NOVEL CATALYSTS

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions. 2. The compound of claim 1 , wherein both of Rand Rare tert-butyl claim 1 , cyclohexyl claim 1 , 2-tolyl claim 1 , or 1-adamantyl.3. The compound of claim 2 , wherein both of Rand Rare tert-butyl or 1-adamantyl.4. (canceled)5. (canceled)6. The compound of claim 1 , wherein R claim 1 , R claim 1 , and the nitrogen atom to which they are attached form an optionally substituted 4-10 membered heterocyclic ring.9. The compound of claim 1 , wherein each of Xand Xis C—R claim 1 , and each of Xand Xis C—R claim 1 , wherein each Ris independently selected from —H claim 1 , —CH claim 1 , —OCH claim 1 , halogen claim 1 , or —CF claim 1 , and each Ris independently selected from —H claim 1 , —CH claim 1 , —OCH claim 1 , —N(CH) claim 1 , halogen claim 1 , or —CF; or a vicinal Rgroup and Rgroup together with the carbon atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic or carbocyclic ring.10. The compound of claim 9 , wherein each of X claim 9 , X claim 9 , X claim 9 , and Xis C—H.12. (canceled)13. The compound of claim 11 , wherein R claim 11 , R claim 11 , and the nitrogen atom to which they are attached form an optionally substituted 4-10 membered heterocyclic ring.16. The compound of claim 11 , wherein each of Xand Xis C—R claim 11 , and each of Xand Xis C—R claim 11 , wherein each Ris independently selected from —H claim 11 , —CH claim 11 , —OCH claim 11 , halogen claim 11 , or —CF claim 11 , and each Ris independently selected from —H claim 11 , —CH claim 11 , —OCH claim 11 , —N(CH) claim 11 , halogen claim 11 , or —CF; or a vicinal Rgroup and Rgroup together with the carbon atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic or ...

Novel Compound, Novel Ligand, Novel Transition Metal Complex, and Catalyst Including Novel Transition Metal Complex

The invention provides novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. A ligand of the invention includes a compound represented by General Formula (1): RRRA or General Formula (2): RRA-Y-ARRand having a total of 15 to 110 carbon atoms. In the formulae, A is phosphorus or arsenic; R, R, Rand Rare each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene. 1. A compound represented by General Formula (1) or (2) and having a total of 15 to 110 carbon atoms:{'br': None, 'sup': 1', '2', '3, 'RRRA\u2003\u2003(1)'}{'br': None, 'sup': 1', '2', '3', '4, 'RRA-Y-ARR\u2003\u2003(2)'}{'sup': 1', '2', '3', '4, 'sub': '2-20', '(wherein A is phosphorus or arsenic; R, R, Rand Rare each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene).'}2. The compound according to claim 1 , wherein the electron-withdrawing group is at least one selected from the group consisting of a perhaloalkyl group having 1 to 4 carbon atoms claim 1 , a halogen claim 1 , nitro group claim 1 , cyano group claim 1 , pentafluorophenyl group claim 1 , tetrafluoropyridyl group claim 1 , heptafluorotolyl group claim 1 , 2 claim 1 ,6- ...

WATER-INSOLUBLE RUTHENIUM CATALYST COMPOSITION FOR USE IN AQUEOUS HYDROGENATION REACTIONS

The invention relates to a method for converting a precatalyst complex to an active catalyst complex, wherein the precatalyst complex and the active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, and the active catalyst complex furthermore comprises a monohydride and a water molecule. The method comprises the steps of providing water as an activation solvent system with a pH value equal or below 2, and solving said precatalyst complex, an acid, and hydrogen therein. The invention further relates to a method for manufacturing a catalyst composition, a method for hydrogenating a substrate molecule and a reaction mixture. 1. A method for converting a precatalyst complex to an active catalyst complex ,wherein said precatalyst complex and said active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, andwherein said active catalyst complex comprises a monohydride and a water molecule,said method comprising the steps of:a) providing an activation solvent system comprising water, said precatalyst complex,', 'a solubilizer,', 'an acid, and', 'hydrogen,, 'b) adding to, particularly solving in, said activation solvent system'}characterized in thatthe pH value of said activation solvent system is equal or below 2 after addition of said acid.2. The method according to claim 1 , wherein said activation solvent system comprises ≧50% (v/v) claim 1 , ≧75% (v/v) claim 1 , ≧80% (v/v) claim 1 , ≧90% (v/v) claim 1 , ≧99% (v/v) or 100% water.3. The method according to claim 1 , wherein said solubilizer is a surfactant that is capable of forming micelles in water and that is resistant to hydrolysis at pH≦2.4. A method for obtaining a catalyst composition claim 1 , comprising the steps ofa) providing water as a preparation solvent system, andb) adding to, particularly solving in, said preparation solvent system an optically active ligand, wherein said optically active ligand is ...

BIS(PHOSPHINE)-CARBODICARBENE CATALYST COMPLEXES AND METHODS OF USING THE SAME

An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the structure of Formula (I): The complexes are useful in methods of making an allylic amine carried out by reacting a 1,3-diene with a substituted amine in the presence of such an organometallic complex to produce by intermolecular hydroamination the allylic amine. 1. An organometallic complex , comprising:(a) a tridentate bis(phosphine)-carbodicarbene ligand, and(b) a transition metal.4. The complex of claim 1 , wherein said transition metal is selected from the group consisting of ruthenium claim 1 , nickel claim 1 , palladium claim 1 , platinum claim 1 , rhodium claim 1 , iridium claim 1 , cobalt claim 1 , iron claim 1 , silver claim 1 , gold claim 1 , and molybdenum.5. The complex of claim 2 , wherein R claim 2 , R claim 2 , R claim 2 , and Rare each independently selected alkyl or aryl.6. The complex of claim 2 , wherein at least one R′ is S-L- claim 2 , where S is a solid support and L is a linking group.7. The complex of claim 2 , wherein each R′ is independently hydrogen claim 2 , halo claim 2 , loweralkyl claim 2 , loweralkoxy claim 2 , or hydroxyl.8. A reaction mixture comprising an organometallic complex of claim 1 , a solvent claim 1 , a 1-3 claim 1 , diene substrate claim 1 , and a substituted amine substrate.11. A method of making an allylic amine claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'reacting a 1,3-diene with a substituted amine in the presence of an organometallic complex of in a catalytic amount to produce by intermolecular hydroamination said allylic amine.'}14. A tridentate bis(phosphine)-carbodicarbene pincer ligand. This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/979,749, filed Apr. 15, 2014, the disclosure of which is incorporated by reference herein in its entirety.The present invention concerns carbodicarbene ligands, ...

MONOCARBONYL RUTHENIUM AND OSMIUM CATALYSTS

The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen. 3. The complex of claim 1 , of formula (VII):{'br': None, '[MX(CO)(NN)(PP)]W \u2003\u2003(VII)'}{'sub': 2', '2', '2', '2', '2, 'provided that when X is Cl or H, (NN) is not ethylenediamine or 2-(aminomethyl)pyridine and the diphosphine (PP) is not PhP(CHCHCH)PPh.'}4. The complex of claim 1 , of formula (VIII):{'br': None, 'MXY(CO)(HCNN)(P) \u2003\u2003(VIII).'}5. The complex of claim 1 , of formula (IX):{'br': None, 'MX(CO)(CNN)(P) \u2003\u2003(IX).'}7. The complex of claim 1 , of formula (XI):{'br': None, 'MX(CO)(CP)(HCP) \u2003\u2003(XI)'}{'sup': 23', '21', '22, 'sub': '3', 'provided that when X is Cl and Ris —CH, R-Rare not phenyl.'}8. The complex of claim 1 , of formula (XII):{'br': None, 'MXY(CO)(PP)(P) \u2003\u2003(XII).'}9. The complex of claim 1 , of formula (XIII):{'br': None, 'MXY(CO)(HCN)(PP) \u2003\u2003(XIII).'}10. The complex of claim 1 , of formula (XIV):{'br': None, 'MXY(CO)(PNN) \u2003\u2003(XIV).'}11. The complex of claim 1 , wherein X and Y are the same and are Cl claim 1 , H claim 1 , a C1-C20 alkoxide claim 1 , or a C1-C20 carboxylate.18. A process for preparing a complex of formula (XII) of claim 8 , comprising reacting a compound of formula MXY(CO)(PPh) claim 8 , or formula MXY(CO)(PPh)(dmf) claim 8 , wherein (dmf) is dimethylformamide claim 8 , with a phosphine (P) that is:{'sup': 16', '17', '18', '16', '18, 'a phosphine of formula PRRR, wherein R-Rare each, independently, H, a C1-C20 aliphatic group, or a C5-C20 aromatic group; or'}an optically active phosphine that is (S)-neomenthyldiphenylphosphine or (R)-(+)-2-(diphenylphosphino)-2′-methoxy-1,1′-binaphthyl;or a ...

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

PROCESS FOR THE CATALYTIC REVERSIBLE ALKENE-NITRILE INTERCONVERSION

The present invention refers to processes for catalytic reversible alkene-nitrile interconversion through controllable HCN-free transfer hydrocyanation. 2. Process according to claim 1 , wherein R claim 1 , R claim 1 , Rand Rcan be the same or different and each independently represents H claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl claim 1 , each being optionally substituted by one or more groups selected from straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent claim 1 , or a heterosubstituent claim 1 , or Rand Rform a bond; wherein at least one of R claim 1 , R claim 1 , Rand Ris not hydrogen.3. Process according to claim 1 , wherein R claim 1 , R claim 1 , Rand Rcan be the same or different and each independently represents H claim 1 , straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , each being optionally substituted by one or more groups selected from straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent claim 1 , or a heterosubstituent claim 1 , or at least two of R claim 1 , R claim 1 , Rand Rmay each form a cyclic 3 to 20 membered hydrocarbon ring structure which may further be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , aryl claim 1 , heteroaryl or heterosubstituent claim 1 , and optionally having any of O claim 1 , S claim 1 , N in the straight chain claim 1 , branched chain or cyclic structure claim 1 , wherein optionally at least one of R claim 1 , R claim 1 , Rand Ris not hydrogen.4. Process according to claim 3 , wherein R claim 3 , R claim 3 , Rand Rcan be the same or ...

IMMOBILIZED CATALYTICALLY ACTIVE COMPOSITION FOR HYDROFORMYLATION OF OLEFIN-CONTAINING MIXTURES

A composition and the use of said composition as catalytically active composition in processes for synthesis of chemical compounds, especially the hydroformylation of olefinically unsaturated hydrocarbon mixtures. 1. A composition comprising:a) at least one inert porous support material;b) at least one metal selected from the eighth transition group of the Periodic Table of the Elements;c) at least one organic phosphorus compound; andd) at least one high-boiling liquid on the inert porous support material, having a lower vapour pressure than 0.074 MPa at 100° C. and 1.0 MPa,wherein the composition is free of ionic liquids.2. The composition as claimed in claim 1 , i) mean pore diameter within a range from 1 to 430 nm;', 'ii) pore volume within a range from 0.1 to 2 ml/g; and', {'sup': '2', 'iii) BET surface area within a range from 10 to 2050 m/g.'}], 'wherein the inert porous support material has the following material properties3. The composition as claimed in claim 1 ,wherein the organic phosphorus compounds are phosphines, phosphites and/or phosphoramidites.5. The composition as claimed in claim 1 , wherein the high-boiling liquid is formed in situ during use in a process for chemical synthesis.6. The composition as claimed in claim 5 , wherein the high-boiling liquid is formed in situ during the hydroformylation of olefin-containing hydrocarbon mixtures.7. A process for hydroformylating olefin-containing hydrocarbon mixtures claim 5 , comprising:a) introducing an olefin-containing hydrocarbon mixture into a reaction mixture,b) introducing an inert porous support material into the reaction mixture,c) introducing at least one metal selected from the group consisting of cobalt, rhodium, iridium and ruthenium into the reaction mixture,d) introducing at least one organic phosphorus compound selected from the group consisting of phosphines, phosphites and phosphoramidites into the reaction mixture,e) introducing an aldol compound which is not part of the olefin- ...

PROCESS FOR PRODUCING HETEROCYCLIC COMPOUND

The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate. 2. The method according to claim 1 , wherein the organic metal complex is a transition metal complex.3. The method according to claim 2 , wherein the transition metal complex is a ruthenium complex.4. The method according to claim 3 , wherein the ruthenium complex is represented by the formula:{'br': None, 'sup': 'a', 'sub': '2', '[Ru(OCOR)L*]\u2003\u2003(VIII)'}wherein{'sup': 'a', 'sub': '1-3', 'Ris an optionally substituted Calkyl group; and'}{'sup': 'a', 'Lis a diphosphine ligand.'} This application is a divisional of U.S. application Ser. No. 15/125,299, which is the U.S. National Stage application of PCT/JP2015/057541, filed Mar. 13, 2015, which claims priority from Japanese application 2014-052809, filed Mar. 14, 2014.The present invention relates to a production method of an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative which is useful as a dipeptidylpeptidase inhibitor, and various intermediates useful therefor, and production methods thereof.An optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative is known to be useful as a dipeptidylpeptidase inhibitor and an agent for the treatment of diabetes.Patent Document 1 discloses a method of producing a 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative by reacting optically active 3-aminopiperidine with a 6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative.Patent Document 2 discloses a method of efficiently producing an optically active 8-(3-aminopiperidin-1-yl)xanthine derivative by ...

Catalysts and processes for the hydrogenation of amides

There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.

Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis

Provided herein is a compound of formula (I): 4. The compound of claim 1 , wherein at least one X is OH.5. (canceled)6. The compound of claim 1 , wherein at least one X is PAr.7. (canceled)8. The compound of claim 1 , wherein at least one X is OPAr.9. (canceled)10. The compound of claim 1 , wherein at least one X is P(O)Ar.1112.-. (canceled)13. The compound of claim 6 , wherein Ar comprises phenyl.14. The compound of claim 1 , wherein both X together form OPNR′.1518.-. (canceled)19. The compound of claim 14 , wherein R′ is methyl.2022.-. (canceled)23. The compound of claim 1 , wherein R is ethyl.2428.-. (canceled)29. The compound of claim 1 , wherein at least one R is 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N claim 1 , O claim 1 , and S.3034.-. (canceled)36. A catalyst comprising the compound of formula (I) according to and a transition metal.37. The catalyst of claim 36 , wherein the transition metal comprises iridium claim 36 , palladium claim 36 , rhodium claim 36 , platinum claim 36 , copper claim 36 , nickel claim 36 , cobalt claim 36 , or gold.38. A method of preparing the catalyst of comprising admixing the compound of formula (I) and the transition metal to form the catalyst.39. (canceled)40. The method of claim 38 , wherein the transition metal comprises [Ir(COD)Cl] claim 38 , [Pd(allyl)Cl] claim 38 , or Pd(dba).41. The method of claim 38 , wherein the compound of formula (I) and the transition metal are provided in a molar ratio of about 6:1 to 1:1.42. A method comprising:{'claim-ref': {'@idref': 'CLM-00036', 'claim 36'}, 'admixing a first reactant, a second reactant, and the catalyst of under conditions sufficient to allow reaction of the first reactant and the second reactant to form a reaction product, wherein the reaction product comprises a chiral center and the reaction produces an enantiomeric excess (ee) of the reaction product.'}43. The method of claim 42 , wherein the reaction comprises a hydroarylation ...

Low system memory detection

Methods, systems, and computer readable media may be operable to facilitate an anticipation of an execution of a process termination tool. An allocation stall counter may be queried at a certain frequency, and from the query of the allocation stall counter, a number of allocation stall counter increments occurring over a certain duration of time may be determined. If the number of allocation stall counter increments is greater than a threshold, a determination may be made that system memory is running low and that an execution of a process termination tool is imminent. In response to the determination that system memory is running low, a flag indicating that system memory is running low may be set, and one or more programs, in response to reading the flag, may free memory that is not necessary or required for execution.

INK COMPOSITIONS AND QUANTUM DOT POLYMER COMPOSITE PATTERN PREPARED FROM THE SAME

An ink composition, including a quantum dot; a metal catalyst; an aromatic halide compound; an ene compound including at least one C—H moiety and a carbon-carbon unsaturated bond; and optionally, a metal oxide particle, wherein the metal catalyst is a metal salt, a metal coordination complex, or a combination thereof, wherein the metal catalyst comprises a metal that is palladium, nickel, ruthenium, rhodium, iridium, iron, cobalt, chromium, copper, platinum, silver, gold, or a combination thereof. 1. An ink composition , comprising:a quantum dot;a metal catalyst;an aromatic halide compound;an ene compound comprising at least one C—H moiety and a carbon-carbon unsaturated bond; andoptionally, a metal oxide particle,wherein the metal catalyst comprises a metal salt, a metal coordination complex, or a combination thereof, andwherein the metal catalyst comprises a metal that is palladium, nickel, ruthenium, rhodium, iridium, iron, cobalt, chromium, copper, platinum, silver, gold, or a combination thereof.2. The ink composition of claim 1 , wherein in the ink composition claim 1 , an amount of the metal is less than or equal to about 0.2 moles based on one mole of the ene compound.3. The ink composition of claim 1 , wherein the ink composition has a viscosity of less than or equal to about 20 centipoise claim 1 , or a vapor pressure of less than or equal to about 1.5 mmHg.4. The ink composition of claim 1 , wherein the ink composition has a boiling point of greater than or equal to about 190° C.5. The ink composition of claim 1 , wherein the ink composition exhibits an average particle size of less than or equal to about 2 micrometer as determined by a dynamic light scattering analysis (DLSA).6. The ink composition of claim 1 , wherein the quantum dot is a Group II-VI compound claim 1 , a Group III-V compound claim 1 , a Group IV-VI compound claim 1 , a Group IV element or compound claim 1 , a Group I-III-VI compound claim 1 , a Group II-III-VI compound claim 1 , a Group ...

Monocarbonyl ruthenium and osmium catalysts

The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

Novel ruthenium complex and process for producing optically active alcohol compound using same as catalyst

The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for an asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having a ruthenacycle structure, a catalyst for an asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex.

PROCESS FOR OLIGOMERIZATION

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound. 2. The process of wherein the olefin comprises ethylene and the product comprises a mixture of 1-octene and 1-hexene in a weight fraction ranging from 85 percent by weight to 100 percent by weight of total product formed.3. The process of wherein the catalyst system is prepared by combining a) the source of chromium claim 1 , b) one or more activators claim 1 , and c) at least one phosphacycle-containing ligating compound together in any order.4. The process of comprising contacting a feed stream with the catalyst system wherein the feed stream comprises the olefin.5. The process of claim 1 , wherein the source of chromium is selected from the group consisting of trichlorotris(tetrahydrofuran)chromium claim 1 , chromium (III) acetylacetonate claim 1 , chromium (III) 2-ethylhexanoate claim 1 , and chromium (III) acetate.6. The process of claim 1 , wherein the source of chromium and the ligating compound are contacted in proportions to provide Cr:ligating compound ratios from 1000:1 to 1:1000.7. The process of claim 1 , wherein the catalyst system further includes an activator selected from the group consisting of (hydrocarbyl)aluminum compounds claim 1 , (hydrocarbyl)gallium compounds claim 1 , (hydrocarbyl)boron compounds claim 1 , (hydrocarbyl)zinc compounds claim 1 , non-coordinating claim 1 , ion-forming compounds claim 1 , an organic salt claim 1 , an inorganic acid and salt.8. The process of claim 7 , wherein the activator is an alkylaluminoxane.9. The process of claim 8 , wherein the source of chromium and the aluminoxane are combined in proportions to provide chromium: ...

PINCER-TYPE LIGAND HAVING ACRIDANE STRUCTURE AND METAL COMPLEX USING THE SAME

Disclosed are a pincer-type ligand having a structurally rigid acridane structure and a metal complex consisting of the pincer-type ligand and a metal bound to each other, and exhibiting high reactivity and stability during a variety of bonding activation reactions. T-shaped complexes can be prepared from PNP(4,5-bis(diisopropylphosphino)-2,7,9,9-tetramethyl-9H-acridin-10-ide), which is a pincer-type PNP ligand having an acridane structure, and metal complexes, which can be structurally rigid and thus exhibit excellent reactivity and stability based on minimized structural change thereof, can be prepared by introducing an acridane structure into the backbone thereof. The PNP ligand is structurally stable and has novel chemical properties, as compared to conventional similar ligands, and thus can be utilized in a wide range of catalytic reactions and material chemistry. 3. The metal complex of claim 1 , wherein the metal complex is represented by (PNP)MX claim 1 ,wherein n=0, 1, 2 or 3, andX is ABC, wherein A, B and C are each independently represented by a monodentate ligand or bidentate ligand. This is a divisional under 35 USC § 120 of U.S. patent application Ser. No. 16/260,086 filed Jan. 28, 2019 for “PINCER-TYPE LIGAND HAVING ACRIDANE STRUCTURE AND METAL COMPLEX USING THE SAME”, which in turn claims the priority under 35 USC § 119 of Korean Patent Application 10-2018-0011432 filed Jan. 30, 2018. The disclosures of U.S. patent application Ser. No. 16/260,086 and Korean Patent Application 10-2018-0011432 are hereby incorporated herein by reference, in their respective entireties, for all purposes.The present invention relates a pincer-type ligand having an acridane structure and a metal complex using the same and more particularly, to a pincer-type ligand having a structurally rigid acridane structure and a metal complex consisting of the pincer-type ligand and a metal bound to each other and exhibiting high reactivity and stability during a variety of bonding ...

PROCESS FOR OLIGOMERIZATION

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound. 2. The process of wherein the olefin comprises ethylene and the product comprises a mixture of 1-octene and 1-hexene in a weight fraction ranging from 85 percent by weight to 100 percent by weight of total product formed.3. The process of wherein the catalyst system is prepared by combining a) the source of chromium claim 1 , b) one or more activators claim 1 , and c) at least one phosphacycle-containing ligating compound together in any order.4. The process of comprising contacting a feed stream with the catalyst system wherein the feed stream comprises the olefin.5. The process of claim 1 , wherein the source of chromium is selected from the group consisting of trichlorotris(tetrahydrofuran)chromium claim 1 , chromium (III) acetylacetonate claim 1 , chromium (III) 2-ethylhexanoate claim 1 , and chromium (III) acetate.6. The process of claim 1 , wherein the source of chromium and the ligating compound are contacted in proportions to provide Cr:ligating compound ratios from 1000:1 to 1:1000.7. The process of claim 1 , wherein the catalyst system further includes an activator selected from the group consisting of (hydrocarbyl)aluminum compounds claim 1 , (hydrocarbyl)gallium compounds claim 1 , (hydrocarbyl)boron compounds claim 1 , (hydrocarbyl)zinc compounds claim 1 , non-coordinating claim 1 , ion-forming compounds claim 1 , an organic salt claim 1 , an inorganic acid and salt.8. The process of claim 7 , wherein the activator is an alkylaluminoxane.9. The process of claim 8 , wherein the source of chromium and the aluminoxane are combined in proportions to provide chromium: ...

METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE

The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid. 4. A method according to any one of to , wherein the Lewis acid used in the preparation of the asymmetric catalyst is a Cu(I) Lewis acid or a Cu(II) Lewis acid.5. A method according to any one of to , wherein the Lewis acid used in the preparation of the asymmetric catalyst is a Lewis acid selected from the group consisting of CuOAc , CuCl , CuBr , CuI , CuOTf , CuPF , CuBF , Cu(OAc) , Cu(OTf) , and CuSO.8. A method according to any one of to , wherein the solvent used in the reaction is one or more solvents selected from the group consisting of N ,N-dimethylacetamide , tetrahydrofuran , dimethoxyethane , 2-propanol , toluene , and ethyl acetate.10. A method according to any one of to , wherein Ris a hydrogen atom.11. A method according to any one of to , wherein in formula (I) ,ring Z is a benzene ring optionally having 1 to 4 halogen atoms.12. A method according to any one of to , wherein in formula (II) or formula (V) ,{'sup': '2', 'Ris a pyridyl group optionally having 1 to 4 halogen atoms, or a phenyl group optionally having 1 to 5 halogen atoms.'}13. A method according to any one of to , wherein in formula (II) or formula (V) ,{'sup': 3', '4', '3', '4, 'claim-text': {'sub': 1', '6, 'the cyclopentane ring, the cyclohexane ring, and the tetrahydropyran ring each optionally have 1 to 4 C-Calkyl groups on the ring.'}, 'Rand Reach represent a methyl group, or Rand Rtogether form a ...

CATALYST SYSTEMS FOR USE IN CONTINUOUS FLOW REACTORS AND METHODS OF MANUFACTURE AND USE THEREOF

The present application provides a composite material and system for use in a heterogeneous flow reactor, which can include: a catalytic polymeric framework comprising catalyst-containing monomeric units each separated by at least one non-catalyst-containing monomeric unit; and a solid support material, wherein the catalytic polymeric framework is covalently or non-covalently immobilized on or in the support material. Each catalyst-containing monomeric subunit in the polymeric framework comprises a transition metal bound to a catalyst ligand. Also provided are methods of manufacture and use of the catalyst system and composite material. 133-. (canceled)35. The system of claim 34 , wherein the catalyst-containing monomer subunits comprise a diphosphine ligand.40. The system of claim 39 , wherein A is a binaphthyl group claim 39 , or a derivative of a binaphthyl group claim 39 , each being unsubstituted or substituted with one or more groups independently selected from Calkyl claim 39 , OCalkyl and halo.42. The system of any one of claim 34 , wherein the transition metal is Cr claim 34 , Mo claim 34 , Fe claim 34 , Ru claim 34 , Os claim 34 , Co claim 34 , Rh claim 34 , Ir claim 34 , Ni claim 34 , Pd claim 34 , Pt claim 34 , Cu claim 34 , Ag claim 34 , and/or Au.44. The system claim 34 , wherein the solid support material comprises BaSO claim 34 , barium (L)- and (D)-tartrates claim 34 , aluminum oxide (AlO) claim 34 , silica (SiO) claim 34 , FeO claim 34 , Teflon™ claim 34 , Celite™ claim 34 , AgCl claim 34 , sand claim 34 , or any combination thereof.45. The system of claim 34 , wherein the flow reactor is a continuous flow reactor claim 34 , such as an H-Cube® reactor.46. The system of claim 34 , which additionally comprises means for generating active catalyst.47. The system of claim 46 , wherein the means for generating active catalyst comprises a silver salt claim 46 , such as AgSbF.48. A method for metal-catalyzed organic synthesis comprising flowing a ...

ARYL PHOSPHINES WITH FUSED RING ORTHO-ALKOXY SUBSTITUTION

An aryl phosphine with fused ring ortho-alkoxy substitution that includes an aryl monophosphine and an aryl bi-sphosphme. 2. The aryl phosphine of claim 1 , wherein Rand Rare independently selected from the group consisting of methyl claim 1 , ethyl claim 1 , n-propyl claim 1 , isopropyl claim 1 , n-butyl claim 1 , sec-butyl claim 1 , isobutyl claim 1 , t-butyl claim 1 , adamantyl claim 1 , phenyl claim 1 , biphenyl claim 1 , and cyclohexyl.3. The aryl phosphine of claim 1 , where Rand Rtogether with the phosphorus atom form a 5- claim 1 , 6- claim 1 , or 7-membered ring.10. The aryl phosphine of claim 1 , where the aryl phosphine is a ligand for a transition metal selected from the group consisting of titanium (Ti) claim 1 , copper (Cu) claim 1 , palladium (Pd) claim 1 , cobalt (Co) claim 1 , rhodium (Rh) claim 1 , ruthenium (Ru) claim 1 , chromium (Cr) and platinum (Pt).11. (canceled) This disclosure relates to aryl phosphines with fused ring ortho-alkoxy substitution.Phosphorous (P) containing compounds are ligands for a variety of transition metals, including, but not limited to titanium (Ti), copper (Cu), palladium (Pd), cobalt (Co), rhodium (Rh), ruthenium (Ru), chromium (Cr) and platinum (Pt). In particular, P containing compounds, such as aryl phosphines, which include a P atom covalently bonded to an aryl ring, are ligands for a variety of transition metal catalyzed reactions. These transition metal catalyzed reactions can include hydrogenations, ethylene carbon monoxide copolymerizations, butadiene telomerization, hydroformylation, metal (e.g., Pd) catalyzed cross coupling (e.g., Suzuki reactions, Buchwald-Hartwig coupling reactions), methoxycarbonylation of olefins, ethylene oligomerization, and olefin polymerization.When an aryl phosphine is used as a ligand for one of these transition metal catalyzed reactions, the electronic and steric environment around the transition metal catalyst can be changed by varying the substituents on the aryl ring of the ...

Method for producing a spirooxindole derivative

The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE

The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid. 4. A method according to any one of to , wherein the Lewis acid used in the preparation of the asymmetric catalyst is a Cu(I) Lewis acid or a Cu(II) Lewis acid.5. A method according to any one of to , wherein the Lewis acid used in the preparation of the asymmetric catalyst is a Lewis acid selected from the group consisting of CuOAc , CuCl , CuBr , CuI , CuOTf , CuPF , CuBF , Cu(OAc) , Cu(OTf) , and CuSO.8. A method according to any one of to , wherein the solvent used in the reaction is one or more solvents selected from the group consisting of N ,N-dimethylacetamide , tetrahydrofuran , dimethoxyethane , 2-propanol , toluene , and ethyl acetate.10. A method according to any one of to , wherein Ris a hydrogen atom.11. A method according to any one of to , wherein in formula (I) ,ring Z is a benzene ring optionally having 1 to 4 halogen atoms.12. A method according to any one of to , wherein in formula (II) or formula (V) ,{'sup': '2', 'Ris a pyridyl group optionally having 1 to 4 halogen atoms, or a phenyl group optionally having 1 to 5 halogen atoms.'}13. A method according to any one of to , wherein in formula (II) or formula (V) ,{'sup': 3', '4', '3', '4, 'claim-text': {'sub': 1', '6, 'the cyclopentane ring, the cyclohexane ring, and the tetrahydropyran ring each optionally have 1 to 4 C-Calkyl groups on the ring.'}, 'Rand Reach represent a methyl group, or Rand Rtogether form a ...

PROCESS FOR PRODUCTION OF D-SORBITOL

The present invention relates to a new process for the production of D-sorbitol. 2. A process according to claim 1 , wherein the transition metal of the transition metal based complex is selected from the group consisting of Ru claim 1 , Ir claim 1 , Pd claim 1 , Pt claim 1 , Rh claim 1 , Fe claim 1 , Os claim 1 , Ni claim 1 , and Co.3. A process according to claim 2 , wherein the transition metal of the transition metal based complex is selected from the group consisting of Ru and Ir.4. A process according to claim 1 , wherein the transition metal based complex comprises at least one organic ligand.6. A process according to claim 1 , wherein the process is carried out in at least one solvent.7. A process according to claim 6 , wherein the process is carried out in at least one non-aqueous claim 6 , organic or polar solvent.8. A process according to claim 1 , wherein the process is carried out in the presence of Hgas.9. A process according to claim 1 , wherein the process is carried out at a pressure of about 2 bar to about 200 bar claim 1 , preferably of about 5 bar to about 100 bar claim 1 , more preferably of about 10 bar to about 60 bar.10. A process according to claim 1 , which is carried out at a temperature in the range from about 20° C. to about 150° C. claim 1 , preferably from about 30° C. to about 100° C.11. A process according to claim 1 , which is carried out at a molar ratio of substrate to catalyst in the range of about 50 to about 100000 claim 1 , preferably of about 100 to about 40000 claim 1 , more preferably of about 5000 to about 30000.12. A process according to claim 1 , wherein the process is carried out in the presence of at least one base claim 1 , preferably at least one alkoxide base. The present invention relates to a new process for the production of sorbitol.D-Sorbitol, also known as D-glucitol, is a sugar alcohol with a sweet taste which the human body metabolizes slowly.D-Sorbitol, which IUPAC name is (2S,3R,4R,5R)-hexane-1,2,3,4,5,6- ...

PROCESS FOR PREPARING AN UNSATURATED CARBOXYLIC ACID SALT

Catalytic process for preparing an α,β-ethylenically unsaturated carboxylic acid salt, comprising reacting an alkene and carbon dioxide in the presence of a carboxylation catalyst and releasing the α,β-ethylenically unsaturated carboxylic acid salt with a base, the carboxylation catalyst being a transition metal complex, which comprises a structurally constrained bidentate P,X ligand, wherein X is selected from the group consisting of P, N, O, and carbene, the P and X atom are separated by 2 to 4 bridging atoms, and wherein the bridging atoms are part of at least one 5- to 7-membered cyclic substructure. A further catalytic processes for preparing α-βethylenically unsaturated carboxylic acid derivatives from COand an alkene is provided. 1: A catalytic process for preparing an α ,β-ethylenically unsaturated carboxylic acid salt , the process comprising reacting an alkene and carbon dioxide in the presence of a carboxylation catalyst and releasing the α ,β-ethylenically unsaturated carboxylic acid salt with a base ,wherein:the carboxylation catalyst is a transition metal complex comprising a structurally constrained bidentate P,X ligand:X is selected from the group consisting of P, N, O, and a carbene;the P and X atoms of the P,X ligand are separated by 2 to 4 bridging atoms; andthe bridging atoms are contained in at least one 5- to 7-membered cyclic substructure.2: The catalytic process according to claim 1 , wherein the structurally constrained bidentate ligand is a P claim 1 ,X ligand is a P claim 1 ,P ligand in which:each bridging atom is directly linked to a P atom, together with the P atom to which it is linked, and the bridging atoms are contained in a 5 to 7-membered cyclic substructure; ortwo neighboring bridging stomas are contained in a 5- to 7-membered cyclic substructure.4: The catalytic process according to claim 3 , wherein:the structurally constrained bidentate P,X ligand is a ligand of formula (IIa); and{'sup': 6', '7, 'sub': '3', 'Ris CR.'}6: The ...

CHROMIUM COMPLEX AND CATALYST THEREFROM

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound. 110-. (canceled)121. The catalyst system as in claim comprising a phosphacycle-containing ligating compound-chromium complex.131. The catalyst system as in claim comprising an isolated phosphacycle-containing ligating compound-chromium complex.141. The catalyst system as in claim comprising an in situ-formed phosphacycle-containing ligating compound-chromium complex.151. The catalyst system of claim , wherein the source of chromium is selected from the group consisting of trichlorotris(tetrahydrofuran)chromium , chromium (III) acetylacetonate , chromium (III) 2-ethylhexanoate , and chromium (III) acetate.161. The catalyst system of claim , wherein the source of chromium and the ligating compound are contacted in proportions to provide Cr:ligating compound ratios from 1000:1 to 1:1000.171. The catalyst system of claim , wherein at least one activator is selected from the group consisting of (hydrocarbyl)aluminum compounds , (hydrocarbyl)gallium compounds , (hydrocarbyl)boron compounds , (hydrocarbyl)zinc compounds , non-coordinating , ion-forming compounds , an organic salt , an inorganic acid and salt , Brønsted acid salts , salts of a cationic oxidizing agent and a non-coordinating , compatible anion , carbenium salts , and silylium salts.181. The catalyst system of claim , wherein the activator is an alkylaluminoxane.191. The catalyst system of claim , wherein the source of chromium and the aluminoxane are combined in proportions to provide chromium:activator molar ratios from 1:1 to 1:10 ,000. This application is a Divisional of U.S. National Stage application Ser. No. 15/ ...

Process for the Preparation of Olaparib and Intermediates Thereof

The present invention provides processes for the preparation of intermediate compounds of formulas (4) and (5) useful in the preparation of Olaparib. 2. The process of wherein the reaction of the compound of Formula (4) with hydrazine occurs in the presence of a metal hydroxide base.4. The process of wherein X is bromide.5. The process of wherein the alkali metal alkoxide is sodium methoxide claim 4 , sodium ethoxide or mixtures thereof.6. The process of wherein the compound of formula RCOR′ is selected from the group consisting of methyl formate claim 5 , ethyl acetate claim 5 , isopropyl acetate claim 5 , methyl propionate claim 5 , ethyl propionate claim 5 , ethyl butyrate and mixtures thereof.7. The process of wherein the compound of formula RCOR′ is ethyl propionate.10. The process of wherein the reaction of step (a) occurs in the presence of a metal hydroxide base.13. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium.14. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium and the ligand is Xantphos.16. The process of wherein X is bromide.17. The process of wherein the reaction of step (i) occurs in the presence of a metal hydroxide base.19. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium.20. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium and the ligand is Xantphos. This application claims priority to U.S. Provisional Patent Application No. 62/294,366 filed Feb. 12, 2016, the disclosure of which is hereby incorporated in its entirety by reference.The present invention relates to the field of synthesis of organic compounds and, in particular, to the synthesis of intermediates useful in the preparation of Olaparib.Olaparib (4-[(3-{([4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorophenyl)methyl]phthalazin-1(2H)one), is indicated for the treatment of germline BRCA-mutated advanced ovarian ...

Pincer-type ligand having acridane structure and metal complex using the same

Disclosed are a pincer-type ligand having a structurally rigid acridane structure and a metal complex consisting of the pincer-type ligand and a metal bound to each other, and exhibiting high reactivity and stability during a variety of bonding activation reactions. T-shaped complexes can be prepared from acri PNP(4,5-bis(diisopropylphosphino)-2,7,9,9-tetramethyl-9H-acrid in-10-ide), which is a pincer-type PNP ligand having an acridane structure, and metal complexes, which can be structurally rigid and thus exhibit excellent reactivity and stability based on minimized structural change thereof, can be prepared by introducing an acridane structure into the backbone thereof. The PNP ligand is structurally stable and has novel chemical properties, as compared to conventional similar ligands, and thus can be utilized in a wide range of catalytic reactions and material chemistry.

Selective catalysts for spinetoram production

This invention is based on the discovery that homogeneous catalysts, [Rh(C 2 H 4 ) 2 Cl] 2 and/or [Rh(COD) 2 ][BF 4 ], can be used to produce spinetoram in higher yields at lower catalyst loadings as compared to previous methodologies. In addition, one or more phosphorus ligand donors can also be added to further increase yields/efficiency. The methods and/or systems provided herein enable cost-effective ways to produce spinetoram in large quantity with relatively simple procedures.

METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF

The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound 2. Method according to claim 1 , wherein R is methyl or cyclohexyl.3. Method according to claim 1 , wherein the mixture comprises either the compound according to Formula (X1) or the compound according to Formula (X2) in excess and wherein the hydrogenation step is an asymmetric hydrogenation step in the presence of a catalyst.4. Method according to claim 3 , wherein the compound according to Formula (X1) is present in the mixture in an enantiomeric excess of at least 10% claim 3 , preferably at least 20% claim 3 , more preferably at least 30% claim 3 , at least 40% claim 3 , at least 50% claim 3 , at least 60 claim 3 , at least 70% claim 3 , most preferably at least 80%.5. Method according to claim 3 , wherein the catalyst is an iridium based catalyst.6. Method according to claim 5 , wherein the catalyst comprises an iridium compound in combination with a chiral phosphine ligand.8. Method according to claim 3 , wherein the asymmetric hydrogenation step in the presence of a catalyst is carried out involving at least one of:elevated temperature, which temperature is preferably at least 60° C., for instance at least 80° C., at least 90° C. or at least 100° C.;a solvent selected from dioxane, THF, Me-THF, IPA, DCE, DCM, ethyl acetate, toluene, α,α,α-trifluorotoluene, xylene, preferably m-xylene or p-xylene, mesitylene or a mixture of any two or more thereof;{'sub': 2', '3', '4', '4, 'at least one additive, which is preferably selected from iodine (I), iodide, phosphoric acid (HPO), acetic acid (AcOH), HI, HBF, preferably in an amount of at least 5 mol %, more preferably at least 50 mol %, more preferably at least 100 mol %;'}a substrate concentration of at least 0.05 mmol/l, for instance at least 10 mmol/l, at least 100 mmol/l;a catalyst ...

METAL-CATALYZED ALKOXYCARBONYLATION OF A LACTONE

The metal-catalyzed alkoxycarbonylation of a lactone is a method of alkoxycarbonylating a δ-lactone, specifically 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one. The method includes combining the δ-lactone with an alcohol in an organic solvent in the presence of a catalyst system that includes palladium or a salt thereof to form a reaction mixture, which is heated to 110-130° C. at a pressure of 20-50 bar for between 3-5 hours under flow of carbon monoxide gas. The product of the reaction is a substituted 2-octendioate diester. The alcohol may be methyl alcohol, n-butyl alcohol, 2-ethylhexanol, isobutyl alcohol, isopropyl alcohol, benzyl alcohol, or phenol. The solvent may be toluene, acetonitrile, or tetrahydrofuran. The method may include adding an acid to the reaction mixture, which may be dilute (about 5 mol %) sulfuric or p-toluenesulfonic acid. The catalyst system may also include a phosphine ligand. 1. A method for metal-catalyzed alkoxycarbonylation of a δ-lactone , the δ-lactone being 3-ethylidene-6-vinyletetrahydro-2H-pyran-2-one , the method comprising the steps of:adding an alcohol and a catalyst system including palladium or a salt thereof to a solution of the δ-lactone in an organic solvent to form a reaction mixture;placing the reaction mixture under pressure of carbon monoxide (CO) gas;heating the reaction mixture to a temperature of at least 110° C.; andrecovering a 2-octendioate diester product.2. The method for metal-catalyzed alkoxycarbonylation according to claim 1 , wherein the catalyst system further comprises a phosphine ligand.3. The method for metal-catalyzed alkoxycarbonylation according to claim 2 , wherein the phosphine ligand is selected from the group of phosphine ligands having the formulas shown in L1 claim 2 , L2 claim 2 , L3 claim 2 , L4 claim 2 , L5 claim 2 , L6 claim 2 , L7 claim 2 , L8 claim 2 , L9 claim 2 , L10 claim 2 , L11 claim 2 , L12 claim 2 , L13 claim 2 , L14 claim 2 , L15 claim 2 , L16 claim 2 , L17 claim 2 , L18 claim 2 ...

Oxidative Dehydroxymethylation of Alcohols to Produce Olefins

Catalyst compositions for the conversion of aldehyde compounds and primary alcohol compounds to olefins are disclosed herein. Reactions include oxidative dehydroxymethylation processes and oxidative dehydroformylation methods, which are beneficially conducted in the presence of a sacrificial acceptor of Hgas, such as N,N-dimethylacrylamide. 1. A catalyst composition comprising:a Group VIII metal compound;(ii) a heteroatomic ligand compound;(iii) a Bronsted acid compound; and(iv) an acceptor comprising an α,β-unsaturated compound.2. The catalyst composition of claim 1 , wherein the acceptor comprises an α claim 1 ,β-unsaturated ketone claim 1 , an α claim 1 ,β-unsaturated amide claim 1 , an α claim 1 ,β-unsaturated thioester claim 1 , or any combination thereof.3. The catalyst composition of claim 1 , wherein the acceptor comprises methyl vinyl ketone claim 1 , acrylonitrile claim 1 , ethyl acrylate claim 1 , t-butyl acrylate claim 1 , acrylamide claim 1 , dimethylacrylamide claim 1 , or any combination thereof.4. The catalyst composition of claim 1 , wherein the acceptor comprises dimethylacrylamide.5. The catalyst composition of claim 1 , wherein:{'sub': '2', 'the acceptor is capable of being reduced by an equivalent of H; and'}the acceptor is capable of coordinating to the metal compound.6. The catalyst composition of claim 1 , wherein:the metal compound comprises a rhodium compound, a cobalt compound, an iridium compound, or a combination thereof;the heteroatomic ligand compound comprises a phosphine donor group, an amine donor group, a sulfide donor group, or any combination thereof; andthe Bronsted acid compound is a carboxylic acid.7. The catalyst composition of claim 1 , wherein:{'sub': '2', 'the metal compound is [Rh(cod)OMe];'}the heteroatomic ligand compound is Xantphos; andthe Bronsted acid compound is 3-methoxybenzoic acid.8. The catalyst composition of claim 1 , wherein:a molar ratio of the metal compound to the heteroatomic ligand compound is in a ...

PROCESS FOR PREPARING A NOVEL PHENICOL ANTIBACTERIAL AGENT

The present invention provides a novel process for preparing a diastereomeric mixture of the phenicol of Formula (1), its use for the treatment of bacterial infections in animals, and veterinary compositions containing the Formula (1) compound, diastereomers thereof, and veterinary acceptable salts thereof. 2. The process of comprising the steps of:{'sub': 2', '2', '2', '3', '2', '3', '3', '3, 'a) pre-activating the Formula (B) compound with a palladium catalyst selected from the group consisting of Pd(OAc), PdCl, Pd-G2-XPhos, Pd-XPhos Crotyl Cl, Pd(dppf)Cl, Pd-G2-PCy, and Pd(dba), in the presence of an alcohol, a ligand selected from the group consisting of XPhos, SPhos, dppp, dppf, dba, PPh, and PCy, and a borylation buffer that comprises an acid and a base, wherein said acid is selected from the group consisting of HOAc, citric acid, formic acid, chloroacetic acid, and ammonium acetate;'}{'sub': 2', '2', '2', '2', '4, 'b) borylating the preactivated Formula (B) compound of step (a) by adding a borylating agent in an alcohol; wherein the borylating agent is selected from the group consisting of bisboronic acid, bisboronic acid and ethylene glycol, bisboronic acid and propylene glycol, BPin, and B(NMe);'}c) mixing the Formula (A) compound with a base in an alcohol, co-solvent, or mixtures thereof; andd) mixing the reactants of Step (c) to the reactants of Step (b) to give the compound of Formula (1), and diastereomers thereof.3. The process of claim 1 , wherein the base in Step (a) and (c) is selected from the group consisting of KOAc claim 1 , CsOAc claim 1 , TEA claim 1 , KCO claim 1 , NaCO claim 1 , CsCO claim 1 , DIPEA claim 1 , and KPO claim 1 , and mixtures thereof; and wherein the alcohol in Steps (a) claim 1 , (b) claim 1 , and (c) is selected from the group consisting of methanol claim 1 , ethanol claim 1 , 1-propanol claim 1 , 2-propanol and 2-butanol.4. The process of claim 3 , wherein the alcohol in Steps (a) and (b) is anhydrous ethanol and the alcohol ...

PROCESS FOR HYDROFORMYLATION OF PENTENOIC ESTERS

Process comprising the process steps of: 2. Process according to claim 1 , wherein the conversion is effected at a temperature of 80° C. to 130° C. and a pressure of 1 to 20 bar.3. Process according to claim 1 , wherein the conversion is effected at a temperature of 90° C. to 120° C. and a pressure of 1 to 15 bar.4. Process according to claim 1 , wherein the metal in process step b) is Rh.6. Process according to claim 5 , wherein the conversion is effected in one phase.8. Process according to claim 7 , wherein the conversion is effected in a two-phase system. The invention relates to a process for hydroformylation of pentenoic esters.The synthesis of 5-formylpentanoic esters (5-FMP) and of mixtures with the branched aldehydes has often been an object of study for some time now.U.S. Pat. No. 5,264,616 introduces the use of rhodium complexes with bidentate phosphite ligands. The reaction conditions are 100° C. and 5 bar of synthesis gas. The phosphite ligand with the best performance herein afforded the desired 5-FMP at a conversion of 95.5% with a selectivity of 76.7% after 5 h.WO95/18089 describes a diphosphite-modified Rh-carbonyl complex. At 90° C. and 10 bar of synthesis gas pressure the best ligand in 27 h afforded a conversion of 54.2% of 5-FMP with a selectivity of 80.4%.U.S. Pat. No. 6,664,427B1 describes experiments with bidentate phosphoramidites. Employed here, inter alia, was a salicylanilide-based phosphoramidite having a BINOL backbone. The hydroformylation was performed at 100° C. at 10 bar of synthesis gas and afforded 5-FMP with a selectivity of 84.8% and a conversion of 80.3%.U.S. Pat. No. 6,017,843 likewise describes a hydroformylation reaction. The ligand employed here at 100° C. and 6 bar of synthesis gas affords 5-FMP with 78% n-selectivity at 82% conversion.WO2014/111446A1 describes a 2-phase catalysis with toluene/HO (1:1) as the solvent system. To increase the water solubility of the catalyst, TPPTS ligands were employed. Thus at 100° C. and ...

Phosphacycle compound and process for production thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

CATALYST, HYDROGENATION OF HYDROGEN CARBONATE, HYDROGEN STORAGE SYSTEM

The invention relates to a catalyst according to the formula IrCl(cod)(NHC)]+nP (n=2, 3 or 4), or [Ir(cod)(NHC)(P)]+nP (n=1, 2 or 3), which is suitable to decompose formates in an aqueous reaction system, and for the production of hydrogen gas free of COor hydrogenation of hydrogen carbonates, wherein Ir means iridium; Cl means chloro; cod means 1,5-cyclooctadiene; NHC means N-heterocyclic carbene, preferably 1-R-3-methylimidasolium chloride, wherein R means C1 to C5 alkyl and P means 1,3,5-triaza-7-phosphaadamantane (pta), monosulphonated triphenilphosphine (mtppms), trisulphonated triphenylphosphine (mtppts), or tetrasulphonated diphenylphosphynopropane (dpppts). Furthermore, the invention relates to a process for the preparation of the catalyst according to the invention. Further, the invention relates to a process for the decomposition of formate in aqueous reaction system, and for the production of hydrogen gas free of CO, still further, a process for the hydrogenation of hydrogen carbonate in an aqueous reaction system, as well as the production of the respective formate. Further, the invention relates to a process for the decomposition of formate according to the invention, and the hydrogenation of the hydrogen carbonate generated in the same reaction system. The invention relates to a hydrogen storage system based on the process according to the invention, preferably accumulator or fuel cell, and the use thereof. 1. A catalyst according to the general formula of [IrCl(cod)(NHC)]+nP , which is suitable for the decomposition of formates in an aqueous reaction system and for the generation of hydrogen gas (H) , which is free of COside products , or for the hydrogenation of hydrogen carbonates (HCO) , wherein in the formulaIr means iridium;Cl means chloro;cod means 1,5-cyclooctadiene;NHC means an N-heterocyclic carbene, preferably 1-R-3-methylimidazolium chloride, wherein R means C1 to C5 alkyl group, preferably C2 or C4 alkyl group;n means an integer with the ...

CATALYST SYSTEM

The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: 137-. (canceled)38. A process for the carbonylation of an ethylenically unsaturated compound comprising an ethylenically unsaturated compound with carbon monoxide and a hydroxyl group containing compound in the presence of a catalyst system , which system is obtained by combining:a) a metal of Group VIB or Group VIIIB or a compound thereof,b) a bidentate phosphine, arsine, or stibine ligand, andc) an acid,wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and said acid is present in at least a 2:1 molar excess compared to said ligand.39. A process as claimed in wherein the ratio of said ligand to said metal is in the range 5:1 to 750:1.40. A process as claimed in wherein the ratio of said ligand to said metal is in the range 10:1 to 500:1.41. A process as claimed in wherein the ratio of said ligand to said metal is in the range 20:1 to 40:1.42. A process as claimed in wherein the ratio of said acid to said ligand is in the range 20:1 to 40:1.43. A process as claimed in wherein the molar ratio of said acid to said metal is in the range 10:1 to 75000:1.44. A process as claimed in wherein the molar ratio of said acid to said metal is in the range 100:1 to 25000:1.45. A process as claimed in wherein the molar ratio of said acid to said metal is in the range 200:1 to 400:1.46. A process as claimed in wherein said ligand is a bidentate phosphine ligand.48. A process as claimed in wherein Rto Reach independently represent lower alkyl claim 47 , aryl claim 47 , or Het.49. A process as claimed in wherein said ligand is represented as:{'br': None, 'sub': S', 'T', 'u', 'v, 'sup': 7', '8', '9', '2', '1', '1', '2', '3, '(Ad)(CRRR)Q-A-(K,D)Ar(E,Z)—B-Q(Ad)(CRRR),'}{'sup': 3', '13', '14', '15, 'sub': w', 'x, 'wherein K, D, E and Z may ...

METHOD FOR PRODUCING A SPIROOXINDOLE DERIVATIVE

The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid. 3. The method of claim 2 , wherein the Lewis acid is a Cu(I) Lewis acid or a Cu(II) Lewis acid.4. The method of claim 2 , wherein the Lewis acid is selected from the group consisting of CuOAc claim 2 , CuCl claim 2 , CuBr claim 2 , CuI claim 2 , CuOTf claim 2 , CuPF claim 2 , CuBF claim 2 , Cu(OAc) claim 2 , Cu(OTf) claim 2 , and CuSO.5. The method of claim 2 , whereinthe chiral ligand selected from the group consisting of a compound of formula (VI), a compound of formula (VII), a compound of formula (VIII), a compound of formula (IX), a compound of formula (X), a compound of formula (XI), and a compound of formula (XII),{'sup': '6', 'Ris a phenyl group optionally substituted with 1 to 3 substituents independently selected from the group consisting of a methyl group, a t-butyl group, and a methoxy group,'}ring Y is a benzene ring, a cyclohexane ring, or a dioxolane ring,{'sup': '7', 'Ris a phenyl group or a furanyl group, wherein'}the phenyl group and the furanyl group are each optionally substituted with 1 to 3 substituents independently selected from the group consisting of a methyl group, a t-butyl group, and a methoxy group,{'sup': '8', 'Ris a hydrogen atom or a methoxy group,'}{'sup': '9', 'Ris a methoxy group, or,'}{'sup': '9', 'two Rmoieties together form a 9-membered heterocyclic ring containing two oxygen atoms in the ring,'}{'sup': '10', 'Ris a methoxy group,'}{'sup': '11', 'sub': '2', 'V is P(R),'}{'sup': ' ...

PROCESS FOR THE TRANSITION METAL CATALYZED CYANATION OF ARYL/VINYL HALIDES

The present invention refers to a process for a transition metal, particularly nickel-catalyzed cyanation reaction of aryl/vinyl halide using organic nitrile compounds. This new reaction provides a strategically distinct approach to the safe preparation of aryl/vinyl cyanides, which are essential compounds in agrochemistry and medicinal chemistry. 2. Process according to wherein Rrepresents a Cto Chydrocarbon chain which forms a five to eight-membered optionally substituted hydrocarbon ring system with the vinyl moiety which ring system may be a cycloalkyl claim 1 , heterocycloalkyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl or heteroaralkyl hydrocarbon claim 1 , which may be part of a hydrocarbon ring system having up to 30 carbon atoms and which may optionally be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent.3. Process according to wherein Rrepresents a Cto Chydrocarbon chain which forms a five to six membered optionally substituted aromatic or heteroaromatic hydrocarbon ring system with the vinyl moiety claim 1 , which may be part of a hydrocarbon ring system having up to 30 carbon atoms and which may optionally be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent.4. Process according to wherein Ris a Rrepresents a straight chain Cto Calkyl group.5. Process according to claim 1 , wherein the coordinated transition metal catalyst is obtained from a transition metal catalyst precursor selected from Ni(COD) claim 1 , Ni(acac) claim 1 , Ni(CO) claim 1 , Pd(dba) claim 1 , Pd(OAc) claim 1 , Co(CO).6. Process according to wherein the ligand of the coordinated transition metal catalyst ...

WATER-INSOLUBLE RUTHENIUM CATALYST COMPOSITION FOR USE IN AQUEOUS HYDROGENATION REACTIONS

The invention relates to a method for converting a precatalyst complex to an active catalyst complex, wherein the precatalyst complex and the active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, and the active catalyst complex furthermore comprises a monohydride and a water molecule. The method comprises the steps of providing water as an activation solvent system with a pH value equal or below 2, and solving said precatalyst complex, an acid, and hydrogen therein. The invention further relates to a method for manufacturing a catalyst composition, a method for hydrogenating a substrate molecule and a reaction mixture. 1. A method for obtaining a catalyst composition , comprising the steps ofa) providing water as a preparation solvent system, and a first catalyst composition comprising an optically inactive ligand and a ruthenium metal atom,', 'an optically active ligand, wherein said optically active ligand is insoluble in water,', 'a preparation surfactant that is capable of forming micelles in water and that is resistant to hydrolysis at pH≦2, and', 'an acid,', 'thereby yielding a second catalyst composition comprising said ruthenium atom and said optically active ligand,, 'b) adding to, particularly solving in, said preparation solvent system'}characterized in thatthe pH value of said preparation solvent system is equal or below 2 after addition of said acid.2. The method according to claim 1 , wherein said preparation solvent system comprises ≧25% (v/v) claim 1 , ≧50% (v/v) claim 1 , ≧75% (v/v) claim 1 , ≧80% (v/v) claim 1 , ≧90% (v/v) claim 1 , ≧99% (v/v) or 100% water.3. The method according to claim 1 , wherein said preparation surfactant is non-ionic claim 1 , particularly an alkylglycoside.4. The method according to claim 1 , wherein said preparation surfactant is D-glycopyranoside C9-C11 alkyl.7. The method according to wherein said reaction surfactant is non-ionic surfactant claim 6 , particularly an ...

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Olefin oligomerization process with a catalyst comprising a chromium complex with a phosphacycle-containing ligand

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound.

Ruthenium-phosphine complexes

A ruthenium-phosphine complex is of formula [RUX ℓ (L) m (R-BINAP)]Y n       (I) wherein R-BINAP represents a tertiary phosphine represented by wherein R represents a hydrogen atom or a methyl group; X represents a halogen atom; L represents substituted or unsubstituted benzene or acetonitrile; Y represents a halogen atom, ClO₄, PF₆, BPh₄ (wherein Ph represents a phenyl group) or BF₄; when L is substituted or unsubstituted benzene, ℓ represents 1, m represents 1, and n represents 1; and when L is acetonitrile, when ℓ is 1, then m represents 2, and n represents 1, and when ℓ is 0, then m represents 4, and n represents 2. 27 specific complexes are shown. Synthesis is by (a) RuCl₂(Ar) + BINAP in a solvent at 25 to 50°C; (b) [RuCl₂ (Ar)]₂ + Br or I salt of Li, Na or K, in water or in a mixture of water and methylene chloride and in pre­sence of a quaternary ammonium or phosphonium halide; (c) [RuCl(Ar) BINAP]Cl + a Na, K, Li, Mg or Ag salt (MY); of ClO₄, PF₆ BPh₄ or BF ₄ , in an organic solvent; or (d) [RuCl(Ar) BINAP]Cl in an organic solvent, optionally with MY is heated at 25°C-50°C for 10-24 hours. The complex is used as catalyst in asymmetric hydrogenation, e.g. of methyl acetoacetate, and exhibits excellent catalytic activity to provide a product of high optical purity.

Process for the carbonylation of ethylenically unsaturated compouds

A process for the carbonylation of ethylenically unsaturated compounds is described. The process comprises reacting an ethylenically unsaturated compound with carbon monoxide in the presence of a source of hydroxyl groups and a catalyst system. The catalyst system is obtained by combining: (a) metal of Group VIII or a compound thereof: and (b) a bidentate phosphine of general formula (I) The carbonylation reaction is carried out at a temperature of between -30°C to 49°C and under a CO partial pressure of less than 30 x105 N.m-2.

A catalyst system

The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: a) a metal of Group VIB or Group VIIIB or a compound thereof, b) a bidentate phosphine, arsine or stibine ligand, and c) an acid, wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and that said acid is present in at least a 2:1 molar excess compared to said ligand, a process for the carbonylation of an ethylenically unsaturated compound, a reaction medium, and use of the system.

Phosphacycle-containing ligand for chromium complex and olefin oligomerisation catalyst therefrom

The present invention relates to a composition comprising a phosphacycle-containing ligating compound represented as: wherein: P is phosphorus; X 1 is phosphorus; each of R 1 and R 2 is independently a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; m is 1; R 1 and R 2 are linked together to form a divalent moiety represented as which together with P forms a cyclic structure (phosphacycle) containing from 3 to 10 ring atoms; each of R 3 and R 4 is independently hydrogen, halogen, a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; R 3 and R 4 are optionally linked together to form a divalent moiety represented as wherein the optional character of the linkage is depicted by a dashed connection, which together with X 1 forms a cyclic structure containing from 3 to 10 ring atoms; Y is a divalent linking group [L(R 5 ) q ] p between P and X 1 containing from one to 50 non-hydrogen atoms; [L(R 5 ) q ] p is represented by: wherein each L is independently selected from the group consisting of nitrogen; p is an integer number from 1 to 6; R 5 is independently hydrogen, halogen, substituted or unsubstituted hydrocarbon derivative, substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group; q is 0, 1, or 2; provided that the [L] p subunit of the divalent linking group [L(R 5 ) q ] p does not comprise an amidine (N-C=N) group; further provided that in at least one phosphacycle of the phosphacycle-containing ligating compound, both atoms directly bonded to P or X 1 are sp 3 hybridized; still further provided that one or two phosphacycles comprising P, R 1 , and R 2 , or comprising X 1 , R 3 , and R 4 , contain no P-N, ...

Chromium complex with a phosphacycle-containing ligand and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound.

Catalyst, hydrogenation of hydrogen carbonate, hydrogen storage system

The invention relates to a catalyst according to the formula lrCI(cod)(NHC)] + nP (n = 2, 3 or 4), or [lr(cod)(NHC)(P)] + nP (n = 1, 2 or 3), which is suitable to decompose formates in an aqueous reaction system, and for the production of hydrogen gas or hydrogenation of carbonates, wherein Ir means irydium; CI means chlorine; cod means 1,5-cyclooctadiene; NHC means N-heterocyclic carbene, preferably 1-R-3-methylimidasolium chloride, wherein R means C 1-5 alkyl es P means 1,3,5-triaza-7-phosphaadamantane (pta), monosulphonated triphenilphosphine ( m tppms), trisulphonated triphenylphosphine ( m tppts), or four times sulphonated diphenylphosphynopropane (dpppts). Furthermore, the invention relates to a process for the preparation of the catalyst accoring to the invention. Further, the invention relates to a process for the decomposition of formate in aqueous reaction system, and for the production of hydrogen gas free of CO x , still further, a process for the hydrogenation of hydrogen carbonate in an aqueous reaction system, as well as the production of the respective formate. Further, the invention relates to a process for the decomposition of formate accoring to the invention, and the hydrogenation of the carbonate generated in the same reaction system. The invention relates to a hydrogen storage system based on the process according to the invention, preferably battery or fuel cell, and the use thereof.

二膦的制备方法

一种制备通式为(R 3 -C) 2 P-L 1 -X-L 2 -P-(C-R 3 ) 2 的化合物的方法，其中每个R独立地为任选取代的侧有机基团，通过它该基团与叔碳原子C连接；L 1 、L 2 独立地为连接基团，选自将各自的磷原子与基团X连接的任选取代的低级亚烷基链，X为包括任选取代的芳基部分的桥连基，该芳基部分通过可得到的相邻碳原子与磷原子连接，该方法包括：i)将式H-L 1 -X-L 2 -H所示的化合物与有机金属化合物一起反应，生成式M-L 1 -X-L 2 -M所示的中间体化合物，其中M为碱金属原子，ii)将所述中间体化合物与式(R 3 -C) 2 P-A所示的化合物反应，其中A为卤原子，形成所述通式为(R 3 -C) 2 P-L 1 -X-L 2 -P-(C-R 3 ) 2 的化合物。M优选为锂、钾或钠，中间体化合物可以分离或不分离。反应(i)可在诸如四甲基乙二胺的络合剂存在下有利地进行。

Diphosphine ligand and transition metal complex using the same

신규 리간드를 개시한다. 또한 다양한 비대칭 합성 반응에서 우수한 거울상체선택성 및 촉매 효율을 지니는, 특히 높은 촉매 활성을 보이는, 리간드를 이용하여 제조되는 신규 전이 금속 착물을 개시한다. 전이 금속 착물은 리간드로서 하기 화학식으로 표시되는 화합물을 가진다: New ligands are disclosed. Also disclosed are novel transition metal complexes prepared using ligands which exhibit particularly high catalytic activity, with excellent enantioselectivity and catalytic efficiency in various asymmetric synthesis reactions. The transition metal complex has a compound represented by the following formula as ligand: [식 중, R 4 는 수소 원자 또는 치환체를 가질 수 있는 C 1 -6 알킬기이고; R 5 및 R 6 는 독립적으로 치환체를 가질 수 있는 C 1 -6 알킬기이고, 또는 화학식 에서 R 5 및 R 6 는 함께 화학식 로 표시되는 화학식을 형성할 수 있음 [Wherein, R 4 is C 1 -6 alkyl group which may have a hydrogen atom or a substituent; R 5 And R 6 is a C 1 -6 alkyl group which may have a substituent, each independently, or formula R 5 And R 6 together with the formula May form a chemical formula represented by (식 중, 고리 B 는 치환체를 가질 수 있는 3- 내지 8-원 고리임)]. Wherein ring B is a 3- to 8-membered ring which may have substituents.

Catalyst

CATALYSTS FOR THE CONDUCT OF CROSSED COUPLING REACTIONS.

SE PROPONE UN SISTEMA DE CATALIZADOR, EN ESPECIAL PARA LAS REACCIONES DE ACOPLAMIENTO CRUZADAS, QUE SE PUEDE OBTENER MEDIANTE REACCION A) DE UNA COMPOSICION DE PALADIO (II) CON B) UN LIGANDO DE FOSFANO SOLUBLE EN AGUA Y C) UN SULFOXIDO O UN ALCOHOL POLIVALENTE. A CATALYSTING SYSTEM IS PROPOSED, ESPECIALLY FOR CROSSED COUPLING REACTIONS, WHICH CAN BE OBTAINED BY REACTION A) OF A PALADIO COMPOSITION (II) WITH B) A WATER SOLUBLE PHOSPHANE BINDING AND C) A SULFOXIDE OR A POLYAL ALCOHOL .

Phosphorus substituted metallocene compounds for olefin polymerization

This invention relates to a metallocene compounds represented by formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is an indenyl ligand that is substituted with a PR 2 group in the two position of the indenyl ligand, where each R is, independently a hydrocarbyl, substituted hydrocarbyl, halocarbyl, or substituted halocarbyl substituent, and additionally, E may be substituted with 0, 1, 2, 3, 4, 5 or 6 R n where each R n is, independently, a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent, and optionally, two or more adjacent R n substituents may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand, or A may, independently, be defined as E or as X; each X is, independently, an univalent anionic ligand, or both X are joined and bound to the metal atom to form a metallocycle ring, or both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand.

A catalyst system

A CATALYST SUITABLE FOR CARBONYLATING ETHYLENICALLY UNSATURATED COMPOUNDS COMPRISING A GROUP VIIIB METAL OR COMPOUND THEREOF AND A METALLOCENE.

New optically active organo phosphorus compound useful to prepare phosphine-metal catalysts useful to carry out asymmetrical syntheses in organic chemistry

Optically active organo phosphorus compound (I) in which the phosphorus atom carries chirality and a (hetero)aryl group functionalized in position ortho or 2, is new. Optically active organo phosphorus compound of formula (I) in which the phosphorus atom carries chirality and a (hetero)aryl group functionalized in position ortho or 2, is new. P 1>asymmetric P; m : >=1; n : 0-1; E : 2 electrons, BH 3, HBF 4, TfDH, HClO 4, HPF 6, HBr, HI, HCl, HF, CH 3COOH, CH 3COOH or MsOH; R 3>, R 4>H, 1-4C alkyl or 1-4C alkoxy (optionally substituted by F and/or 1-4C alkyl or 1-4C alkoxy (optionally substituted)); R 3>R 4>5-6C cycloalkane, dioxolane, dioxane or Ar e.g. naphth-1,8-diyl (optionally substituted); z : bond between (CR 3>R 4>) nand Z; Ar 1>4-14C (poly)aromatic ring (bonded to P 1>by a bond (x) and bonded to a group Z(CR 3>R 4>) nby a bond (y), where Z(CR 3>R 4>) nis in ortho or 2 position to P 1>) (optionally includes N, O, S or optionally carry N, O, Si, halo and/or optionally substituted 1-10C alkyl and/or alkoxy or form a cyclic ring of Ar and P as phosphino-Ar e.g. phosphinobenzene, 1-phosphinonaphtalene, 2-phosphinonaphtalene, N(R 5>)-2-methyl-7-phosphinoindole or N-(R 5>)-7-phosphinoindoline and Z(CR 3>R 4>) n-Ar-phosphino is N-(R 5>)-2-phosphinopyrrole or N(R 5>)-2-phosphmoindole); R 5>e.g. a carbon skeleton of formula (II); OR 5>(when m is 1) : e.g. 2,3- dihydro-2,2-dimethyl-7-benzofuranyl ring of formula (III); Z : OR 5>, SR 5>, SO 2R 5>, N(R 6>R 7>), C(O)N(R 6>R 7>), N(R 5>), 1-10C trialkylsilyl, triphenylsilyl, 5-14C (hetero)aryl (optionally substituted by F or 1-10C alkyl); A : C, O, S or TsN, CH, CH 2, Si(R 51>) 2-O-Si(R 51>) m1, benzene or pyridine; R 51>1-10C alkyl; m1 : >=1; A 1>-A 4>CH 2or (R 51>)CH; B 1>-B 4>CH 2, C(O), SO 2, (R 8>R 9>)Si, C(O)N or C(O)O; R 8>, R 9>1-18C alkyl, 5-8C cycloalkyl or 6-10C aryl (all ...

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle compounds and process for preparation thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Olefin oligomerisation process with a catalyst comprising a chromium complex with a phosphacycle-containing ligand

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

催化剂体系

一种适用于羰基化烯属不饱和化合物的催化剂，该催化剂含有第VIIIB族金属或其化合物以及金属茂。

Katalizátor és eljárás hidrogéngáznak formiátból történõ elõállítására és hidrogénkarbonát hidrogénezésére, és az ezeket alkalmazó hidrogéntároló rendszer

New diphosphine compound, intermediates for their preparation, transition metal complex containing the compound as ligand and catalyst for asymmetric hydrogenations containing the complex

HYDRATION CATALYST, METHOD FOR THE PRODUCTION THEREOF AND HYDRATION METHOD

Catalyst system

FIELD: chemistry. SUBSTANCE: present invention relates to a new catalyst system, a new carbonylation reaction medium and to a method of carbonylation of ethylene-unsaturated compounds using the new catalyst system. The catalyst system, which is capable of catalysing carbonylation of an ethylene-unsaturated compound, can be obtained by combining: a) group VIIIB metal, or its compound, b) bidentate phosphinic or arsinic ligand and c) acid, where the said ligand is present in molar excess of at least 2:1, compared to the said metal or said metal in its compound, and the said acid is present in molar excess ranging from 5:1 to 95:1, compared to the said ligand. In another version the catalyst system, which is capable of catalysing carbonylation of an ethylene-unsaturated compound, can be obtained by combining: a) group VIIIB metal, or its compound, b) bidentate phosphic or arsinic ligand and c) acid, where molar ratio of the said ligand to the said metal or said metal in its compound lies in the range greater than 5:1 to 750:1, and the said acid is present in molar excess of at least 2:1, compared to the said ligand. EFFECT: invention also relates to a method of carbonylation of an ethylene-unsaturated compound, a reaction medium, use of catalyst a system and a complex, which is capable of catalysing carbonylation of an ethylene-unsaturated compound. 39 cl, 35 ex, 9 tbl, 3 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 372 989 (13) C2 (51) МПК B01J B01J B01J C07C 31/24 (2006.01) 23/44 (2006.01) 23/74 (2006.01) 51/14 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2006133287/04, 17.02.2005 (24) Дата начала отсчета срока действия патента: 17.02.2005 (72) Автор(ы): ИСТХЭМ Грэхам (GB), ТИНДЭЙЛ Нил (GB) (43) Дата публикации заявки: 27.03.2008 2 3 7 2 9 8 9 (45) Опубликовано: 20.11.2009 Бюл. № 32 (56) Список документов, цитированных в отчете о поиске: US 2002/045748 A1, 18.04.2002. WO ...

烯烃氢甲酰化反应的Co基多相催化剂及制备和应用

本发明涉及一种Co基多相催化剂制备方法及其应用，更具体地，涉及一种应用于高碳烯烃氢甲酰化反应的Co基多相催化剂，其由金属组分和有机膦配体聚合物组成，所述金属组分是金属Co，所述有机膦配体聚合物是含有乙烯基的有机膦配体经溶剂热聚合生成具有大比表面积和多级孔道结构的聚合物。本发明催化剂在高碳烯烃氢甲酰化反应中，反应活性和产物醛选择性优异，反应稳定性良好。采用新型Co基多相催化剂，降低了催化剂同反应物和产物的分离成本，适应于大规模工业化生产；同时选用非贵金属Co作为催化剂金属活性组分，有效提高了氢甲酰化反应过程的经济性。

Phosphor, Arsenic And Antimony Compounds Based Upon Diaryl-anellated Bicyclo[2.2.n] Parent Substances And Catalysts Containing Same

인, 비소 및 안티몬의 신규 화합물들을 리간드로 사용하여 8 족의 전이 금속 착물을 형성할 수 있으며, 이들은 히드로포르밀화 반응, 히드로시안화 반응, 카르보닐화 반응, 수소화 반응, 올레핀 올리고머화 반응 및 올레핀 중합 반응, 그리고 복분해 반응(metathesis)을 위한 촉매로서 사용될 수 있다. New compounds of phosphorus, arsenic and antimony can be used as ligands to form Group 8 transition metal complexes, which are hydroformylation, hydrocyanation, carbonylation, hydrogenation, olefin oligomerization and olefin polymerization Reactions, and can be used as catalysts for metathesis. 인, 비소 및 안티몬 화합물, 리간드, 8 족의 전이 금속 착물, 히드로포르밀화 반응, 히드로시안화 반응, 카르보닐화 반응. Phosphorus, arsenic and antimony compounds, ligands, transition metal complexes of Group 8, hydroformylation reactions, hydrocyanation reactions, carbonylation reactions.

Olefin oligomerisation process with a catalyst comprising a chromium complex with a phosphacycle-containing ligand

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Chromium complex with a phosphacycle-containing ligand and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle-containing ligand for chromium complex and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle-containing ligand for chromium complex and olefin oligomerisation catalyst therefrom

The present invention relates to a composition comprising a phosphacycle-containing ligating compound represented as: wherein: P is phosphorus; X 1 is phosphorus; each of R 1 and R 2 is independently a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; m is 1; R 1 and R 2 are linked together to form a divalent moiety represented as which together with P forms a cyclic structure (phosphacycle) containing from 3 to 10 ring atoms; each of R 3 and R 4 is independently hydrogen, halogen, a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; R 3 and R 4 are optionally linked together to form a divalent moiety represented as wherein the optional character of the linkage is depicted by a dashed connection, which together with X 1 forms a cyclic structure containing from 3 to 10 ring atoms; Y is a divalent linking group [L(R 5 ) q ] p between P and X 1 containing from one to 50 non-hydrogen atoms; [L(R 5 ) q ] p is represented by: wherein each L is independently selected from the group consisting of nitrogen; p is an integer number from 1 to 6; R 5 is independently hydrogen, halogen, substituted or unsubstituted hydrocarbon derivative, substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group; q is 0, 1, or 2; provided that the [L] p subunit of the divalent linking group [L(R 5 ) q ] p does not comprise an amidine (N-C=N) group; further provided that in at least one phosphacycle of the phosphacycle-containing ligating compound, both atoms directly bonded to P or X 1 are sp 3 hybridized; still further provided that one or two phosphacycles comprising P, R 1 , and R 2 , or comprising X 1 , R 3 , and R 4 , contain no P-N, ...

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

用于铬络合物的含有磷环的配体和由其得到的烯烃低聚催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

chromium complex with a phosphacyl-containing binder and olefin oligomerization catalyst thereof

a invenção se refere à oligomerização de olefinas, tais como etileno, para olefinas superiores, tais como uma mistura de 1-hexeno e 1-octeno, utilizando um sistema de catalisador que compreende a) uma fonte de cromo b) um ou mais ativadores e c) um composto de ligação contendo fosfaciclo. adicionalmente, a invenção se refere a um composto de ligação contendo fosfaciclo e a um processo para a preparação do referido composto. The invention relates to oligomerization of olefins such as ethylene to higher olefins such as a mixture of 1-hexene and 1-octene using a catalyst system comprising a) a source of chromium b) one or more activators and ) a phosphate cyclic binding compound. In addition, the invention relates to a phosphatocycle-containing binding compound and to a process for preparing said compound.

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

phosphaclic-containing binder for chromium complex and olefin oligomerization catalyst thereof

a invenção se refere a oligomerização de olefinas, tais como etileno, até olefinas superiores, tal como uma mistura de 1-hexeno e 1-octeno, utilizando um sistema de catalisador que compreende a) uma fonte de cromo b) um ou mais ativadores e c) um composto de ligação contendo fosfaciclo. adicionalmente, a invenção se refere a um composto de ligação contendo fosfaciclo e a um processo para a preparação do referido composto. The invention relates to oligomerization of olefins such as ethylene to higher olefins such as a mixture of 1-hexene and 1-octene using a catalyst system comprising a) a source of chromium b) one or more activators and ) a phosphate cyclic binding compound. In addition, the invention relates to a phosphatocycle-containing binding compound and to a process for preparing said compound.

olefin oligomerization process with a catalyst comprising a chromium complex with a phosphate-containing binder

a invenção se refere à oligomerização de olefinas, tais como etileno, até olefinas superiores, tal como uma mistura de 1-hexeno e 1-octeno, utilizando um sistema de catalisador que compreende a) uma fonte de cromo b) um ou mais ativadores e c) um composto de ligação contendo fosfaciclo. adicionalmente, a invenção se refere a um composto de ligação contendo fosfaciclo e a um processo para a preparação do referido composto. The invention relates to oligomerization of olefins such as ethylene to higher olefins such as a mixture of 1-hexene and 1-octene using a catalyst system comprising a) a source of chromium b) one or more activators and ) a phosphate cyclic binding compound. In addition, the invention relates to a phosphatocycle-containing binding compound and to a process for preparing said compound.

Phosphacycle compound and process for production thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle compounds and process for preparation thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

具有含有磷环的配体的铬络合物和由其得到的烯烃低聚反应催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle-containing ligand for chromium complex and olefin oligomerization catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

用于铬络合物的含有磷环的配体和由其得到的烯烃低聚催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Chromium complex with a phosphacycle-containing ligand and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

具有含有磷环的配体的铬络合物和由其得到的烯烃低聚反应催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

A catalyst system

A catalyst system

双配位膦配体

本发明涉及一种双配位膦配体，膦的磷原子由桥基连接，双配位膦配体的桥基由含两个芳基的一种邻位稠化的环状体系所组成，其芳基由两个桥相连接，第一个桥用一个-O-或一个-S-原子所组成，第二个桥是含一个氧、硫、氮、硅或碳原子或这些原子的组合的一个基团，两个磷原子在第一个桥的-O-或-S-原子的邻位与两个芳基相连。本发明还涉及将该双配位膦配体用于一种还含一种过渡金属化合物的催化体系，该体系可用于以下类型的反应：氢甲酰化、氢化、氢氰化、聚合、异构化、羰基化、交联和复分解。

STABLE C - (sup3) - CYCLOMETALATED PINCER COMPLEXES, THEIR PREPARATION AND USE AS CATALYSTS

The invention relates to a novel class of stable pincer complexes comprising a pinσer ligand linked to the metal via a Calfa cyclometalated carbon and via two donor atoms W1 and W2, wherein said Calfa carbon has a sp3 hybridization; said Calfa carbon is bonded to three Cbeta carbons; each of said Cbeta carbons is linked to the non-hydrogen atoms,- and W1 and W2 are independently selected from P, As, N or O. Said complexes are used as catalyst in transfer hydrogenation reactions such as reduction of ketones, reductions of imines and reductions of olefines.

A catalyst system comprising a 1,2-bis-(phosphinoalkyl) ferrocene ligand

A catalyst suitable for carbonylating ethylenically unsaturated compounds comprising a Group VIIIB metal or compound thereof and a metallocene.