24-05-2018 дата публикации
Номер: US20180140614A1
Принадлежит:
The present invention provides a method of manufacturing foamable, corticosteroid containing compositions as well as methods for treating various skin diseases. 1. A foamable pharmaceutical composition comprising:a) a corticosteroid or a pharmaceutically acceptable salt, ester, or solvate thereof;b) an aliphatic alcohol;c) at least one foam structuring agent comprising one or more fatty alcohols, non-ionic surfactants, or combinations thereof;d) a polyol;e) a can corrosion inhibitor; ande) water; andf) a propellant, wherein the composition is void of a buffer.2. The composition of claim 1 , wherein the corticosteroid is selected from the group consisting of methylprednisolone claim 1 , hydrocortisone claim 1 , prednisolone claim 1 , clobetasone claim 1 , hydrocortisone butyrate claim 1 , flumetasone claim 1 , fluocortin claim 1 , fluperolone claim 1 , fluorometholone claim 1 , fluprednidene claim 1 , desonide claim 1 , triamcinolone claim 1 , alclometasone claim 1 , hydrocortisone buteprate claim 1 , dexamethasone claim 1 , clocortolone claim 1 , betamethasone claim 1 , fluclorolone claim 1 , desoximetasone claim 1 , fluocinolone acetonide claim 1 , fluocortolone claim 1 , diflucortolone claim 1 , fludroxycortide claim 1 , fluocinonide claim 1 , budesonide claim 1 , diflorasone claim 1 , amcinonide claim 1 , halometasone claim 1 , mometasone furoate claim 1 , methylprednisolone aceponate claim 1 , beclomethasone claim 1 , hydrocortisone aceponate claim 1 , fluticasone claim 1 , prednicarbate claim 1 , difluprednate claim 1 , halobetasol claim 1 , resocortol butyrate claim 1 , clobetasol and halcinonide.3. The composition of claim 2 , wherein the corticosteroid is halobetasol.4. The composition of claim 1 , wherein the aliphatic alcohol is methyl claim 1 , ethyl claim 1 , isopropyl or butyl alcohol claim 1 , or a combination thereof.5. The composition of claim 1 , wherein the aliphatic alcohol is ethyl alcohol.6. The composition of claim 1 , wherein the fatty alcohol ...
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