04-02-2016 дата публикации
Номер: US20160031847A1
[Problem]To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. 2. The compound or a salt thereof according to claim 1 , wherein{'sup': '1', 'sub': '1-3', 'Lis a bond or Calkylene,'}{'sup': '2', 'Lis lower alkylene optionally substituted with a substituent D1, and'}{'sup': 1', '1', '2, 'sub': 2', '2', '2, 'Ris H or lower alkyl optionally substituted with at least one substituent selected from the group consisting of (i) aryl optionally substituted with a substituent D2, (ii) an aromatic heterocyclic group optionally substituted with a substituent D2, and (iii) —COH, or Rwith the nitrogen atom bonded thereto and the HOC-Lgroup on the nitrogen atom form 1,2,3,4-tetrahydroisoquinolin-2-yl substituted with at least one —COH group,'} halogen,', '—OH,', '—O-lower alkyl,', '—SH,', '—S-lower alkyl,', '—S(O)-lower alkyl,', {'sub': '2', '—S(O)-lower alkyl,'}, '—CN,', {'sub': '2', '—NO,'}, {'sub': '2', '—NH,'}, '—NH-(lower alkyl),', {'sub': '2', '—N(lower alkyl),'}, '—C(O)-lower alkyl,', {'sub': 2', '2', '2, 'aryl substituted with at least one substituent selected from the group consisting of —O-(lower alkyl optionally substituted with at least one —COH group), halogen, —COH, and lower alkyl which is optionally substituted with at least one substituent selected from the group consisting of halogen and —COH,'}, '—C(O)—O-lower alkyl,', {'sub': '2', '—COH, or'}, 'a biological equivalent thereof,, 'the substituent D1 is'}and halogen,', '—OH,', '—O-lower alkyl,', '—SH,', '—S-lower alkyl,', '—S(O)-lower alkyl,', {'sub': '2', '—S(O)-lower alkyl,'}, '—CN,', {'sub': '2', '—NO,'}, {'sub': '2', '—NH,'}, '—NH-(lower alkyl),', {'sub': '2', '—N(lower alkyl),'}, '—C(O)-lower alkyl,', {'sub': '2', '—C(O)—NH,'}, '—C(O)—NH-(lower alkyl),', {'sub': '2', '—C(O)—N(lower alkyl),'}, '—C(O)—O-lower alkyl,', {'sub': '2', '—COH, or'}, 'a biological equivalent thereof,', {'sub': 2', '2', '2', '2', '2', '2, 'lower alkyl optionally substituted with halogen, —OH, ...
Подробнее
