Improved means for measuring quantities or doses of granular or powdered materials

... 234,220. Charlton, S. J. W. March 15, 1924. Measures of capacity.-A disc, plate, or disc b of desired size is attached permanently or temporarily to an elongated wire handle a so that it may be dipped into a bottle &c. and separate a predetermined dose or quantity of powder. The disc or the like is attached at its centre at rightangles to the handle.

Centrifuge cup

Centrifuge cup

Improvements in or relating to centrifuging

... 812,309. Centrifugal separators. BECKMAN INSTRUMENTS Inc. Feb. 6, 1957 [March 14, 1956], No. 4165/57. Class 23 [Also in Groups XXXV, XXXVI and XXXVIII] The temperature inside a centrifuge is sensed by a thermistor 51 (Fig. 7) which is included in a D.C. bridge circuit whose output actuates an indicator 111, and may be used to control a heater 116 whereby the temperature is maintained constant, contact with the ends of the rotating thermistor being effected through mercury cups. The centrifuge comprises a rotor 12 (Fig. 2), driven by an electric motor 37 via gearing 38, contained in a cylinder 19 behind a protecting steel ring 17, in an evacuated steel chamber 13. The cylinder 19 is refrigerated by a compressor unit, and heated by a coil surrounding the bottom bearing of the rotor 12. The thermistor 41 (Fig. 4) is located centrally in the bottom of the rotor, embedded in a metal plug 42, the upper end of the thermistor being in thermal and electrical contact with the rotor, the body of the ...

MEHRPROBEN-ROTORANORDNUNG ZUR HERSTELLUNG VON BLUTFRAKTIONEN

PROCEDURE FOR THE SEPARATION FROM A LIQUID MIXTURE VOLUME INTO AT LEAST TWO COMPONENTS

EINRICHTUNG ZUR AUFARBEITUNG BIOLOGISCHER KULTUREN, INSBESONDERE ZUR DARSTELLUNG VON CHROMOSOMEN

A system and method for calibrating a centrifuge

A sample holder for use in a centrifuge, the sample holder being generally planar and comprising: an aperture or recess for releasably retaining a sample storage member including a sample chamber adapted to contain a volume of liquid; a centre point around which the holder will rotate during use; and one or more calibration features, wherein the calibration feature(s) comprise one or more outer edges, which lie on the side of the or each calibration feature which is furthest from the centre point, and the one or more outer edges comprise a series of radially spaced-apart outer edge portions or positions which are spaced at different distances from the centre point as a function of angular position around the centre point.

Apparatus and method for separating a volume of composite liquid into at least two components

CENTRIFUGE

METHOD AND APPARATUS FOR CENTRIFUGAL COMPACTION

A method and apparatus for the centrifugal compaction of particulate material in which the particulate material is admixed with a liquid to form a slurry and is then placed in a chamber and centrifuged about a main axis to cause the material to compact into a discrete body. A particular feature of the invention is to be found in the fact that the chamber in which the slurry is contained during compacting is caused to rotate about an axis inclined to the main axis so that the particulate material is agitated and thereby nests intimately together during the centrifuging operation thereby resulting in workpieces significantly more dense than can be arrived at by simple centrifuging or even by pressing.

CENTRIFUGE SEPARATOR

METHOD FOR PROCESSING A FLUID AND FLUID PROCESSING DEVICE

The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.

Zentrifuge.

Ultracentrifugeuse

Vorrichtung an Ultrazentrifuge mit Mehrzellenrotor zur wahlweisen Untersuchung der einzelnen Zellen

Ultrazentrifugen-Messzelle

Gerät zur Trennung von Flüssigkeiten mit unterschiedlichem spezifischem Gewicht

ZENTRIFUGE.

Zentrifuge

Verfahren und Gerät für die Probenahme eines vorbestimmten Volumens einer Flüssigkeit

DEVICE FOR THE CENTRIFUGATION OF LIQUID.

CENTRIFUGE AS WELL AS ARRANGEMENT WITH A CENTRIFUGE.

МНОГОСЛОЙНЫЙ ПРОДУКТ КРОВИ

Продукт крови (10), способ получения продукта крови, продукт крови, получаемый способом, и контейнерное средство получения продукта крови. Продукт крови содержит компоненты из цельной крови, особенно фибрин, тромбоциты и лейкоциты. Продукт крови (10) содержит первый слой (21), второй слой (22) и третий слой (23). Второй слой (22) смежный с первым слоем (21) и третьим слоем (23). Первый слой (21) определяет первую внешнюю поверхность (24) продукта крови (10), а третий слой (23) определяет вторую внешнюю поверхность (25) продукта крови (10). Первый слой (21) содержит большую часть фибрина, второй слой (22) содержит большую часть тромбоцитов, а третий слой (23) содержит большую часть лейкоцитов.

Centrifugal machine of precision

Centrifugal machine

CENTRIFUGE

SLANGARRANGEMANG AV ENGANGSTYP FOR EN BLODRENINGSAPPARAT

CENTRIFUGAL DEVICE AND METHOD FOR OVA DETECTION

A centrifugal fecal analyzer device is disclosed for the separation of ova from fecal specimens for microscopic examination. More particularly, the centrifugal device includes a rotor housing, a coring assembly, a mixing chamber centrally located within the housing, and a sediment chamber radially outwardly of the mixing chamber. The coring assembly used to collect a fecal sample is introduced int the rotor assembly through a central top opening, and a detachable handle is removed. The rotor assembly is placed in a centrifuge an spun. A coverslip is placed over the rotor assembly opening, and the ova adhere to the coverslip for analysis using standard microscop methods. In another aspect of the present invention, a centrifugal device is provided in which the ova are delivered through centrifugation to a pipette tip for dispensing onto a microscope slide or coverslip.

Centrifuge for separating a sample into at least two components

The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.

Fluid concentrator

A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

Centrifugal rotor with arc-shaped centrifugal carrier or weight body

A centrifugal rotor includes a support disk and a centrifugal carrier. The centrifugal carrier is assembled within the support disk. The centrifugal carrier includes an arc-shaped body, a sample application chamber, a sample metering chamber, a diluent chamber, a diluent metering chamber, a metering control member and a mixing chamber. The sample metering chamber is communicated with the sample application chamber. The sample metering chamber is positioned radially outward from the sample application chamber. The diluent metering chamber is communicated with the diluent chamber. The diluent metering chamber is positioned radially outward from diluent chamber. The metering control member is slidingly connected within or detachably fixed to the sample metering, chamber or the diluent metering chamber. The mixing chamber is communicated with the diluent metering chamber and the sample metering chamber respectively. The mixing chamber is positioned radially outward from both the diluent metering ...

Method for processing a fluid and fluid processing device

The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.

Zentrifuge, Rotor, Probenbehälter, Probenträger und Indikator

Zentrifuge (1), insbesondere Laborzentrifuge, mit einem Rotor (9) und zumindest einem Probenbehälter (11), der an dem Rotor (9) angeordnet ist, dadurch gekennzeichnet, dass die Zentrifuge (1) zumindest einen Indikator (31, 33, 35, 43, 45) zur optischen Signalisierung zumindest einer Probentemperatur aufweist.

Festwinkelrotor

Mit der vorliegenden Erfindung wird ein Festwinkelrotor (10) für Zentrifugen mit Versteifungsrippen (36, 38) an der Unterseite (32) seines Rotorkörpers (12) bereitgestellt, dessen Rotationsenergie im Betrieb auch bei hohen Geschwindigkeiten vergleichsweise gering ist, wodurch die Sicherheit merklich erhöht wird, ohne dass ein verstärkter Panzerkessel in der damit bestückten Zentrifuge erforderlich wäre. Zugleich bleibt die für den Antrieb des Festwinkelrotors (10) erforderliche Antriebsleistung gering. Der Festwinkelrotor (10) hält auch extremen Belastungen über einen längeren Zeitraum stand. Außerdem ist der Festwinkelrotor (10) kostengünstig herstellbar, weil keine zusätzlichen Bauteile erforderlich sind, sondern die Versteifungsrippen (36, 38) bei der Herstellung des Rotorkörpers (12) mit gefertigt werden können. Schließlich lassen sich auch sehr dünne Rotormäntel (38) verwenden, wodurch die Temperierung der Proben verbessert wird, weil der Festwinkelrotor (10) eine sehr gute strukturelle ...

HEATING SYSTEM FOR ROTATING MEMBERS

Fiber-reinforced swing bucket centrifuge rotor and related methods

A system and method for fluid analysis

Adapter for a centrifuge vessel

The invention relates to an adapter (10) for a centrifuge vessel (30), having a one-piece, shell-like main body which bounds a cavity (11) for receiving the centrifuge vessel (30) and has a base region (12) and a side wall region (13) adjoining the latter, the upper edge (15) of said side wall region defining the opening rim of the cavity, wherein at least one expansion joint (14) is provided in the side wall region (13) and makes it possible, by applying a force, to widen the side wall region (13) from a starting position into a widened position such that the length of the opening rim in the widened position is increased compared with the starting position. The adapter (10) is formed from a plastics material such that the side wall region (13) returns automatically into the starting position when the force is discontinued.

SPINNER

... 1,205,363. Centrifugal separators; mixers. SPETSIALNOE KONSTRUKTORSKOE BJURO ANALTITICHESKOGO PRIBOROSTROENIA AN SSSR. 14 May, 1969 [15 May, 1968], No. 24631/69. Headings B1C and B2P. [Also in Divisions F1, F2 and G1] A spinner for rotating a sample 3 in a nuclear-magnetic-resonance detector of a radio frequency spectrometer comprises a turbine having a rotor 10 formed by two truncated cones disposed end to end within a correspondingly shaped stator 11 and driven by jets of compressed air issuing through nozzles 12, the air also forming a fluid cushion to support the rotor 10. The sample 3 is contained within a test tube 4 connected to the rotor 10 by a collet chuck 9. The tube 4 is surrounded by a radio frequency coil 5 enclosed within a Dewar flask 6 having an inlet 7 and outlet 8 for a temperature controlling stream of fluid. A chamber 14 separates the rotor 10 from the Dewar flask 6 to eliminate the effect of the temperature controlling stream on the rotor, the chamber 14 having an ...

Fiber-reinforced swing bucket centrifuge rotor and related methods

CENTRIFUGAL ANALYSERS

... 1423987 Analytical centrifuge MSE PRECISION MFRS Ltd 15 June 1973 [16 March 1972] 12449/72 Heading B2P [Also in Division G1] A centrifugal analyzer comprises two or more rotors 9, 10 having a pulrality of sample anaylsis chambers 6 each associated with material receiving spaces 4, 5 from which materials can be centrifuged into the respective chamber, and a material loading mechanism 11-14 which is adapted to accept quantities of materials from locations 18, 23 of the analyser at which materials can be stored, and which is movable selectively to loading locations associated with respective rotors for discharging the quantities of materials into the receiving spaces 4, 5 of a selected one of the rotors, whereby a loaded rotor can be rotated to centrifuge its contents while another rotor is being loaded. Each rotor comprises a rotor member 1 and a top plate 2 both made of transparent material and contains a plurality of radially extending series 3 of cavities, each series comprising spaces ...

APPARATUS FOR SIMULTANEOUSLY DECANTING LIQUID FROM A NUMBER OF CONTAINERS

... 1319382 Automatic analysis; centrifugal separator; agitating liquids BECTON DICKINSON & CO 21 April 1971 [29 April 1970] 7710/72 Divided out of 1319381 Headings B1C B1X and B2P Apparatus for centrifuging a mixture of liquid sample and reagent in containers 38, and then decanting the supernatant liquid from all the containers simultaneously comprises (Fig. 1) turntable 10 rotatable by means 20, carriers 30 pivotably mounted about the periphery of the turntable and arranged to receive the container 38, and magnetic means 32, (on the containers) 33, 105 (on the turntable), (Fig. 2) operable to tilt each of the carriers to bring the lower ends of the containers radially inwards of their upper ends. With turntable 10 at rest, the carriers 30 are maintained vertical (position in N in Fig. 2) by springs 90, 91. During centrifugation, carriers 30 swing out to position C. For the decant step, coils 105 are energized, and magnetic insert 32 on each carrier is drawn inwards to pole ring 33 (position ...

Disposable centrifuge pot

Apparatus for processing biological material

CENTRIFUGE SEPARATOR

COMPACT REVERSE FLOW CENTRIFUGE SYSTEM

Provided is a chamber configuration for a reverse flow centrifuge, and a reverse flow centrifuge system configured for low fluid volume and small radius rotation. The compact reverse flow centrifuge system has a reusable subsystem and a single use replaceable subsystem. The replaceable subsystem comprises a separation chamber, fluid delivery manifold and rotational mounting connecting the separation chamber to the fluid manifold. The single use replaceable subsystem provides a closed environment for execution of reverse flow centrifugation processes. The separation chamber has a substantially conical fluid enclosure portion connected to a neck portion, and a dip tube extends centrally through the conical fluid enclosure to provide a fluid path to the tip of the conical fluid enclosure.

CENTRIFUGAL SEPARATION APPARATUS AND CENTRIFUGAL SEPARATION METHOD

A centrifugal separation apparatus includes a plurality of centrifugal separators each comprising a rotator which supports a plurality of sample containers containing a sample therein, a base in which the centrifugal separators are arranged in columns and stages and a route is defined therein, the centrifugal separators being movable inside the base, and a movement mechanism that sequentially move the centrifugal separators along the route in the base.

BONE MARROW CONCENTRATOR

Instrumentation is provided for the separation of a multiple component sample, such as BMA containing lysed red blood cells and a lysing agent, into a desired component, for example a cell pellet containing stem cells, and a remaining component. The application discloses a device that includes a separator configured to separate the desired portion from the remaining portion, a collector that is supported by the separator and configured to collect the desired component of the multiple component sample after the desired component has been separated from the remaining component by the separator, and a housing that at least partially encloses and supports the separator and the collector.

For purifying and fine sorting small metallurgical waste powder particles of a device and method thereof

DEVICE OF CENTRIFUGATION OF LIQUIDS CONTAINING OF THE PARTICLES OR CELLS IN SUSPENSION

Apparatus for the separation of immiscible liquids

Process and apparatus for precise taking away of samples of liquids

CENTRIFUGE SEPARATOR

CENTRIFUGALSEPARATOR DER KERLET GENOM VERKAN AV ATTRAKTIONS- OCH/ELLER YTSPENNINGSKRAFTER KVARHALLER VETSKEPROVET EVEN NER KERLET EJ ROTERAR OCH DESS OPPNING ER VEND NEDAT

A CENTRIFUGE FOR SEPARATING A SAMPLE INTO AT LEAST TWO COMPONENTS

The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.

CENTRIFUGE

ROTOR DEVICE HOUSING FOR ANALYTICAL ULTRACENTRIFUGE

A rotor is accommodated and supported in a rotor chamber for high speed rotation therein. The wall of the rotor chamber is formed with an opening larger than the rotor and the opening is air-tightly closed with a cover. When the rotor is to be exchanged, the cover is removed and the rotor is exchanged through the opening.

LIQUID DISPENSING APPARATUS

A liquid dispensing apparatus for use in performing the Coombs anti-globulin test. The Coombs injecting mechanism includes a removable cartridge containing the serum. The cartridge comprises a tubular barrel which is closed at its forward end by a nozzle and at its rear end by a cylindrical piston positioned within the bore of the barrel. The mechanism further includes a plunger for driving the piston into the bore of the barrel to dispense the liquid from the forward nozzle downwardly into a vial upon demand from a Coombs blood test machine associated therewith.

Self-contained disposable tubing set for sterile preparation of cells by culturing, centrifugation, and column chromatography

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

СПОСОБ И УСТРОЙСТВО ДЛЯ ПРЕДВАРИТЕЛЬНОЙ ОБРАБОТКИПРИ ПОМОЩИ ЦЕНТРИФУГИРОВАНИЯ

... 1. Способ предварительной обработки при помощи центрифугирования образцов, содержащихся в пробирках (Т), располагающихся в контейнерах (Р), перед введением этих образцов в устройство для автоматического анализа (АА), причем упомянутое центрифугирование осуществляют в устройстве (СЕ) центрифугирования, содержащем ротор с вертикально расположенной осью вращения, на периферийной части которого установлены с возможностью качания множество фарфоровых лодочек (NA), в каждой из которых располагается контейнер (Р) с пробирками (Т) для образцов, отличающийся тем, что способ содержит следующие этапы: выявляют наличие пробирок (Т) внутри упомянутых контейнеров (Р) во время их транспортировки в устройство (СЕ) центрифугирования, выявляют прогнозируемую несбалансированность этого устройства центрифугирования и при обнаружении такой несбалансированности, связанной с наличием не полностью заполненных пробирками контейнеров или с нечетным количеством этих контейнеров (Р), моделируют загрузки устройства ...

Method and apparatus for fractionating mixtures of substances

Method for fractionating mixtures of substances in an ionic liquid, which, owing to density differences in a previously produced density gradient field, can be separated, for example by centrifuging or sedimentation, the separated substances being pressed out of the separating vessel with a heavy liquid, which is immiscible with the charged ionic gradient liquid, and fractionated via a measuring probe. The charged ionic gradient liquid is temperature-controlled and subsequently separated according to the conductivity and in this way fractionated into individual preselectable density classes, the correlation between the conductivity value and the density being carried out by means of a calibration curve to be determined for the respective gradient medium.

Fixed angle centrifuge rotor

USER-CONFIGURABLE ANALYTIC ROTOR SYSTEM

MECHANISM FOR THE PROCESSING OF BIOLOGICAL CULTURES, IN PARTICULAR FOR THE REPRESENTATION OF CHROMOSOMES

CENTRIFUGE FOR THE SEPARATION OF A SAMPLE IN AT LEAST TWO COMPONENTS

ROTOR FOR SEDIMENTATION FIELD FLOW FRACTIONATION

CENTRIFUGING DEVICE

The specification discloses a device for centrifuging liquids and a means for analysing or processing sets of liquid samples and comprising an aforementioned device. More particularly, it relates to a device for centrifuging liquids containing particles or cells in suspension. The invention provides a liquid-centrifuging device which is free from the need for a vertical axis of rotation. The centrifuging device is characterised in that the vessel for holding the liquid to be centrifuged has a shape and is made of a material such that the liquid therein is kept inside it by the action of electrostatis forces even if the vessel is not rotating and its orifice is facing downwards. As a result, the vessel can be disposed in an invariable position relative to the axis of rotation. This invariable position is the position for centrifuging, i.e. at which the free surface of the liquid in the vessel faces the axis of rotation. The axis of rotation may be in any direction but is preferably horizontal ...

USER-CONFIGURABLE ANALYTICAL ROTOR SYSTEM

An analytical rotor system (120) is configured to perform a plurality of tests selected by a user. The analytical rotor comprises a plurality of rotor blocks (101-104) and a rotor base (100). The rotor blocks (101-104) are each configured to perform at least one of the tests on at least one sample in response to centrifugal force. The rotor blocks (101-104) are physically separate units from one another. The rotor base (100) is a physically separate unit from the rotor blocks (101-104) and is configured to allow the user to manually install the rotor blocks (101-104) on the base. The rotor base (100) is configured to hold the installed rotor blocks (101-104) in place during the centrifugal force and to connect to an analytical device (110) that provides the centrifugal force.

“SEPARATION DEVICE INCLUDING/UNDERSTANDING A CHANNEL OF SEPARATION AND A CONTRE-CANAL”

La présente invention concerne un dispositif de séparation, notamment pour un fractionnement flux-force, de substances en suspension dans un liquide porteur, ledit dispositif de séparation comprenant un canal de séparation et un contre-canal. La présente invention a principalement pour but de la séparation de cellules vivantes, préférence d'origine humaine, en particulier de cellules que l'on retrouve dans les fluides corporels.

DISPOSITIF DE CENTRIFUGATION DE LIQUIDES CONTENANT DES PARTICULES OU CELLULES EN SUSPENSION

Dispositif de centrifugation de liquide. Le liquide à centrifuger est disposé dans un récipient 82 qui est en un matériau tel que l'échantillon liquide soit maintenu en son intérieur par l'action de forces d'attraction électrostatique même lorsque son orifice est, en l'absence de rotation, tourné vers le bas. De cette manière, l'axe de rotation peut être horizontal. Application : centrifugation de liquides contenant des particules ou cellules (telles que des hématies) en suspension afin de collecter ces particules ou cellules.

CENTRIFUGEUSE DE LABORATOIRE

A)CENTRIFUGEUSE COMPORTANT UN ROTOR POUR RECEVOIR DES PORTE-OBJETS 4 OU DES OBJETS ET DES DISPOSITIFS DE REGULATION POUR PILOTER LA VITESSE DE ROTATION DE LA CENTRIFUGEUSE. B)CARACTERISEE EN CE QUE, COAXIALEMENT AU ROTOR DE LA CENTRIFUGEUSE 1, 11, 21, 31, 51 EST DISPOSE, AVEC POSSIBILITE DE COULISSEMENT AXIAL SUR L'ARBRE6, AU MOINS UN DEUXIEME ROTOR2, 12A, 12B, DONT LA VITESSE DE ROTATION PEUT SE REGLER INDEPENDAMMENT DE LA VITESSE DE ROTATION DU ROTOR DE LA CENTRIFUGEUSE. C)CENTRIFUGEUSE APPLICABLE A DES EXPERIENCES DE BIOPHYSIQUE SOUS ACCELERATION VARIABLE.

INTEGRATED VALVE UNIT, AND NUCLEATED CELL EXTRACTING DEVICE USING SAME

The present invention relates to an integrated valve unit capable of extracting nucleated cells from a tissue extract by centrifuging the tissue extract, and to a nucleated cell extracting device using the same. To this end, the integrated valve unit according to the present invention comprises: a hollow main pipe; a plurality of sub-pipes for connecting the main pipe respectively with a raw liquid pack for storing a tissue extract, an enzyme pack for storing decomposition enzymes for decomposing tissue from the tissue extract, an extracting pack for storing nucleated cells separated from the tissue, a washing pack for storing a washing liquid mixed with the tissue extract or the nucleated cells, and a waste liquid pack for storing foreign materials separated from the tissue extract; a fixing block in which the main pipe and the sub-pipes are inserted and supported; and an opening and closing valve for individually opening and closing the sub-pipes supported on the fixing block. Moreover ...

The Centrifugal Tube Filtration Apparatus And The Particle Separation Method

FLUID PROCESSING DEVICE

BLOOD WASHING APPARATUS

Fixed angle centrifuge rotor having torque transfer members

A fixed angle centrifuge rotor includes a rotor body having a circumferential sidewall and a plurality of circumferentially spaced tubular cavities. An annular containment groove is disposed above and circumferentially surrounds the tubular cavities. Each tubular cavity has an open end and a closed end, and is configured to receive a sample container therein. The rotor further includes a pressure plate operatively coupled to the rotor body so that the pressure plate, in combination with the plurality of tubular cavities and the circumferential sidewall of the rotor body, define a hollow chamber within the rotor. The pressure plate includes circumferentially spaced upstanding tabs that are received in respective pockets located between adjacent tubular cavities. The rotor further includes a plurality of elongated torque transfer members supported by the rotor body. Each of the plurality of torque transfer members has a first end located between a respective pair of adjacent tubular cavities ...

Adapter für einen Probenbehälter einer Zentrifuge sowie Adaptergruppe und Zentrifugiersystem

Adapter (20) zum Einsetzen eines Probenbehälters (10) in einen Zentrifugenbecher (40), umfassend einen becherartigen Grundkörper (21), der einen Hohlraum (25) zur Aufnahme des Probenbehälters (30) begrenzt und einen Bodenbereich (24) und einen an diesen anschließenden Seitenwandbereich (22) aufweist, dessen Oberkante den Öffnungsrand (27) des Hohlraums (25) definiert, und eine Ladeöffnung (26), durch die der Probenbehälter (11) in den Hohlraum (25) einsetzbar ist und die durch den Öffnungsrand (27) begrenzt wird, wobei in dem Seitenwandbereich (22) des Grundkörpers (21) mindestens eine Trennfuge (23) vorhanden ist, die sich vom Öffnungsrand (27) in Richtung auf den Bodenbereich (24) hin erstreckt und die es erlaubt, durch Anlegen einer Kraft den Seitenwandbereich (22) von einer Ausgangsposition (P1) in eine aufgeweitete Position (P2) derart aufzuweiten, dass der Öffnungsrand (27) verglichen mit der Ausgangsposition (P1) einen größeren Umfang besitzt. Der Seitenwandbereich (22) weist zwei ...

A closable centrifuge cup

Improvements in or relating to machines for subjecting instruments to predetermined centrifugal forces

... 1,032,309. Bearings. MINISTER OF FRENCH ARMED FORCES. Oct. 29, 1964 [Nov. 21, 1963], No. 44205/64. Heading F2A. [Also in Divisions G1, G3 and H2] A rotor shaft 1 in a machine for subjecting an accelerometer or other instrument to known centrifugal forces (see Division G1) is supported in an hydraulic footstep bearing 4 and has its upper end mounted in an air bearing 5, Fig. 3 (not shown) Hydraulic bearing. The bearing 4 comprises a flanged pintle 21 entering a blind hole 1a in the shaft 1 and resting on a ball 23 on a plate 22 of hard material. Oil from a pressure source 26 enters a central duct 24 through a radial duct 25 and escapes through radial ducts 27, orifices 28, 29 and a bore 20 in the skirt 1b of the shaft 1. Thereby the shaft 1 is supported by the upper face of the pintle 21 through the medium of an oil film and is centred by another oil film around the pintle and within the skirt 1b. The air bearing 5 comprises two annular members 31, 32 receiving the shaft 1 and formed with ...

Fixing device for a centrifuge rotor cover

Improvements in centrifugal separators

... 1,116,896. Centrifugal separators. M. BARAM. 5 Aug., 1966 [14 Aug., 1965], No. 35091/66. Heading B2P. In a centrifuge, particularly for use in laboratories and comprising a lower part 2 and an upper part I divided by a sludge discharge slit 12 that can be opened and closed by a hydraulically-operated shut-off membrane 10 the lower part 2 consists of an outer vessel 3 fastened on to a drive shaft A and an inner detachable vessel 4, the vessels defining between them a space 5 into which fluid, e.g. water, is introduced via a pipe 6 and passages 61' and passes through borings 8 in a flange 9 of the vessel 3 into a space beneath the membrane 10 in order to expand the latter into sealing contact with the part 1 so as to close the slit 12. Openings 11 are provided in the flange 9 to allow some of the fluid to escape constantly. Liquid material to be centrifuged and clear liquid are respectively introduced into, and removed from, the vessel by means of pipes (not shown) extending through an opening ...

SEPARATING EQUIPMENT WITH A SEPARATION CHANNEL AND A GEGENKANAL

MULTI-SAMPLE ROTOR ARRANGEMENT FOR THE PRODUCTION OF BLOOD PARLIAMENTARY GROUPS

PROCEDURE AND DEVICE FOR THE PRETREATMENT OF SAMPLES BY CENTRIFUGATION

MECHANISM FOR THE PROCESSING OF BIOLOGICAL CULTURES, IN PARTICULAR FOR THE REPRESENTATION OF CHROMOSOMES

BLOOD TEST MACHINE

BLOOD TEST MACHINE

BONE MARROW CONCENTRATOR

Instrumentation is provided for the separation of a multiple component sample, such as BMA containing lysed red blood cells and a lysing agent, into a desired component, for example a cell pellet containing stem cells, and a remaining component. The application discloses a device that includes a separator configured to separate the desired portion from the remaining portion, a collector that is supported by the separator and configured to collect the desired component of the multiple component sample after the desired component has been separated from the remaining component by the separator, and a housing that at least partially encloses and supports the separator and the collector.

MULTILAYERED BLOOD PRODUCT

A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.

CENTRIFUGE INDEXING SEAL HEAD ASSEMBLY AND METHOD

Separator centrifuges car-cleaner

Método e dispositivo para pré-tratamento através da centrifugação de amostras

ULTRACENTRIFUGE WITH ROTOR SPEED IDENTIFICATION

Provisions are made for electronically identifying the maximum allowable speed of an ultracentrifuge rotor for the purpose of supplying the identification information to a rotor overspeed control to prevent spinning a rotor beyond its designed top speed. The top surface of the rotor carries a number of annular bands which may be either black or white. The color of the annular band in each band position is detected by means of an electronic circuit including a light source, a photocell detector, and a transistor switch for each band. Each transistor switch conducts when the annular band from which it receives reflected light is black, but does not conduct when the annular band is white. Each conducting switch puts out a steady voltage signal of different amplitude. The voltage output signals of the transistor switches are added to generate an analog control signal identifying the rotor by the color combination of its annular bands. If there are three annular band positions on the rotor, ...

Fixed angle centrifuge rotor having torque transfer members and annular containment groove

A fixed angle centrifuge rotor includes a rotor body having a circumferential sidewall and a plurality of circumferentially spaced tubular cavities. Each tubular cavity has an open end and a closed end, and is configured to receive a sample container therein. The rotor further includes a pressure plate operatively coupled to the rotor body so that the pressure plate, in combination with the plurality of tubular cavities and the circumferential sidewall of the rotor body, define a hollow chamber within the rotor. The rotor further includes a plurality of elongated torque transfer members supported by the rotor body and an annular containment groove.

Method for Optimizing Spin Time In a Centrifuge Apparatus for Biologic Fluid

A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.

Centrifuge and separation vessel therefore

The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.

Swing rotor for centrifugal separator and centrifugal separator

A swing rotor for a centrifugal separator, the swing rotor including: a hub; and a rotor body disposed around the hub, wherein a plurality of pairs of arms are disposed at the rotor body, wherein a holding pin configured to hold a bucket is disposed to the arm, wherein an engagement portion which is configured to be supported by the holding pin is formed to the bucket, and wherein a sliding surface of the holding pin with an engagement portion of the bucket is formed such that a width of a contact area, which is an area that the holding pin contacts with the engagement portion of the bucket, in an axial direction when the bucket does not swing differs from a width of the contact area in the axial direction when the bucket reaches a horizontal position by swinging during a centrifugal separation operation.

Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses

A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic synthesis or parallel extraction of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis or purification (extraction). In a preferred embodiment, an apparatus and method for separating layers of immiscible or partially miscible liquids compatible with microtiter plate type array(s) of reaction vessels is disclosed. Another application of centrifugation based liquid removal was found for washing the plates in biological assays or synthesis on modified substrates.

System and Methods for Making and Processing Emulsions

An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.

System, apparatus, and method for closed tube sampling and open tube sampling for automated clinical analyzers

A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

System for Blood Separation with Side-Tapped Separation Chamber

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.

System and Method for the Continuous Extraction of a Liquid Phase of Microsamples, and Automated Installation for Taking Them, For Carrying Out the Extraction and Taking Measurements

A continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored is provided. The method may include an extraction system having a centrifuge provided with a plurality of microholders, at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. Each filled microholder has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.

Cassette and system component insertable into a centrifuge in cooperation with the cassette

The invention pertains to a cassette ( 2 ) comprising a product conveying path ( 1, 1 a, 1 b ) and a shut-off device ( 19 a, 19 b ) integrated into the cassette for interrupting a product flow. The shut-off device is arranged at a rim of the cassette such that the shut-off device ( 19 a, 19 b ) can be directly operated manually and/or mechanically. The product-conveying path ( 1, 1 a, 1 b ) leads through the shut-off device ( 19 a, 19 b ). The cassette consists of a lower part ( 5 ) and an upper part ( 7 ) which are connectable to each other by connecting means ( 9, 11, 13, 15 ).

Cassette and system component insertable into a centrifuge in cooperation with the cassette

The invention pertains to a cassette ( 2 ) comprising a product conveying path ( 1, 1 a, 1 b ) and a positioning means ( 3 a, 3 b ) engageable with a counter-piece on a centrifuge having a rotor for separating blood components or on a system component ( 4 ) arranged in a centrifuge. The positioning is effected such that a section of the product conveying path ( 1, 1 a, 1 b ) is aligned with a section of the centrifuge or the system component arranged in the centrifuge. Furthermore, a tube connected with bags is accommodated in the product conveying path ( 1, 1 a, 1 b ).

UMBILICUS FOR USE IN AN UMBILICUS-DRIVEN FLUID PROCESSING SYSTEM

An umbilicus is provided for use in an umbilicus-driven fluid processing system. The umbilicus has a pair of anchor portions, at least one fluid-transmitting lumen, and a drive shaft. The fluid-transmitting lumen and drive shaft extend between the anchor portions. The lumen and drive shaft may be comprised of different materials. If multiple lumen are provided, they may either be separate from each other and the drive shaft or defined in a single umbilicus body which also provides a lumen for receiving at least a portion of the drive shaft. 17-. (canceled)8. An umbilicus for use in an umbilicus-driven fluid processing system , comprising:an elongated, single-piece umbilicus body having enlarged ends and defining a plurality of lumen; and 'one of said lumen receives at least a portion of the drive shaft and at least one other of said lumen is adapted for transmitting a fluid between the enlarged ends of the umbilicus body.', 'an elongated, flexible, non-fluid-transmitting drive shaft extending between the enlarged ends of the umbilicus body, wherein'}9. The umbilicus of claim 8 , wherein the drive shaft comprises a single filament.10. The umbilicus of claim 8 , wherein the drive shaft comprises a plurality of filaments.11. (canceled)12. The umbilicus of claim 8 , wherein the fluid-transmitting lumen has a larger cross-sectional area at the enlarged ends of the umbilicus body than therebetween.13. The umbilicus of claim 8 , wherein the lumen receiving the drive shaft is substantially coaxial with a central axis of the umbilicus body.14. The umbilicus of claim 13 , wherein the umbilicus body defines a plurality of fluid-transmitting lumen symmetrically positioned around the central axis of the umbilicus body.1520-. (canceled)21. The umbilicus of claim 8 , wherein the fluid-transmitting lumen has a different cross-sectional shape at the enlarged ends of the umbilicus body and at a position between the enlarged ends.22. The umbilicus of claim 8 , wherein the fluid- ...

Device for insertion into a rotor of a centrifuge, centrifuge and method for the fluidic coupling of cavities

A device for insertion into a rotor of a centrifuge has at least two bodies stacked one above the other in a stacking direction inside a housing. The housing is configured such that it can be inserted into a holder of the rotor of the centrifuge. With a correct reception of the device in the centrifuge, and upon a rotation of the rotor, a spacing of one of the at least two bodies in relation to the axis of rotation of the rotor is smaller than a spacing of another of the at least two bodies in relation to the axis of rotation of the rotor. A first of the at least two bodies has at least one first cavity and a second cavity and a second body of the at least two bodies has at least one first cavity. The two bodies are movably disposed in relation to each other inside the housing in order to fluidically couple, in a first phase, responding to a rotation of the rotor, the first cavity of the first body to the first cavity of the second body and to fluidically couple in a second phase the second cavity of the first body to the first cavity of the second body.

Centrifuge for separating of whole blood into blood components as well as fluidically communicating containers for insertion into the centrifuge, as well as a method for obtaining a highly enriched thrombocyte concentrate out of whole blood

The invention refers to a centrifuge for separating whole blood into its blood components and a method for extracting a highly enriched thrombocyte concentrate out of whole blood. For this purpose, the centrifuge comprises a closed loop and/or open-loop control unit as well as a drive unit coupled to the closed loop and/or open-loop control unit, a rotor ( 12 ) having at least two container receptacles ( 14 a, 14 b; 16 a, 16 ) for removably holding containers ( 18, 20, 22, 24 ) being in fluid communication with each other, at least one sensor arranged between the container receptacles ( 14 a, 14 b; 16 a, 16 b) and coupled with the closed loop and/or open-loop control unit for detecting a separation layer. Herein, a motor/gear unit ( 30 a, 30 b, 32 a, 32 b ) coupled to the closed loop and/or open-loop control unit is associated with each of the container receptacles ( 14 a, 14 b; 16 a, 16 b ). Each of the motor/gear unit units is in operational contact through means ( 34 ) with each of the containers ( 18, 20, 22, 24 ) supported in the respective container receptacle ( 14 a, 14 b; 16 a, 16 b ) such that a transfer and back-transfer of blood components between the containers ( 18, 20, 22, 24 ) is initiated.

Drive system for centrifuge

A drive assembly for a centrifugal processing system is provided for rotating the yoke assembly (36) about a first axis at a first angular ve locity and rotating the chamber assembly (30) coaxially with the yoke assembly at a second angular velocity A drive motor (54) is provided for rotating the yoke assembly at the first angular velocity and simul taneously rotating the chamber assembly at the second angular ve locity by means of a sun gear (66) mounted to the chamber assembly for rotation about the first axis and a planetary gear (64) mounted to the yoke assembly that is operatively connected to the sun gear such as to impart rotation to the sun gear as it orbits thereabout upon rota

Drive system for centrifuge

A drive assembly for a centrifugal processing system is provided for rotating the yoke assembly ( 36 ) about a first axis at a first angular velocity and rotating the chamber assembly ( 30 coaxially with the yoke assembly at a second angular velocity A drive motor ( 54 ) is provided for rotating the yoke assembly at the first angular velocity and simultaneously rotating the chamber assembly at the second angular velocity by means of a stationary first gear ( 64 ), a second gear ( 68 ) mounted to the yoke assembly that operatively engages the first gear, a third gear ( 74 ) rotatably mounted to the yoke assembly so as to synchronously rotate with the second gear, and a fourth gear ( 76 ) fixed to the chamber assembly that operatively engages the third gear so as to rotate the chamber assembly ( 30 ) relative to the yoke assembly ( 36 ) upon rotation of the yoke assembly about the first gear.

Rotor Device, Centrifuge Bowl, and Centrifuge, and the Production Method Thereof

The invention relates to a rotor device of a centrifuge, in particular a laboratory centrifuge, implemented for rotation about an axis of rotation A in a fluid, having an inner region for accommodating a sample to be centrifuged, an outer wall having an outer surface around which fluid flows during rotation of the rotor device, wherein at least one surface section of the outer surface has a microchannel structure, the channels of which extend at a distance d of adjacent channels, where in particular d<2 mm. The invention also relates to a centrifuge bowl for accommodating a rotor device having microchannel structure, and a method for producing the rotor device and the centrifuge bowl. 110202001. Rotor device (; ; ) of a centrifuge () , in particular a laboratory centrifuge , implemented for rotation about an axis of rotation A in a fluid , havingan inner region for accommodating a sample to be centrifuged,{'b': 21', '31', '41, 'an outer wall having an outer surface (; ; ), around which the fluid flows during rotation of the rotor device,'}{'b': 34', '44', '64', '35', '45', '65, 'wherein at least one surface section of the outer surface has a microchannel structure (; ; ), the channels (; ; ) of which extend in particular at a distance d of adjacent channels, in particular where d<2 mm.'}2. Rotor device according to claim 1 , characterized in that the channels are implemented as depressions in the outer wall of the rotor device and/or as rib elements on the outer wall claim 1 , between which the channels are implemented.3. Rotor device according to claim 1 , characterized in that the channels are arranged such that they each extend substantially in the longitudinal direction parallel to the direction of the wall shear stress claim 1 , which results from the friction of the fluid on the outer wall when the fluid flows along the outer surface at a predetermined rotational speed of the rotating rotor device.4. Rotor device according to claim 1 , characterized in that a ...

CONTINUOUS FLOW SEPARATION CHAMBER

A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core. 1. A centrifuge bowl for continuous separation of whole blood comprising:an outer body rotatable about a longitudinal axis of the centrifuge bowl;a top core located within and rotatable with the outer body, the top core being coaxial with the outer body and having a chimney extending through the top core along the longitudinal axis of the centrifuge bowl;a separation region located between the top core and the outer body, rotation of the centrifuge bowl separating the whole blood within the separation region into a first blood component and a second blood component;an inlet port for introducing whole blood into the centrifuge bowl;an inlet tube fluidly connected to and extending distally from the inlet port and through the chimney, the inlet tube configured to introduce the whole blood into an introduction region;a bypass seal between an outer diameter of the inlet tube and an inner diameter of the chimney, the bypass seal isolating the introduction region from the chimney;a first blood component outlet port for drawing a first blood component out of the centrifuge bowl;a first blood component extraction tube extending from the first blood ...

CENTRIFUGAL SEPARATION METHOD

A storage portion forming a storage space includes an inclined inner wall portion that is connected to a base portion so that the diameter of the inclined inner wall portion gradually decreases; a concave portion is formed at a part of the inclined inner wall portion; and the concave portion includes a concave portion side surface that is connected to a concave portion bottom surface The concave portion is formed at a position, where the concave portion crosses an interface S between the specimen centrifuged during rotation and air, in a radial direction with respect to the central axis; and the maximum width of the concave portion in a circumferential direction around the central axis is included in a range of 2 mm to a length of 20% of the whole circumference. 1. A centrifugal separation method , using a centrifugal separation container , which centrifugally separating a first specific gravity component and a second specific gravity component , of which a specific gravity of the second gravity component is higher than a specific gravity of the first specific gravity component , contained in a specimen injected into a storage space by rotating a container about a central axis of the container as a rotation axis , the centrifugal separation method comprising:injecting a specimen into a storage portion that forms the storage space in the centrifugal separation container,wherein the storage portion includes an inclined inner wall portion of which a diameter gradually decreases from an upper end toward a lower end thereof and the lower end is connected to a base portion, anda concave portion formed at a part of the inclined inner wall portion,the concave portion includes a concave portion side surface that is connected to a concave portion bottom surface with a width of the concave portion gradually decreases toward the concave portion bottom surface from the inclined inner wall portion;rotating the centrifugal separation container about the central axis of the ...

FILTRATION DEVICES FOR BIOLOGICAL SAMPLES

Filtration devices and methods for collecting, filtering, and/or processing biological samples are disclosed. An example filtration device may include a funnel member having a first end region and a second end region. A flange may be coupled to the first end region. A filter support portion may be coupled to the second end region. The filter support portion may include a base, a filter membrane coupled to the base, and a securing member for securing the filter membrane to the base. 1. A filtration device , comprising:a funnel member having a first end region and a second end region;a flange coupled to the first end region;a filter support portion coupled to the second end region; andwherein the filter support portion includes a base, a filter membrane coupled to the base, and a securing member for securing the filter membrane to the base.2. The filtration device of claim 1 , wherein the flange is designed to support the funnel member within a centrifuge tube.3. The filtration device of claim 1 , wherein the securing member includes an outer ring designed to be disposed along an outer surface of the base to secure the filter membrane to the base.4. The filtration device of claim 3 , wherein the base includes an outer retaining region for retaining the outer ring.5. The filtration device of claim 1 , wherein the securing member includes an inner ring designed to be disposed along an inner surface of the base to secure the filter membrane to the base.6. The filtration device of claim 5 , wherein the base includes an inner retaining region for retaining the inner ring.7. The filtration device of claim 1 , wherein the filter support portion is designed to be releasably attached to the funnel member.8. The filtration device of claim 1 , wherein the filter membrane includes a plurality of pores having a diameter of 5 microns or less.9. A method for processing a biological sample claim 1 , the method comprising:collecting the biological sample using an aspiration device; ...

ACTIVE BIOLOGICAL SAMPLE PROCESSING AND THERMAL MANAGEMENT DEVICES

Embodiments for a portable and compact centrifugation and thermal management system capable of separating and transporting biological samples while maintaining sample quality for periods of shipment time are described. A compact, automatic centrifuge holding exactly one sample tube is inside an insulating and thermally managed container suitable for standard shipping. A rotor to retain a sample tube is pre-balanced. An electronic controller starts, times and stops centrifugation automatically, responsive to placement of a lid. Thermal management may comprise a phase change material. Embodiments are free of user controls. Embodiments are free of the need for external power or external control. 1. An apparatus for blood sample separation and shipping comprising:a centrifuge comprising: a motor compartment, a rotor compartment and an axis of rotation;a centrifuge motor adapted to spin a rotor assembly around the axis of rotation via a motor shaft;an electronic controller operatively connected to the centrifuge motor;a battery; wherein the battery provides power to the centrifuge motor and to the electronic controller; 'a rotor frame, a fixed counterweight, an attachment hub, and exactly one sample tube retainer;', 'wherein the rotor compartment comprises: a rotor assembly comprisinga safety liner effectively surrounding at least a portion of an interior perimeter of the rotor compartment;an outer container;a thermal insulation layer between the one sample tube retainer and the outer container;a thermally insulating lid comprising a thermal seal; anda thermal management assembly.2. The apparatus of further comprising:a lid sensor operatively connected to the electronic controller.3. The apparatus of wherein:the apparatus is free of manually operated controls and is free of a manually adjustable counterweight.4. The apparatus of wherein:the apparatus is free of manually operated buttons.5. The apparatus of wherein:the apparatus is free of a manual control for spin time ...

APPARATUS AND METHODS FOR SEPARATING BLOOD COMPONENTS

Apparatus and methods for separating blood components are disclosed in which an apparatus for separating blood generally includes a tube defining a channel and configured for receiving a quantity of blood and a float contained within the tube and having a density which is predefined so that the float is maintained at equilibrium between a first layer formed from a first fractional component of the blood and a second layer formed from a second fractional component of the blood. Upon completion of the centrifugation, the first layer may be removed from the tube while the float isolates the second layer from the first layer. 1. An apparatus for separating blood , comprising:a tube defining a channel and configured for receiving a quantity of blood; anda float contained within the tube and having a density which is predefined so that the float is maintained at equilibrium between a first layer formed from a first fractional component of the blood and a second layer formed from a second fractional component of the blood.2. The apparatus of wherein the float defines a shape selected from the group consisting of spherical claim 1 , ellipsoidal claim 1 , and cylindrical shapes.3. The apparatus of wherein the float defines at least one tapered or slanted surface.4. The apparatus of wherein the float defines at least one non-orthogonal surface relative to a normal surface of the float.5. The apparatus of wherein the float has a density of 1.0 to 1.1 gram/ml.6. The apparatus of wherein the float has a density of 1.03 to 1.07 gram/ml.7. The apparatus of wherein the float has a density which is intermediate of the first layer comprised of a RBC layer and the second layer comprised of a PRP layer.8. The apparatus of wherein an outer diameter of the float is between 98 to 101% of the inner surface of the channel.9. The apparatus of wherein the float has a surface configured to retain a layer of red blood cells.10. The apparatus of wherein the float has a surface configured to ...

AUTOMATED SYSTEM FOR PROCESSING PARTICLES

A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest. 1. A method for separating particles from a liquid biological sample and re-suspending the particles in a secondary liquid , the method comprising: a longitudinal axis about which the vessel is rotatable,', 'an upper portion comprising a top opening for receiving the liquid comprising the particles,', 'a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and', 'an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating;, 'a) introducing the liquid biological sample comprising the particles into a rotatable vessel through the top opening of the rotatable vessel such that the liquid is held by the lower portion of the rotatable vessel, wherein the rotatable vessel comprises'}b) rotating the rotatable vessel about its longitudinal axis at a rotational speed, wherein the liquid comprising the particles is moved to the lateral collection chamber by centrifugal force, and wherein the centrifugal force is sufficient to sediment the particles in the ...

Centrifuge rotor comprising an on-board measurement device

A centrifuge rotor for measuring a characteristic of a sample subjected to centrifugation, the centrifuge rotor including: a rotor body; at least one sample holder for holding a sample; at least one on-board measurement device for measuring a characteristic of the sample held in the at least one sample holder during rotation of the rotor.

CENTRIFUGE

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. 127-. (canceled)30. A centrifuge for isolating and concentrating a fraction of a biologic liquid mixture comprising:a. a chamber having a longitudinal axis, a first end, a second end, and a sidewall extending between said first end and said second end, wherein at least a portion of said sidewall is transparent;b. a first port provided in said chamber at a first radial distance from said longitudinal axis, and in fluid communication with a first valve;c. a second port provided in said chamber at a second radial distance from said longitudinal axis, and in fluid communication with a second valve, said second radial distance being less than said first radial distance;d. a motor configured to rotate said chamber about said longitudinal axis and thereby produce a centrifugal field;wherein the sidewall is configured to direct toward the first port a biologic liquid mixture that is present in the chamber and experiencing a centrifugal field.31. The centrifuge of claim 30 , wherein the sidewall extends from the first end to the second end in a first direction that is away from the longitudinal axis.32. The centrifuge of claim 30 , wherein the sidewall extends from the first end to ...

Improvements to Centrifuge Apparatus

Apparatus used to allow separation of one or more components from a liquid supplied to the apparatus and then, following use of the apparatus, the one or more separated components can be used for further purposes. The apparatus includes a rotatable shaft to which is mounted one or more columns which rotate with the shaft and which also rotate about their own axes and through which the liquid passes. The columns are provided with liquid from flying lead assemblies and the invention provides improved connecting means between the columns and flying lead assemblies to allow the same to be modular. An improved cooling system is also disclosed. 1. Centrifuge apparatus including a drive shaft and at least one column provided to be rotated by the shaft around the same , said apparatus further comprising: a flying lead assembly to allow passage of a liquid introduced into the apparatus and allow separation of one or more components from the liquid , wherein connection means are provided for attaching the flying lead assembly to the at least one column to allow the flying lead assembly and/or column to be modular.2. The apparatus according to claim 1 , wherein the flying lead assembly and column modules are interchangeable with a remainder of the apparatus.3. The apparatus according to claim 1 , wherein the connection means form and maintain a pathway for the liquid and the liquid dynamics between the flying lead assembly and the column.4. The apparatus according to claim 1 , wherein the connection means are provided so as to achieve connection with a range of columns of different shapes.5. The apparatus according to claim 1 , wherein the connection means are reusable.6. The apparatus according to claim 3 , wherein the connection means include an insert part which is located in the liquid pathway.7. The apparatus according to claim 6 , wherein the insert part regulates the liquid pressure as it passes through the connection means.8. The apparatus according to claim 7 , ...

SYSTEM AND METHODS FOR MAKING AND PROCESSING EMULSIONS

An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion. 1. A centrifuge device comprising:a rotor to receive a centrifuge tube and including a slinger to dispense a fluid to the centrifuge tube;a lid disposed over the rotor and including an opening;an adapter secured to the lid in the opening, the adapter including a casing having a cavity and defining a port through the lid, the adapter including a carriage disposed in the cavity of the casing and axially moveable within the casing, the adaptor including a motivator to apply force to the carriage in an axial direction away from the lid, the carriage defining a bore to receive a needle or cannula to extend through the carriage, port, and opening.2. The centrifuge device of claim 1 , further comprising a packing disposed in the bore of the carriage to secure the needle or cannula.3. The centrifuge device of claim 1 , wherein the motivator is disposed in the cavity of the casing.4. The centrifuge device of claim 3 , wherein the carriage defines a recess to receive the motivator.5. The centrifuge device of claim 1 , wherein the motivator is a spring.6. The centrifuge device of claim 1 , further comprising a retaining ring to retain the carriage ...

Method and Apparatus for Sample Separation and Collection

A centrifuge device and method for use are presented. The centrifuge device includes a housing, a chamber, a channel, and a cover. The housing includes a first port and a vent opening and is designed to rotate about an axis passing through a center of the housing. The chamber is defined within the housing and is coupled to the first port. A first portion of the chamber has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width. The channel is coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening. The cover provides a wall that seals the chamber.

CENTRIFUGATION CHAMBER WITH GAS PERMEABLE MEMBRANE LAYERS FOR CELL CULTIVATION

The invention is directed to a centrifuge chamber comprising a cylinder having a base plate and a cover plate, a rotational axis with at least one port for input and/or output of liquids, at least one port for input of gases and at least one layer for cell culturing, wherein the layer for cell culturing comprises a gas-permeable membrane on which cells can be cultured and wherein the at least one port for input and/or output of gases is connected to the gas-permeable membrane. 1. A centrifuge chamber having a rotational axis , an inner circumference and an outer wall , comprising:a base plate;a cover plate;at least one liquid port for liquids;at least one gas port for gases; andat least one layer for cell culturing, wherein each layer for cell culturing comprises a gas-permeable membrane on which cells are cultured, and wherein the base plate is coupled to a gas port and to at least one gas permeable membrane, so that the gas port is in gaseous communication with the at least one gas permeable membrane.2. The centrifuge chamber of claim 1 , wherein each layer includes at least one opening coupled to at least one of an adjacent layer and at least one gas port.3. The centrifuge chamber of claim 1 , wherein the gas permeable membrane is disposed on a support structure.4. The centrifuge chamber according to claim 3 , wherein the gas-permeable membrane claim 3 , the support structure and the base plate are provided with a plurality of spacer elements.5. The centrifuge chamber according to claim 3 , wherein the support structure is provided with channels.6. The centrifuge chamber of claim 1 , wherein the gas permeable membrane is disposed on the base plate.7. The centrifuge chamber according to claim 6 , wherein the base plate is covered with the gas-permeable membrane claim 6 , wherein the membrane is coupled to at least one gas port by at least one opening.8. The centrifuge chamber according to claim 3 , wherein the gas-permeable membrane is coupled to at least one of ...

Apparatus, Systems And Methods For Preparing And Shipping Samples

The disclosed apparatus, systems and methods relate to sample preparation and shipping technologies in a single shippable container. The shipping container contains a single use centrifuge. The centrifuge can be temperature controlled and meets all standards and regulations for the shipping and transport of biological specimens. 1. A system for sample preparation and transportation comprising:a. an openable shippable container; andb. a centrifuge frame comprising a rotor, the centrifuge frame being disposed within the shipping container,wherein the centrifuge frame is constructed and arranged to centrifuge and ship a biological sample.2. The system of claim 1 , wherein the centrifuge frame is constructed and arranged so that the rotor is actuated by closing the openable shipping container.3. The system of claim 1 , wherein the rotor contains an opening for a biological sample and an integrated counter-balancing weight.4. The system of claim 1 , comprising electronics claim 1 , and wherein the rotor is constructed and arranged so as to be a single-use rotor.5. The system of claim 1 , wherein the centrifuge frame comprises at least one switch constructed and arranged to control the operation of the rotor.6. The system of claim 5 , further comprising a battery in operational communication with the at least one switch.7. The system of claim 6 , wherein the shipping container comprises a lid claim 6 , the lid being in operational communication with the at least one switch.8. The system of claim 1 , wherein the centrifugation frame comprises at least one battery and a PCB that is operationally coupled to the rotor claim 1 , wherein the PCB is constructed and arranged to be pre-programmed for a variety of sample types.9. The system of claim 8 , wherein the PCB is operationally integrated with communications components that are constructed and arranged to wirelessly communicate with a receiver.10. The system of claim 9 , wherein the receiver is constructed and arranged to ...

CENTRIFUGAL SEPARATOR WITH DISPOSABLE BOWL LINER

A centrifugal separator includes disposable cartridge having a cylindrical bowl, a core tube assembly, and an annular piston disposed around the core tube assembly and inside the inner surface of the bowl. The disposable cartridge may be automatically loaded and withdrawn from the separator. Feed liquid is injected down the core tube assembly into the lower portion of the bowl, raising the annular piston, while the bowl rotates at high speed, separating solids from the feed liquid to accumulate along the inner surface of the bowl, while collecting clarified centrate as it exits the top of the bowl and through the core tube assembly. In a solids discharge mode, the annular piston is urged downward along a vertical axis to force accumulated solids from the bowl. 1. A disposable cartridge for a centrifugal separator comprising a separator housing , a spindle assembly , a main shaft retained within the spindle assembly for rotation therein and a cylindrical separator bowl , the cylindrical separator bowl having an upper end coupled to the main shaft and a lower end with an opening , the cylindrical separator bowl suspended within the separator housing from the main shaft and operative during a separation mode of operation to rotate at a high speed relative to the spindle assembly to separate feed liquid into centrate and solids , the cartridge comprising: a stainless steel cylindrical liner portion conforming to an inner wall of the cylindrical separator bowl and having an opening at the lower end thereof,', 'a shaft liner conforming to an inner wall of the main shaft and in mechanical communication with the cylindrical liner portion at an upper extent thereof, and', 'a pull rod support disposed axially along the interior length of the cylindrical separator bowl and in mechanical communication with the shaft liner at a lower extent thereof and the cylindrical bowl liner portion at a lower extent thereof,, 'a unitary bowl and support structure, comprising'}a pull rod ...

Centrifuge Rotor, Holding Crown And Holding Crown Arrangement Therefor, And Centrifuge

The present invention relates to a centrifuge rotor with a rotor body and a receptacle arranged centrally therein for receiving a drive head of a drive shaft of a centrifuge which can be rotated about an axis of rotation (R), and sample receptacles for accommodating a plurality of sample containers. A holding crown is arranged on a top side (O) of the rotor body facing away from an insertion side (E) of the drive head, said holding crown having an annular base body, which encloses a central opening, and prongs extending upward away from the top side (O), wherein the holding crown is arranged in such a way that the axis of rotation (R) runs through the central opening. The present invention further relates to a holding crown for use with a centrifuge rotor and having an annular base body enclosing a central opening and prongs emanating from the base body and extending upward, wherein the prongs are offset at least in the region of their free ends by a spacing (A) from an inner edge of the base body. The present invention further relates to a holding crown arrangement comprising the holding crown, and a centrifuge comprising the centrifuge rotor, the holding crown or the holding crown arrangement. 1. A centrifuge rotor , comprising:a rotor body including a receptacle arranged centrally therein for receiving a drive head of a drive shaft of a centrifuge that is rotatable about an axis of rotation (R) and sample receptacles for accommodating a plurality of sample containers,wherein a holding crown is arranged on a top side (O) of the rotor body facing away from an insertion side (E) of the drive head, said holding crown having an annular base body which encloses a central opening and prongs extending upward away from the top side (O), andwherein the holding crown is arranged in such a way that the axis of rotation (R) runs through the central opening.2. The centrifuge rotor according to claim 1 , the base body is arranged so that the center of the central opening lies ...

CENTRIFUGAL SEPARATION APPARATUS AND CENTRIFUGAL SEPARATION METHOD

A centrifugal separation apparatus includes a plurality of centrifugal separators each comprising a rotator which supports a plurality of sample containers containing a sample therein, a base in which the centrifugal separators are arranged in columns and stages and a route is defined therein, the centrifugal separators being movable inside the base, and a movement mechanism that sequentially move the centrifugal separators along the route in the base. 1. A centrifugal separation apparatus comprising:a plurality of centrifugal separators each comprising a rotator which supports a plurality of sample containers containing a sample therein;a base in which the centrifugal separators are arranged in columns and stages and a route is defined therein, the centrifugal separators being movable inside the base; anda movement mechanism that sequentially move the centrifugal separators along the route in the base.2. The centrifugal separation apparatus according to claim 1 , further comprising a controller which executes movement processing in which the centrifugal separators are sequentially moved and centrifugal separation processing in which the rotator is rotated for centrifugal separation processing of the sample.3. The centrifugal separation apparatus according to claim 2 , wherein the route includes a descending column claim 2 , an ascending column claim 2 , a take-in position located in an uppermost stage of the descending column claim 2 , and a take-out position located in an uppermost stage of the ascending column claim 2 ,further comprising:a take-in transfer mechanism which transfers the sample containers to be processed to the centrifugal separator located at the take-in position;a take-out transfer mechanism which transfers the sample containers from the centrifugal separators located at the take-out position,wherein the movement mechanism includes an elevating mechanism which sequentially elevates the centrifugal separators in the ascending column, a lowering ...

Paperfuge: An integrated paper-based centrifugation and microfluidics platform for low-cost diagnostics

A microfluidic centrifuge is provided that includes a microfluidic disc having a pair of through holes that include a first through hole and a second through hole, where the pair of through holes are disposed symmetric and proximal to a central axis of the microfluidics disc, where the microfluidics disc includes a sealable input port and a sealable output port, where the sealable input port and the sealable output port are connected by a microfluidics channel, and a pair of tethers disposed through the pair of through holes that are disposed to twist about each other for unwinding where the tether unwinding is disposed to interact with the through holes, where the microfluidics disc rotates about the central axis. 1) A microfluidic centrifuge , comprising a microfluidic disc having a pair of through holes comprising a first through hole and a second through hole , wherein said pair of through holes are disposed symmetric and proximal to a central axis of said microfluidics disc , wherein said microfluidics disc comprises a sealable input port and a sealable output port , wherein said sealable input port and said sealable output port are connected by a microfluidics channel.2) The microfluidics centrifuge of claim 1 , wherein said microfluidics disc comprises a housing material selected from the group consisting of paper claim 1 , polymethyl methacrylate claim 1 , polydimethylsiloxane claim 1 , and plastic.3) The microfluidics centrifuge of further comprises a first tether and a second tether forming a pair of tethers claim 1 , wherein said pair of tethers are disposed through said pair of through holes claim 1 , wherein said pair of tethers are disposed to twist about each said tether for unwinding claim 1 , wherein said tether unwinding is disposed to interact with said through holes claim 1 , wherein said microfluidics disc rotates about said central axis.4) The microfluidics centrifuge of claim 1 , wherein said sealable input port is disposed proximal to said ...

Five-Port Blood Separation Chamber And Methods Of Using The Same

Systems and methods are provided for separating blood into two or more separated blood components. The system includes a blood separation chamber with a single stage having five ports connected thereto. The five ports include a blood inlet port, a red blood cell outlet port, a platelet-rich plasma outlet port, a platelet-poor plasma outlet port, and a buffy coat outlet port. In the single stage, blood may be separated into a variety of components, such as red blood cells and platelet-rich plasma or red blood cells, platelet-poor plasma, and buffy coat. Depending on the components into which the blood is to be separated, flow out of one or more of the outlet ports may be prevented. 1. A blood separation chamber , comprising:a single stage defined by an inner wall including a perimeter and an outer wall including a perimeter, wherein the inner and outer walls are joined along at least a portion of the perimeters of the inner and outer walls;a blood inlet port connected to the single stage;a red blood cell outlet port connected to the single stage;a platelet-rich plasma outlet port connected to the single stage;a platelet-poor plasma outlet port connected to the single stage; anda buffy coat outlet port connected to the single stage.2. The blood separation chamber of claim 1 , wherein a portion of the inner and outer walls adjacent to the blood inlet port is comprised of a flexible material.3. The blood separation chamber of claim 1 , wherein a portion of the inner and outer walls adjacent to the red blood cell outlet port is comprised of a rigid material.4. The blood separation chamber of claim 1 , whereinthe inner and outer walls are joined at first and second lateral edges of the perimeters,the blood inlet and platelet-rich plasma outlet ports are connected to the single stage adjacent to the first lateral edge, andthe red blood cell, platelet-poor plasma, and buffy coat outlet ports are connected to the single stage adjacent to the second lateral edge.5. The blood ...

AUTOMATED CENTRIFUGE WITH SIDE AND TOP ACCESS

A housing for an automated centrifuge with side and top access is disclosed. The housing includes an inner housing for enclosing at least one labware nest of the automated centrifuge, the inner housing having a top and a side body substantially surrounding the at least one labware nest, wherein the inner housing includes an opening through both a portion of the top and a portion of the body, and a door movably connected to the inner housing, and movable relative to the open between an open position, in which the door exposes the opening, and a closed position in which the door blocks the opening. 120-. (canceled)21. A housing for an automated centrifuge , the housing comprising:an inner housing for enclosing at least one labware nest of the automated centrifuge, the inner housing having a top and a side body substantially surrounding the at least one labware nest, wherein the inner housing includes an opening through both a portion of the top and a portion of the body, wherein the opening is configured so that the labware nest is accessible through the top and through the side body anda door movably connected to the inner housing, and movable relative to the opening between an open position, in which the door exposes the opening, and a closed position in which the door blocks the opening. This application claims the benefit a U.S. Provisional Application Ser. No. 61/503,435 filed on Jun. 30, 2011, and entitled “AUTOMATED CENTRIFUGE WITH SIDE AND TOP ACCESS”, which is incorporated by reference herein in its entirety.Embodiments of the invention relate to an automated centrifuge housing with a door designed such that when opened, the door exposes a portion of both the front, i.e. side, and top of an interior of the automated centrifuge.In a traditional manually-loaded centrifuge, a user would manually load labware, such as plates, tubes, racks of tubes, vials, racks of vials, or flasks, into the centrifuge through a door on the top of the centrifuge, or an opening on ...

Sample carrier centrifuge

The invention relates to a sample carrier centrifuge for a sample carrier ( 24 ) that has at least one sample channel ( 26 ) extending along an essentially central sample channel longitudinal axis (P), having a sample carrier receptacle ( 14 ), which can be rotated around a rotation axis (R) and has a holding section ( 38 ) into which the sample carrier ( 24 ) can be inserted in a loading procedure when the sample carrier receptacle ( 14 ) is not rotating, in which section the sample carrier ( 24 ) is held in the loaded state of the sample carrier receptacle ( 14 ), and from which section the sample carrier ( 24 ) can be removed in an unloading procedure, which is characterized in that a platform ( 22 ) of the sample carrier centrifuge ( 10 ), which is embodied for supporting the sample carrier centrifuge ( 10 ) in accordance with its designated use, is oriented parallel to the rotation axis (R).

SEPARATION SYSTEM

This invention is about a separation system () that effectively separates the biological material into its different components with the effect of centrifugal force and performs processes such as separation of stem cells from bone marrow or fatty tissue with ease. 11. A separation system () which separates and evaluates biological material into different components by means of centrifugal force , and also is basically characterized by ,{'b': '2', 'At least one kit () in which the biological material is evaluated, distributed and preserved,'}{'b': 1', '2, 'At least one separation chamber (.) in which the biological material is placed and separated,'}{'b': 1', '1', '2', '1', '2', '2', '1', '2', '1', '2', '2, 'At least one transfer tube (.) that is between the kit () and the chamber (.) and transfers the raw biological material from the kit () to the chamber (.) and the separated biological material from the container (.) to the kit (),'}{'b': 1', '4', '1', '2', '2', '1', '1', '2', '1', '2', '2', '2, 'At least one piston (.) that is in the chamber (.) and transfers the biological material from the initial container (.) into the container (.) by means of vacuum and pressure created in the environment, that also transfers the separated components from the container (.) to the product container (.) by creating pressure in the environment,'}{'b': 1', '13', '1', '2, 'At least one motor (.) on which the chamber (.) pivots in order to separate the biological material by means of centrifugal force,'}{'b': 1', '23', '1', '13, 'At least one shock absorber (.) that absorbs and dissipates the vibration of the motor (.) and ensures its quite operation,'}{'b': 1', '22', '1', '2, 'At least one volume detector (.) that is in the chamber (.) and determines the volume of the biological material,'}{'b': 1', '19', '1', '1', '1', '2', '2', '2, 'At least one product sensor (.) that is on the transfer tube (.) and identifies and differentiates between the biological material that is ...

ISOLATION TUBE

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. A separation container for extracting a portion of a sample for use or testing , the separation container comprising:a body defining an internal chamber, wherein the body defines an opening, and wherein the body is configured to receive the sample within the internal chamber;a seal disposed across the opening, such that the seal is configured to seal the opening of the body; anda plunger movably disposed at least partially inside the internal chamber, wherein the plunger is configured to be actuated to open the seal and express the portion of the sample.2. The separation container of claim 1 , wherein the body defines an axis extending from the opening to a second end of the body claim 1 , wherein a longitudinal member of the plunger is disposed on the axis claim 1 , wherein the internal chamber defines a diameter radial to the axis claim 1 , and wherein the diameter narrows from a collection diameter to a pellet diameter in a direction extending axially from the second end to the opening.3. The separation container of claim 2 , wherein at least a portion of the plunger is configured to sealingly engage the body at a portion of the body corresponding to the pellet diameter.4. The separation container of claim 3 , wherein the at least the portion of the plunger defines a plunger diameter radial to a ...

BLOOD COMPONENT SEPARATOR

A blood component separator () includes a blood storage vessel () that includes a first storage part () and a second storage part (), a slider () movable from the first storage part to the second storage part, and a flow path () for communicating an inside and an outside of the storage vessel. When the slider is in the first storage part, the first storage part and the second storage part are in communication with each other. When the slider is inserted into the second storage part, a liquid-tight seal is formed between the slider and the inner peripheral surface of the second storage part and the communication between the first storage part and the second storage part is blocked by the slider. The slider is movable in the second storage part while maintaining the liquid-tight seal between the slider and the inner peripheral surface of the second storage part. As the slider enters the second storage part, the blood component in the second storage part is pushed out of the storage vessel through the flow path. 1. A blood component separator for use in centrifugal separation of blood , comprising:a blood storage vessel including a first storage part and a second storage part;a slider movable from the first storage part to the second storage part; anda flow path for communicating an inside and an outside of the storage vessel, whereinwhen the slider is in the first storage part, the first storage part and the second storage part are in communication with each other,when the slider is inserted into the second storage part, a liquid-tight seal is formed between the slider and an inner peripheral surface of the second storage part and the communication between the first storage part and the second storage part is blocked by the slider,the slider is movable in the second storage part while maintaining the liquid-tight seal between the slider and the inner peripheral surface of the second storage part, andas the slider enters into the second storage part, a blood component ...

BLOOD COMPONENT COLLECTION CASSETTE AND MANUFACTURING METHOD OF THE SAME

A blood component collection cassette that can trap a substance where blood components coagulate by using a simple and economical configuration, and a manufacturing method of the blood component collection cassette are provided. 1. A blood component collection cassette which includes a cassette main body , where a flow path is formed , and is configured to be mountable to a blood component separation device , whereinthe cassette main body is formed of a soft material, anda filter member for trapping a substance where blood components coagulate is arranged on the flow path in the cassette main body.2. The blood component collection cassette according to claim 1 , whereinthe cassette main body has a filter housing unit that houses the filter member, andthe filter member is fixed to an inner circumferential portion of the filter housing unit.3. The blood component collection cassette according to claim 1 , whereinthe cassette main body has a first sheet and a second sheet which are formed of a soft material, the first sheet and the second sheet are superposed in a thickness direction and bonded to each other, and the flow path is formed between the first sheet and the second sheet.4. The blood component collection cassette according to claim 3 , whereinan engaging portion attachable to and detachable from a distal end portion of a blow nozzle which is used when the cassette main body is blow-molded is provided to the filter member.5. The blood component collection cassette according to claim 1 , whereinan engaging portion attachable to and detachable from a distal end portion of a tool which is used when the cassette main body is formed is provided to the filter member.6. The blood component collection cassette according to claim 4 , whereinthe filter member has a cylindrical filter main body of which one end is provided with an opening portion and of which another end is provided with a bottom portion, andthe engaging portion protrudes from the other end of the filter ...

AUTOMATED SYSTEM FOR PROCESSING PARTICLES

A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest. 1. An automated system for optically analyzing particles contained in a liquid biological sample , the automated system comprising: a longitudinal axis about which the vessel is rotatable,', 'a transparent outer wall,', 'an upper portion comprising a top opening for receiving the liquid biological sample comprising the particles,', 'a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and', 'an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid, the lateral collection chamber comprising on the surface of its inner wall a region of sedimentation for the particles contained in the liquid biological sample, wherein the lateral collection chamber is fluidically connected to the top opening;, 'a rotatable vessel with an annular peripheral chamber contained in a liquid biological sample, the rotatable vessel comprising,'}a rotary actuator for rotating the rotatable vessel about its longitudinal axis at a rotational speed in a controlled manner, wherein the liquid comprising the ...

Spring operated swing out rotor system and method for a centrifuge

A spring operated swing out rotor system for a centrifuge includes a rotor with a rotor top and a rotor bay extending down from the rotor top, the rotor bay having a bay wall and a bay bottom; a carrier tray rotatably attached to a retaining element on the bay wall; and a compression-resistant element between the tray and the bay wall urging the tray to rotate away from the bay wall, so that when the rotor is at rest, the tray is maintained at a positive angle from vertical, and when the centrifuge spins the rotor, centrifugal force positions the tray at a vertical angle. The compression-resistant element may be a spring or soft foam. 1. A device for a centrifuge , comprising:a rotor with a rotor top and a rotor bay extending down from the rotor top, the rotor bay having a bay wall and a bay bottom;a carrier tray rotatably attached to a retaining element on the bay wall; anda compression-resistant element between the tray and the bay wall urging the tray to rotate away from the bay wall, so that when the rotor is at rest, the tray is maintained at a positive angle from vertical, and when the centrifuge spins the rotor, the tray is held at a vertical angle.2. The device of claim 1 , further comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a second carrier tray rotatably attached to a second retaining element on a second bay wall opposite the bay wall of ; and'}a second compress-resistant element urging the second tray away from the second bay wall.3. The device of claim 1 , further comprising:a post at a center of the bay bottom;wherein the tray has a tray wall, a floor at a lower end of the tray wall, and a lip on a side of the floor opposite the tray wall;the lip and floor have a notch opposite the tray wall; andthe post fits into the notch so that the post and the compression-resistant element retain the tray in place when the rotor is at rest.4. The device of claim 1 , further comprising:a post at a center of the bay bottom;wherein the post further ...

CENTRIFUGE WITH EXCHANGEABLE ROTORS

The invention relates to a dual centrifuge () which has the following: a driveshaft (), a rotor (), which is mounted on the driveshaft () and which can be removed axially in a removal direction (E), for a dual centrifuge, having at least one rotational unit (); an opening () in the rotor (), wherein an end region () of the driveshaft () at least engages into said opening; and an additional drive mechanism () for the rotational unit or the rotational units (). The dual centrifuge additionally has a design for operating various additional types of rotors; however, only one rotor () can be arranged on the driveshaft () at all times. The various rotor types () are also adapted to the additional drive mechanism () for the rotational units () such that the function is not adversely affected. The invention is characterized by a design for operating at least one angular head rotor () and a swing-out rotor (). For this purpose, the driveshaft () and the various rotor types () are adapted to each other. The bearing (), the driveshaft (), and the various rotor types () are adapted to one another such that each non-dual rotor () has a geometry that is measured such that when the rotor () is mounted, a drive means () of the additional drive mechanism () for the rotational units () is arranged so as to not contact the mounted rotor (). 1. Dual centrifuge , comprisinga) driveshaft,b) a dual centrifuge rotor which is mounted on the driveshaft and which can be removed axially in a removal direction, having at least one rotational unit,c) an opening in the rotor which is at least engaged by an end portion of the driveshaft, andd) an additional drive mechanism for the one or plural rotational unit,{'b': '16', 'e) a design for operating various additional types of rotors, in which only one rotor can be arranged on the driveshaft () at a time, and in which the various rotor types are also adapted to the additional drive mechanism for the rotational units such that the function is not ...

Separator and method for separating blood plasma from blood cells

The invention relates to a separator for separating blood plasma and blood cells in a blood collection tube. The separator comprises a float with a first density and at least one passage opening. In addition to the float, the separator comprises a ballast with a second density that is greater than the first density. The total density of the separator, that is, the float and the ballast together, lies between the density of the plasma and the density of the cells in the blood. The float forms a valve together with the ballast. The float and the ballast are arranged so as to be movable relative to each other. In accordance with the invention, the ballast has at least one valve element for opening or closing a passage opening in the float. 1. A separator for separating blood plasma and blood cells in a blood collection tube , comprising:a float having a first density and a passage opening; anda ballast having a second density that is greater than the first density;wherein a total density of the float and the ballast is between a density of the plasma and a density of the cells in the blood;wherein the float and the ballast are movable relative to each other and together form a valve; andwherein the ballast includes a valve member for opening or closing the passage opening in the float.2. The separator according to claim 1 ,wherein the valve member has the form of a pin, which can be inserted into the passage opening in the float.3. The separator according to claim 1 ,wherein the valve member a contact surface on the ballast for covering the passage opening in the float in a sealing manner.4. The separator according to claim 1 ,further comprising a reset element which provides a resilient connection between the float and the ballast,wherein a force is required to open the valve and overcome a restoring force defined by the reset element.5. The separator according to claim 4 ,wherein the reset element is made from the same material as the float.6. The separator according ...

SYSTEM, METHOD AND CONTROLLER FOR RECOVERY OF CONCENTRATED PARTICLES SUSPENDED IN FLUID

Embodiments provide a fluid recovery system and method for use with concentrator systems for concentrating particles suspended in a fluid and where this suspension is recovered from a fluid stream drawn from the concentrator system. A controller is configured to control valve actuation to direct concentrate being drawn from the concentrator chamber through a recovery tube to a recovery reservoir based on fluid volume movement. The system can use a density sensor to detect density transitions in fluid in the fluid recovery tube to identify leading and trailing edges of a portion of concentrated particles in fluid suspension passing through the recovery tube and actuate recovery valves based on objectives for maximising particle recovery with minimal dilution. 149-. (canceled)50. A fluid recovery system configured to operatively engage with a concentrator apparatus comprising a concentrating chamber having a first fluid path and a second fluid path connected in line with a pumping mechanism , whereby to recover concentrated fluid from the concentrating chamber fluid enters the concentrating chamber via the first fluid path as fluid exits the concentrating chamber via the second fluid path to a fluid recovery tube , and a recovery valve assembly and valve actuator configured to switch flow of fluid from the fluid recovery tube one of two or more output fluid tubes , at least one fluid output tube providing a fluid capture path and at least one fluid output tube providing a non-capture path; a density sensor configured to detect density of fluid in the recovery tube preceding the recovery valve assembly when operatively engaged with the concentrator apparatus; and', monitor operation of the fluid pumping mechanism to determine dynamic fluid volume movement of fluid in the fluid recovery tube,', a first density transition in fluid in the fluid recovery tube from a first density to second density, the second density being higher than the first density, the density ...

Centrifugation System With Red Blood Cell Barrier

Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port. 114-. (canceled)15. A method of centrifugally separating blood components from blood , comprising:flowing blood into a first stage of a multiple-stage separation chamber, the first stage having a plasma outlet port and a red cell outlet port;rotating the separation chamber about a rotational axis so as to separate the blood into a separated blood component substantially comprising plasma and a blood component substantially comprising red blood cells;flowing the separated blood components along a path toward the plasma outlet port, wherein the path toward the plasma outlet port includes a first projection which is oriented to impede the separated blood component substantially comprising red blood cells from flowing into the plasma outlet port; and the path toward the red cell outlet port includes a second projection which is oriented to impede the separated blood component substantially comprising plasma from flowing into the red cell outlet port, and', 'one end of the first projection is substantially aligned with one end of the second projection along a radius passing ...

Continuous Flow Centrifuge For Fluid Separation Or Water Desalination And Purification

In an embodiment, a continuous flow centrifuge for water desalination comprises a double walled enclosure casing having a water egress and ingress. The centrifuge rotates around a central axis, which a rotor extends through wherein one or more main ball bearings and one or more thrust roller bearings aid in the rotation. Extending from the rotor is a plurality of radial flow chambers terminating in one or more circumferential drain openings allowing for the selective expulsion of fluid. Pluralities of channel divider discs extend from the rotor and are between the radial flow chambers. A fluid outlet is connected to an egress of the centrifuge. A pump impeller is positioned at the egress wherein water is pulled through the ingress. 1. A continuous flow centrifuge comprising:a. a double-walled enclosure casing having a water ingress, a water egress and central axis, and defining a plurality of radial flow chambers;b. one or more circumferential drain apertures positioned at the outer circumference of the radial flow chambers;c. a rotor extending through the central axis of the centrifuge connected to the centrifuge;d. a plurality of channel divider discs extending outwardly from the rotor;e. a fluid outlet connected to an egress of the centrifuge.2. The continuous flow centrifuge of claim 1 , wherein the channel divider discs are each positioned within a radial flow chamber claim 1 , and are adapted to rotate around the axis within the radial flow chambers.3. The continuous flow centrifuge of further comprising one or more O-ring seals at a plurality of connections within the centrifuge.4. The continuous flow centrifuge of further comprising one or more main ball bearings integrated to support the centrifuge and aid in rotation of the centrifuge.5. The continuous flow centrifuge of further comprising one or more thrust roller bearings to further aid in the rotation of the device.6. The centrifuge of further comprising a pump impeller positioned at the egress to pull ...

ISOLATION TUBE

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. An assembly comprising:a retainer within a body of a separation container comprising an annular wall defining a central opening; anda plunger comprising a longitudinal member defining a longitudinal axis; andwherein the central opening of the retainer is configured to receive the plunger therethrough; andwherein the retainer is configured to releasably engage the plunger to hold the plunger at a predetermined position.2. The assembly of claim 1 , wherein the retainer further comprises at least one retaining member claim 1 , wherein the plunger further comprises at least one locking member claim 1 , and wherein the at least one retaining member of the retainer is configured to releasably engage the at least one locking member of the plunger.3. The assembly of claim 2 , wherein the at least one retaining member comprises at least one support projection extending from the annular wall claim 2 , wherein the at least one retaining member is configured to engage the plunger.4. The assembly of claim 3 , wherein the annular wall defines a circumferential direction in a plane spanning the central opening and oriented about the central opening and an axial direction oriented perpendicular to the plane claim 3 , and wherein the at least one support projection defines a circumferential wall that is longer in the ...

ISOLATION TUBE

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. An assembly comprising: a body, the body defining an internal chamber, wherein the body defines an opening at a first end, and wherein the body is configured to receive a sample within the internal chamber; and', 'a seal attached to the body and disposed across the opening, wherein the seal is configured to seal the opening of the body; and, 'a separation container comprisingan end cap disposed at the first end of the body and removably connected to the body, wherein the seal is positioned between the end cap and the body.2. The assembly of claim 1 , wherein the body further defines an annular surface around the opening claim 1 , and wherein the seal is attached to the annular surface.3. The assembly of claim 2 , wherein the end cap defines a support surface configured to be positioned parallel to the annular surface of the body with the seal being disposed between the support surface and the annular surface.4. The assembly of claim 1 , wherein the seal comprises a membrane.5. The assembly of claim 4 , wherein the seal comprises a foil sheet.6. The assembly of claim 1 , wherein the seal is welded to the body of the separation container.7. The assembly of claim 1 , wherein the end cap is a centrifuge adapter comprising at least one of a flat distal end and a tapered portion configured to engage a ...

ISOLATION TUBE

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. A separation container comprising:a body defining an internal chamber, wherein the body defines a first opening at a first end and a second opening at a second end, and wherein the body is configured to receive a sample within the internal chamber;a seal disposed across the first opening, such that the seal is configured to seal the first opening of the body;a plunger movably disposed at least partially inside the internal chamber, wherein the plunger is configured to be actuated to open the seal and extract a portion of the sample; anda flexible sealing member at least partially covering the second opening, wherein at least a portion of the plunger is configured to extend at least partially into the flexible sealing member, such that compression of the flexible sealing member is configured to actuate the plunger.2. The separation container of claim 1 , wherein the flexible sealing member comprises a flange defining an annular surface configured to engage the body.3. The separation container of claim 2 , wherein the flexible sealing member further comprises a wall extending from the flange claim 2 , and wherein an angle between the flange and the wall is greater than or equal to 90 degrees when the flexible sealing member is in an unactuated position.4. The separation container of claim 3 , wherein ...

Centrifuge rotor

The invention relates to a rotor 10 of a centrifuge 100, having a receiving chamber 18 for samples to be centrifuged, a concentrically mounted seat 20 which is associated with a support 106 of a drive shaft 104 of said centrifuge 100, a lid 40 which limits the receiving chamber 18 at the top, which is mounted concentrically relative to the rotor and which has, on its side remote from the receiving chamber 18, a handle 44 for carrying the rotor and the lid 40, and a locking mechanism 50, 34 b of lid 40 and rotor, which locking mechanism 50, 34 b comprises a locking element 50 which can be moved between a locking position and an unlocking position thereof. In accordance with the invention, part of the handle 44 is adapted to be movable and is operatively connected to a retaining element 48 b , 48 c , which retaining element 48 b , 48 c can be moved, by means of the handle 44, between a first position which prevents actuation of the locking element 50, and a second position which releases the locking element 50.

CHAMBER FOR CENTRIFUGAL SEPARATION AND METHOD FOR CENTRIFUGAL SEPARATION USING THE SAME

A chamber for centrifugal separation includes a main body including a first opening and a second opening opposite to the first opening, a first cover coupled to the main body to close the first opening and including a first injection port to inject a material, a second cover coupled to the main body to close the second opening and including a second injection port to inject a material, and a filter device provided inside the main body and interposed between the first injection port and the second injection port, to prevent the material injected into the first injection port from being mixed with the material injected into the second injection port. 1. A chamber for centrifugal separation , comprising: 'a first cover coupled to the main body to close the first opening, and including a first injection port to inject a material;', 'a main body including a first opening and a second opening opposite to the first opening;'}a second cover coupled to the main body to close the second opening, and including a second injection port to inject a material; anda filter device provided inside the main body and interposed between the first injection port and the second injection port, to prevent the material injected into the first injection port from being mixed with the material injected into the second injection port.2. The chamber of claim 1 , wherein the filter device includes:a filter to filter a material; anda first filter supporting member to mount the filter on the first filter supporting member, a position of the first filter supporting member being fixed to an inner surface of the main body.3. The chamber of claim 2 , wherein the main body includes:a step part protruding inward from the inner surface of the main body, 'a second filter supporting member extending from the first filter supporting member in a direction from the first injection port toward the second injection port, and', 'wherein the filter device further includeswherein the position of the first filter ...

ROTOR FOR CENTRIFUGE AND CENTRIFUGE COMPRISING THE SAME

A rotor for a centrifuge includes a main body to rotate about a rotating axis extending in a vertical direction, a first chamber coupled to the main body to be rotatable about a first axis perpendicular to a direction parallel to the vertical direction, and having a first space to receive a material, and a second chamber coupled to the main body to be rotatable about a second axis parallel to the first axis and having a second space to receive a material. The first space and the second space have mutually different sizes, and the center of mass of the rotor is positioned on the rotating axis. 1. A rotor for a centrifuge , the rotor comprising:a main body configured to rotate about a rotating axis extending in a vertical direction;a first chamber coupled to the main body to be rotatable about a first axis perpendicular to a direction parallel to the vertical direction, and having a first space to receive a material; anda second chamber coupled to the main body to be rotatable about a second axis parallel to the first axis, and having a second space to receive a material,wherein the first space and the second space have mutually different sizes, and the center of mass of the rotor is positioned on the rotating axis.2. The rotor of claim 1 , wherein the main body includes:a first opening part that is open to place the first chamber;a second opening part that is open to place the second chamber;a pair of first protrusions formed to face each other while extending in the first axis from an inner surface of the first opening part; anda pair of second protrusions formed to face each other while extending in the second axis from an inner surface of the second opening part, andwherein the first chamber includes:a pair of first grooves to insert the pair of first protrusions, respectively; anda pair of second grooves to insert the pair of second protrusions, respectively.3. The rotor of claim 2 , wherein the first groove and the second groove are open in sides corresponding ...

METHOD AND APPARATUS FOR CONTINUOUS REMOVAL OF SUB-MICRON SIZED PARTICLES IN A CLOSED LOOP LIQUID FLOW SYSTEM

A centrifuge rotor having a curved shape is offset on a spinning rotor base and creates contiguous areas of low to high centrifugal force depending on the distances from the axis of the rotor base and a method of separating components in a fluid based upon a difference in density of the components, the method comprising the steps of providing to a rotor as described herein the fluid containing the mixed together components to be separated based upon the difference in density of the mixed together components; continuously flowing the components in the fluid to the rotor through an input tube connected to the input port while the rotor is spinning about a centrifugal axis of rotation; separating the components in the fluid into fractions based upon the difference in density of the mixed together components with the use of centrifugal force when the rotor is spinning; collecting components having i) a first density via a first tube connected to the output port at the first end on the rotor, ii) a second density via a second tube connected to the output port at the second end on the rotor, iii) a third density via a third tube connected to the output port at the junction on the rotor and iv) a fourth density via a fourth tube connected to the output port between the input port and the output port at the first end. 1. A rotor comprising:a hollow curved housing that has an inner wall and an outer wall, a top, a bottom and a first end and a second end wherein the inner wall is radially closer to an axis of rotation as compared to the outer wall;the hollow curved housing being formed of a curved first rotor element that terminates at the first end of the curved housing and a curved second rotor element that terminates at the second end of the curved housing wherein the curved housing between the curved first rotor element and the curved second rotor element includes a junction that creates a change in an inner and outer radius of the first rotor element as compared to an ...

A SYSTEM AND METHOD FOR CALIBRATING A CENTRIFUGE

A sample holder for use in a centrifuge, the sample holder being generally planar and comprising: an aperture or recess for releasably retaining a sample storage member including a sample chamber adapted to contain a volume of liquid; a centre point around which the holder will rotate during use; and one or more calibration features, wherein the calibration feature(s) comprise one or more outer edges, which lie on the side of the or each calibration feature which is furthest from the centre point, and the one or more outer edges comprise a series of radially spaced-apart outer edge portions or positions which are spaced at different distances from the centre point as a function of angular position around the centre point. 1. A sample holder for use in a centrifuge , the sample holder being generally planar and comprising:an aperture or recess for releasably retaining a sample storage member including a sample chamber adapted to contain a volume of liquid;a centre point around which the holder will rotate during use; andone or more calibration features, wherein the calibration feature(s) comprise one or more outer edges, which lie on the side of the or each calibration feature which is furthest from the centre point, and the one or more outer edges comprise a series of radially spaced-apart outer edge portions or positions which are spaced at different distances from the centre point as a function of angular position around the centre point.2. A sample holder according to claim 1 , comprising a calibration feature having a continuous outer edge which has a plurality of outer edge portions or positions which are at varying distances from the centre point.3. A sample holder according to claim 2 , wherein the outer edge of the calibration feature is curved and the distance of the outer edge from the centre point varies continuously or substantially continuously along its length.4. A sample holder according to claim 2 , wherein the outer edge of the calibration feature ...

Fixed Angle Rotor

A fixed-angle rotor for centrifuges includes stiffening ribs on the lower side of its rotor body. Its rotational energy is comparatively low during operation even at high speeds, whereby safety is noticeably increased without the need for a reinforced armored vessel in the centrifuge that is equipped therewith. At the same time, the drive power required to drive the fixed-angle rotor remains low. The fixed-angle rotor also withstands extreme loads over a long period of time. In addition, the fixed-angle rotor can be manufactured cost-effectively, because no additional components are required; rather, the stiffening ribs can also be manufactured during the manufacture of the rotor body. Finally, very thin rotor shells can also be used, which improves the temperature control of the samples, because the fixed-angle rotor has very good structural stability, especially in the main load directions. 1. A fixed-angle rotor for a centrifuge , comprising: an upper side and an oppositely arranged lower side and', 'a hub which is arranged around a rotor axis;, 'a rotor body having'}at least two holders for samples to be centrifuged arranged in the rotor body around the rotor axis, wherein the holders have openings on the upper side for introducing samples; andat least one stiffening rib formed on the lower side of the rotor body.2. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs in a radial manner in relation to the rotor axis.3. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs in direction of the holder.4. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs in direction of a central axis of the holder.5. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs between one of the at least two holders and the hub.6. The fixed-angle rotor according to claim 5 , ...

SWING-OUT CENTRIFUGE

A centrifuge has a hollow shell and a rotor supported by the shell. A motor is coupled to the rotor to rotate the rotor relative to the shell. Plural receptacles are formed in the rotor and respective tube holders are pivotably mounted in respective receptacles in a vertical orientation. The tube holders hold one or more test tubes containing material to be centrifuged, and the tube holders pivot within their receptacles to a horizontal orientation under the influence of spinning the rotor. The rotor can be formed with a top surface into which the receptacles are established, with the tube holders (and test tubes) being substantially completely below the top surface in the horizontal orientation to reduce friction with the air while spinning. 1. An apparatus , comprising:at least one hollow rotatable member formed with plural receptacles;plural tube holders pivotably coupled to respective ones of the receptacles, at least some tube holders being formed with at least one tube cavity into which a respective tube holding material can be disposed, the tube holders assuming a vertical orientation when the rotatable member does not rotate with respective tops of the tube holders being vertically above respective bottoms of the tube holders; andat least one motor coupled to the rotatable member to rotate the rotatable member to thereby cause the tube holders to pivot in their respective receptacles to a horizontal orientation, in which the respective tops of the tube holders are radially inward of the respective bottoms of the tube holders and the tube holders are disposed within an interior of the rotatable member to shelter the tube holders from wind resistance as the rotatable member rotates.2. The apparatus of claim 1 , comprising the respective tubes.3. The apparatus of claim 1 , wherein the rotatable member is formed with a top surface into which the receptacles are established claim 1 , the tube holders being substantially completely below the top surface in the ...

MICROFLUIDIC ROTOR DEVICE

Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer. The second layer may be substantially absorbent to infrared radiation. The second layer and the first layer may collectively define a set of wells. The first layer may define a base for each well of the set of wells. The second layer may define an opening for each well of the set of wells. At least one of the first layer and the second layer may define a sidewall for each well of the set of wells. 1. An apparatus , comprising:a first layer being substantially transparent; anda second layer coupled to the first layer, the second layer being substantially absorbent to infrared radiation,the second layer and the first layer collectively defining a set of wells, the first layer defining a base for each well of the set of wells, the second layer defining an opening for each well of the set of wells, at least one of the first layer and the second layer defines a sidewall for each well of the set of wells.2. The apparatus of claim 1 , further comprising a third layer coupled to the second layer claim 1 , the third layer defining a port configured to receive a fluid claim 1 , the third layer being substantially transparent claim 1 , wherein a channel establishes a fluid communication path between the port and the set of wells.3. The apparatus of claim 2 , wherein the first layer and the third layer are each independently transparent.4. The apparatus of claim 1 , wherein substantially transparent includes light transmission of at least one of ultraviolet light claim 1 , visible light claim 1 , and infrared radiation.5. The apparatus of claim 1 , wherein the second layer is substantially absorbent to at least one of mid-infrared radiation and near-infrared radiation.6. The ...

Methods, systems and apparatus for manipulating particles

An apparatus for manipulating particles includes: a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube connecting to a drum at the rear side of the rotor; a flexible conduit residing in the guide tube; and first and second elongate passageways for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.

MODULAR CENTRIFUGE DEVICES AND METHODS

A modular centrifuge device for separating fluid samples, including a housing having a modular power assembly mechanism for rotating samples with manual or electric power. A manual centrifuge device, including a housing having a power assembly mechanism for rotating samples with manual power, and a speed indicator for indicating if a predetermined speed has been reached and a time indicator for indicating if a predetermined or calculated time has been reached for rotating said samples operatively connected to the device. A method of centrifuging samples, by selecting a manual power mode or electric power mode on a centrifuge, rotating samples at a predetermined speed for a predetermined or calculated time, alerting a user that the predetermined speed and predetermined or calculated time have been achieved, and obtaining separated samples. 125-. (canceled)26. A centrifuge device for separating fluid samples , comprising:a base;a rotatable sample carrier having a holder configured to securably hold a sample container, the rotatable sample carrier being enclosed in the base;a shaft coupled to the sample carrier such that the sample carrier is configured to rotate in unison with the shaft;a power assembly selectively coupled to the shaft, the power assembly extending upward from the base;an electric motor selectively coupled to the shaft; anda manual power input device;wherein the shaft is selectively rotatable by manual power and electric power via the power assembly and the electric motor, respectively.27. The centrifuge device of claim 26 , wherein the centrifuge device is free-standing.28. The centrifuge device of claim 26 , wherein the centrifuge device is comprised of modular components.29. The centrifuge device of claim 26 , wherein the centrifuge device is configured to switch between manual power and electric power via user toggling to select manual power or electric power.30. The centrifuge device of claim 26 , wherein the centrifuge device is configured to ...

CENTRIFUGATION METHOD AND CENTRIFUGATION DEVICE

According to one exemplary embodiment of the present invention, a method of centrifuging a mixture using a syringe which has a nozzle at one end, comprises the steps of taking the mixture in the syringe, first centrifuging the mixture in the syringe, discharging one part of the mixture which is adjacent to the nozzle after the first centrifuging, second centrifuging the mixture in the syringe after reversing the syringe, and discharging another part of the mixture which is adjacent to the nozzle after the second centrifuging. 1. A method of centrifuging a mixture using a syringe which has a nozzle at one end , the method comprising the steps of:taking the mixture in the syringe;first centrifuging the mixture in the syringe;discharging one part of the mixture which is adjacent to the nozzle after the first centrifuging;second centrifuging the mixture in the syringe after reversing the syringe; anddischarging another part of the mixture which is adjacent to the nozzle after the second centrifuging.2. The method of claim 1 , wherein the syringe is reversed in the second centrifuging claim 1 , thereby the nozzle of the syringe is directed toward or in opposite to a rotating center of a centrifuging device.3. The method of claim 1 , wherein the nozzle of the syringe is directed opposite to the rotating center during the first centrifuging claim 1 , and is directed to the rotating center during the second centrifuging.4. The method of claim 1 , wherein the syringe includes a barrel having the nozzle at one end and a plunger entering through the other end of the barrel to move straightly in the barrel claim 1 , andwherein the nozzle is sealed during the first centrifuging and the second centrifuging.5. The method of claim 1 , wherein the one part discharged by the first centrifuging contains red blood cells and the another part discharged by the second centrifuging contains blood plasma claim 1 , andwherein target element, which is remained in the syringe after discharging ...

METHOD FOR COLLECTING A DESIRED BLOOD COMPONENT AND PERFORMING A PHOTOPHERESIS TREATMENT

An improved method for separating whole blood into components and collecting a desired blood component. The method allows a desired blood component to be subjected to centrifugal forces within a separator for prolonged periods of time, yielding a cleaner cut and higher yield of the desired blood component. Whole blood is drawn from a source and pumped into a separator, the undesired blood components are removed from the separator at rates so as to build up the desired blood component in the separator. The desired blood component is only removed after a predetermined amount of the desired blood component has built up in the separator. It is preferred that the desired blood component be buffy coat and that the method be used to perform photopheresis treatments. In another aspect, the invention is a method of performing a full photopheresis treatment to treat diseases in a reduced time, preferably less than about 70 minutes, and more preferably less than about 45 minutes. 114-. (canceled)15. An apparatus for carrying out a method for separating and collecting at least one blood component , the apparatus comprising a disposable kit , the disposable kit comprising: an inlet port;', 'a first outlet port; and', 'a second outlet port;, 'a centrifuge bowl comprisinga treatment bag fluidly connectable with the first outlet port of the centrifuge bowl; anda return bag fluidly connectable with the second outlet port of the centrifuge bowl;a hematocrit sensor in a flow path between the first outlet port of the centrifuge bowl and the treatment bag; anda cassette for controlling the movement of blood fluids pumped to the centrifuge bowl; combining an anticoagulant agent with whole blood at a selected ratio of the anticoagulant agent to the whole blood;', 'pumping at least a portion of the combination of the whole blood and the anticoagulant agent through the cassette and into the centrifuge bowl through the inlet port of the centrifuge bowl;', 'operating the centrifuge bowl to ...

Centrifuge having onboard imaging system

A centrifuge ( 1 ) includes: a motor ( 4 ) having a rotor ( 3 ); an imaging system ( 2 ) torsionally connected to the rotor; a sample holder torsionally connected to the imaging system; and a light source for illuminating the sample holder. The imaging system ( 2 ) includes: a image sensor in optical communication with the sample holder; and a data link for transmitting image data. A centrifuge test includes: spinning a reservoir core sample in a sample holder of a rotor, wherein an imaging system is torsionally connected to the rotor; and collecting image data of the sample holder with the imaging system while spinning.

Methods, Systems and Apparatus for Separating Components of a Biological Sample

Described herein are methods, systems and apparatus for separating components of a biological sample; as well as methods of using compositions prepared by same. In some embodiments, the present invention provides a method for separating components of a biological sample, the method comprising: introducing a biological sample having a plurality of components to a tube comprising: a lumen; a proximal end; a distal end; an interior wall; and an exterior wall; applying a force to said tube for a time sufficient to separate said plurality of components; and agitating said tube at an angle of from about 5° to about 60°. 1. A method for separating components of a biological sample , the method comprising: a lumen;', 'a proximal end;', 'a distal end;', 'an interior wall; and', 'an exterior wall;, 'introducing a biological sample having a plurality of components to a tube comprisingapplying a centrifugal force to said tube for a time sufficient to separate said plurality of components; andagitating said tube at an angle of from 5° to 60°.2. (canceled)3. The method according to claim 1 , wherein the tube further comprises a separation barrier.4. The method according to claim 3 , wherein the separation barrier comprises a gel claim 3 , a solid float or a combination thereof.5. The method according to claim 4 , wherein the separation barrier comprises a gel and wherein the gel comprises a thixotropic gel.619.-. (canceled)20. The method according to claim 3 , wherein the tube is agitated for a time sufficient to provide a plasma fraction having a straw color with a pinkish hue.21. The method according to claim 3 , wherein the tube is agitated for a time sufficient to provide a plasma fraction having a hue angle claim 3 , h claim 3 , in the CIELAB system of from 310 to 350 degrees.22. The method according to claim 3 , wherein the tube is agitated for a time sufficient to create a visually perceivable foam layer on a surface of the plasma fraction.23. (canceled)24. The method ...

CRISPR/CAS9 IN VITRO KIT

A kit includes reagents and materials for students to make gRNA and Target DNA, cut Target DNA with Cas9 guided by the gRNA, and visualize the uncut and cut the Target DNA on an agarose gel. The kit may include a shipping box that is able to withstand transport of the reagents and materials, reagents and materials needed to perform the desired curriculum, and the curriculum necessary for using the kit. Additional curriculum may be included with extension activities as desired. 1. A CRISPR-Cas9 kit comprising a sealable package including:parafilm for mixing the loading dye with DNA thereon;0.2 milliliter tubes;1.5 milliliter tubes;screw-cap tubes;falcon conical centrifuge tubes; andreagents selected from a group consisting of: forward primer, reverse primer, gene specific oligo, tail oligo, PCR (master mix), T4 DNA polymerase, dNTPs, NEB buffer 2.1, T7 RNA polymerase, NTPs, buffer, DTT, RiboGuard RNase Inhibitor, DNase I, ammonia acetate, EtOH, RNA storage solution, Cas9, NEBuffer 3.1, proteinase K, agarose, TAE buffer, DNA gel stain, DNA ladder, loading dye, and nuclease-free water.2. The kit of claim 1 , further comprising at least one of:tube labels;bag and box labels; andresealable bags.3. The kit of claim 2 , further comprising at least one ofan insulated container; anddry ice.4. A method of performing CRISPR-Cas9 techniques claim 2 , comprising{'claim-ref': {'@idref': 'CLM-00001', '#text': 'claim 1'}, '#text': 'providing a kit according to ; and'}{'claim-text': ['annealing oligos and making the DNA Template,', 'gRNA synthesis, DNase I treatment, and RNA precipitation, and', 'in vitro nuclease assay with CRISPR-Cas9.'], '#text': 'performing at least one of the following CRISPR-Cas9 techniques:'}8. The method of claim 7 , wherein the technique of gRNA synthesis claim 7 , DNase I treatment claim 7 , and RNA precipitation further comprises the following steps:centrifuging the gRNA tube 15 min. at 4° C. at 12,000 rpm;pouring out supernatant;transferring 1 mL of RNA ...

TRI-AXIAL CENTRIFUGE APPARATUS WITH ELECTRICAL SENSOR, ACOUSTIC SENSOR, AND X-RAY INSTRUMENT

A tri-axial centrifuge apparatus for testing of petro-physical properties of a test sample includes a tri-axial sample holder located within an inner bore of a cell body. An axial pressure fluid supply line delivers an axial pressure fluid to apply an axial pressure on the test sample. A confining pressure fluid supply line delivers a confining pressure fluid to apply a biaxial confining pressure on the test sample. A test fluid holder contains test fluid and is static relative to the cell body. The axial pressure fluid, the confining pressure fluid, and the test fluid are contained in separate flow systems. A centrifuge has a window that is located on a portion of a path of the tri-axial sample holder. The tri-axial sample holder is loaded in the centrifuge and spinning with the centrifuge. An x-ray instrument is static and is aligned with the window of the centrifuge. 1. A tri-axial centrifuge apparatus for testing of petro-physical properties of a test sample and gathering of geo-mechanical information , the tri-axial centrifuge apparatus having:a tri-axial sample holder located within an inner bore of a cell body;an axial pressure fluid supply line operable to deliver an axial pressure fluid to a fluid chamber of a piston assembly to apply an axial pressure on the test sample;a confining pressure fluid supply line operable to deliver a confining pressure fluid to a cell chamber of the cell body to apply a biaxial confining pressure on the test sample;a test fluid holder containing test fluid, the test fluid holder being sealingly secured to the cell body and static relative to the cell body, where the axial pressure fluid, the confining pressure fluid, and the test fluid are contained in separate flow systems;a centrifuge with a window that is located on a portion of a path of the tri-axial sample holder, where the tri-axial sample holder is loaded in the centrifuge and spinning with the centrifuge;an x-ray instrument, where the x-ray instrument is static and is ...

DEVICE FOR EXTRACTING PLATELET RICH PLASMA

The present invention relates to a platelet rich plasma (PRP) extracting device and extracting method using the same, and more particularly, to a platelet rich plasma (PRP) extracting device capable of quickly and effectively extracting the highly concentrated PRP from centrifuged blood by a simple manipulation. 1. A device for extracting platelet rich plasma (PRP) , the device comprising:a main body unit comprising an upper accommodation space having a lower end portion having an inclined surface having a width gradually decreasing in a downward direction, a lower accommodation space disposed below the upper accommodation space and having an upper end portion having a width gradually decreasing in an upward direction, and a bottleneck part that is a passage connecting the upper accommodation space and the lower accommodation space;an upper cover disposed above the main body unit and retractably coupled to the main body unit; anda lower cover disposed below the main body unit and retractably coupled to the main body unit to seal the lower accommodation space,wherein a syringe guide having a hollow tube structure, which extends downward from a protruding-type syringe insertion hole for inserting a syringe, and disposed inside the upper accommodation space is defined at a central portion of a top surface of the upper cover,wherein, a syringe nozzle coupling hole having a protruding structure for being coupled with the syringe nozzle is defined at a position spaced apart from the syringe insertion hole, and a PRP extraction tube having a through hole structure, which extends downward from the syringe nozzle coupling hole in the upper accommodation space and having a lower inclinedly cut cross-section, is disposed in the upper accommodation space,wherein, when the upper cover descends, a lower end of the syringe guide blocks the bottleneck part and a space above the bottleneck part, and, at the same time, as the lower inclinedly cut cross-section of the PRP extracting ...

APPARATUS, SYSTEM AND METHOD FOR PERFORMING AUTOMATED CENTRIFUGAL SEPARATION

Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the microfluidic device. The integrated fluidic processing cartridge may include a supernatant chamber the extraction of a supernatant thereto, and a diluent chamber for diluting a suspension collected in the centrifugation chamber. 1. A method of performing centrifugal separation and microfluidic processing using an integrated fluidic processing cartridge; a macrofluidic centrifugation chamber, wherein a distal region of the macrofluidic centrifugation chamber is configured to collect a sediment under the application of centrifugal force;', 'a microfluidic device having an inner surface and an outer surface, wherein the inner surface is attached to a lateral surface of the macrofluidic centrifugation chamber, and wherein the microfluidic device comprises one or more fluidic components that are configured to be actuated through the outer surface;', 'wherein a sediment extraction port is provided within the macrofluidic centrifugation chamber and wherein the sediment extraction port is in fluid communication, through the lateral surface, with a sediment extraction channel of the microfluidic device for extraction of the sediment to the microfluidic device;, 'the integrated fluidic ...

CENTRIFUGE BOWL AND BLOOD CENTRIFUGE SYSTEM

A centrifuge bowl is configured to separate a first component and a second component in a sample. The centrifuge bowl includes a shell, a core, a separation cavity, and a stator head. The shell includes an upper shell part, a middle shell part, a lower shell part, and a bottom shell part. The core is arranged in the shell. The separation cavity is arranged between the lower shell part and the core. The stator head is arranged on the shell and includes an input tube and an output tube. The sample enters the separation cavity via the input tube. When the shell and the core rotate on a rotation axis, the sample in the separation cavity is separated into the first component and the second component according to a magnitude of an inertial force. In addition, a blood centrifuge system including the above centrifuge bowl is provided. 1. A centrifuge bowl configured to separate a first component and a second component in a sample , the centrifuge bowl comprising:a shell comprising an upper shell part, a middle shell part, a lower shell part, and a bottom shell part, wherein the middle shell part connects the upper shell part and the lower shell part, and the lower shell part connects the middle shell part and the bottom shell part;a core arranged in the shell;a separation cavity arranged between the lower shell part and the core; anda stator head arranged on the shell and comprising an input tube and an output tube,wherein the sample enters the separation cavity via the input tube, andwhen the shell and the core rotate on a rotation axis, the sample in the separation cavity is separated into the first component and the second component according to a magnitude of an inertial force.2. The centrifuge bowl according to claim 1 , wherein the separation cavity is defined as being surrounded by the core claim 1 , the middle shell part claim 1 , the lower shell part claim 1 , and the bottom shell part.3. The centrifuge bowl according to claim 1 , wherein when a first inertial ...

METHOD AND DEVICE FOR PROCESSING TISSUES AND CELLS

Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s). 1173-. (canceled)174. A system for processing samples comprising:a motor coupled to a vertically oriented rotatable chuck;a support plate containing a plurality of rotatable carriages positioned radially about the support plate, wherein the support plate is mounted on or secured to the rotatable chuck;at least one microfluidic chip disposed on one of the rotatable carriages, the at least one microfluidic chip defining a fluid path formed by one or more microfluidic channels disposed therein and extending between a first port of the microfluidic chip to a second port located at an opposing end of the microfluidic chip;a first sample holding chamber and a second sample holding chamber disposed in the rotatable carriage, the first sample holding chamber fluidically coupled to the at least one microfluidic chip via the first port and the second sample holding chamber fluidically coupled to the at least one microfluidic chip via the second port; anda filter interposed between the at least one microfluidic chip and one of the first sample holding chamber or the second sample holding chamber, wherein the filter ...

Blood Component Separation Device

A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor, and collecting platelets, includes: an operation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, wherein the operating unit sets the predicted platelet recovery rate calculated from any the hematocrit value and any the platelet concentration to be smaller by a predetermined value a when the blood donor is female than that when the blood donor is male. 1. A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor , and collecting platelets , comprising:an operation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, whereinthe operating unit sets the predicted platelet recovery rate calculated from the hematocrit value and the platelet concentration to be smaller by a predetermined value when the blood donor is female than that when the blood donor is male.2. The blood component separation device according to claim 1 , whereinthe predetermined value increases as the recommended processing amount of the blood increases.3. The blood component separation device according to claim 1 , whereina) a centrifugal separation step of introducing the blood into a centrifuge, and separating the blood into a plurality of blood components;b) a circulation flow step of introducing plasma among the separated blood components into the centrifuge together with the ...

COMPOSITE LIQUID BAG SYSTEM HOLDER

Embodiments of a system box for holding a bag system and methods for separating composite liquids are described. In embodiments, a bag system may be a blood bag system used to collect blood, separate the blood into components, store the components, and utilize the components in patients. The system box may hold the blood bag system. Processes can then be performed to separate components from the blood. 1. A system box for holding a bag system for processing biologic fluids on a centrifuge , the system box comprising:a first chamber comprising a first opening;a second chamber comprising a second opening;a lid movable from an open position to a closed position, the lid comprising an interior surface and an exterior surface, wherein when the lid is in the closed position the interior surface covers at least a portion of the first opening;a first ridge on the inside surface of the lid;a recess, wherein when the lid is in the closed position the first ridge is positioned above the recess; anda second ridge on the inside surface of the lid, wherein when the lid is in the closed position the second ridge is positioned over at least a portion of a channel.2. The system box of claim 1 , wherein the system box is shaped to fit into a centrifuge apparatus.3. The system box of claim 2 , wherein the system box is wedge shaped.4. The system box of claim 1 , wherein an opening of the recess is in the channel.5. The system box of claim 4 , further comprising a sensor positioned in the channel.67-. (canceled)8. The system box of claim 1 , wherein when tubing with a frangible is placed in the channel and the lid is moved from an open position to a closed position claim 1 , the first ridge breaks the frangible.9. The system box of claim 1 , wherein when tubing is placed in the channel and the lid is in the closed position claim 1 , the second ridge contacts a portion of the tubing in the channel to maintain the tubing in the channel.10. The system box of claim 5 , wherein the sensor ...

CENTRIFUGE HAVING TUBE HOLDERS

A centrifuge device operably configured to simultaneously spin multiple sample tubes at different g-forces during a single centrifugation cycle. The centrifuge device includes a base and a rotatable member disposed within the base and configured as a rotor. The rotatable member includes a plurality of receptacles and a center portion, and wherein each of the receptacles is spaced equally apart from the center portion. The centrifuge also includes a first tube holder selectively inserted within one of the receptacles, wherein the first tube holder includes a first tube therein and a second tube holder selectively inserted within another one of the receptacles, wherein the second tube holder includes a second tube therein. The first tube is operably configured to be spun at a different relative centrifugal force than the second tube. 1. A centrifuge device comprising:a base;a rotatable member disposed within the base and configured as a rotor, wherein the rotatable member includes a plurality of receptacles and a center portion, and wherein each of the receptacles is spaced equally apart from the center portion;a first tube holder selectively inserted within one of the receptacles, wherein the first tube holder includes a first tube therein;a second tube holder selectively inserted within another one of the receptacles, wherein the second tube holder includes a second tube therein;wherein the radial distance between the first tube and the center portion of the rotatable member is less than the radial distance between the second tube and the center portion of the rotatable member; andwherein the first tube is operably configured to spin at a different relative centrifugal force than the second tube.2. The centrifuge device of claim 1 , wherein each of the first and second tube holders includes a body and a pair of opposing members extending axially from the body.3. The centrifuge device of claim 2 , wherein each of the receptacles includes one or more angled ...

CENTRIFUGAL PISTON AND CENTRIFUGAL DEVICE COMPRISING SAME

A centrifugal piston according to an embodiment comprises: a piston body defining a path which extends from the front of the piston to the rear of the piston, and through which substances at the front of the piston can move to the rear of the piston; and a valve disposed on the path and configured to selectively open or block the path, wherein, during centrifugation in which centrifugal force acts on the piston, the substances at the front of the piston are centrifuged while the valve is blocking the path, and, when an external force is applied to the piston while the centrifugal force does not act on the piston, the valve moves freely relative to the piston body, and when the valve opens the path, at least a portion of the substances at the front of the piston can move to the rear of the piston. 1. A piston for centrifugation , comprising:a piston body having a passage defined therein, the passage extending from a front to a rear of the piston, and materials at the front of the piston being movable to the rear of the piston through the passage; anda valve disposed in the passage to selectively open or interrupt the passage,wherein during the centrifugation that involves application of a centrifugal force to the piston, the materials at the front of the piston are centrifugally separated in a state in which the valve interrupts the passage, and when an external force is applied to the piston while a centrifugal force is not applied to the piston, at least a portion of the materials at the front of the piston are movable to the rear of the piston as the valve opens the passage while freely moving relative to the piston body.2. The piston of claim 1 , wherein the center of rotation of the centrifugal force is located at the rear of the piston body claim 1 ,wherein the piston body is located inside a container that receives the piston, andwherein the piston body applies pressure to the materials at the front of the piston while moving along an inside of the container ...

Platelet collection method and platelet collection system

A platelet collection method includes a step of accommodating whole blood in a first chamber (44) and performing centrifugal separation, a step of transferring a buffy coat resulting from the centrifugal separation to a second chamber (50), and a step of performing centrifugal separation on the buffy coat. Subsequently, a step of transferring a platelet-containing component resulting from the centrifugal separation to a third chamber (52) and a step of performing centrifugal separation on the platelet-containing component are executed. Also performed in the collection method are a step of introducing a platelet additive solution into the third chamber (52) and replacing plasma resulting from the centrifugal separation and a step of collecting platelets remaining in the third chamber (52) along with the platelet additive solution.

WHOLE BLOOD SEPARATOR DEVICE AND METHOD OF USE

A whole blood separator device has a sleeve. The sleeve has a sleeve body. The sleeve body has an enlarged first proximal end portion and an enlarged second distal end portion and an intermediate cylindrical tube portion connecting the first proximal end portion and the second distal end portion. The sleeve body is configured to fit inside a test tube and receive whole blood which can be separated by centrifugation into a plasma layer in the proximal end portion, a buffy coat layer in the intermediate portion and a red blood cell portion in the distal portion. The whole blood separator device wherein at least the proximal end portion has an open end. Preferably, the distal end portion also has an open end.

BLOOD BAG SYSTEM WITH RETAINING CASSETTE

A blood bag system includes a PPP bag and a liquid drug bag which are accommodated adjacent to each other in pockets of a centrifugal drum of a centrifugal transport device. In addition, the blood bag system includes a retaining portion that retains the PPP bag and the liquid drug bag together, and includes a cassette accommodated in the pockets in a retaining state of the retaining portion. The cassette has a detachment mechanism capable of detaching at least the PPP bag. 1. A blood bag system comprising:a first bag and a second bag which are accommodated adjacent to each other in a bag accommodating portion of a centrifugal drum of a centrifugal transport device; anda cassette which has a retaining portion that retains both the first bag and the second bag and is accommodated in the bag accommodating portion in a retaining state of the retaining portion, the retaining portion having a width direction,wherein the cassette has a detachment mechanism capable of detaching at least the first bag; anda pair of frame bodies provided at both end portions of the retaining portion in a width direction, andthe pair of frame bodies protrudes from both the end portions of the retaining portion along long sides of the first bag and the second bag, and extends, with respect to the first bag and the second bag, longer than the long sides of the respective bags in directions of the long sides.2. The blood bag system according to claim 1 , whereinthe cassette includes frame bodies which are provided at both end portions of the retaining portion in said width direction and are arrangeable on walls forming the bag accommodating portion.3. The blood bag system according to claim 1 , whereinthe retaining portion includesa main body portion having a bag retaining portion capable of detachably retaining the first bag anda cover portion capable of maintaining a state of retaining the first bag in the bag retaining portion to form the detachment mechanism.4. The blood bag system according ...

CENTRIFUGAL FLUID SEPARATION DEVICE

A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve. 1. A modular cassette for separating a composite fluid into at least two component parts thereof during centrifugation , the cassette comprising:a fluid inlet portion;at least one fluid separation portion;at least one media chamber in fluid communication with the fluid separation portion;a fluid collection portion;at least one fluidic channel configured to form a fluid communication between at least two components of the cassette;at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels; andat least one heating element configured to actuate the at least one wax valve.2. The modular cassette of claim 1 , wherein at least one wax valve comprises an injection cavity.3. The modular cassette of claim 2 , wherein the injection cavity comprises at least one injection port.4. The modular cassette of claim 3 , wherein the injection cavity further comprises at least one vent.5. The modular cassette of claim 4 , wherein the injection cavity further comprises an extended portion configured to accept a volume of molten wax equal to a volume of a section of a flow channel.6. The modular cassette of claim 1 , wherein at least one fluidic channel comprises two wax valves in series.7. The modular cassette of claim 6 , wherein at least one of the two wax valves ...

BLOOD BAG SYSTEM WITH CONNECTED BLOOD BAGS

A blood bag system is provided with a PPP bag that is accommodated in a PPP bag pocket, and a liquid drug bag that is accommodated in a liquid drug bag pocket provided adjacent to the PPP bag pocket. The PPP bag includes a first internal space and a seal part that seals the periphery of the first internal space. The liquid drug bag includes a second internal space and a seal part that seals the periphery of the second internal space. A connection part that separably connects the seal part and the seal part is provided there between. 1. A blood bag system comprisinga bag body which includes a plurality of bags accommodated in a bag accommodating portion of a centrifugal transport device,wherein the bag body includes:a first bag including a first internal space and a first seal part that seals a periphery of the first internal space; anda second bag including a second internal space and a second seal part that seals a periphery of the second internal space, anda connection part that separably connects the first seal part and the second seal part is provided between the first seal part and the second seal part, andthe connection part connects only a part of a back side in an insertion direction of the bag accommodating portion on a long side of the first bag formed in a rectangular shape, and only a part of a back side in the insertion direction of the bag accommodating portion on a long side of the second bag formed in a rectangular shape.2. The blood bag system according to claim 1 , whereinthe bag accommodating portion includes a first bag accommodating portion that accommodates the first bag and a second bag accommodating portion that accommodates the second bag, andthe bag body is capable of accommodating the first and second bags, which are in a connected state, respectively in the first and second bag accommodating portions.3. The blood bag system according to claim 1 , whereinthe connection part is a connection sheet in which a sheet forming the first bag and a ...

CENTRIFUGE WITH ELASTOCALORIC COOLING AND METHOD FOR COOLING A CENTRIFUGE

The present invention relates to a centrifuge, in particular a laboratory centrifuge, comprising a rotor which is rotatably mounted in an interior of a rotor chamber and is designed to accommodate sample vessels, a drive motor to set the rotor in rotation, and a cooling device which is designed to dissipate heat from the interior of the rotor chamber via a coolant, the cooling device being designed to use an elastocaloric effect and having at least one cooling unit which comprises an elastocaloric material arranged between a counter block and a punch, the punch being designed to periodically apply a force to the elastocaloric material and then to let the elastocaloric material relax again, the cooling device being designed to transfer both heat from the elastocaloric material to the coolant and from the coolant to the elastocaloric material. The present invention also relates to a method for cooling an interior of a rotor chamber of such a centrifuge. 1. A centrifuge , comprising:a rotor rotatably mounted in an interior of a rotor chamber and being designed to accommodate sample vessels,a drive motor to set the rotor in rotation, anda cooling device designed to dissipate heat from the interior of the rotor chamber via a coolant,wherein the cooling device is designed to use an elastocaloric effect and has at least one cooling unit which comprises an elastocaloric material arranged between a counter block and a punch, the punch being designed to periodically apply a force to the elastocaloric material and then to let the elastocaloric material relax again, the cooling device being designed to transfer both heat from the elastocaloric material to the coolant and from the coolant to the elastocaloric material,wherein the cooling device comprises a cooling group which has a plurality of cooling units connected in series, the cooling units being arranged and designed such that a rotating eccentric successively applies a force to the punches of the cooling units, and ...

Centrifuge insert and carrier for centrifuge insert

The present invention relates to a centrifuge insert for sample holders and to a carrier for a centrifuge insert for sample holders. The centrifuge insert according to the invention has substantial advantages over known centrifuge inserts. These advantages are not limited to the fact that the carrier is attachable and detachable in a particularly easy and comfortable manner. It is also feasible to use different carriers for different sample holders. Furthermore, the centrifuge insert according to the invention is configured particularly light and compact so that the loading of the rotor is significantly lower for identical centrifugation powers or so that significantly higher RCA values can be used.

BEARING FOR UMBILICUS OF A FLUID PROCESSING SYSTEM

A fluid circuit for use with a fluid processing assembly, the fluid circuit comprising an umbilicus having a first end, a second end, an axis of rotation, and a cross-sectional circumference; a one-piece bearing secured to the umbilicus at a location between the first and second ends, the bearing having an axis of rotation and including an inner lumen which directly engages the umbilicus and includes a plurality of traction features, which bear against the umbilicus to prevent relative rotation of the bearing and the umbilicus; and the plurality of traction features comprising a first traction feature configured to engage the umbilicus at a first set of lengths between the first and second ends and a second traction feature configured to engage the umbilicus at a second set of lengths between the first and second ends. 1. A fluid circuit for use with a fluid processing assembly , the fluid circuit comprising:an umbilicus having a first end, a second end, an axis of rotation, and a cross-sectional circumference; a one-piece bearing secured to the umbilicus at a location between the first and second ends, the bearing having an axis of rotation and including an inner lumen which directly engages the umbilicus and includes a plurality of traction features, which bear against the umbilicus to prevent relative rotation of the bearing and the umbilicus; andwherein the plurality of traction features comprises a first traction feature which comprises a first plurality of projections disposed at a first rotational angle about the axis of rotation, the first plurality of projections defining all projections disposed on the first traction feature, and is configured to engage the umbilicus at a first set of lengths between the first and second ends, and a second traction feature which comprises a second plurality of projections disposed at a second rotational angle about the axis of rotation, the second plurality of projections defining all projections disposed on the second ...

ROTOR PLATE AND BUCKET ASSEMBLY AND METHOD FOR USING SAME

A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly. 1. A method of loading a sensor array assembly , the method comprising:applying a solution to a sensor array assembly disposed in a bucket of a rotor assembly when a stop plate of the rotor assembly is in a closed position;moving the stop plate to an open position;spinning the rotor assembly, the bucket rotating to a positive angle relative to a plane of rotation of the rotor assembly;moving the stop plate to the closed position; andspinning the rotor assembly, the bucket rotating to a horizontal or negative angle relative to the plane of rotation of the rotor assembly.2. The method of claim 1 , wherein the rotor assembly comprises:a rotor plate to rotate around a first axis;a bucket rotatably attached to the rotor plate and to rotate around a second axis; anda stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.3. A method of configuring a rotor assembly claim 1 , the method comprising:inserting a tip into a ring of a stop plate of the rotor assembly, the tip preventing the stop plate from moving;rotating a rotor plate of the rotor assembly relative to the stop plate; andremoving the tip from the ring.4. The method of claim 3 , wherein the stop plate includes a wing to engage a bucket rotatably coupled to the rotor plate when the rotor plate is rotated.5. The method of claim 3 , wherein the stop plate ...

Rotor for centrifuge and centrifuge

When this centrifuge is operated, local stress applied to a liquid-feeding groove formed in the upper surface of a rotor core is averaged to minimize deformation of the rotor core. A rotor core, which is mounted inside a rotor used for continuous centrifugation, has a columnar solid section, blades expanding radially outward from the solid section, and a disc section extending radially outward from the upper surface of the solid section, the upper surface of the rotor core being provided with a liquid-feeding grove that continues radially outward from the center vicinity to the outer side. A stress-mitigating groove that extends radially outward is formed in the lower surface of the liquid-feeding grove. The stress-mitigating groove is formed in a position overlapping the position of the liquid-feeding grove when the disc section is viewed along the axial direction.

Elutriation chamber for an elutriator system

The invention relates to an elutriation chamber for an elutriator system for washing and/or isolating cells, in particular thrombocytes, which elutriation chamber comprises a feed line ( 1 ) for an aqueous medium containing the cells to be washed and/or to be isolated in suspended form, and a discharge line ( 2 ) for the washed and/or isolated cells, wherein the chamber ( 5 ) is rotationally symmetrical to the axis (a), characterized in that the ratio of the area of the section through the lumen of the chamber ( 5 ) perpendicular to the axis (a) at the widest point ( 5 a - 5 b ) to the area of the section ( 1 a ) through the feed line ( 1 ) is in the range of 1,000 to 250,000.

AUTOMATED SAMPLE MIXING AND CENTRIFUGING APPARATUS

An automated sample mixing and centrifuging apparatus capable of mixing the contents of one or more centrifuge sample tubes and then centrifuging the sample tubes in the same apparatus is disclosed herein. The apparatus comprises an electric slip ring, one or more mixing actuators, a device motor, and a rotor. 1. An automated sample mixing and centrifuging apparatus comprising an electric slip ring , one or more mixing actuators , a device motor , and a rotor , wherein the apparatus is capable of both mixing the contents of one or more centrifuge sample tubes and centrifuging the sample tubes.2. The apparatus of further comprising one or more centrifuge tube buckets.3. The apparatus of wherein the electric slip ring and the one or more mixing actuators are mounted to the rotor to generate an assembly claim 2 , wherein the mixing actuators are electromechanical mixing actuators claim 2 , and wherein the electric slip ring provides power to the rotor and all electromechanical mixing actuators and electronic devices mounted to the rotor.4. The apparatus of wherein the device motor provides the necessary power used to mechanically rotate the assembly of the rotor claim 3 , mixing actuators claim 3 , and electric slip ring.5. The apparatus of wherein the device motor comprises a main shaft and wherein the rotor is mounted onto the main shaft of the device motor via a keyless bushing.6. The apparatus of wherein the electrical slip ring comprises one or more wires that transports electricity to the mixing actuators and wherein the electrical slip ring is mounted concentrically to the rotor through an extension of the main shaft via a shaft coupler.7. The apparatus of wherein the wires of the electrical slip ring are secured to an optional safety enclosure via a cable carrier to prevent interference between the wires and the rotor.8. The apparatus of wherein the one or more centrifuge tube buckets are mounted to the rotor in a swinging head configuration and are configured ...

Centrifuge

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.

Collecting Components of a Fluid

Embodiments are described for separating/collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.

POWER-LINE CONTROL OF A HAZARDOUS-ENVIRONMENT-LOCATED MACHINE FROM A SAFE ENVIRONMENT

Apparatus and associated methods related to providing safe electrical control and/or communication between a remote controller located in a safe location and interface system for a machine located in a hazardous location. The control and/or communication is provided via industrial-voltage power lines that traverse a barrier separating the safe location from the hazardous location. Control and/or communication is provided by reactively coupling to industrial power lines, which traverse the barrier, so as to superimpose a control and/or communication signal upon AC operating power provided to the machine. Each of the interface system located at the hazardous location and the remote control module located at a safe location provides such reactive coupling to the industrial-voltage power lines so as to communicate therebetween. 1. A system for interfacing with a hazardous-environment-located machine , the system comprising:an explosion-proof housing;a reactive coupler within the explosion-proof housing, the reactive coupler configured to reactively couple to an industrial-voltage power-line conductor providing AC operating power of a line frequency to the hazardous-environment-located machine;a communications interface within the explosion-proof housing and electrically coupled to the reactive coupler, the communications interface configured to receive control signals of frequencies within a communication frequency band from the industrial-voltage power-line conductor via the reactive coupler, and to generate operating signals for the hazardous-environment-located machine based on the received control signals; anda local interface electrically coupled to the communications interface and configured to couple to the hazardous-environment-located machine so as to provide the generated operating signals thereto.2. The system of claim 1 , wherein the hazardous-environment-located machine is an electric paint pump.3. The system of claim 2 , further comprising:the electric ...

Agricultural sampling system and related methods

An automated computer-controlled sampling system and related methods for collecting, processing, and analyzing agricultural samples for various chemical properties such as plant available nutrients. The sampling system allows multiple samples to be processed and analyzed for different analytes or chemical properties in a simultaneous concurrent or semi-concurrent manner. Advantageously, the system can process soil samples in the “as collected” condition without drying or grinding. The system generally includes a sample preparation sub-system which receives soil samples collected by a probe collection sub-system and produces a slurry (i.e. mixture of soil, vegetation, and/or manure and water), and a chemical analysis sub-system which processes the prepared slurry samples for quantifying multiple analytes and/or chemical properties of the sample. The sample preparation and chemical analysis sub-systems can be used to analyze soil, vegetation, and/or manure samples.

Agricultural sampling system and related methods

An automated computer-controlled sampling system and related methods for collecting, processing, and analyzing agricultural samples for various chemical properties such as plant available nutrients. The sampling system allows multiple samples to be processed and analyzed for different analytes or chemical properties in a simultaneous concurrent or semi-concurrent manner. Advantageously, the system can process soil samples in the “as collected” condition without drying or grinding. The system generally includes a sample preparation sub-system which receives soil samples collected by a probe collection sub-system and produces a slurry (i.e. mixture of soil, vegetation, and/or manure and water), and a chemical analysis sub-system which processes the prepared slurry samples for quantifying multiple analytes and/or chemical properties of the sample. The sample preparation and chemical analysis sub-systems can be used to analyze soil, vegetation, and/or manure samples.

SYSTEM FOR MULTI-PROCESSING AND SEPARATION OF BIOLOGICAL FLUIDS

A system for the processing and separation of biological fluids into components comprises an apparatus that cooperates with a disposable set, comprising a cabinet () for housing a hollow centrifugal processing chamber () of the disposable set. The cabinet comprises a plurality of side-by-side locations () for receiving a corresponding plurality of centrifugal processing chambers () in side-by-side spaced-apart relation. Each location comprises an individual drive means () for driving its centrifugal processing chamber. Remotely-actuable valves () associated with the disposable sets are located on the apparatus' cabinet in the proximity of said locations. Valve actuation provides a display of the state of actuation of the valves (). Selection of this state of actuation is arranged to control connection of the centrifugal processing chamber () of each fitted disposable set with a flexible container () of the same disposable set or another container, and to contol connection of the centrifugal processing chambers () with flexible containers of the same or other fitted disposable sets in different combinations, in particular with series and/or parallel connections. 2. The apparatus as claimed in claim 1 , wherein said valve-actuating means is arranged to provide for:{'b': 124', '20', '100', '200, '(d) the individual control of the valve(s) () associated with at least one disposable set, or all disposable sets whose centrifugal processing chambers () are received in the cabinet (), to separately control the inlet and outlet of fluid from the flexible container(s) () of the or each disposable set;'}{'b': 124', '20', '200', '200', '100, '(e) the control of the valve(s) () associated with at least two disposable sets, or of all disposable sets whose centrifugal processing chambers () are received in the cabinet (), to connect in series the outlet of at least one flexible container (), or the outlet of all but one flexible container received in the cabinet (), to the inlet ...

A Device, System and Method for the Continuous Processing and Separation of Biological Fluids Into Components

A device for the processing and separation of biological fluids into components comprises a hollow centrifugal processing chamber () fitted with an inlet/outlet head () and preferably with an axially movable piston (). The inlet/outlet head has two separate inlets/outlets, for instance an axial inlet () and a lateral outlet (). The processing chamber () is fitted with an internal flow guide () enabling operation of the device in a continuous processing mode wherein biological fluid to be processed is continuously intaken by say the axial inlet () and at the same time processed components are continuously removed via say the lateral outlet (). The continuous processing flow can be driven by an external peristaltic pump () and/or by axial displacement of a piston () in the chamber (). 22420292040. The device according to claim 1 , wherein the stationary second part () of the inlet/outlet head () comprises an external generally cylindrical body said first inlet/outlet is an axial inlet/outlet () in the inlet/outlet head () claim 1 , and said second inlet/outlet is a lateral inlet/outlet() located in a lateral side of the generally cylindrical body.314222040. The device according to wherein the processing chamber's upwardly-projecting elongated central neck () extends into the inside of the rotatable first part () of the inlet/outlet head () up to adjacent the level of the lateral inlet/outlet ().4264040. The device according to claim 2 , wherein the sealing means () of the inlet/outlet head comprise a first seal located axially on one side of the lateral inlet/outlet () and a second seal located axially on the other side of the lateral inlet/outlet ().5282828242830323012a,bba. The device according to wherein said axial separator is a central tube () that comprises a stationary axially-outer part () extending in the stationary second part () of the inlet/outlet head claim 1 , and a rotatable axially-inner part () connected to a central part of the flow guide () claim 1 ...

Centrifuge

The present invention relates to a centrifuge for cleaning a reaction vessel unit, comprising a rotor and a rotor chamber in which the rotor is positioned and supported in rotary fashion. The rotor chamber is delimited by a housing having a drainage channel beneath the rotor. Adjacent to the channel, the inner surface of the housing is embodied in the form of a funnel that feeds into the channel. This centrifuge does not require a suction pump for suctioning liquids from the rotor chamber. In addition, the centrifuge can be provided with an exchangeable module that delimits the rotor chamber and includes the rotor. The exchangeable module can be exchanged after a predetermined amount of use and replaced with another. It is also possible, however, for the module to be removed from the centrifuge, cleaned, and re-inserted.

CENTRIFUGE AND METHOD FOR LOADING A DEVICE

A sample preparation apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. In addition, the sample preparation apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles, as well as a centrifuge for loading such particles onto a sensor array. The sample preparation apparatus can further include receptacles for holding containers of reagent solutions. 1. (canceled)2. A method for automatically performing sample preparation on an integrated apparatus , comprising:preparing a particle sample in a first location of the integrated apparatus; wherein the particle sample includes a mixture of polynucleotide-enhanced particles and of particles lacking a polynucleotide;forming a polynucleotide-enhanced particle sample in a second location of the integrated apparatus by enriching the particle sample, andloading a sequencing device with the polynucleotide-enhanced particle sample in a third location of the integrated apparatus.3. The method of claim 2 , wherein preparing the particle sample comprises forming the polynucleotide-enhanced particles by amplifying the particle sample.4. The method of claim 3 , wherein forming the polynucleotide-enhanced particles comprises forming at least one target polynucleotide bound to a particle.5. The method of claim 4 , wherein forming at least one target polynucleotide bound to a particle includes using a polymerase chain reaction (PCR).6. The method of claim 4 , wherein forming at least one target polynucleotide bound to a particle includes using a recombinase polymerase amplification (RPA).7. The method of claim 3 , wherein ...

Coordinated conveyers in an automated system

Coordinated conveyors in an automated system. A system comprises a plurality of conveyors, which each comprise a plurality of segments, and one or more stations. An instruction is received to perform an operation that requires at least one station to process at least a first item held by a first segment of a first conveyor and a second item held by a second segment of a second conveyor. In response to the instruction, one or both of the first and second conveyors are moved, such that the first segment and the second segment are aligned at the station. After alignment, one or more instruments of the station process the first item and the second item.

CENTRIFUGE HAVING ONBOARD IMAGING SYSTEM

A centrifuge () includes: a motor () having a rotor (); an imaging system () torsionally connected to the rotor; a sample holder torsionally connected to the imaging system; and a light source () for illuminating the sample holder. The imaging system includes: a image sensor in optical communication with the sample holder; and a data link for transmitting image data. A centrifuge test includes: spinning a reservoir core sample in a sample holder of a rotor, wherein an imaging system is torsionally connected to the rotor; and collecting image data of the sample holder with the imaging system while spinning. 1. A centrifuge , comprising:a motor having a rotor;an imaging system torsionally connected to the rotor;a plurality of sample holders torsionally connected to the imaging system; anda light source for illuminating the sample holder, a image sensor in optical communication with the sample holder;', 'a data link for transmitting image data;', 'a relay housing having a hub and a plurality of arms extending from the hub, each arm aligned with the respective sample holder; and', 'a plurality of relay mirrors, each relay mirror for reflecting an image of the respective sample holder from a first vertical direction to a radial direction along an optical cavity of the respective arm, wherein at least one of the plurality of relay mirrors is a flat, reflective surface, comprising a shatterproof, reflective material., 'wherein the imaging system includes2. A centrifuge , comprising:a motor having a rotor;an imaging system torsionally connected to the rotor;a plurality of sample holders torsionally connected to the imaging system; anda light source for illuminating the sample holder, a image sensor in optical communication with the sample holder;', 'a data link for transmitting image data;', 'a relay housing having a hub and a plurality of arms extending from the hub, each arm aligned with the respective sample holder;', 'a plurality of relay mirrors, each relay mirror for ...

ROTOR PLATE AND BUCKET ASSEMBLY AND METHOD FOR USING SAME

A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly. 1. A method for loading particles into a sensor array of a sensor array component , the method comprising: a rotor plate to rotate around a first axis;', 'the bucket, the bucket being rotatably attached to the rotor plate and to rotate around a second axis; and', 'a stop plate to rotate around the first axis relative to the rotor plate;, 'inserting the sensor array component into a bucket of a rotor assembly of a centrifuge, the rotor assembly comprisesapplying a solution comprising the particles into the sensor array component;positioning the stop plate to permit angled spin of the bucket and sensor array component; andspinning the rotor assembly to deposit particles into the sensor array, the bucket swinging to a positive angle relative to the plane of rotation of the rotor assembly during spinning.2. The method of claim 1 , further comprising positioning the stop plate to limit angled spin of bucket and the sensor array component.3. The method of claim 2 , further comprising:spinning the rotor assembly following positioning the stop plate to limit angled spin of the bucket; andremoving remaining solution from the sensor array component.4. The method of claim 3 , wherein the angle of spin is limited to a horizontal or negative angel relative to the plane of rotation of the rotor assembly when spinning following positioning the stop plate to limit angled spin of the bucket.5. The method of claim 1 , further comprising attaching a cap to the sensor array component prior to inserting the sensor array component into the bucket.6. The ...

BUCKET INSERT FOR USE IN A CENTRIFUGE

A bucket insert for use in a centrifuge is disclosed. The bucket insert comprises an insert body, the insert body comprising a plurality of elongated receptacles for receiving elongated sample vessels. The bucket insert is configured for orienting the elongated sample vessels in a tilted orientation. In the tilted orientation, at least some of the elongated sample vessels are oriented in a non-parallel fashion. 1. A bucket insert for use in a centrifuge , the bucket insert comprising:an insert body, the insert body comprising a plurality of elongated receptacles for receiving elongated sample vessels, wherein the bucket insert is configured for orienting the elongated sample vessels in a tilted orientation, wherein in the tilted orientation, at least some of the elongated sample vessels are oriented in a non-parallel fashion, wherein the bucket insert is configured for orienting the elongated sample vessels in a parallel orientation, wherein in the parallel orientation the elongated sample vessels are oriented in a parallel fashion, wherein the bucket insert is at least partially flexibly deformable, and wherein the bucket insert is configured for re-orienting the elongated sample vessels from the tilted orientation into the parallel orientation and/or vice versa by deformation of the insert body.2. The bucket insert according to claim 1 , wherein claim 1 , in the tilted orientation claim 1 , the elongated sample vessels are axially oriented towards a common rotational axis.3. The bucket insert according to claim 1 , wherein the insert body comprises a plurality of body segments claim 1 , wherein each body segment comprises at least one of the elongated receptacles.4. The bucket insert according to claim 3 , wherein the body segments are tiltable about at least one tilting axis such that at least two of the body segments are tiltable with respect to each other.5. The bucket insert according to claim 3 , wherein the insert body comprises at least one connecting ...

Devices and methods for plasma separation and storage

A centrifugal cartridge or disk used for extraction of light supernatant fractions from fluid samples is described, particularly for non-homogenous fluid biological samples such as whole blood. The device may be used to collect cell-free blood plasma or a fraction of whole blood containing target cells such as leukocytes. Single or multiple channels are described, including channels with passive valves, gaskets, receiving cavities, inlet holes, capillary wicking ridges, distal cavities for cell retention, separator gel, and density medium. Centrifugal action causes whole blood in a receiving cavity to pass into one or more channels where it separates into blood cells, plasma and optionally fractions of an intermediate density. After spin, the plasma returns to the receiving cavity by way of the one or more channels for extraction through the inlet hole or other inwardly located hole. Disposable cartridges are constructed of monolithic top and bottom plates, which may be joined together by an elastomeric outer seal.