Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 5613. Отображено 100.
22-11-2012 дата публикации

Method for producing formic acid

Номер: US20120295991A1
Автор: Masaru Nakahara, Nobuyuki Matsubayashi, Yoshiro Yasaka
Принадлежит: Individual

An object of the present invention is providing a method for producing formic acid under mild reaction conditions and by a simple procedure. As a means for achieving the object, the method for producing formic acid of the present invention is characterized by a reaction between carbon dioxide and hydrogen in the presence of an ionic liquid. According to the present invention, it is possible to generate formic acid effectively, because the method does not require that carbon dioxide be brought into a supercritical state and because no basic substances are required to be added to the reaction system.

Подробнее
Номер записи: 1
27-12-2012 дата публикации

Method for producing substituted fluorine-containing olefin

Номер: US20120330072A1
Автор: Masato Ohashi, Sensuke Ogoshi, Takabumi Nagai, Takashi Shibanuma
Принадлежит: Daikin Industries Ltd, Osaka University NUC

This invention relates to a method of reacting fluoroolefin with an organic magnesium compound in the presence of a catalyst comprising nickel or palladium so as to efficiently produce fluoroolefin, such as TFE, in which a fluorine (F) atom or atoms bonded to the sp 2 hybridized carbon atom are substituted with an organic group.

Подробнее
Номер записи: 2
09-05-2013 дата публикации

CONVERSION OF ALCOHOLS

Номер: US20130116481A1
Автор: Dowson George Richard Michael, Wass Duncan Frank
Принадлежит: BP Biofuels UK Limited

A method is described for use in a process for the conversion of an alcohol, the method including the step of contacting a composition comprising a first alcohol with a catalyst composition. Catalyst composition described comprises: i) a source of a Group VIII transition metal; ii) a phosphine ligand of formula PRRR, wherein R, Rand Rare the same or different; and iii) a base. In examples described, the alcohol which is converted comprises ethanol and the product comprises butanol. 1. A method for use in a process for the conversion of an alcohol into a product , the method including the step of contacting a composition comprising a first alcohol with a catalyst composition , in which the catalyst composition comprises:i) a source of a Group VIII transition metal, wherein the Group VIII transition metal is selected from one or more of the group comprising Fe, Ru, Os;{'sup': 1', '2', '3', '1', '2', '3', '1', '2', '3, 'ii) a phosphine ligand of formula PR, RR, wherein R, Rand Rare the same or different, and wherein one or more of R, R, and Rinclude a heteroatom-substituted hydrocarbon group; and'}iii) abase.2. A method according to claim 1 , wherein the phosphine ligand of formula PR claim 1 , RRis a multi-dentate ligand with respect to the Group VIII metal.3. A method according to claim 1 , wherein the heteroatom comprises one or more selected from the group comprising O claim 1 , S claim 1 , N and P.4. A method according to claim 3 , wherein the heteroatom comprises one or more selected from the group comprising N and P.5. A method according to claim 1 , wherein only one of R claim 1 , R claim 1 , and Rinclude a heteroatom-substituted hydrocarbon group.6. A method according to claim 1 , wherein the phosphine ligand comprises a bi-dentate ligand with respect to the Group VIII metal.7. A method according to claim 1 , wherein the phosphine ligand comprises a diphosphine group —[P{link}P]— wherein a linking group {link} has a backbone including fewer than two atoms.8. A ...

Подробнее
Номер записи: 3
06-06-2013 дата публикации

Metal-ligand catalyst formation

Номер: US20130143730A1
Автор: Joan Fraga-Dubreuil, Keith Whiston, Thomas A. Micka, Vinay MEDHEKAR
Принадлежит: Invista North America LLC

As described herein, nickel treated with sulfur provides a surprisingly effective source of nickel atoms for generating nickel-phosphorus-containing ligand complexes useful as hydrocyanation catalysts.

Подробнее
Номер записи: 4
06-06-2013 дата публикации

NICKEL FORM FOR PREPARATION OF CATALYTIC NICKEL-LIGAND COMPLEXES

Номер: US20130144082A1
Автор: FRAGA-DUBREUIL JOAN, Medhekar Vinay, MICKA Thomas A., Whiston Keith
Принадлежит: INVISTA NORTH AMERICA S.A R.L.

A novel nickel particulate form is provided that efficiently forms a zero-valent nickel complex with a phosphorus-containing ligands in an organic liquid to form a hydrocyanation catalyst. Particles in the nickel particulate form comprise nickel crystallites. For example, the nickel particulate form can have a BET Specific Surface Area of at least about 1 m/gm; an average crystallite size less than about 20-25 nm, the nickel particulate form can have at least 10% of the crystallites in the nickel form can have can have a diameter (C10) of less than about 10 nm, and/or there are on average at least about 10surface crystallites per gram nickel. A ratio of BET SSA to C50 for the nickel particulate form can be at least about 0.1×10m/gm and preferably at least about 0.4×10m/gm. Methods of preparation and use are also provided. 1. A nickel particulate form comprising nickel crystallites , wherein the nickel particulate form has a BET Specific Surface Area of at least about 1 m/gm; at least 10% of the nickel crystallites have a size (C10) that is less than about 20 nm; the nickel crystallites have an average crystallite size of no greater than about 100 nm; and the nickel crystallite size distribution span is greater than about 1.0.2. The nickel particulate form of claim 1 , wherein the nickel particulate form has a BET Specific Surface Area/C50 ratio of not less than 0.07×10m/gm.3. The nickel particulate form of claim 1 , wherein the nickel particulate form on average has at least about 10surface crystallites per gram of nickel.4. The nickel particulate form of claim 1 , wherein at least 10% of the particles of the form have a size (D10) of no greater than about 6 μm.5. The nickel particulate form of claim 1 , which has a Laser Diffraction Specific Surface Area of at least about 0.4 m/gm.6. The nickel particulate form of claim 1 , which has a BET Specific Surface Area to D10 ratio of about 0.3×10m/gm to about 10.0×10m/gm.7. The nickel particulate form of claim 1 , which ...

Подробнее
Номер записи: 5
20-06-2013 дата публикации

Polyhedral oligomeric silsesquioxane (poss) bonded ligands and the use thereof

Номер: US20130158282A1
Автор: Andrea Christiansen, Christian Mueller, Dieter Hess, Dieter Vogt, Dirk Fridag, Michèle Janssen, Robert Franke
Принадлежит: Evonik Oxeno GmbH and Co KG

The present invention relates to POSS-modified ligands and to the use thereof in catalytically effective compositions in hydroformylation.

Подробнее
Номер записи: 6
04-07-2013 дата публикации

Chelating Carbene Ligand Precursors and Their Use in the Synthesis of Metathesis Catalysts

Номер: US20130172568A1
Автор: Christopher M. Haar, David E. Gindelberger, Jason K. Woertink, Richard L. Pederson, Yann Schrodi
Принадлежит: Materia Inc

Chelating ligand precursors for the preparation of olefin methathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various methathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene methathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type methathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.

Подробнее
Номер записи: 7
19-09-2013 дата публикации

Metal Complex Compound, Hydrogen Production Catalyst and Hydrogenation Reaction Catalyst Each Comprising the Metal Complex Compound, and Hydrogen Production Method and Hydrogenation Method Each Using the Catalyst

Номер: US20130244865A1
Автор: Muranaka Makoto, Oshiki Toshiyuki
Принадлежит: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

Provided is a catalyst for producing hydrogen, which catalyst has higher performance than conventional catalysts since, for example, it exhibits a certain high level of activity in an aqueous formic acid solution at high concentration even without addition of a solvent, amine and/or the like. The metal phosphine complex is a metal phosphine complex represented by General Formula (1): MH(CO)L, wherein M represents an iridium, iron, rhodium or ruthenium atom; in cases where M is an iridium or rhodium atom, m=3 and n=2, and in cases where M is an iron or ruthenium atom, m=2 and n=3; and the number n of Ls each independently represent a tri-substituted phosphine represented by General Formula (2): PRRR. The catalyst for producing hydrogen comprises the metal phosphine complex as a constituent component. 2. The metal phosphine complex according to claim 1 , wherein the tri-substituted phosphine represented by the General Formula (2) comprises at least one optionally substituted cyclohexyl group or 4-dialkylaminophenyl group.3. The metal phosphine complex according to claim 1 , wherein the tri-substituted phosphine represented by the General Formula (2) is at least one selected from the group consisting of tri(4-dialkylaminophenyl)phosphine claim 1 , di(4-dialkylaminophenyl)phenylphosphine claim 1 , 4-dialkylaminophenyldiphenylphosphine claim 1 , trimethylcyclohexylphosphine claim 1 , methylcyclohexyldicyclohexylphosphine claim 1 , dicyclohexyl(4-dialkylaminophenyl)phosphine and cyclohexyldi(4-dialkylaminophenyl)phosphine.4. A catalyst for producing hydrogen by the formic acid decomposition reaction (HCOOH→H+CO) claim 1 , the catalyst comprising as a constituent component the metal phosphine complex according to .5. The catalyst for producing hydrogen according to claim 4 , further comprising as a constituent component an amine or a phosphine.6. The catalyst for producing hydrogen according to claim 5 , wherein the amine is at least one amine selected from the group ...

Подробнее
Номер записи: 8
26-09-2013 дата публикации

NOVEL CATALYSTS

Номер: US20130253185A1
Автор: Lundgren Rylan J., Stradiotto Mark
Принадлежит: DALHOUSIE UNIVERSITY

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions. 2. The compound of claim 1 , wherein both of Rand Rare tert-butyl claim 1 , cyclohexyl claim 1 , 2-tolyl claim 1 , or 1-adamantyl.3. The compound of claim 2 , wherein both of Rand Rare tert-butyl or 1-adamantyl.4. (canceled)5. (canceled)6. The compound of claim 1 , wherein R claim 1 , R claim 1 , and the nitrogen atom to which they are attached form an optionally substituted 4-10 membered heterocyclic ring.9. The compound of claim 1 , wherein each of Xand Xis C—R claim 1 , and each of Xand Xis C—R claim 1 , wherein each Ris independently selected from —H claim 1 , —CH claim 1 , —OCH claim 1 , halogen claim 1 , or —CF claim 1 , and each Ris independently selected from —H claim 1 , —CH claim 1 , —OCH claim 1 , —N(CH) claim 1 , halogen claim 1 , or —CF; or a vicinal Rgroup and Rgroup together with the carbon atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic or carbocyclic ring.10. The compound of claim 9 , wherein each of X claim 9 , X claim 9 , X claim 9 , and Xis C—H.12. (canceled)13. The compound of claim 11 , wherein R claim 11 , R claim 11 , and the nitrogen atom to which they are attached form an optionally substituted 4-10 membered heterocyclic ring.16. The compound of claim 11 , wherein each of Xand Xis C—R claim 11 , and each of Xand Xis C—R claim 11 , wherein each Ris independently selected from —H claim 11 , —CH claim 11 , —OCH claim 11 , halogen claim 11 , or —CF claim 11 , and each Ris independently selected from —H claim 11 , —CH claim 11 , —OCH claim 11 , —N(CH) claim 11 , halogen claim 11 , or —CF; or a vicinal Rgroup and Rgroup together with the carbon atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic or ...

Подробнее
Номер записи: 9
26-09-2013 дата публикации

METHODS FOR RECOVERY AND RECYCLE OF RUTHENIUM HOMOGENOUS CATALYSTS

Номер: US20130253232A1
Автор: Barnicki Scott Donald, Hampton, JR. Kenneth Wayne, Kanel Jeffrey Scott
Принадлежит: EASTMAN CHEMICAL COMPANY

Disclosed is a process for the extractive recovery of a homogeneous ruthenium catalyst from the reaction product of the hydrogenation of glycolic acid, glycolate esters, and/or glycolic acid oligomers with an extractant comprising a hydrophobic solvent and an optional hydrophilic solvent. The ruthenium catalyst, which can include 1,1,1-tris(diaryl- or dialkylphosphinomethyl)alkane ligands, can be recovered from the hydrophobic extract phase by back extraction with a hydrophilic solvent and recycled to a process for the preparation of ethylene glycol by the hydrogenation of glycolic acid and glycolic acid derivatives. 1. A process for recovering a homogeneous catalyst , comprising(A) contacting an aqueous mixture comprising glycolic acid, glycolate esters, methyl glycolate, oligomers of glycolic acid, or mixtures thereof, with hydrogen in the presence of a catalyst composition comprising ruthenium and tris-1,1,1-(diphenylphosphinomethyl)ethane to form a glycolic acid hydrogenation product comprising about 50 to about 90 weight percent, based on the total weight of said glycolic acid hydrogenation product, ethylene glycol, about 0.5 to about 25 weight percent water, and about 0.5 to about 30 weight percent of one or more reaction by-products selected from glycolic acid, oligomers of glycolic acid, and glycolate esters of ethylene glycol, and said catalyst composition;(B) extracting said glycolic acid hydrogenation product with a first extractant, comprising about 60 to 100 weight percent, based on the total weight of said first extractant, 2-ethylhexanol and about 0 to about 40 weight percent of a hydrocarbon having 5 to 20 carbon atoms to form a first raffinate phase comprising a major amount of said ethylene glycol contained in said glycolic acid hydrogenation product and a first extract phase comprising a major amount of said catalyst composition contained in said glycolic acid hydrogenation product;(C) separating said first raffinate and extract phases;(D) ...

Подробнее
Номер записи: 10
24-10-2013 дата публикации

Novel ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof

Номер: US20130281664A1
Автор: Boopathy Gnanaprakasam, Chidambaram Gunanathan, David Milstein, Ekambaram Balaraman, Jing Zhang
Принадлежит: Yeda Research and Development Co Ltd

The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

Подробнее
Номер записи: 11
24-10-2013 дата публикации

PALLADIUM CATALYST, METHOD FOR ITS PREPARATION AND ITS USE

Номер: US20130281700A1
Автор: DALICZEK Zoltán, FINTA Zoltán, SOÓS Tibor, Timári Géza, Vlád Gábor
Принадлежит:

The invention relates to palladium(0)-tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. 2. The composition of in a solid form.3. The composition of having a melting point of 220° C. as determined by DSC in inert atmosphere.4. The composition of claim 1 , having a decomposition point of 169.5° C. as determined by DSC in air under atmospheric pressure.5. A palladium(0) complex comprising three fluorinated phosphine compounds.6. The palladium(0) complex of exhibiting a stability characterized by no measurable decomposition on the basis of P claim 5 , F claim 5 , C and H NMR spectra following 4 months of storage in air at a temperature of 25° C.7. The palladium(0) complex of exhibiting a stability characterized by no measurable decomposition on the basis of P claim 5 , F claim 5 , C and H NMR spectra following 20 months of storage in air at room temperature.8. The palladium(0) complex of having a melting point in inert atmosphere of 220° C.9. The palladium(0) complex of exhibiting stability at any temperature below its melting point.10. The palladium(0) complex of exhibiting insolubility in water at industrially relevant temperatures and stability when stored in water.11. The palladium(0) complex of comprising a yellow solid.12. The palladium(0) complex of that dissolves at around 90° C. in aqueous alcohols.13. The palladium(0) complex of having catalytic activity in cross coupling reactions at a concentration of from 0.1 to 0.3 mole % of the substrate.14. A method for catalysing a C—C claim 5 , C-heteroatom claim 5 , or hydrogenation reaction comprising carrying out the C—C claim 5 , C-heteroatom or hydrogenation reaction in the presence of the palladium(0) complex of .15. The method of claim 14 , wherein the reaction is a C—C cross-coupling reaction.16. The method of claim 14 , wherein the C—C cross-coupling reaction is selected from the group consisting of: Suzuki coupling claim 14 , Heck coupling and ...

Подробнее
Номер записи: 12
28-11-2013 дата публикации

CATALYST COMPOSITIONS FOR HYDROFORMYLATION REACTION AND HYDROFORMYLATION PROCESS USING THE SAME

Номер: US20130317256A1
Автор: CHOI Jae Hui, Eom Sung Shik, KO Dong Hyun, Kwon O Hak, YANG Hye Won
Принадлежит: LG CHEM, LTD.

Disclosed are a catalyst composition for hydroformylation of olefin compounds, comprising a specific phosphine ligand and a transition metal catalyst, and a hydroformylation process using the same. Through a hydroformylation process using the catalyst composition according to the present invention, a suitable selectivity of iso-aldehyde can be maintained, catalyst stability can be improved, the amount of used ligand can be reduced and superior catalyst activity can be obtained. 1. A catalyst composition for hydroformylation comprising a monodentate phosphine ligand and a transition metal catalyst ,wherein the monodentate phosphine ligand is at least one selected from cyclohexyldiphenylphosphine, cyclohexylditolylphosphine and cycloheptyldiphenylphosphine.2. The catalyst composition according to claim 1 , wherein the content of the monodentate phosphine ligand is 0.5 to 200 moles claim 1 , with respect to one mole of the central metal of the transition metal catalyst claim 1 ,{'sub': 2', '8', '2', '3', '2', '3, 'wherein the transition metal catalyst is at least one selected from the group consisting of cobaltcarbonyl [Co(CO)], acetylacetonatodicarbonylrhodium [Rh(AcAc)(CO)], acetylacetonatocarbonyltriphenylphosphinerhodium [Rh(AcAc)(CO)(TPP)], hydridocarbonyltri(triphenylphosphine)rhodium [HRh(CO)(TPP)], acetylacetonatodicarbonylirridium [Ir(AcAc)(CO)] and hydridocarbonyltri(triphenylphosphine)iridium [HIr(CO)(TPP)].'}3. The catalyst composition according to claim 1 , wherein the catalyst composition comprises 1.6 to 3.0% by weight of cyclohexyldiphenylphosphine as the monodentate phosphine ligand claim 1 , with respect to the total weight of the catalyst composition.4. The catalyst composition according to claim 1 , wherein the catalyst composition comprises 1.5 to 1.8% by weight of cyclohexyldiphenylphosphine as the monodentate phosphine ligand claim 1 , with respect to the total weight of the catalyst composition.5. The catalyst composition according to claim 1 , ...

Подробнее
Номер записи: 13
12-12-2013 дата публикации

Novel Compound, Novel Ligand, Novel Transition Metal Complex, and Catalyst Including Novel Transition Metal Complex

Номер: US20130331576A1
Автор: Ko Aram, Korenaga Toshinobu, SAKAI Takashi
Принадлежит: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

The invention provides novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. A ligand of the invention includes a compound represented by General Formula (1): RRRA or General Formula (2): RRA-Y-ARRand having a total of 15 to 110 carbon atoms. In the formulae, A is phosphorus or arsenic; R, R, Rand Rare each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene. 1. A compound represented by General Formula (1) or (2) and having a total of 15 to 110 carbon atoms:{'br': None, 'sup': 1', '2', '3, 'RRRA\u2003\u2003(1)'}{'br': None, 'sup': 1', '2', '3', '4, 'RRA-Y-ARR\u2003\u2003(2)'}{'sup': 1', '2', '3', '4, 'sub': '2-20', '(wherein A is phosphorus or arsenic; R, R, Rand Rare each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene).'}2. The compound according to claim 1 , wherein the electron-withdrawing group is at least one selected from the group consisting of a perhaloalkyl group having 1 to 4 carbon atoms claim 1 , a halogen claim 1 , nitro group claim 1 , cyano group claim 1 , pentafluorophenyl group claim 1 , tetrafluoropyridyl group claim 1 , heptafluorotolyl group claim 1 , 2 claim 1 ,6- ...

Подробнее
Номер записи: 14
19-12-2013 дата публикации

METHOD FOR MANUFACTURING RUTHENIUM CARBENE COMPLEXES

Номер: US20130338370A1
Автор: Kadyrov Renat, Rosiak Anna
Принадлежит: EVONIK DEGUSSA GmbH

The invention is directed to aryl alkylidene ruthenium complexes and the use of these complexes as catalysts in metathesis reactions. 112-. (canceled)14. The Ru-carbene complex according to claim 13 , wherein L and L′ are selected independently from the group consisting of triphenylphosphane claim 13 , triisopropylphosphane claim 13 , tricyclohexylphosphane and 9-cyclohexyl-9-phosphabicyclo[3.3.1]nonane.15. The Ru-carbene complex according to claim 13 , wherein L is a heterocyclic carbene and L′ is selected from the group consisting of triphenylphosphane claim 13 , triisopropylphosphane claim 13 , tricyclohexylphosphane and 9-cyclohexyl-9-phospha-bicyclo[3.3.1]nonane.16. The Ru-carbene complex according to claim 13 , wherein Ar is a furyl or thienyl radical.17. (canceled)1830. A metathesis reaction which comprises utilizing the Ru-carbene complex according to claim as a catalyst in the metathesis reaction.19. The Ru-carbene complex according to claim 13 , wherein X is halogen claim 13 , pseudo-halogen claim 13 , carboxylate claim 13 , sulphate or diketonate.20. The Ru-carbene complex according to claim 13 , wherein X is bromine or chlorine.21. The Ru-carbene complex according to claim 13 , wherein X is chlorine.22. The Ru-carbene complex according to claim 19 , wherein L is a heterocyclic carbene and L′ is selected from the group consisting of triphenylphosphane claim 19 , triisopropylphosphane claim 19 , tricyclohexylphosphane and 9-cyclohexyl-9-phospha-bicyclo[3.3.1]nonane.23. The Ru-carbene complex according to claim 22 , wherein Ar is a furyl or thienyl radical.24. The Ru-carbene complex according to claim 21 , wherein L is a heterocyclic carbene and L′ is selected from the group consisting of triphenylphosphane claim 21 , triisopropylphosphane claim 21 , tricyclohexylphosphane and 9-cyclohexyl-9-phospha-bicyclo[3.3.1]nonane.25. The Ru-carbene complex according to claim 24 , wherein Ar is a furyl or thienyl radical. This application is a Division of application ...

Подробнее
Номер записи: 15
09-01-2014 дата публикации

PROCESS FOR PREPARING A PROPIOLIC ACID OR A DERIVATIVE THEREOF

Номер: US20140012000A1
Автор: Goossen Lukas J, Lange Paul P., Manjolinho Costa Filipe, Rodriguez Garrido Nuria
Принадлежит: BASF SE

The invention relates to a process for preparing a propiolic acid or a derivative thereof by reacting a terminal alkyne with carbon dioxide, which comprises performing the reaction in the presence of a base and a copper complex, especially a copper (I) complex having at least one ligand, at least one of the ligands of the copper complex being selected from monodentate ligands which have an aminic or iminic nitrogen atom capable of coordination with copper, and polydentate ligands having at least two atoms or atom groups which are capable of simultaneous coordination with copper and are selected from nitrogen, oxygen, sulfur, phosphorus and carbene carbon. 1: A process for preparing a propiolic acid or a derivative thereof , the process comprising:reacting a terminal alkyne with carbon dioxide in the presence of a base and a copper complex comprising a ligand, whereinthe ligand is a monodentate ligand or a polydentate ligandthe monodentate ligand comprises an amine or imine nitrogen atom, and is capable of coordinating to copper,the polydentate ligand comprises at least two atoms or atom groups, which are capable of coordinating simultaneously to copper, andthe atoms or atom groups are at least one selected from the group consisting of nitrogen, oxygen, sulfur, phosphorus and carbene carbon.2: The process according to claim 1 , wherein the terminal alkyne is a compound of formula:{'br': None, 'sup': 'x', 'R—C≡C—H,'}wherein{'sup': x', 'x1', 'x3', 'x3', 'x4', 'x4', 'x4', 'x4', 'x2, 'sub': '3', 'Ris selected from the group consisting of a hydrogen, a COOR, an alkyl optionally substituted by one or more substituents R, an alkenyl optionally substituted by one or more substituents R, a cycloalkyl optionally substituted by one or more substituents R, a heterocycloalkyl optionally substituted by one or more substituents R, an aryl optionally substituted by one or more substituents R, a hetaryl optionally substituted by one or more substituents R, and a (R)Si,'}{'sup': x1', ...

Подробнее
Номер записи: 16
09-01-2014 дата публикации

New palladium catalyst, method for its preparation and its use

Номер: US20140012004A1
Автор: Gábor Vlád, Géza Timári, Tibor SOÓS, Zoltán DALICZEK, Zoltán Finta
Принадлежит: H4SEP KFT

The invention relates to palladium(0) tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.

Подробнее
Номер записи: 17
20-02-2014 дата публикации

CYCLOPROPENYLIDENE-STABILIZED PHOSPHENIUM CATIONS

Номер: US20140051870A1
Автор: ALCARAZO Manuel, Bruns Hans, Petuskova Jekaterina
Принадлежит:

Phosphenium compounds with the general formula I: 2. The phosphenium compound as claimed in claim 1 , wherein R claim 1 , R claim 1 , Rand R claim 1 , each independently of one another claim 1 , are chosen from isopropyl and tert-butyl.3. The phosphenium compound as claimed in wherein Xis chosen from BF claim 1 , PF claim 1 , SbFand/or BPh.5. The process as claimed in claim 4 , wherein X represents chlorine.6. A metal complex comprising the phosphenium compound with the general formula I as claimed in as a ligand.8. The metal complex as claimed in claim 7 , wherein the ligands L are chosen from halogen claim 7 , CN claim 7 , CO claim 7 , alkenes claim 7 , cycloalkenes and/or alkynes.9. The metal complex as claimed in claim 7 , wherein MLrepresents AuCl claim 7 , AuCl claim 7 , PdCl(allyl) claim 7 , RhCl(cod) claim 7 , RhCl(CO) claim 7 , CuCl claim 7 , RhCland/or BH.10. A cycloisomerization reaction catalyzed by the metal complex as claimed in . The present invention relates to novel stabilized cyclopropenylylidene cations and their use as ligands in metal catalysts.Phosphenium cations of the general formula [RP:]are isolobal with singlet carbenes and can be stabilized, for example, by donation of electron density in their empty orbital. This stabilization can, for example, be achieved by incorporation of the phosphorus atom in a heterocyclic backbone A or by reaction with bases with the formation of the corresponding Lewis adduct B (scheme 1).In both cases, the presence of a free electron pair on the phosphorus atom suggests the use of these compounds as ligands, though their intrinsic positive charge results in them being weak a donors and strong Π acceptors. In particular, in the adducts of type B, the resonance structure of Bdominates in the basic structure, if D is a phosphine, so that transition metal complexes, which can be derived from these compounds, are rare. Even in cases in which D is an N-heterocyclic carbene (NHC), the coordination properties of the ...

Подробнее
Номер записи: 18
02-01-2020 дата публикации

Immobilized Ruthenium-Triphos Catalysts for Selective Hydrogenolysis of Amides

Номер: US20200001286A1
Автор: Hembre Robert Thomas, KLANKERMAYER Jürgen, Leitner Walter, ROSEN Andreas, WESTHUES Stefan
Принадлежит: EASTMAN CHEMICAL COMPANY

A compound represented by the structure of formula (I): 5. The compound of claim 4 , wherein L comprises trimethylenemethane.7. The method of claim 6 , wherein the Ru-containing compound comprises [Ru(COD)(methylallyl)].8. A catalyst composition comprising:(a) an oxidic support; and{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, '(b) the compound of immobilized on the support.'}9. The catalyst composition of claim 8 , wherein the oxidic support comprises silica claim 8 , magnesia claim 8 , titania claim 8 , or alumina.10. The catalyst composition of claim 8 , wherein the oxidic support comprises silica.11. The catalyst composition of claim 8 , wherein L comprises trimethylenemethane.13. The process of claim 12 , wherein the oxidic support comprises silica claim 12 , magnesia claim 12 , titania claim 12 , and alumina.14. The process of claim 12 , wherein the oxidic support comprises silica.15. The process of claim 12 , wherein L comprises trimethylenemethane.16. The process of claim 13 , wherein L comprises trimethylenemethane.17. The process of claim 14 , wherein L comprises trimethylenemethane.18. The process of claim 12 , wherein the amide comprises a lactam.19. The process of claim 13 , wherein the amide comprises a lactam.20. The process of claim 17 , wherein the amide comprises a lactam. This is application claims the benefit of Provisional Application No. 62/691,936 filed on Jun. 29, 2018 under 35 U.S.C. § 119(e)(1); the entire content of the provisional application is hereby incorporated by reference.The invention generally relates to the field of organic chemistry. It particularly relates to silyl ether triphos compounds, organometallic complexes containing the silyl ether triphos compounds, catalysts containing the organometallic complexes immobilized on oxidic supports, methods of making, and/or methods of using the compounds, complexes, and catalysts.The hydrogenolysis of amides to amines under mild reaction conditions represents a challenging chemical ...

Подробнее
Номер записи: 19
03-01-2019 дата публикации

CATALYTIC COMPOSITION COMPRISING NICKEL, A PHOSPHINE-TYPE LIGAND AND A LEWIS BASE, AND USE THEREOF IN AN OLEFIN OLIGOMERISATION METHOD

Номер: US20190001317A1
Автор: BREUIL Pierre-Alain, CHAUMET-MARTIN Olivia
Принадлежит: IFP ENERGIES NOUVELLES

The invention concerns a catalytic composition comprising: at least one nickel precursor with an oxidation number of (+II), at least one phosphine ligand with formula PRRRin which the groups R, Rand R, which may be identical or different and which may or may not be bonded together, and at least one Lewis base, said composition having a molar ratio of the phosphine ligand to the nickel precursor of less than or equal to 5 and a molar ratio of the Lewis base and phosphine ligand together to the nickel precursor of greater than or equal to 5. 1. A catalytic composition comprising:at least one nickel precursor with an oxidation number of (+II),{'sup': 1', '2', '3', '1', '2', '3, 'claim-text': 'aromatic groups which may or may not be substituted and which may or may not contain heteroelements,', 'at least one phosphine ligand with formula PRRRin which the groups R, Rand R, which may be identical or different, and which may or may not be bonded together, are selected from'}and/or from hydrocarbyl groups, which may or may not be cyclic, which may or may not be substituted and which may or may not contain heteroelements,and at least one Lewis base,said composition having a molar ratio of the phosphine ligand to the nickel precursor of less than or equal to 5 and a molar ratio of the Lewis base and phosphine ligand together to the nickel precursor of greater than or equal to 5.2. The composition as claimed in claim 1 , in which the molar ratio of the phosphine ligand to the nickel precursor is in the range 2 and 5.3. The composition as claimed in claim 1 , in which the nickel precursor is selected from nickel(II) chloride; nickel(II) (dimethoxyethane) chloride;nickel(II) bromide; nickel(II) (dimethoxyethane) bromide; nickel(II) fluoride; nickel(II) iodide; nickel(II) sulphate; nickel(II) carbonate; nickel(II) dimethylglyoxime; nickel(II) hydroxide; nickel(II) hydroxyacetate; nickel(II) oxalate; nickel(II) carboxylates selected from the group formed by nickel(II) 2- ...

Подробнее
Номер записи: 20
05-01-2017 дата публикации

PROCESS OF PRODUCTION OF 2,5-DIMETHYLPHENOL

Номер: US20170001935A1
Автор: Bonrath Werner, Letinois Ulla, Netscher Thomas
Принадлежит:

The present invention relates to a new method to produce 2,5-dimethylphenol (2,5-DMP). 2. Process according to claim 1 , wherein the catalyst is an Au(I) complex.6. A process according claim 3 , wherein the Au(I) complex is added to reaction mixture as such.7. Process according to claim 3 , wherein the Au(I) complex is formed in situ in the reaction mixture.8. Process according to claim 1 , wherein the substrate to catalyst ratio is 2:1 to 10000:1 claim 1 , preferably are 10:1 to 3000:1 The present invention relates to a new method to produce 2,5-dimethylphenol (2,5-DMP).2,5-dimethylphenol, which is also called 2,5 xylenol, can be used for example as an intermediate in the production of vitamin E.Xylenols are organic compounds with the formula (I)They are volatile colorless solids or oily liquids. They are derivatives of phenol with two methyl groups and a hydroxyl group. Six isomers are existing.Together with many other compounds, xylenols are traditionally extracted from coal tar, the volatile materials obtained in the production of coke from coal. These residues contain a few percent by weight of xylenols as well as cresols and phenol.Together with cresols and cresylic acid, xylenols are an important class of phenolics with great industrial importance. They are used in the manufacture of antioxidants. Xylenol orange is a redox indicator built on a xylenol skeleton. 2,5-DMP, which is the compound of formula (Ia)is an intermediate in the production of the 2,3,6-trimethylphenol (2,3,6-TMP) which is the compound of formula (II)2,3,6-TMP is usually produced by a gasphase methylation of 2,5-DMP.2,3,6-TMP can be used as such (for example in cosmetic formulations) as well as intermediate in the production of other organic compounds, such as for example vitamin E.Due to fact that of 2,5-DMP is obtained from not renewable resources, an alternative, more sustainable production of 2,5-DMP is desirable.We now found a new way for the production of 2,5-DMP, which is carried out ...

Подробнее
Номер записи: 21
03-01-2019 дата публикации

Photocatalytic Conversion of Carbon Dioxide and Water Into Substituted or Unsubstituted Hydrocarbon(s)

Номер: US20190002364A1
Автор: ANDERSSON Gunther, GOLOVKO Vladimir, METHA Gregory F, NANN Thomas
Принадлежит:

A method for the production of hydrocarbon(s), such as methane, substituted hydrocarbons, such as methanol, or the production of hydrogen, the method comprising the steps of contacting a first catalyst with water in order to photocatalyse the splitting of at least some of the water into hydrogen and oxygen; and contacting a second catalyst with a gas stream comprising carbon dioxide and at least some of the hydrogen produced from step (a) in order to photocatalyse the reaction between the hydrogen and carbon dioxide to produce hydrocarbon(s), such as methane, and/or substituted hydrocarbons, such as methanol. In an embodiment, the catalyst comprises gold and or ruthenium nanoclusters supported on a substrate. 1. A method for the production of hydrocarbon(s) , such as methane , or substituted hydrocarbons , such as methanol , the method comprising the steps of:contacting a catalyst with water and carbon dioxide in the presence of light in order to photocatalyse:(i) the splitting of at least some of the water into hydrogen and oxygen; and(ii) the reaction between hydrogen and carbon dioxide to produce at least one of a hydrocarbon and/or substituted hydrocarbons;wherein the catalyst comprises at least gold and ruthenium, in the form of at least one nanocluster supported by a substrate.2. The method according to claim 1 , wherein support substrate is selected from the group comprising graphene claim 1 , graphite claim 1 , carbon black claim 1 , nanotubes claim 1 , fullerenes claim 1 , zeolites claim 1 , carbon nitrides claim 1 , metal nitrides and or oxides including zinc oxide or titanium oxide.3. The method according to claim 1 , wherein the gold and ruthenium nanocluster has at least one Au—Ru bond having a distance in the range of from about 2.5 to 3.0 Å.4. The method according to claim 1 , wherein the gold and ruthenium nanocluster comprise an average cluster size less than about 2 nm.5. A method for the production of hydrocarbon(s) claim 1 , such as methane claim ...

Подробнее
Номер записи: 22
04-01-2018 дата публикации

Processes for the preparation of a diarylthiohydantoin compound

Номер: US20180002309A1
Автор: Andras Horvath, Cyril Ben Haim, Jennifer Albaneze-Walker, Johan Erwin Edmond
Принадлежит: Aragon Pharmaceuticals Inc

Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.

Подробнее
Номер записи: 23
02-01-2020 дата публикации

SYNTHESIS OF COELENTERAZINE

Номер: US20200002344A1
Автор: Bhatt Rama, Duvvuru Rajagopala Reddy, Kumar Anil
Принадлежит: INTERNATIONAL PAPER COMPANY

Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products. 1. A method of making coelenterazine , comprising:(a) reacting 3-benzylpyrazin-2-amine (25) with N-bromosuccinimide to provide 3-benzyl-5-bromopyrazin-2-amine (2);(b) reacting the 3-benzyl-5-bromopyrazin-2-amine (2) in two sequential steps to provide 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7) (coelenteramine); and(c) coupling the 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7) with silyl-protected 1,1-diethoxy-3-(4-hydroxyphenyl)propan-2-one to provide coelenterazine, or a salt thereof.2. The method of claim 1 , wherein (a) provides 3-benzyl-5-bromopyrazin-2-amine (2) in a yield of 60% to 85% relative to 3-benzylpyrazin-2-amine (25) and in a purity of at least 85%.3. The method of claim 1 , wherein (b) comprises a first step of reacting the 3-benzyl-5-bromopyrazin-2-amine (2) with 4-methoxyphenyl boronic acid (4) in the presence of a palladium catalyst to provide 3-benzyl-5-(4-methoxyphenyl)pyrazin-2-amine (5).4. The method of claim 3 , wherein the palladium catalyst is tetrakis(triphenylphosphine)palladium(0).5. The method of or claim 3 , wherein the palladium catalyst is present in an amount of 5 to 10 percent by weight relative to the 3-benzyl-5-bromopyrazin-2-amine (2).6. The method of any one of to claim 3 , wherein the first step in (b) comprises 1:1 to 1:1.3 molar equivalent of the 3-benzyl-5-bromopyrazin-2-amine (2) to 4-methoxyphenyl boronic acid (4).7. The method of any one of to claim 3 , wherein the first step in (b) comprises reacting the 3-benzyl-5-bromopyrazin-2-amine (2) and the 4-methoxyphenyl boronic acid (4) for a duration of 120 minutes to 300 minutes.8. The method of any one of to claim 3 , wherein the first step in (b) comprises reacting the 3-benzyl-5-bromopyrazin-2-amine (2) and the 4-methoxyphenyl boronic ...

Подробнее
Номер записи: 24
04-01-2018 дата публикации

ALKANE DEHYDROGENATION PROCESS

Номер: US20180002361A1
Автор: Goldman Alan S., Kumar Akshai, Mironov Oleg, Saxton Robert J.
Принадлежит:

Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex. In the dehydrogenation reactions, hydrogen that is co-formed during the process must be removed for the chemical reaction to proceed and to prevent the excess hydrogen from poisoning the catalyst. In one embodiment the process comprises providing an alkane feedstock comprising at least one alkane and contacting the alkane with an iridium pincer complex in the presence of a hydrogen acceptor selected from the group consisting of ethylene, propene, or mixtures to form an alkene product. The processes disclosed herein can accomplish facile, low-temperature transfer dehydrogenation of alkanes with unprecedented selectivities and TONs at a reasonable rate of conversion. 1. A process for preparing alpha-olefins from an at least one alkane , comprising the steps of:providing an alkane feedstock in a gaseous phase comprising the at least one alkane;contacting the at least one alkane in the gaseous phase with an iridium pincer complex in the presence of a gaseous hydrogen acceptor selected from the group consisting of ethylene, propene, and mixtures thereof; andrecovering an alpha-olefin product.2. The process of claim 1 , wherein the at least one alkane in the gaseous phase is selected from the group consisting of a butane claim 1 , a pentane claim 1 , an octane claim 1 , a nonane claim 1 , a decane claim 1 , a dodecane claim 1 , and mixtures thereof.5. The process of claim 1 , wherein the iridium pincer complex is (PCP)Ir(CH) or (p-OK-PCP)Ir(CH).6. The process of claim 1 , wherein the iridium pincer complex is unsupported.7. The process of claim 1 , wherein the iridium pincer complex is immobilized on a solid support.8. The process of claim 7 , wherein the solid support is selected from the group consisting of a silica claim 7 , a γ-alumina claim 7 , a basic alumina claim 7 , a florisil claim 7 , and a neutral alumina.9. The process of claim 8 , wherein the solid ...

Подробнее
Номер записи: 25
11-01-2018 дата публикации

METHOD FOR REDUCTION OF ORGANIC MOLECULES

Номер: US20180008972A1
Автор: KLANKERMAYER Jürgen, Leitner Walter, Meuresch Markus
Принадлежит: RHEINISCH-WESTFÄLISCHE TECHNISCHE (RWTH) AACHEN

A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted. 1. A method for the reduction of organic molecules , comprising the step ofa) hydrogenating at least one organic molecule in the presence of a Ruthenium-Triphosphine-complex whereby the triphosphine-complex comprises at least one aryl and/or heteroaryl moeity bound to a phosphine which is substituted in ortho and/or meta position to the phosphine.2. The method according to claim 1 , wherein the Ruthenium-Triphosphine-complex comprises a phosphororganic compound where two or all three phosphors have an aryl and/or heteroaryl moeity which is substituted in ortho and/or meta position to the phosphine bound thereto.4. The method according to claim 1 , wherein step a) is performed under acidic conditions.5. The method according to claim 1 , wherein step a) is performed under acidic conditions whereby the (initial) concentration of acid is ≧0.5 to ≦20 times the concentration of Ruthenium (in mol:mol).6. The method according to claim 5 , wherein step a) is performed under acidic conditions whereby the acid is selected out of the group comprising sulfonic acids claim 5 , especially methanesulfonic acid claim 5 , trifluormethansulfonic acid claim 5 , p-toluolsulfonic acid claim 5 , p-bromobenzosulfonic acid claim 5 , p-nitrobenzosulfonic acid claim 5 , sulfuric acid claim 5 , hydrochloric acid claim 5 , hydrofluoric acid claim 5 , trifluoracetic acid claim 5 , perchloric acid claim 5 , bis(trifluoromethane)sulfonimide or mixtures thereof7. The method according to claim claim 5 , wherein step a) is carried out at an initial hydrogen pressure of ≧1 bar.8. The method according to claim 1 , wherein step a) is carried out in a dipolar protic or aprotic solvent or in CO The present invention relates to a method for reducing organic molecules, especially by using Ruthenium-Triphosphine-complexes.In the prior art, e.g. ...

Подробнее
Номер записи: 26
27-01-2022 дата публикации

Synthesis of (S)-6-Hydroxytryptophan and Derivatives Thereof

Номер: US20220024870A1
Автор: Christoph Müller, Susanne Werner-Simon, Werner Simon
Принадлежит: Heidelberg Pharma Research GmbH

The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.

Подробнее
Номер записи: 27
14-01-2021 дата публикации

ENANTIOSELECTIVE HYDROGENATION OF 4-SUBSTITUTED 1,2-DIHYDROQUINOLINES IN PRESENCE OF A CHIRAL IRIDIUM CATALYST

Номер: US20210009521A1
Автор: BROHM Dirk Eckart, SCHOTES Christoph, SCHRANCK Johannes
Принадлежит: Bayer Aktiengesellschaft

The invention relates to a process for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines comprising enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in presence of a chiral iridium (P,N)-ligand catalyst. 2: The process according to claim 1 , wherein{'sup': '1', 'sub': 1', '6', '6', '14', '1', '4, 'claim-text': {'sub': 6', '14', '6', '14', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4, 'wherein C-C-aryl in the C-C-aryl-C-C-alkyl moiety is unsubstituted or substituted by one to five substituents selected from the group consisting of halogen, C-C-alkyl, C-C-haloalkyl, C-C-alkoxy and C-C-haloalkoxy'}, 'Ris C-C-alkyl or C-C-aryl-C-C-alkyl,'}{'sup': 2', '3, 'sub': 1', '4, 'Rand Rare the same and are selected from C-C-alkyl,'}{'sup': '4', 'sub': 1', '4', '1', '4', '1', '4', '1', '4, 'Ris C-C-alkyl, C-C-haloalkyl, C-C-alkoxy, C-C-haloalkoxy, phenyl or benzyl,'}n is 0, 1 or 2, and{'sup': '5', 'sub': 1', '6', '1', '6, 'each substituent R, if present, is independently selected from the group consisting of halogen, C-C-alkyl and C-C-haloalkyl.'}3: The process according to claim 1 , wherein{'sup': '1', 'Ris methyl, ethyl or n-propyl,'}{'sup': 2', '3, 'Rand Rare methyl,'}{'sup': '4', 'sub': 1', '4, 'Ris C-C-alkyl,'}n is 0, 1 or 2, and{'sup': '5', 'sub': 1', '6, 'each substituent R, if present, is independently selected from the group consisting of halogen and C-C-alkyl.'}6: The process according to claim 1 , wherein the hydrogenation is conducted using hydrogen gas at a pressure of from 1 to 300 bar.7: The process according to claim 1 , wherein the amount of iridium catalyst used is within the range of from 0.001 mol % to 5 mol % claim 1 , based on the amount of the compound of the formula (II).8: The process according to claim 1 , wherein the hydrogenation is conducted at a temperature within the range of from 20° C. to 130° C.9: The process according to claim 1 , wherein the hydrogenation is conducted in presence of a ...

Подробнее
Номер записи: 28
03-02-2022 дата публикации

CATALYST SYSTEM CONTAINING A METATHESIS CATALYST AND AT LEAST ONE PHENOLIC COMPOUND AND A PROCESS FOR METATHESIS OF NITRILE-BUTADIENE RUBBER (NBR) USING THE CATALYST SYSTEM

Номер: US20220032279A1
Автор: KIRSCH Jurgen, KNEBEL Karsten, SCHNEIDERS Karola, WEGE Volker
Принадлежит:

The present invention relates to a catalyst system containing a metathesis catalyst containing at least one N-heterocyclic carbene ligand and at least one phenolic compound and to a process for performing the metathesis on nitrile rubbers for reducing their molecular weight using a metathesis catalyst containing at least one N-heterocyclic carbene ligand (NHC ligand) and at least one phenolic compound. 2. The catalyst system of claim 1 , wherein the metathesis catalyst is selected from the group consisting of:dichloro(fluorenylidene)(1,3-dimesityldihydroimidazolylidene)(triphenylphosphino)ruthenium,1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)bis(3-bromopyridine)ruthenium(II), and,1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)(2-isopropoxy-5-nitrobenzylidene)ruthenium(II)chloride.3. The catalyst system of wherein the phenolic compound of general formula (Z1) is selected from the group consisting of:2,2′-methylene-bis(4-methyl-6-tert-butylphenol),2,6-di-tert-butyl-4-methylphenol, and,2,2′-methylenebis(4-methyl-6-nonylphenol).4. The catalyst system of claim 1 , wherein the molar ratio of metathesis catalyst to phenolic compound of general formula (Z1) or (Z2)=1:(0.01-1000).5. A process of performing a metathesis of nitrile rubber claim 1 , the process comprising the use of the catalyst system of .6. A process of reducing the molecular weight of nitrile rubbers claim 1 , in which nitrile rubber is subjected to a metathesis reaction in the presence of a complex catalyst system of .7. The process of claim 6 , wherein the amount of metathesis catalyst is 1 to 1000 ppm of noble metal claim 6 , based on the employed nitrile rubber.8. The process of claim 6 , wherein the amount of phenolic compound of general formula (Z1) or (Z2) is 0.0001 phr to 5 phr claim 6 , based on the nitrile rubber to be degraded.9. The process of claim 6 , ...

Подробнее
Номер записи: 29
18-01-2018 дата публикации

ETHYLENE TETRAMERIZATION CATALYST SYSTEM AND METHOD FOR PREPARING 1-OCTENE USING THE SAME

Номер: US20180016206A1
Автор: Chae Sung Seok, HAN Taek Kyu, JUNG Jae Ho, KANG Sang Ook, Ok Myung Ahn
Принадлежит:

Disclosed herein is a method of preparing 1-octene at high activity and high selectivity while stably maintaining reaction activity by tetramerizing ethylene using a chromium-based catalyst system comprising a transition metal or a transition metal precursor, a cocatalyst, and a P—C—C—P backbone structure ligand represented by (R)(R)P—(R)CHCH(R)—P(R)(R). 110.-. (canceled)12. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated at a temperature of −20˜250° C.13. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated at a temperature of 15˜130° C.14. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated at a temperature of 30˜70° C.15. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated at a pressure of atmospheric pressure to 500 bar.16. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated at a pressure of 10-70 bar.17. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated at a pressure of 30-50 bar.18. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the method is operated using inactive solvent selected from saturated aliphatic hydrocarbons claim 11 , unsaturated aliphatic hydrocarbons claim 11 , aromatic hydrocarbons claim 11 , halogenated hydrocarbons claim 11 , or a combination thereof.19. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the inactive solvent selected from benzene claim 11 , toluene claim 11 , xylene claim 11 , cumene claim 11 , heptanes claim 11 , cyclohexane claim 11 , methylcyclohexane claim 11 , methylcyclopentane claim 11 , n-hexane claim 11 , 1-hexene or a combination thereof.20. The method of preparing 1-hexene by trimerizing ethylene of claim 11 , wherein the aluminum of alkylaluminoxane: ...

Подробнее
Номер записи: 30
15-01-2015 дата публикации

Catalyst complex with carbene ligand

Номер: US20150018557A1
Автор: Jinkun Huang, Steven P. Nolan
Принадлежит: Materia Inc

Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.

Подробнее
Номер записи: 31
15-01-2015 дата публикации

Chelating Carbene Ligand Precursors and Their Use in the Synthesis of Metathesis Catalysts

Номер: US20150018559A1
Автор: Gindelberger David E., Haar Christopher M., Pederson Richard L., Schrodi Yann, Woertink Jason K.
Принадлежит: MATERIA, INC.

Chelating ligand precursors for the preparation of olefin methathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various methathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene methathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type methathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent. 2. The chelating carbene complex of claim 1 , wherein the chelating carbene complex is prepared by a method comprising contacting a metathesis-active metal carbene complex of the formula XXLLM=CRRwith a beta-substituted styrene ligand precursor claim 1 , wherein{'sup': 1', '2', '1, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'X, X, L, and M are as defined in ;'}{'sup': 2', '1', '2', '1', '2, 'Lis any neutral electron donor, and wherein any of two or three of X, X, L, and Lmay form a multidentate ligand; and'}{'sup': 1', '2', '1', '2, 'Rand Rare each, independently, selected from hydrogen or a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkylcarboxylate, arylcarboxylate, alkoxy, alkenyloxy, alkynyloxy, aryloxy, alkoxycarbonyl, alkylthio, alkylsulfonyl, alkylsulfinyl, or trialkylsilyl, wherein each of the substituents is substituted or ...

Подробнее
Номер записи: 32
17-01-2019 дата публикации

Complexes

Номер: US20190016742A1
Автор: Colacot Thomas John, Johansson Seechum Carin C. C., Parisel Sebastien Laurent
Принадлежит:

The present invention provides a complex of formula (1), 2. The complex of claim 1 , wherein M is palladium.3. The complex of claim 1 , wherein Rand Rare tert-butyl.4. The complex of claim 1 , wherein Rand Rare cyclohexyl.5. The complex of claim 4 , wherein Rand Rare phenyl.6. The complex of claim 1 , wherein Rand Rare linked to form a 4- to 7-membered ring.7. The complex of claim 1 , wherein Ris phenyl claim 1 , 2-dimethylaminophenyl claim 1 , 3-dimethylaminophenyl claim 1 , or 4-dimethylaminophenyl.8. The complex of claim 1 , wherein Ris furanyl claim 1 , thiophenyl claim 1 , pyrrolyl claim 1 , pyridinyl claim 1 , or quinolinyl.9. The complex of claim 1 , wherein X is Cl.10. The complex of claim 1 , wherein each Ris independently methyl claim 1 , phenyl claim 1 , or substituted phenyl.12. A method for performing a carbon-carbon coupling reaction or a carbon-nitrogen coupling reaction in the presence of a catalyst claim 1 , the method comprising using a catalyst that is a complex of .13. A method for performing a carbon-carbon coupling reaction or a carbon-nitrogen coupling reaction in the presence of a catalyst claim 2 , the method comprising using a catalyst that is a complex of . This application is a divisional of U.S. patent application Ser. No. 13/806,575, filed Mar. 11, 2013, which is the National Stage of International Patent Application No. PCT/GB2011/051171, filed Jun. 22, 2011, which claims priority from U.S. Provisional Patent Application No. 61/357,744, filed Jun. 23, 2010, the disclosures of each of which are incorporated herein by reference in their entireties for any and all purposes.The present invention relates to transition metal complexes and, in particular, to π-allyl complexes, such as π-allylpalladium and π-allylnickel complexes. The invention also relates to the use of the transition metal complexes in coupling reactions.In many transitions metal mediated reactions, the active catalyst is formed in situ by the additional of a transition ...

Подробнее
Номер записи: 33
16-01-2020 дата публикации

Cross-Coupling Reaction Catalysts, and Methods of Making and Using Same

Номер: US20200016582A1
Автор: HAZARI Nilay, Melvin Patrick
Принадлежит:

The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention. 2. The precatalyst of claim 1 , wherein each occurrence of M is independently selected from the group consisting of Pd claim 1 , Ni claim 1 , and Pt.3. The precatalyst of claim 1 , wherein at least one applies:(a) the two occurrences of M in (I) are identical;(b) the two ligands comprising 5-membered rings are identical;(c) each occurrence of Z is independently selected from the group consisting of CH and CR.46-. (canceled)7. The precatalyst of claim 1 , wherein each occurrence of X is independently selected from the group consisting of triflate claim 1 , pentafluoroethanesulfonate claim 1 , heptafluoropropanesulfonate claim 1 , and nonafluorobutanesulfonate.8. (canceled)11. The precatalyst of claim 9 , wherein M is selected from the group consisting of Pd claim 9 , Ni claim 9 , and Pt.12. (canceled)13. The precatalyst of claim 9 , wherein each occurrence of Z is independently selected from the group consisting of CH and CR.14. The precatalyst of claim 9 , wherein X is selected from the group consisting of triflate claim 9 , pentafluoroethanesulfonate claim 9 , heptafluoropropanesulfonate claim 9 , and nonafluorobutanesulfonate.15. (canceled)16. The precatalyst of claim 9 ,wherein L is selected from the group consisting of 1,3-bis(2,6-diisopropyl phenyl)-1,3-dihydro-2H-imidazol-2-ylidene and 1,3-bis(2,6-bis-(diphenylmethyl)-4-methoxyphenyl)imidazol-2-ylidene, orwherein L is a bidentate phosphine ligand.17. (canceled)18. The precatalyst of claim 16 , wherein L is a bidentate phosphine ligand selected from the group consisting of AmPhos (di-t-butylphosphino-4-dimethylaminobenzene) claim 16 , DavePhos (2-dicyclohexylphosphino-2′-(N claim 16 ,N- ...

Подробнее
Номер записи: 34
21-01-2021 дата публикации

INTEGRATED CAPTURE AND CONVERSION OF CO2 TO METHANOL OR METHANOL AND GLYCOL

Номер: US20210017108A1
Автор: Dagle Robert A., Heldebrant David J., Jiang Yuan, Kothandaraman Jotheeswari
Принадлежит: BATTELLE MEMORIAL INSTITUTE

A process for producing methanol includes combining a hydrogenation catalyst, hydrogen, and COwith a condensed phase solution comprising an amine under conditions effective to form methanol and water. A process for coproduction of methanol and a glycol includes combining an epoxide, a hydrogenation catalyst, hydrogen, and COwith a condensed phase solution comprising an amine under conditions effective to form methanol and a glycol. 1. A process , comprising:{'sub': 2', '2, 'producing methanol and a glycol by combining an epoxide, a hydrogenation catalyst, hydrogen, and COwith a condensed phase comprising an amine under conditions effective to provide a reaction between the epoxide, hydrogen, and COto form methanol and the glycol, wherein at least 10 mol % of the epoxide is consumed in the reaction.'}2. The process of claim 1 , wherein the condensed phase is a condensed phase solution further comprising the CO.3. The process of claim 2 , further comprising preparing the condensed phase solution by contacting a gas stream comprising COwith an amine-containing solvent or solution prior to combining the epoxide claim 2 , the hydrogenation catalyst claim 2 , and the hydrogen with the condensed phase solution.4. The process of claim 3 , wherein contacting the gas stream with the amine-containing solvent or solution is performed:(i) at a temperature T′ within a range of from 20° C. to 60° C.; or(ii) at an initial pressure P′ within a range of from 0.1 MPa to 5 MPa; or(iii) both (i) and (ii).5. The process of claim 1 , wherein the conditions effective to form methanol and the glycol comprise:{'sub': 'MG', '(i) a temperature Twithin a range of from 50° C. to 170° C.; or'}{'sub': 'MG', '(ii) an initial pressure Pwithin a range of from 3 MPa to 10 MPa; or'}{'sub': 'MG', '(iii) a time twithin a range of from 3 seconds to 36 hours; or'}(iv) any combination of (i), (ii), and (iii).6. The process of claim 1 , further comprising:{'sub': '2', '(i) combining the epoxide, the CO, and ...

Подробнее
Номер записи: 35
28-01-2016 дата публикации

Metallorganocatalysis For Asymmetric Transformations

Номер: US20160023198A1
Автор: Xumu Zhang
Принадлежит: Rutgars State University Of New Jersey

A ligand having the structure or its enantiomer; (I) wherein: each one of R a , R b , R c and R d is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH 2 NH; *CH(CH 3 )NH(C*,R); and the organocatalyst is an organic molecule catalyst covalently bound to the bridge group. Also, a catalyst having the structure or its enantiomer: (II) wherein: each one of R a , R b , R c and R d is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH 2 NH; *CH(CH 3 )NH(C*,R); and *CH(CH 3 )NH(C*,S); the organocatalyst is an organic molecule catalyst covalently bound to the bridge group; and M is selected from the group consisting of Rh, Pd, Cu, Ru, Ir, Ag, Au, Zn, Ni, Co, and Fe.

Подробнее
Номер записи: 36
28-01-2016 дата публикации

P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS

Номер: US20160023199A1
Автор: BAYARDON Jerome, COLOBERT Francoise, HENRY Jean-Christophe, JUGE Sylvain, LAUREANO Hugo, LEROUX Frederic, REMOND Emmanuelle
Принадлежит:

Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). 2. The process according to claim 1 , wherein the electrophile is selected from the group consisting of boronate reagents claim 1 , aldehydes claim 1 , ketones claim 1 , acyl chlorides claim 1 , halosilanes claim 1 , haloalkanes claim 1 , and Michael acceptors such as α claim 1 ,β-insaturated ester claim 1 , α claim 1 ,β-insaturated ketones claim 1 , and α claim 1 ,β-insaturated phosphine derivatives.3. The process according to claim 1 , wherein the oxidative reagent is selected from the group consisting of transition metal salts and transition metal complexes claim 1 , wherein the metal is selected from the group comprising iron claim 1 , copper.4. The process according to claim 1 , wherein compound (VII) is chiral. The present invention relates to novel P-chirogenic organophosphorus compounds of general formula (I). The present invention also provides a process for the synthesis of said compounds of formula (I). The present invention also relates to intermediate products of general formulae (II), (III) and (IV), as shown below, which are involved in the synthesis of compounds (I).Compounds of general formula (I) may useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Further, the invention relates to metal complexes comprising compounds (I) as ligands. The novel compounds and complexes of the present invention are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation.During the past decades, asymmetric organocatalysis and organometallic catalysis made a breakthrough and became methodologies of choice for the synthesis of chiral substances on laboratory as well as on industrial ...

Подробнее
Номер записи: 37
26-01-2017 дата публикации

BENZENE-BASED DIPHOSPHINE LIGANDS FOR ALKOXYCARBONYLATION

Номер: US20170022137A1
Автор: Beller Matthias, DONG Kaiwu, DYBALLA Katrin Marie, Franke Robert, Fridag Dirk, GEILEN Frank, HESS Dieter, Jackstell Ralf, NEUMANN Helfried
Принадлежит: EVONIK DEGUSSA GmbH

The invention relates to compounds of formula (I) 3. Compound according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 3', '20, 'where at least two of the R, R, R, Rradicals are a —(C-C)-heteroaryl radical.'}4. Compound according to claim 1 ,{'sup': 1', '3, 'sub': 3', '20, 'where the Rand Rradicals are each a —(C-C)-heteroaryl radical.'}5. Compound according to claim 1 ,{'sup': 1', '3, 'sub': 3', '20, 'where the Rand Rradicals are each a —(C-C)-heteroaryl radical;'}{'sup': 2', '4, 'sub': 1', '12', '3', '12', '3', '12', '6', '20, 'and Rand Rare each independently selected from —(C-C)-alkyl, —(C-C)-cycloalkyl, —(C-C)-heterocycloalkyl, —(C-C)-aryl.'}6. Compound according to claim 1 ,{'sup': 1', '3, 'sub': 3', '20, 'where the Rand Rradicals are each a —(C-C)-heteroaryl radical;'}{'sup': 2', '4, 'sub': 1', '12, 'and Rand Rare each independently selected from —(C-C)-alkyl.'}7. Compound according to claim 1 ,{'sup': 1', '2', '3', '4, 'where R, R, R, R, if they are a heteroaryl radical, are each independently selected from furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, furazanyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, benzofuranyl, indolyl, isoindolyl, benzimidazolyl, quinolyl, isoquinolyl.'}9. Complex comprising Pd and a compound according to .11. Process according to claim 10 ,wherein the ethylenically unsaturated compound comprises 2 to 30 carbon atoms and optionally one or more functional groups selected from carboxyl, thiocarboxyl, sulpho, sulphinyl, carboxylic anhydride, imide, carboxylic ester, sulphonic ester, carbamoyl, sulphamoyl, cyano, carbonyl, carbonothioyl, hydroxyl, sulphhydryl, amino, ether, thioether, aryl, heteroaryl or silyl groups and/or halogen substituents.12. Process according to claim 10 ,wherein the ethylenically unsaturated compound is selected from ethene, propene, 1-butene, cis- and/or trans-2-butene, isobutene, 1,3-butadiene, 1-pentene, cis- and/or trans-2-pentene, 2-methyl-1- ...

Подробнее
Номер записи: 38
26-01-2017 дата публикации

Butyl-bridged diphosphine ligands for alkoxycarbonylation

Номер: US20170022138A1
Автор: Dieter Hess, Dirk Fridag, Frank Geilen, Helfried Neumann, Kaiwu DONG, Katrin Marie Dyballa, Matthias Beller, Ralf Jackstell, Robert Franke, Xiangjie FANG
Принадлежит: EVONIK DEGUSSA GmbH

The invention relates to compounds of formula (I) where R 1 , R 2 , R 3 , R 4 are each independently selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl, —(C 3 -C 20 )-heteroaryl; at least one of the R 1 , R 2 , R 3 , R 4 radicals is a —(C 3 -C 20 )-heteroaryl radical; and R 1 , R 2 , R 3 , R 4 , if they are —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl or —(C 3 -C 20 )-heteroaryl, may each independently be substituted by one or more substituents selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —O—(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl-(C 6 -C 20 )-aryl, —O—(C 3 -C 12 )-cycloalkyl, —S—(C 1 -C 12 )-alkyl, —S—(C 3 -C 12 )-cycloalkyl, —COO—(C 1 -C 12 )-alkyl, —COO—(C 3 -C 12 )-cycloalkyl, —CONH—(C 1 -C 12 )-alkyl, —CONH—(C 3 -C 12 )-cycloalkyl, —CO—(C 1 -C 12 )-alkyl, —CO—(C 3 -C 12 )-cycloalkyl, —N—[(C 1 -C 12 )-alkyl] 2 , —(C 6 -C 20 )-aryl, —(C 6 -C 20 )-aryl-(C 1 -C 12 )-alkyl, —(C 6 -C 20 )-aryl-O—(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl, —(C 3 -C 20 )-heteroaryl-(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl-O-(C 1 -C 12 )-alkyl, —COOH, —OH, —SO 3 H, —NH 2 , halogen; and to the use thereof as ligands in alkoxycarbonylation.

Подробнее
Номер записи: 39
26-01-2017 дата публикации

MONOPHOSPHINE COMPOUNDS AND PALLADIUM CATALYSTS BASED THEREON FOR THE ALKOXYCARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS

Номер: US20170022139A1
Автор: Beller Matthias, DONG Kaiwu, DYBALLA Katrin Marie, Franke Robert, Fridag Dirk, GEILEN Frank, HESS Dieter, Jackstell Ralf
Принадлежит: EVONIK DEGUSSA GmbH

The invention relates to compounds of formula (I) 2. Compound according to claim 1 ,{'sup': '1', 'sub': 1', '12, 'where Ris —(C-C)-alkyl.'}3. Compound according to claim 1 ,{'sup': '2', 'sub': 6', '20', '3', '20, 'where Ris selected from —(C-C)-aryl and —(C-C)-heteroaryl.'}4. Compound according to claim 1 ,{'sup': '2', 'where Ris selected from phenyl, pyrimidyl and imidazolyl.'}5. Compound according to claim 1 ,{'sup': '3', 'where Ris selected from heteroaryl groups having five or six ring atoms.'}6. Compound according to claim 1 ,{'sup': '3', 'where Ris selected from pyrimidyl and imidazolyl.'}7. Compound according to claim 1 ,{'sup': 1', '2', '3, 'sub': 1', '12, 'where R, Rand Rmay each independently be substituted by one or more substituents selected from —(C-C)-alkyl.'}9. Complex comprising Pd and a compound according to .11. Process according to claim 10 , wherein the ethylenically unsaturated compound is selected from ethene claim 10 , propene claim 10 , 1-butene claim 10 , cis- and/or trans-2-butene claim 10 , isobutene claim 10 , 1 claim 10 ,3-butadiene claim 10 , 1-pentene claim 10 , cis- and/or trans-2-pentene claim 10 , 2-methyl-1-butene claim 10 , 3-methyl-1-butene claim 10 , 2-methyl-2-butene claim 10 , hexene claim 10 , tetramethylethylene claim 10 , heptene claim 10 , 1-octene claim 10 , 2-octene claim 10 , di-n-butene claim 10 , and mixtures thereof.12. Process according to claim 10 ,wherein the compound comprising Pd in process step b) is selected from palladium dichloride, palladium(II) acetylacetonate, palladium(II) acetate, dichloro(1,5-cycloocta-diene)palladium(II), bis(dibenzylideneacetone)palladium, bis(acetonitrile)dichloro-palladium(II), palladium(cinnamyl) dichloride.13. Process according to claim 10 ,wherein the alcohol in process step c) is selected from methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, 2-propanol, tert-butanol, 3-pentanol, cyclohexanol, phenol, and mixtures thereof.14. Process according to claim 10 , ...

Подробнее
Номер записи: 40
26-01-2017 дата публикации

Catalysts for (e)-selective olefin metathesis

Номер: US20170022231A1
Автор: Choon Woo Lee, Pablo E. GUZMAN, Robert H. Grubbs, T. Patrick MONTGOMERY, Tonia S. AHMED
Принадлежит: California Institute of Technology CalTech

This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

Подробнее
Номер записи: 41
26-01-2017 дата публикации

METHOD FOR IN-SITU FORMATION OF METATHESIS CATALYSTS

Номер: US20170022232A1
Автор: Schrodi Yann
Принадлежит:

Synthetic methods for the in-situ formation of olefin metathesis catalysts are disclosed, as well as the use of such catalysts in metathesis reactions of olefins and olefin compounds. In one aspect, a method is provided for synthesizing an organometallic compound of the formula 2. The compound of claim 1 , wherein M is Ru or Os.3. The compound of claim 1 , wherein L claim 1 , L claim 1 , and Lare independently selected from phosphine claim 1 , sulfonated phosphine claim 1 , phosphite claim 1 , phosphinite claim 1 , phosphonite claim 1 , arsine claim 1 , stibine claim 1 , ether claim 1 , amine claim 1 , amide claim 1 , imine claim 1 , sulfoxide claim 1 , carboxyl claim 1 , nitrosyl claim 1 , pyridine claim 1 , substituted pyridine claim 1 , imidazole claim 1 , substituted imidazole claim 1 , pyrazine claim 1 , thioether claim 1 , and thiocarbonyl.4. The compound of claim 3 , wherein the phosphine is of the formula PRRR claim 3 , wherein R claim 3 , R claim 3 , and Rare each independently selected from aryl claim 3 , substituted aryl claim 3 , alkyl claim 3 , substituted alkyl claim 3 , cycloalkyl claim 3 , substituted cycloalkyl claim 3 , heterocycles claim 3 , and substituted heterocycles.5. The compound of claim 1 , wherein Xand Xare independently selected from hydrogen claim 1 , halide claim 1 , C-Calkyl claim 1 , C-Caryl claim 1 , C-Calkoxy claim 1 , C-Caryloxy claim 1 , C-Calkoxycarbonyl claim 1 , C-Caryloxycarbonyl claim 1 , C-Cacyl claim 1 , C-Cacyloxy claim 1 , C-Calkylsulfonato claim 1 , C-Carylsulfonato claim 1 , C-Calkylsulfanyl claim 1 , C-Carylsulfanyl claim 1 , C-Calkylsulfinyl claim 1 , or C-Carylsulfinyl claim 1 , any of which claim 1 , with the exception of hydrogen and halide claim 1 , are optionally further substituted with one or more groups selected from halide claim 1 , C-Calkyl claim 1 , C-Calkoxy claim 1 , and C-Caryl.9. A method of performing an olefin metathesis reaction claim 1 , comprising contacting the compound of with an olefin.10. The ...

Подробнее
Номер записи: 42
26-01-2017 дата публикации

PHOSPHINE LIGAND AND PALLADIUM CATALYSTS BASED THEREON FOR THE ALKOXYCARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS

Номер: US20170022234A1
Автор: Beller Matthias, DONG Kaiwu, DYBALLA Katrin Marie, FANG Xiangjie, Franke Robert, Fridag Dirk, GEILEN Frank, GÜLAK Samet, HESS Dieter, Jackstell Ralf, Jennerjahn Reiko, NEUMANN Helfried
Принадлежит: EVONIK DEGUSSA GmbH

The invention relates to a compound of formula (1) 2. Complex comprising Pd and a compound according to .4. Process according to claim 3 , wherein the ethylenically unsaturated compound is selected from ethene claim 3 , propene claim 3 , 1-butene claim 3 , cis- and/or trans-2-butene claim 3 , isobutene claim 3 , 1 claim 3 ,3-butadiene claim 3 , 1-pentene claim 3 , cis- and/or trans-2-pentene claim 3 , 2-methyl-1-butene claim 3 , 3-methyl-1-butene claim 3 , 2-methyl-2-butene claim 3 , hexene claim 3 , tetramethylethylene claim 3 , heptene claim 3 , 1-octene claim 3 , 2-octene claim 3 , di-n-butene claim 3 , or mixtures thereof.5. Process according to claim 3 , wherein the ethylenically unsaturated compound comprises 8 to 22 carbon atoms.6. Process according to claim 3 , wherein the compound comprising Pd in process step b) is selected from palladium dichloride claim 3 , palladium(II) acetylacetonate claim 3 , palladium(II) acetate claim 3 , dichloro(1 claim 3 ,5-cyclooctadiene)palladium(II) claim 3 , bis(dibenzylideneacetone)palladium claim 3 , bis(acetonitrile)dichloropalladium(II) claim 3 , palladium(cinnamyl) dichloride.7. Process according to claim 3 , wherein the alcohol in process step c) is selected from methanol claim 3 , ethanol claim 3 , 1-propanol claim 3 , 1-butanol claim 3 , 1-pentanol claim 3 , 1-hexanol claim 3 , 2-propanol claim 3 , tert-butanol claim 3 , 3-pentanol claim 3 , cyclohexanol claim 3 , phenol claim 3 , or mixtures thereof. The present invention relates to an improved phosphine ligand and to the use thereof in alkoxycarbonylation.The alkoxycarbonylation of ethylenically unsaturated compounds is a process of increasing significance. An alkoxycarbonylation is understood to mean the reaction of ethylenically unsaturated compounds such as olefins with carbon monoxide and alcohols in the presence of a metal or a metal complex and a ligand to give the corresponding esters:Among the alkoxycarbonylation reactions, ethene methoxycarbonylation to ...

Подробнее
Номер записи: 43
26-01-2017 дата публикации

FERROCENE-BASED COMPOUNDS AND PALLADIUM CATALYSTS BASED THEREON FOR THE ALKOXYCARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS

Номер: US20170022235A1
Автор: Beller Matthias, DONG Kaiwu, DYBALLA Katrin Marie, Franke Robert, Fridag Dirk, GEILEN Frank, HESS Dieter, Jackstell Ralf, NEUMANN Helfried
Принадлежит: EVONIK DEGUSSA GmbH

The invention relates to a compound of formula (I) 2. Compound according to claim 1 ,{'sup': 1', '3, 'where Rand Rare each independently selected from furyl, thienyl, 2-pyrrolyl, 4-imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, furazanyl, tetrazolyl.'}3. Compound according to claim 1 ,{'sup': 1', '3, 'where Rand Rare each independently selected from furyl and thienyl.'}4. Compound according to claim 1 ,{'sup': 2', '4, 'sub': 1', '12', '3', '12', '6', '20, 'where Rand Rare each independently selected from —(C-C)-alkyl, —(C-C)-cycloalkyl and —(C-C)-aryl.'}5. Compound according to claim 1 ,{'sup': 2', '4, 'sub': 1', '12, 'where Rand Rare each —(C-C)-alkyl.'}6. Compound according to claim 1 ,{'sup': 1', '3, 'where Rand Rmay each independently be substituted by one or more substituents selected from'}{'sub': 1', '12', '3', '12', '1', '12', '1', '12', '6', '20', '3', '12', '6', '20', '6', '20', '1', '12', '6', '20', '1', '12, '—(C-C)-alkyl, —(C-C)-cycloalkyl, —O—(C-C)-alkyl, —O—(C-C)-alkyl-(C-C)-aryl, —O—(C-C)-cycloalkyl, —(C-C)-aryl, —(C-C)-aryl-(C-C)-alkyl, —(C-C)-aryl-O—(C-C)-alkyl.'}7. Compound according to claim 1 ,{'sup': 3', '4, 'sub': 1', '12', '3', '12', '3', '12', '6', '20, 'where Rand R, if they are —(C-C)-alkyl, —(C-C)-cycloalkyl, —(C-C)-heterocycloalkyl or —(C-C)-aryl,'}{'sub': 1', '12', '3', '12', '1', '12', '1', '12', '6', '20', '3', '12', '6', '20', '6', '20', '1', '12', '6', '20', '1', '12, 'may each independently be substituted by one or more substituents selected from —(C-C)-alkyl, —(C-C)-cycloalkyl, —O—(C-C)-alkyl, —O—(C-C)-alkyl-(C-C)-aryl, —O—(C-C)-cycloalkyl, —(C-C)-aryl, —(C-C)-aryl-(C-C)-alkyl, —(C-C)-aryl-O—(C-C)-alkyl.'}10. Complex comprising Pd and a compound according to .12. Process according to claim 11 ,wherein the ethylenically unsaturated compound is selected from ethene, propene, 1-butene, cis- and/or trans-2-butene, isobutene, 1,3-butadiene, 1-pentene, cis- and/or trans-2-pentene, 2-methyl-1-butene, 3-methyl-1- ...

Подробнее
Номер записи: 44
10-02-2022 дата публикации

Method for Preparation of Fluoro Alkylated Compounds by Homogeneous NI Catalysis

Номер: US20220041530A1
Автор: Beller Matthias, Ellinger Stefan, FISCHER Florian, NEUMANN Helfried, Rotta-Loria Nicolas, Taeschler Christoph, Zaragoza Doerwald Florencio, Zhang Shaoke
Принадлежит:

The invention discloses a method for the preparation of fluoro alkylated compounds by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides in the presence of a base. 2. The method according to claim 1 , wherein{'sub': '3', 'LIG is compound of formula (DPEPhos) or PhP.'}3. The method according to claim 1 , wherein{'sub': 2', '3', '3', '4, 'BAS is selected from the group consisting of CsCO, KPO, NaH and NaOtBu.'}5. The method according to claim 1 , wherein by 1, 2 or 3 in case of COMPSUBST-I being a monocyclic compound with 5 endocyclic atoms,', 'by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a monocyclic compound with 6 endocyclic atoms,', 'by 1, 2, 3 or 4 in case of COMPSUBST-I being a bicyclic compound wherein a 5-membered and a 6-membered ring are ortho-fused,', 'by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a bicyclic compound wherein two 6-membered rings are ortho-fused,, 'COMPSUBST-I is unsubstituted or substituted'}{'sub': 1-4', '3', '2', 'm', '2, 'identical or different substituents independently from each other selected from the group consisting of Calkyl, CM alkoxy, OH, C(H)═O, N(R10)R11, CN, F, Cl, Br, CF, (CH)—C(O)Y1, and S(O)R50;'}{'sub': '1-4', 'said Calkyl substituent of COMPSUBST-I is unsubstituted or substituted with 1, 2 or 3 identical or different substituents selected from the group consisting of halogen;'}{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'with R10, R11, m, Y1, R50 and halogen as defined in .'}7. The method according to claim 1 , wherein{'sub': 1-20', '2', 'n3', '2, 'FAHALIDE is selected from the group consisting of perfluoro Calkyl-X1, Br—(CF)—Br, and FHC—X1;'}with n3 being an integer of 2 to 10.8. The method according to claim 1 , whereinn3 is 2, 3, 4, 5, 6.9. The method according to claim 1 , wherein{'sub': 21', '10', '21', '10', '17', '8', '17', '8', '13', '6', '13', '6', '9', '4', '9', '4', '7', '3', '7', '3', '3', '3', '2', '4', '2', '2, 'FAHALIDE is selected from the group consisting of FC—I, FC—Br, FC—I, ...

Подробнее
Номер записи: 45
10-02-2022 дата публикации

Chiral synthesis of fused bicyclic raf inhibitors

Номер: US20220041595A1
Автор: Andrew BELFIELD, Chiara COLLETTO, Clifford David Jones, Jean-François MARGATHE, Neil HAWKINS, Steven Christopher GLOSSOP
Принадлежит: Jazz Pharmaceuticals Ireland Ltd

The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitor enantiomers of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, with high enantiomeric excess (% ee). The disclosure also relates to method of using the compound of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

Подробнее
Номер записи: 46
01-02-2018 дата публикации

PALLADIUM CATALYSTS WITH IMPROVED PERFORMANCE IN BIOLOGICAL ENVIRONMENTS

Номер: US20180029028A1
Автор: Kirkland Thomas, Levin Sergiy, Ohana Rachel Friedman, Wood Keith
Принадлежит:

Provided herein are palladium (Pd) catalysts with improved performance in biological environments. In particular, formulations, methods of preparations, and storage conditions are provided that provide improved performance of Pd catalysts under protein-rich conditions. 1. A Pd catalyst composition comprising phosphine-coordinated palladium ions , wherein phosphine ligand is present at 6-12 fold excess over palladium in the composition.2. The Pd catalyst composition of claim 1 , wherein the phosphine ligand is a strong π-acceptor aryl phosphine.3. (canceled)4. The Pd catalyst composition of claim 3 , wherein the phosphine ligand is selected from the group consisting of DANPHOS claim 3 , o-DANPHOS claim 3 , p-DANPHOS claim 3 , DAN2PHOS claim 3 , o-DAN2PHOS p-DAN2PHOS claim 3 , and DANPHOS/DAN2PHOS derivatives with alternative solubilizing groups.5. The Pd catalyst composition of claim 4 , wherein the phosphine ligand is o-DANPHOS.6. The Pd catalyst composition of claim 1 , wherein the palladium is provided as a Palladium(II) salt selected from the group consisting of: Palladium acetate (Pd(OAc)) claim 1 , Palladium trifluoroacetate (Pd(TFA)) claim 1 , Palladium nitrate (Pd(NO)) claim 1 , Palladium chloride (PdCl) claim 1 , Palladium bromide (PdBr) claim 1 , Sodium tetrachloropalladate (NaPdCl) claim 1 , Potassium tetrachloropalladate (KPdCl) claim 1 , Lithium tetrachloropalladate (LiPdCl) claim 1 , Sodium tetrabromopalladate (NaPdBr) claim 1 , Potassium tetrabromopalladate (KPdBr) claim 1 , Pd(dibenzylideneacetone) claim 1 , Pd(dibenzylideneacetone) claim 1 , and Buchwald precatalysts.7. The Pd catalyst composition of claim 1 , wherein the phosphine-coordinated palladium ions are in aqueous solution.8. The Pd catalyst composition of claim 1 , wherein the phosphine-coordinated palladium ions are lyophilized.910.-. (canceled)11. A method for the preparation of a Pd catalyst claim 1 , comprising combining a palladium(II) salt with a phosphine ligand in buffered or un- ...

Подробнее
Номер записи: 47
01-02-2018 дата публикации

METHOD FOR PREPARING FORMAMIDE COMPOUND

Номер: US20180030009A1
Автор: Ding Kuiling, Han Zhaobin, Wang Zheng, ZHANG LEI, ZHAO Xiaoyu
Принадлежит: SHANGHAI GREENCARBON HI-TECH CO., LTD.

Disclosed is a method for preparing a formamide compound, the method uses carbon dioxide, hydrogen and an amine compound as raw materials and a transition metal complex as a catalyst, and the reaction is carried out in an organic solvent or in the absence of a solvent to form a formamide compound. The method of the present invention is an effective method of chemical utilization of carbon dioxide, which has the advantages of high reaction efficiency, a good selectivity, mild conditions, economic and environmental protection, being simple and convenient to operate and the like, and has a good popularization and application prospect. 114-. (canceled)17. The method of claim 15 , wherein the molar ratio of the organoamine compound to the catalyst is 1000-5600000:1.18. The method of claim 15 , wherein the molar ratio of the organoamine compound to the catalyst is 10000-4000000:1.19. The method of claim 15 , wherein claim 15 , in step a) claim 15 , a base additive is further used claim 15 , wherein the base additive is selected from a group consisting of alkali metal salts of alcohols claim 15 , alkali metal carbonates claim 15 , alkali metal hydroxides claim 15 , or combinations thereof.20. The method of claim 17 , wherein the molar ratio of the base additive to the catalyst is 1-100:1.21. The method of claim 17 , wherein the molar ratio of the base additive to the catalyst is 1-20:122. The method of claim 17 , wherein the molar ratio of the base additive to the catalyst is 1-5:1.23. The method of claim 15 , wherein the reaction time of the method is 0.1-1000 hours.24. The method of claim 15 , wherein claim 15 , in the method claim 15 , the pressure of hydrogen is 1-100 atmosphere claim 15 , and/or the pressure of carbon dioxide is 1-100 atmospheres.25. The method of claim 15 , wherein the reaction is carried out at 60-200° C.26. The method of claim 15 , wherein the reaction is carried out in an organic solvent; wherein the organic solvent is selected from a group ...

Подробнее
Номер записи: 48
17-02-2022 дата публикации

METHODS FOR RECOVERING AND REUSING SELECTIVE HOMOGENEOUS HYDROGENATION CATALYST

Номер: US20220048017A1
Автор: Jang Namjin, Kim Youngjin, SONG Kyuho
Принадлежит:

The present invention pertains to a method for recovering a selective homogeneous hydrogenation catalyst and a method for reusing the recovered selective homogeneous hydrogenation catalyst. The method for recovering a selective homogeneous hydrogenation catalyst comprises: a step for synthesizing cyclododecene by selectively hydrogenating a first reaction solution containing cyclododecatriene, triphenylphosphine, formaldehyde, and ruthenium chloride, wherein a selective homogeneous hydrogenation catalyst is prepared during the selective hydrogenation reaction from the triphenylphosphine, formaldehyde, and ruthenium chloride to synthesize the cyclododecene; and a step for distilling and separating unreacted cyclododecatriene and cyclododecadiene, as well as the product cyclododecene, from a second reaction solution in which the cyclododecene synthesis has been completed, and recovering the selective homogeneous hydrogenation catalyst. 1. A method for recovering a selective homogeneous hydrogenation catalyst , comprising:a step of synthesizing cyclododecene by selectively hydrogenating a first reaction solution containing cyclododecatriene, triphenylphosphine, formaldehyde, and ruthenium chloride, the cyclododecene being synthesized by preparation of a selective homogeneous hydrogenation catalyst from the triphenylphosphine, the formaldehyde, and the ruthenium chloride during the selective hydrogenation; anda step of distilling and separating unreacted cyclododecatriene and cyclododecadiene, and the cyclododecene that is a product from a second reaction solution in which the cyclododecene synthesis is completed, and recovering the selective homogeneous hydrogenation catalyst.2. The method of claim 1 , wherein the distillation and separation is performed at a temperature of 100 to 200° C. and a pressure of 0.5 bar or less.3. The method of claim 1 , wherein the recovering of the selective homogeneous hydrogenation catalyst is performed at a temperature of 10 to 30° C. ...

Подробнее
Номер записи: 49
17-02-2022 дата публикации

HIGHLY EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN VIA RHODIUM CATALYZED ASYMMETRIC HYDROGENATION

Номер: US20220048917A1
Автор: CHIKKALI Samir Hujur, Khopade Kishor Vilas
Принадлежит:

The present invention provides highly efficient process for the preparation of enantiomerically enriched Sitagliptin of Formula (Ia). More particularly, a direct rhodium catalyzed asymmetric hydrogenation in the presence of bis-phosphine chiral ligand has been developed to yield enantiopure Sitagliptin product with the highest enantiomeric excess of 85-99.9%. 14-. (canceled)6. The process of claim 5 , wherein the rhodium catalyst is [Rh(COD)OTf].7. The process of claim 6 , wherein the additive is selected from the group consisting of salicylic acid claim 6 , acetic acid claim 6 , ammonium chloride claim 6 , phosphoric acid claim 6 , ammonium salicylate claim 6 , tetramethyl ammonium iodide claim 6 , tetraethyl ammonium iodide claim 6 , tetra butyl ammonium bromide claim 6 , butyl phosphoric acid claim 6 , dibutyl phosphate claim 6 , and tributyl phosphate.8. The process of claim 6 , wherein the solvent is selected from the group consisting of methanol claim 6 , dichloromethane claim 6 , tetrahydrofuran claim 6 , trifluoroethanol claim 6 , toluene claim 6 , 1 claim 6 ,4-dioxane claim 6 , and ethyl acetate. This application is a national-stage application under 35 U.S.C. § 371 of International Application No. PCT/IN2019/050896, filed Dec. 9, 2019, which International Application claims benefit of priority to Indian Application No. 201811046767, filed Dec. 11, 2018.The present disclosure provides highly efficient process for the preparation of enantiomerically enriched Sitagliptin. More particularly, a direct rhodium catalyzed asymmetric hydrogenation in the presence of bis-phosphine chiral ligand has been developed to yield enantiopure Sitagliptin product with the highest enantiomeric excess of 85-99.9%.Beta amino acids and its derivatives have lot of medicinal significance. Beta amino acids are also present in peptides and different heterocycles. In beta amino acids, the amino group is linked to the beta carbon. Different free forms and derivatives of beta amino acid ...

Подробнее
Номер записи: 50
01-02-2018 дата публикации

COLORIMETRIC DETERMINATION OF AQUEOUS NITRATE CONCENTRATION

Номер: US20180031535A1
Автор: MacFarland Darren Kent, Young Brendan Easley
Принадлежит:

A method of measuring nitrate concentration in an aqueous sample include mixing the aqueous sample with a water-soluble thioether compound including a chromophore group in the presence of a water soluble catalyst; measuring a color change, and correlating the color change to nitrate concentration. 1. A method of measuring nitrate concentration in an aqueous sample , comprising:a. mixing the aqueous sample with a water-soluble thioether compound including a chromophore group in the presence of a water soluble catalyst,b. measuring a color change, andc. correlating the color change to nitrate concentration.2. The method of wherein the water-soluble thioether compound is chosen to oxidize in the presence of nitrate.3. The method of wherein the water-soluble thioether compound has the formula:{'br': None, 'sup': 3', '2, 'R—S—R,'}{'sup': 3', '2, 'sub': 1', '6, 'wherein Ris a hydrophilic chromophore group and Ris a C-Calkyl group or a polyalkyleneoxide group.'}4. The method of wherein the hydrophilic chromophore group comprises a residue of a water-soluble conjugated chromophore.5. The method of wherein the hydrophilic chromophore group comprises a residue of a water-soluble claim 3 , substituted aromatic chromophore.6. The method of wherein the hydrophilic chromophore is selected from the group consisting of a hydrophilic diarylmethane chromophore claim 3 , a hydrophilic triarylmethane chromophore claim 3 , a hydrophilic xanthene chromophore claim 3 , a hydrophilic boron-dipyrromethene chromophore and a hydrophilic pyrene chromophore.7. The method of wherein the polyalkyleneoxide comprises 4 to 5000 carbon atoms.8. The method of wherein the water soluble catalyst comprises MoOCl(L)wherein L is a hydrophilic group.9. The method of wherein L comprises a water soluble phosphine.10. The method of wherein L is trisulfonated-triphenylphosphineoxide.11. The method of wherein the water soluble catalyst further comprises a Cu co-catalyst.12. The method of wherein the color change ...

Подробнее
Номер записи: 51
31-01-2019 дата публикации

Method for Producing Alpha, Alpha-Difluoroacetaldehyde

Номер: US20190031587A1
Автор: Asami INAZU, Eri NISHIZAWA, Ryo Nadano, Shinya Akiba
Принадлежит: Central Glass Co Ltd

Disclosed is an industrial method for efficient production of an α,α-difluoroaldehyde compound, which includes reaction of an α,α-difluoroacetate with hydrogen gas (H2) in the presence of a ruthenium catalyst and a base. By the adoption of specific reaction conditions (catalyst, base, pressure etc.), it is possible to produce the target α,α-difluoroaldehyde compound with a high conversion rate and high selectivity.

Подробнее
Номер записи: 52
31-01-2019 дата публикации

PROCESS FOR THE CATALYTIC REVERSIBLE ALKENE-NITRILE INTERCONVERSION

Номер: US20190031602A1
Автор: FANG Xianjie, MORANDI BILL, Peng Yu
Принадлежит: STUDIENGESELLSCHAFT KOHLE MBH

The present invention refers to processes for catalytic reversible alkene-nitrile interconversion through controllable HCN-free transfer hydrocyanation. 2. Process according to claim 1 , wherein R claim 1 , R claim 1 , Rand Rcan be the same or different and each independently represents H claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl claim 1 , each being optionally substituted by one or more groups selected from straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent claim 1 , or a heterosubstituent claim 1 , or Rand Rform a bond; wherein at least one of R claim 1 , R claim 1 , Rand Ris not hydrogen.3. Process according to claim 1 , wherein R claim 1 , R claim 1 , Rand Rcan be the same or different and each independently represents H claim 1 , straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , each being optionally substituted by one or more groups selected from straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent claim 1 , or a heterosubstituent claim 1 , or at least two of R claim 1 , R claim 1 , Rand Rmay each form a cyclic 3 to 20 membered hydrocarbon ring structure which may further be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , aryl claim 1 , heteroaryl or heterosubstituent claim 1 , and optionally having any of O claim 1 , S claim 1 , N in the straight chain claim 1 , branched chain or cyclic structure claim 1 , wherein optionally at least one of R claim 1 , R claim 1 , Rand Ris not hydrogen.4. Process according to claim 3 , wherein R claim 3 , R claim 3 , Rand Rcan be the same or ...

Подробнее
Номер записи: 53
09-02-2017 дата публикации

Process for the separation and purification of a mixed diol stream

Номер: US20170036976A9
Автор: Scott Donald Barnicki
Принадлежит: Eastman Chemical Co

Disclosed is a process for the purification of a mixed diol stream. The mixed diol stream comprising two-, three-, and four-carbon diols is separated into component diols by extraction with a hydrophobic solvent mixture. The diols recovered in the extractant may be removed from the extractant stream by back extraction with water or by distillation with an azeotrope-forming agent present, preferably an azeotroping agent already present in the extractant mixture.

Подробнее
Номер записи: 54
24-02-2022 дата публикации

PHARMACEUTICAL PROCESS AND INTERMEDIATES

Номер: US20220056027A1
Автор: COOPER Katie Grace, DAVE David Pranay, Graham Mark Andrew, INGLESBY Phillip Anthony, Jackson Lucinda Victoria, Noonan Gary Michael
Принадлежит:

The present disclosure concerns the large-scale manufacture of pharmaceutical compounds, and novel intermediates for use in the manufacture. International Patent Application WO2011154737 discloses morpholine pyrimidines useful for treating cancer, processes for their preparation and pharmaceutical compositions thereof. In particular, WO2011154737 discloses, as experimental Example 2.02 on page 60, the compound 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)—S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine (hereafter referred to as the compound of Formula (I)). The structure of the compound of Formula (I) is shown below. A synthetic route to the compound of Formula (I) is described at pages 51 to 57, 66 and 67 of WO2011154737, and is summarised below in Scheme 1. 9. The process according to claim 8 , wherein the compound of Formula (XIII) is prepared by reacting a compound of Formula (VIII) with OH—Rwherein Ris a phthalimide or tetrachlorophthalimide group.17. The compound according to any or claim 8 , wherein LGis chlorine and LG claim 8 , if present claim 8 , is chlorine.18. Use of a compound of any one of to claim 8 , or a salt thereof claim 8 , as a pharmaceutical intermediate.21. A process for preparing a compound of Formula (I) as claimed in claim 20 , wherein step (i) further comprises the addition of diethanolamine after reaction with a boron reagent in the presence of a palladium catalyst.24. The process for preparing a compound of Formula (I) as claimed in any of to claim 20 , further comprising the steps:(a) cyclopropanating a compound of Formula (IX) followed by hydrolysis to form a compound of Formula (VIII);(b) reacting a compound of Formula (VIII) with an acylating agent to form a compound of Formula (VII);(c) reacting a compound of Formula (VII) with urea or thiourea to form a compound of Formula (VI);(d) reacting a compound of Formula (VI) with a suitable reagent to form a compound of Formula (V);(e) reacting a compound of ...

Подробнее
Номер записи: 55
06-02-2020 дата публикации

SYNTHESIS AND CHARACTERIZATION OF RU ALKYLIDENE COMPLEXES

Номер: US20200038851A1
Автор: BEERMAN Jennifer A., CHU Crystal K., FIAMENGO Bryan A., GRUBBS Robert H., HERRON Jessica R., Johns Adam M., Lin Tzu-Pin, Pederson Richard L.
Принадлежит:

This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry. 8. The olefin metathesis catalyst according to claim 7 , wherein{'sup': '1', 'Xis Cl;'}{'sup': '2', 'Xis Cl;'}{'sup': '1', 'Ris morpholino, thiomorpholino, 1-methyl-piperazino, piperidino, N-acetyl-piperazino, di-benzyl-amino, N-ethylcarboxylate-piperazino, diethylamino, methyl-phenylamino, or di-iso-propylamino;'}{'sup': '2', 'Ris phenyl, morpholino, thiomorpholino, 1-methyl-piperazino, piperidino, N-acetyl-piperazino, di-benzyl-amino, N-ethylcarboxylate-piperazino, diethylamino, methyl-phenylamino, or di-iso-propylamino; and'}{'sup': '3', 'Ris phenyl or morpholino.'}11. The method according to claim 10 , wherein:{'sup': '1', 'Xis Cl;'}{'sup': '2', 'Xis Cl;'}{'sup': '1', 'Ris morpholino, thiomorpholino, 1-methyl-piperazino, piperidino, N-acetyl-piperazino, di-benzyl-amino, N-ethylcarboxylate-piperazino, diethylamino, methyl-phenylamino, or di-iso-propylamino;'}{'sup': '2', 'Ris phenyl, morpholino, thiomorpholino, 1-methyl-piperazino, piperidino, N-acetyl-piperazino, di-benzyl-amino, N-ethylcarboxylate-piperazino, diethylamino, methyl-phenylamino, or di-iso-propylamino; and'}{'sup': '3', 'Ris phenyl or morpholino'}{'sup': '5', 'Ris 2,4,6-trimethylphenyl;'}{'sup': '6', 'Ris 2,4,6-trimethylphenyl;'}{'sup': 'd', 'Ris phenyl;'}{'sup': 'e', 'Ris phenyl; and'}{'sup': 'f', 'Ris phenyl, methyl, p-(OMe)phenyl, or iso-propyl.'}13. The method according to claim 12 , wherein:{'sup': '1', 'Ris morpholino, thiomorpholino, 1-methyl-piperazino, piperidino, N-acetyl-piperazino, di-benzyl-amino, N-ethylcarboxylate-piperazino, diethylamino, ...

Подробнее
Номер записи: 56
18-02-2021 дата публикации

Method for Aerobic Oxidative Coupling of Thiophenes with a Ligand-Supported Palladium Catalyst

Номер: US20210047285A1
Автор: Stahl Shannon, Tereniak Stephen
Принадлежит:

An oxidative homocoupling method of synthesizing certain 2,2′-bithiophenes from thiophenes using oxygen as the terminal oxidant is disclosed. In non-limiting examples, the method uses oxygen along with a catalytic system that includes palladium, an assistive ligand, and a non-palladium metal additive to catalyze one of the following reactions: 1. A catalytic system for catalyzing the synthesis of a 2 ,2′-bithiophene or analog thereof from two thiophenes or analogs thereof , comprising:oxygen gas;palladium;a transition metal, alkali metal, alkaline earth metal, bismuth salt, or aluminum salt; anda ligand.2. The catalytic system of claim 1 , wherein the palladium is in the form of dipalladium(0) tris(dibenzylideneacetylacetone).3. The catalytic system claim 1 , wherein the palladium is in the form of a palladium salt.4. The catalytic system of claim 3 , wherein the palladium salt is selected from the group consisting of palladium(II) acetate claim 3 , palladium(II) propionate claim 3 , palladium(II) pivalate claim 3 , palladium(II) benzoate claim 3 , palladium(II) acetylacetonate claim 3 , palladium(II) trifluoroacetate claim 3 , palladium(II) nitrate dihydrate claim 3 , and palladium(II) iodide.5. The catalytic system of claim 1 , wherein the ligand is selected from the group consisting of a 1 claim 1 ,10-phenanthroline-5 claim 1 ,6-dione; a 2 claim 1 ,2′-bipyridine claim 1 , a 2 claim 1 ,2′-bipyrimidine; a 4 claim 1 ,5-diazafluoren-9-one; a quinoline; a 1 claim 1 ,10-phenanthroline; a bis(arylimino)acenaphthene; and a 2 claim 1 ,2′-biquinoline.7. The catalytic system of claim 6 , wherein 1 claim 6 , 2 claim 6 , 3 claim 6 , 4 claim 6 , 5 or all 6 of R claim 6 , R claim 6 , R claim 6 , R claim 6 , Rand Rare hydrogen.8. The catalytic system of claim 7 , wherein all 6 of R claim 7 , R claim 7 , R claim 7 , R claim 7 , Rand Rare hydrogen (the ligand is 1 claim 7 ,10-phenanthroline-5 claim 7 ,6-dione (phd)).10. The catalytic system of claim 9 , wherein one or more of R ...

Подробнее
Номер записи: 57
01-05-2014 дата публикации

Materials and methods for immobilization of catalysts on surfaces and for selective electroless metallization

Номер: US20140121096A1
Автор: Ali Afzali-Ardakani, Mahmoud Mostafa Khojasteh, Sarah Jane Vella, Tricia Breen Carmichael
Принадлежит: International Business Machines Corp

A method of rendering a substrate catalytic to electroless metal deposition comprising the steps of: (a) depositing a ligating chemical agent on the substrate, which is capable of both binding to the substrate and ligating to an electroless plating catalyst; and (b) ligating the electroless plating catalyst to the ligating chemical agent, wherein the ligating chemical agent has the chemical structure: wherein n and m are each between about 1 and about 100.

Подробнее
Номер записи: 58
18-02-2016 дата публикации

PROCESS FOR THE DIASTEREOSELECTIVE PREPARATION OF RUTHENIUM COMPLEXES

Номер: US20160046658A1
Автор: LOTHSCHUETZ Christian, Saint-Dizier Alexandre Christian
Принадлежит: SYNGENTA PARTICIPATIONS AG

The present invention relates to a process for the preparation of a compound of formula (I), wherein X is —CH—, —CH—CH—, —CH—CH—CH— or —CH—CH—CH—CH—; Yis —CH—; —CH2—CH— or —NH—; Yis NHR, or SH; wherein Ris hydrogen, C-Calkyl or phenyl; R—and R, independently from each other, represent aliphatic or aromatic groups; Rand R, independently from each other, represent aliphatic or aromatic groups; Rand Rare each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI(R)n]m (II), wherein n is 1 and m is >1 which represents a polymeric structure if Ris a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if Ris a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 112° C. to 165° C. with a compound of formula (III), wherein R, R, Yand Yare as defmed under formula I, and a phosphane of formula IV R3R4P—X—PRR(iv), wherein R, R, R, Rand X are as defined under formula I. 2. A process according to for the preparation of a compound of formula I claim 1 , wherein{'sub': 2', '2', '2', '2, 'X is —CH—CH—CH—CH—.'}3. A process according to for the preparation of a compound of formula I claim 2 , wherein{'sub': '8', 'Ris cyclooctadiene or bicyclo[2.2.1]hepta-2,5-diene if n is 1 and m >1; or is dimethylsulfoxide if n is 4 and m is 1.'}4. A process according to for the preparation of a compound of formula I claim 2 , wherein{'sub': 1', '2', '3', '4, 'R, R, Rand Rare phenyl and'}{'sub': 5', '6, 'Rand Rare hydrogen or together represent with the carbon atoms to which they are bonded, a phenyl ring;'}{'sub': 1', '2, 'Yis —CH—, and'}{'sub': 2', '2, 'Yis NH.'}6. A process according to performed as a one pot procedure. The present invention relates to a process for the diastereoselective ...

Подробнее
Номер записи: 59
01-05-2014 дата публикации

Methods of Activating Metal Complexes for Catalysts

Номер: US20140121427A1
Автор: Alexander Katz, Alexander Okrut, Igor Busygin, Ron C. Runnebaum, Xiaoying Ouyang
Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention is directed to the activation of metal carbonyl clusters by an oxidative agent to prepare a stable metal cluster catalyst exhibiting catalytic rate enhancement. The activation comprises, for example, using oxygen for decarbonylation of carbonyl ligands and changing the oxidation state of the other ligands. In one aspect, treatment of the metal cluster catalyst under oxidative conditions in a flow reactor leads to removal of CO ligands and oxidation of bound calixarene phosphine ligands, and results in a stable activated open metal cluster that is more active for ethylene hydrogenation catalysis. The resulting metal cluster contains coordinatively unsaturated sites comprising carbonyl vacancies. In one aspect, the resulting activated open metal cluster can be used as a catalyst in a variety of chemical transformations.

Подробнее
Номер записи: 60
16-02-2017 дата публикации

Ruthenium complex, method for producing same, and use of same

Номер: US20170044196A1
Автор: Hideki Nara, Osamu Ogata, Yuji Nakayama
Принадлежит: Takasago International Corp

The present invention provides a novel ruthenium complex that is easy to produce and handle and that can be supplied relatively inexpensively, a method for producing this ruthenium complex, a method for producing alcohols and the like using this ruthenium complex as a catalyst, a method for producing carbonyl compounds using this ruthenium complex as a catalyst, and a method for producing N-alkylamine compounds using this ruthenium complex as a catalyst. The present invention pertains to a ruthenium complex represented by general formula (1) RuX 1 X 2 (PNP) (NHC) m (Solv) n (1) (in general formula (1), X 1 and X 2 each independently represent a monovalent anionic monodentate ligand; PNP represents a tridentate aminodiphosphine ligand, NHC represents an N-heterocyclic carbene derived from a nitrogen-containing heterocyclic ring, and Solv represents a coordinating solvent; and m represents an integer from 1 to 3, n represents an integer from 0 to 2, and 1≦m+n≦3.), a method for producing the same, a catalyst including the same, and methods for producing various organic compounds using this catalyst.

Подробнее
Номер записи: 61
19-02-2015 дата публикации

Rhodium catalyst and method for producing amine compound

Номер: US20150051416A1
Автор: Hirotsugu Usutani, Masatoshi Yamada, Mitsuhisa Yamano
Принадлежит: Takeda Pharmaceutical Co Ltd

[Problem] Provision of a superior rhodium catalyst and a production method of amine compound. [Solving Means] A rhodium complex coordinated with a compound represented by the formula

Подробнее
Номер записи: 62
03-03-2022 дата публикации

HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION

Номер: US20220064080A1
Автор: HU Songshuang, Li Tonglin, Liu Jun, Pan Feng, Wang Xiaoqing, Wu Hongfei, Xu Ke, Zheng Mingfang
Принадлежит:

A halogen-containing compound as shown in a formula I can be used as a ligand for an ethylene oligomerization catalyst composition. The ethylene oligomerization catalyst composition containing the halogen-containing compound can be used to catalyze ethylene oligomerization, trimerization, and tetramerization reactions. As a ligand of a catalyst for ethylene oligomerization, a fluoropolymer can effectively improve the catalytic performance of a catalyst system, and particularly exhibits improved activity and selectivity in an ethylene oligomerization reaction.

Подробнее
Номер записи: 63
14-02-2019 дата публикации

PD-CATALYZED DECOMPOSITION OF FORMIC ACID

Номер: US20190047855A1
Автор: Beller Matthias, DONG Kaiwu, Franke Robert, Jackstell Ralf, Liu Jie, SANG Rui
Принадлежит: EVONIK DEGUSSA GmbH

Process for Pd-catalyzed decomposition of formic acid 2. Process according to claim 1 ,wherein the compound in process step b) is selected from:{'sub': 2', '2', '3', '3', '2', '2', '3', '2, 'Pd(acac), PdCl, Pd(dba)*CHCl (dba=dibenzylideneacetone), Pd(OAc), Pd(TFA), Pd(CHCN)Cl.'}3. Process according to claim 1 ,{'sub': '2', 'wherein the compound in process step b) is Pd(OAc).'}4. Process according to claim 1 ,wherein the process comprises additional process step f):f) addition of an acid.5. Process according to claim 4 ,{'sub': 2', '4', '3', '3', '3', '3, 'wherein the acid in process step f) is selected from: HSO, CHSOH, CFSOH, PTSA.'}6. Process according to claim 4 ,wherein the acid in process step f) is PTSA.7. Process according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 1', '12', '1', '12', '4', '14', '4', '14', '1', '12', '1', '12', '3', '14', '3', '14', '2, 'wherein R, R, R, Rare each independently selected from: —(C-C)-alkyl, —O—(C-C)-alkyl, —(C-C)-aryl, —O—(C-C)-aryl, cycloalkyl, —(C-C)-heteroalkyl, —O—(C-C)-heteroalkyl, —(C-C)-heteroaryl, —O—(C-C)-heteroaryl, —COO-alkyl, —COO-aryl, —C—O-alkyl, —C—O-aryl, NH, halogen and the residues are also capable of forming a larger condensed ring;'}wherein the recited alkyl groups, aryl groups, cycloalkyl, heteroalkyl groups, heteroaryl groups may be substituted as follows:{'sub': 1', '12', '1', '12, '—(C-C)-alkyl, —O—(C-C)-alkyl, halogen;'}{'sup': 1', '2', '3', '4, 'and at least one of the radicals R, R, R, Rdoes not represent phenyl.'}8. Process according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 1', '12', '4', '14', '1', '12', '3', '14, 'wherein R, R, R, Rare each independently selected from: —(C-C)-alkyl, —(C-C)-aryl, cycloalkyl, —(C-C)-heteroalkyl, —(C-C)-heteroaryl, halogen and the residues are also capable of forming a larger condensed ring;'}wherein the recited alkyl groups, aryl groups, cycloalkyl, heteroalkyl groups, heteroaryl groups may be substituted as follows:{'sub': 1', '12', '1', '12, '—(C-C)-alkyl, ...

Подробнее
Номер записи: 64
14-02-2019 дата публикации

METHOXYCARBONYLATION WITH FORMIC ACID AS CO SOURCE

Номер: US20190047935A1
Автор: Beller Matthias, DONG Kaiwu, Franke Robert, Jackstell Ralf, Liu Jie, SANG Rui
Принадлежит: EVONIK DEGUSSA GmbH

Process for methoxycarbonylation with formic acid as the CO source. 2. Process according to claim 1 ,wherein no CO gas is supplied to the reaction mixture,3. Process according to claim 1 ,wherein HCOOH serves as the only CO source for the reaction,4. Process according to claims 1 ,wherein the compound in process step b) is selected from:{'sub': 2', '2', '3', '3', '2', '2', '3', '2, 'Pd(acac), PdCl, Pd(dba)*CHCl (dba=dibenzylideneacetone), Pd(OAc), Pd(TFA), Pd(CHCN)Cl.'}5. Process according to claim 1 ,wherein the process comprises additional process step f):f) addition of an acid.6. Process according to claim 5 ,{'sub': 2', '4', '3', '3', '3', '3, 'wherein the acid is selected from: HSO, CHSOH, CFSOH, PTSA.'}7. Process according to claim 1 ,wherein the MeOH/HCOOH ratio based on the employed volume is in the range from 1.5:0.5 to 1.2:0.8.8. Process according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 1', '12', '1', '12', '4', '14', '4', '14', '1', '12', '1', '12', '3', '14', '3', '14', '2, 'wherein R, R, R, Rare each independently selected from: —(C-C)-alkyl, —O—(C-C)-alkyl, —(C-C)-aryl, —O—(C-C)-aryl, cycloalkyl, —(C-C)-heteroalkyl, —O—(C-C)-heteroalkyl, —(C-C)-heteroaryl, —O—(C-C)-heteroaryl, —COO-alkyl, —COO-aryl, —C—O-alkyl, —C—O-aryl, NH, halogen and the residues are also capable of forming a larger condensed ring;'}wherein the recited alkyl groups, aryl groups, cycloalkyl, heteroalkyl groups, heteroaryl groups may be substituted as follows:{'sub': 1', '12', '1', '12, '—(C-C)-alkyl, —O—(C-C)-alkyl, halogen;'}{'sup': 1', '2', '3', '4, 'and at least one of the radicals R, R, R, Rdoes not represent phenyl.'}9. Process according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 1', '12', '4', '14', '1', '12', '3', '14, 'wherein R, R, R, Rare each independently selected from: —(C-C)-alkyl, —(C-C)-aryl, cycloalkyl, —(C-C)-heteroalkyl, —(C-C)-heteroaryl, halogen and the residues are also capable of forming a larger condensed ring;'}wherein the recited alkyl groups, aryl ...

Подробнее
Номер записи: 65
14-02-2019 дата публикации

METHOXYCARBONYLATION WITH FORMIC ACID AND METHANOL

Номер: US20190047936A1
Автор: Beller Matthias, DONG Kaiwu, Franke Robert, Jackstell Ralf, Liu Jie, SANG Rui
Принадлежит: EVONIK DEGUSSA GmbH

Process for methoxycarbonylation with formic acid and methanol. 2. Process according to claim 1 ,wherein no CO gas is supplied to the reaction mixture.3. Process according to claim 1 ,wherein HCOOH serves as the only CO source for the reaction.4. Process according to claim 1 ,wherein the compound in process step b) is selected from:{'sub': 2', '2', '3', '3', '2', '2', '3', '2, 'Pd(acac), PdCl, Pd(dba)*CHCl (dba=dibenzylideneacetone), Pd(OAc), Pd(TFA), Pd(CHCN)Cl.'}5. Process according to claim 1 ,wherein the process comprises the additional process step g):g) addition of an acid.6. Process according to claim 5 ,{'sub': 2', '4', '3', '3', '3', '3, 'wherein the acid is selected from: HSO, CHSOH, CFSOH, PTSA.'}7. Process according to claim 1 ,wherein the employed volume of HCOOH based on 2 mmol of olefin is in the range from 0.4 ml to 0.6 ml.8. Process according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 1', '12', '1', '12', '4', '14', '4', '14', '1', '12', '1', '12', '3', '14', '3', '14', '2, 'wherein R, R, Rand Rare each independently selected from: —(C-C)-alkyl, —O—(C-C)-alkyl, —(C-C)-aryl, —O—(C-C)-aryl, cycloalkyl, —(C-C)-heteroalkyl, —O—(C-C)-heteroalkyl, —(C-C)-heteroaryl, —O—(C-C)-heteroaryl, —COO-alkyl, —COO-aryl, —C—O-alkyl, —C—O-aryl, NH, halogen and the residues are also capable of forming a larger condensed ring;'}wherein the recited alkyl groups, aryl groups, cycloalkyl, heteroalkyl groups, heteroaryl groups may be substituted as follows:{'sub': 1', '12', '1', '12, '—(C-C)-alkyl, —O—(C-C)-alkyl, halogen;'}{'sup': 1', '2', '3', '4, 'and at least one of the radicals R, R, R, Rdoes not represent phenyl.'}9. Process according to claim 1 ,{'sup': 1', '2', '3', '4, 'sub': 1', '12', '4', '14', '1', '12', '3', '14, 'wherein R, R, Rand Rare each independently selected from: —(C-C)-alkyl, —(C-C)-aryl, cycloalkyl, —(C-C)-heteroalkyl, —(C-C)-heteroaryl, halogen and the residues are also capable of forming a larger condensed ring;'}wherein the recited alkyl groups, ...

Подробнее
Номер записи: 66
13-02-2020 дата публикации

METHODS TO REJUVENATE A DEACTIVATED HYDROFORMYLATION CATALYST SOLUTION

Номер: US20200047171A1
Автор: Brammer Michael A., Eisenschmid Thomas C., Felsted, II William N.
Принадлежит:

Disclosed herein are methods to rejuvenate a deactivated hydroformylation catalyst solution wherein the solution comprises rhodium, polydentate phosphine ligands, and polydentate phosphine ligand degradation products. In one embodiment, such methods comprise adding a peroxide to the deactivated hydroformylation catalyst solution. 1. A method to rejuvenate a deactivated hydroformylation catalyst solution comprising rhodium , polydentate phosphine ligands , and polydentate phosphine ligand degradation products , the method comprising: adding a peroxide to the deactivated hydroformylation catalyst solution.2. The method of claim 1 , further comprising adding additional polydentate phosphine ligand to the catalyst solution after the addition of peroxide.3. The method of claim 1 , wherein the temperature of the deactivated hydroformylation catalyst solution is between 0° C. and 40° C. when the peroxide is added.4. The method of claim 1 , wherein the deactivated hydroformylation catalyst solution further comprises at least one product aldehyde claim 1 , and further comprising removing a majority of the product aldehyde prior to adding the peroxide.5. The method of claim 4 , wherein a majority of the product aldehyde is removed by vaporization.6. The method of claim 4 , wherein the temperature of the deactivated hydroformylation catalyst solution is 70° C. or greater when the peroxide is added.7. The method of claim 4 , wherein the temperature of the deactivated hydroformylation catalyst solution is 100° C. or greater when the peroxide is added.8. The method of claim 4 , wherein the peroxide comprises hydrogen peroxide claim 4 , peroxy esters claim 4 , peroxydicarbonates claim 4 , dialkyl peroxides claim 4 , hydroperoxides claim 4 , peroxyketals claim 4 , or a combination thereof. The present disclosure relates generally to methods for rejuvenating deactivated hydroformylation catalyst solutions and in particular, to methods for rejuvenating deactivated hydroformylation ...

Подробнее
Номер записи: 67
25-02-2016 дата публикации

METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS

Номер: US20160052854A1
Автор: CHAKADAJ Wojciech, GE Shaozhong, Hartwig John F.
Принадлежит:

The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described. 2. The composition according to claim 1 , wherein said complex is present in said composition in an amount of less than 10 mol % relative to said α claim 1 ,α-difluoromethyl carbonyl compound.3. The composition according to claim 2 , wherein said complex is present in said composition in an amount of about 2 mol % to about 5 mol % relative to said α claim 2 ,α-difluoromethyl carbonyl compound.5. The composition according to claim 4 , wherein said complex is present in said composition in an amount of less than 10 mol % relative to said silyl enol ether.6. The composition according to claim 5 , wherein said complex is present in said composition in an amount of about 2 mol % to about 5 mol % relative to said silyl enol ether.76. The composition according to any one of - claims 4 , wherein said composition does not contain BuSnF.87. The composition according to any one of - claims 4 , wherein said composition does not contain an organotin reagent.98. The composition according to any one of - claims 4 , wherein R claims 4 , R claims 4 , and Rare independently selected from unsubstituted C claims 4 , C claims 4 , C claims 4 , C claims 4 , Cand Calkyl.10. The composition according to claim 9 , wherein one or more of R claim 9 , R claim 9 , and Rare methyl.11. The composition according to any preceding claim claim 9 , further comprising a solvent.12. The composition according to claim 11 , wherein said solvent is a non-polar claim 11 , organic solvent.13. The composition according to claim 12 , wherein said solvent is toluene.14. The composition according to any preceding claim claim 12 , wherein said base is a member selected from CsCOand KPO.17. The composition ...

Подробнее
Номер записи: 68
23-02-2017 дата публикации

N-SUBSTITUTED PYRIDINIOPHOSPHINES, PROCESSES FOR THEIR PREPARATION AND THEIR USE

Номер: US20170050180A1
Автор: ALCARAZO Manuel, TINNERMANN Hendrik, WILLE Christian
Принадлежит: STUDIENGESELLSCHAFT KOHLE MBH

The present invention deals with the synthesis and applications of new cationic compounds being useful as metal ligands. Specifically, N-alkyl/aryl substituted pyridiniophosphines are prepared and used as ligands for transition metals. The so-obtained metal complexes and their use as catalysts in chemical synthesis is also described. It also worth mentioning that N-alkyl/aryl pyridiniophosphines can be synthesized through a short, scalable and highly modular route. 2. N-substituted pyridiniophosphine of the general formula (I) according to claim 1 , wherein R claim 1 , Rand Reach represent hydrogen and Rrepresents halogen claim 1 , a linear claim 1 , cyclic or branched C-C-alkyl claim 1 , -alkenyl or -alkynyl group or C-C-aryl or -heteroaryl group claim 1 , which can have suitable substituents selected from halogen claim 1 , ═O claim 1 , —OH claim 1 , —OR claim 1 , —NH claim 1 , —NHR claim 1 , —NR claim 1 , aryl or Ris bound to the pyridinio ring via —O— or —NR—; and{'sup': 5', '6', '7', '−, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'R, R, R, R and X have the meaning as given in .'}3. N-substituted pyridiniophosphine of the general formula (I) according to claim 1 , wherein X is an anion selected from Cl claim 1 , Br claim 1 , I claim 1 , PF claim 1 , SbF claim 1 , BF claim 1 , ClO claim 1 , FCCOO claim 1 , TfN claim 1 , (Tf=trifluoromethanesulfonyl) claim 1 , TfO claim 1 , tosyl claim 1 , [B[3 claim 1 ,5-(CF)CH]] claim 1 , [B(CF)] claim 1 , and [Al(OC(CF))].5. A metal complex comprising as a ligand a N-substituted pyridiniophosphine of the general formula (I) according to .7. The metal complex as claimed in claim 6 , wherein the ligand L can be chosen from halogen claim 6 , CN claim 6 , CO claim 6 , alkenes claim 6 , cycloalkenes and/or alkynes claim 6 , arenes claim 6 , nitriles claim 6 , phosphines claim 6 , amines claim 6 , pyridines or carboxylates.8. The metal complex as claimed in claim 6 , wherein M is selected from Ag claim 6 , Au claim 6 , Ru claim ...

Подробнее
Номер записи: 69
13-02-2020 дата публикации

METHODS FOR ENANTIOSELECTIVE ALLYLIC ALKYLATION OF ESTERS, LACTONES, AND LACTAMS WITH UNACTIVATED ALLYLIC ALCOHOLS

Номер: US20200048201A1
Автор: Bachman Shoshana, Jette Carina I., Lackner Sebastian, Ngamnithiporn Aurapat, Stoltz Brian M., Virgil Scott C.
Принадлежит:

The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation. 113-. (canceled)15. The method of claim 14 , wherein:{'sub': '2', 'the Ni(0) source is Ni(COD);'}L is (S)—C3-TunePhos; andthe organic solvent is diethyl ether.16. The method of claim 14 , wherein:{'sub': '6', 'Ris methyl; and'}{'sub': '7', 'Ris methyl.'}17. (canceled)18. The method of claim 15 , wherein:{'sub': '6', 'Ris methyl; and'}{'sub': '7', 'Ris methyl.'}19. A method comprising{'claim-ref': {'@idref': 'CLM-00014', 'claim 14'}, 'preparing a compound of Formula (XI) according to ; and'}synthesizing a pharmaceutical agent from the compound of Formula (XI).21. The method of claim 20 , wherein:{'sub': '2', 'the Ni(0) source is Ni(COD);'}L is (S)—C3-TunePhos; andthe organic solvent is diethyl ether.22. The method of claim 20 , wherein:{'sub': '6', 'Ris methyl; and'}{'sub': '7', 'Ris methyl.'}23. The method of claim 21 , wherein:{'sub': '6', 'Ris methyl; and'}{'sub': '7', 'Ris methyl.'} This Application claims the benefit of U.S. Provisional Application 62/580,091, filed Nov. 1, 2017, the contents of which are hereby incorporated herein by reference.This invention was made with government support under Grant Nos. GM080269 awarded by the National Institutes of Health. The Government has certain rights in the invention.Synthetic methods for the generation of enantioenriched quaternary stereocenters are highly desirable given their prevalence as motifs in a wide variety of biologically active molecules of both natural and unnatural origin, and the pharmaceutical industries increasing recognition for the motif's applicability in drug design. Despite their importance, the number of highly enantioselective transformations that construct quaternary stereocenters under mild reaction conditions is limited, with respect to both cyclic and acyclic systems.Since 1965, transition metal-catalyzed allylic ...

Подробнее
Номер записи: 70
10-03-2022 дата публикации

Halogen-containing compound and use thereof as catalyst ligand in ethylene oligomerization

Номер: US20220072523A1
Автор: Feng Pan, Hongfei Wu, Jun Liu, Ke Xu, Mingfang Zheng, Songshuang HU, Tonglin Li, Xiaoqing Wang
Принадлежит: Beijing Research Institute Of Chemical Industry China Petroleum & Chemical Corporated, China Petroleum and Chemical Corp, Sinopec Beijing Research Institute of Chemical Industry

A halogen-containing compound represented by a formula I and a use thereof as a ligand of an ethylene oligomerization catalyst composition, an ethylene oligomerization catalyst composition comprising the halogen-containing compound, and an ethylene oligomerization method, ethylene trimerization method and ethylene tetramerization method using the catalyst composition. Serving as the ligand of the ethylene oligomerization catalyst, the halogen-containing polymer may effectively improve the catalytic performance of a catalyst system, especially by displaying a significantly improved catalytic performance in an ethylene oligomerization reaction. The maximum catalyst activity may exceed 4×108 g·mol(Cr)−1·h−1, and the total selectivity of 1-hexene and 1-octene exceeds 92 wt %. In a C6 product, the content of 1-hexene may reach about 97%, and in a C8 product, the content of 1-octene may reach more than 98%. The present catalyst composition has good industrial application prospects and economic value.

Подробнее
Номер записи: 71
10-03-2022 дата публикации

REVERSIBLE LIQUID ORGANIC SYSTEM FOR LOADING AND DISCHARGING HYDROGEN BASED ON ETHYLENE GLYCOL

Номер: US20220073344A1
Автор: ANABY Aviel, Milstein David, ZHOU You-Quan
Принадлежит: Yeda Research and Development Co., Ltd.

This invention provides a reversible hydrogen loading and discharging system and a reversible method for loading and discharging hydrogen. The system and the methods of this invention comprise ethylene glycol as a liquid organic hydrogen carrier and at least one transition metal. By reacting ethylene glycol with at least one transition metal; at least one hydrogen molecule and at least one oligoester of ethylene glycol are formed (hydrogen releasing)⋅, and by reacting at least one oligoester of ethylene glycol with at least one transition metal and at least one hydrogen molecule, at least one ethylene glycol is formed (hydrogen loading). 1. A reversible hydrogen loading and discharging system comprising: ethylene glycol as a liquid organic hydrogen carrier and at least one transition metal.2. The system according to claim 1 , wherein the system comprises a reaction chamber configured to collect the LOHC and the catalyst of the invention; a heating element configured to heat the LOHC and the catalyst to release hydrogen; a buffer tank in flow communication with the reaction chamber configured to collect and temporarily store the hydrogen; a compressor system in flow communication with the buffer tank configured to pressurize the hydrogen to a selected pressure; a storage system in flow communication with the compressor system configured to store a selected quantity of the hydrogen; a dispensing system in flow communication with the storage system configured to dispense the hydrogen to a hydrogen fuel cell or to the internal combustion engine.3. The reversible hydrogen loading and discharging system according to claim 1 , wherein said at least one transition metal is selected from Mn claim 1 , Fe claim 1 , Co claim 1 , Ni claim 1 , Ru claim 1 , Rh claim 1 , Pd claim 1 , Cu claim 1 , Ag or any combinations thereof.4. The reversible hydrogen loading and discharging system according to claim 1 , wherein said at least one transition metal is coordinated to at least one ...

Подробнее
Номер записи: 72
20-02-2020 дата публикации

O-AMINOHETEROARYL ALKYNYL-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF

Номер: US20200055838A1
Автор: AI Jing, DAI Yang, DING Jian, Geng Meiyu, GUAN Xiaocong, Hu Youhong, Liu Yang, Peng Xia, Ren Wenming, WANG Lang, ZENG Limin
Принадлежит:

An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses. 2. The compound claim 1 , or the deuterated compound claim 1 , or the pharmaceutically acceptable salt or the prodrug thereof of claim 1 , wherein:the alkyl is a saturated aliphatic straight or branched alkyl having 1 to 6 carbon atoms, preferably having 1 to 4 carbon atoms, more preferably 1 to 3 carbon atoms, and still more preferably is methyl, ethyl, propyl, isopropyl or tert-butyl;the modified alkyl is an alkyl having one or more substituents selected from the group consisting of —O—, —COO—, —CONH—, —CH═CH—, —C≡C—, halogen, hydroxyl, carboxyl, primary amino, secondary amino, tertiary amino, cycloalkyl, heterocyclyl, and heterocyclylene;the aryl is a 6-10 membered and preferably 6-8 membered monocyclic or fused bicyclic ring;the heteroaryl or heteroaryl ring is a 6-10 membered and preferably 6-8 membered monocyclic or fused bicyclic ring containing 1-3 heteroatoms selected from N, O and S;the cycloalkyl is a saturated or unsaturated 3-6 membered monocyclic or polycyclic ring;the cycloalkylene is a saturated or unsaturated 3-6 membered monocyclic or polycyclic ring;the heterocyclyl is a 4-7 membered and preferably 4-6 membered monocyclic or polycyclic heterocycle containing 1-3 heteroatoms selected from N, O, and S;the ...

Подробнее
Номер записи: 73
27-02-2020 дата публикации

PROCESS FOR PREPARING BTK INHIBITORS

Номер: US20200062762A1
Автор: Bachmann Stephan, BEAUDRY Danial, CRAVILLION Theresa, Fettes Alec, GMEHLING Alexander, Gosselin Francis, LIM Ngiap-Kie, Malhotra Sushant, Tian Qingping, Zhang Haiming
Принадлежит: Genentech, Inc.

Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided. 2. The method of claim 1 , wherein the volume to weight ratio of the solvent system to compound 170 in the reaction mixture is from about 5:1 to about 20:1 liters per kg.3. The method of claim 1 , wherein:{'sub': 3', '4, 'the base in the first reaction mixture is KPO, and the solvent system in the first reaction mixture comprises water and a polar aprotic solvent, wherein the volume ratio of water to polar aprotic solvent is from about 0.1:1 to about 0.4:1.'}4. The method of claim 1 , wherein:the yield of compound 190 is at least 80%, and the purity of compound 190 is at least 99 area %.6. The method of claim 5 , wherein the ratio of the solvent volume to compound 160 weight in the reaction mixture is from about 5:1 to about 15:1 liters per kg claim 5 , and wherein the equivalent ratio of catalyst to compound 160 is from about 0.01:1 to about 0.03:1.7. The method of claim 6 , wherein the catalyst is Pd(OAc) claim 6 , the ligand is DPPF claim 6 , the base is potassium carbonate claim 6 , and the polar aprotic solvent is tetrahydrofuran.89-. (canceled)11. The method of claim 10 , wherein the reaction mixture comprises: a ratio of solvent volume to compound 180 weight of from about 5:1 to about 20:1 liters to kg; an equivalent ratio of borylation reagent to compound 180 of between 1 and 2; an equivalent ratio of palladium catalyst to compound 180 of from 0.001:1 to about 0.005:1; an equivalent ratio of catalyst ligand to catalyst of from about 1.5:1 to about 3; and an equivalent ratio of potassium acetate to compound 180 of greater than 1:1.13. The method of wherein the catalyst ligand is XPhos. ...

Подробнее
Номер записи: 74
11-03-2021 дата публикации

SYNTHESIS OF COELENTERAZINE

Номер: US20210070762A1
Автор: Bhatt Rama, Duvvuru Rajagopala Reddy, Kumar Anil
Принадлежит: INTERNATIONAL PAPER COMPANY

Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products. 1. A method of making coelenterazine , comprising:(a) reacting 3-benzylpyrazin-2-amine (25) with N-bromosuccinimide to provide 3-benzyl-5-bromopyrazin-2-amine (2);(b) reacting the 3-benzyl-5-bromopyrazin-2-amine (2) in two sequential steps to provide 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7) (coelenteramine); and(c) coupling the 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7) with silyl-protected 1,1-diethoxy-3-(4-hydroxyphenyl)propan-2-one to provide coelenterazine, or a salt thereof.2. The method of claim 1 , wherein (b) comprises a first step of reacting the 3-benzyl-5-bromopyrazin-2-amine (2) with 4-methoxyphenyl boronic acid (4) in the presence of a palladium catalyst to provide 3-benzyl-5-(4-methoxyphenyl)pyrazin-2-amine (5) claim 1 , and a second step of deprotecting the 3-benzyl-5-(4-methoxyphenyl)pyrazin-2-amine (5) to provide the 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7).3. The method of claim 1 , wherein the silyl protected 1 claim 1 ,1-diethoxy-3-(4-hydroxyphenyl)propan-2-one is 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1 claim 1 ,1-diethoxypropan-2-one (23) and wherein the 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1 claim 1 ,1-diethoxypropan-2-one (23) is synthesized by:i. reacting 4-hydroxybenzaldehyde (8) with tert-butyldimethylsilyl chloride to provide 4-((tert-butyldimethylsilyl)oxy)benzaldehyde;ii. reacting the 4-((tert-butyldimethylsilyl)oxy)benzaldehyde with sodium borohydride to provide (4-((tert-butyldimethylsilyl)oxy)phenyl)methanol;iii. reacting the (4-((tert-butyldimethylsilyl)oxy)phenyl)methanol with methanesulfonyl chloride to provide tert-butyl(4-(chloromethyl)phenoxy)dimethylsilane(21);iv. reacting the tert-butyl(4-(chloromethyl)phenoxy)dimethylsilane (21) with magnesium to provide (4-((tert- ...

Подробнее
Номер записи: 75
17-03-2016 дата публикации

LIGAND, NICKEL COMPLEX COMPRISING THE LIGAND, AND REACTION USING THE NICKEL COMPLEX

Номер: US20160074853A1
Автор: Itami Kenichiro, KOCH Eva, Takise Ryosuke, Yamaguchi Junichiro
Принадлежит:

An object of the present invention is to provide a method for directly performing arylation (particularly α-arylation) of carbonyl or thiocarbonyl compounds using a more inexpensive phenol derivative and nickel catalyst. Another object of the present invention is to provide a novel nickel catalyst that can be used in this method, and a novel ligand of the nickel catalyst. The novel compounds of the present invention are a compound having a diphosphine skeleton in which a five- or six-membered heterocyclic ring is substituted with two dialkylphosphines and/or dicycloalkylphosphines, or a salt thereof, and a compound having the diphosphine skeleton that is bound to nickel. Moreover, coupling reaction of a carbonyl compound and a phenol derivative can be advanced in the presence of a nickel compound having a monodentate or bidentate dialkylphosphine and/or dicycloalkylphosphine skeleton. 1. A compound having a diphosphine skeleton in which a five- or six-membered heterocyclic ring is substituted with two dialkylphosphines and/or dicycloalkylphosphines , or a salt thereof.3. The compound or a salt thereof according to claim 2 , wherein Rto Rin Formula (1) are the same or different claim 2 , and each is optionally substituted cycloalkyl.4. The compound or a salt thereof according to claim 1 , which is used to produce a catalyst for coupling reaction of a carbonyl compound and a phenol derivative.5. A compound having a diphosphine skeleton in which a five- or six-membered heterocyclic ring is substituted with two dialkylphosphines and/or dicycloalkylphosphines claim 1 , the diphosphine skeleton being bound to nickel.7. The compound according to claim 6 , wherein Rto Rin Formula (2) are the same or different claim 6 , and each is optionally substituted cycloalkyl.8. The compound according to claim 5 , which is a catalyst for coupling reaction of a carbonyl compound and a phenol derivative.9. A method for producing an arylcarbonyl compound claim 5 ,{'claim-ref': {'@idref': ...

Подробнее
Номер записи: 76
16-03-2017 дата публикации

CATALYSTS BASED ON AMINO-SULFIDE LIGANDS FOR HYDROGENATION AND DEHYDROGENATION PROCESSES

Номер: US20170073298A1
Автор: Goussev Dmitri, Smith Samantha, Spasyuk Denis
Принадлежит:

The present application discloses novel amino-sulfide metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for a variety of chemicals. 2. (canceled)3. (canceled)4. A process for dehydrogenation of a substrate comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'treating the substrate with a catalytic amount of a metal complex of .'}6. (canceled)7. The process of claim 5 , wherein the substrate comprises more than one hydroxyl moiety that undergoes dehydrogenation.8. (canceled)10. A process for producing Hcomprising dehydrogenation of a substrate by treating the substrate with a catalytic amount of a metal complex of .11. The process of claim 10 , wherein the substrate comprises an alcohol claim 10 , amine or thiol or wherein the substrate is ammonia-borane.12. (canceled)13. The process of claim 4 , wherein the process does not require a hydrogen acceptor.14. The process of claim 4 , which is a homogeneous process.15. A process for hydrogenation of a substrate comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'treating the substrate under a pressure of hydrogen with a catalytic amount of a metal complex of .'}16. The ...

Подробнее
Номер записи: 77
18-03-2021 дата публикации

ORGANORUTHENIUM CARBIDE COMPLEXES AS PRECATALYSTS FOR OLEFIN METATHESIS

Номер: US20210077988A1
Автор: Burtovyy Oleksandr, Gawin Rafal, RHODES LARRY F
Принадлежит:

Embodiments in accordance with the present invention encompass an organoruthenium compound of the formula (I) or formula (II): 2. The compound according to claim 1 , wherein:X is chlorine or iodine;{'sub': 1', '1, 'Rand Arare both substituted phenyl; and'}{'sub': '3', 'L is PR, where each R is independently selected from the group consisting of isopropyl, sec-butyl, tert-butyl, cyclohexyl and phenyl.'}3. The compound according to claim 1 , wherein:X is chlorine;{'sub': 1', '1, 'Rand Arare independently selected from the group consisting of phenyl, 2-methylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 2-ethylphenyl, 2,4-diethylphenyl, 2,6-diethylphenyl, 2,4,6-triethylphenyl, 2-isopropylphenyl and 2,6-diisopropylphenyl; and'}L is tri(isopropyl)phosphine or tricyclohexylphosphine.4. The compound according to claim 1 , wherein:X is chlorine;{'sub': 1', '1, 'Rand Arare independently selected from the group consisting of phenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 2,4-diethylphenyl, 2,6-diethylphenyl, 2,4,6-triethylphenyl, 2-isopropylphenyl and 2,6-diisopropylphenyl; and'}L is tricyclohexylphosphine.5. The compound according to claim 1 , wherein:X is iodine;{'sub': 1', '1, 'Rand Arare independently selected from the group consisting of 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 2,6-diethylphenyl, 2,4,6-triethylphenyl and 2,6-diisopropylphenyl; and'}L is tricyclohexylphosphine.7. A process for carrying out a metathesis reaction of olefins claim 1 , comprising contacting at least one olefin with the compound of as a procatalyst.8. The process according to claim 7 , wherein the metathesis reaction is carried out in an organic solvent.9. The process according to claim 8 , wherein the organic solvent is selected from the group consisting of dichloromethane claim 8 , dichloroethane claim 8 , toluene claim 8 , ethyl acetate and a mixture in any combination thereof.10. The process according to claim 7 , wherein the metathesis ...

Подробнее
Номер записи: 78
19-03-2015 дата публикации

Catalyst and process for the co-dimerization of ethylene and propylene

Номер: US20150080628A1
Автор: David William NORMAN, Joy Lynn Laningham
Принадлежит: Eastman Chemical Co

Disclosed are novel catalyst solutions comprising an organic complex of nickel, an alkyl aluminum compound, a solvent, and a phosphine compound, that are useful for the preparation of butenes, pentenes and hexenes by the co-dimerization or cross-dimerization of ethylene and propylene. Also disclosed are processes for the dimerization of ethylene and propylene that utilize these catalyst solutions. The catalyst systems described herein demonstrate that, depending on the choice of phosphine compound used with the catalytically active nickel, it is indeed possible to lower the concentration of hexene olefins relative to butenes and pentenes, even in the presence of excess propylene. The selectivity to the linear or branched pentene product can also be controlled by the selection of the phosphine compound. The catalyst solutions may be used with mixtures of olefins.

Подробнее
Номер записи: 79
18-03-2021 дата публикации

PROCESS FOR PREPARING BTK INHIBITORS

Номер: US20210079004A1
Автор: Bachmann Stephan, BEAUDRY Danial, CRAVILLION Theresa, Fettes Alec, GMEHLING Alexander, Gosselin Francis, LIM Ngiap-Kie, Malhotra Sushant, Tian Qingping, Zhang Haiming
Принадлежит: Genentech, Inc.

Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided. 2. The method of wherein the volume to weight ratio of the solvent system to compound 170 in the reaction mixture is from about 5:1 to about 20:1 liters per kg claim 1 , or about 10:1 liters per kg claim 1 , and the equivalent ratio of compound 181 to compound 170 is greater than 1:1 claim 1 , and the equivalent ratio of the palladium catalyst to compound 170 is from about 0.005:1 to about 0.02:1 claim 1 , or about 0.01:1.4. The method of wherein:the yield of compound 190 is at least 60%, at least 70%, at least 80% or at least 90%, and the purity of compound 190 is at least 99 area % or at least 99.5 area %; andthe yield of compound 200 is at least 60%, at least 70%, at least 80%, or at least 85%, and the purity of compound 200 is at least 99 area % or at least 99.5 area %.6. The method of wherein the ratio of the solvent volume to compound 160 weight in the reaction mixture is from about 5:1 to about 20:1 liters per kg claim 5 , from about 5:1 to about 15:1 liters per kg claim 5 , or about 10:1 liters per kg claim 5 , and wherein the equivalent ratio of catalyst to compound 160 is from about 0.01:1 to about 0.03:1.7. The method of wherein the catalyst is Pd(OAc) claim 6 , the ligand is DPPF claim 6 , the base is potassium carbonate claim 6 , and the solvent is tetrahydrofuran.9. The method of wherein the polar aprotic solvent is THF; the mole ratio of n-butyl lithium to compound 95 is between 1:1 and 2:1 claim 8 , or from about 1.2:1 to about 1.6:1; the first reaction mixture and the second reaction mixture are formed at a temperature of greater than −35° C.; of the solvent volume to ...

Подробнее
Номер записи: 80
22-03-2018 дата публикации

PROCESS FOR PRODUCING HETEROCYCLIC COMPOUND

Номер: US20180079741A1
Автор: Hirano Sayuri, Tsuruoka Ryoji, YAMADA Masatoshi, Yamano Mitsuhisa
Принадлежит: Takeda Pharmaceuticals Company Limited

The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate. 2. The method according to claim 1 , wherein the organic metal complex is a transition metal complex.3. The method according to claim 2 , wherein the transition metal complex is a ruthenium complex.4. The method according to claim 3 , wherein the ruthenium complex is represented by the formula:{'br': None, 'sup': 'a', 'sub': '2', '[Ru(OCOR)L*]\u2003\u2003(VIII)'}wherein{'sup': 'a', 'sub': '1-3', 'Ris an optionally substituted Calkyl group; and'}{'sup': 'a', 'Lis a diphosphine ligand.'} This application is a divisional of U.S. application Ser. No. 15/125,299, which is the U.S. National Stage application of PCT/JP2015/057541, filed Mar. 13, 2015, which claims priority from Japanese application 2014-052809, filed Mar. 14, 2014.The present invention relates to a production method of an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative which is useful as a dipeptidylpeptidase inhibitor, and various intermediates useful therefor, and production methods thereof.An optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative is known to be useful as a dipeptidylpeptidase inhibitor and an agent for the treatment of diabetes.Patent Document 1 discloses a method of producing a 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative by reacting optically active 3-aminopiperidine with a 6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative.Patent Document 2 discloses a method of efficiently producing an optically active 8-(3-aminopiperidin-1-yl)xanthine derivative by ...

Подробнее
Номер записи: 81
23-03-2017 дата публикации

PROCESS FOR PRODUCING HETEROCYCLIC COMPOUND

Номер: US20170081305A1
Автор: Hirano Sayuri, Tsuruoka Ryoji, YAMADA Masatoshi, Yamano Mitsuhisa
Принадлежит: Takeda Pharmaceutical Company Limited

The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative. 2. The method according to claim 1 , wherein the organic metal complex is a transition metal complex.3. The method according to claim 2 , wherein the transition metal complex is a ruthenium complex.4. The method according to claim 3 , wherein the ruthenium complex is represented by the formula:{'br': None, 'sup': a', 'a, 'sub': '2', '[Ru(OCOR)L]\u2003\u2003(VIII)'}wherein{'sup': 'a', 'sub': '1-3', 'Ris an optionally substituted Calkyl group; and'}{'sup': 'a', 'Lis a diphosphine ligand.'} The present invention relates to a production method of an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative which is useful as a dipeptidylpeptidase inhibitor, and various intermediates useful therefor, and production methods thereof.An optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative is known to be useful as a dipeptidylpeptidase inhibitor and an agent for the treatment of diabetes.Patent Document 1 discloses a method of producing a 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative by reacting optically active 3-aminopiperidine with a 6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative.Patent Document 2 discloses a method of efficiently producing an optically active 8-(3-aminopiperidin-1-yl)xanthine derivative by subjecting racemic 3-aminopiperidine to acylation with phthalic anhydride, subjecting the obtained 3-phthalimide piperidine to optical resolution with optically active tartaric acid, coupling the obtained optically resolved compound with a xanthine ring, and subjecting the obtained compound to deacylation.Patent Document 3 discloses a method of optically resolving racemic piperidine-3-carboxamide with optically active lactic acid.Patent Document 4 discloses a method of producing an optically ...

Подробнее
Номер записи: 82
31-03-2022 дата публикации

CO-FEEDING ETHYLENE WITH ALLYL ALCOHOL IN HYDROFORMYLATION TO MAKE 1,4-BUTANEDIOL AND N-PROPANOL

Номер: US20220098138A1
Автор: Alvarez Roberto, Mandimutsira Beaven S., White Daniel F.
Принадлежит: Lyondell Chemical Technology, L.P.

A process of co-feeding gaseous ethylene with liquid allyl alcohol in the presence of a catalyst to produce 1,4-butanediol and n-propanol may include: introducing a gaseous mixture of ethylene, carbon monoxide and hydrogen into a reactor in the presence of a hydroformylation catalyst in a solvent; introducing liquid allyl alcohol (AA) into the reactor; and carrying out hydroformylation reaction at a temperature between 50 and 100° C. to obtain hydroformylation products. 1. A method for producing an alcohol in a hydroformylation process , comprising the steps of:a) introducing a gaseous mixture of ethylene, carbon monoxide and hydrogen into a reactor in the presence of a hydroformylation catalyst in a solvent;b) introducing liquid allyl alcohol (AA) into the reactor; andc) carrying out hydroformylation reaction at a temperature between 50 and 100° C. to obtain hydroformylation products.2. The method of claim 1 , wherein the molar ratio of ethylene to allyl alcohol ranges from 1:3 to 1:7.3. The method of claim 1 , wherein the molar ratio of ethylene to allyl alcohol ranges from 1:4 to 1:5.5. The method of claim 1 , wherein molar ratio of ethylene:carbon monoxide:hydrogen is (0.18-0.35):(2.7-4.1):(5-7).6. The method of claim 5 , wherein the molar ratio of ethylene:carbon monoxide:hydrogen is about 1:13:22.7. The method of claim 1 , wherein in step c) the hydroformylation reaction is carried out at a moderate pressure in the range of from about 137.9 kPa to about 1378.95 kPa.8. The method of claim 1 , wherein in step c) the hydroformylation reaction is carried out at a moderate pressure in the range of from about 689.48 kPa to about 1034.21 kPa.9. The method of claim 1 , wherein in step c) the hydroformylation reaction is carried out at a moderate pressure in the range of from about 896.32 kPa to about 965.27 kPa.10. The method of claim 1 , wherein the hydroformylation catalyst is a mixture of rhodium and a ligand selected from the group consisting of trans-1 claim 1 ,2 ...

Подробнее
Номер записи: 83
12-06-2014 дата публикации

Catalysts and processes for the hydrogenation of amides

Номер: US20140163225A1
Автор: Jeremy M. JOHN, Steven BERGENS
Принадлежит: University of Alberta

There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.

Подробнее
Номер записи: 84
23-03-2017 дата публикации

CATALYST AND BATTERY COMPONENTS DERIVED FROM CONDENSATION REACTIONS WITH CARBA-CLOSO-DODECABORATE AMINES

Номер: US20170084954A1
Автор: CHAN Allen, EL HELLANI Ahmad, LAVALLO Vincent
Принадлежит:

Described herein is the fusion of two families of unique carbon-containing molecules that readily disregard the tendency of carbon to form four chemical bonds, namely N-heterocyclic carbenes (NHCs) and carborane anions. Deprotonation of an anionic imidazolium salt with lithium diisopropylamide at room temperature leads to a mixture of lithium complexes of C-2 and C-5 dianionic NHC constitutional isomers as well as a trianionic (C-2, C-5) adduct. Judicious choice of the base and reaction conditions allows for the selective formation of all three stable polyanionic carbenes. In solution, the so-called abnormal C-5 NHC lithium complex slowly isomerizes to the normal C-2 NHC, and the process can be proton catalyzed by the addition of the anionic imidazolium salt. These results indicate that the combination of two unusual forms of carbon atoms can lead to unexpected chemical behavior, and that this strategy paves the way for the development of a broad new generation of NHC ligands for catalysis. 2. The carborane compound according to claim 1 , wherein alkyl claim 1 , aryl claim 1 , silyl claim 1 , siloxy claim 1 , alkoxy claim 1 , and aryloxy in Rare optionally substituted with a member independently selected from the group consisting of hydrogen claim 1 , halogen claim 1 , hydroxyl claim 1 , and hydroxide.3. The carborane compound according to claim 1 , wherein Ris selected from alkyl and aryl.5. The carborane compound according to claim 1 , wherein Hetis selected from the group consisting of an N-heterocyclic carbene (NHC) moiety or an NHC precursor moiety.8. The carborane compound according to claim 7 , wherein{'sup': '1', 'each Ris independently selected from H, halogen, alkyl, aryl, silyl, siloxy, alkoxy, and aryloxy, and wherein'}{'sup': '1', 'each alkyl, aryl, silyl, siloxy, alkoxy, and aryloxy in Ris optionally substituted with a member independently selected from the group consisting of halogen, hydroxyl, and hydroxide.'}9. The carborane compound according to ...

Подробнее
Номер записи: 85
29-03-2018 дата публикации

METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN

Номер: US20180086684A1
Автор: TAKAHIRA Yusuke
Принадлежит: Asahi Glass Company, Limited

A method for producing at least one compound selected from the group consisting of a compound represented by the following formula (10), a compound represented by the following formula (11), a compound represented by the following formula (12), and a compound represented by the following formula (13), which the method containing reacting a compound represented by the following formula (2) with a compound represented by the following formula (7), in the presence of at least one compound selected from the group consisting of a compound represented by the following formula (1), a compound represented by the following formula (3), a compound represented by the following formula (4), a compound represented by the following formula (8), and a compound represented by the following formula (9). 16-. (canceled)8: The production method according to claim 7 , wherein the compound of formula (1) is a ruthenium-carbene complex.9: The production method according to claim 7 , wherein the compound of formula (3) and the compound of formula (4) are reaction products of the compound of formula (1) with the compound of formula (2).10: The production method according to claim 7 , wherein the compound of formula (8) and the compound of formula (9) are reaction products of the compound of formula (3) or the compound of formula (4) with the compound of formula (7).11: The production method according to claim 7 , wherein the compound of formula (2) Xis a fluorine atom and Xis a hydrogen atom claim 7 , a fluorine atom claim 7 , a chlorine atom claim 7 , or a trifluoromethyl group.12: The production method according to claim 11 , wherein the compound of formula (2) is tetrafluoroethylene.13: The production method according to claim 7 , wherein the compound of formula (7) is at least one compound selected from the group consisting of a monosubstituted olefin and a 1 claim 7 ,2-disubstituted olefin.14: The production method according to claim 13 , wherein the monosubstituted olefin and the 1 ...

Подробнее
Номер записи: 86
12-05-2022 дата публикации

PROCESS TO PREPARE SOLUTION FROM HYDROFORMYLATION PROCESS FOR PRECIOUS METAL RECOVERY

Номер: US20220143590A1
Автор: Becker Michael C., Eisenschmid Thomas C., Miller Glenn A.
Принадлежит:

Embodiments of the present invention relate to processes to prepare a spent catalyst fluid from a hydroformylation process for precious metal recovery. In one embodiment, a process comprises (a) removing a spent catalyst fluid from an active hydroformylation reaction system, wherein the spent catalyst fluid comprises the hydroformylation reaction catalyst and is substantially free of non-hydrolyzable triorganophosphorous compounds; and (b) adding a non-hydrolyzable triorganophosphorous compound to the spent catalyst fluid from step (a) prior to storing the fluid or prior to shipping for precious metal recovery. 1. A process to prepare a spent catalyst fluid comprising a hydroformylation reaction catalyst comprising a Group 8 transition metal and a hydrolyzable organophosphorous ligand for precious metal recovery of the Group 8 transition metal , the process comprising:(a) removing a spent catalyst fluid from an active hydroformylation reaction system, wherein the spent catalyst fluid comprises the hydroformylation reaction catalyst and is substantially free of non-hydrolyzable triorganophosphorous compounds; and(b) adding a non-hydrolyzable triorganophosphorous compound to the spent catalyst fluid from step (a) prior to storing the fluid or prior to shipping for precious metal recovery.2. The process of claim 1 , wherein the spent catalyst fluid is concentrated to recover aldehyde product prior to adding the non-hydrolyzable triorganophosphorous compound.3. The process of claim 1 , wherein the non-hydrolyzable triorganophosphorous compound is added to the spent catalyst fluid prior to the spent catalyst fluid being concentrated to recover aldehyde product.4. The process of claim 1 , wherein the spent catalyst fluid comprises 1 to 20 weight percent of the non-hydrolyzable triorganophosphorous compound following step (b).5. The process claim 1 , wherein the non-hydrolyzable triorganophosphorous compound is a triorganophosphine.6. The process of claim 1 , wherein the ...

Подробнее
Номер записи: 87
12-05-2022 дата публикации

Double alkoxycarbonylation of dienes as one-pot synthesis

Номер: US20220144750A1
Автор: JI Yang, Malthias Beller, Ralf Jackstell, Robert Franke
Принадлежит: EVONIK OPERATIONS GMBH

Process for the double alkoxycarbonylation of dienes as one-pot synthesis.

Подробнее
Номер записи: 88
12-05-2022 дата публикации

Method for preparing aromatic amino acid derivative

Номер: US20220144762A1
Автор: Manabu Wadamoto
Принадлежит: Chugai Pharmaceutical Co Ltd

The present invention provides methods of efficiently producing various optically active aromatic amino acid derivatives by reacting, using an additive, a specific ester compound with an aromatic halide and zinc in the presence of a catalyst. The present invention also provides amino acid derivatives that can be produced by the methods.

Подробнее
Номер записи: 89
16-04-2015 дата публикации

Method for converting carbon dioxide and bicarbonates into formic acid derivatives using a cobalt complex as a catalytic system

Номер: US20150105571A1
Автор: Carolin Ziebart, Christopher Federsel, Matthias Beller, Ralf Jackstell
Принадлежит: BAYER TECHNOLOGY SERVICES GMBH

The invention relates to a method for converting carbon dioxide or bicarbonates into formic acid derivatives, i.e. formate salts, formate esters, and formamides, using molecular hydrogen and a catalytic system comprising a cobalt complex of cobalt salt and at least one tripodal, tetradentate ligand. The catalyst complex can be used as a homogeneous catalyst. The invention further relates to the cobalt complexes per se.

Подробнее
Номер записи: 90
26-03-2020 дата публикации

Purified cenicriviroc and purified intermediates for making cenicriviroc

Номер: US20200095229A1
Автор: Morra Nicholas, Phiasivongsa Pasit
Принадлежит:

The disclosure includes high purity compounds having CCR5 and/or CCR2 antagonism, or salts thereof, high purity intermediates thereto and processes for synthesizing the same. 130.-. (canceled)31. A composition of 8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-(2-(1-propyl-1H-imidazol-5-yl)acetyl)phenyl)-1 ,2 ,3 ,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate (Compound I-MsOH) , or an enantiomer , a stereoisomer , or a combination thereof , with a purity of ≥96.0% or ≥98.5% or higher , wherein said compound comprises one or more of the following:(a) about ≤0.50% to about ≥0.30% of 8,8′-(4-(2-butoxyethoxy)-1,3-phenylene)bis(1-isobutyl-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxylic acid) (Compound VIII);(b) about ≤0.50% to about ≥0.30% of 8-(4-(2-butoxyethoxy)phenyl)-1-butyl-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxylic acid (Compound IX);(c) about ≤0.50% to about ≥0.30% of 8-(4-(2-ethoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate (Compound I-MsOH-A);(d) about ≤0.50% to about ≥0.30% of 1-isobutyl-8-(4-(2-propoxyethoxy)phenyl)-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate (Compound I-MsOH-B);(e) about ≤0.50% to about ≥0.45% of 8-(4-butoxyphenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate (Compound I-MsOH-C);(f) about ≤0.50% to about ≥0.45% of 8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)thio)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate (Compound I-MsOH-E);(g) about ≤0.50% to about ≥0.45% of 8-(4-(2-butoxyethoxy)phenyl)-1-butyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate (Compound I-MsOH-F); and(h) about ≤0.50% to about ≥0.45% of 8,8′-(4-(2- ...

Подробнее
Номер записи: 91
13-04-2017 дата публикации

METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN

Номер: US20170101360A1
Автор: TAKAHIRA Yusuke
Принадлежит: Asahi Glass Company, Limited

A method for producing at least one compound selected from the group consisting of a compound represented by the following formula (10), a compound represented by the following formula (11), a compound represented by the following formula (12), and a compound represented by the following formula (13), which the method containing reacting a compound represented by the following formula (2) with a compound represented by the following formula (7), in the presence of at least one compound selected from the group consisting of a compound represented by the following formula (1), a compound represented by the following formula (3), a compound represented by the following formula (4), a compound represented by the following formula (8), and a compound represented by the following formula (9). 15-. (canceled) The present invention relates to a novel method for producing a fluorine-containing olefin through olefin metathesis.Among olefin compounds where a part or all of hydrogen atoms are substituted with fluorine atoms, that is, fluorine-containing olefins, some industrially-useful compounds are known. For example, 1,1,2-trifluoro-2-substituted olefins such as 1,1,2-trifluorostyrene are compounds useful as organic synthetic building blocks, monomers for polymerization, materials for polymer electrolytes, and the like, and 1,1-difluoro-2,2-disubstituted olefins are compounds useful as materials for medicines such as enzyme inhibitors, for ferroelectric materials and the like. However, no method for simply and efficiently producing these compounds has been established yet. For example, Non-Patent Document 1 reports production of 1,1-difluoro-2,2-disubstituted olefins through Wittig reaction of carbonyl compounds (difluoromethylidenation). However, in the case where the carbonyl compound is a ketone, the yield is low even if an excessive amount (4 to 5 equivalents or more) of Wittig reagent is used, and further, as a phosphorus compound, a carcinogenic hexamethylphosphorous ...

Подробнее
Номер записи: 92
04-04-2019 дата публикации

NANO-TO-NANO FE/PPM Pd CATALYSIS OF CROSS-COUPLING REACTIONS IN WATER

Номер: US20190099747A1
Автор: Handa Sachin, Lipshutz Bruce H.
Принадлежит:

In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt. 120.-. (canceled)22. The method of claim 21 , wherein the metal claim 21 , other than Pd claim 21 , is selected from the group consisting of Pt claim 21 , Au claim 21 , Ni claim 21 , Co claim 21 , Cu claim 21 , Mn claim 21 , Rh claim 21 , Ir claim 21 , Ru and Os or a mixture thereof.23. The method of further comprising:iii) contacting the product mixture with an organic solvent to form an organic phase and an aqueous phase; andiv) separating the organic phase from the aqueous phase containing the micelle composition as well as the iron/ppm Pd nanoparticles.24. The method of further comprising:v) re-cycling the aqueous phase containing the micelle composition and Fe/ppm Pd nanoparticles for use in a subsequent cross coupling or other reactions.25. The method of claim 21 , wherein the reaction solvent is water claim 21 , and the reaction solvent further comprising an organic solvent claim 21 , wherein the organic co-solvent is present in at least 5% claim 21 , 10% claim 21 , 20% claim 21 , 30% claim 21 , 40% claim 21 , 50% claim 21 , 70% claim 21 , 80% or at least 90% wt/wt.2611. The method of claim claim 21 , wherein the organic co-solvent is present at a wt of organic co-solvent to the wt of water (wt/wt) of 1/10 claim 21 , 2/10 claim 21 , 5/10 claim 21 , 10/10 claim 21 , 20/10 claim 21 , 30/10 claim 21 , 50/10 claim 21 , 70/10 claim 21 , 90/10 claim 21 , 100/10 claim 21 , 200/10 claim 21 , 300/10 ...

Подробнее
Номер записи: 93
02-06-2022 дата публикации

Catalyst systems

Номер: US20220168715A1
Автор: Motaz Khawaji, Sohel Shaikh, Wei Xu
Принадлежит: Saudi Arabian Oil Co

Catalyst systems suitable for tetramerizing ethylene to form 1-octene may include a catalyst having a structure according to Formula (VI) or Formula (VII). In Formulas (VI) and (VII), X is a halogen, a (C2-C30) carboxylate, acetylacetonate, or a (C1-C30) hydrocarbyl; L1 is a neutral coordinating ligand; n is an integer from 0 to 6; Y is a (C6-C20)fluorine-substituted aryl, a (C6-C20)fluorine-substituted aryloxy, or a (C1-C20)fluorine-substituted alkoxy; and L∩L is a bidentate chelating ligand. The catalyst system may also include an aluminum containing agent which includes a reaction product of an organoaluminum compound and an antifouling compound. The antifouling compound may include one or more quaternary salts.

Подробнее
Номер записи: 94
02-06-2022 дата публикации

Catalyst systems

Номер: US20220168718A1
Автор: Motaz Khawaji, Sohel Shaikh, Wei Xu
Принадлежит: Saudi Arabian Oil Co

Catalyst systems suitable for tetramerizing ethylene to form 1-octene may include a catalyst having a structure according to Formula (VI) or Formula (VII). In Formulas (VI) and (VII), X is a halogen, a (C2-C30) carboxylate, acetylacetonate, or a (C1-C30) hydrocarbyl; L1 is a neutral coordinating ligand; n is an integer from 0 to 6; Y is a (C6-C20)fluorine-substituted aryl, a (C6-C20)fluorine-substituted aryloxy, or a (C1-C20)fluorine-substituted alkoxy; and L∩L is a bidentate chelating ligand. The catalyst system may also include an aluminum containing agent which includes a reaction product of an organoaluminum compound and an antifouling compound. The antifouling compound may include one or more chlorinated hydrocarbons, chloro-aluminum alkyls, or combinations of these.

Подробнее
Номер записи: 95
02-06-2022 дата публикации

CATALYST SYSTEMS

Номер: US20220168719A1
Автор: Khawaji Motaz, Shaikh Sohel, XU WEI
Принадлежит: Saudi Arabian Oil Company

Catalyst systems suitable for tetramerizing ethylene to form 1-octene may include a catalyst having a structure according to Formula (VI) or Formula (VII). In Formulas (VI) and (VII), X is a halogen, a (C-C) carboxylate, acetylacetonate, or a (C-C) hydrocarbyl; Lis a neutral coordinating ligand; n is an integer from 0 to 6; Y is a (C-C)fluorine-substituted aryl, a (C-C)fluorine-substituted aryloxy, or a (C-C)fluorine-substituted alkoxy; and L∩L is a bidentate chelating ligand. The catalyst system may also include an aluminum containing agent which includes a reaction product of an organoaluminum compound and an antifouling compound. The antifouling compound may include one or more polyether alcohols or one or more non-polymeric ethers. 1. A catalyst system suitable for tetramerizing ethylene to form 1-octene , the catalyst system comprising: {'br': None, 'sub': 2', '1', 'n', '4', '2', '1', 'n', '2, 'sup': +', '−', '+', '−, '[(L∩L)CrX(L)][BY]or [(L∩L)CrX(L)][SOY]'}, 'a catalyst having the structure [{'sub': 2', '30', '1', '30, 'X is a halogen, a (C-C) carboxylate, acetylacetonate, or a (C-C) hydrocarbyl;'}, {'sub': '1', 'Lis a neutral coordinating ligand;'}, 'n is an integer from 0 to 6;', {'sub': 6', '20', '6', '20', '1', '20, 'Y is a (C-C)fluorine-substituted aryl, a (C-C)fluorine-substituted aryloxy, or a (C-C)fluorine-substituted alkoxy; and'}, {'br': None, 'sub': 1', '2', '1', '2, '(R)(R)P-Z-P(R)(R)'}, 'L∩L is a bidentate chelating ligand having the structure], 'wherein [{'sub': 1', '2', '1', '50', '6', '50, 'each Rand Ris independently chosen from a (C-C) alkyl group or a (C-C) aryl group; and'}, {'sub': 2', '50', '6', '50', '7, 'Z is a (C-C) alkylene group, a (C-C) arylene group, —N(R)—,'}, {'sub': 7', '7', '7', '2', '7', '1', '50', '6', '50, '—P(R)—, —B(R)—, or —Si(R)— that links the two P atoms, where Ris a (C-C) alkyl group or a (C-C) aryl group; and'}], 'whereinAt least one aluminum containing agent comprising a reaction product of an organoaluminum ...

Подробнее
Номер записи: 96
02-06-2022 дата публикации

CATALYST SYSTEMS

Номер: US20220169583A1
Автор: Khawaji Motaz, Shaikh Sohel, XU WEI
Принадлежит: Saudi Arabian Oil Company

Catalyst systems suitable for tetramerizing ethylene to form 1-octene may include a catalyst including a reaction product of a chromium compound and a ligand having the structure according to Formula (II). In Formula (II), A and C may be independently chosen from phosphorus, arsenic, antimony, bismuth, and nitrogen; B may be a linking group between A and C; and R, R, R, and Rmay be independently chosen from a (C-C) hydrocarbyl or a (C-C) heterohydrocarbyl. The catalyst system may include a co-catalyst including a reaction product of an organoaluminum compound and an antifouling compound. The antifouling compound may include one or more quaternary salts; one or more organic acids, organic acid salts, esters, anhydrides, or combinations of these; one or more chlorinated hydrocarbons, chloro-aluminum alkyls, or combinations of these; one or more polyether alcohols; or one or more non-polymeric ethers. 1. A catalyst system suitable for tetramerizing ethylene to form 1-octene , the catalyst system comprising: [{'br': None, 'sub': 1', '2', '3', '4, '(R)(R)A-B-C(R)(R)'}, A and C are independently chosen from phosphorus, arsenic, antimony, bismuth, and nitrogen;', 'B is a linking group between A and C;', {'sub': 1', '2', '3', '4', '1', '50', '1', '50, 'R, R, R, and Rare independently chosen from a (C-C) hydrocarbyl or a (C-C) heterohydrocarbyl; and'}], 'wherein], 'a catalyst comprising a reaction product of a chromium compound and a ligand having the structure one or more quaternary salts;', 'one or more organic acids, organic acid salts, esters, anhydrides, or combinations of these;', 'one or more chlorinated hydrocarbons, chloro-aluminum alkyls, or combinations of these;', 'one or more polyether alcohols; or', 'one or more non-polymeric ethers., 'a co-catalyst comprising a reaction product of an organoaluminum compound and an antifouling compound, wherein the antifouling compound comprises2. The catalyst system of claim 1 , wherein the antifouling compound comprises one ...

Подробнее
Номер записи: 97
21-04-2016 дата публикации

BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES

Номер: US20160108024A1
Автор: ALCAMÍPERTEJO José, BARRIO FERNÁNDEZ Pablo, CANTERO CAMACHO Ángel, CATALÁN MUÑOZ Silvia, FUSTERO LARDIÉS Santos, GALLEGO SALA José, GONZÁLEZ BULNES Luis, IBAÑEZ SÁNCHEZ Ignacio, PRADO MARTÍN Silvia
Принадлежит:

The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. 18-. (canceled)10. A compound according to selected from2″,3,5,6″-tetrakis(2-aminoethyl)-4″-methoxy-2′,6′-dimethyl-[1,1′:4′,1″-terphenyl]-4-ol2,2′,2″,2′″-(4″-(benzyloxy)-4-methoxy-3′,5′-dimethyl-[1,1′:4′,1″-terphenyl]-2,3″,5″,6-tetrayl)tetraethanamine2″,3,5,6″-tetrakis(2-aminoethyl)-2′-ethyl-4″-methoxy-[1,1′:4′,1″-terphenyl]-4-ol2,2′,2″,2′″-(4″-(benzyloxy)-3′-ethyl-4-methoxy-[1,1′:4′,1″-terphenyl]-2,3″,5″,6-tetrayl)tetraethanamine2″,3,5,6″-tetrakis(2-aminoethyl)-2′,6′-diethyl-4″-methoxy-[1,1′:4′,1″-terphenyl]-4-ol 'or a pharmaceutical salt, ester, solvate, or hydrate thereof.', '2,2′,2″,2′″-(4″-(benzyloxy)-3′,5′-diethyl-4-methoxy-[1,1′:4′,1″-terphenyl]-2,3″,5″,6-tetrayl)tetraethanamine'}11. (canceled)121. A method for the prevention and/or treatment of HIV-1 infection; infections caused by HIV-2 claim 9 , the virus of severe acute respiratory syndrome claim 9 , hepatitis C virus claim 9 , yellow fever virus claim 9 , dengue virus claim 9 , West Nile virus claim 9 , polio virus claim 9 , influenza viruses claim 9 , the Ebola virus claim 9 , human parainfluenza virus claim 9 , rotavirus claim 9 , or by gram-positive and gram-negative bacteria; neuroblastoma claim 9 , prostate cancer claim 9 , ovarian cancer claim 9 , breast cancer claim 9 , head and neck cancer claim 9 , multiple myeloma claim 9 , renal cell cancer claim 9 , Burkitt lymphoma claim 9 , colon cancer claim 9 , hepatocarcinoma; herpes simplex virus infections claim 9 , hypertension claim 9 , psoriasis claim 9 , asthma claim 9 , lupus claim 9 , multiple sclerosis claim 9 , rheumatoid arthritis claim 9 , fibromyalgia claim 9 , epilepsy claim 9 , Alzheimer's disease and Parkinson disease claim 9 , said method comprising administering a therapeutically effective amount of a compound as defined in claim .13. The method according to for the treatment and/or ...

Подробнее
Номер записи: 98
20-04-2017 дата публикации

LIGAND BASED CHROMIUM CATALYST AND APPLICATION IN CATALYZING ETHYLENE OLIGOMERIZATION

Номер: US20170106358A1
Автор: CAO Yucai, Huang Yanfang, Li Jiancheng, LIANG Shengbiao, Liu Rui, Liu Zhenyu, XIAO Shumeng, YE Xiaofeng, ZHONG Xianghong, ZHU HONGPING
Принадлежит:

A ligand based chromium catalyst and application in catalyzing ethylene oligomerization are disclosed. The chromium catalyst is formed by a chromium compound and an organic ligand containing P and/or N. The substituents on N and P of the ligand can be replaced, whereby selective ethylene trimerization and tetramerization can be realized so as to produce 1-hexene and 1-octene at the same time. 2. The chromium catalyst according to claim 1 , wherein the chromium catalyst is formed by a chromium compound and an organic ligand containing P and/or N.3. The chromium catalyst according to claim 1 ,{'sup': 1', '2', '3', '4', '5, 'sub': 1', '10, 'wherein the R, R, R, R, and Rgroups, when being connected with nitrogen atom, are respectively one selected from a group consisting of H, C-Clinear or branched alkyl, heteroalkyl, cycloalkyl, alkenyl, allyl, and substituted phenyl; and'}{'sup': 1', '2', '3', '4', '5, 'sub': 1', '10, 'wherein the R, R, R, R, and Rgroups, when being connected with phosphorus atom, are respectively one selected from a group consisting of C-Clinear or branched alkyl, substituted aryl, and derivatives thereof.'}4. The chromium catalyst according to claim 3 , wherein the R claim 3 , R claim 3 , R claim 3 , R claim 3 , and Rgroups claim 3 , when being connected with nitrogen atom claim 3 , are respectively one selected from a group consisting of H claim 3 , methyl claim 3 , ethyl claim 3 , propyl claim 3 , isopropyl claim 3 , butyl claim 3 , isobutyl claim 3 , tert-butyl claim 3 , pentyl claim 3 , cyclobutyl claim 3 , cyclopentyl claim 3 , cyclohexyl claim 3 , 2-methylcyclohexyl claim 3 , 2 claim 3 ,6-dimethylcyclohexyl claim 3 , adamantly claim 3 , vinyl claim 3 , allyl claim 3 , phenyl claim 3 , naphthyl claim 3 , 2-methylphenyl claim 3 , 2 claim 3 ,4-6-trimethylphenyl claim 3 , 3 claim 3 ,5-dimethylphenyl claim 3 , 3 claim 3 ,5-dimethoxyphenyl claim 3 , 3 claim 3 ,5-di-tert-butylphenyl claim 3 , 2-thienyl claim 3 , 2-furanyl claim 3 , 2-pyridyl claim 3 ...

Подробнее
Номер записи: 99
20-04-2017 дата публикации

NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF

Номер: US20170107251A1
Автор: Balaraman Ekambaram, Gnanaprakasam Boopathy, Gunanathan Chidambaram, Milstein David, Zhang Jing
Принадлежит:

The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes. 4. The process according to claim 1 , wherein Xand/or Xare absent claim 1 , and the pyridyl or bipyridy moiety is unsubstituted.5. The process according to claim 1 , wherein Lis phosphine (PRR).13. The process according to claim 10 , wherein Xand/or Xare absent claim 10 , and the pyridyl or bipyridy moiety is unsubstituted.14. The process according to claim 10 , wherein Lis phosphine (PRR).16. The process of claim 10 , for preparing an amide from amine and an alcohol claim 10 , wherein the process is for preparing a polypeptide or a cyclic dipeptide claim 10 , and wherein the primary or secondary amine and the primary alcohol are a beta-aminoalcohol. This application is a Divisional Application from U.S. application Ser. No. 14/702,641 filed May 1, 2015, which is a Divisional Application from U.S. application Ser. No. 13/880,328 filed Jun. 11, 2013 now U.S. Pat. No. 9,045,381, ...

Подробнее
Номер записи: 100