CATALYST FOR ASYMMETRIC HYDROGENATION OF IMINE, SYNTHESIS METHOD AND APPLICATION THEREOF

A chiral hydrogenated H-BINOL bisphosphine compound is provided, with the structure shown as the following formula (I), wherein both Rand Rare halogen, H or C-Caliphatic group; Ris H or C-Caliphatic group; Ris halogen, amino, nitro, H, C-Caliphatic group or C-Caromatic group; and X is phenyl, substituted phenyl, cyclohexyl, substituted cyclohexyl, C-Caromatic group, or C-Cheterocyclic aromatic group containing one or more heteroatoms selected from N, S, O. The present invention further provides a catalyst for an asymmetric catalytic hydrogenation reaction which contains the compound, wherein the catalyst can produce more than % of enantiomers and efficiency with the turnover number of greater than in the asymmetric hydrogenation reaction of imines. 4. A catalyst for an asymmetric catalytic hydrogenation reaction claim 1 , characterized by comprising a coordination compound which is an iridium-containing coordination compound formed by the compound as claimed in as a ligand and an iridium-cyclooctadiene complex based on a molar ratio of 0.5-5:1.5. The catalyst as claimed in claim 4 , characterized in that the iridium-cyclooctadiene complex is any one of [IrCl(COD)] claim 4 , [IrBr(COD)]or [Ir(COD)]BF.6. The catalyst as claimed in claim 4 , characterized by further comprising a halogen-containing additive claim 4 , a molar ratio of which to the iridium--containing coordination compound catalyst is 0.001-10:1.7. The catalyst as claimed in claim 6 , characterized in that the halogen-containing additive is selected from an alkali metal salt of a halogen family element claim 6 , a halogen-containing C1-C60 quaternary ammonium salt claim 6 , or a halogen-containing C1-C60 aromatic hydrocarbon or aliphatic hydrocarbon.8. The catalyst as claimed in claim 7 , characterized in that the halogen is chlorine claim 7 , bromine or iodine.9. The catalyst as claimed in claim 7 , characterized in that the halogen-containing additive is selected from iodobenzene claim 7 , tetrabutyl ...

COMPLEX CATALYSTS BASED ON AMINO-PHOSPHINE LIGANDS FOR HYDROGENATION AND DEHYDROGENATION PROCESSES

The present application discloses novel PWNN and PWNWP metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, enals, enones, enolates, oils and fats, resulting in alcohols, enols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for a variety of chemicals. 2. The compound of claim 1 , wherein when R′ is PR claim 1 , R is H claim 1 , or when Rand R′ do not form part of a heteroaryl Ris H.3. The compound of claim 1 , wherein R′ taken together with Rand the atoms to which they are attached forms a substituted or unsubstituted heteroaryl claim 1 , such as pyridyl claim 1 , furanyl claim 1 , imidazolyl claim 1 , pyrazolyl or oxazolyl.54. The compound of any one of - claims 1 , wherein n is 1 claims 1 , or m is 1 or both n and m are 1.76. The compound of any one of - coordinated to a transition metal.8. The compound of claim 7 , wherein the transition metal is a group 7 (manganese group) metal claim 7 , a group 8 (iron group) metal claim 7 , group 9 (cobalt group) metal claim 7 , or group 10 (nickel group) metal.9. The compound of claim 7 , wherein the transition metal is Ru or Os.11. The metal complex of claim 10 , which comprises the PWNN ligand wherein R′ taken together with Rand the atoms to which they are attached forms a ...

HYDROGENATION AND DEHYDROGENATION CATALYST, AND METHODS OF MAKING AND USING THE SAME

The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals. 2. The complex of claim 1 , wherein in the compound of Formula I each X is H.5. A process for dehydrogenation of a substrate comprising treating the substrate with a catalytic amount of a complex of Formula II or III{'br': None, 'sub': 'a', '[M(LNN′)Z]\u2003\u2003(II)'}{'br': None, 'sup': 'N', 'sub': a', '2, 'μ[M(LNN′)Z]\u2003\u2003(III)'}{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'according to .'}7. The process of claim 6 , wherein the compound of Formula IV comprises more than one hydroxyl moiety that can undergo dehydrogenation;and/or{'sup': 9', '9, 'wherein Rcomprises an amino group that can undergo dehydrogenation or wherein Ris methyl.'}9. The process of claim 5 , wherein the process does not require a hydrogen acceptor; and/orwhich is a homogeneous process.10. A process for producing Hcomprising dehydrogenation of a substrate by treating the substrate with a catalytic amount of a complex of Formula II or III{'br': None, 'sub': 'a', '[M(LNN′)Z]\u2003\u2003(II)'}{'br': None, 'sup': 'N', 'sub ...

Catalyst Systems and Ethylene Oligomerization Method

Disclosed herein is a catalyst system comprising (i) a heterocyclic 2-[(phosphinyl)aminyl]imine transition metal compound complex having Structure I wherein T is oxygen or sulfur, Rand Rare each independently a Cto Corganyl group consisting essentially of inert functional groups, Ris hydrogen or a Cto Corganyl group, L is a Cto Corganylene group consisting essentially of inert functional groups, MXrepresents a transition metal compound where M is a transition metal, X is a monoanion, and p is an integer from 1 to 6, Q is a neutral ligand, and q ranges from 0 to 6, and (ii) an organoaluminum compound. Also disclosed herein is a process comprising contacting (i) ethylene, (ii) a catalyst system comprising (a) a heterocyclic transition metal compound complex having Structure I as described herein and (b) an organoaluminum compound, and (iii) optionally hydrogen to form an oligomer product. 3. The catalyst system of claim 2 , wherein{'sup': 11', '21, 'sub': 1', '10, 'Rand Rare each independently hydrogen or a Cto Calkyl group, and'}{'sup': 12', '13', '14', '22', '23', '24, 'R, R, R, R, R, and Rare hydrogen.'}4. The catalyst system of claim 2 , wherein Ris hydrogen.5. The catalyst system of claim 1 , wherein the transition metal compound comprises a chromium(III) carboxylate claim 1 , a chromium(III) β-diketonate claim 1 , or a chromium(III) halide.6. The catalyst system of claim 1 , wherein the organoaluminum compound comprises an aluminoxane.7. The catalyst system of claim 6 , wherein the aluminoxane comprises methylaluminoxane claim 6 , a modified methylaluminoxane claim 6 , ethylaluminoxane claim 6 , n-propylaluminoxane claim 6 , iso-propylaluminoxane claim 6 , n-butylaluminoxane claim 6 , sec-butylaluminoxane claim 6 , iso-butylaluminoxane claim 6 , t-butyl aluminoxane claim 6 , 1-pentyl-aluminoxane claim 6 , 2-pentylaluminoxane claim 6 , 3-pentylaluminoxane claim 6 , iso-pentylaluminoxane claim 6 , neopentylaluminoxane claim 6 , or mixtures thereof.8. The catalyst ...

HYDROGENATION AND DEHYDROGENATION CATALYST, AND METHODS OF MAKING AND USING THE SAME

The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals. 2. The compound of claim 1 , wherein:{'sup': '3', 'sub': 1', '8', '3', '8', '3', '8', '2', '8', '5', '8, 'Ris H, or C-Clinear alkyl, C-Cbranched alkyl, cyclic alkyl C-C, C-Calkenyl, C-Caryl, each of which may be optionally substituted;'}{'sup': '4', 'sub': 3', '8', '3', '8', '2', '8', '5', '8, 'Ris H a C-Clinear alkyl, C-Ccyclic alkyl, a C-Calkenyl, or a C-Caryl, each of which may be optionally substituted and'}{'sup': '5', 'sub': 1', '8', '3', '8', '3', '8', '3', '8', '5', '8, 'Ris H, a linear C-Calkyl, branched C-Calkyl, cyclic C-Calkyl, C-Calkenyl, or C-Caryl, each of which can be optionally substituted.'}3. The compound of claim 1 , wherein Rand Rare both H.4. The compound of claim 1 , wherein: (i) each Y is C; (ii) k is 2; (iii) each X is H; and/or (iv) L is a phosphine.5. (canceled)6. (canceled)9. The complex of claim 8 , wherein M is a group 7 metal claim 8 , a group 8 metal or a group 9 metal.10. The complex of claim 8 , wherein M is Ru or Os.13. (canceled)16. (canceled)17. The process of claim ...

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Catalyst systems and ethylene oligomerization method

Disclosed herein is a catalyst system comprising (i) a heterocyclic 2-[(phosphinyl)aminyl]imine transition metal compound complex having Structure I wherein T is oxygen or sulfur, R 1 and R 2 are each independently a C 1 to C 20 organyl group consisting essentially of inert functional groups, R 3 is hydrogen or a C 1 to C 20 organyl group, L is a C 1 to C 20 organylene group consisting essentially of inert functional groups, MX p represents a transition metal compound where M is a transition metal, X is a monoanion, and p is an integer from 1 to 6, Q is a neutral ligand, and q ranges from 0 to 6, and (ii) an organoaluminum compound. Also disclosed herein is a process comprising contacting (i) ethylene, (ii) a catalyst system comprising (a) a heterocyclic transition metal compound complex having Structure I as described herein and (b) an organoaluminum compound, and (iii) optionally hydrogen to form an oligomer product.

Method for producing addition products of ethylenic unsaturated compounds by means of catalysts containing bisphospholyl metallocenes

The invention relates to a method for producing addition products to the C=C double bond of ethylenic unsaturated compound in the presence of a catalyst, comprising at least one complex of a metal of the VIII sub-group with at least one bisphospholyl metallocene as ligand. The invention further relates to novel catalysts with phosphametallocenes as ligands.

Novel chiral ligands and their transition metal complexes and their use as catalysts

本発明は、式Ｉの新規なキラル配位子、その製造及び触媒反応における使用に関する。

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.

Hybrid inorganic/organic polymer catalytic membrane materials, containing immobilised molecular catalysts, and their production

FIELD: chemistry. SUBSTANCE: group of inventions relates to catalytic materials for chemical reactors. Said catalytic materials contain hybrid inorganic/polymer carriers and preliminarily obtained molecular catalysts immobilised on them. Hybrid inorganic/polymer carrier consists of hybrid inorganic/polymer compound, in which organic polymers are chemically bound with at least one inorganic compound, selected from the group, consisting of silicic acid compound, tungstic acid compound, molybdic acid compound and stannic acid, and immobilised preliminarily obtained molecular catalyst contains at least one atom or ion of transition metal, selected from groups IB, IIB, IIIB, IVB, VB, VIB, VIIB, VIII of periodic system of elements, which one or several ligand(s) is(are) bound with. EFFECT: claimed catalytic material acts as heterogenic catalyst with selectivity, comparable with selectivity, observed in homogenous phase, with said catalyst being insoluble in reaction solvent and easily removable from reaction mixture. 27 cl, 3 tbl, 7 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 542 364 C2 (51) МПК B01J 31/06 (2006.01) B01J 21/00 (2006.01) B01J 23/00 (2006.01) B01J 37/08 (2006.01) B01J 37/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2011143940/04, 31.03.2010 (24) Дата начала отсчета срока действия патента: 31.03.2010 (43) Дата публикации заявки: 10.05.2013 Бюл. № 13 (45) Опубликовано: 20.02.2015 Бюл. № 5 (73) Патентообладатель(и): НИППОН КОДОШИ КОРПОРЭЙШН (JP) (85) Дата начала рассмотрения заявки PCT на национальной фазе: 01.11.2011 C 2 C 2 Polymeric Membranes: Preparation And Application, APPLIED CATALYSIS A: GENERAL, 2006, vol.307, pp.167-183. CN 1306010 A, 01.08.2001. WO 9828074 A1, 02.07.1998. US 6005148 A, 21.12.1999. US 6228796 B1, 05.05.2001. RU 2255805 C2, 10.07.2005 (86) Заявка PCT: 2 5 4 2 3 6 4 JP 2010/056288 (31.03.2010) R U 2 5 4 2 3 6 4 (56) Список документов, цитированных в отчете о ...

Hydrogenation and dehydrogenation catalyst, and methods of making and using the same

The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals.

Asymmetric catalysis based on chiral phospholanes and hydroxyl phospholanes

Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.

Complex catalysts based on amino-phosphine ligands for hydrogenation and dehydrogenation processes

The present application discloses novel PWNN and PWNWP metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, enals, enones, enolates, oils and fats, resulting in alcohols, enols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for a variety of chemicals.

Catalyst system for synthesizing phenylacetic acid from toluene

本发明公开了一种甲苯合成苯乙酸的催化剂体系，反应路线如下所示：

Novel phosphine compound, transition metal complex containing the same phosphine compound as ligand and asymmetric synthesis catalyst containing the complex

A phosphine compound of formula (1) and a phosphine compound of formula (2) a transition metal complex having the phosphine compound as a ligand and a catalyst for asymmetric hydrogenation including the transition metal complex.

Eta 5-phospholyl complexes and their use in hydroformylation

Synthesis method of chiral 2, 3-disubstituted tetrahydroquinoline derivative

本发明公开了一种手性2,3‑二取代四氢喹啉衍生物的合成方法：以手性苯基骨架膦‑亚磷酰胺配体与金属铱前驱体反应原位制备配合物为催化剂，催化不对称氢化2,3‑二取代喹啉制备手性2,3‑二取代四氢喹啉衍生物。为合成四氢喹啉化合物提供了一条可行途径。与其它合成手性四氢喹啉方法相比，本方法用于氢化的手性苯基骨架膦‑亚磷酰胺配体合成简单、价格低廉、适宜公斤级生产，而且铱/手性二苯基骨架膦‑亚磷酰胺体系催化活性高、对映选择性高，产物的对映体过量值(ee值)最高达96％以上，氢化反应操作简单、条件温和、原子经济性高，具有很好的工业实用性。

ETA 5-PHOSPHOLYL COMPLEXES AND THEIR USE IN HYDROFORMYLATION

Method for producing addition products of ethylenic unsaturated compounds

The invention relates to a method for producing addition products to the C=C double bond of ethylenic unsaturated compound in the presence of a catalyst, comprising at least one complex of a metal of the VIII sub-group with at least one bisphospholyl metallocene as ligand. The invention further relates to novel catalysts with phosphametallocenes as ligands.

Novel phosphine compound, transition metal complex containing said compound as ligand and asymetric synthesis catalyst containing said complex

The invention relates to a phosphine compound of the formula (1): wherein R 1 is a linear or branched alkyl group having 1 to 5 carbon atoms or a cyclohexyl group; R 2 and R 3 represent independently a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; R 4 , R 5 , R 6 and R 7 represent independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms and a di-alkyl amino group, each of the alkyl group having 1 to 5 carbon atoms; X represents a functional group that may form a stable bond with phosphorous atom; and with the proviso that a ring or condensed ring may be formed between the members of at least one pair selected from the group consisting of R 4 and R 5 , R 5 and R 6 , and R 6 and R 7 .

Process for preparing benzidine

本发明涉及一种制备2‑氨基联苯的方法，2‑氨基联苯是制备在农业化学工业中重要的化合物的关键中间体。所述方法包括使邻位取代的苯胺和苯基硼衍生物在碱和钯催化剂的存在下反应，所述钯催化剂包含钯源和式(III)的联苯基膦配体或其盐。

Phosphabenzene compounds and their use in hydroformylation

The invention relates to phosphabenzene compounds of general formula (I), wherein the radicals R<1> to R<13>, independently of each other, are hydrogen, COOM, SO3M, NR3X, NR2, OR, COOR or SR (with M = hydrogen, NH4 or alkali metal, X = anion, R = hydrogen or C1-6-alkyl), or C1-12-alkyl, C6-12-aryl, C7-12-aralkyl, C7-12-alkaryl or C3-6-heteroaromatics. The alkyl, aryl, alkaryl and aralkyl radicals can be substituted with the aforementioned radicals and two or more of the radicals can be linked to form aliphatic or annellated rings, at least one of the radicals R<4> and R<8> and at least one of the radicals R<9> and R<13> being different from hydrogen. The inventive compounds can be used for producing hydroformylation catalysts.

Hydrogenation and dehydrogenation catalysts, and methods of making and using the same

本申请公开了可用作有机化学合成的催化剂的络合物，所述有机化学合成包括不饱和化合物的氢化和脱氢、或底物的脱氢。氢化底物化合物的范围包括酯、内酯、油和脂肪，产生醇、二醇和三醇作为反应产物。本申请的催化剂可以用于在无溶剂条件下催化氢化反应。本催化剂也允许在不加入碱的情况下进行氢化，且它可以用于替代采用主族元素的氢化物的常规还原方法。此外，本申请的催化剂可以在均相和/或无受体条件下催化脱氢反应。这样，本文中提供的催化剂可以用于大幅降低多种化学试剂的制备方法的成本和改善所述制备方法的环境特性。

Tertiary phosphines containing alkylene glycol groups

A compound is disclosed having the formula (I), in which m equals 1 to 1000; x equals 0 to 4; W is a group of formulas -CH2-CH2-, -CH(CH3)CH2- or -CH2CH(CH3)-; R is hydrogen, a straight-chain or branched-chain C1-C5 alkyl radical; or a group of formulas (a) or (b), in which a, b, c, d and e independently represent a number from 0 to 1000, at least one of the numbers represented by a, b, c, d and e being higher than 0; R5, R6, R7, R8 and R9 are the same or different and represent hydrogen, C1-C5 alkyl or a group of formula (c); R1 and R2 are the same or different and represent a straight-chain, a branched-chain or a cyclic C1-C30 alkyl radical or C6-C10 aryl radical which is non-substituted or substituted by one to five C1-C3 alkyl radicals, or R1 and R2 form together with the trivalent P atom a dibenzophospholyl of formula (d) or a 3,4-dimethylphospholyl of formula (e); and L stands for C1-C5 alkyl, C1-C5 alkoxy, NO2, NR3R4, R3 and R4 independently representing hydrogen or C1-C4 alkyl, or for Cl or OH.

Hydrogenation and dehydrogenation catalyst, and methods of making and using the same

The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals.

hydrogenation and dehydrogenation catalyst, and processes for its manufacture and use

Complex catalysts based on amino-phosphine ligands for hydrogenation and dehydrogenation processes

本申请公开用于有机化学合成，包括不饱和化合物的氢化(还原)或基质的脱氢的新PWNN和PWNWP金属催化剂。氢化基质化合物的范围包括酯、内酯、烯醛、烯酮、烯醇化物、油和脂肪，产生作为反应产物的醇、烯醇、二醇和三醇。本申请的所述催化剂可以用于催化无溶剂条件下的氢化反应。本发明催化剂也允许所述氢化在不添加碱的情况下进行，且其可以代替采用主族元素的氢化物的常规还原方法使用。此外，本申请的所述催化剂可以催化均相和/或无受体条件下的脱氢反应。因此，本文提供的所述催化剂可以在关于多种化学品实质上降低制造方法的成本和改善其环境概况中适用。

Tertiary phosphanes containing alkylene glycol groups

A compound is disclosed having the formula (I), in which m equals 1 to 1000; x equals 0 to 4; W is a group of formulas --CH 2 --CH 2 --, --CH(CH 3 )CH 2 -- or --CH 2 CH(CH 3 )--; R is hydrogen, a straight-chain or branched-chain C 1 -C 5 alkyl radical; or a group of formulas (a) or (b), in which a, b, c, d and e independently represent a number from 0 to 1000, at least one of the numbers represented by a, b, c, d and e being higher than 0; R 5 , R 6 , R 7 , R 8 and R 9 are the same or different and represent hydrogen, C 1 -C 5 alkyl or a group of formula (c); R 1 and R 2 are the same or different and represent a straight-chain, a branched-chain or a cyclic C 1 -C 30 alkyl radical or C 6 -C 10 aryl radical which is non-substituted or substituted by one to five C 1 -C 3 alkyl radicals, or R 1 and R 2 form together with the trivalent P atom form a dibenzophospholyl of formula (d) or a 3,4-dimethylphospholyl of formula (e); and L stands for C 1 -C 5 alkyl, C 1 -C 5 alkoxy, NO 2 , NR 3 R 4 , R 3 and R 4 independently representing hydrogen or C 1 -C 4 alkyl, or for Cl or OH. ##STR1##

Process for hydroformylation and catalysts suitable for said process containing phosphorus compounds as ligands

(57)【要約】 錯体を形成することができるλ 3 ，σ 2 −リン化合物を配位子として含有している触媒を使用する、２００℃までの温度と７００バールまでの圧力での、配位子としてリン化合物含有している、元素の周期律表の第VIII亜族の遷移金属の錯体の存在下でのＣＯ／Ｈ 2 を用いたオレフィンのヒドロホルミル化によるアルデヒドの製造方法ならびに新規のホスファベンゼン。

Catalyst for asymmetric hydrogenation of imine, synthesis method and application thereof

A chiral hydrogenation H 8 -BINOL bisphosphine compound is provided, with structural formula (I), wherein R 1 and R 2 are from halogen, H or C 1 -C 10 fatty group; R 3 is H or C 1 -C 10 fatty group; R 4 is from halogen, amino, nitro, H, C 1 -C 10 fatty group or C 1 -C 10 aromatic group; X is from phenyl, substituted phenyl, cyclohexyl, substituted cyclohexyl, C 6 -C 30 aromatic group, C 6 -C 30 heterocyclic aromatic group containing one or more N, S, O. Catalyst for asymmetric hydrogenation is also provided, which contains the said compound. It can obtain the antimer over 90% by the catalyst in asymmetric hydrogenation of imine, and the efficiency of the turn is over number above 100000.

Hydroformylation process and catalysts suitable therefor containing phosphorus compounds as ligands

本发明涉及在含磷化合物作为配体的元素周期表第VIII族过渡金属配合物存在下，在最高200℃的温度和最高700bar的压力下，用CO/H 2 使烯烃加氢甲酰化制备醛的方法中，所用催化剂有能形成配合物的λ 3 ，σ 2 -磷化合物作为配体。本发明还提供了新的磷杂苯。

METHOD FOR PRODUCING PHOSPHABENZENE COMPOUNDS

Catalyst and process for the production of aldehydes by hydroformylation of olefinically unsaturated compounds

Katalysator, enthaltend Rhodium und eine Verbindung der allgemeinen Formel (I), worin m eine Zahl von 1 bis 1000; x eine Zahl von 0 bis 4; W eine Gruppe der Formeln -CH2-CH2-, -CH(CH3)CH2- oder -CH2CH(CH3)-; R Wasserstoff, ein geradkettiger oder verzweigter C1-C5-Alkylrest; oder eine Gruppe der Formeln (a) oder (b), wobei a, b, c, d und e unabhängig voneinander eine Zahl von 0 bis 1000, wobei mindestens eine der Zahlen a, b, c, d und e größer als 0 ist; R?5, R6, R7, R8 und R9¿ gleich oder verschieden sind und Wasserstoff, C¿1?-C5-Alkyl oder eine Gruppe der Formel (c) ist, R?1 und R2¿ gleich oder verschieden sind und einen geradkettigen, verzweigten oder cyclischen C¿1?-C30-Alkylrest oder C6-C10-Arylrest, der unsubstituiert oder durch ein bis fünf C1-C3-Alkylreste substituiert ist, und L C1-C5-Alkyl, C1-C5-Alkoxy, NO2, NR?3R4¿, wobei R?3 und R4¿ unabhängig voneinander Wasserstoff oder C¿1?-C4-Alkyl bedeuten, Cl oder OH bedeuten, für Hydroformylierungsreaktionen.

A kind of preparation method of chirality pyrroline compound

本发明提供了一种手性二氢吡咯类化合物的制备方法，该化合物是制备抗肿瘤药物MK－0731的重要中间体，制备方法以乙烯基碳酸乙烯酯和异氰酸酯为原料，以钯催化的不对称脱羧环加成反应为关键步骤，通过四步化学转换制备手性二氢吡咯类化合物。该制备方法步骤短，反应条件温和，反应产率高，对映选择性优异。

Chiral diols, their manufacture and ligands and catalysts derived therefrom

The present invention relates to a method for the preparation of C 2 -symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R 1 and R 2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C 2 -symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.

Hydrogenation and dehydrogenation catalyst, and methods of making and using the same

The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals. The catalysts are complexes comprising a coordinated ligand that is a compound of Formula I: (see formula I) wherein L, R3-R5, X, Y, k, m, n, z, and the dotted lines are as defined herein.

Asymmetric synthesis catalyzed by transition metal complexes with cyclic chiral phosphine ligands

The present invention relates to rigid chiral ligands useful in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed into catalysts to provide high selectivity of the enantiometric structure of the end-product.

PROCESS FOR THE PREPARATION OF BIPHENILAMINE

Reivindicación 1: Un proceso para preparar un compuesto de la fórmula (4) o una sal del mismo en donde q es un entero seleccionado del grupo que consiste en 0, 1, 2, 3 y 4; p es un entero seleccionado del grupo que consiste en 0, 1, 2, 3, 4 y 5; siempre que al menos uno de p ó q es 1 o más; cada uno de R¹¹ y R¹² está independientemente seleccionado de hidrogeno y un grupo protector de nitrógeno, ó R¹¹ y R¹² forman juntos un grupo cíclico protector de nitrógeno; cada R¹ está independientemente seleccionado del grupo que consiste en halógeno, -OH, alquilo C₁₋₆, ciano, haloalquilo C₁₋₆, alcoxilo C₁₋₆, y haloalcoxilo C₁₋₆; y cada R³ está independientemente seleccionado del grupo que consiste en halógeno, -OH, alquilo C₁₋₆, ciano, haloalquilo C₁₋₆, alcoxilo C₁₋₆, y haloalcoxilo C₁₋₆; comprendiendo el proceso hacer reaccionar una anilina orto-sustituida y un derivado de fenilboro en presencia de una base y un catalizador de paladio, comprendiendo dicho catalizador de paladio una fuente de paladio y un ligando de bifenil fosfina, en donde dicha anilina orto-sustituida es un compuesto de la fórmula (1), o una sal del mismo en donde q, R¹, R¹¹ y R¹² son como se define arriba; y X¹ es un grupo capaz de transmetalación con paladio; en donde dicho derivado de fenilboro es un compuesto de la fórmula (2) en donde p y R³ son como se define arriba; y es un entero seleccionado de 0 ó 1; en donde, cuando y es 1, entonces z es un entero seleccionado de 1, 2 ó 3; cuando y es 0, entonces z es un entero seleccionado de 1, 2, 3 ó 4, y el compuesto de la fórmula (2) forma un borato acompañado de un catión A que tiene una carga a⁺; y cada R² está independientemente seleccionado del grupo que consiste en hidrógeno, halógeno, -OH, -OR⁹, y alquilo C₁₋₁₀, en donde R⁹ es alquilo C₁₋₁₀ ó arilo C₆₋₁₂; o en donde, cuando z es 1, dos grupos R² juntos forman un grupo puente -O-(CH₂)ʳ-O-, en donde r es 2 ó 3, de modo que dichos grupos R², junto con los átomos de oxígeno y el átomo de boro, forman un ...

Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands

This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

Organic / inorganic hybrid catalytic materials, their preparation, use in selective processes and reactors containing them

A low cost, viable and modular method to prepare new, highly selective catalytic materials, especially "catalytic membranes", is described. A method for the engineering and use of various types of reactors based on these catalytic membranes, even in a one-pot procedure, is also disclosed. The catalytic membranes are versatile, in terms of variety of chemical reactions promoted, and can be easily reused with negligible catalysts leaching. They are particularly useful, but not limited to, the asymmetric hydrogenation of substituted .alpha.,.beta. unsaturated acids or esters.

Platinum complexes with ferrocene ligands for the catalysis of alkoxycarbonylation of ethylenically unsaturated compounds

Platin-Komplexe mit Ferrocen-Liganden für die Katalyse der Alkoxycarbonylierung ethylenisch ungesättigter Verbindungen. Platinum complexes with ferrocene ligands for the catalysis of the alkoxycarbonylation of ethylenically unsaturated compounds.

Catalyst for asymmetric hydrogenation of imine, synthesis method and application thereof

A chiral hydrogenation H

Diazaphosphacycles

Diazaphosphacycles comprising compounds having the formula XI and salts of the compound are provided, wherein the variables W, T, R 1 , R 14 , and R 15 are as described herein. Transition metal catalysts incorporating such diazaphosphacycles and methods of use thereof are also disclosed. There are further provided compositions comprising diazaphosphacycles covalently attached to a solid support and methods of use thereof.

Organic / inorganic hybrid catalytic materials, their preparation, use in selective processes and reactors containing them

A low cost, viable and modular method to prepare new, highly selective catalytic materials, especially "catalytic membranes", is described. A method for the engineering and use of various types of reactors based on these catalytic membranes, even in a one-pot procedure, is also disclosed. The catalytic membranes are versatile, in terms of variety of chemical reactions promoted, and can be easily reused with negligible catalysts leaching. They are particularly useful, but not limited to, the asymmetric hydrogenation of substituted .alpha.,.beta. unsaturated acids or esters.

Platinum complexes with ferrocene ligands for catalyzing the alkoxycarbonylation of ethylenically unsaturated compounds

本发明公开了用于催化烯属不饱和化合物的烷氧基羰基化的具有二茂铁配体的铂配合物。

Asymmetric catalysis based on chiral phospholanes and hydroxyl phospholanes

Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.

Phosphine ligands for catalytic reactions

The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.

含氮杂环膦磺酸钯催化剂及其配体和应用

本公开提供了一种含氮杂环膦磺酸钯催化剂及其配体和应用。含氮杂环膦磺酸钯催化剂如式(I)所示，R 1 、R 2 选自取代或未取代的C 1 ～C 6 烃基中的任意一种基团，且R 1 、R 2 中与N原子相连的C原子为sp 3 杂化；R 3 选自取代或未取代的烃基基团或惰性基团。

Phosphabenzolverbindungen und ihre verwendung als liganden für hydroformylierungskatalysatoren

一种手性吡咯烷和四氢呋喃环化合物及其制备方法

本发明公开了一种吡咯烷和四氢呋喃环化合物及其制备方法。具体的公开了高度区域选择性、非对映选择性和对映选择性的钯催化的杂烯丙基前体与各种环状和非环状1,3‑二烯的不对称杂环(3+2)加成反应，得到高度官能化的手性吡咯烷和四氢呋喃环化合物，具有效率高、操作简单、反应条件温和、化学选择性和对映选择性优异等特点。特别是合理设计的PC‑Phos配体在反应效率和选择性方面发挥了关键作用。

一种手性吡咯烷和四氢呋喃环化合物及其制备方法

本发明公开了一种吡咯烷和四氢呋喃环化合物及其制备方法。具体的公开了高度区域选择性、非对映选择性和对映选择性的钯催化的杂烯丙基前体与各种环状和非环状1,3‑二烯的不对称杂环(3+2)加成反应，得到高度官能化的手性吡咯烷和四氢呋喃环化合物，具有效率高、操作简单、反应条件温和、化学选择性和对映选择性优异等特点。特别是合理设计的PC‑Phos配体在反应效率和选择性方面发挥了关键作用。

一类p-手性膦氧化合物及其制备方法和在不对称催化上的应用

本发明属于不对称催化技术领域，公开了一种P‑手性膦氧化合物及其制备方法和在不对称催化上的应用。本发明提供的目标P‑手性膦氧化合物产率最高89%，对映选择性ee值最高99%，非对映选择性dr值大于30：1。对催化得到的P‑手性膦氧化合物进行还原并用硼烷进行稳定，两步连投的产率为91%，ee值为97%得到高构型保持的还原三价膦产物。对P‑手性膦氧化合物的转化进行研究并延展出双键官能团化产物、金属配合物，为后续产物应用奠定基础和参考。

石墨烯吸附多组分手性催化剂及其在不对称氢化中的应用

本发明公开了石墨烯吸附多组分手性催化剂及其在不对称氢化中的应用，属于有机化学中领域。利用原位固定策略，制备了吸附在石墨烯上的杂化材料多组分手性催化剂2a@graphene，将其应用于脱氢氨基酸衍生物氢化时，表现出良好不对称诱导作用，达到了99％以上转化率，最高96％ee。反应结束后，简单过滤即可再循环利用。本发明对于开发基于非共价相互作用不对称反应的其他多相杂化手性催化剂提供了很好的借鉴。

一种喹喔啉不对称氢化方法

本发明涉及一种喹喔啉不对称氢化方法，至少包括以下步骤：S1、取喹喔啉溶于有机溶剂a后，滴加含有无水有机溶剂b的盐酸溶液，得到喹喔啉盐酸盐；S2、在氮气环境中，将[Rh(COD)Cl] 2 和配体L溶解于无水有机溶剂c中，得到溶液d；S3、将喹喔啉盐酸盐加入溶液d中，得到目标产物，步骤S3的反应式和反应条件如下： 式中：R 1 为C 1‑5 的烷基取代基中的任意一种；R 2 为‑H、C 1‑5 的烷基取代基、卤素原子中的任意一种；R 3 为‑H、C 1‑5 的烷基取代基、卤素原子中的任意一种。

Platinum complexes having ferrocene ligands for the catalysis of the alkoxycarbonylation of ethylenically unsaturated compounds

Platinum complexes having ferrocene ligands for the catalysis of the alkoxycarbonylation of ethylenically unsaturated compounds.

单齿膦配体在钯催化吲哚三号位不对称烯丙基化反应中的应用

本发明属于不对称催化合成领域，具体公开了单齿膦配体在钯催化吲哚三号位不对称烯丙基化反应中的应用，采用两类单齿膦配体和钯盐作用，催化吲哚三号位不对称烯丙基化反应。本发明以烯丙基醋酸酯衍生物与吲哚衍生物为原料，钯催化剂与单齿膦配体室温搅拌配位后，再加入适量的溶剂、碱，密封充氩气，在一定温度下搅拌反应一段时间，反应结束后减压蒸去溶剂，产物经硅胶柱层析分离得到目标产物。本发明方法的优点有：反应操作较简单、条件较温和、原料简单易得、底物适用范围广、产率高、使用新型手性单齿膦配体，可实现高对映选择性Tsuji‑Trost反应。

一种钯催化四氟噻蒽盐合成4-甲基苯乙烯的新方法

本发明公开了一种钯催化四氟噻蒽盐合成4‑甲基苯乙烯新方法。在膦配体AntPhos与金属Pd(OAc) 2 作用下，四氟噻蒽盐作为新型偶联试剂参与的Stille反应。本发明使用Pd/AntPhos作为催化剂，高效地合成了4‑甲基苯乙烯。与传统方法相比，该方法反应条件温和，催化剂活性高及产品的产率高，工艺简便，具有很好的的应用推广价值。

Phosphine-urea ligands for transition metal catalyzed cross-coupling reactions

Carbon-carbon bond forming reactions are the cornerstone of organic chemistry. A new class of ligands was developed for transition metal catalyzed cross-coupling reactions. These phosphine-urea ligands incorporate a urea subunit into the backbone of the ligand, which is designed to bind to the organometallic coupling partner and simultaneously facilitate and direct transmetalation of the nucleophile. Synthetic routes were designed and executed to synthesize phosphine-urea ligands. These ligands catalyze a wide variety of cross-coupling reactions including Suzuki, Negishi, and Buchwald-Hartwig cross-couplings. Aryl-aryl, alkyl-aryl, and alkyl-alkyl C—C cross-couplings are performed successfully with these ligands. In addition, specific chiral phosphine-urea ligands catalyze Negishi cross-couplings enantioselectively from a racemic alkylzinc nucleophile.

一种钯催化四氟噻蒽盐合成联苯的新方法

本发明公开了一种钯催化四氟噻蒽盐合成联苯的新方法。在膦配体AntPhos与金属Pd(OAc) 2 作用下，四氟噻蒽盐作为新型偶联试剂参与的Kumada偶联反应。本发明使用Pd/AntPhos作为催化剂，高效地合成联苯化合物。与传统方法相比，该方法反应条件温和，催化剂活性高及产率高，工艺简便，具有很好的应用推广价值。

一种钯催化四氟噻蒽盐合成4-叔丁基联苯的新方法

本发明公开了一种钯催化四氟噻蒽盐合成4‑叔丁基联苯新方法。在膦配体BI‑DIME与金属Pd(OAc) 2 作用下，四氟噻蒽盐作为新型偶联试剂参与的Suzuki偶联反应。本发明使用Pd/BI‑DIME作为催化剂，高效地合成4‑叔丁基联苯化合物。与传统方法相比，该方法反应条件温和，催化剂活性高及产品的产率高，工艺简便，具有很好的的应用推广价值。

一种钯催化四氟噻蒽盐合成1-甲基-4-(苯基乙炔基)苯

本发明公开了一种钯催化四氟噻蒽盐合成1‑甲基‑4‑(苯基乙炔基)苯新方法。在AntPhos膦配体与金属Pd(OAc) 2 作用下，四氟噻蒽盐作为新型偶联试剂参与的Sonogashira偶联反应。本发明使用Pd/AntPhos作为催化剂，高效地合成了1‑甲基‑4‑(苯基乙炔基)苯。与传统方法相比，该方法反应条件温和，反应活性高、产率高，工艺简便，具有很好的的应用推广价值。

一种镍(ii)催化合成手性五元杂环醇衍生物的方法

本发明公开了一种镍(II)催化合成手性五元杂环醇衍生物的方法。所述的五元杂环醇类化合物是具有如下通式的化合物或所述化合物的对映体、消旋体：

一种钯催化四氟噻蒽盐合成联苯的新方法

本发明公开了一种钯催化四氟噻蒽盐合成联苯的新方法。在膦配体AntPhos与Pd(OAc) 2 作用下，四氟噻蒽盐作为新型偶联试剂参与的Hiyama偶联反应。本发明使用Pd/AntPhos作为催化剂，高效地合成了联苯。与传统方法相比，该方法反应条件温和、催化剂活性高及产率高，工艺简便，具有很好的应用推广价值。

一种钯催化四氟噻蒽盐合成4,4’-二甲基联苯新方法

本发明公开了一种钯催化四氟噻蒽盐合成4,4’‑二甲基联苯新方法。在AntPhos膦配体与金属Pd(OAc) 2 作用下，四氟噻蒽盐作为新型偶联试剂参与的Ullmann偶联反应。本发明使用Pd/AntPhos作为催化剂，高效地合成一系列联芳基化合物。与传统方法相比，该方法反应条件温和，反应活性高、产率高，工艺简便，具有很好的的应用推广价值。

一类p-手性膦氧化合物及其制备方法和在不对称催化上的应用

本发明属于不对称催化技术领域，公开了一种P‑手性膦氧化合物及其制备方法和在不对称催化上的应用。本发明提供的目标P‑手性膦氧化合物产率最高89%，对映选择性ee值最高99%，非对映选择性dr值大于30：1。对催化得到的P‑手性膦氧化合物进行还原并用硼烷进行稳定，两步连投的产率为91%，ee值为97%得到高构型保持的还原三价膦产物。对P‑手性膦氧化合物的转化进行研究并延展出双键官能团化产物、金属配合物，为后续产物应用奠定基础和参考。

一类铂基碗膦配合物和其富勒烯阵列及其制备和应用

本发明属于材料化学技术领域，公开了一类铂基碗膦配合物、铂基碗膦配合物‑富勒烯阵列及其制备方法和应用。本发明是在传统Pt(II)基金属受体中引入可特异性结合富勒烯的“碗膦分子”作为抗衡配体，构建一系列铂基金属有机配合物。再利用非共价相互作用通过共组装形成电子供体/受体对(D/A)的超分子结构，构筑一类杂化光电材料。其中，利用碗膦分子与铂金属配位形成的铂基碗膦配合物，可以在几何和电子上与缺电子的富勒烯受体互补，组装形成的有序碳球阵列结构，可成为制备光收集系统的有前途的平台，在光电材料、太阳能转换和催化等领域具有良好的应用前景。

单齿膦配体在钯催化吲哚三号位不对称烯丙基化反应中的应用

本发明属于不对称催化合成领域，具体公开了单齿膦配体在钯催化吲哚三号位不对称烯丙基化反应中的应用，采用两类单齿膦配体和钯盐作用，催化吲哚三号位不对称烯丙基化反应。本发明以烯丙基醋酸酯衍生物与吲哚衍生物为原料，钯催化剂与单齿膦配体室温搅拌配位后，再加入适量的溶剂、碱，密封充氩气，在一定温度下搅拌反应一段时间，反应结束后减压蒸去溶剂，产物经硅胶柱层析分离得到目标产物。本发明方法的优点有：反应操作较简单、条件较温和、原料简单易得、底物适用范围广、产率高、使用新型手性单齿膦配体，可实现高对映选择性Tsuji‑Trost反应。

一种镍(ii)催化合成手性五元杂环醇衍生物的方法

本发明公开了一种镍(II)催化合成手性五元杂环醇衍生物的方法。所述的五元杂环醇类化合物是具有如下通式的化合物或所述化合物的对映体、消旋体：

一种手性吡咯烷和四氢呋喃环化合物及其制备方法

本发明公开了一种吡咯烷和四氢呋喃环化合物及其制备方法。具体的公开了高度区域选择性、非对映选择性和对映选择性的钯催化的杂烯丙基前体与各种环状和非环状1,3‑二烯的不对称杂环(3+2)加成反应，得到高度官能化的手性吡咯烷和四氢呋喃环化合物，具有效率高、操作简单、反应条件温和、化学选择性和对映选择性优异等特点。特别是合理设计的PC‑Phos配体在反应效率和选择性方面发挥了关键作用。

一种喹喔啉不对称氢化方法

本发明涉及一种喹喔啉不对称氢化方法，至少包括以下步骤：S1、取喹喔啉溶于有机溶剂a后，滴加含有无水有机溶剂b的盐酸溶液，得到喹喔啉盐酸盐；S2、在氮气环境中，将[Rh(COD)Cl] 2 和配体L溶解于无水有机溶剂c中，得到溶液d；S3、将喹喔啉盐酸盐加入溶液d中，得到目标产物，步骤S3的反应式和反应条件如下： 式中：R 1 为C 1‑5 的烷基取代基中的任意一种；R 2 为‑H、C 1‑5 的烷基取代基、卤素原子中的任意一种；R 3 为‑H、C 1‑5 的烷基取代基、卤素原子中的任意一种。

一种甲苯合成苯乙酸的催化剂体系

本发明公开了一种甲苯合成苯乙酸的催化剂体系，反应路线如下所示：

制备联苯胺的方法

本发明涉及一种制备2‑氨基联苯的方法，2‑氨基联苯是制备在农业化学工业中重要的化合物的关键中间体。所述方法包括使邻位取代的苯胺和苯基硼衍生物在碱和钯催化剂的存在下反应，所述钯催化剂包含钯源和式(III)的联苯基膦配体或其盐。

含氮杂环膦磺酸钯催化剂及其配体和应用

本公开提供了一种含氮杂环膦磺酸钯催化剂及其配体和应用。含氮杂环膦磺酸钯催化剂如式(I)所示，R 1 、R 2 选自取代或未取代的C 1 ～C 6 烃基中的任意一种基团，且R 1 、R 2 中与N原子相连的C原子为sp 3 杂化；R 3 选自取代或未取代的烃基基团或惰性基团。

一类铂基碗膦配合物和其富勒烯阵列及其制备和应用

本发明属于材料化学技术领域，公开了一类铂基碗膦配合物、铂基碗膦配合物‑富勒烯阵列及其制备方法和应用。本发明是在传统Pt(II)基金属受体中引入可特异性结合富勒烯的“碗膦分子”作为抗衡配体，构建一系列铂基金属有机配合物。再利用非共价相互作用通过共组装形成电子供体/受体对(D/A)的超分子结构，构筑一类杂化光电材料。其中，利用碗膦分子与铂金属配位形成的铂基碗膦配合物，可以在几何和电子上与缺电子的富勒烯受体互补，组装形成的有序碳球阵列结构，可成为制备光收集系统的有前途的平台，在光电材料、太阳能转换和催化等领域具有良好的应用前景。

一类铂基碗膦配合物和其富勒烯阵列及其制备和应用

本发明属于材料化学技术领域，公开了一类铂基碗膦配合物、铂基碗膦配合物‑富勒烯阵列及其制备方法和应用。本发明是在传统Pt(II)基金属受体中引入可特异性结合富勒烯的“碗膦分子”作为抗衡配体，构建一系列铂基金属有机配合物。再利用非共价相互作用通过共组装形成电子供体/受体对(D/A)的超分子结构，构筑一类杂化光电材料。其中，利用碗膦分子与铂金属配位形成的铂基碗膦配合物，可以在几何和电子上与缺电子的富勒烯受体互补，组装形成的有序碳球阵列结构，可成为制备光收集系统的有前途的平台，在光电材料、太阳能转换和催化等领域具有良好的应用前景。

一种铜催化不对称烯丙基烷基化反应方法及手性化合物

本发明提供了一种铜催化不对称烯丙基烷基化反应方法及制备的手性化合物，所述反应方法包括：在‑78℃‑0℃条件下，以铜盐和手性配体作为催化剂，在溶剂中使有机锂试剂与环状底物进行烷基化反应，其中，所述环状底物、所述铜盐和所述手性配体的摩尔比为1:0.05:(0.055‑0.06)。本发明以有机锂试剂作为不对称烯丙基烷基化反应的亲核试剂，不仅能够实现良好的反应收率及对映选择性，且所用催化剂用量较低。

用于催化烯属不饱和化合物的烷氧基羰基化的具有二茂铁配体的铂配合物

本发明公开了用于催化烯属不饱和化合物的烷氧基羰基化的具有二茂铁配体的铂配合物。

一种通过钯催化不对称环加成反应合成八元桥环化合物的方法

本发明提供了一种通过钯催化不对称环加成反应合成八元桥环化合物的方法，包括步骤如下：于有机溶剂中，在钯催化体系催化，添加剂存在下，γ‑亚甲基‑δ‑戊内酯化合物Ⅰ和苯并[C]异噁唑化合物Ⅱ发生[4+4]环加成反应，得到八元桥环化合物Ⅲ；所述钯催化体系由钯催化剂和手性配体组成。本发明的方法可高立体选择性和区域选择性的生成八元桥环化合物，对八元环化合物进行的高效不对称合成；本发明的通过钯催化的[4+4]环加成反应制备八元环化合物的方法，具有操作方便，底物适用范围广泛，反应原料廉价易得等优点。

一种光学活性薄荷醇的制备方法

本发明提供一种光学活性薄荷醇的制备方法，该方法包含以下步骤：1)化合物A(5‑甲基‑4‑己烯酸甲酯)经碱预处理后，在铜盐手性膦催化剂的作用下与乙酰乙酸乙酯环合生成化合物B(异薄荷二烯酮‑4‑甲酸甲酯)；2)化合物B在碱的作用下发生脱羧反应生成化合物C(异薄荷二烯酮)；3)化合物C在催化剂的作用下还原生成化合物D(异薄荷二烯醇)；4)在手性诱导和催化剂的作用下化合物D加氢生成光学活性薄荷醇。本发明的制备方法的优势在于反应路线新颖，原料易得，价格便宜，而且反应条件温和，适于工业化生产。

一种手性2,3-二取代四氢喹啉衍生物的合成方法

本发明公开了一种手性2,3‑二取代四氢喹啉衍生物的合成方法：以手性苯基骨架膦‑亚磷酰胺配体与金属铱前驱体反应原位制备配合物为催化剂，催化不对称氢化2,3‑二取代喹啉制备手性2,3‑二取代四氢喹啉衍生物。为合成四氢喹啉化合物提供了一条可行途径。与其它合成手性四氢喹啉方法相比，本方法用于氢化的手性苯基骨架膦‑亚磷酰胺配体合成简单、价格低廉、适宜公斤级生产，而且铱/手性二苯基骨架膦‑亚磷酰胺体系催化活性高、对映选择性高，产物的对映体过量值(ee值)最高达96％以上，氢化反应操作简单、条件温和、原子经济性高，具有很好的工业实用性。

一种轴手性膦-烯配体及其制备方法与应用

本发明公开了一种轴手性膦‑烯配体及其制备方法和其在催化不对称烯丙基取代反应中的应用。该手性膦‑烯配体的结构如式I所示，主要特征是具有轴手性联芳基骨架。该轴手性膦‑烯配体可由简单易得的芳基碘化物、芳基溴化物和烯烃通过两步反应合成得到，操作简单，结构易于修饰。该手性膦‑烯配体可用于钯催化的不对称烯丙基取代反应，反应条件温和，产率高，对映选择性好。

膦配体及其制备方法和催化合成邻位四取代联芳烃的应用

本发明公开了一种膦配体及其制备方法和催化合成邻位四取代联芳烃的应用。本发明的膦配体的结构如式I所示。本发明的膦配体或其消旋体可作为金属配体，可高收率或者高光学纯度得到多种官能团的邻位四取代联芳基类化合物。

催化剂体系和乙烯低聚方法

本文公开了一种催化剂体系，所述催化剂体系包括(i)具有结构I的杂环2‑[(氧膦基)胺基]亚胺过渡金属化合物络合物，其中T为氧或硫，R 1 和R 2 各自独立地为基本上由惰性官能团组成的C 1 至C 20 有机基，R 3 为氢或C 1 至C 20 有机基，L为基本上由惰性官能团组成的C 1 至C 20 亚有机基，MX p 表示过渡金属化合物，其中M为过渡金属，X为单阴离子，并且p为1到6的整数，Q为中性配体，并且q范围为0到6，以及(ii)有机铝化合物。本文还公开了一种工艺，所述工艺包括使(i)乙烯、(ii)催化剂体系和(iii)任选的氢接触，从而形成低聚物产物，所述催化剂体系包括(a)本文所述的具有结构I的杂环过渡金属化合物络合物以及(b)有机铝化合物。

石墨烯吸附多组分手性催化剂及其在不对称氢化中的应用

本发明公开了石墨烯吸附多组分手性催化剂及其在不对称氢化中的应用，属于有机化学中领域。利用原位固定策略，制备了吸附在石墨烯上的杂化材料多组分手性催化剂2a@graphene，将其应用于脱氢氨基酸衍生物氢化时，表现出良好不对称诱导作用，达到了99％以上转化率，最高96％ee。反应结束后，简单过滤即可再循环利用。本发明对于开发基于非共价相互作用不对称反应的其他多相杂化手性催化剂提供了很好的借鉴。

一种磷杂菲类叔膦衍生物、其合成方法及应用

本公开属于手性三羟基磷合成技术领域，具体涉及一种磷杂菲类叔膦衍生物、其合成方法及应用。手性的三烃基膦化合物的手性中心靠近反应活性中心，因此通常能够表现良好的催化活性，是手性药物、化工中间体的重要合成原料。环状手性叔膦化合物具有良好的稳定型及配位能力，但相关研究较为空白。本公开提供了一种系列碳、磷、轴手性的9‑薄荷基‑9,10‑二氢磷杂菲类叔膦衍生物及合成方法，采用CDOP作为起始产物，向磷原子上引入薄荷基，再进行分子内环化反应得到了一系列具有10‑位含有不同取代基的环状9‑薄荷基二氢磷杂菲化合物，具有良好的催化活性。

具有多个手性中心的多取代四氢-γ-咔啉类衍生物及其立体多样性的制备方法

本发明公开了一种由亚甲胺叶立德和吲哚衍生的烯丙基碳酸酯参与的通过新型的铜/铱协同催化的烯丙基化/异Pictet–Spengler反应合成具有多个手性中心的多取代四氢‑γ‑咔啉类衍生物，其合成方法为：在有机溶剂中，在惰性气体保护下，以吲哚2位衍生的烯丙基碳酸酯和氨基酸衍生的亚胺作为原料，以铜络合物和铱络合物为共催化剂，加入二异丙基乙胺或碳酸铯，在室温温度下反应，经过后处理，再通过柱层析纯化得到目标化合物。经过变更反应所使用的手性配体的搭配方式，可以以高立体选择性地分别合成同一类化合物的多个立体异构体。

氢化和脱氢催化剂、以及制备和使用它们的方法

本申请公开了可用作有机化学合成的催化剂的络合物，所述有机化学合成包括不饱和化合物的氢化和脱氢、或底物的脱氢。氢化底物化合物的范围包括酯、内酯、油和脂肪，产生醇、二醇和三醇作为反应产物。本申请的催化剂可以用于在无溶剂条件下催化氢化反应。本催化剂也允许在不加入碱的情况下进行氢化，且它可以用于替代采用主族元素的氢化物的常规还原方法。此外，本申请的催化剂可以在均相和/或无受体条件下催化脱氢反应。这样，本文中提供的催化剂可以用于大幅降低多种化学试剂的制备方法的成本和改善所述制备方法的环境特性。