Mikroreaktorsystem

Gegenstand der vorliegenden Erfindung ist die Sicherstellung einer Produktion mit sehr hoher Geschwindigkeit und hoher Effizienz unter Verwendung von Mikroreaktoren und die Erleichterung des Übergangs von der Synthese im Labormaßstab zur industriellen Produktion. Ein Mikroreaktorsystem, bei dem eine Mischlösung, die durch Zusammenmischen von Materiallösungen in einem Mikroreaktor erhalten wurde, gesammelt wird, weist auf: mehrere Mikroreaktoren (101a, 101b, 101c), die parallel angeordnet sind, einen Durchflussmesser (104), der auf der stromabwärts liegenden Seite angeordnet ist, einen Detektor (105), der die Zusammensetzung der Mischlösung erfasst, und eine Verarbeitungsvorrichtung (108), die sowohl die Reaktionszeit ab dem Vermischen der Materiallösungen bis zur Erfassung der Zusammensetzung der Mischlösung durch den Detektor (105) als auch die Ausbeute an Zielprodukt berechnet. Die Verarbeitungsvorrichtung (108) umfasst Mittel zur Änderung der Menge jeder der Materiallösungen, die durch ...

Mikrofluidik-Einrichtung

Zur Überwachung der Abnutzung einer Mikrofluidik-Einrichtung mit Fluidkanälen (7) sind diesen Sensoren (9) zur Erfassung durchflussrelevante Größen zugeordnet. Ein Einrichtung (13) speichert die Werte der erfassten Größen und eine Vergleichseinrichtung (14) vergleicht die Werte der erfassten Größen mit bereits abgespeicherten früheren Werten. Eine Auswerteeinrichtung (15) erzeugt eine Meldung, wenn die Abweichung zwischen den miteinander verglichenen Werten ein vorgegebenes Maß übersteigt.

MICRO FLUIDIC SYSTEM

FLUID MIXTURE AND REACTION PROCEDURE WITH USE OF A MICRO DEVICE, AND MICRO DEVICE

RETENTION TIME MODULE FOR MICRO REACTORS

MICROFLUIDIC CHEMICAL REACTOR FOR THE MANUFACTURE OF CHEMICALLY-PRODUCED NANOPARTICLES

The present invention discloses microfluidic modules for making nanocrystalline materials in a continuous flow process. The microfluidic modules include one or more flow path with mixing structures and one or more controlled heat exchangers to process the nanocrystalline materials and reagents in the flow path. The microfluidic modules can be interconnected to form microfluidic reactors that incorporate one or more process functions such as nucleation, growth, and purification.

ADJUSTABLE PRESSURE MICROREACTOR

Technologies are generally described for adjusting a pressure in a microreactor system. An example microreactor system may include a reaction chamber, wherein the reaction chamber is effective to receive at least one reactant, and carry out a reaction on the reactant to produce a product. An example method may comprise controlling a first electroosmotic pump to drive a first fluid toward the reaction chamber with a first force. In some examples. the method may further comprise controlling a second electroosmotic pump to drive a second fluid toward the reaction chamber with a second force. In some examples, the method may further comprise carrying out the reaction on the reactants in the reaction chamber to produce the product. The first and the second forces may be effective to generate a pressure inside the reaction chamber, where the pressure is greater than one atmosphere.

Замкнутая испарительная система

Catalytic plate reactors

Catalytic plate reactors

PROCESS OF CONTROL OF ADVANCED Of a LIQUID IN a COMPOS ANT MICROFLUIDIQUE

Le procédé de contrôle de l'avancée d'un liquide, de l'amont vers l'aval, dans un composant microfluidique comprenant, par exemple, une pluralité de microcanaux, comportant chacun une pluralité de zones de réaction ou de détection successives et une pluralité de vannes passives, contrôle l'avancée du liquide dans les microcanaux par le contrôle de l'augmentation d'une différence de pression entre l'amont et l'aval du composant. Le procédé contrôle l'augmentation de la différence de pression de manière discontinue sous forme d'impulsions de déblocage (Pd), de manière notamment à synchroniser le passage des vannes passives correspondantes des microcanaux.

SYSTEM OF WATER SEPARATION

Système de séparation d'eau (100), il comprend une unité de mélange 3 dans laquelle les ingrédients sont introduits et mélangés, une unité de traitement réactionnel chimique 4 qui est disposé sous l'unité de mélange 3 et dans laquelle les ingrédients mélangés subissent une réaction chimique, une unité de séparation d'eau 6 connectée sous l'unité de traitement réactionnel chimique 4 pour séparer l'eau produite dans l'unité de traitement réactionnel chimique 4, et une unité de contrôle 12 pour contrôler le temps de réaction chimique dans l'unité de traitement réactionnel chimique 4. L'unité de contrôle 12 raccourcit le temps de réaction chimique dans l'unité de traitement réactionnel chimique 4 quand la solution déchargée de l'unité de traitement réactionnel chimique 4 contient une grande quantité de produit, et prolonge le temps de réaction chimique dans l'unité 4 quand la solution déchargée de l'unité 4 contient une petite quantité de produit.

FULLY-AUTOMATED MICROFLUIDIC SYSTEM FOR THE SYNTHESIS OF RADIOLABELED BIOMARKERS FOR POSITRON EMISSION TOMOGRAPHY

The present application relates to microf luidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses, a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and method of using such instruments. The systems comprise a microfluidic synthesis chip comprising a reagent source, a controller, a reaction chamber, a membrane, at least one flow channel and at least one valve (260, 265). The systems may additionally comprise radiation shielding and heating or cooling elements (270).

Patent RU2016112554A3

Improved flow synthesis

A method of synthesising an organic high explosive, comprising the steps of (i) providing a solution A comprising a nitrating agent, (ii) providing a solution B comprising an explosive precursor reagent, wherein the admixture of solution A and solution B are selected such that they are capable upon formation of the admixture of reacting together to provide the organic high explosive, (iii) determining the critical diameter of the organic high explosive, (iv) wherein the flow reactor comprises a pipe, selecting the internal diameter of the pipe such that it is less than the critical diameter of the organic high explosive, thereby preventing detonation of the formed organic high explosive in said flow reactor, (v) causing the solution A and B to be mixed and passed through the flow reactor to create the admixture, to provide the organic high explosive. Preferably, solution A comprising a nitrating agent comprises nitric acid, nitrites. Preferably, the explosive precursor in solution B is ...

MICRO REACTOR WITH IMPROVED HEAT EXCHANGER

MICROREACTOR PROCESS FOR MAKING BIODIESEL

Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the present invention ...

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA OXIDATION IN A MICROREACTOR

Hydrogen peroxide is prepared by an auto-oxidation method via oxidation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a first step and is subsequently oxidized in a microreactor to produce hydrogen peroxide.

APPARATUS AND METHOD FOR MASS PRODUCING A MONODISPERSE MICROBUBBLE AGENT

An apparatus (1) for mass producing monodisperse microbubbles, comprising a microfluidic flow focusing device (2) including a dispersed phase fluid supply channel (110) having an outlet (114) that discharges into a flow focusing junction (140); a continuous phase fluid supply channel (120, 120') having an outlet (124) that discharges into the flow focusing junction; and a bubble formation channel (130) having an inlet (132) disposed at the flow focusing junction. The configuration of the flow focusing junction (140) is such that, in operation, a flow of dispersed phase fluid (12) discharging from the outlet (114) of the dispersed phase fluid supply channel (110) is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.

Efficient dissociation of water vapor in arrays of microchannel plasma devices

The invention provides methods and systems for water dissociation with microplasma generated in microchannel plasma arrays or chips. Preferred methods and systems introduce water vapor into a microchannel plasma array. Electrical power is applied to the microchannel plasma array to create a plasma chemical reaction of the water vapor in the microchannel plasma array. Dissociated hydrogen and/or oxygen gas is collected at an output of the microchannel plasma array. The water vapor can be entrained in a carrier gas, but is preferably introduced without carrier gas. Direct introduction of water vapor has been demonstrated to provide efficiencies at an above 60%. The use of carrier gas reduces efficiency, but still exceeds efficiencies of prior methods discussed in the background.

Device and Methods for Disinfecting Dental Lines

Described is a combination method, including a device and system for disinfecting and decontaminating water lines, for example, dental water lines, in the absence of a primary chemical component.

Chemical apparatus

In a chemical apparatus, for enabling to remove a gas within a pipe, with efficiency, thereby to conduct mixing or reaction or emulsification with stability, a dividing portion (1, 2) is provided for removing the gas within the pipe when supplying an undiluted liquid, from a condition that no liquid is supplied into an undiluted liquid pipe and micro-reactors (31a, 31n), to reduce the gas to be transferred to the micro-reactors, and thereby to remove the gas within the pipe, easily, and further the pipes disposed from the undiluted liquid pump (3, 4) up to the micro-reactors (31a, 31n) are inclined to direct upward, to as to remove the gas in the pipes; whereby achieving stable mixing or reaction or emulsification.

MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS

A microreactor

Closed evaporation system

AUTOXIDATIVE PRODUCTION OF HYDROGEN PEROXIDE OF MEANS OXIDATION IN A MICRO REACTOR

PROCEDURE FOR THE PRODUCTION OF CELEBRATIONS MATERIALS WITHIN THE NANO-SIZE RANGE WITH CONTINUOUS PRECIPITATION

PROCEDURE FOR THE CONTROLLING OF THE PROCESS OF A LIQUID IN A MICRO-FLUID UNIT

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA HYDROGENATION IN A MICROREACTOR

... ²²²Hydrogen peroxide is prepared by an auto-oxidation method via hydrogenation in ²a microreactor. A working solution containing a reactive carrier compound is ²hydrogenated with hydrogen in a microreactor and is subsequently auto-oxidized ²to produce hydrogen peroxide.² ...

Method for controlling the progression of a fluid in a microfluidic component

The method for controlling the progression of a fluid, from upstream to downstream, in a microfluidic component comprising for example a plurality of microchannels each comprising a plurality of successive reaction or detection zones and a plurality of passive valves, controls the progression of the fluid in the microchannels by controlling the increase of a pressure difference between upstream and downstream of the component. The method controls the pressure difference increase discontinuously in the form of enabling pulses so as in particular to synchronize passing of the corresponding passive valves of the microchannels. The pressure difference is advantageously adjusted to a zero value between two successive enabling pulses.

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA OXIDATION IN A MICROREACTOR

Hydrogen peroxide is prepared by an auto-oxidation method via oxidation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a first step and is subsequently oxidized in a microreactor to produce hydrogen peroxide.

METHOD FOR PRODUCTION OF AZO DYES IN MICROREACTORS

The invention relates to a method for the production of azo dyes, characterised in that the diazotisation of aromatic or heteroaromatic amines, or the azo coupling reaction, or the diazotisation and the azo coupling reaction are carried out in a microreactor. © KIPO & WIPO 2007 ...

PRODUCTION BY AUTOOXIDATION OF PEROXIDE OF HYDROGEN THROUGH HYDROGENATION IN A MICROREACTOR

Un método auto-oxidacion para la produccion de peroxido de hidrogeno que comprende: efectuar la hidrogenacion de un compuesto elaborador en un micro reactor que contiene un catalizador de hidrogenacion. Método cíclico para la produccion de peroxido de hidrogeno que comprende hidrogenar un compuesto elaborador en un micro reactor que contiene un catalizador de hidrogenacion, oxidar el compuesto elaborador hidrogenado para producir peroxido de hidrogeno, recuperar el peroxido de hidrogeno y reciclar el compuesto elaborador oxidado.

METHOD FOR CONTROLLING THE PROGRESS OF A LIQUID IN A MICROFLUID COMPONENT

The method for controlling the downstream progress of a liquid in a microfluid component, comprising, for example, a number of microchannels, each having a number of successive reaction or detection zones and a number of passive valves, controls the progress of the liquid in the microchannels by controlling the increase of pressure differential between the upstream and downstream end of the component. The method controls the increase in pressure differential in a discontinuous manner in the form of release pulses (Pd), such as to particularly synchronise the passage through the corresponding passive valves in the microchannels. The pressure difference is reduced to a zero value between two successive release pulses (Pd).

Auto-oxidation production of hydrogen peroxide via hydrogenation in a microreactor

Hydrogen peroxide is prepared by an auto-oxidation method via hydrogenation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a microreactor and is subsequently auto-oxidized to produce hydrogen peroxide.

A CARTRIDGE FOR MIXING A PHOSPHOLIPID COMPOSITION INTENDED FOR INTRACORPOREAL USE

MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Fluid mixing reaction enhancement method using micro device, and micro device

A micro device which makes a plurality of fluids (L1, L2) mixedly react while circulating these fluids (L1, L2) as a thin-film laminar flow by joining these fluids (L1, L2) into one microchannel (14) through respective fluid supply passes (18A, 18B) to induce a velocity fluctuation in a microchannel longitudinal direction of the fluids (L1, L2) by propagating infralow frequency vibration at a vibration frequency of 50 Hz or more and 1 kHz or less to the fluids (L1, L2) which flow through the inside of the microchannel (14).

MICROFLUIDIC SYSTEM

Modulares chemisches Mikroreaktionssystem sowie Verfahren hierfür

DEVICES AND METHODS FOR REDUCING RADIOLYSIS OF RADIOLABELED COMPOUNDS

Disclosed are microfluidic devices and kits for containing radioisotopes. The devices and kits comprises at least one confining geometry having a cross-section dimension below the beta(+) or beta(-) range of a radioisotope, when containing the radioisotope configured in such a way that neighboring segments of the confining geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the segments when containing the radioisotope. Methods of storage and synthesis of radiopharmaceuticals are also disclosed. In another aspect, the present invention relates to methods of storing radiotracers and synthesizing radiopharmaceuticals, using the aforementioned device. The radiotracers and radiopharmaceuticals comprises 18F, 11C, 14C, 99mTc, 123I, 125I,131I, 68Ga, 67Ga, 15O, 13N, 82Rb, 62Cu, 32P, 89Sr, 153Sm, 186Re, 201Tl, 111In, or combinations thereof.

Reactor system for high throughput applications

RECONFIGURABLE CHEMICAL PROCESS SYSTEMS

Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable Lab-on-a-Chip or embedded chemical processor is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory ...

Closed evaporation system

The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.

Fluid mixing reaction enhancement method using micro device, and micro device

A micro device which makes a plurality of fluids mixedly react while circulating these fluids as a thin-film laminar flow by joining these fluids into one microchannel through respective fluid supply passes to induce a velocity fluctuation in a microchannel longitudinal direction of the fluids by propagating infralow frequency vibration at a vibration frequency of 50 Hz or more and 1 kHz or less to the fluids which flow through the inside of the microchannel.

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA HYDROGENATION IN A MICROREACTOR

Hydrogen peroxide is prepared by an auto-oxidation method via hydrogenation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a microreactor and is subsequently auto-oxidized to produce hydrogen peroxide.

MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS

Methods and devices for a fully automated synthesis of radioactive compou nds for imaging, such as by positron emission tomography (PET), in a fast, e fficient and compact manner are disclosed. In particular, the various embodi ments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yi elding purified PET radiotracer within a period of time shorter than convent ional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compoun d, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said rea ction chamber.

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA OXIDATION IN A MICROREACTOR

Hydrogen peroxide is prepared by an auto-oxidation method via oxidation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a first step and is subsequently oxidized in a microreactor to produce hydrogen peroxide.

MICROREACTOR SYSTEM

Auto-oxidation production of hydrogen peroxide via hydrogenation in a microreactor

Hydrogen peroxide is prepared by an auto-oxidation method via hydrogenation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a microreactor and is subsequently auto-oxidized to produce hydrogen peroxide.

VERFAHREN ZUR HERSTELLUNG VON AZOFARBMITTELN IN MIKROREAKTOREN

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA HYDROGENATION IN A MICROREACTOR

Hydrogen peroxide is prepared by an auto-oxidation method via hydrogenation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a microreactor and is subsequently auto-oxidized to produce hydrogen peroxide.

PROCESS OF CONTROL OF ADVANCED Of a LIQUID IN a COMPOS ANT MICROFLUIDIQUE

폐쇄된 증발 시스템

... 본 발명은 방사성 유체를 증발시키기 위한 시스템, 이러한 시스템을 포함하는 방사성표지된 화합물의 합성을 위한 방법, 및 이러한 시스템을 포함하는 방사성표지된 화합물의 합성을 위한 카세트를 제공한다. 본 발명은, 핫 셀에 방출되는 방사성 기체 화학물질의 양을 급격하게 감소시키기 때문에 방사성 유체의 증발을 위한 알려진 방법에 비해 장점을 제공한다. 본 발명은 알려진 공정에 비해 더 온건하고 더 안전하며 증발 동안 휘발성 방사성 기체의 방출에 관련된 안전상의 이유로 허용될 수 없었던 방사성합성 공정에 대한 접근을 제공한다. 또한, 방사성 휘발물은 표지된 중간 종이기 때문에 공정 수율이 더 높다.

APPARATUS AND METHOD FOR MASS PRODUCING A MONODISPERSE MICROBUBBLE AGENT

An apparatus for mass producing monodisperse microbubbles contains a microfluidic flow focusing device. The microfluidic flow focusing device includes a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction, a continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction, and a bubble formation channel having an inlet disposed at the flow focusing junction. The configuration of the flow focusing junction is such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.

Apparatus for blending water with sand

A water blending apparatus for use in conditioning foundry sand. The apparatus creates a vertical sand stream flow path which increases the surface area of the sand stream and allows water to be applied to both sides of the sand stream rather than a single side, as known with conventional water mixing apparatus. In addition, the blending apparatus includes a housing inside which a pair of mixers thoroughly mix the wetted sand. Because the mixers are not positioned in-line with the main sand processing flow, as in conventional apparatus, the mixing time is not dependent upon the speed of the conveyor, and therefore mixing time may be increased. Furthermore, the agitators positioned inside the housing have a more efficient active area since a smaller clearance space is required than with over-the-conveyor style mixing devices, which must avoid contact with the conveyor belt. As a result, the sand may be cooled more quickly due to increased initial water coverage. Furthermore, the sand is ...

FLOW CHANNEL STRUCTURE AND LIPID PARTICLE OR MICELLE FORMATION METHOD USING SAME

Provided are: a flow channel structure with which lipid particles or micelles, which are useful as nano-sized carriers, for example, in drug delivery systems, are produced with good control of particle size; and a method for forming lipid particles or micelles using the same. Said flow channel structure has a two-dimensional structure such as one in which multiple structural elements (baffles) of a specified width are alternately disposed from the two side faces in a micro-sized flow channel through which feedstock solutions are flowed.

DEVICES AND METHODS FOR REDUCING RADIOLYSIS OF RADIOLABELED COMPOUNDS

Disclosed are microfluidic devices and kits for containing radioisotopes. The devices and kits comprises at least one confining geometry having a cross-section dimension below the beta(+) or beta(-) range of a radioisotope, when containing the radioisotope configured in such a way that neighboring segments of the confining geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the segments when containing the radioisotope. Methods of storage and synthesis of radiopharmaceuticals are also disclosed. In another aspect, the present invention relates to methods of storing radiotracers and synthesizing radiopharmaceuticals, using the aforementioned device. The radiotracers and radiopharmaceuticals comprises 18F, 11C, 14C, 99mTc, 123I, 125I,131I, 68Ga, 67Ga, 15O, 13N, 82Rb, 62Cu, 32P, 89Sr, 153Sm, 186Re, 201Tl, 111In, or combinations thereof.

AUTO-OXIDATION PRODUCTION OF HYDROGEN PEROXIDE VIA HYDROGENATION IN A MICROREACTOR

Hydrogen peroxide is prepared by an auto-oxidation method via hydrogenation in a microreactor. A working solution containing a reactive carrier compound is hydrogenated with hydrogen in a microreactor and is subsequently auto-oxidized to produce hydrogen peroxide.

Device with flow sensor for handling fluids

A channel substrate containing at least one channel for a fluid is provided. A sensor substrate carrying a thermal flow sensor is arranged adjacent to the channel substrate. The flow sensor contains at least one temperature sensor and at least one heater, which are integrated on the sensor substrate. The heater and the temperature sensor are in thermal contact with the channel in the channel substrate. This arrangement allows to measure the flow of the fluid in the channel, which provides an improved monitoring and control. The sensor substrate can have contact pads connected to bond wires or, using flip-chip technology, the contact pads can be connected to circuit paths to the channel substrate.

Fluid distribution device, micro plant, method of designing fluid distribution device, and method of detecting blockage of flow channel

The present invention provides a fluid distribution device for uniformly distributing and outputting a fluid, which is supplied to an input flow channel, into at least three output flow channels, comprising a plurality of branch flow channels, at least three fluid bifurcation portions, and at least one fluid converging portion, wherein the fluid distribution device is configured to correspond to a pressure drop compartment connection model composed of a fluid balance equation and a pressure balance equation. Furthermore, the present invention provides a micro plant using the fluid distribution device, a method of designing the fluid distribution device and a method of detecting blockage of flow channels of the fluid distribution device.

Apparatus for providing constant flow conditions of two different fluid phases in micro-channel elements with cellular structures, comprises micro-channel element, first fluid reservoir, and second fluid reservoir arranged in hollow needle

Apparatus for providing constant flow conditions of at least two different fluid phases in micro-channel elements with the cellular structures, comprises: at least one micro-channel element (1) with channels (2); a first fluid reservoir (3) with at least one inlet and outlet opening arranged such that each outlet opening is connected to a respective opening of a channel of a micro-channel element; and a second fluid reservoir (4) arranged in the hollow needle. A second fluid supplied by at least one inlet, is supplied into each channel of a micro-channel element, through the hollow needles. Apparatus for providing constant flow conditions of at least two different fluid phases in micro-channel elements with the cellular structures, comprises: at least one micro-channel element (1) with channels (2), which continuously have a constant cross-sectional area; a first fluid reservoir (3) with at least one inlet and outlet opening that are aligned in one direction and arranged such that each ...

MICROFLUIDIC SYSTEM

The microfluidic system is constituted of modules that comprise one microfluidic unit and one corresponding electric control unit each and that are retained on a rear panel unit next to each other in a row. The aim of the invention is to prevent the formation or accumulation of ignitable or toxic gas mixtures. For this purpose, a fluid conduit (27) for a rinsing fluid (28) extends through the rear panel unit (9). Branches (29) lead from said fluid conduit (27) to the modules (2), said branches (29) flowing into respective distributor compartments (30) that extend vertically across the module height in the modules (2). Said distributor compartments are delimited in relation to the interior (19) of the respective module (2) by a distributor panel (32) that is provided with openings (31). The interior (19) of the respective module (2) comprises, on its lower or rear surface, an exit opening (33) for the rinsing fluid (28).

Droplet-based microreactors for nanoparticles

Different Au—Pd nanoparticles, ranging from sharp-branched octopods to core@shell octahedra, can be achieved by inline manipulation of reagent flowrates in a microreactor for seeded growth. Significantly, these structures represent different kinetic products, demonstrating an inline control strategy toward kinetic nanoparticle products that should be generally applicable.

Method of producing organic pigment fine-particles, and organic pigment fine-particles obtained thereby and liquid dispersion of the same

A method of producing organic pigment fine-particles, comprising: bringing a solution of an organic pigment soluble form dissolved in an organic solvent in a flow reactor; and converting the organic pigment soluble form into an organic pigment in the course of flow of said solution.

Catalytic plate reactors

A method of controlling the temperature of autothermal microchannel reactors is disclosed. A hierarchical control structure employs a distributed temperature controller including a phase change material and a supervisory control system including the control of one or more inputs into the reactor. The phase change material acts as a fast, distributed controller, and the supervisory controller acts over a longer time horizon to mitigate persistent disturbances. A stochastic optimization method for selecting the phase change layer thickness is employed.

For high-throughput application of reactor system

MICROREACTOR PROCESS FOR MAKING BIODIESEL

Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, propanol, butanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the ...

FLOW ADJUSTING DEVICE, MICRO-REACTOR AND USE THEREOF

A micro-reactor having a plurality of introduction flow paths (21, 22) for introducing plural types of fluid, a merging section (23) for the merging of the plurality of introduction flow paths (21, 22), and a reaction flow path (41) arranged downstream from the above merging section (23), characterized in that a flow adjusting section (80) is arranged at a position being downstream from the above merging section (23) and upstream of the above reaction flow path (41), and a movable particle (82) is caused to be present in the flow path (81) of the above flow adjusting section (80). The above micro-reactor is improved in the adjustment of the flowing state within the reaction flow path (41), and thus can achieve a flowing state with good reproducibility.

Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography

The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.

Method of producing organic pigment fine-particles, and organic pigment fine-particles obtained thereby and liquid dispersion of the same

A method of producing organic pigment fine-particles, comprising: bringing a solution of an organic pigment soluble form dissolved in an organic solvent in a flow reactor; and converting the organic pigment soluble form into an organic pigment in the course of flow of said solution.

Mikroreaktor und Verfahren zur Herstellung eines solchen sowie Verfahren zur Herstellung eines Substrats für einen Mikroreaktor

Die vorliegende Erfindung betrifft einen Mikroreaktor, der ein Substrat (10, 20, 80) mit einer Hohlraumstruktur und mindestens ein auf und/oder in der Hohlraumstruktur angeordnetes katalytisch aktives Material aufweist. Die Erfindung zeichnet sich dadurch aus, dass das Substrat (10, 20, 80) eine erste Schicht (11, 21, 80) und ggf. mindestens eine weitere Schicht (12, 22) aus einem keramischen Material aufweist, wobei die erste Schicht (11, 21, 80) mindestens eine erste Komponente aus einem kristallinen Keramikmaterial und/oder einem Glasmaterial als Matrix und eine zweite Komponente aus einem weiteren kristallinen Keramikmaterial enthält. Die Hohlraumstruktur (14, 24, 84) ist dadurch gebildet, dass Mantelbereich der Kristalle und/oder Kristallagglomerate der zweiten Komponente in der ersten Schicht (11, 21, 80) mindestens bereichsweise herausgeätzt sind. Die Erfindung betrifft ferner ein Verfahren zur Herstellung eines derartigen Mikroreaktors sowie ein Verfahren zur Herstellung eines Substrats ...

FLUID REACTOR

This invention provides a fluid reactor which can mix a plurality of fluids using a microspace and can efficiently conduct various chemical reaction work and thus is suitable as practical mass production means. In this fluid reactor, a plurality of fluids (A, B) are introduced into a reaction passage (62) having a microreaction space for reaction. The fluid reactor comprises an introduction part (2) for introducing individual fluids for reaction, a flat plate mixing substrate (40) with mixing passages (56, 57, 58) for allowing the fluids to meet together for mixing, fluid transport means(16A, 16B) for transporting fluids towards the mixing passages through a plurality of transport pipes (21A, 21B), flow rate control means (20) for regulating the flow rate of the fluids, temperature control means (7) for regulating the temperature of a reaction passage (62), a lead-out part (104) for leading out a material after the reaction, and an operation control means (6) for controlling these motions ...

METHOD FOR PRODUCTION OF AZO DYES IN MICROREACTORS

본 발명은 방향족 또는 이종방향족 아민의 디아조화, 아조 커플링 반응, 또는 디아조화 및 아조 커플링 반응을 마이크로반응기에서 수행함을 특징으로 하는, 아조 염료의 제조 방법에 관한 것이다. The present invention relates to a process for the preparation of azo dyes, characterized in that the diazotization, azo coupling reaction, or diazotization and azo coupling reaction of aromatic or heteroaromatic amines is carried out in a microreactor.

REACTION APPARATUS IN WHICH A TOP PLATE IS REINFORCED BY JOINING COMPARTMENT PLATES TO THE TOP PLATE

PURPOSE: A reaction apparatus is provided to reduce the thickness of a metal plate forming a reaction vessel while maintaining strength of the reaction vessel. CONSTITUTION: A reaction apparatus has a reaction vessel which is provided with reactants and causes a reaction of the reactants. The reaction vessel includes: a hollow box type member having a first plate on which channels are formed to supply the reactants, a second plate opposite to the first plate, and third plates which are consecutively installed at the edges of the first plate and the edges of the second plate; and one or many compartment plates which partition a space within the box type member, are disposed to form a reaction channel in which the reactants flow, and are joined to the inner surface of the second plate. © KIPO 2007 ...

MICROFLUIDIC CHEMICAL REACTOR FOR THE MANUFACTURE OF CHEMICALLY-PRODUCED NANOPARTICLES

The present invention discloses microfluidic modules for making nanocrystalline materials in a continuous flow process. The microfluidic modules include one or more flow path with mixing structures and one or more controlled heat exchangers to process the nanocrystalline materials and reagents in the flow path. The microfluidic modules can be interconnected to form microfluidic reactors that incorporate one or more process functions such as nucleation, growth, and purification.

REACTION ANALYSIS DEVICE, REACTION ANALYSIS SYSTEM, AND REACTION ANALYSIS METHOD

A reaction analysis device specifies a reaction state of a reaction fluid flowing through a flow reactor. The reaction analysis device includes a processor configured to specify the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid which is obtained from a temperature distribution of the reaction fluid immediately after a reaction starts in a flow direction of the reaction fluid.

Microchannel cleaning method

모듈식 연속 흐름 장치

... 본 발명은 연속 흐름 조건 하에서의 자동화된 화학적 다단계 합성을 위한 모듈식 연속 흐름 장치에 관련된다. 이 장치는 복수의 서로 다른 유형의 연속 흐름 모듈 및 이 연속 흐름 모듈을 서로에 병렬식으로 또는 방사식으로 접속시키기 위한 밸브 조립체를 포함한다. 이러한 구성은 최종 생성물을 획득하기 위한 주요 합성 반응 시퀀스에서 필요한 적어도 하나의 중간 생성물을 사전 합성하고 중간에 저장하거나 동시에 합성함으로써 화학적 반응 시퀀스를 수행하는 것을 가능하게 한다.

A PROCESS FOR THE PREPARATION OF UNIFORM NANO-SIZED SOLID MATERIALS BY CONTINUOUS PRECIPITATION

Fixed bed mixed gas/liquid phase reactor and mixed gas/liquid phase reaction process using the same

The present invention provides a fixed bed reactor for carrying out a mixed gas/liquid phase reaction, wherein the reactor has a piping structure composed of microchannels, the cross-sectional area of the fixed bed is 0.0001 cm 2 to 0.008 cm 2 and a single or parallely arranged two or more fixed beds, and the reactor has, in addition to the fixed beds, a gas phase distribution portion, a portion for introducing the gas phase to the fixed bed, a liquid phase distribution portion, a portion for introducing the liquid phase to the fixed bed, a packing material introduction portion and a fluid merging portion, a gas/liquid mixed phase reaction process for carrying out a gas/liquid mixed phase reaction using the fixed bed reactor described above, and further a process for producing hydrogen peroxide in which the reaction is started and stopped in a reducing atmosphere, and the present invention further provides a novel fixed bed gas/liquid mixed phase reactor which makes it possible to carry out gas/liquid mixed phase reactions stably and under steady state conditions by using microchannels.

TRIPHASIC FLOW MILLIREACTORS

Disclosed is a reactor system that contains multiple millireactors, each including a millitube, a first feed line, a second feed line, and a third feed line. Each of the first and second feed lines has a hydraulic damper disposed therein. Also disclosed is a process for conducting in a millitube a triphasic flow reaction that requires a liquid reactant, a gas reactant, and a catalyst.

Flow synthesis of polymer nanoparticles

A system and method for flow synthesis of polymer nanoparticles in a continuous flow reactor having a channel. The polymer nanoparticles are synthesized from monomer in the presence of an initiator.

FIXED BED MIXED GAS/LIQUID PHASE REACTOR AND MIXED GAS/LIQUID PHASE REACTION PROCESS USING THE SAME

CATALYTIC PLATE REACTORS

A method of controlling the temperature of autothermal microchannel reactors is disclosed. A hierarchical control structure employs a distributed temperature controller including a phase change material and a supervisory control system including the control of one or more inputs into the reactor. The phase change material acts as a fast, distributed controller, and the supervisory controller acts over a longer time horizon to mitigate persistent disturbances. A stochastic optimization method for selecting the phase change layer thickness is employed.

Microreactor and method for producing same and method for producing a substrate for a microreactor

Die vorliegende Erfindung betrifft einen Mikroreaktor, der ein Substrat (10, 20, 80) mit einer Hohlraumstruktur und mindestens ein auf und/oder in der Hohlraumstruktur angeordnetes katalytisch aktives Material aufweist. Die Erfindung zeichnet sich dadurch aus, dass das Substrat (10, 20, 80) eine erste Schicht (11, 21, 80) und ggf. mindestens eine weitere Schicht (12, 22) aus einem keramischen Material aufweist, wobei die erste Schicht (11, 21, 80) aus mindestens einer ersten Komponente aus einem kristallinen Keramikmaterial und/oder einem Glasmaterial als Matrix und einer zweiten Komponente aus einem weiteren kristallinen Keramikmaterial enthält. Die Hohlraumstruktur (14, 24, 84) ist dadurch gebildet, dass Mantelbereiche der Kristalle und/oder Kristallagglomerate der zweiten Komponente in der ersten Schicht (11, 21, 80) mindestens bereichsweise herausgeätzt sind. Die Erfindung betrifft ferner ein Verfahren zur Herstellung eines derartigen Mikroreaktors sowie ein Verfahren zu Herstellung ...

CLEANING METHOD OF MICRO-PASSAGE

PROBLEM TO BE SOLVED: To provide a cleaning method having an excellent cleanability of a micro-passage and cleaning a device having the micro-passage without disassembling the device. SOLUTION: The cleaning method of the micro-passage is characterized by including steps of: generating air bubble by electrolyzing the fluid flowing in the micro-passage; and making the fluid containing the air bubble pass through the micro-passage. The cleaning method of the micro-passage is preferably the method for performing the electrolysis by electrodes provided opposing to the micro-passage. COPYRIGHT: (C)2008,JPO&INPIT ...

Flluidtransport in mikrofluidischen Anwendungen

Ein Verfahren enthält ein Zuführen einer Flüssigkeit in einen Kanal einer Mikrofluidkassette, die mit einem Gas gefüllt ist. Der Kanal weist einen Einlassabschnitt und einen Auslassabschnitt auf. Das Verfahren beinhaltet ferner ein Detektieren der Flüssigkeit, des Gases oder einer Kombination davon an einem Messort in dem Einlassabschnitt. Der Messort weist einen ersten Sensor auf, der ein Signal detektieren kann, das eine Anwesenheit der Flüssigkeit, des Gases oder einer Kombination davon kennzeichnet. Das Verfahren beinhaltet ferner ein Verdichten des Gases, ein Bestimmen einer Druckänderung des Gases in dem Kanal und ein Bestimmen eines Volumens der Flüssigkeit in dem Kanal auf Basis der Druckänderung des Gases.

Fluidisches Misch- und Reaktionsverfahren mit Verwendung einer Mikrovorrichtung, und Mikrovorrichtung

REACTOR

MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS

MODULAR CONTINUOUS FLOW DEVICE

Methods and apparatus for producing biochips

The methods and apparatus of the present invention for fabricating biochips permit the quick and easy mass-production of biological polymer chips with uniform quality and the depositing of very small amounts of biological polymer. According to the present invention, samples of a biological polymer are deposited on a substrate by means of a capillary array comprising a plurality of capillaries arranged at the same spacing interval as that of sites on the substrate. At this point, it is possible to deposit the biological polymer samples on a plurality of sites on the substrate, all at one time, by applying electric fields or pneumatic pressure to the array of capillaries containing the biological polymer samples. This method offers the advantages that biochips are produced quickly, deposited samples are volumetrically identical, and very small amounts of biological polymer can also be pipetted.

Mikroreaktor für Reaktionen zwischen Gasen und Flüssigkeiten

The invention relates to a micro-reactor for carrying out chemical reactions between a liquid reaction partner and a gaseous reaction partner, optionally in the presence of a solid catalyst. The chemical process takes place in chambers which are formed by two or more plates or layers that run substantially plane-parallel. At least one of said plates or layers constitutes a fluid conducting plate that is textured and/or positioned in such a way, that the liquid reaction partner flows in a substantially continuous capillary thread along the surface of said plate or layer only as a result of the influence of gravity and/or of capillary forces, whereby it comes into contact and reacts with the gaseous reaction partner.

Verfahren und Vorrichtung zum Testen eines mikrofluidischen Systems

Die Erfindung betrifft ein Verfahren zum Testen eines mikrofluidischen Systems (102), wobei das System (102) zumindest einen Kanal (104) zwischen einem Einlass (110) des Systems (102) und einem Auslass (112) des Systems (102) sowie zumindest ein in dem Kanal (104) angeordnetes Ventil (120) aufweist. Das Verfahren weist einen Schritt des Anlegens, einen Schritt des Betätigens und einen Schritt des Erfassens auf. Im Schritt (502) des Anlegens wird eine Druckdifferenz zwischen dem Einlass (110) und dem Auslass (112) angelegt. Im Schritt des Betätigens wird das Ventil (120) betätigt. Im Schritt des Erfassens wird eine fluidische Rückkopplung des Systems (102) erfasst, um einen fluidischen Pfad zwischen dem Einlass (110) und dem Auslass (112) auf eine Funktionsfähigkeit zu überprüfen.

MICROFLUIDIC DEVICE

In order to monitor the wear and tear of a microfluidic device with fluid channels (7), sensors (9) for detecting flow-relevant quantities are assigned to said fluid channels. A device (13) stores the values of the detected quantities and a comparison device (14) compares the values of the detected quantities with already stored former values. An evaluation device (15) generate a message when the difference between the values that are compared to one another exceed a predetermined measure.

Device with flow sensor for handling fluids

A channel substrate containing at least one channel for a fluid is provided. A sensor substrate carrying a thermal flow sensor is arranged adjacent to the channel substrate. The flow sensor contains at least one temperature sensor and at least one heater, which are integrated on the sensor substrate. The heater and the temperature sensor are in thermal contact with the channel in the channel substrate. This arrangement allows to measure the flow of the fluid in the channel, which provides an improved monitoring and control. The sensor substrate can have contact pads connected to bond wires or, using flip-chip technology, the contact pads can be connected to circuit paths to the channel substrate.

Microreactor

A method of optimising a reaction in a microreactor. Two reaction fluids A, B as supplied to a microchannel 6 and their relative proportions are varied in a controlled manner. A sensor 13 monitors a reaction characteristic and determines the relative proportion of the fluids which optimises the yield of the reaction product. The total flow rate can also be varied at the optimum relative proportion in order to determine the maximum overall flow rate at which completion of the reactions still occurs.

Reactor system for high throughput applications

A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel.

APPARATUS FOR MASS PRODUCING A MONODISPERSE MICROBUBBLE AGENT

An apparatus for mass producing monodisperse microbubbles includes a microfluidic flow focusing device, which includes a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction, a continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction, and a bubble formation channel having an inlet disposed at the flow focusing junction. The configuration of the flow focusing junction is such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel. 1. An apparatus for mass producing monodisperse microbubbles , comprising: a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction;', 'at least one continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction; and', 'a bubble formation channel having an inlet disposed at the flow focusing junction,, 'at least one microfluidic flow focusing device including 'wherein said bubble formation channel has a length that is much greater than its hydraulic diameter by a factor of at least ten.', 'the configuration of the flow focusing junction being such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel,'}2. The apparatus according to claim 1 , further comprising:a source ...

System and method for rehydrating powder and delivering the rehydrated powderto a reactor

A closed system for rehydrating powder and delivering the rehydrated powder to a reactor, may include a liquid reservoir for containing liquid; a syringe configured to contain powder to be rehydrated; a reactor; a controller for controlling operation of the syringe; and a conduit fluidically linking the liquid reservoir to a port of the syringe, fluidically linking the port to the reactor. The controller is configured to operate the syringe so as to draw liquid from the liquid reservoir into the syringe and rehydrate the powder, or to drive the rehydrated powder into the reactor.

REACTOR SYSTEM FOR HIGH THROUGHPUT APPLICATIONS

A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel. 120.-. (canceled)21. A reactor system for high throughput applications , which reactor system comprises: a flow-through reactor, said flow-through reactor comprising a reactor inlet and a reactor outlet, which flow-through reactor is adapted to accommodate a chemical reaction,', 'a reactor feed line, which reactor feed line has a first end and a second end, said second end being connected to the reactor inlet of the flow-through reactor, said reactor feed line being adapted to supply a fluid to the flow-through reactor, and', 'a reactor effluent line, which reactor effluent line has a first end, which first end is connected to the reactor outlet of the flow-through reactor, said reactor effluent line being adapted to discharge reactor effluent from the flow-through reactor,, 'a plurality of reactor assemblies, each reactor assembly comprisinga fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, anda flow path controller which is adapted to transfer said pressurized fluid from the fluid source to the reactor assemblies, so that said ...

CLOSED EVAPORATION SYSTEM

The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species. 121-. (canceled)22. A method for the synthesis of a radiolabelled compound wherein said method comprises:(i) radiolabelling a protected precursor compound in a fixed volume container to obtain a protected radiolabelled compound;(ii) deprotecting the protected radiolabelled compound obtained from radiolabelling step (i) to obtain said radiolabelled compound wherein said deprotection is effected using a hydrolysis medium;(iii) connecting the fixed volume container via a 3-way valve to an expandable volume; and,(iv) heating the radioactive fluid in the fixed volume container above its boiling point to reach the equilibrium gas/liquid phase causing said liquid to vaporise and move into the expandable volume where it condenses due to the drop in temperature to form a volume of radioactive fluid in the expandable volume.23. The method as defined in wherein said fixed volume container is a reaction vessel.24. The system as defined in wherein said expandable volume is a syringe.25. The method as defined in wherein said radiolabelled compound is a radiopharmaceutical.26. The method as defined in wherein said radiopharmaceutical is a diagnostic radiopharmaceutical.27. The method as defined in wherein said ...

Valve configurations facilitating clearing, cleaning, drying, and burst formation for microfluidic devices, fluidic arrangements, and other systems

A software-controlled triangle-topology valve-cluster for use at taps or conduit junction points that facilitate fluid-based clearing, gas-based clearing, solvent-based cleaning, gas drying, small-volume burst formation, abandoned-material return, and other valuable operations is disclosed. The invention provides better contamination performance than simple passive or valve-chaperoned “T”-topology junctions. The valve-cluster arrangement can be implemented or approximated in various ways. For faster performance, simplified programming, or other reasons “macro” controllability can be provided for operating groups of valves in one or more of simultaneous operation, time-defined sequenced operation, or conditional operation, and such macros can further provide for conditional inputs or parameters. Such “macro,” “conditional-macro,” and “parameterized-macro” control could be implemented in software, firmware, and/or hard-wired logic. The invention can be used in reusable or reconfigurable microfluidic systems, facilitate decontaminated and green disposal and recycling of microfluidics, and other fluidic applications. Features of the invention can also be extended to gas transport.

Microfluidic system based on active control of flow resistance in microfluidic channels and methods of use thereof

The invention relates to a microfluidic system based on active control of flow resistance and balancing pressures in microfluidic channels and an improved method for disposable microfluidic devices and cartridges for use in, but not limited to, in-vitro diagnostics. The microfluidic system and device of the invention does not utilize mechanical moving parts to control the fluid flow and has no external fluidic connection to the instrument or fluidics controller.

MICROREACTOR, CHEMICAL PRODUCT MANUFACTURING SYSTEM AND MICROREACTOR MANUFACTURING METHOD

In mixing of raw materials having different flow rate ratios (volume ratios) (different flow rates), in order to achieve a good mixing effect, the present invention includes: for raw materials having different flow rates, a high-flow-rate side flow path () through which a raw material on a high-flow-rate side flows; a low-flow-rate side flow path () through which a raw material on a low-flow-rate side flows; branch flow paths () which are branched from the high-flow-rate side flow path; and a residence flow path () which is a flow path after the branch flow paths () and the low-flow-rate side flow path () merge. The branch flow path () and the branch flow path () merge in a way of sandwiching the low-flow-rate side flow path (). 1. A microreactor , comprising:a plurality of flow paths for a plurality of raw materials with different flow rates to flow therethrough respectively,wherein the flow paths are branched and merge such that a flow path for a high-flow-rate raw material is branched into a plurality of paths and then merges to a flow path for a low-flow-rate raw material.2. The microreactor according to claim 1 , whereinfor internal volumes of flow paths when each of the raw materials finally merge, an internal volume of the flow path for the high-flow-rate raw material is larger than an internal volume of the flow path for the low-flow-rate raw material.3. The microreactor according to claim 1 , whereinthe high-flow-rate raw material, which is branched into a plurality of parts, merges simultaneously with the low-flow-rate raw material.4. The microreactor according to claim 3 , whereinthe high-flow-rate raw material merges from both sides of the low-flow-rate raw material when the high-flow-rate raw material merges with the low-flow-rate raw material.5. The microreactor according to claim 1 , whereina rear part of a merging point of the flow path for the high-flow-rate raw material and the flow path for the low-flow-rate raw material includes at least one ...

SYSTEM AND METHOD FOR SLURRY PREPARATION

A system includes a gasifier configured to gasify a fuel contained within a fuel slurry in order to generate syngas and a black water. The fuel slurry includes at least the fuel and water. The system also includes a black water treatment system fluidly coupled to the gasifier. The black water treatment system is configured to treat the black water to generate a grey water. The black water treatment system includes a first flash tank configured to process the black water by reducing a pressure of the black water to generate a first discharged black water. The black water treatment system also includes a first flow path fluidly coupling a first discharged black water outlet of the first flash tank with a feedstock preparation system configured to generate the fuel slurry in order to provide at least a first portion of the first discharged black water of the first flash tank to the feedstock preparation system. 1. A system , comprising:a gasifier configured to gasify a fuel contained within a fuel slurry comprising at least the fuel and water in order to generate syngas and a black water; a first flash tank configured to process the black water by reducing a pressure of the black water to generate a first discharged black water; and', 'a first flow path fluidly coupling a first discharged black water outlet of the first flash tank with a feedstock preparation system configured to generate the fuel slurry in order to provide at least a first portion of the first discharged black water of the first flash tank to the feedstock preparation system., 'a black water treatment system fluidly coupled to the gasifier, wherein the black water treatment system is configured to treat the black water to generate a grey water, and wherein the black water treatment system comprises2. The system of claim 1 , wherein the feedstock preparation system comprises a fuel slurry preparation tank fluidly coupled to an outlet of the first flow path and configured to receive the first portion of ...

GENERAL-PURPOSE RECONFIGURABLE CONDUIT AND REACTION CHAMBER MICROFLUIDIC ARRANGEMENTS FOR LAB-ON-CHIP AND MINIATURE CHEMICAL PROCESSING

A general-purpose software-reconfigurable chemical process system useful in a wide range of applications is disclosed. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or small-scale chemical manufacturing. 1. A software controllable and software reconfigurable multipurpose embedded microfluidic chemical processor system , the system comprising:a plurality of controllable valves for controlling flows of chemical substances, wherein each of the plurality of controllable valves comprises a plurality of flow ports and a plurality of valve control connections, wherein at least one flow port of the plurality of flow ports of each controllable valve of the plurality of controllable valves is connected to at least one microfluidic conduit selected from a first plurality of microfluidic conduits and at least one microfluidic conduit selected from a second plurality of microfluidic conduits; a plurality of chemical interface ports for transporting the chemical substances, wherein each of the plurality of chemical interface ports is connected to an ...

MICROREACTOR SYSTEM

A microreactor system that can mix fluids at precise timing has two inlets into which fluids are introduced and merges, in a channel, a first fluid introduced from a first inlet and a second fluid introduced from a second inlet, a first pump that sends the first fluid toward the inlets, and a second pump that sends the second fluid toward the inlets, a first fluid detector that detects an arrival of the first fluid at the first inlet, and a second fluid detector that detects an arrival of the second fluid at the second inlet. 1. A microreactor system comprising:a microreactor that has two inlets into which fluids are introduced and a channel merging the fluids, and mixes, in the channel, a first fluid introduced from a first inlet of the inlets and a second fluid introduced from a second inlet of the inlets;a first pump that sends the first fluid toward the inlets;a second pump that sends the second fluid toward the inlets;a first fluid detector that detects an arrival of the first fluid at the first inlet; anda second fluid detector that detects an arrival of the second fluid at the second inlet,wherein the first pump, after starting a transfer of the first fluid toward the first inlet, stops the transfer by detection by the first fluid detector,the second pump, after starting a transfer of the second fluid toward the second inlet, stops the transfer by detection by the second fluid detector,each of the first pump and the second pump resumes the transfer after the transfer of the first fluid is stopped and after the transfer of the second fluid is stopped, andthe first fluid of which transfer has been temporarily stopped and the second fluid of which transfer has been temporarily stopped are introduced into the microreactor and mixed.2. A microreactor system comprising:a microreactor that has two inlets into which fluids are introduced and a channel merging the fluids, and mixes, in the channel, a first fluid introduced from a first inlet of the inlets and a second ...

Flow Synthesis of Polymer Nanoparticles

A system and method for flow synthesis of polymer nanoparticles in a continuous flow reactor having a channel. The polymer nanoparticles are synthesized from monomer in the presence of an initiator.

Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles

The present invention discloses microfluidic modules for making nanocrystalline materials in a continuous flow process. The microfluidic modules include one or more flow path with mixing structures and one or more controlled heat exchangers to process the nanocrystalline materials and reagents in the flow path. The microfluidic modules can be interconnected to form microfluidic reactors that incorporate one or more process functions such as nucleation, growth, and purification.

Method for producing agglomerated resin particles

Apparatus and method for heating microfluidic volumes and moving fluids

A device and method for the temperature control, concentration, volume measurement and transport of microfluidic volumes are provided. The device includes one or more heating elements having a resistive material that varies with temperature. The heating elements are formed into a laminar body that may be formed into a variety of geometries and/or easily married to a second body including micro-well plates, micro-centrifuge tubes and microfluidic circuits.

Auto-oxidation production of hydrogen peroxide via hydrogenation in a microreactor

在微反应器中经加氢通过自动氧化方法制备过氧化氢。在微反应器中用氢对包含反应性载体化合物的工作溶液加氢，随后自动氧化形成过氧化氢。

Microreactor process for making biodiesel

Microreactor Process for Making Biodiesel

Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the present invention can include blending biodiesel produced by the method with petroleum-based products.

Systems and methods for producing a chemical product

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

Method for manufacturing aggregated resin particles

본 발명은, 조대 입자의 혼입이 적고, 입도 분포가 좁은 수지 입자를 연속적이고 고효율로 얻을 수 있는 응집 수지 입자의 제조 방법을 제공하는 것을 과제로 한다. 상기 과제를 해결하기 위해서, 제1 유로, 제2 유로, 및, 제1 유로와 제2 유로가 합류한 합류 유로를 적어도 갖는 마이크로 리액터를 준비하는 공정, 및, 적어도 수지 입자가 분산한 제1 유체를 제1 유로로 도입하고, 응집제 및/또는 응집 촉진제를 함유하는 제2 유체를 제2 유로로 도입하고, 상기 제1 유체의 단위 시간당의 송액량에 대한 상기 제2 유체의 단위 시간당의 송액량이 커지도록 송액하여 상기 합류 유로에서 상기 제1 유체와 상기 제2 유체가 합류한 층류를 발생시켜, 상기 수지 입자를 응집시키는 공정을 포함하는 것을 특징으로 하는 응집 수지 입자의 제조 방법을 제공한다. 마이크로 리액터, 응집 수지 입자의 제조 방법

Fluid reaction device

マイクロ空間を使用して複数の流体を混合させ、種々の化学反応作業を効率良く行うことができる、実用的な量産手段として好適な流体反応装置を提供する。この流体反応装置は、複数の流体Ａ，Ｂをマイクロ反応空間を有する反応流路６２に導入して反応させる流体反応装置にある。この装置は、反応に使用する流体を個々に導入する導入部２と、流体を合流させて混合する混合流路５６，５７，５８を有する平板状の混合基板４０と、流体を複数の輸送管２１Ａ，２１Ｂを介して前記混合流路に向けて輸送する流体輸送手段１６Ａ，１６Ｂと、流体の流量を制御する流量制御手段２０と、反応流路６２の温度を制御する温度制御手段７と、反応後の物質を導出する導出部１０４と、これらの動作を制御する動作制御手段６とを有する。 Provided is a fluid reaction apparatus suitable as a practical mass production means capable of mixing a plurality of fluids using a micro space and performing various chemical reaction operations efficiently. This fluid reaction apparatus is a fluid reaction apparatus in which a plurality of fluids A and B are introduced into a reaction flow path 62 having a micro reaction space and reacted. This apparatus includes an introduction section 2 for individually introducing fluids used for reaction, a flat mixed substrate 40 having mixing channels 56, 57, and 58 for mixing and mixing fluids, and a plurality of transport pipes for fluids. Fluid transporting means 16A, 16B transporting toward the mixing flow path via 21A, 21B, flow rate control means 20 for controlling the flow rate of the fluid, temperature control means 7 for controlling the temperature of the reaction flow path 62, It has the derivation | leading-out part 104 which derives | leads-out the substance after reaction, and the operation control means 6 which controls these operation | movement.

Method for prodn. of azo dyes in microreactors

本发明涉及生产偶氮着色剂的方法，其特征在于芳族或杂芳族胺的重氮化，或偶氮偶合反应，或重氮化和偶氮偶合反应在微型反应器中进行。

Devices for microreactor fluid distribution

Flow adjusting device, micro-reactor and use thereof

A microreactor containing a plurality of introduction channels 21 and 22 for introducing a plurality of liquids, a merging section 23 for merging the plurality of introduction channels 21 and 22, and a reaction channel 41 located on a downstream side of the merging section 23, characterized in that a flow control section 80 is located on a downstream side of the merging section 23 and an upstream side of the reaction channel 41, and the flow control section 80 contains in a channel 81 thereof a movable particle 82. According to the constitution, such a microreactor can be provided that the flow state in the reaction channel 41 is controlled to realize a flow state with good reproducibility.

Microreactor with improved heat exchanger

Method for controlling the progress of a liquid in a microfluid component

控制微流体组件中的液体向下游前进的方法，该组件包括，例如多个微通道，每个微通道具有若干相继的反应或检测区域和若干被动阀，通过控制组件的上游和下游之间的压差控制微通道中的液体的前进。所述方法以释放脉冲(Pd)的形式非连续地控制压差，例如，特别是在微通道中同步导通相应的被动阀。压差在两个相继的释放脉冲(Pd)之间减小到零值。

Apparatus and method for heating microfluidic volumes and moving fluids

A device and method for the temperature control, concentration, volume measurement and transport of microfluidic volumes are provided. The device includes one or more heating elements having a resistive material that varies with temperature. The heating elements are formed into a laminar body that may be formed into a variety of geometries and/or easily married to a second body including micro-well plates, micro-centrifuge tubes and microfluidic circuits.

Reaction analysis device, reaction analysis system, and reaction analysis method

A reaction analysis device specifies a reaction state of a reaction fluid flowing through a flow reactor. The reaction analysis device includes a processor configured to specify the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid which is obtained from a temperature distribution of the reaction fluid immediately after a reaction starts in a flow direction of the reaction fluid.

Adjustable pressure microreactor

总体上描述了用于调节微反应器系统中压力的技术。示例微反应器系统可以包括反应室，其中反应室接收至少一个反应物，并且对该反应物执行反应以产生产物。示例方法可以包括控制第一电渗泵利用第一力朝着反应室推动第一流体。在一些示例中，该方法还可以包括控制第二电渗泵利用第二力朝着反应室推动第二流体。在一些示例中，该方法还包括对反应室中的反应物执行反应以产生产物。第一和第二力在反应室内产生压力，该压力大于一个大气压。

Reactor

Adjustable pressure microreactor

Microreactor system

本发明的微型反应器系统(1)有微型反应器(10)、第1泵(112)、第2泵(122)、检测第1流体向一方的流入口的到达的第1流体检测器(113)、以及检测第2流体向另一方的流入口的到达的第2流体检测器(123)；第1泵(112)在向一方的流入口开始第1流体的移送后，根据第1流体检测器(113)的检测，停止移送；第2泵(122)在向另一方的流入口开始第2流体的移送后，根据第2流体检测器(123)的检测，停止移送；第1泵(112)及第2泵(122)分别在第1流体的移送被停止后、且第2流体的移送被停止后，再开始移送，移送被暂时停止的第1流体和移送被暂时停止的第2流体被向微型反应器(10)导入并混合。

Triphasic flow millireactors

Disclosed is a reactor system that contains multiple millireactors, each including a millitube, a first feed line, a second feed line, and a third feed line. Each of the first and second feed lines has a hydraulic damper disposed therein. Also disclosed is a process for conducting in a millitube a triphasic flow reaction that requires a liquid reactant, a gas reactant, and a catalyst.

A cartridge for mixing a phospholipid composition intended for intracorporeal use

The present invention is related to a cartridge. More in particular, the present invention relates to a cartridge by which a phospholipid composition, held in the cartridge can be mixed, within the cartridge, with a further liquid held in the cartridge or with a pressurized gas. The present invention further relates to a cartridge system comprising such a cartridge and a device in which the cartridge can be releasably inserted, wherein the device is configured for providing pressurized gas(ses) to be used as propellant(s) for moving the liquid(s) inside the cartridge for the purpose of mixing the liquid(s), and/or to be used as gas to be mixed.

A process for the preparation of uniform nano-sized solid materials by continuous precipitation

A process for the preparation of nano-sized solid materials with a uniform particle size and a uniform pore size distribution which comprises the continuous precipitation at atmospheric pressure under constant temperature, constant pH and preselected residence time, in a stirred reaction chamber simultaneously fed with at least two solutions, characterised in that the reaction chamber is a microreactor and in that the pH of the reaction mixture is controlled by the flow of the feeding solutions. Furthermore, hydrotalcites, dawsonites and aluminas with specific morphology, size distribution and pore size which can be prepared by said process.

Flow channel structure and lipid particle or micelle formation method using same

Provided are: a flow channel structure with which lipid particles or micelles, which are useful as nano-sized carriers, for example, in drug delivery systems, are produced with good control of particle size; and a method for forming lipid particles or micelles using the same. Said flow channel structure has a two-dimensional structure such as one in which multiple structural elements (baffles) of a specified width are alternately disposed from the two side faces in a micro-sized flow channel through which feedstock solutions are flowed.

Fluid distribution device, micro plant, method of designing fluid distribution device, and method of detecting clogging of flow passage

Provided is a fluid distribution device for uniformly distributing a fluid supplied into an input flow passage into three or more output flow passages and outputting the fluid. The fluid distribution device is characterized in that the device is constituted by combining a plurality of branch flow passages, and equipped with at least three fluid diverging parts and at least one fluid converging part, and the device is so formed as to correspond to pressure loss compartments-connected models of fluid balance type and pressure balance type. Furthermore, provided are a micro plant using the fluid distribution device, a method of designing the fluid distribution device, and a method of detecting the clogging of the flow passage of the fluid distribution device.

Method for controlling the progress of a liquid in a microfluid component

The method for controlling the downstream progress of a liquid in a microfluid component, comprising, for example, a number of microchannels, each having a number of successive reaction or detection zones and a number of passive valves, controls the progress of the liquid in the microchannels by controlling the increase of pressure differential between the upstream and downstream end of the component. The method controls the increase in pressure differential in a discontinuous manner in the form of release pulses (Pd), such as to particularly synchronise the passage through the corresponding passive valves in the microchannels. The pressure difference is reduced to a zero value between two successive release pulses (Pd).

Reaction apparatus

반응물을 공급하는 유로가 형성되는 제 1 판과, 해당 제 1 판에 대향하는 제 2 판과, 제 1 판의 가장자리와 제 2 판의 가장자리에 연결되어 설치되는 제 3 판을 갖는 중공의 상자형부재와, 상자형부재내의 공간을 간막이하고, 반응물이 흐르는 반응유로를 형성하도록 배치되며, 제 2 판에 대해 실질적으로 수직방향으로 설치되는 격벽부와, 격벽부에 대해 실질적으로 직각으로 단부에 설치된 접합부를 갖고, 접합부가 제 2 판의 내면측에 접합되어 있는 적어도 1개의 간막이판에 의해서 형성되고, 반응물이 공급되고 해당 반응물의 반응을 일으키는 반응용기를 구비하는 반응장치를 제공한다. 간막이판, 일산화탄소제거기, 단열패키지, 기화기, 격벽부

For the reactor assembly of high throughput applications

本发明涉及一种用于高通量应用的反应器系统，该反应器系统包括：多个反应器组件，每个反应器组件包括：流体源，该流体源适于将加压流体提供到流通式反应器；其中在至少一个反应器组件的反应器供给线和/或反应器流出线中存在限流通道，该限流通道被布置在平面形微流体芯片中，该微流体芯片进一步包括与所述限流通道流体联通的芯片入口通道和芯片出口通道，所述芯片入口通道与所述芯片出口通道两者具有长度和直径，其中所述芯片入口通道的直径与所述芯片入口通道的长度相比相等或更小，并且其中所述芯片出口通道的直径与所述芯片出口通道的长度相比相等或更小。

Closed evaporation system

FIELD: nuclear physics and equipment.SUBSTANCE: group of inventions relates to a system for evaporating a radioactive fluid. System for evaporating a radioactive fluid, where the system includes a fixed volume hot zone which comprises a fixed volume container and a heating means; an expandable volume; a three-way valve which in a first position fluidly connects said fixed volume container and said expandable volume and which in a second position fluidly connects said expandable volume and a waste container. Also provided is a method for the synthesis of a radiolabeled compound and a cartridge for the synthesis of a radiopharmaceutical drug.EFFECT: group of inventions allows to achieve higher yields since radioactive volatile substances are labeled intermediate compounds.15 cl, 6 dwg, 1 ex

Reactor and reactor system with the same

Closed evaporation system

본 발명은 방사성 유체를 증발시키기 위한 시스템, 이러한 시스템을 포함하는 방사성표지된 화합물의 합성을 위한 방법, 및 이러한 시스템을 포함하는 방사성표지된 화합물의 합성을 위한 카세트를 제공한다. 본 발명은, 핫 셀에 방출되는 방사성 기체 화학물질의 양을 급격하게 감소시키기 때문에 방사성 유체의 증발을 위한 알려진 방법에 비해 장점을 제공한다. 본 발명은 알려진 공정에 비해 더 온건하고 더 안전하며 증발 동안 휘발성 방사성 기체의 방출에 관련된 안전상의 이유로 허용될 수 없었던 방사성합성 공정에 대한 접근을 제공한다. 또한, 방사성 휘발물은 표지된 중간 종이기 때문에 공정 수율이 더 높다. The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabeled compound comprising such a system, and a cassette for the synthesis of a radiolabeled compound comprising such a system. The present invention provides an advantage over known methods for evaporation of radioactive fluids because it dramatically reduces the amount of radioactive gaseous chemicals released into the hot cell. The present invention provides access to a radiosynthetic process that is milder and safer than known processes and which could not be tolerated for safety reasons related to the release of volatile radioactive gases during evaporation. In addition, the process yield is higher because the radioactive volatiles are labeled intermediate species.

Process for the preparation of azo dyes in microreactors

Process for preparing fluorobenzene and benzoic acid hypofluorite

A process for the manufacture of a fluorinated benzene starting from benzoic acid by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F 2 ) is preferably present in a high concentration, and subsequent decarboxylation of the benzoic acid hypofluorite obtained by direct fluorination. And a process for the manufacture of a benzoic acid hypofluoriteby direct fluorination of benzoic acid. The fluorination process may be performed batch-wise or in a continuous manner. If the process is performed batch-wise, a column (tower) reactor may be used. If the process is continuous, a micro-reactor may be used.

Microreactor system

It is an object of the present invention to ensure quite high-speed and highly efficient production using the microreactors and facilitate transition from laboratory-basis synthesis to industrial production. A microreactor system collecting a mixture solution obtained by mixing up material solutions in a microreactor includes a plurality of microreactors arranged in parallel; a flowmeter disposed on a downstream side; a detector detecting a composition of the mixture solution; and a processing device calculating both a reaction time from when the material solutions are mixed up until the detector detects the composition of the mixture solution and an yield of the target product. The processing device includes means for changing the amount of each of the material solutions supplied by the pump in each of the microreactors; means for calculating and storing the reaction time and the yield of the target product for every change in the supply amount; and means for deciding which of the plurality of microreactors is selected on the basis of the reaction time and the yield of the target product.

Method for production of azo dyes in microreactors

The invention relates to a method for the production of azo dyes, characterised in that the diazotisation of aromatic or heteroaromatic amines, or the azo coupling reaction, or the diazotisation and the azo coupling reaction are carried out in a microreactor.

Reactor system for high throughput applications

본 발명은 높은 처리량 어플리케이션을 위한 반응기 시스템에 관한 것으로, 상세하게는 각각이 가압 유체를 유동형 반응기에 제공하기에 적합한 유체 공급원, 평면형 마이크로 유체칩을 포함하는 유량 분배기를 포함하는 다수의 반응기 집합체; 을 포함하되, 상기 마이크로 유체칩은 하나의 칩 유입 채널 및 다수의 칩 배출 채널을 가지며, 다수의 유량 제한기 채널을 더 포함하고, 상기 유량 제한기 채널은 칩 유입 채널로부터 연관된 칩 배출 채널로 연장되어 있으며, 상기 칩 유입 채널 및 칩 배출 채널 각각은 일정 직경을 가지며, 상기 칩 유입 채널의 직경은 상기 칩 유입 채널의 길이보다 작거나 같으며, 상기 칩 배출 채널의 직경은 상기 칩 배출 채널의 길이보다 작거나 같은 것을 특징으로 하는 높은 처리량 어플리케이션용 반응기 시스템에 관한 것이다.

Intuitive Graphical User Interface for Carrying Out Chemical Reactions

An apparatus and method for chemical synthesis, the method includes accessing a recipe, the recipe including a sequence of one or more processing steps for the chemical synthesis. The processing steps including one or more steps. The recipe is executed by sorting the processing steps and executing the one or more selected steps prior to executing other steps. The chemical synthesis is monitored by providing status data, indicating a status of the execution and enabling input of control data to modify execution based on the status data or user-initiated modification. Information related to the status of the execution is displayed, typically as a graphical representation of a process action.

Modular continuous flow device

The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.

Reaction unit

本发明提供一种反应装置，其具备被供给反应物并引起该反应物的反应的反应容器，该反应容器具有中空的箱型部件和1个或多个隔板；该箱型部件具有形成有供给上述反应物的流路的第1板、与该第1板相对向的第2板、以及与上述第1板的边缘和上述第2板的边缘相连接而设置的第3板；该隔板被配置为将上述箱型部件内的空间分隔、形成上述反应物流动的反应流路，并具有在相对于上述第2板实质上垂直的方向上设置的隔壁部、和相对于该隔壁部实质上成直角地设置在端部上的接合部，上述接合部接合在上述第2板的内面侧。

Flow type reaction device

本发明所要解决的问题是提供一种流动式反应装置，能够长时间维持足以满足实用化的反应效率和生产率，并且能够实现反应设备的小型化及低成本化，提供一种流动式反应装置(1)，用于使两种以上的原料物质连续反应，包括：混合部(10)，用于混合两种以上的原料物质；和反应部(20)，设置于混合部(10)的二次侧且通过使原料物质反应而得到生成物，混合部(10)具有：混合器(13)，用于混合两种以上的所述原料物质；和两个以上的供给路径(L11、L12)，用于向混合器(13)供给各个原料物质，在混合器(13)上分别连接有供给路径(L11、L12)，并且供给路径(L11)在供给路径(L11)与混合器(13)的连接部分的附近具有抑制机构，该抑制机构抑制流体从混合器(13)向供给路径(L11)移动。

Microchannel structure and method for manufacturing emulsion and solid spherical grain

　供給流体が積層面間を通じて混合物や反応物の流路に滲出することを防止したマイクロチャネル構造体を提供する。また、マイクロチャネル構造体を用いて、高圧の条件下で均一な粒径のエマルションを製造する方法を提供する。　流路となる外部連通孔を有する一対の枠体間に、流路となる切欠き部を有する層の１層以上を積層挟圧して、流体を混合・反応させるためのマイクロチャネルと、マイクロチャネルに流体を供給する流路と、マイクロチャネルから流体を排出する流路と、を形成させてなるマイクロチャネル構造体において、積層面間に滲出した流体をマイクロチャネルを含む流路に混入させないように回収して外部に排出するための滲出流体排出用の流路を有する構成としたことを特徴とするマイクロチャネル構造体。

Apparatus and methods for continuous flow synthesis of semiconductor nanowires

Auto-oxidation production of hydrogen peroxide via oxidation in a microreactor

Microreactor, chemical product manufacturing system and microreactor manufacturing method

In mixing of raw materials having different flow rate ratios (volume ratios) (different flow rates), in order to achieve a good mixing effect, the present invention includes: for raw materials having different flow rates, a high-flow-rate side flow path ( 102 ) through which a raw material on a high-flow-rate side flows; a low-flow-rate side flow path ( 103 ) through which a raw material on a low-flow-rate side flows; branch flow paths ( 102 a, 102 b ) which are branched from the high-flow-rate side flow path; and a residence flow path ( 104 ) which is a flow path after the branch flow paths ( 102 a, 102 b ) and the low-flow-rate side flow path ( 103 ) merge. The branch flow path ( 102 a ) and the branch flow path ( 102 b ) merge in a way of sandwiching the low-flow-rate side flow path ( 103 ).

Flow path structure and method for forming lipid particles to micelles using the same

係提供一種能夠粒徑控制性高地製造例如有用於作為藥物遞輸系統中之奈米尺寸的載體之脂質粒子至微胞之流路構造體及使用該流路構造體之脂質粒子至微胞的形成方法。該流路構造體，係於使原料溶液流動之微尺寸的流路中，從兩側面相互不同地配置複數個既定寬度的構造件(障板)之二維構造的流路構造體。

Microreactor and method for producing same and method for producing a substrate for a microreactor

The substrate (10, 20) of the microreactor comprises first and second layers (11, 21; 12, 22) of ceramic material. The first layer (11, 21) includes a crystalline ceramic and/or a glass in its matrix. It includes a further crystalline ceramic. The hollow chamber structure (14, 24) is formed such that the wall region of the crystals and/or crystal agglomerates of the second component in the first layer (11, 21) are at least locally etched-out. The hollow chamber structure is a pore- or tube structure (i.e. it has porosity). Catalytic material arranged in the hollow chamber structure is coated onto or deposited into it by deposition from the gas phase. The catalyst is selected from: platinum, palladium, nickel and rhodium. The etched hollow chamber structure only exists in a predetermined region of the first layer and reaches a predetermined depth in it. The second component comprises Al 2O 3crystallites and/or a different crystalline compound. Up to 40 vol% of it is contained in the matrix. In the wall regions the crystals and/or crystalline agglomerate preferably contain silicon and/or lead. The substrate has a second layer. The first- and at least one second layer are made using LTCC (low temperature co-fired ceramic) technology. A heater is included in a layer above or below the hollow structure in the first layer. At a wall of the hollow structure where reaction takes place, converting an educt into a product, the educt is caused to flow past this location. Further details of the arrangement are provided. A chemical sensor is included to measure the yield of the conversion process. An independent claim IS INCLUDED FOR the method of making the corresponding microreactor and its substrate.

Residence time modul for microreactors

System and method for rehydrating powder and delivering the rehydrated powder to a reactor

Microfluidic System

The microfluidic system is constituted of modules that comprise one microfluidic unit and one corresponding electric control unit each and that are retained on a rear panel unit next to each other in a row. To prevent the formation of accumulation of ignitable or toxic gas mixtures a fluid conduit for a rinsing fluid extends through the rear panel unit. Branches lead from said fluid conduit to the modules, and said branches flowing into respective distributor compartments that extend vertically across the module height in the modules. Said distributor compartments are delimited in relation to the interior of the respective module by a distributor panel that is provide with openings. The interior of the respective module comprises, on its lower or rear surface, an exit opening for the rinsing fluid.

Reactor with a pathway extension valve

The present invention relate to a reactor comprising: (i) a first reagent release mechanism, (ii) a second reagent release mechanism, and (iii) a reaction area fluid pathway, wherein the reaction area fluid pathway comprises a pathway extension valve, wherein adjusting the pathway extension valve varies the length of the reaction area fluid pathway, and wherein the pathway extension valve comprises a single valve.

Microfluidic system based on active control of flow resistance in microfluidic channels and methods of use thereof

The invention relates to a microfluidic system based on active control of flow resistance and balancing pressures in microfluidic channels and an improved method for disposable microfluidic devices and cartridges for use in, but not limited to, in-vitro diagnostics. The microfluidic system and device of the invention does not utilize mechanical moving parts to control the fluid flow and has no external fluidic connection to the instrument or fluidics controller.

Improved flow synthesis

Reactor system for high throughput applications

The invention pertains to a reactor system for high throughput applications, which reactor system comprises: -a plurality of reactor assemblies, each reactor assembly comprising: -a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow- through reactors, -a flow splitter which flow splitter comprises a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels,which microfluidic chip further comprises a plurality of flow restrictor channels, wherein each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, wherein the chip inlet channel and the chip outlet channels each have a diameter, wherein the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and wherein the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel.

体内使用を意図したリン脂質組成物を混合するためのカートリッジ

本発明は、カートリッジに関する。より具体的には、本発明は、カートリッジ内に保持されたリン脂質組成物を、カートリッジ内で、カートリッジ内に保持された更なる液体と、又は加圧されたガスと混合することができるカートリッジに関する。本発明は更に、そのようなカートリッジと、カートリッジが解放可能に挿入され得るデバイスと、を備える、カートリッジシステムに関し、デバイスは、液体を混合する目的で、カートリッジ内部で液体を移動させるための推進剤として使用される、及び／又は混合されるガスとして使用される、加圧されたガスを提供するように構成されている。

Verfahren zur steuerung des verlaufs einer flüssigkeit in einer mikrofluidischen einheit

一种聚酰亚胺反应装置及其方法

本发明提供一种聚酰亚胺反应装置及其方法，装置包括第一搅拌容器和第二搅拌容器，第一搅拌容器和第二搅拌容器的出料口均通过管道连接微通道反应器的进料口，第一搅拌容器和第二搅拌容器与微通道反应器连接的管道上均设置计量泵，微通道反应器连接反应罐的进料口，反应罐的出料口连接过滤器一端侧，过滤器另一端侧连接离心装置，离心装置连接干燥装置，微通道反应器外侧设置冷却装置。本发明的聚酰亚胺反应装置及其方法，微通道反应器流道尺寸微小，流体传质效率高，换热效率高，该微通道中采用连续流的方式，可以通过调节原料的流速，进而控制在微通道反应器内反应的时间，进而防止存在过反应或欠反应，该微通道反应装置生产效率高，且占地面积小。

Mikroreaktor mit verbessertem wärmetauscher

微反应器系统

本发明提供一种能够高效地利用原料的流体的微反应器系统。微反应器系统(1)具有：微反应器(107)，其具有用于导入流体的两个流入口和使流体汇流的流道，将从一个流入口导入的第1流体和从另一个流入口导入的第2流体在流道中混合；用于准备第1流体的第1容器(101)；用于准备第2流体的第2容器(102)；将第1流体向流入口输送的第1泵(105)；将第2流体向流入口输送的第2泵(106)；第1测量部件(110)，用于测量第1容器(101)内的第1流体的量；第2测量部件(111)，用于测量第2容器(102)内的第2流体的量；和切换部件(112、113)，将向微反应器(107)输送的第1流体和第2流体中的至少一者切换成与第1流体和第2流体不同的流体。

Preparation method of polyurethane foam

A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.

균일한 나노입자 제조를 위한 미세유체장치

본 발명은 소수성 물질과 친수성 물질을 포함하는 나노입자를 제조하는데 유용한 장치에 관한 것이다. 구체적으로, 본 발명의 장치는 소수성 물질과 친수성 물질이 각각 유입되는 복수의 유입 채널, 상기 물질들이 혼합되어 나노입자가 제조되는 혼합 채널, 및 상기 제조된 나노입자가 유출되는 유출 채널을 포함하고, 상기 혼합 채널은 상기 물질의 혼합 효율을 상승시킬 수 있는 미세 기둥을 포함하는 것을 특징으로 한다. 따라서, 본 발명의 장치로 제조된 나노입자는 우수한 입자 균일성을 가지므로, 약물 또는 약물 전달체로 유용하게 사용될 수 있다.

Verweilzeitmodul für mikroreaktoren

Microreactor system

Flow synthesis of polymer nanoparticles

A system and method for flow synthesis of polymer nanoparticles in a continuous flow reactor having a channel. The polymer nanoparticles are synthesized from monomer in the presence of an initiator.

Fluid reactor with thin chip of two-dimensionally distributed micro-resistance units

Autoxidative herstellung von wasserstoffperoxid mittels oxidation in einem mikroreaktor

一种微通道反应器制备精草铵膦及其盐的方法

本发明公开了一种微通道反应器制备精草铵膦及其盐的方法，将式(1)化合物溶液与酸通过微通道反应器进料口连续进料，从背压阀出料口可连续得到固液混合物，经过滤干燥得到精草铵膦及其盐纯品。本发明具有反应时间短、酸用量低、收率高、连续化生产、纯化简单等优点，反应式如下：

Flow synthesis of polymer nanoparticles

Software-reconfigurable conduit and reaction chamber microfluidic arrangements for lab-on-a-chip and miniature chemical processing techologies

Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or smallscale chemical manufacturing.

Microreactor system

A microreactor system includes: a microreactor that has two inflow ports into which fluids are introduced and a flow path configured to merge the fluids, and that is configured to mix a first fluid introduced from one of the inflow ports and a second fluid introduced from the other of the inflow ports in the flow path; a first container in which the first fluid is prepared; a second container in which the second fluid is prepared; a first pump configured to feed the first fluid toward the inflow port; a second pump configured to feed the second fluid toward the inflow port; first and second measurement units configured to measure amounts of the first fluid and the second fluid, respectively; and switching units configured to switch at least one of the first fluid and the second fluid to be fed to the microreactor.

Micro-reactor and method of use

Mikrofluidiksystem

Flow reactor system and flow reaction method

The present disclosure generally relates to a flow reactor system (100) and a flow reaction method (200). The flow reactor system (100) comprises liquid pumps (110) for communicating liquid reagents based on a set of flow conditions, a fluid pump (200) for communicating a carrier fluid that is immiscible with the liquid reagents; a fluidic mixer (130) for mixing the liquid reagents into a liquid mixture, a measurement device (150) for measuring properties of liquid plugs (140) discharged from an outlet (136) of the fluidic mixer (130); and a control module configured for controlling the liquid pumps (110) and adjusting the flow conditions based on the measured properties of the liquid plugs (140), wherein the liquid plugs (140) are representative of different flow conditions.