. The distributor according to claim 17 , wherein the ...

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Номер записи: 67

09-07-2020 дата публикации

REACTOR INCORPORATING A HEAT EXCHANGER

Номер: US20200216313A1

Автор: Contini Vincent, George, Goshe Matthew E., II Paul E.

Принадлежит:

A reactor containing a heat exchanger is disclosed, which can be operated with co-current or counter-current flow. Also disclosed is a system that includes a reactor having a reformer and a vaporizer, a fuel supply, and a water supply. The reactor includes a source of combustion gas, a reformer operative to receive reformate, and a vaporizer operative to receive water. The reformer and vaporizer each include a stack assembly formed by a combination of separator shims and channel shims. The separator shims and channel shims are stacked in a regular pattern to form two sets of channels within the stack assembly. One set of channels will have vertical passageways at either end and a horizontal flowpath between them, while the other set of channels has only a horizontal flowpath. 1. A heat exchanger , comprising:a first channel having a flowpath, a first wall, a second wall opposite the first wall, an inlet manifold at a first end, and an outlet manifold at a second opposite end, the inlet manifold and the outlet manifold running orthogonal to the flowpath, and a mixing manifold within the first channel running orthogonal to the flowpath, wherein the first channel comprises a plurality of first micro-channels and the mixing manifold permits vertical mixing between first micro-channels; anda second channel having a flowpath parallel to the flowpath of the first channel, the first channel and the second channel being separated by the first wall.2. The heat exchanger of claim 1 , further comprising a fin extending from the second channel into the first channel claim 1 , the fin passing through the first wall and extending to the second wall;3. The heat exchanger of claim 1 , wherein the ratio of a first micro-channel width to a first micro-channel height is from 2:1 to 20:1.4. The heat exchanger of claim 1 , wherein the second channel comprises a plurality of second micro-channels.5. The heat exchanger of claim 1 , wherein the heat exchanger is formed from a channel shim ...

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Номер записи: 68

27-08-2015 дата публикации

Automated Radiopharmaceutical Production and Quality Control System

Номер: US20150238918A1

Автор: Aaron Mcfarland, Atilio Anzellotti, Clive Brown-Proctor, Doug Ferguson, Mark Khachaturian

Принадлежит: ABT MOLECULAR IMAGING INC

An automated radiopharmaceutical production and quality control system includes a particle accelerator, a radiopharmaceutical micro-synthesis subsystem, and quality control subsystem. The micro-accelerator of the improved biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in quantities on the order of multiple unit doses, allowing for significant reductions in size, power requirements, and weight when compared to conventional radiopharmaceutical cyclotrons. The radiopharmaceutical micro-synthesis subsystem encompasses a small volume chemical synthesis system comprising a microreactor and/or a microfluidic chip and optimized for synthesizing the radiopharmaceutical in small quantities, allowing for significant reductions in processing time and in the quantity of radioisotope required. The automated quality control subsystem is used to test the composition and characteristics of the radiopharmaceutical to ensure that it is safe to inject.

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Номер записи: 69

18-08-2016 дата публикации

METHOD AND DEVICE FOR CARRYING OUT A REACTION BETWEEN AT LEAST TWO REACTANTS

Номер: US20160236934A1

Автор: DITTMEYER Roland, Kraut Manfred, VANKAYALA Bhanu

Принадлежит:

A method for carrying out a reaction between at least two reactants in a liquid reaction solution in at least one reaction zone so as to produce a reaction product includes carrying out a reaction continuously in a reaction flow for the at least one reaction zone in an extension of the at least one reaction zone as far as at least one reaction product outlet, introducing each of the at least two reactants over the extension of the at least one reaction zone via inlets in which the reaction flow is introduced, and removing the reaction product via the at least one reaction product outlet. 1. A method for carrying out a reaction between at least two reactants in a liquid reaction solution in at least one reaction zone so as to produce a reaction product , the method comprising:a) carrying out the reaction continuously in a reaction flow for the at least one reaction zone in an extension of the at least one reaction zone as far as at least one reaction product outlet;b) introducing each of the at least two reactants over the extension of the at least one reaction zone via inlets in which the reaction flow is introduced; andc) removing the reaction product via the at least one reaction product outlet;wherein the at least two reactants are gaseous,wherein the inlets are spanned by sieve elements or membranes, andwherein the reactants are introduced in series and in an alternating manner into the reaction flow at each of the at least two inlets over the extension of the at least one reaction zone until saturation in the reaction solution is reached.2. The method according to claim 1 , wherein one of the at least two reactants is hydrogen and another of at least two reactants is oxygen claim 1 , andwherein the reaction product is hydrogen peroxide.3. The method according to claim 1 , wherein at least one catalyst material is dissolved or suspended in at least one of the reactants.4. A device for carrying out a continuous reaction between at least two reactants in a liquid ...

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Номер записи: 70

17-08-2017 дата публикации

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

Номер: US20170232440A1

Автор: Ismagilov Rustem F., Roach Lewis Spencer, Song Baca Helen, Tice Joshua David

Принадлежит:

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 120.-. (canceled)21. A method comprising:flowing a first plug fluid stream in a first microchannel toward a junction, the first plug fluid stream comprising a particle;flowing a second plug fluid stream in a second microchannel toward the junction, the second plug fluid stream comprising a biological element, wherein the first and second plug fluid streams meet at a first junction such that the particle and the biological element co-flow with each other downstream of the first junction toward a second junction; andflowing a carrier fluid that is immiscible with the first and second plug fluid streams to the second junction; andforming a plurality of plugs at the second junction, each of the plurality of plugs being separated by the carrier fluid and at least one of the plurality of plugs comprising the particle and the biological element.22. The method of claim 21 , wherein the carrier fluid is an oil.23. The method of claim 21 , wherein the particle and biological element within the at least one plug allow for a reaction to occur.24. The method of claim 23 , wherein the reaction is an autocatalytic reaction.25. The method of claim 24 , wherein the autocatalytic reaction is a polymerase-chain reaction (PCR).26. The method of claim 21 , wherein the biological element comprises a biological molecule.27. The method of claim 26 , wherein the biological molecule is DNA or RNA.28. The method of claim 26 , wherein the biological molecule is a protein.29. The method of claim 26 , wherein the biological molecule is secreted from a cell.30. The method of claim 26 , wherein the at least one plug comprises a single biological molecule.31. The method of claim 21 , wherein the particle is a microbead.32. The method of claim 21 , wherein at least one of the first and second plug fluids ...

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Номер записи: 71

17-08-2017 дата публикации

BLOCK COPOLYMER, AND METHOD FOR PREPARING GRAPHENE USING THE SAME

Номер: US20170233256A1

Автор: Chae Seung Yong, KWON Won Jong, Lee Mi Jin, Sohn Byeong-Hyeok, SOHN Kwon Nam

Принадлежит:

The present invention relates to a method for preparing graphene using a novel block copolymer. The present invention has features that, by using the block copolymer to mediate graphene that is hydrophobic and a solvent of a feed solution that is hydrophilic, the exfoliation efficiency of graphene as well as the dispersion stability thereof can be increased during high-pressure homogenization. 3. The block copolymer according to claim 2 , whereinX is a bond,{'sub': 1', '1-4, 'Ris hydrogen; or Calkyl, and'}{'sub': 2', '6-20, 'Ris a carboxy group; or Caryl substituted with a carboxyl group or a sulfonic acid group.'}4. The block copolymer according to claim 2 , whereinX is oxygen and{'sub': 1', '2, 'Rand Rare each independently hydrogen.'}5. The block copolymer according to claim 2 , wherein{'sub': 1', '2, 'Rand Rare each independently hydrogen; methyl; carboxy group; or phenyl substituted with a sulfonic acid group, and'}{'sub': 3', '4, 'Rand Rare each independently hydrogen; phenyl; naphthyl; pyrene-2-ylmethoxycarbonyl; or 4-(pyrene-2-yl)butoxycarbonyl.'}7. The block copolymer according to claim 1 , whereinthe ratio of n:m is 2-10:1.9. The block copolymer according to claim 8 , wherein{'sub': 2', '2, 'X′ is ethylene (—CH—CH—).'}10. The block copolymer according to claim 8 , wherein{'sub': 4', '2, 'Ris phenyl, naphthyl, or —COOCH-(pyrenyl).'}12. A method for preparing graphene claim 8 , comprising the step of passing a feed solution including graphite through a high-pressure homogenizer including an inlet claim 8 , an outlet claim 8 , and a micro-channel that connects between the inlet and the outlet and has a diameter in a micrometer scale claim 8 ,{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein the feed solution includes the block copolymer of .'}13. The method for preparing graphene according to claim 12 , whereingraphite in the feed solution is exfoliated while passing through a micro-channel under application of a shear force, thereby preparing a ...

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Номер записи: 72

25-07-2019 дата публикации

LAMINATED, LEAK-RESISTANT CHEMICAL PROCESSORS, METHODS OF MAKING, AND METHODS OF OPERATING

Номер: US20190224639A1

Автор: Deshmukh Soumitra, Keyes Lane W., Luzenski Robert J., Marchiando Michael A., Marco Jeffrey D., Marco Jennifer L., Neagle Paul W., Tonkovich Anna Lee, Yuschak Thomas

Принадлежит:

The invention provides methods of making laminated devices (especially microchannel devices) in which plates are assembled and welded together. Unlike conventional microchannel devices, the inventive laminated devices can be made without brazing or diffusion bonding; thus providing significant advantages for manufacturing. Features such as expansion joints and external welded supports are also described. Laminated devices and methods of conducting unit operations in laminated devices are also described. 121-. (canceled)22. A pressure-resistant substrate assembly , comprising:a welded laminate configured such that, during operation, flow of fluids through the laminate is primarily perpendicular to sheet thickness;wherein the laminate comprises a first layer adjacent to a second layer and a periphery around the first and second layers;wherein the periphery is perpendicular to sheet thickness;wherein the first layer comprises microchannels and wherein the second layer comprises channels and seals along the periphery, wherein the seals hold a differential pressure of more than 100 psig between the first layer and the second layer; andwherein the seals are not diffusion bonded or brazed.23. The pressure-resistant substrate assembly of wherein the seals hold a differential pressure of more than 500 psig between the first layer and the second layer.24. A welded pressure-resistant substrate assembly claim 22 , comprising:a plurality of channels that are sealed welding;wherein the sealing is not the result of polymeric gaskets, brazing, or diffusion bonding;and having a leak rate of less than 10 sccm nitrogen when pressurized with nitrogen gas at 100 psig and room temperature.25. The welded pressure-resistant substrate assembly of having a leak rate of less than 11 sccm nitrogen when pressurized with nitrogen gas at 100 psig and room temperature.25. The welded pressure-resistant substrate assembly of wherein the assembly comprises a plurality of sheets in a stack claim 24 , ...

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Номер записи: 73

03-09-2015 дата публикации

BURNER FOR THE PRODUCTION OF SYNTHESIS GAS

Номер: US20150247635A1

Автор: Humair Daniele, Zanichelli Luca

Принадлежит: Casale SA

A burner suitable for the over stoichiometric combustion of a hydrocarbon source, comprising a nozzle () for the formation of a diffusion flame outside the burner, and said nozzle () comprising one () or more () tubular bodies which define a channel () or a plurality of coaxial channels () for respective reactant streams, wherein the or each of the tubular bodies forming said nozzle () are made of a technical ceramic material. 1. A process burner suitable for the over stoichiometric combustion of a hydrocarbon source , the burner comprising a body and a nozzle associated to said body , wherein:said nozzle is arranged for the formation of a diffusion flame outside said process burner, said process burner has a feeding side with at least one inlet for a reactant stream, and an opposite end side with an outlet section which defines a boundary between a feeding region and a combustion region, the burner being configured in such a way that combustion take place downstream of said outlet section,said nozzle comprises at least one tubular body to define at least one channel for said reactant stream, ending at said outlet section of said nozzle, andsaid at least one tubular body is integrally made of a technical ceramic material, andsaid at least one reactant stream are confined by said at least one ceramic body until the reaching of said outlet section.2. The burner according to claim 1 , said at least one tubular body being made in a single piece.3. The burner according to claim 1 , said nozzle comprising a plurality of tubular bodies to define coaxial channels for respective reactant streams such as for example fuel and oxidant.4. The burner according to claim 1 , said technical ceramic material having a thermal conductivity of at least 10 W/(m K) claim 1 , and an elastic modulus of at least 40 GPa.5. The burner according to claim 4 , said technical ceramic material having at least one of the following properties:a thermal conductivity in the range 10 to 230 W/(m K), ...

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Номер записи: 74

23-08-2018 дата публикации

Fuel processor component for a propylene glycol fuel processor and propylene glycol fuel processor

Номер: US20180236431A1

Автор: David Tiemann, Gunther Kolb, Jochen Schuerer

Принадлежит: DIEHL AEROSPACE GMBH

The invention relates to a fuel processor component for a propylene glycol fuel processor, comprising at least one housing (G) having at least two inlets (E 1 , E 2 ) and two outlets (A 1 , A 2 ), wherein there is a multitude of first plates (P 1 ) having a first side (S 1 ) and a second side (S 2 ) and second plates (P 2 ) having a third side (S 3 ) and a fourth side (S 4 ) arranged as a stack in the housing (G), wherein the stacked first and second plates (P 1 , P 2 ) form at least first cavities (H 1 ) and second cavities (H 2 ), wherein the first inlet (E 1 ) has fluid connection to the first outlet (A 1 ) via first cavities (H 1 ) and the second inlet (E 2 ) has fluid connection to the second outlet (A 2 ) via second cavities (H 2 ). The invention further relates to a propylene glycol fuel processor.

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Номер записи: 75

15-09-2016 дата публикации

Micro-channel reactor

Номер: US20160263546A1

Автор: Jae Hoon Choe, Seokhyun Yoon, Taehun Yoon, Young Chang Byun

Принадлежит: LG Chem Ltd

Disclosed herein is a micro-channel reactor formed by placing a planar upper plate and a planar lower plate, each having a channel formed therein, such that the upper plate and the lower plate face each other, wherein the channel includes one or more introduction channels, into which different fluids are introduced respectively, a mixing channel, along which the fluids introduced into the introduction channels flow in a state in which the fluids join each other, and a discharge channel, from which the fluids joining in the mixing channel are discharged, the mixing channel includes a stem channel extending from the introduction channels to the discharge channel and one or more branch channels that diverge from the stem channel and are then interrupted, and, when the fluids are mixed through repetitive diverging and joining, the fluids diverge in upward and downward directions and then join each other in leftward and rightward directions.

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Номер записи: 76

15-08-2019 дата публикации

IMPROVEMENTS IN OR RELATING TO A FLUID FLOW CONTROLLER FOR MICROFLUIDIC DEVICES

Номер: US20190247855A1

Автор: DOUGLAS Anthony, Knowles Tuomas Pertti Jonathan, Lyn Andrew, Mueller Thomas

Принадлежит: Fluidic Analytics Limited

A fluid flow controller for introducing fluids into a microfluidic device is provided. The fluid flow controller comprising, at least one high resistance fluid pathway provided between an inlet port and a connection port; at least one low resistance fluid pathway between the inlet and connection port; and at least one valve configured to enable fluid flow through the high resistance fluid pathway, the low resistance fluid pathway or both. 1. A fluid flow controller for introducing fluids into a microfluidic device , the controller comprising:a first fluid pathway provided between an inlet port and a connection port;a second fluid pathway between the inlet and connection port;wherein the resistance of the second resistance fluid pathway is at least 10 times less than the resistance of the first resistance fluid pathway; andwherein the controller further comprises at least one valve configured to enable fluid flow through the second fluid pathway.2. The controller according to claim 1 , wherein the resistance of the first and second fluid pathway is dictated by one or more of the following: the cross sectional area of the pathway claim 1 , the length of the pathway and the surface roughness of the pathway.3. The controller according to claim 1 , wherein the first fluid pathway is one pathway within a network of pathways linking one or more inlet ports to one or more connection ports.4. The controller according to claim 3 , wherein each first fluid pathway has a corresponding second fluid pathway.5. The controller according to claim 1 , wherein a plurality of first fluid pathways and a plurality of second fluid pathways are provided in an array.6. The controller according to claim 5 , further comprising a manifold including a plurality of valves for controlling the array of fluid pathways.7. The controller according to claim 1 , wherein the resistance of the second fluid pathway is at least three times less than the resistance of the first fluid pathway.8. (canceled)9. ...

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Номер записи: 77

06-08-2020 дата публикации

IMPROVED PROCESS-INTENSIFIED FLOW REACTOR

Номер: US20200246772A1

Автор: Jean Patrick, Lavric Elena Daniela

Принадлежит:

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion. 1. A flow reactor comprising: (1) an input end at which process fluid is to flow into the portion during use and', '(2) an output end at which process fluid is to flow out of the portion during use, and', '(3) a cross section along the portion delimited by the interior surface of the passage along the portion, the cross section having a cross-sectional area and a cross-sectional shape, the cross-sectional area having multiple minima along the passage between the input end and the output end, the passage characterized in that (1) the cross-sectional shape of the portion varies continually along the portion, (2) the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion, and (3) the portion contains a plurality of obstacles positioned along the portion between the input end and the output end., 'a module having a process fluid passage therein, the process fluid passage comprising an interior surface, the process fluid passage further comprising a portion thereof which portion further comprises2. The flow reactor according to wherein the portion further comprises successive chambers each with a nozzle-like entrance and a ...

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Номер записи: 78

22-08-2019 дата публикации

PROCESS AND SYSTEM FOR PRODUCING PULP, ENERGY, AND BIODERIVATIVES FROM PLANT-BASED AND RECYCLED MATERIALS

Номер: US20190255506A1

Автор: Barla Florin, Bobe Iulian, Kostenyuk Igor, Kumar Sandeep, Majeranowski Peter

Принадлежит:

The presently disclosed subject matter relates to an industrial system for processing various plant materials to produce marketable materials. Particularly, the system integrates subcritical water extraction technology and includes a pre-processing module and a two-stage extractor (processing module) with constant control of temperature, pressure, and/or residence time. In some embodiments, the final product of the disclosed system can include feedstock constituents for biofuel production (sugars and/or oil), biochar, raw materials for various industries (such as pulp for manufacturing paper or cellulose for use in various industries). The disclosed system can be modular or non-modular, stationary or mobile, and can include prefabricated elements with programmed automatic or manual operation so that it can be easily moved and/or assembled on site. 1. (canceled)2. A system comprising:a pre-processing portion having a mechanical processor/material handler for a preparation of feedstock material; andan extractor portion comprising a reactor or a reactor assembly to which feedstock and subcritical water is supplied, the reactor or reactor assembly having:a first operating condition at a first pressure and a first temperature at a constant level that is held for a first defined period of time to break down carbohydrates of a first chain strength,wherein the reactor assembly comprises an assembly of one or more reactors followed by one or more pressure control valves, heat exchangers for cooling down the outputs from the reactor, and separators to collect valuable materials from the water phase and consequently recycle the water.3. The system of claim 2 , wherein the reactor assembly comprises continuous-type reactors or batch-type reactors.4. The system according to claim 2 , further including:a high pressure pump for increasing a pressure in the system, wherein a variable speed and flow rate are provided;a pressure control valve for maintaining pressure in the first ...

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Номер записи: 79

20-09-2018 дата публикации

MICROFLUIDIC METHODS FOR PASSIVE SEPARATION OF CELLS AND PARTICLES

Номер: US20180264473A1

Автор: Papautsky Ian, Zhou Jian

Принадлежит:

A method of separating a plurality of particles () from a portion of fluid, comprising directing the plurality of particles () into a microchannel (). A first portion () of particles () is focused into an equilibrium position in the microchannel (). The focused first portion () is directed into a first outlet () aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (). A microfluidic device () for separating a plurality of particles () from a portion of fluid, comprising a microchannel () having a first aspect ratio and a length L, thereby focusing the particles () directed therein into an equilibrium position in the microchannel, wherein at least a first portion () of the particles () focuses at distance X from a beginning of the microchannel (). A first outlet () disposed after distance X and aligned with the equilibrium position to receive at least the first portion () of the particles () after the first portion () focuses into an equilibrium position in the microchannel (). At least a second outlet () for receiving a second portion of the particles () before the second portion focuses into an equilibrium position. 1. A microfluidic device for separating a plurality of particles from a fluid medium , comprising:{'sub': '1', 'a microchannel having a first aspect ratio and a length Lin order to allow the particles directed therein to focus into a first equilibrium position in the microchannel, and'} a first capture portion having a first chamber outlet, the first chamber outlet being separated from the microchannel by a first wall,', 'a second capture portion symmetric with the first capture portion, the second capture portion having a second chamber outlet, the second chamber outlet being separated from the microchannel by a second wall,', 'a main outlet in a third wall opposite the first and second walls, and', 'a main flow area in the chamber between the microchannel and main outlet, the main flow area also defined as ...

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Номер записи: 80

11-12-2014 дата публикации

MICROCHANNEL COMPRESSION REACTOR

Номер: US20140364518A1

Автор: Forte Thomas Peter, JR. William Allen, Litt Robert Dwayne, Miele Charles Robert, Pasadyn Ronald Chester, Pelham Jimmy Glen, Rogers, Smith George Bradley, Weil Christopher Paul

Принадлежит:

A method of starting up one or more units, the method comprising the steps of: (a) starting up a first unit including a microchannel reactor housing a Fischer-Tropsch catalyst by initially feeding a carbon monoxide source and a hydrogen source to the first unit and through the microchannel reactor; (b) processing, within the microchannel reactor, at least a portion of the carbon monoxide source and the hydrogen source; (c) monitoring at least one of internal pressure, temperature, and concentration at least one of within the microchannel reactor and downstream from the microchannel reactor; (d) at least partially containing the microchannel reactor using a wall of a containment device, the wall cooperating with the microchannel reactor to delineate at least one of a first inlet cavity and a first outlet cavity of the microchannel reactor, where at least one of the first inlet cavity and the first outlet cavity is not in fluid communication with at least one of a second inlet cavity and a second outlet cavity; and, (e) using the containment device to reinforce the integrity of the microchannel reactor. 1. A method of starting up one or more units , the method comprising the steps of:starting up a first unit including a microchannel reactor housing a Fischer-Tropsch catalyst by initially feeding a carbon monoxide source and a hydrogen source to the first unit and through the microchannel reactor;processing, within the microchannel reactor, at least a portion of the carbon monoxide source and the hydrogen source;monitoring at least one of internal pressure, temperature, and concentration at least one of within the microchannel reactor and downstream from the microchannel reactor;at least partially containing the microchannel reactor using a wall of a containment device, the wall cooperating with the microchannel reactor to delineate at least one of a first inlet cavity and a first outlet cavity of the microchannel reactor, where at least one of the first inlet cavity ...

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Номер записи: 81

09-12-2021 дата публикации

Microscale Chemical Reactors

Номер: US20210379556A1

Автор: Shafer Daniel

Принадлежит:

A catalytic microscale reactor with spiral reactor geometry may have a high surface area to volume ratio, high catalytic surface area, high heat transfer surface area, long residence time, and high single pass conversion. The catalytic surface may be treated with micro sphere spacer particles which serve to maintain the space between them at an engineered distance without the need for precise manufacturing techniques. The design of the reactor may allow for a catalyst surface to be removed, uncoiled, refurbished, and recoiled in an automated continuous process. An automated continuous process may be suitable both for initially preparing a new catalytic surface as well as refurbishing a fouled catalytic surface and may the time and cost to prepare a new surface. 1. A method of producing a reactive component comprising continuously feeding a substrate past a first processing apparatus , wherein the first processing apparatus deposits a reactive substance on the substrate.2. The method of further comprising continuously feeding the substrate past a second processing apparatus claim 1 , wherein the second processing apparatus prepares a surface of the substrate to receive the reactive substance.3. The method of wherein the reactive coating comprises a catalytic coating.4. The method of wherein the reactive coating comprises a biofilm.5. The method of wherein the substrate has previously been used as part of a reactive component.6. The method of further comprising applying spacers to the substrate.7. A method of continuously producing a catalytic surface comprising:obtaining a metallic substrate rolled into a first coil;placing the coil onto a first real;rolling the metallic substrate through a first phase which sands the surface of the metallic substrate;rolling the metallic substrate through a second phase cleaning the surface of the metallic substrate;rolling the metallic substrate through a third phase depositing spacer particles onto the surface of the metallic ...

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Номер записи: 82

06-10-2016 дата публикации

DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION

Номер: US20160288124A1

Автор: Gerdts Cory John, Ismagilov Rustem F., Tice Joshua David, Zheng Bo

Принадлежит:

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. 115.-. (canceled)16. A method for obtaining a collection of plugs comprising at least one biological molecule and at least one or more chemical reactants for conducting a reaction with the biological molecule , the method comprising the steps of:providing a microfluidic system comprising at least a first and second channel, the first and second channels configured to intersect with each other at a junction, and an outlet adapted for receiving a segment of tubing or a sample tube;continuously flowing an aqueous fluid containing the at least one biological molecule and the at least one or more reagents for conducting the reaction with the biological molecule, through the first channel;continuously flowing a carrier fluid immiscible with the aqueous fluid through the second channel;forming a plurality of the plugs of the aqueous fluid containing the at least one biological molecule and the at least one or more reagents for conducting the reaction with the biological molecule, by partitioning the aqueous fluid with the flowing immiscible carrier fluid at the junction of the first and second channels, the plugs being substantially surrounded by the immiscible carrier fluid flowing through the channel, wherein at least one of the plurality of the plugs comprises the at least one biological molecule and the at least one or more reagents for conducting the reaction with the biological molecule; andcollecting the plurality of the plugs in the segment of tubing or the sample tube, wherein the plugs remain separated by the carrier immiscible fluid.17. The method according to claim 16 , wherein the immiscible carrier fluid is an oil.18. The method according to claim 17 , wherein the oil comprises a surfactant.19. The method according to claim 18 , wherein the surfactant is a ...

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Номер записи: 83

12-11-2015 дата публикации

Micro Blood Vessels and Tissue Ducts

Номер: US20150322408A1

Автор: Andre A. Adams, Frances S. Ligler, Michael Daniele

Принадлежит: US Department of Navy

A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.

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Номер записи: 84

01-11-2018 дата публикации

RECONFIGURABLE CHEMICAL SYNTHESIS SYSTEMS AND METHODS

Номер: US20180311638A1

Автор: III Dale Arlington, Jensen Klavs F., Thomas

Принадлежит: Massachusetts Institute of Technology

Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections). According to some embodiments, in order to avoid tangling the flexible conduits during reconfiguration of the system, the fluidic connections are disconnected according to certain inventive methods described herein. In certain embodiments, fluidic connections are disconnected in reverse order relative to the order in which they were formed (e.g., the newest fluidic connection is disconnected first, the oldest fluidic connection is disconnected last). In certain embodiments, certain fluidic connections are targeted for disconnection, and additional fluidic connections are disconnected if they overlap the targeted fluidic connections and were formed more recently than the targeted fluidic connections. The fluidic connection and/or disconnection steps may, in some embodiments, be performed by a robotic manipulator. 1. A fluidic system , comprising:a first plurality of fluid outlets;a first plurality of fluid inlets; anda first fluid connector unit comprising a first ...

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Номер записи: 85

10-10-2019 дата публикации

METHOD FOR DEPOSITING A CATALYST ON THE INNER SURFACE OF THE MICROCHANNELS OF A REACTOR-EXCHANGER

Номер: US20190308160A1

Автор: CROISSANT Baptiste, Faure Raphael, JOLY Romain, Rossignol Fabrice

Принадлежит:

A process for the deposition of a catalyst in an exchanger-reactor including an inlet, an outlet, and microchannels, the microchannels including an internal surface, the process including positioning the exchanger-reactor in a vertical position, wherein the inlet and the outlet are in a plane perpendicular to a horizontal plane and, wherein the inlet and outlet are below the microchannels, introducing a catalyst in suspension into the exchanger-reactor via the inlet by means of a pump, filling the exchanger-reactor with the catalyst in suspension at a rate of between 5 and 20 ml/min, and emptying the exchanger-reactor, thereby depositing at least a portion of the catalyst on the internal surface. 19-. (canceled)10. A process for the deposition of a catalyst in an exchanger-reactor comprising an inlet , an outlet , and microchannels , the microchannels comprising an internal surface , the process comprising:positioning the exchanger-reactor in a vertical position, wherein the inlet and the outlet are in a plane perpendicular to a horizontal plane and, wherein the inlet and outlet are below the microchannels,introducing a catalyst in suspension into the exchanger-reactor via the inlet by means of a pump,filling the exchanger-reactor with the catalyst in suspension at a rate of between 5 and 20 ml/min, andemptying the exchanger-reactor, thereby depositing at least a portion of the catalyst on the internal surface.12. The process of claim 10 , wherein the filling is carried out until a level lower by at least 5 mm than the junction between the reactive channels and the product channels is reached.13. The process of claim 10 , wherein the pump operates within a range of flow rates extending from 5 ml/min to 2500 ml/min.14. The process of claim 10 , wherein the filling is controlled using a gauge.15. The process of claim 14 , wherein the gauge is vertical and parallel to the exchanger-reactor.16. The process of claim 10 , wherein the catalyst in suspension is kept stirred ...

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Номер записи: 86

01-10-2020 дата публикации

Scale-up of microfluidic devices

Номер: US20200306706A1

Автор: Adam R. Abate, David A. Weitz, Mark Romanowsky

Принадлежит: Harvard College

Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

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Номер записи: 87

08-11-2018 дата публикации

Scalable chemical reactor and method of operation thereof

Номер: US20180320280A1

Автор: Patrick Ruch, Werner Escher

Принадлежит: International Business Machines Corp

A photovoltaic apparatus comprising: at least one photovoltaic surface electrically connected to a set of photovoltaic electrodes; and a chemical reactor electrically connected to the set of photovoltaic electrodes. The chemical reactor enables N pairwise fluid contacts among k chemical fluids, with k≥2 and N≥4 and comprises: a reaction layer extending in a plane subtended by two directions; N chemical cells, each including two circuit portions, designed for enabling circulation of two of the k chemical fluids, respectively, the two circuit portions intersecting each other, thereby enabling one pairwise fluid contact for the two of the k chemical fluids; and a fluid distribution circuit comprising: k sets of inlet orifices sequentially alternating along lines parallel to one of the two directions; and k sets of outlet orifices sequentially alternating along lines parallel to the inlet orifices, and wherein, each circuit portion connects an inlet orifice to an outlet orifice.

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Номер записи: 88

08-10-2020 дата публикации

FLOW REACTOR FLUID CONNECTION APPARATUS AND METHOD

Номер: US20200316554A1

Автор: Gremetz Sylvain Maxime F

Принадлежит:

A flow reactor [] includes a fluidic module [] having an external surface [], an internal process fluid path [], and an input port [I] and an output port [O] connected to the process fluid path []. An upstream coupler [] is connected to the input port [I], and a downstream coupler [] is connected to the output port [O]. The upstream coupler [] has a gasket [] in a gasket groove [] pressed against the fluidic module [] and a hollow circular cylindrical post [] protruding from the upstream coupler [] and extending into the input port [I]. The downstream coupler [] has a gasket [] in a gasket groove [] pressed against the fluidic module [] and no hollow circular cylindrical post extending into the output port [O]. 1. A flow reactor comprising:a fluidic module having an external surface, an internal process fluid path, and an input port and an output port each in the form of an opening in the external surface, the process fluid path extending from the input port to the output port;an upstream coupler connected to the input port, the upstream coupler comprising an upstream coupler body having an upstream gasket, the upstream gasket pressed against the external surface of the fluidic module by an upstream coupler face of the upstream coupler body, the upstream gasket surrounding the input port; anda downstream coupler connected to the output port, the downstream coupler comprising a downstream coupler body and a downstream gasket, the downstream gasket pressed against the external surface of the fluidic module by a downstream coupler face of the downstream coupler body, the downstream gasket surrounding the output port;wherein the upstream coupler body comprises an upstream gasket groove in the upstream coupler face holding the upstream gasket and a hollow circular cylindrical post protruding from the upstream coupler face and extending into the input port, and wherein the downstream coupler body comprises a downstream gasket groove in the downstream coupler face holding ...

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Номер записи: 89

08-10-2020 дата публикации

MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE

Номер: US20200317453A1

Автор: Bunner Bernard, Deshpande Manish, Gilbert John R.

Принадлежит:

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip. 1. A microfabricated sheath flow structure for suspending a stream of particles in a sheath fluid , comprising:a primary sheath flow channel for conveying a sheath fluid, wherein the primary sheath flow channel has a width and a height;a sample inlet intersecting the primary sheath flow channel at a sample injection site for injecting a stream of particles into the sheath fluid conveyed through the primary sheath flow channel;a primary focusing region downstream of the sample injection site that focuses the stream of particles in at least a vertical direction; anda secondary focusing region downstream of the primary focusing region that focuses the stream particles in at least a horizontal direction.2. The microfabricated sheath flow structure of claim 1 , wherein the primary focusing region further focuses in a horizontal direction.3. The microfabricated sheath flow structure of claim 1 , wherein the secondary focusing region further focuses in a vertical direction.4. The microfabricated sheath flow structure of claim 1 , wherein a height of the primary sheath flow channel is reduced in the primary focusing region to produce the vertical focusing.5. The microfabricated sheath flow structure of claim 3 , wherein a height of the primary sheath ...

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Номер записи: 90

15-11-2018 дата публикации

MICROSCALE-BASED CHEMICAL REACTOR

Номер: US20180326390A1

Автор: Atadana Frederick, Jovanovic Goran Nadezda

Принадлежит: PTT PUBLIC COMPANY LIMITED

Disclosed microscale reactors comprise lamina for carrying out multi-phase reactions for making desired chemical products, such as biohydrogenated diesel (BHD). Microreactor embodiments include a bottom clamp plate, a top clamp plate, and at least one catalyst plate positioned between and operatively associated with the bottom clamp plate and the top clamp plate. Catalyst plates include a catalyst associated for catalyzing the production of product from feedstock. To address the problems encountered when using microchannel reactors, the microscale-based reactors may include a mixer plate assembly and/or at least one catalyst lamina comprising an array of microscale posts. Disclosed microreactor systems for producing BHD include a feedstock source, a hydrogen source and an inert gas source each fluidly coupled to respective microreactor inlets. Certain method embodiments include operating a microreactor or a microreactor system to produce BHD from a suitable feedstock selected from animal fats, vegetable oils, or combinations thereof. 166-. (canceled)67. A microreactor , comprising:a bottom clamp plate; a top clamp plate;a catalyst plate positioned between and operatively associated with the bottom clamp plate and the top clamp plate, the catalyst plate comprising a catalyst associated therewith for catalyzing the production of biohydrogenated diesel (BHD) from a suitable feedstock; anda mixer plate assembly,wherein at least one of the bottom clamp plate, the top clamp plate and the catalyst plate includes a feedstock inlet port for receiving a flow of feedstock, a hydrogen input port for receiving a flow of hydrogen for mixing with the feedstock, and an exit port for receiving a flow of BHD produced by the microreactor,wherein the catalyst plate comprising a plurality of microposts sized, shaped and positioned to disrupt a phase interface between liquid and gaseous reactants to create reaction zones.68. The microreactor according to claim 67 , wherein the bottom ...

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Номер записи: 91

24-10-2019 дата публикации

DROPLET-BASED MICROREACTORS FOR NANOPARTICLES

Номер: US20190321895A1

Автор: SANTANA Joshua S., Skrabalak Sara E.

Принадлежит:

Different Au—Pd nanoparticles, ranging from sharp-branched octopods to core@shell octahedra, can be achieved by inline manipulation of reagent flowrates in a microreactor for seeded growth. Significantly, these structures represent different kinetic products, demonstrating an inline control strategy toward kinetic nanoparticle products that should be generally applicable. 1. A microreactor comprising:a plurality of syringes, each syringe placed on a syringe pump;tubing connected to each syringe;capillaries connected to the tubing, an end of the capillaries meeting at an injector site of a respective syringe; anda heating element, the tubing positioned in the heating element to heat the tubing, wherein droplets from the tubing are collected in a centrifuge vial after exiting the tubing.2. The microreactor of claim 1 , wherein the plurality of syringes includes four syringes.3. The microreactor of claim 2 , wherein three of the four syringes contain reagents and one of the syringes contains silicone oil.4. The microreactor of claim 3 , wherein a flowrate of a reagent through the tubing is 1.8 mL per hour.5. The microreactor of claim 3 , wherein a first reagent includes H2PdCl4.6. The microreactor of claim 5 , wherein a second reagent includes Au nanocubes.7. The microreactor of claim 6 , wherein a third reagent includes L-aa.8. The microreactor of claim 1 , wherein:the tubing includes polytetrafluoroethylene; andthe capillaries include silica capillaries.9. The microreactor of claim 1 , wherein the tubing has an inner diameter of approximately 1.58 millimeters.10. The microreactor of claim 1 , wherein the capillaries have an inner diameter of approximately 0.250 millimeters.11. The microreactor of claim 1 , wherein the heating element has a temperature of approximately 55° C.12. A method for nanoparticle synthesis comprising:placing a plurality of syringes on a syringe pump;connecting tubing to each syringe;connecting capillaries to the tubing so that ends of the ...

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Номер записи: 92

15-11-2018 дата публикации

METHOD OF PREPARING CORE-SHELL PARTICLES

Номер: US20180331355A1

Автор: CHOI Gyeong Rye, HONG Jong Pal, Hwangbo Geun, Song Jung Hoon

Принадлежит:

A method of manufacturing core-shell particles comprises: filling a buffer into a rotor, which is extended in a longitudinal direction, and is accommodated so as to be spaced apart from an inner wall side of a non-rotational hollow cylinder extended in a longitudinal direction and then discharging air to outside; rotating the rotor after terminating the filling; forming a core-shell precursor by supplying raw materials from a first storage and a second storage, which comprise a material forming a core, into an interior of the cylinder in which the rotor rotates; supplying a shell material for coating the core to the interior of the cylinder in which a core-type precursor is formed; separating a liquid comprising core-shell particles formed through the supplying into a solid and a liquid; and drying the core-shell particles obtained through the separating. 1. A method of manufacturing core-shell particles , the method comprising:filling a buffer into a rotor, which is extended in a longitudinal direction, and is accommodated so as to be spaced apart from an inner wall side of an non-rotational hollow cylinder extended in a longitudinal direction and then discharging air to outside;rotating the rotor after terminating the filling;forming a core-shell precursor by supplying raw materials from a first storage and a second storage, which comprise a material forming a core, into an interior of the cylinder in which the rotor rotates;supplying a shell material for coating the core to the interior of the cylinder in which a core-type precursor is formed;separating a liquid comprising core-shell particles formed through the supplying into a solid and a liquid; anddrying the core-shell particles obtained through the separating.2. The method according to claim 1 , wherein as the liquid comprising the core-shell particles separated at the separating claim 1 , a reactant in a normal state within the reactor is used.3. The method according to claim 1 , wherein lithium chloride ...

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Номер записи: 93

10-12-2015 дата публикации

COMPOSITE GRANULES OF WHITE LIGHT QUANTUM DOTS, AND MANUFACTURE METHODS, MANUFACTURE DEVICES THEREOF

Номер: US20150353820A1

Автор: Gu Jingxia, TANG Chen, Wang Xuelan

Принадлежит: BOE Technology Group Co., Ltd.

Composite granules of white light quantum dots and manufacture methods, manufacture devices thereof with improved stability and quantum efficiencies of quantum dots materials. The composite granules of white light quantum dots comprise: main body of the granules (), which is a polymer obtained from light-polymerization of photoinitiator(s) and polymerizable component(s) under ultra-violet irradiation; red light quantum dots (), green light quantum dots () and blue light quantum dots () dispersed in the main body of the granules, wherein the concentrations of the red light quantum dots (), green light quantum dots () and blue light quantum dots () are different. 1. Composite granules of white light quantum dots , which comprise:main body of the granules which is a polymer obtained from light-polymerization of photoinitiator(s) and polymerizable component(s) under ultra-violet irradiation; andred light quantum dots, green light quantum dots and blue light quantum dots dispersed in the main body of the granules, wherein the concentrations of the red light quantum dots, the green light quantum dots and the blue light quantum dots are different.2. The composite granules of white light quantum dots according to claim 1 , wherein claim 1 ,the ratio between the red light quantum dots, the green light quantum dots and the blue light quantum dots is about 0.5˜0.8:1:1.5˜1.2.3. The composite granules of white light quantum dots according to claim 2 , wherein claim 2 ,the ratio between the red light quantum dots, the green light quantum dots and the blue light quantum dots is about 0.65˜0.74:1:1.35˜1.25.4. The composite granules of white light quantum dots according to claim 1 , wherein claim 1 ,the emission wavelength range of the red light quantum dots is from about 600 to about 685 nm; the emission wavelength range of the green light quantum dots is from about 520 to about 580 nm; and the emission wavelength range of the blue light quantum dots is from about 425 to about 485 ...

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Номер записи: 94

22-10-2020 дата публикации

SYNTHESIS GAS CONVERSION PROCESS

Номер: US20200332199A1

Автор: Deshmukh Soumitra R., Harris Roger A., Kennedy Paul E., Litt Robert Dwayne, Perry Steven T., Schrader Lucas D., Steynberg Andre P.

Принадлежит:

The disclosed invention relates to a method for restarting a synthesis gas conversion process which has stopped. The synthesis gas conversion process may be conducted in a conventional reactor or a microchannel reactor. The synthesis gas conversion process may comprise a process for converting synthesis gas to methane, methanol or dimethyl ether. The synthesis gas conversion process may be a Fischer-Tropsch process. 123-. (canceled)24. A method for restarting a synthesis gas conversion process , wherein the synthesis gas conversion process comprises flowing synthesis gas into a reactor in contact with a synthesis gas conversion catalyst at a desired reaction temperature and pressure to produce a synthesis gas conversion product and flowing effluent comprising the synthesis gas conversion product out of the reactor , the method comprising:(A) stopping the flow of synthesis gas into the reactor;(B) flowing natural gas into the reactor to purge the reactor; and(C) restarting the flow of synthesis gas into the reactor.25. The method of wherein the synthesis gas comprises CO and prior to stopping the flow of synthesis gas into the reactor the conversion of CO is at a desired conversion value claim 24 , and after restarting the flow of synthesis gas into the reactor the conversion of CO at the desired conversion value is achieved within a time period of up to about 3 hours.2629-. (canceled)30. The method of wherein the reactor comprises a fixed bed reactor claim 24 , a fluidized bed reactor or a slurry phase reactor.31. The method of wherein the reactor comprises a conventional reactor.32. The method of wherein the reactor comprises a microchannel reactor.33. The method of wherein the synthesis gas conversion process comprises a process for converting synthesis gas to methane.34. The method of wherein the synthesis gas conversion process comprises a process for converting synthesis gas to methanol or dimethyl ether.35. The method of wherein the synthesis gas conversion ...

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Номер записи: 95

29-10-2020 дата публикации

Fluid flow-passage device

Номер: US20200338546A1

Автор: Koji Noishiki, Tomohiro Ozono, Yutaka Yagi

Принадлежит: Kobe Steel Ltd

Provided is a fluid flow-passage device in which the flow passage length of each of a plurality of fluid flow-passages can be increased even if the plurality of fluid flow-passages are formed so as to extend in parallel to each other, and in which the inside of each of the plurality of fluid flow-passages can be easily cleaned. In the fluid flow-passage device, a plurality of fluid flow-passages which extend in parallel to each other and through which a fluid is made to flow are disposed. The fluid flow-passage device comprises: a body having a plurality of substrates that are laminated in a prescribed lamination direction; and a plurality of lids, each of which can be attached to and detached from the body. Each of the plurality of fluid flow-passages includes: a first fluid flow-passage that is disposed between two substrates among the plurality of substrates, the two substrates being in contact with each other in the lamination direction; and a second fluid flow-passage that is disposed between two substrates among the plurality of substrates, the two substrates being in contact with each other in the lamination direction and being disposed at a different position in the lamination direction from the first fluid flow-passage, and that is positioned more toward the downstream side than the first fluid flow-passage in the direction in which the fluid flows.

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Номер записи: 96

15-12-2016 дата публикации

Synthesis gas conversion process

Номер: US20160362611A1

Автор: Andre P. Steynberg, Deshmukh R. Soumitra, Lucas D. Schrader, Paul E. Kennedy, Robert Dwayne Litt, Roger A. Harris, Steven T. Perry

Принадлежит: Velocys Inc

The disclosed invention relates to a method for restarting a synthesis gas conversion process which has stopped. The synthesis gas conversion process may be conducted in a conventional reactor or a microchannel reactor. The synthesis gas conversion process may comprise a process for converting synthesis gas to methane, methanol or dimethyl ether. The synthesis gas conversion process may be a Fischer-Tropsch process.

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Номер записи: 97

14-12-2017 дата публикации

Countercurrent heat exchanger/reactor

Номер: US20170356693A1

Автор: John C. Davis, Lalit Chordia

Принадлежит: Thar Energy LLC

Counter-flow heat exchanger is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

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Номер записи: 98

14-11-2019 дата публикации

SYNTHESIS GAS CONVERSION PROCESS

Номер: US20190345394A1

Автор: Deshmukh Soumitra R., Harris Roger A., Kennedy Paul E., Litt Robert Dwayne, Perry Steven T., Schrader Lucas D., Steynberg Andre P.

Принадлежит:

The disclosed invention relates to a method for restarting a synthesis gas conversion process which has stopped. The synthesis gas conversion process may be conducted in a conventional reactor or a microchannel reactor. The synthesis gas conversion process may comprise a process for converting synthesis gas to methane, methanol or dimethyl ether. The synthesis gas conversion process may be a Fischer-Tropsch process. 1102-. (canceled)103. A method for restarting a synthesis gas conversion process , wherein the synthesis gas conversion process comprises flowing synthesis gas into a reactor in contact with a synthesis gas conversion catalyst at a desired reaction temperature and pressure to produce a synthesis gas product and flowing effluent comprising the synthesis gas conversion product out of the reactor , the method comprising:(A) stopping the flow of the synthesis gas into the reactor;(B) flowing hydrogen or natural gas into the reactor to purge the reactor; and(C) restarting the flow of synthesis gas into the reactor.104. The method of wherein the reactor is a conventional reactor.105. The method of wherein the reactor is a microchannel reactor.106. The method of wherein prior to step (A) the pressure within the reactor is at a pre-stoppage pressure claim 103 , and during step (A) the pressure within the reactor is reduced to a level lower than the pre-stoppage pressure claim 103 , and prior to step (B) the pressure within the reactor is increased to the pre-stoppage pressure.107. The method of wherein the catalyst is rejuvenated using hydrogen during step (B).108. The method of wherein during step (B) hydrogen flows into the reactor in contact with the catalyst at a temperature of up to 400° C. claim 103 , then air flows into the reactor in contact with the catalyst at a temperature in the range from 70° C. to 350° C. for a period of time in the range from 1 to 24 hours claim 103 , then hydrogen flows into the reactor in contact with the catalyst at a ...

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Номер записи: 99

21-12-2017 дата публикации

Methods and devices for the preparation of nanomaterials

Номер: US20170361299A1

Автор: Aamena Parulkar, Nicholas Brunelli

Принадлежит: Ohio State Innovation Foundation

Disclosed herein are methods for preparing nanomaterials, such as nanoparticles. The methods can involve jet-mixing two or more precursor solutions to form the nanomaterials. By rapidly mixing the precursor solutions, nanomaterials of improved quality and uniformity can be prepared in high yield (e.g., in yields of at least 85%). The methods are also scalable, and allow for the continuous production of nanomaterials. Also provided are jet-mixing reactors that can be used to prepare nanomaterials using the methods described herein.

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Номер записи: 100