КАТАЛИТИЧЕСКАЯ СИСТЕМА

... 1. Каталитическая система, способная катализировать карбонилирование этилен-ненасыщенного соединения, эта система может быть получена посредством объединенияa) металла группы VIB или группы VIIIB, или его соединения,b) бидентатного фосфинового, арсинового или стибинового лиганда иc) кислоты,где указанный лиганд присутствует в молярном избытке, по меньшей мере, 2:1, по сравнению с указанным металлом или указанным металлом в соединении указанного металла, и указанная кислота присутствует в молярном избытке, по меньшей мере, 2:1, по сравнению с указанным лигандом.2. Каталитическая система по п.1, в которой соотношение указанного лиганда к указанному металлу находится в пределах 5:1-750:1.3. Каталитическая система по п.1, в которой соотношение указанного лиганда к указанному металлу находится в пределах 10:1-500:1.4. Каталитическая система по п.1, в которой соотношение указанного лиганда к указанному металлу находится в пределах 20:1-40:1,5. Каталитическая система по п.1, в которой соотношение ...

VERFAHREN ZUR HERSTELLUNG VON N-OCTADIENOL

Neue Diphosphinverbindung, Zwischenprodukte für deren Herstellung, Übergangsmetallkomplex enthaltend die Verbindung als Ligand und Katalysator für asymmetrische Hydrierungen, welcher den Komplex enthält

Verwendung von molekulargewichtsvergrößerten Katalysatoren in einem Verfahren zur asymmetrischen kontinuierlichen Hydrierung, neue molekulargewichtsvergrößerte Liganden und Katalysatoren

Die vorliegende Erfindung richtet sich auf eine Verwendung von molekulargewichtsvergrößerter homogen löslicher Katalysatoren Verfahren zur asymmetrischen kontinuierlichen Hydrierung von C=C-, C=N- oder C=O-Doppelbindungen mittels molekulargewichtsvergrößerter homogen löslicher Katalysatoren in einem Membranreaktor. DOLLAR A Bisherige im Stand der Technik vorgeschlagene Hydrierverfahren liefen diskontinuierlich ab. Die kontinuierliche Fahrweise hilft dagegen Prozeßkosten zu sparen. DOLLAR A Angegeben werden auch neue molekulargewichtsvergrößerte Liganden und Katalysatoren.

Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator

Novel metallocene-based phosphorus chiral phosphines

VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEN ALFA-N-ACYLAMINO-PROPIONSAUREN

PROCEDURE FOR THE PRODUCTION OF OPTICALLY ACTIVE ONE ALFA N ACYLAMINO PROPIONSAUREN

PROCEDURE FOR THE PRODUCTION OF OPTICALLY ACTIVE ONE ALFA N ACYLAMINO PROPIONSAUREN

PROCEDURE FOR THE PRODUCTION OF NEW DIPHOSPHINEN

ASSEMBLY-METRIC LIGANDS FOR USE IN TRANSITION METAL-CATALYZED SYNTHESES AND EQUIVALENT EPOXY REACTIONS

BY TRANSITION METAL COMPLEXES WITH CYCLIC CHIRALEN ASYMMETRICAL SYNTHESIS CATALYZED LIGANDS

Chiral phosphorated ligands useful in catalysts

PROCESS FOR THE PRODUCTION OF ASYMMETRIC TRANSFORMATION CATALYSTS

The present invention relates to process for the production of chiral ligands comprising providing a starting material of Formula (A): wherein X* is a chiral or achiral directing group; and (i) is an optionally substituted mono- or polycyclic aryl or cycloalkyl group; ortholithiating the substrate; converting the ortho-lithiated substrate to a phosphine group having the formula -PR1 R1", R1 being selected from substituted and unsubstituted, branched- and straight-chain alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted carbocyclic aryl, and substituted and unsubstituted heteroaryl wherein the or each heteroatom is independently selected from sulphur, nitrogen, and oxygen, R1" being different from R1 and being selected from substituted and unsubstituted, branched- and straight- chain alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted carbocyclic aryl, and substituted and unsubstituted heteroaryl wherein the or each heteroatom is independently ...

PROCESS FOR PREPARING OPTICALLY ACTIVE CITRONELLAL

Le citronellal optiquement actif est préparé par hydrogenation du néral ou du géranial en présence d'un catalyseur constitué par un complexe soluble dans le milieu réactionnel, formé à partir d'un dérivé du rhodium et d'une phosphine chirale. Le procédé de l'invention permet d'accéder au d-citronnellal intermédiaire de la synthèse du (-) (IS) menthol.

AN ADAMANTYL CATALYST SYSTEM

... ²²²A catalyst system capable of catalysing the carbonylation of an olefinally ²unsaturated compound is described. The 5 catalyst system is obtainable by ²combining: (a) a metal of Group VIB or Group VIII B or a compound thereof; and ²(b) a bidentate phosphine of general formula (I) Ad) s (CR4R5R6) T Q2-A- (K, ²D) Ar (E, Z) -B-Q1 (Ad) u (CR1R2R3) v. Ad represents an optionally substituted ²adamantyl radical bonded to the phosphorous atom via any one of its tertiary ²carbon atoms. A method of production of the catalyst is also illustrated.² ...

METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE

The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

PHOSPHORUS SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION

This invention relates to a metallocene compounds represented by formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is an indenyl ligand that is substituted with a PR2 group in the two position of the indenyl ligand, where each R is, independently a hydrocarbyl, substituted hydrocarbyl, halocarbyl, or substituted halocarbyl substituent, and additionally, E may be substituted with 0, 1, 2, 3, 4, 5 or 6 R° where each R' is, independently, a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent, and optionally, two or more adjacent R° substituents may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand, or A may, independently, be defined as E or as X; each X is, independently, an univalent anionic ligand, cz both X are joined and bound to the metal atom to, form a metallocycle ring, or, both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand.

Bicyclooctyl phosphines and catalysts thereof

Bicyclooctyl phosphines are disclosed having the formula: см. иллюстрацию в PDF-документе where R is C1 to C6 linear or branched alkyl, phenyl, substituted phenyl, halo, or C1 or C6 alkoxy; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; and x is 0 or 1. These phosphines are treated with ruthenium compounds to form a complex of the formula Rux Hy Clz (anthraphos-m)2 (S)p, where S is a tertiary amine; and when y is 0, then x is 2, z is 4 and p is 1; and when y is 1, then x is 1, z is 1 and p is 0; where anthraphos-m is: см. иллюстрацию в PDF-документе where R is C1 to C6 linear or branched alkyl, phenyl, substituted phenyl, C1 to C6 linear or branched alkoxy or halo; Ar is phenyl or substituted phenyl or naphthyl or substituted naphthyl; and m is 0 or 1. The complex is useful in a process for the asymmetric reduction of olefinic carboxylic acids of the formula: см. иллюстрацию в PDF-документе where R1 and R2 are the same or different and are hydrogen, alkyl, cycloalkyl ...

Diphosphines, their complexes with transisition metals and their use in asymmetric synthesis

The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I):in which:R1 and R2 are a (C5-C7)cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; andA is (CH2-CH2) or CF2.The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).

Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

Non-C₂-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C₂-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

Homogeneous Asymmetric Hydrogenation Process

Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

Ruthenium-iodo-optically active phosphine complex

PROCESS FOR PREPARING OPTICALLY ACTIVE CITRONELLAL

SUBSTITUTED ACRYLIC ACID AND ASYMMETRIC HYDROGENATION OF SAME ESTER

RUTHENIUM-PHOGPHINE COMPLEX AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To obtain a ruthenium-phosphine complex which is stable and has high catalytic activity. SOLUTION: This complex shown by the formula {[RuX(L)]2(μ-X)3}-[R22 NH2]+ {R2 is H, a 1-5C alkyl, a cycloalkyl, or the like; L is a diphosphine ligand shown by the formula [R1 is a (substituted) phenyl, naphthyl, or the like; X is a halogenl (e.g. {[RuCl((S)-SEGPHOS)]2(μ-Cl)3}-[Et2NH2]4) is obtained by reacting a ruthenium complex shown by the formula [RuX(arene)(L)]X [X is a halogen; arene is a (substituted) phenyl; L is a tertiary diphosphine ligand shown by the formula] with an ammonium salt of the formula R22NHHN. The ruthenium complex shown by the formula [RuX(arene)(L)]X is obtained by reacting [RuCl2(arene)]2 with a tertiary duphosphine L in a solvent such as methanol at 20-50°C for 1-3 h when X is chlorine. COPYRIGHT: (C)1999,JPO ...

Способ получения оптически активных аминокислот

CHIRALE PHOSPHORIERTE LIGANDE BRAUCHBAR IN KATALYSATOREN

YMMETRISCHE UMWANDLUNGEN

Process for the carbonylation of ethylenically unsaturated compounds

VERFAHREN ZUR HERSTELLUNG VON NEUEN DIPHOSPHINEN

PROCEDURE FOR THE PRODUCTION OF CATALYSTS FOR ASYMMETRICAL TRANSFORMATIONS

OPTICALLY ACTIVE ONES DIPHOSPHINVERBINDUNG, INTERMEDIATE PRODUCTS FOR ITS PRODUCTION, TRANSITION METAL COMPLEX CONTAINING THE CONNECTION AS LIGAND AND CATALYST FOR ASYMMETRICAL HYDROGENATIONS, OF WHICH CONTAINS THE COMPLEX

CHIRALE PHOSPHORIERTE LIGANDE USEFUL IN CATALYSTS

A PHOSPHA-ADAMANTANE (S) CATALYTIC SYSTEM

LIGANDS

A substituted paracyclophane is described of formula (I) wherein Xl and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl , aryl or heteroaryl, Z1, Z2 and Z3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or l and a + b + c + d + e + f = 1 to 6. PreferablyX1 and X2 are -(C2H4)- and a + b + c + d + e + f = 1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions.

USE OF MOLECULAR WEIGHT-ENLARGED CATALYSTS IN A PROCESS FOR ASYMMETRIC, CONTINUOUS HYDROGENATION, NOVEL MOLECULAR WEIGHT-ENLARGED LIGANDS AND CATALYSTS

The present invention relates to a use of molecular weight- enlarged, homogeneously soluble catalysts in a process for the asymmetric, continuous hydrogenation of C=C, C=N or C=O double bonds by means of molecular weight-enlarged, homogeneously soluble catalysts in a membrane reactor. Hydrogenation processes hitherto proposed in the prior art operate discontinuously. Continuous operation, in contrast, helps to save on process costs. Novel molecular weight-enlarged ligands and catalysts are also stated.

A CATALYST SYSTEM

... ²²²The present invention provides a catalyst system capable of catalysing the ²carbonylation of an ethylenically unsaturated compound, which system is ²obtainable by combining: a) a metal of Group VIB or Group VIIIB or a compound ²thereof, b) a bidentate phosphine, arsine or stibine ligand, and c) an acid, ²wherein said ligand is present in at least a 2:1 molar excess compared to said ²metal or said metal in said metal compound, and that said acid is present in ²at least a 2:1 molar excess compared to said ligand, a process for the ²carbonylation of an ethylenically unsaturated compound, a reaction medium, and ²use of the system.² ...

SYNTHESIS OF NON-C2-SYMMETRIC BISPHOSPHINE LIGANDS AS CATALYSTS FOR ASYMMETRIC HYDROGENATION

Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

CALIXARENE-BOUND IRIDIUM-CONTAINING METAL COLLOIDS

The invention provides complexes in which a calixarene-related compound is coordinated to an iridium-containing metal colloid. The complexes can be immobilized on a substrate. The complexes of the invention are useful as tunable and highly robust isolated metal colloids that find use in binding of molecules and catalysis of chemical reactions.

A catalyst system

METHOD OF PREPARATION OF N-OCTADIENOL

METHOD OF PREPARATION OF N-OCTADIENOL

L'INVENTION PROPOSE UN PROCEDE DE PREPARATION DE N-OCTADIENOL. CONFORMEMENT A L'INVENTION: I)ON FAIT REAGIR DU BUTADIENE ET DE L'EAU DANS UNE SOLUTION AQUEUSE DE SULFOLANE PRESENTANT UN RAPPORT PONDERAL EAUSULFOLANE D'UNE VALEUR DE 2080 A 7030 ET CONTENANT DES IONS CARBONATE ETOU BICARBONATE EN PRESENCE DE A DU PALLADIUM OU UN COMPOSE DE PALLADIUM, B UNE PHOSPHINE MONODENTEE DE FORMULE: (CF DESSIN DANS BOPI) DANS UNE QUANTITE AU MOINS EGALE A 6MOLES PAR ATOME-GRAMME DE PALLADIUM ET C UNE AMINE TERTIAIRE MONODENTEE AYANT UNE CONSTANTE DE BASICITE PKA DE 7 OU DAVANTAGE DANS UNE QUANTITE DE 1 A 50 EN VOLUME, BASEE SUR LE SULFOLANE, AFIN DE FORMER DU N-OCTADIENOL; II)ON SOUMET AU MOINS UNE PARTIE DU MELANGE REACTIONNEL OBTENU DANS L'ETAPE I) A UNE EXTRACTION AVEC UN HYDROCARBURE ALIPHATIQUE SATURE, UN HYDROCARBURE MONO-OLEFINIQUE OU UN HYDROCARBURE ALICYCLIQUE; ET III)ON RECYCLE AU MOINS EN PARTIE LE RESIDU D'EXTRACTION OBTENU AU COURS DE L'ETAPE II) ET QUI CONTIENT LES CONSTITUANTS CATALYSEURS VERS L'ETAPE I). PAR CE PROCEDE, LE N-OCTADIENOL EST PRODUIT AVEC UNE VITESSE ET UNE SELECTIVITE ELEVEES. THE INVENTION PROVIDES A PROCESS FOR PREPARING N-OCTADIENOL. IN ACCORDANCE WITH THE INVENTION: I) BUTADIENE AND WATER ARE REACTED IN AN AQUEOUS SOLUTION OF SULFOLANE WITH A WEIGHT EAUSULFOLANE RATIO OF A VALUE OF 2080 TO 7030 AND CONTAINING CARBONATE AND BICARBONATE IONS IN THE PRESENCE OF A PALLADIUM OR A COMPOUND OF PALLADIUM, B A MONODENTAL PHOSPHINE OF FORMULA: (CF DRAWING IN BOPI) IN AN AMOUNT AT LEAST EQUAL TO 6 MOLES PER ATOM-GRAM OF PALLADIUM AND C A MONODENTAL TERTIARY AMINE HAVING A CONSTANT OF PKA BASICITY OF 7 OR MORE IN A QUANTITY OF 1 TO 50 BY VOLUME, BASED ON SULFOLANE, TO FORM N-OCTADIENOL; II) AT LEAST PART OF THE REACTIONAL MIXTURE OBTAINED IN STEP I) IS SUBJECTED TO EXTRACTION WITH A SATURATED ALIPHATIC HYDROCARBON, A MONO-OLEFINIC HYDROCARBON OR AN ALICYCLIC HYDROCARBIDE; AND III) AT LEAST PART OF THE EXTRACTION RESIDUE ...

NEW DIPHOSPHINES, THEIR COMPLEXES WITH METALS OF TRANSITION AND LEURUTILISATION IN ASYMMETRICAL SYNTHESIS

IMPROVED SEPARATION PROCESSES

This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal- organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a polar solvent and said one or more products, wherein said process comprises (1) mixing said reaction product fluid with a nonpolar solvent to obtain by phase separation a polar phase comprising said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and said polar solvent and nonpolar phase comprising said one or more products and nonpolar solvent, and (2) recovering said nonpolar phase from said polar phase; wherein said organophosphorus ligand has a partition coefficient between the polar solvent and the nonpolar solvent of greater than about 10, and said one or more products have a partition coefficient between the nonpolar solvent and the polar solvent of greater than about 0.5. © KIPO & WIPO 2007 ...

Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

WATER-INSOLUBLE RUTHENIUM CATALYST COMPOSITION FOR USE IN AQUEOUS HYDROGENATION REACTIONS

The invention relates to a method for converting a precatalyst complex to an active catalyst complex, wherein the precatalyst complex and the active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, and the active catalyst complex furthermore comprises a monohydride and a water molecule. The method comprises the steps of providing water as an activation solvent system with a pH value equal or below 2, and solving said precatalyst complex, an acid, and hydrogen therein. The invention further relates to a method for manufacturing a catalyst composition, a method for hydrogenating a substrate molecule and a reaction mixture. 1. A method for converting a precatalyst complex to an active catalyst complex ,wherein said precatalyst complex and said active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, andwherein said active catalyst complex comprises a monohydride and a water molecule,said method comprising the steps of:a) providing an activation solvent system comprising water, said precatalyst complex,', 'a solubilizer,', 'an acid, and', 'hydrogen,, 'b) adding to, particularly solving in, said activation solvent system'}characterized in thatthe pH value of said activation solvent system is equal or below 2 after addition of said acid.2. The method according to claim 1 , wherein said activation solvent system comprises ≧50% (v/v) claim 1 , ≧75% (v/v) claim 1 , ≧80% (v/v) claim 1 , ≧90% (v/v) claim 1 , ≧99% (v/v) or 100% water.3. The method according to claim 1 , wherein said solubilizer is a surfactant that is capable of forming micelles in water and that is resistant to hydrolysis at pH≦2.4. A method for obtaining a catalyst composition claim 1 , comprising the steps ofa) providing water as a preparation solvent system, andb) adding to, particularly solving in, said preparation solvent system an optically active ligand, wherein said optically active ligand is ...

Novel diphosphine compound, production intermediate thereof, transition metal complex containing the compound as ligand and asymmetric hydrogenation catalyst containing the complex

The present invention provides a novel phosphine compound, specifically to provide a novel phosphine compound useful as a ligand for the above catalysts, in particular, a novel catalyst having an excellent performance (chemical selectivity, enantio-selectivity, catalytic activity) as a catalyst for asymmetric syntheti reactions, particularly asymmetric hydrogenation. A diphosphine compound represented by the general formula (1) : wherein R1 and R2 each independently represents a lower alkyl group, a cycloalkyl group, an unsubstituted or substituted phenyl group, or a five-membered heteroaromatic ring residue.

METAL-CATALYZED ALKOXYCARBONYLATION OF A LACTONE

NOVEL STEROIDIC CHRAL PHOSPHINES, MANUFACTURE, CATALYST CONTAINING THEM AND CATALYTIC METHOD THEREBY

КАТАЛИЗИРУЕМОЕ МЕТАЛЛОМ АЛКОКСИКАРБОНИЛИРОВАНИЕ ЛАКТОНА

Катализируемое металлом алкоксикарбонилирование лактона представляет собой способ алкоксикарбонилирования δ-лактона, в частности 3-этилиден-6-винилтетрагидро-2Н-пиран-2-она. Способ включает объединение δ-лактона со спиртом в органическом растворителе в присутствии каталитической системы, которая содержит палладий или его соль, с образованием реакционной смеси, которую нагревают при температуре от 110 до 130°С и давлении от 20 до 50 бар в течение от 3 до 5 часов в потоке газообразного монооксида углерода. Продукт реакции представляет собой замещенный 2-октендиоатный сложный диэфир. Спирт может представлять собой метиловый спирт, н-бутиловый спирт, 2-этилгексанол, изобутиловый спирт, изопропиловый спирт, бензиловый спирт или фенол. Растворитель может представлять собой толуол, ацетонитрил или тетрагидрофуран. Способ может включать добавление кислоты в реакционную смесь, которая может представлять собой разбавленную (приблизительно 5 мол.%) серную или п-толуолсульфоновую кислоту. Каталитическая ...

VERBINDUNGEN DES PHOSPHORS, ARSENS UND DES ANTIMONS BASIEREND AUF DIARYLANELLIERTEN BICYCLO[2.2.N]-GRUNDKÖRPERN UND DIESE ENTHALTENDE KATALYSATOREN

PREPARATION OF N-OCTADIENOL

MANUFACTURING PROCESS OF LAKTAT ESTER OR ACID

CYCLO-ALIPHATIC-AROMATIC DIPHOSPHINE AND YOUR USE IN THE CATALYSIS

CONNECTIONS of the PHOSPHORUS, ARSENIC AND the ANTIMONY BASED ON DIARYLANELLIERTEN BICYCLO (2.2.N) - BASES AND THESE CONTAINING CATALYSTS

NEW DIPHOSPHINE, THEIR COMPLEXES WITH TRANSITION METALS AND THEIR USE IN THE ASYMMETRICAL SYNTHESIS

PROCEDURE FOR THE PRODUCTION OF NEW DIPHOSPHINEN

CHIRALE PHOSPHIN AND/OR ARSINLIGANDEN ON METALLOCENBASIS

PARACYCLOPHANE

PROCEDURE FOR the PRODUCTION of SUBSTITUTED DIMETHYL (3-ARYL-BUTYL) - AMINE CONNECTIONS of MEANS of HOMOGENEOUS CATALYSIS

Synthesis of and hydroformylation with fluoro-substituted bi dentate phosphine ligands

METALLOCENE-BASED CHIRAL PHOSPHINE OR ARSINE LIGANDS

The present invention relates to metallocene-based phosphine ligands having chirality at phosphorus and at least one other element of chirality (planar chirality and/or chirality at carbon); and to the use of such ligands in asymmetric transformation reactions to generate high enantiomeric excesses of formed compounds. A method for the preparation of ligands according to the invention involving the conversion of the ortho-lithiated substituted metallocene to a phosphine chiral at phosphorus is also disclosed.

NOVEL DIPHOSPHINES, THEIR COMPLEXES WITH TRANSITION METALS AND THEIR USEIN ASYMMETRIC SYNTHESIS

The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): (see formula I) in which: - R1and R2 are a(C5-C7)cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and - A is (CH2-CH2) or CF2. The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).

PROCESS FOR THE TRANSITION METAL CATALYZED CYANATION OF ARYL/VINYL HALIDES

The present invention refers to a process for a transition metal, particularly nickel-catalyzed cyanation reaction of aryl/vinyl halide using organic nitrile compounds. This new reaction provides a strategically distinct approach to the safe preparation of aryl/vinyl cyanides, which are essential compounds in agrochemistry and medicinal chemistry.

PROCESS FOR PREPARING OPTICALLY ACTIVE CITRONELLAL

SYNTHESIS OF AND HYDROFORMYLATION WITH FLUORO-SUBSTITUTED BIDENTATE PHOSPHINE LIGANDS

PHOSPHACYCLE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

A PHOSPHA-ADAMANTANE (S) CATALYTIC SYSTEM

A catalyst system capable of catalysing the carbonylation of an olefinally unsaturated compound is described. The 5 catalyst system is obtainable by combining: (a) a metal of Group VIB or Group VIII B or a compound thereof; a nd (b) a bidentate phosphine of general formula (I) Ad) s (CR4R5R6) T Q2-A- (K, D) Ar (E, Z) -B-Q1 (Ad) u (CR1R2R3) v. Ad represents an optionally substitut ed adamantyl radical bonded to the phosphorous atom via any one of its tertiary carbon atoms. A method of production of the catalyst is also illustrated.</S DOAB>

ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH CYCLIC CHIRAL PHOSPHINE LIGANDS

The present invention relates to rigid chiral ligands useful in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed into catalysts to provide high selectivity of the enantiometric structure of the end-product.

New bis(phosphane oxide(s)) and macro:cyclic bis(phosphane(s))

L'invention concerne un procédé de préparation de bis(oxydes de phosphane) macrocycliques de formule: (CF DESSIN DANS BOPI) dans laquelle R1 , R2 , R3 et R4 sont des atomes d'hydrogène ou des groupes hydrocarbonés, éventuellement substitués, ou encore SO3 M1 / v avec M symbolisant un métal et v étant la valence du métal M, et R5 , R6 , R7 , R8 et Y sont des atomes d'hydrogène ou des groupes hydrocarbonés, éventuellement substitués, par réaction d'un di-anion macrocyclique avec deux équivalents d'un composé de formule X-Y-P(O)R7 R8 (III) où X est un groupe partant, ainsi que les bis(phosphanes) correspondants. On obtient ainsi des bis(oxydes de phosphanes) (I) utilisables pour l'extraction de lanthanides, d'actinides et de métaux alcalins et les bis(phosphanes) correspondants (V) utilisables pour la préparation de complexes de métaux de transition pour l'hydrogénation et/ou l'hydroformylation d'alcènes.

PROCEDE DE PREPARATION DE CITRONELLAL OPTIQUEMENT ACTIF

Procédé de préparation de citronellal optiquement actif caractérisé en ce que l'on hydrogène le néral ou le géranial en présence d'un catalyseur constitué par un complexe soluble dans le milieu réactionnel, formé à partir d'un dérivé du rhodium et d'une phosphine chirale. Ce procédé permet d'accéder au d-citronellal intermédiaire de la synthèse du (-) (1S) menthol.

COMPOSITION, PROCESS TO PREPARE THE SAME, CATALYSER, PROCESSES FOR THE HIDROFORMILAÇÃO, THE HIDROCIANETAÇÃO AND THE CARBONILAÇÃO OF COMPOSITION, THAT CONTAIN AT LEAST A DOUBLE LINKING ETILENICAMENTE INSATURADA, AND, USE OF A CATALYSER

A catalyst system

A catalyst system

The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: (a) a metal of Group VIB or Group VIIIB or a compound thereof, (b) a bidentate phosphine, arsine or stibine ligand, and (c) an acid, wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and that said acid is present in at least a 2:1 molar excess compared to said ligand, a process for the carbonylation of an ethylenically unsaturated compound, a reaction medium, and use of the system.

Rhodium complexes of asymmetric diphosphines, their preparation and their use

Optically active diphosphines of the formula: R1 CH2-CH-CH2-P ANGLE ¦¦R2 ¦¦ ¦¦R1' CH2-CH-CH2-P ANGLE R2' in which the phosphinomethyl groups are trans to each other, from rhodium complexes useful as catalysts in hydrogenating substituted acrylic acids and their esters to optically active propionic acid derivatives.

КАТАЛИТИЧЕСКАЯ СИСТЕМА

FIELD: chemistry. SUBSTANCE: present invention relates to a new catalyst system, a new carbonylation reaction medium and to a method of carbonylation of ethylene-unsaturated compounds using the new catalyst system. The catalyst system, which is capable of catalysing carbonylation of an ethylene-unsaturated compound, can be obtained by combining: a) group VIIIB metal, or its compound, b) bidentate phosphinic or arsinic ligand and c) acid, where the said ligand is present in molar excess of at least 2:1, compared to the said metal or said metal in its compound, and the said acid is present in molar excess ranging from 5:1 to 95:1, compared to the said ligand. In another version the catalyst system, which is capable of catalysing carbonylation of an ethylene-unsaturated compound, can be obtained by combining: a) group VIIIB metal, or its compound, b) bidentate phosphic or arsinic ligand and c) acid, where molar ratio of the said ligand to the said metal or said metal in its compound lies in the range greater than 5:1 to 750:1, and the said acid is present in molar excess of at least 2:1, compared to the said ligand. EFFECT: invention also relates to a method of carbonylation of an ethylene-unsaturated compound, a reaction medium, use of catalyst a system and a complex, which is capable of catalysing carbonylation of an ethylene-unsaturated compound. 39 cl, 35 ex, 9 tbl, 3 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 372 989 (13) C2 (51) МПК B01J B01J B01J C07C 31/24 (2006.01) 23/44 (2006.01) 23/74 (2006.01) 51/14 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2006133287/04, 17.02.2005 (24) Дата начала отсчета срока действия патента: 17.02.2005 (72) Автор(ы): ИСТХЭМ Грэхам (GB), ТИНДЭЙЛ Нил (GB) (43) Дата публикации заявки: 27.03.2008 2 3 7 2 9 8 9 (45) Опубликовано: 20.11.2009 Бюл. № 32 (56) Список документов, цитированных в отчете о поиске: US 2002/045748 A1, 18.04.2002. WO ...

СПОСОБ ГИДРОГЕНИЗАЦИИ ИМИНОВ И СПОСОБ ПОЛУЧЕНИЯ АМИНА

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes method of hydrogenation of imine with hydrogen under increased pressure and temperature in the presence of iridium catalyst in medium of inert solvent or without the latter, in the presence of ammonium chloride, bromide or iodide or metal chloride, bromide or iodide which are soluble in the reaction medium. Process is carried out in the presence of acid at temperature from minus 20 to 100 C using homogeneous catalyst as iridium catalyst corresponding to the formula [XJrYZ} (III), [XJrY] + A - (IIIa), [XJrZ 4 ] - M + (IIIb), [YJrHZ 2 ] 2 (IIIc), [YJrZ 3 ] 2 (IIId) where values X, Y and Z, A, M are given in p. 1 of the invention claim. Invention describes also method of synthesis of amine. EFFECT: increased catalytic activity and enantioselectivity, increased yield of optical isomer. 35 cl, 1 tbl, 40 ex УЭтОЗУЕС ПЧ Го (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ” 2 150 464 ' (51) МПК? 13) СЛ С 07С 209/26, 211/48, 231/10, 233/07 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 95122748/04, 21.01.1995 (24) Дата начала действия патента: 21.01.1995 (30) Приоритет: 02.02.1994 СН 309/94-0 (46) Дата публикации: 10.06.2000 (56) Ссылки: ЦЗ 5011995 А, 30.04.1991. 4$ 4994615 А, 19.02.1991. 9$ 410587ТА, 10.11.1987. ЕР 0077755 А2, 27.04.1983. ЕР 0006153 АЛ, 08.01.1980. ЕР 0115470 АЛ, 08.08.1984. МО 96/41793 АЛ, 27.12.1996. ЗЦ 743561 А, 25.06.1980. $Ц 622397 А, 30.08.1918. Химическая энциклопедия. - М.: Большая Российская энцикпопедия, 1988, т. 1, с. 112. ВЕЙГАНД-ХЕЛЬГЕТАГ. Методы эксперимента в органической химии. - М.: Химия, 1968, с. 470. СЬЮЛЛЕР, Д.ПИРСОН. Органические синтезы. - М.: Мир, ч.П.с. 573. (85) Дата перевода заявки РСТ на национальную фазу: 02.11.1995 (86) Заявка РСТ: ЕР 95/00221 (21.01.1995) (87) Публикация РСТ: М/О 95/21151 (10.08.1995) (98) Адрес для переписки: 101000, Москва, пер. Малый Златоустинский 10, кв.15, "ЕВРОМАРКПАТ", Веселицкой И.А. (71) ...

Hydroformylation of olefinic compounds

In hydroformylating an olefinic compound in an organic solvent and in the presence of a rhodium complex and a trisubstituted phosphine to give the corresponding aldehyde, at least one diphosphino compound of the following general formula (I) is added to the reaction system in a proportion of 0.20 to 5.0 equivalents per rhodium atom in the rhodium complex (I) wherein A1 and A2, respectively, are aryl groups; R1 and R2, respectively, are an aryl group or a saturated hydrocarbon residue containing 1 or more carbon atoms; and represents a substituted or unsubstituted alicyclic hydrocarbon group containing 3 to 6 carbon atoms in the main ring. The addition of diphosphino compound (I) has a remarkable life-prolonging effect on the rhodium catalyst.

Process for the production of asymmetric transformation catalysts

PROCEDURE FOR THE PRODUCTION OF KATIONI RHODIUM COMPLEXES

CARBONYLIERUNGSVERFAHREN FROM ETHYLENISCHUNGESÄTTIGTEN CONNECTIONS

A ADAMANTYL ABSTENTION CATALYST SYSTEM

PROCEDURE FOR THE HYDROGENATION OF IMINEN

SEPARATION PROCEDURE

NEW ONE DIPHOSPHINVERBINDUNG, INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, TRANSITION METAL COMPLEX CONTAINING THE CONNECTION AS LIGAND AND CATALYST FOR ASYMMETRICAL HYDROGENATIONS, OF WHICH CONTAINS THE COMPLEX

CHIRAL METAL COMPLEXES THEREOF DIPHENYLDIPHOSPHINE AND D -8

IMPROVED SEPARATION PROCESSES

This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a polar solvent and said one or more products, wherein said process comprises (1) mixing said reaction product fluid with a nonpolar solvent to obtain by phase separation a polar phase comprising said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and said polar solvent and nonpolar phase comprising said one or more products and nonpolar solvent, and (2) recovering said nonpolar phase from said polar phase; wherein said organophosphorus ligand has a partition coefficient between the polar solvent and the nonpolar solvent of greater than about 10, and said one or more products have a partition coefficient between the nonpolar solvent and the polar solvent of greater than about 0.5.

SYNTHESIS OF OPEN METAL CARBONYL CLUSTERS

The present invention is directed to the synthesis of novel stable open metal clusters by selective oxidation of bound ligands. The synthesis comprises, for example, using an amine based oxidant for decarbonylation of specific carbonyl ligands. The synthesis can also comprise further removal of a bound amine group by an acid. The resulting metal cluster contains a coordinatively unsaturated site comprising a carbonyl vacancy. The resulting metal cluster can be used as a catalyst in a variety of chemical transformations.

IMPROVED SEPARATION PROCESSES

This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a polar solvent and said one or more products, wherein said process comprises (1) mixing said reaction product fluid with a nonpolar solvent to obtain by phase separation a polar phase comprising said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and said polar solvent and nonpolar phase comprising said one or more products and nonpolar solvent, and (2) recovering said nonpolar phase from said polar phase; wherein said organophosphorus ligand has a partition coefficient between the polar solvent and the nonpolar solvent of greater than about 10, and said one or more products have a partition coefficient between the nonpolar solvent and the polar solvent of greater than about 0.5.

CHIRAL DIPHENYLDIPHOSPHINES AND D-8 METAL COMPLEXES THEREOF

Compounds of formula III, (see formula III) wherein R6 and R7 signify identical or different secondary phosphino; R8 is CH2-OH, -CH2-NH2, -CH2-O-B-FU, -CH2-NH2-B-FU, or -O-B-FU; R9 has the same significance as R8 or is C1-C4-alkyl or C1-C4-alkoxy; or R8 and R9 together signify HOCH(CH2-O-)2, H2NCH-(CH2-O-)2, FU-B-OCH(CH2-O-)2 or FU-B-HNCH(CH2-O-)2; B is a bridging group; and FU is a functional group. The compounds may be bonded to inorganic or organic carriers. Their d-8 metal complexes are valuable catalysts for the enantioselective hydrogenation of prochiral organic compounds with carbon multiple bonds or carbon/hetero atom multiple bonds.

촉매 가역적 알켄-니트릴 상호전환 방법

... 본 발명은 제어가능한 HCN-불포함 전이 히드로시안화를 통한 촉매 가역적 알켄-니트릴 상호전환 방법에 관한 것이다.

catalisadores seletivos para produção de uma mistura de di-hidro-et-j e et-l

BIDENTATE PHOSPHINE LIGAND

The invention relates to a bidentate phosphine ligand, the phosphorous atoms of the phosphine being connected via a bridge group, the bridge group of the bidentate phosphine ligand consisting of an ortho-anellated annular system, comprising two aryl groups, which aryl groups are connected by two bridges, the first bridge consisting of an -O- or an -S- atom and the second bridge being a group that contains an oxygen, sulphur, nitrogen, silicon or carbon atom or a combination of these atoms, the two phosphorous atoms being connected to the two aryl groups of the bridge group at the ortho-position relative to the -O- or -S- atom of the first bridge. The invention also relates to the use of this bidentate phosphium ligand in a catalyst system comprising also a transition metal compound which is used in the following type of reactions: hydroformylation, hydrogenation, hydrocyanation, polymerization, isomerisation, carboxylation, cross coupling and metathesis.

IRIDIUM-DIPHOSPHINE COMPLEXES AND PROCESS FOR THE HYDROGENATION OF IMINES

Compounds of formulae I: (DIP)IrXqYr(Z), Ia: (DIP)IrXsYt(Z)2 and Ib: (DIP)Ir(Z)3 or mixtures of at least two of those compounds, wherein DIP is a ditertiary diphosphine, the two phosphine groups of which are bonded to a C2-, C3- or C4-carbon chain, with the result that the diphosphine forms a 5- to 7-membered ring together with the Ir atom, X is Cl, Br or I, Y is a hydrogen atom, q and r are 0, 1 or 2 and the sum of q+r is 2, s and t are 0 or 1 and the sum of s+t is 1, and Z is the anion of an organic oxy acid that contains a group C(=O)O, S(=O)O or P(=O)O in the anion. The compounds are excellent catalysts for the hydrogenation of imines, especially for the enantioselective hydrogenation of prochiral imines.

CHIRAL PHOSPHINES, TRANSITION METAL COMPLEXES THEREOF AND USES THEREOF IN ASYMMETRIC REACTIONS

L'invention concerne des ligands chiraux et des complexes de métaux de transition formés avec ces ligands chiraux, qui sont utiles dans la catalyse des réactions asymétriques. Ces ligands chiraux comprennent (R,S,S,R)-DIOP*. Le complexe ruthénium réduit l'énamide en amine correspondante avec une énantiosélectivité pouvant atteindre 99 %. Les complexes de métaux de transition de ces ligands chiraux sont utiles dans les réactions asymétriques telles que l'hydrogénation, le transfert d'hydrure, l'hydrosilylation, l'hydroboration, l'hydrovinylation, l'hydroformylation, l'hydrocarboxylation, l'isomérisation, l'alkylation allylique, la cyclopropanation, la réaction de Diels-Alder, la réaction de Heck, l'isomérisation, la réaction d'aldol, l'addition de Michael et les réactions d'époxidation asymétriques.

Synthesis of and hydroformylation with fluoro-substituted bidentate phosphine ligands

Hydroformylation of alkenes to aldehydes in the presence of a rhodium complex catalyst is improved by the addition of a novel bidentate ligand of the formula wherein R1, R2, R1' and R2' are organic radicals selected from alicyclic, aliphatic and aromatic groups of which at least one is preferably substituted with at least one electronegative moiety and the methylene groups are present at the trans-2,3 positions on the norbornane moiety. The invention also provides a novel method for producing the bidentate ligand and novel intermediate phosphine oxide and phosphinous acid compounds.

Phosphine azacrown ether compounds

Phosphine azacrown ethers and complexes thereof with selected cations as promoters for hydroformylation catalysts; adducts of said promoters with selected hydroformylation catalysts; process for making the promoters; and process for hydroformylation.

Novel Compound, Novel Ligand, Novel Transition Metal Complex, and Catalyst Including Novel Transition Metal Complex

The invention provides novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. A ligand of the invention includes a compound represented by General Formula (1): RRRA or General Formula (2): RRA-Y-ARRand having a total of 15 to 110 carbon atoms. In the formulae, A is phosphorus or arsenic; R, R, Rand Rare each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene. 1. A compound represented by General Formula (1) or (2) and having a total of 15 to 110 carbon atoms:{'br': None, 'sup': 1', '2', '3, 'RRRA\u2003\u2003(1)'}{'br': None, 'sup': 1', '2', '3', '4, 'RRA-Y-ARR\u2003\u2003(2)'}{'sup': 1', '2', '3', '4, 'sub': '2-20', '(wherein A is phosphorus or arsenic; R, R, Rand Rare each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene).'}2. The compound according to claim 1 , wherein the electron-withdrawing group is at least one selected from the group consisting of a perhaloalkyl group having 1 to 4 carbon atoms claim 1 , a halogen claim 1 , nitro group claim 1 , cyano group claim 1 , pentafluorophenyl group claim 1 , tetrafluoropyridyl group claim 1 , heptafluorotolyl group claim 1 , 2 claim 1 ,6- ...

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

PROCESS FOR THE CATALYTIC REVERSIBLE ALKENE-NITRILE INTERCONVERSION

The present invention refers to processes for catalytic reversible alkene-nitrile interconversion through controllable HCN-free transfer hydrocyanation. 2. Process according to claim 1 , wherein R claim 1 , R claim 1 , Rand Rcan be the same or different and each independently represents H claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl claim 1 , each being optionally substituted by one or more groups selected from straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent claim 1 , or a heterosubstituent claim 1 , or Rand Rform a bond; wherein at least one of R claim 1 , R claim 1 , Rand Ris not hydrogen.3. Process according to claim 1 , wherein R claim 1 , R claim 1 , Rand Rcan be the same or different and each independently represents H claim 1 , straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , each being optionally substituted by one or more groups selected from straight chain or branched chain alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent claim 1 , or a heterosubstituent claim 1 , or at least two of R claim 1 , R claim 1 , Rand Rmay each form a cyclic 3 to 20 membered hydrocarbon ring structure which may further be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , aryl claim 1 , heteroaryl or heterosubstituent claim 1 , and optionally having any of O claim 1 , S claim 1 , N in the straight chain claim 1 , branched chain or cyclic structure claim 1 , wherein optionally at least one of R claim 1 , R claim 1 , Rand Ris not hydrogen.4. Process according to claim 3 , wherein R claim 3 , R claim 3 , Rand Rcan be the same or ...

IMMOBILIZED CATALYTICALLY ACTIVE COMPOSITION FOR HYDROFORMYLATION OF OLEFIN-CONTAINING MIXTURES

A composition and the use of said composition as catalytically active composition in processes for synthesis of chemical compounds, especially the hydroformylation of olefinically unsaturated hydrocarbon mixtures. 1. A composition comprising:a) at least one inert porous support material;b) at least one metal selected from the eighth transition group of the Periodic Table of the Elements;c) at least one organic phosphorus compound; andd) at least one high-boiling liquid on the inert porous support material, having a lower vapour pressure than 0.074 MPa at 100° C. and 1.0 MPa,wherein the composition is free of ionic liquids.2. The composition as claimed in claim 1 , i) mean pore diameter within a range from 1 to 430 nm;', 'ii) pore volume within a range from 0.1 to 2 ml/g; and', {'sup': '2', 'iii) BET surface area within a range from 10 to 2050 m/g.'}], 'wherein the inert porous support material has the following material properties3. The composition as claimed in claim 1 ,wherein the organic phosphorus compounds are phosphines, phosphites and/or phosphoramidites.5. The composition as claimed in claim 1 , wherein the high-boiling liquid is formed in situ during use in a process for chemical synthesis.6. The composition as claimed in claim 5 , wherein the high-boiling liquid is formed in situ during the hydroformylation of olefin-containing hydrocarbon mixtures.7. A process for hydroformylating olefin-containing hydrocarbon mixtures claim 5 , comprising:a) introducing an olefin-containing hydrocarbon mixture into a reaction mixture,b) introducing an inert porous support material into the reaction mixture,c) introducing at least one metal selected from the group consisting of cobalt, rhodium, iridium and ruthenium into the reaction mixture,d) introducing at least one organic phosphorus compound selected from the group consisting of phosphines, phosphites and phosphoramidites into the reaction mixture,e) introducing an aldol compound which is not part of the olefin- ...

PROCESS FOR OLIGOMERIZATION

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound. 2. The process of wherein the olefin comprises ethylene and the product comprises a mixture of 1-octene and 1-hexene in a weight fraction ranging from 85 percent by weight to 100 percent by weight of total product formed.3. The process of wherein the catalyst system is prepared by combining a) the source of chromium claim 1 , b) one or more activators claim 1 , and c) at least one phosphacycle-containing ligating compound together in any order.4. The process of comprising contacting a feed stream with the catalyst system wherein the feed stream comprises the olefin.5. The process of claim 1 , wherein the source of chromium is selected from the group consisting of trichlorotris(tetrahydrofuran)chromium claim 1 , chromium (III) acetylacetonate claim 1 , chromium (III) 2-ethylhexanoate claim 1 , and chromium (III) acetate.6. The process of claim 1 , wherein the source of chromium and the ligating compound are contacted in proportions to provide Cr:ligating compound ratios from 1000:1 to 1:1000.7. The process of claim 1 , wherein the catalyst system further includes an activator selected from the group consisting of (hydrocarbyl)aluminum compounds claim 1 , (hydrocarbyl)gallium compounds claim 1 , (hydrocarbyl)boron compounds claim 1 , (hydrocarbyl)zinc compounds claim 1 , non-coordinating claim 1 , ion-forming compounds claim 1 , an organic salt claim 1 , an inorganic acid and salt.8. The process of claim 7 , wherein the activator is an alkylaluminoxane.9. The process of claim 8 , wherein the source of chromium and the aluminoxane are combined in proportions to provide chromium: ...

PROCESS FOR OLIGOMERIZATION

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound. 2. The process of wherein the olefin comprises ethylene and the product comprises a mixture of 1-octene and 1-hexene in a weight fraction ranging from 85 percent by weight to 100 percent by weight of total product formed.3. The process of wherein the catalyst system is prepared by combining a) the source of chromium claim 1 , b) one or more activators claim 1 , and c) at least one phosphacycle-containing ligating compound together in any order.4. The process of comprising contacting a feed stream with the catalyst system wherein the feed stream comprises the olefin.5. The process of claim 1 , wherein the source of chromium is selected from the group consisting of trichlorotris(tetrahydrofuran)chromium claim 1 , chromium (III) acetylacetonate claim 1 , chromium (III) 2-ethylhexanoate claim 1 , and chromium (III) acetate.6. The process of claim 1 , wherein the source of chromium and the ligating compound are contacted in proportions to provide Cr:ligating compound ratios from 1000:1 to 1:1000.7. The process of claim 1 , wherein the catalyst system further includes an activator selected from the group consisting of (hydrocarbyl)aluminum compounds claim 1 , (hydrocarbyl)gallium compounds claim 1 , (hydrocarbyl)boron compounds claim 1 , (hydrocarbyl)zinc compounds claim 1 , non-coordinating claim 1 , ion-forming compounds claim 1 , an organic salt claim 1 , an inorganic acid and salt.8. The process of claim 7 , wherein the activator is an alkylaluminoxane.9. The process of claim 8 , wherein the source of chromium and the aluminoxane are combined in proportions to provide chromium: ...

ARYL PHOSPHINES WITH FUSED RING ORTHO-ALKOXY SUBSTITUTION

An aryl phosphine with fused ring ortho-alkoxy substitution that includes an aryl monophosphine and an aryl bi-sphosphme. 2. The aryl phosphine of claim 1 , wherein Rand Rare independently selected from the group consisting of methyl claim 1 , ethyl claim 1 , n-propyl claim 1 , isopropyl claim 1 , n-butyl claim 1 , sec-butyl claim 1 , isobutyl claim 1 , t-butyl claim 1 , adamantyl claim 1 , phenyl claim 1 , biphenyl claim 1 , and cyclohexyl.3. The aryl phosphine of claim 1 , where Rand Rtogether with the phosphorus atom form a 5- claim 1 , 6- claim 1 , or 7-membered ring.10. The aryl phosphine of claim 1 , where the aryl phosphine is a ligand for a transition metal selected from the group consisting of titanium (Ti) claim 1 , copper (Cu) claim 1 , palladium (Pd) claim 1 , cobalt (Co) claim 1 , rhodium (Rh) claim 1 , ruthenium (Ru) claim 1 , chromium (Cr) and platinum (Pt).11. (canceled) This disclosure relates to aryl phosphines with fused ring ortho-alkoxy substitution.Phosphorous (P) containing compounds are ligands for a variety of transition metals, including, but not limited to titanium (Ti), copper (Cu), palladium (Pd), cobalt (Co), rhodium (Rh), ruthenium (Ru), chromium (Cr) and platinum (Pt). In particular, P containing compounds, such as aryl phosphines, which include a P atom covalently bonded to an aryl ring, are ligands for a variety of transition metal catalyzed reactions. These transition metal catalyzed reactions can include hydrogenations, ethylene carbon monoxide copolymerizations, butadiene telomerization, hydroformylation, metal (e.g., Pd) catalyzed cross coupling (e.g., Suzuki reactions, Buchwald-Hartwig coupling reactions), methoxycarbonylation of olefins, ethylene oligomerization, and olefin polymerization.When an aryl phosphine is used as a ligand for one of these transition metal catalyzed reactions, the electronic and steric environment around the transition metal catalyst can be changed by varying the substituents on the aryl ring of the ...

Method for producing a spirooxindole derivative

The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

CHROMIUM COMPLEX AND CATALYST THEREFROM

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound. 110-. (canceled)121. The catalyst system as in claim comprising a phosphacycle-containing ligating compound-chromium complex.131. The catalyst system as in claim comprising an isolated phosphacycle-containing ligating compound-chromium complex.141. The catalyst system as in claim comprising an in situ-formed phosphacycle-containing ligating compound-chromium complex.151. The catalyst system of claim , wherein the source of chromium is selected from the group consisting of trichlorotris(tetrahydrofuran)chromium , chromium (III) acetylacetonate , chromium (III) 2-ethylhexanoate , and chromium (III) acetate.161. The catalyst system of claim , wherein the source of chromium and the ligating compound are contacted in proportions to provide Cr:ligating compound ratios from 1000:1 to 1:1000.171. The catalyst system of claim , wherein at least one activator is selected from the group consisting of (hydrocarbyl)aluminum compounds , (hydrocarbyl)gallium compounds , (hydrocarbyl)boron compounds , (hydrocarbyl)zinc compounds , non-coordinating , ion-forming compounds , an organic salt , an inorganic acid and salt , Brønsted acid salts , salts of a cationic oxidizing agent and a non-coordinating , compatible anion , carbenium salts , and silylium salts.181. The catalyst system of claim , wherein the activator is an alkylaluminoxane.191. The catalyst system of claim , wherein the source of chromium and the aluminoxane are combined in proportions to provide chromium:activator molar ratios from 1:1 to 1:10 ,000. This application is a Divisional of U.S. National Stage application Ser. No. 15/ ...

Process for the Preparation of Olaparib and Intermediates Thereof

The present invention provides processes for the preparation of intermediate compounds of formulas (4) and (5) useful in the preparation of Olaparib. 2. The process of wherein the reaction of the compound of Formula (4) with hydrazine occurs in the presence of a metal hydroxide base.4. The process of wherein X is bromide.5. The process of wherein the alkali metal alkoxide is sodium methoxide claim 4 , sodium ethoxide or mixtures thereof.6. The process of wherein the compound of formula RCOR′ is selected from the group consisting of methyl formate claim 5 , ethyl acetate claim 5 , isopropyl acetate claim 5 , methyl propionate claim 5 , ethyl propionate claim 5 , ethyl butyrate and mixtures thereof.7. The process of wherein the compound of formula RCOR′ is ethyl propionate.10. The process of wherein the reaction of step (a) occurs in the presence of a metal hydroxide base.13. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium.14. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium and the ligand is Xantphos.16. The process of wherein X is bromide.17. The process of wherein the reaction of step (i) occurs in the presence of a metal hydroxide base.19. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium.20. The process of wherein the transition metal catalyst is bis(dibenzylideneacetone)palladium and the ligand is Xantphos. This application claims priority to U.S. Provisional Patent Application No. 62/294,366 filed Feb. 12, 2016, the disclosure of which is hereby incorporated in its entirety by reference.The present invention relates to the field of synthesis of organic compounds and, in particular, to the synthesis of intermediates useful in the preparation of Olaparib.Olaparib (4-[(3-{([4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorophenyl)methyl]phthalazin-1(2H)one), is indicated for the treatment of germline BRCA-mutated advanced ovarian ...

Selective catalysts for spinetoram production

This invention is based on the discovery that homogeneous catalysts, [Rh(C 2 H 4 ) 2 Cl] 2 and/or [Rh(COD) 2 ][BF 4 ], can be used to produce spinetoram in higher yields at lower catalyst loadings as compared to previous methodologies. In addition, one or more phosphorus ligand donors can also be added to further increase yields/efficiency. The methods and/or systems provided herein enable cost-effective ways to produce spinetoram in large quantity with relatively simple procedures.

METAL-CATALYZED ALKOXYCARBONYLATION OF A LACTONE

The metal-catalyzed alkoxycarbonylation of a lactone is a method of alkoxycarbonylating a δ-lactone, specifically 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one. The method includes combining the δ-lactone with an alcohol in an organic solvent in the presence of a catalyst system that includes palladium or a salt thereof to form a reaction mixture, which is heated to 110-130° C. at a pressure of 20-50 bar for between 3-5 hours under flow of carbon monoxide gas. The product of the reaction is a substituted 2-octendioate diester. The alcohol may be methyl alcohol, n-butyl alcohol, 2-ethylhexanol, isobutyl alcohol, isopropyl alcohol, benzyl alcohol, or phenol. The solvent may be toluene, acetonitrile, or tetrahydrofuran. The method may include adding an acid to the reaction mixture, which may be dilute (about 5 mol %) sulfuric or p-toluenesulfonic acid. The catalyst system may also include a phosphine ligand. 1. A method for metal-catalyzed alkoxycarbonylation of a δ-lactone , the δ-lactone being 3-ethylidene-6-vinyletetrahydro-2H-pyran-2-one , the method comprising the steps of:adding an alcohol and a catalyst system including palladium or a salt thereof to a solution of the δ-lactone in an organic solvent to form a reaction mixture;placing the reaction mixture under pressure of carbon monoxide (CO) gas;heating the reaction mixture to a temperature of at least 110° C.; andrecovering a 2-octendioate diester product.2. The method for metal-catalyzed alkoxycarbonylation according to claim 1 , wherein the catalyst system further comprises a phosphine ligand.3. The method for metal-catalyzed alkoxycarbonylation according to claim 2 , wherein the phosphine ligand is selected from the group of phosphine ligands having the formulas shown in L1 claim 2 , L2 claim 2 , L3 claim 2 , L4 claim 2 , L5 claim 2 , L6 claim 2 , L7 claim 2 , L8 claim 2 , L9 claim 2 , L10 claim 2 , L11 claim 2 , L12 claim 2 , L13 claim 2 , L14 claim 2 , L15 claim 2 , L16 claim 2 , L17 claim 2 , L18 claim 2 ...

Oxidative Dehydroxymethylation of Alcohols to Produce Olefins

Catalyst compositions for the conversion of aldehyde compounds and primary alcohol compounds to olefins are disclosed herein. Reactions include oxidative dehydroxymethylation processes and oxidative dehydroformylation methods, which are beneficially conducted in the presence of a sacrificial acceptor of Hgas, such as N,N-dimethylacrylamide. 1. A catalyst composition comprising:a Group VIII metal compound;(ii) a heteroatomic ligand compound;(iii) a Bronsted acid compound; and(iv) an acceptor comprising an α,β-unsaturated compound.2. The catalyst composition of claim 1 , wherein the acceptor comprises an α claim 1 ,β-unsaturated ketone claim 1 , an α claim 1 ,β-unsaturated amide claim 1 , an α claim 1 ,β-unsaturated thioester claim 1 , or any combination thereof.3. The catalyst composition of claim 1 , wherein the acceptor comprises methyl vinyl ketone claim 1 , acrylonitrile claim 1 , ethyl acrylate claim 1 , t-butyl acrylate claim 1 , acrylamide claim 1 , dimethylacrylamide claim 1 , or any combination thereof.4. The catalyst composition of claim 1 , wherein the acceptor comprises dimethylacrylamide.5. The catalyst composition of claim 1 , wherein:{'sub': '2', 'the acceptor is capable of being reduced by an equivalent of H; and'}the acceptor is capable of coordinating to the metal compound.6. The catalyst composition of claim 1 , wherein:the metal compound comprises a rhodium compound, a cobalt compound, an iridium compound, or a combination thereof;the heteroatomic ligand compound comprises a phosphine donor group, an amine donor group, a sulfide donor group, or any combination thereof; andthe Bronsted acid compound is a carboxylic acid.7. The catalyst composition of claim 1 , wherein:{'sub': '2', 'the metal compound is [Rh(cod)OMe];'}the heteroatomic ligand compound is Xantphos; andthe Bronsted acid compound is 3-methoxybenzoic acid.8. The catalyst composition of claim 1 , wherein:a molar ratio of the metal compound to the heteroatomic ligand compound is in a ...

Phosphacycle compound and process for production thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

CATALYST, HYDROGENATION OF HYDROGEN CARBONATE, HYDROGEN STORAGE SYSTEM

The invention relates to a catalyst according to the formula IrCl(cod)(NHC)]+nP (n=2, 3 or 4), or [Ir(cod)(NHC)(P)]+nP (n=1, 2 or 3), which is suitable to decompose formates in an aqueous reaction system, and for the production of hydrogen gas free of COor hydrogenation of hydrogen carbonates, wherein Ir means iridium; Cl means chloro; cod means 1,5-cyclooctadiene; NHC means N-heterocyclic carbene, preferably 1-R-3-methylimidasolium chloride, wherein R means C1 to C5 alkyl and P means 1,3,5-triaza-7-phosphaadamantane (pta), monosulphonated triphenilphosphine (mtppms), trisulphonated triphenylphosphine (mtppts), or tetrasulphonated diphenylphosphynopropane (dpppts). Furthermore, the invention relates to a process for the preparation of the catalyst according to the invention. Further, the invention relates to a process for the decomposition of formate in aqueous reaction system, and for the production of hydrogen gas free of CO, still further, a process for the hydrogenation of hydrogen carbonate in an aqueous reaction system, as well as the production of the respective formate. Further, the invention relates to a process for the decomposition of formate according to the invention, and the hydrogenation of the hydrogen carbonate generated in the same reaction system. The invention relates to a hydrogen storage system based on the process according to the invention, preferably accumulator or fuel cell, and the use thereof. 1. A catalyst according to the general formula of [IrCl(cod)(NHC)]+nP , which is suitable for the decomposition of formates in an aqueous reaction system and for the generation of hydrogen gas (H) , which is free of COside products , or for the hydrogenation of hydrogen carbonates (HCO) , wherein in the formulaIr means iridium;Cl means chloro;cod means 1,5-cyclooctadiene;NHC means an N-heterocyclic carbene, preferably 1-R-3-methylimidazolium chloride, wherein R means C1 to C5 alkyl group, preferably C2 or C4 alkyl group;n means an integer with the ...

CATALYST SYSTEM

The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: 137-. (canceled)38. A process for the carbonylation of an ethylenically unsaturated compound comprising an ethylenically unsaturated compound with carbon monoxide and a hydroxyl group containing compound in the presence of a catalyst system , which system is obtained by combining:a) a metal of Group VIB or Group VIIIB or a compound thereof,b) a bidentate phosphine, arsine, or stibine ligand, andc) an acid,wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and said acid is present in at least a 2:1 molar excess compared to said ligand.39. A process as claimed in wherein the ratio of said ligand to said metal is in the range 5:1 to 750:1.40. A process as claimed in wherein the ratio of said ligand to said metal is in the range 10:1 to 500:1.41. A process as claimed in wherein the ratio of said ligand to said metal is in the range 20:1 to 40:1.42. A process as claimed in wherein the ratio of said acid to said ligand is in the range 20:1 to 40:1.43. A process as claimed in wherein the molar ratio of said acid to said metal is in the range 10:1 to 75000:1.44. A process as claimed in wherein the molar ratio of said acid to said metal is in the range 100:1 to 25000:1.45. A process as claimed in wherein the molar ratio of said acid to said metal is in the range 200:1 to 400:1.46. A process as claimed in wherein said ligand is a bidentate phosphine ligand.48. A process as claimed in wherein Rto Reach independently represent lower alkyl claim 47 , aryl claim 47 , or Het.49. A process as claimed in wherein said ligand is represented as:{'br': None, 'sub': S', 'T', 'u', 'v, 'sup': 7', '8', '9', '2', '1', '1', '2', '3, '(Ad)(CRRR)Q-A-(K,D)Ar(E,Z)—B-Q(Ad)(CRRR),'}{'sup': 3', '13', '14', '15, 'sub': w', 'x, 'wherein K, D, E and Z may ...

PROCESS FOR THE TRANSITION METAL CATALYZED CYANATION OF ARYL/VINYL HALIDES

The present invention refers to a process for a transition metal, particularly nickel-catalyzed cyanation reaction of aryl/vinyl halide using organic nitrile compounds. This new reaction provides a strategically distinct approach to the safe preparation of aryl/vinyl cyanides, which are essential compounds in agrochemistry and medicinal chemistry. 2. Process according to wherein Rrepresents a Cto Chydrocarbon chain which forms a five to eight-membered optionally substituted hydrocarbon ring system with the vinyl moiety which ring system may be a cycloalkyl claim 1 , heterocycloalkyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl or heteroaralkyl hydrocarbon claim 1 , which may be part of a hydrocarbon ring system having up to 30 carbon atoms and which may optionally be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent.3. Process according to wherein Rrepresents a Cto Chydrocarbon chain which forms a five to six membered optionally substituted aromatic or heteroaromatic hydrocarbon ring system with the vinyl moiety claim 1 , which may be part of a hydrocarbon ring system having up to 30 carbon atoms and which may optionally be substituted by one or more groups selected from alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , aryl claim 1 , aralkyl claim 1 , heteroaryl claim 1 , heteroaralkyl or a heterosubstituent.4. Process according to wherein Ris a Rrepresents a straight chain Cto Calkyl group.5. Process according to claim 1 , wherein the coordinated transition metal catalyst is obtained from a transition metal catalyst precursor selected from Ni(COD) claim 1 , Ni(acac) claim 1 , Ni(CO) claim 1 , Pd(dba) claim 1 , Pd(OAc) claim 1 , Co(CO).6. Process according to wherein the ligand of the coordinated transition metal catalyst ...

WATER-INSOLUBLE RUTHENIUM CATALYST COMPOSITION FOR USE IN AQUEOUS HYDROGENATION REACTIONS

The invention relates to a method for converting a precatalyst complex to an active catalyst complex, wherein the precatalyst complex and the active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, and the active catalyst complex furthermore comprises a monohydride and a water molecule. The method comprises the steps of providing water as an activation solvent system with a pH value equal or below 2, and solving said precatalyst complex, an acid, and hydrogen therein. The invention further relates to a method for manufacturing a catalyst composition, a method for hydrogenating a substrate molecule and a reaction mixture. 1. A method for obtaining a catalyst composition , comprising the steps ofa) providing water as a preparation solvent system, and a first catalyst composition comprising an optically inactive ligand and a ruthenium metal atom,', 'an optically active ligand, wherein said optically active ligand is insoluble in water,', 'a preparation surfactant that is capable of forming micelles in water and that is resistant to hydrolysis at pH≦2, and', 'an acid,', 'thereby yielding a second catalyst composition comprising said ruthenium atom and said optically active ligand,, 'b) adding to, particularly solving in, said preparation solvent system'}characterized in thatthe pH value of said preparation solvent system is equal or below 2 after addition of said acid.2. The method according to claim 1 , wherein said preparation solvent system comprises ≧25% (v/v) claim 1 , ≧50% (v/v) claim 1 , ≧75% (v/v) claim 1 , ≧80% (v/v) claim 1 , ≧90% (v/v) claim 1 , ≧99% (v/v) or 100% water.3. The method according to claim 1 , wherein said preparation surfactant is non-ionic claim 1 , particularly an alkylglycoside.4. The method according to claim 1 , wherein said preparation surfactant is D-glycopyranoside C9-C11 alkyl.7. The method according to wherein said reaction surfactant is non-ionic surfactant claim 6 , particularly an ...

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Olefin oligomerization process with a catalyst comprising a chromium complex with a phosphacycle-containing ligand

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound.

Process for the carbonylation of ethylenically unsaturated compouds

A process for the carbonylation of ethylenically unsaturated compounds is described. The process comprises reacting an ethylenically unsaturated compound with carbon monoxide in the presence of a source of hydroxyl groups and a catalyst system. The catalyst system is obtained by combining: (a) metal of Group VIII or a compound thereof: and (b) a bidentate phosphine of general formula (I) The carbonylation reaction is carried out at a temperature of between -30°C to 49°C and under a CO partial pressure of less than 30 x105 N.m-2.

A catalyst system

The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: a) a metal of Group VIB or Group VIIIB or a compound thereof, b) a bidentate phosphine, arsine or stibine ligand, and c) an acid, wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and that said acid is present in at least a 2:1 molar excess compared to said ligand, a process for the carbonylation of an ethylenically unsaturated compound, a reaction medium, and use of the system.

Phosphacycle-containing ligand for chromium complex and olefin oligomerisation catalyst therefrom

The present invention relates to a composition comprising a phosphacycle-containing ligating compound represented as: wherein: P is phosphorus; X 1 is phosphorus; each of R 1 and R 2 is independently a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; m is 1; R 1 and R 2 are linked together to form a divalent moiety represented as which together with P forms a cyclic structure (phosphacycle) containing from 3 to 10 ring atoms; each of R 3 and R 4 is independently hydrogen, halogen, a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; R 3 and R 4 are optionally linked together to form a divalent moiety represented as wherein the optional character of the linkage is depicted by a dashed connection, which together with X 1 forms a cyclic structure containing from 3 to 10 ring atoms; Y is a divalent linking group [L(R 5 ) q ] p between P and X 1 containing from one to 50 non-hydrogen atoms; [L(R 5 ) q ] p is represented by: wherein each L is independently selected from the group consisting of nitrogen; p is an integer number from 1 to 6; R 5 is independently hydrogen, halogen, substituted or unsubstituted hydrocarbon derivative, substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group; q is 0, 1, or 2; provided that the [L] p subunit of the divalent linking group [L(R 5 ) q ] p does not comprise an amidine (N-C=N) group; further provided that in at least one phosphacycle of the phosphacycle-containing ligating compound, both atoms directly bonded to P or X 1 are sp 3 hybridized; still further provided that one or two phosphacycles comprising P, R 1 , and R 2 , or comprising X 1 , R 3 , and R 4 , contain no P-N, ...

Chromium complex with a phosphacycle-containing ligand and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound.

Catalyst, hydrogenation of hydrogen carbonate, hydrogen storage system

The invention relates to a catalyst according to the formula lrCI(cod)(NHC)] + nP (n = 2, 3 or 4), or [lr(cod)(NHC)(P)] + nP (n = 1, 2 or 3), which is suitable to decompose formates in an aqueous reaction system, and for the production of hydrogen gas or hydrogenation of carbonates, wherein Ir means irydium; CI means chlorine; cod means 1,5-cyclooctadiene; NHC means N-heterocyclic carbene, preferably 1-R-3-methylimidasolium chloride, wherein R means C 1-5 alkyl es P means 1,3,5-triaza-7-phosphaadamantane (pta), monosulphonated triphenilphosphine ( m tppms), trisulphonated triphenylphosphine ( m tppts), or four times sulphonated diphenylphosphynopropane (dpppts). Furthermore, the invention relates to a process for the preparation of the catalyst accoring to the invention. Further, the invention relates to a process for the decomposition of formate in aqueous reaction system, and for the production of hydrogen gas free of CO x , still further, a process for the hydrogenation of hydrogen carbonate in an aqueous reaction system, as well as the production of the respective formate. Further, the invention relates to a process for the decomposition of formate accoring to the invention, and the hydrogenation of the carbonate generated in the same reaction system. The invention relates to a hydrogen storage system based on the process according to the invention, preferably battery or fuel cell, and the use thereof.

Phosphorus substituted metallocene compounds for olefin polymerization

This invention relates to a metallocene compounds represented by formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is an indenyl ligand that is substituted with a PR 2 group in the two position of the indenyl ligand, where each R is, independently a hydrocarbyl, substituted hydrocarbyl, halocarbyl, or substituted halocarbyl substituent, and additionally, E may be substituted with 0, 1, 2, 3, 4, 5 or 6 R n where each R n is, independently, a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent, and optionally, two or more adjacent R n substituents may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand, or A may, independently, be defined as E or as X; each X is, independently, an univalent anionic ligand, or both X are joined and bound to the metal atom to form a metallocycle ring, or both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand.

A catalyst system

A CATALYST SUITABLE FOR CARBONYLATING ETHYLENICALLY UNSATURATED COMPOUNDS COMPRISING A GROUP VIIIB METAL OR COMPOUND THEREOF AND A METALLOCENE.

New optically active organo phosphorus compound useful to prepare phosphine-metal catalysts useful to carry out asymmetrical syntheses in organic chemistry

Optically active organo phosphorus compound (I) in which the phosphorus atom carries chirality and a (hetero)aryl group functionalized in position ortho or 2, is new. Optically active organo phosphorus compound of formula (I) in which the phosphorus atom carries chirality and a (hetero)aryl group functionalized in position ortho or 2, is new. P 1>asymmetric P; m : >=1; n : 0-1; E : 2 electrons, BH 3, HBF 4, TfDH, HClO 4, HPF 6, HBr, HI, HCl, HF, CH 3COOH, CH 3COOH or MsOH; R 3>, R 4>H, 1-4C alkyl or 1-4C alkoxy (optionally substituted by F and/or 1-4C alkyl or 1-4C alkoxy (optionally substituted)); R 3>R 4>5-6C cycloalkane, dioxolane, dioxane or Ar e.g. naphth-1,8-diyl (optionally substituted); z : bond between (CR 3>R 4>) nand Z; Ar 1>4-14C (poly)aromatic ring (bonded to P 1>by a bond (x) and bonded to a group Z(CR 3>R 4>) nby a bond (y), where Z(CR 3>R 4>) nis in ortho or 2 position to P 1>) (optionally includes N, O, S or optionally carry N, O, Si, halo and/or optionally substituted 1-10C alkyl and/or alkoxy or form a cyclic ring of Ar and P as phosphino-Ar e.g. phosphinobenzene, 1-phosphinonaphtalene, 2-phosphinonaphtalene, N(R 5>)-2-methyl-7-phosphinoindole or N-(R 5>)-7-phosphinoindoline and Z(CR 3>R 4>) n-Ar-phosphino is N-(R 5>)-2-phosphinopyrrole or N(R 5>)-2-phosphmoindole); R 5>e.g. a carbon skeleton of formula (II); OR 5>(when m is 1) : e.g. 2,3- dihydro-2,2-dimethyl-7-benzofuranyl ring of formula (III); Z : OR 5>, SR 5>, SO 2R 5>, N(R 6>R 7>), C(O)N(R 6>R 7>), N(R 5>), 1-10C trialkylsilyl, triphenylsilyl, 5-14C (hetero)aryl (optionally substituted by F or 1-10C alkyl); A : C, O, S or TsN, CH, CH 2, Si(R 51>) 2-O-Si(R 51>) m1, benzene or pyridine; R 51>1-10C alkyl; m1 : >=1; A 1>-A 4>CH 2or (R 51>)CH; B 1>-B 4>CH 2, C(O), SO 2, (R 8>R 9>)Si, C(O)N or C(O)O; R 8>, R 9>1-18C alkyl, 5-8C cycloalkyl or 6-10C aryl (all ...

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle compounds and process for preparation thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Olefin oligomerisation process with a catalyst comprising a chromium complex with a phosphacycle-containing ligand

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

催化剂体系

一种适用于羰基化烯属不饱和化合物的催化剂，该催化剂含有第VIIIB族金属或其化合物以及金属茂。

Katalizátor és eljárás hidrogéngáznak formiátból történõ elõállítására és hidrogénkarbonát hidrogénezésére, és az ezeket alkalmazó hidrogéntároló rendszer

New diphosphine compound, intermediates for their preparation, transition metal complex containing the compound as ligand and catalyst for asymmetric hydrogenations containing the complex

Phosphor, Arsenic And Antimony Compounds Based Upon Diaryl-anellated Bicyclo[2.2.n] Parent Substances And Catalysts Containing Same

인, 비소 및 안티몬의 신규 화합물들을 리간드로 사용하여 8 족의 전이 금속 착물을 형성할 수 있으며, 이들은 히드로포르밀화 반응, 히드로시안화 반응, 카르보닐화 반응, 수소화 반응, 올레핀 올리고머화 반응 및 올레핀 중합 반응, 그리고 복분해 반응(metathesis)을 위한 촉매로서 사용될 수 있다. New compounds of phosphorus, arsenic and antimony can be used as ligands to form Group 8 transition metal complexes, which are hydroformylation, hydrocyanation, carbonylation, hydrogenation, olefin oligomerization and olefin polymerization Reactions, and can be used as catalysts for metathesis. 인, 비소 및 안티몬 화합물, 리간드, 8 족의 전이 금속 착물, 히드로포르밀화 반응, 히드로시안화 반응, 카르보닐화 반응. Phosphorus, arsenic and antimony compounds, ligands, transition metal complexes of Group 8, hydroformylation reactions, hydrocyanation reactions, carbonylation reactions.

Olefin oligomerisation process with a catalyst comprising a chromium complex with a phosphacycle-containing ligand

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Chromium complex with a phosphacycle-containing ligand and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle-containing ligand for chromium complex and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle-containing ligand for chromium complex and olefin oligomerisation catalyst therefrom

The present invention relates to a composition comprising a phosphacycle-containing ligating compound represented as: wherein: P is phosphorus; X 1 is phosphorus; each of R 1 and R 2 is independently a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; m is 1; R 1 and R 2 are linked together to form a divalent moiety represented as which together with P forms a cyclic structure (phosphacycle) containing from 3 to 10 ring atoms; each of R 3 and R 4 is independently hydrogen, halogen, a substituted or unsubstituted hydrocarbon derivative, a substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group having from one to 50 non-hydrogen atoms; R 3 and R 4 are optionally linked together to form a divalent moiety represented as wherein the optional character of the linkage is depicted by a dashed connection, which together with X 1 forms a cyclic structure containing from 3 to 10 ring atoms; Y is a divalent linking group [L(R 5 ) q ] p between P and X 1 containing from one to 50 non-hydrogen atoms; [L(R 5 ) q ] p is represented by: wherein each L is independently selected from the group consisting of nitrogen; p is an integer number from 1 to 6; R 5 is independently hydrogen, halogen, substituted or unsubstituted hydrocarbon derivative, substituted or unsubstituted heterohydrocarbon derivative, or a substituted or unsubstituted heteroatom group; q is 0, 1, or 2; provided that the [L] p subunit of the divalent linking group [L(R 5 ) q ] p does not comprise an amidine (N-C=N) group; further provided that in at least one phosphacycle of the phosphacycle-containing ligating compound, both atoms directly bonded to P or X 1 are sp 3 hybridized; still further provided that one or two phosphacycles comprising P, R 1 , and R 2 , or comprising X 1 , R 3 , and R 4 , contain no P-N, ...

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

用于铬络合物的含有磷环的配体和由其得到的烯烃低聚催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

chromium complex with a phosphacyl-containing binder and olefin oligomerization catalyst thereof

a invenção se refere à oligomerização de olefinas, tais como etileno, para olefinas superiores, tais como uma mistura de 1-hexeno e 1-octeno, utilizando um sistema de catalisador que compreende a) uma fonte de cromo b) um ou mais ativadores e c) um composto de ligação contendo fosfaciclo. adicionalmente, a invenção se refere a um composto de ligação contendo fosfaciclo e a um processo para a preparação do referido composto. The invention relates to oligomerization of olefins such as ethylene to higher olefins such as a mixture of 1-hexene and 1-octene using a catalyst system comprising a) a source of chromium b) one or more activators and ) a phosphate cyclic binding compound. In addition, the invention relates to a phosphatocycle-containing binding compound and to a process for preparing said compound.

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

phosphaclic-containing binder for chromium complex and olefin oligomerization catalyst thereof

a invenção se refere a oligomerização de olefinas, tais como etileno, até olefinas superiores, tal como uma mistura de 1-hexeno e 1-octeno, utilizando um sistema de catalisador que compreende a) uma fonte de cromo b) um ou mais ativadores e c) um composto de ligação contendo fosfaciclo. adicionalmente, a invenção se refere a um composto de ligação contendo fosfaciclo e a um processo para a preparação do referido composto. The invention relates to oligomerization of olefins such as ethylene to higher olefins such as a mixture of 1-hexene and 1-octene using a catalyst system comprising a) a source of chromium b) one or more activators and ) a phosphate cyclic binding compound. In addition, the invention relates to a phosphatocycle-containing binding compound and to a process for preparing said compound.

olefin oligomerization process with a catalyst comprising a chromium complex with a phosphate-containing binder

a invenção se refere à oligomerização de olefinas, tais como etileno, até olefinas superiores, tal como uma mistura de 1-hexeno e 1-octeno, utilizando um sistema de catalisador que compreende a) uma fonte de cromo b) um ou mais ativadores e c) um composto de ligação contendo fosfaciclo. adicionalmente, a invenção se refere a um composto de ligação contendo fosfaciclo e a um processo para a preparação do referido composto. The invention relates to oligomerization of olefins such as ethylene to higher olefins such as a mixture of 1-hexene and 1-octene using a catalyst system comprising a) a source of chromium b) one or more activators and ) a phosphate cyclic binding compound. In addition, the invention relates to a phosphatocycle-containing binding compound and to a process for preparing said compound.

Phosphacycle compound and process for production thereof

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

具有含有磷环的配体的铬络合物和由其得到的烯烃低聚反应催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Phosphacycle-containing ligand for chromium complex and olefin oligomerization catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Process for oligomerization

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

用于铬络合物的含有磷环的配体和由其得到的烯烃低聚催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Chromium complex with a phosphacycle-containing ligand and olefin oligomerisation catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Addtionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

具有含有磷环的配体的铬络合物和由其得到的烯烃低聚反应催化剂

本发明涉及使用包含a)铬源、b)一种或多种活化剂以及c)含有磷环的配位化合物的催化剂系统，使如乙烯的烯烃低聚成更高级烯烃，如1‑己烯与1‑辛烯的混合物。另外，本发明涉及一种含有磷环的配位化合物和一种用于制得所述化合物的方法。

Chromium complex and catalyst therefrom

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

A catalyst system

A catalyst system

双配位膦配体

本发明涉及一种双配位膦配体，膦的磷原子由桥基连接，双配位膦配体的桥基由含两个芳基的一种邻位稠化的环状体系所组成，其芳基由两个桥相连接，第一个桥用一个-O-或一个-S-原子所组成，第二个桥是含一个氧、硫、氮、硅或碳原子或这些原子的组合的一个基团，两个磷原子在第一个桥的-O-或-S-原子的邻位与两个芳基相连。本发明还涉及将该双配位膦配体用于一种还含一种过渡金属化合物的催化体系，该体系可用于以下类型的反应：氢甲酰化、氢化、氢氰化、聚合、异构化、羰基化、交联和复分解。

A catalyst system comprising a 1,2-bis-(phosphinoalkyl) ferrocene ligand

A catalyst suitable for carbonylating ethylenically unsaturated compounds comprising a Group VIIIB metal or compound thereof and a metallocene.

Phosphorus substituted metallocene compounds for olefin polymerization

This invention relates to a metallocene compounds represented by formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is an indenyl ligand that is substituted with a PR 2 group in the two position of the indenyl ligand, where each R is, independently a hydrocarbyl, substituted hydrocarbyl, halocarbyl, or substituted halocarbyl substituent, and additionally, E may be substituted with 0, 1, 2, 3, 4, 5 or 6 R n where each R n is, independently, a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent, and optionally, two or more adjacent R n substituents may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand, or A may, independently, be defined as E or as X; each X is, independently, an univalent anionic ligand, or both X are joined and bound to the metal atom to form a metallocycle ring, or both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand.

2,2'-bis (diphenylphosphino) -5,5 ', 6,6', 7,7 ', 8,8'-octahydro-1,1'-binaphthyl and transition metal having this as a ligand Complex

A phosphino binaphthyl compound and transition metal complexes thereof

Catalyst and process for the preparation of hydrogen gas from formate and hydrogenation of hydrogen carbonate, and hydrogen storage system using them

The invention relates to a catalyst according to the formula lrCI(cod)(NHC)] + nP (n = 2, 3 or 4), or [lr(cod)(NHC)(P)] + nP (n = 1, 2 or 3), which is suitable to decompose formates in an aqueous reaction system, and for the production of hydrogen gas or hydrogenation of carbonates, wherein Ir means irydium; CI means chlorine; cod means 1,5-cyclooctadiene; NHC means N-heterocyclic carbene, preferably 1-R-3-methylimidasolium chloride, wherein R means C 1-5 alkyl es P means 1,3,5-triaza-7-phosphaadamantane (pta), monosulphonated triphenilphosphine ( m tppms), trisulphonated triphenylphosphine ( m tppts), or four times sulphonated diphenylphosphynopropane (dpppts). Furthermore, the invention relates to a process for the preparation of the catalyst accoring to the invention. Further, the invention relates to a process for the decomposition of formate in aqueous reaction system, and for the production of hydrogen gas free of CO x , still further, a process for the hydrogenation of hydrogen carbonate in an aqueous reaction system, as well as the production of the respective formate. Further, the invention relates to a process for the decomposition of formate accoring to the invention, and the hydrogenation of the carbonate generated in the same reaction system. The invention relates to a hydrogen storage system based on the process according to the invention, preferably battery or fuel cell, and the use thereof.

Process for the hydrogenation of imines

Asymmetric bidentate coordinating cmpds - for prepn of hydrogenation catalysts giving optically active products

Title cpds are of formula (I) or (II): R1R2X-XR1R2 (I) (where X=P, As or Sb, R1=hydrocarbon having >=1 asymmetric C and opt. heteroatoms, R2=aliphatic, cycloaliphatic or aromatic hydrocarbon residue, opt. substd, and R3=divalent hydrocarbon having >=1 asymmetric C atom and opt. heteroatoms). These cpds form complexes with transition metals, esp. Rh, which are useful as hydrogenation catalysts for olefins or acetylenes to give opt. active prods. The cpds may be prepd by reaction of a cpd of formula R2X(M)-X(M)R2 (where M=alkali metal) with an optically active alkyl or aryl tosylate or chloride.

NEW DIPHOSPHINS, THEIR COMPLEXES WITH TRANSITION METALS AND THEIR USE IN ASYMMETRICAL SYNTHESIS

The invention concerns novel optically pure or racemic diphosphines of formula (I), wherein: R<sb>1</sb> and R<sb>2</sb> represent a C<sb>5</sb>-C<sb>7</sb> cycloalkyl group, an optionally substituted phenyl group or a five-membered heteroaryl group; A represents (CH<sb>2</sb>-CH<sb>2</sb>) or CF<sb>2</sb>. The invention also concerns the use of a compound of formula (1) as ligand for preparing a metal complex, useful as chiral catalyst in asymmetric catalysis, and chiral metal catalysts comprising at least a ligand of formula (I).

Patent FR2190830B1

Patent FR2396735B1

Patent FR2230654B1

Method for producing thioether compound

Disclosed is an efficient and widely-applicable method for commercially producing a thioether compound or a thiol compound which is useful as a pharmaceutical product or a production intermediate of a pharmaceutical product. Specifically disclosed is a method for producing a thioether compound represented by the general formula [I] below or a salt thereof. This method is characterized in that a compound represented by the following general formula [III]: [III] (wherein X represents a bromine atom, a chlorine atom or a trifluoromethylsulfonyloxy group, and ring A represents an aryl group or a heteroaryl ring group) or a salt thereof is reacted with a thiol compound represented by the following general formula [II]: [II] or a salt thereof in the presence of a palladium compound such as Pd2(dba)3, a base such as i-Pr2NEt and a phosphorus compound represented by the following formula [AA].

OPTICALLY ACTIVE CITRONELLAL PREPARATION PROCESS

Procédé de préparation de citronellal optiquement actif caractérisé en ce que l'on hydrogène le néral ou le géranial en présence d'un catalyseur constitué par un complexe soluble dans le milieu réactionnel, formé à partir d'un dérivé du rhodium et d'une phosphine chirale. Ce procédé permet d'accéder au d-citronellal intermédiaire de la synthèse du (-) (1S) menthol. Process for the preparation of optically active citronellal, characterized in that the neral or the geranial is hydrogenated in the presence of a catalyst consisting of a complex soluble in the reaction medium, formed from a rhodium derivative and a phosphine chiral. This process provides access to the d-citronellal intermediate in the synthesis of (-) (1S) menthol.

PROCEDURE TO PREPARE CITRONELLAL ACTIVE OPTICATION

PROCEDURE FOR PREPARING OPTICALLY ACTIVE CITRONELLAL.

Phosphine ligands

Compounds of Formula (I) wherein R, R 1 , R 2 and R 9 are as herein defined, processes for their preparation and transition metal complexes comprising such compounds are disclosed. The complexes may be attached to insoluble supports and are useful as asymetric catalysts. ##STR1##

Ruthenium-phosphine complex and method for producing the same

New chiral diphsophine compound, its production intermediate, transition metal complex containing the same diphopshine compound as ligand, and asymmetric hydrogenating catalyst containing the same complex

(57)【要約】 【課題】 不斉合成反応とくに不斉水素化触媒の配位子 として有用な新規ジホスフィン化合物を提供する。 【解決手段】 一般式（１） 【化１】 （１） （式中、Ｒ１，Ｒ２は、各々独立に、シクロアルキル、 非置換もしくは置換フェニル、または五員複素芳香環を 示す。）で表されるジホスフィン化合物。

Aryl phosphines with fused ring ortho-alkoxy substitution

An aryl phosphine with fused ring ortho-alkoxy substitution that includes an aryl monophosphine and an aryl bisphosphine.

Process for preparing substituted dimethyl(3-arylbutyl)amine compounds by means of homogeneous catalysis

Compounds of the formula (II) can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous catalysts comprising metal salts or complexes containing metals from the group consisting of Rh, Ir and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of R2 and R3 is not an H atom and the diphosphine ligand is chiral.

Process for preparation of aldehydes

In catalytic hydroformylation of an olefin with hydrogen and carbon monoxide, when a platinum-phosphine complex is used as a catalyst and a compound of tin and an element of the group VIB of the Periodic Table is used as a promotor, condensation of the formed aldehyde as a side reaction is controlled and the intended aldehyde can be obtained in a high yield.

Novel ferrocene-based phosphorus chiral phosphines

Process for the preparation of substituted dimethyl- (3-aryl-butyl) -amine compounds by means of homogeneous catalysis

Verbindungen der Formel II DOLLAR F1 können mit Metallsalzen oder Komplexen, enthaltend Metalle aus der Gruppe Rh, Ir und Ru, die bevorzugt Diphosphinliganden enthalten, unter homogener Katalyse zu den entsprechenden Butanderivaten hydriert werden, wobei zusätzlich herausragende optische Ausbeuten erreicht werden, wenn eines von R·2· und R·3· kein H-Atom und der Diphosphinligand chiral ist. Compounds of the formula II DOLLAR F1 can be hydrogenated to the corresponding butane derivatives with metal salts or complexes containing metals from the group consisting of Rh, Ir and Ru, which preferably contain diphosphine ligands, and in addition outstanding optical yields are achieved if one of R · 2 · and R · 3 · is not an H atom and the diphosphine ligand is chiral.