Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год

Применить Всего найдено 1773. Отображено 194.
14-10-2021 дата публикации

ПОЛУЧЕНИЕ N,N-(ДИ)АЛКИЛАМИНОАЛКИЛ(МЕТ)АКРИЛАМИДА ИЛИ N,N-(ДИ)АЛКИЛАМИНОАЛКИЛ(МЕТ)АКРИЛАТА И ИХ ЧЕТВЕРТИЧНЫХ АММОНИЕВЫХ СОЛЕЙ В КАЧЕСТВЕ ФЛОКУЛИРУЮЩИХ ВСПОМОГАТЕЛЬНЫХ ВЕЩЕСТВ И ГЕЛЕОБРАЗУЮЩИХ АГЕНТОВ

Номер: RU2757390C2

FIELD: chemistry. SUBSTANCE: invention relates to a method for the preparation of N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl(meth)acrylate or their quaternary ammonium salts. The specified method includes interaction in a liquid phase of alkyl(meth)acrylate with amine or alcohol to obtain a product containing the specified N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl(meth)acrylate or their quaternary ammonium salts, wherein the concentration of oxygen in the liquid phase is <1000 ppm, and the specified N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl(meth)acrylate have the formula (I), in which R 0 is hydrogen or methyl, X is NH or O, R 2 is linear branched or cyclic alkylene radical containing 1-12 carbon atoms or aryl radical, which can also be substituted with at least one alkyl group, R 3 , R 4 are linear branched or cyclic alkyl radical containing 1-12 carbon atoms or aryl radical, which can also be substituted with at least one alkyl group. The product has the content of less than 1200 ppm of a compound of the formula (IV), in which R 0 is hydrogen or methyl, X is NH or O, R 5 in each case is linear branched or cyclic alkylene radical, aryl radical, which can also be substituted with at least one alkyl group, linear, cyclic or branched alkyl radical containing 1-12 carbon atoms. EFFECT: proposed method allows obtaining N,N-(di)alkylaminoalkyl(meth)acrylamides or N,N-(di)alkylaminoalkyl(meth)acrylates with low content of compounds of the formula (IV). 10 cl, 2 tbl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07C 213/06 C07C 219/08 C07C 231/02 C07C 233/38 C08F 220/60 (11) (13) 2 757 390 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 213/06 (2020.08); C07C 219/08 (2020.08); C07C 231/02 (2020.08); C07C 233/38 (2020.08); C08F 220/60 (2020.08) (21)(22) Заявка: 2017122606, 27.06.2017 27.06.2017 ...

Подробнее
11-10-2017 дата публикации

СОЕДИНЕНИЯ ДЛЯ НАЦЕЛЕННОЙ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА И УСИЛЕНИЯ АКТИВНОСТИ siPHK

Номер: RU2632888C2

FIELD: pharmacology.SUBSTANCE: in formula, Rand Rare independently selected from the group consistingof C-Calkyl, C-Calkenyl and oleyl group; Rand Rare independently selected from the group consisting of C-Calkyl and C-Calkanol; X is selected from the group consisting of -CH- and -S-, or absent; Y is selected from -(CH)and -S(CH), where n is 1 to 4; a=1-4; b=1-4; c=1-4 and Z is a counter ion. The invention also relates to a star-cell-specific drug carrier comprising a star-cell-specific amount of a retinoid molecule and a cationic lipid consisting of a compound of formula I.EFFECT: improved delivery of therapeutic drugs and increased activity thereof.31 cl, 16 dwg, 14 tbl, 43 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07C 237/08 C07C 323/41 C07C 333/04 A61K 9/127 A61K 47/18 (11) (13) 2 632 888 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2013158456, 08.06.2012 (24) Дата начала отсчета срока действия патента: 08.06.2012 Дата регистрации: Приоритет(ы): (30) Конвенционный приоритет: 08.06.2011 US 61/494,710; 08.06.2011 US 61/494,840 (45) Опубликовано: 11.10.2017 Бюл. № 29 (73) Патентообладатель(и): НИТТО ДЕНКО КОРПОРЕЙШН (JP) (85) Дата начала рассмотрения заявки PCT на национальной фазе: 09.01.2014 (56) Список документов, цитированных в отчете о поиске: JP 61-89286 A, 07.05.1986. JP 61- (86) Заявка PCT: US 2012/041753 (08.06.2012) 136584 A, 24.06.1986. WO 2010/061880 A1, 03.06.2010. RU 2203268 C2, 27.04.2003. 2 6 3 2 8 8 8 R U WO 2012/170952 (13.12.2012) Адрес для переписки: 105064, Москва, а/я 88, "Патентные поверенные Квашнин, Сапельников и партнеры" (54) СОЕДИНЕНИЯ ДЛЯ НАЦЕЛЕННОЙ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА И УСИЛЕНИЯ АКТИВНОСТИ siPHK (57) Реферат: Изобретение относится к соединениям звездчатым клеткам носителю для формулы I, которые могут найти применение для лекарственного средства, содержащему улучшения доставки терапевтических специфичное к ...

Подробнее
20-01-2006 дата публикации

МИНИМИЗАЦИЯ ЛЕТУЧИХ СЕРАОРГАНИЧЕСКИХ ПОБОЧНЫХ ПРОДУКТОВ ПРИ КВАТЕРНИЗАЦИИ АМИРОВ ДИМЕТИЛСУЛЬФАТОМ, ВЫПОЛНЯЕМОЙ В ПРИСУТСТВИИ ГИПОФОСФОРИСТОЙ КИСЛОТЫ

Номер: RU2005124514A
Принадлежит:

... 1. Способ минимизации запаха при кватернизации аминов диметилсульфатом, выполненной в присутствии гипофосфористой кислоты, который включает проведение указанной кватернизации в присутствии диметилсульфата, где указанный диметилсульфат содержит сернистый ангидрид в количестве меньшем, чем 20 ч./млн. 2. Способ по п.1, где указанный запах вызывают летучие сераорганические побочные продукты. 3. Способ по п.2, в котором указанный диметилсульфат содержит меньше, чем 8 ч./млн, сернистого ангидрида. 4. Способ по п.3, в котором указанный диметилсульфат содержит меньше, чем 5 ч./млн, сернистого ангидрида. 5. Способ получения сложноэфирной четвертичной аммониевой соли, имеющей улучшенный профиль запаха, который включает этерификацию алканоламина жирной кислотой, в присутствии катализатора этерификации/восстановительного отбеливающего агента, имеющего стандартный восстановительный потенциал, составляющий, по крайней мере, 0,5 В, для получения аминозамещенного сложного эфира, и последующую кватернизацию ...

Подробнее
10-09-2014 дата публикации

УМЯГЧИТЕЛЬ ДЛЯ ТКАНИ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

Номер: RU2013109294A
Принадлежит:

... 1. Способ получения умягчителя для ткани, содержащего эфиркват формулы 1:[Формула 1]в которой А и В каждый независимо представляет собой CHCHOH или CHCHOCR, иRи Rкаждый независимо выбран из группы, состоящей из линейной или разветвленной алкил-группы и алкенил-группы С-Си комбинации их групп,который содержит осуществление первой реакции переэтерификации жирную кислоту содержащего масла и третичного гидроксиламина при температуре 110-130°C в условиях давления 50 мм рт.ст. (6,5 кПа) или менее и осуществление второй реакции переэтерификации при температуре 130-160°C, которая увеличивается в тот момент, когда 40-60% масла превращается в реагент для получения сложного эфира гидроксиламина и жирной кислоты; иосуществление реакции кватернизации при взаимодействии полученного таким образом сложного эфира гидроксиламина и жирной кислоты с кватернизующим агентом в растворителе с получением эфирквата формулы 1, указанной выше.2. Способ получения по п.1, в котором реактором является замкнутый реактор ...

Подробнее
17-01-1974 дата публикации

VERFAHREN ZUR HERSTELLUNG VON 2-ALKOXY5-ALKYLSULFONYLBENZOESAEUREN

Номер: DE0002328912A1
Принадлежит:

Подробнее
08-12-2011 дата публикации

Quartäre Dialkanolaminester

Номер: DE102010029606A1
Принадлежит:

Gegenstand der vorliegenden Erfindung sind neue quartäre Ammoniumverbindungen vom Typ der Esterquats, sowie ein Verfahren zu deren Herstellung, als auch die Verwendung dieser in Formulierungen.

Подробнее
10-12-1980 дата публикации

PROCESS FOR THE PRODUCTION OF ALKYLARYL COMPOUNDS

Номер: GB0001580891A
Автор:
Принадлежит:

Подробнее
30-07-1980 дата публикации

A process for the preparation of basic esters of substituted hydroxycyclohexanecarboxylic acids

Номер: GB0002038813A
Автор: Sagramora, Giorgio
Принадлежит:

The yield of compounds having the general formula: (1) wherein R represents in the process comprising reacting a substituted hydroxycyclohexanecarboxylic acid with an aminoisopropyl chloride, is highly improved by heating the reaction mixture to 160 DEG to 240 DEG C. for at least 3 hours, and distilling under reduced pressure the resulting product. Thus the content of the undesired isomer is reduced to less than 1-1.5%.

Подробнее
28-02-2015 дата публикации

Fabric softener active composition

Номер: AP0000003143A
Принадлежит:

Подробнее
31-10-2012 дата публикации

Fabric softener active composition

Номер: AP2012006527A0
Принадлежит:

Подробнее
31-10-2012 дата публикации

Fabric softener active composition

Номер: AP0201206527A0
Принадлежит:

Подробнее
31-10-2012 дата публикации

Fabric softener active composition

Номер: AP0201206527D0
Принадлежит:

Подробнее
14-03-2019 дата публикации

Difluorinated compounds as depigmenting or lightening agents

Номер: AU2017315140A1
Принадлежит: Griffith Hack

The present invention relates to a compound having the following formula (I) as well as a method for preparing such a compound, a cosmetic or pharmaceutical composition containing such a compound, and the use thereof as a depigmenting, lightening, bleaching or whitening agent and for treating pigmentation disorders, notably by topical application on the skin.

Подробнее
02-02-2012 дата публикации

Manufacture of esters

Номер: AU2006314805B2
Принадлежит:

The invention relates to a process in which a compound RCOOR (I) is made by a transesterification reaction of an ester compound RCOOR (II) with an alcohol ROH (III) in the presence of a transesterification catalyst, wherein R is H or C alkyl or CH=CR-; R is C alkyl; R is selected from the group consisting of alkyl having at least 4 carbon atoms, cycloalkyl having at least 5 carbon atoms, aryl, aralkyl, alkaryl and amino alkyl; and R is -H or - C alkyl, wherein alcohol ROH (IV) is formed as a byproduct and in which said byproduct (IV) is removed by distillation in the presence of an entrainer, in which the entrainer is a compound that suppresses the formation of an azeotrope between compound (II) and byproduct (IV). The process can be useful in the preparation of esters such as dimethyl amino ethyl (meth) acrylate. The invention also provides a method of separating alcohols and esters. In a further form of the invention a process of preparing esters by a transesterification process is provided ...

Подробнее
23-02-2004 дата публикации

NOLOMIROLE HYDROCHLORIDE FORM I

Номер: AU2003260322A1
Принадлежит:

Подробнее
29-06-1993 дата публикации

PROCESS FOR THE PREPARATION OF BIS(AMINOPROPYL) ALIPHATIC GLYCOLS

Номер: CA0001319706C

... 173PUS03798 This invention relates to a process for the separation of acrylonitrile used in the cyanoethylation of glycols to produce a bis(cyanoethylated) aliphatic glycol from the resulting glycol which is then reduced with hydrogen to produce the corresponding bis(aminopropyl) aliphatic glycol. In this process acrylonitrile is reacted with an aliphatic glycol in stoichiometric excess and the acrylonitrile removed from the cyanoethylated glycol by reaction with aliphatic primary or secondary amine prior to effecting the hydrogenation of the cyanoethylated aliphatic glycol in the presence of the acrylonitrile-amine reaction product. The reaction product then can be separated by conventional techniques such as distillation.

Подробнее
19-04-2001 дата публикации

PROCESS OF PREPARING A HIGH-ENERGY SOFTENING AGENT

Номер: CA0002370145A1
Принадлежит:

The present invention relates to a continuous process of preparing N-alkyl- nitratoethylamines and a production plant for carrying out a continuous process of preparing such N-alkyl-nitratoethylamines.

Подробнее
23-11-2010 дата публикации

PROCESS FOR THE PREPARATION OF POLYALKYLPHENOXYAMINOALKANES

Номер: CA0002431025C
Автор: GRAY, JAMES A.
Принадлежит: CHEVRON ORONITE COMPANY LLC

A process for the preparation of polyalkylphenoxyaminoalkanes which comprises the aminoethylation of a polyalkylphenol compound in the presence of a basic catalyst with .beta.-amino alcohol or derivative thereof having the following structure: R1NH-CHR2-CH2-OH and a dialkyl carbonate having the following formula: (R3O)2CO wherein R1 and R2 are independently hydrogen or lower alkyl having 1 to about 6 carbon atoms, hydroxylalkylene, phenyl, alkaryl, or aralkyl, R3 is lower alkyl having 1 to about 6 carbon atoms, and wherein the polyalkyl group of said polyalkylphenol has an average molecular weight in the range of about 600 to 5,000. Optionally, an alcohol co-solvent having the structure R4-OH wherein R4 is an alkyl group of about 4 to 10 carbon atoms may be used.

Подробнее
06-04-1995 дата публикации

ACTIVE SUBSTANCE DELIVERY SYSTEM

Номер: CA0002171421A1
Принадлежит:

The present invention relates to compositions comprising a compound containing a nitrogen linked by an ester bond to an active substance radical having an efficient deposition of the active substance radical to a surface followed by delayed release of an active substance to the surface.

Подробнее
30-10-1998 дата публикации

PROCESS FOR PREPARING BENZOIC ACID DERIVATIVE INTERMEDIATES AND BENZOTHIOPHENE PHARMACEUTICALS

Номер: CA0002231013A1
Принадлежит:

The invention relates to novel intermediates and processes for producing benzothiophenes employing hydroxylamines.

Подробнее
18-12-1997 дата публикации

METHOD OF PREPARING QUATERNARY TRIALKANOLAMINE ESTER SALTS

Номер: CA0002256450A1
Принадлежит:

Described is a method of preparing quaternary trialkanolamine ester salts or formula (I) in which X- is the anion of an inorganic or organic acid, Ra is a C1-C4 alkyl group; Rb and Rc, independently of each other, are a C1-C3 alkylene group and Rd is a saturated and/or unsaturated aliphatic C1-C22 carboxylic acid group, m, n, p and q are whole numbers, m being 1 to 3, n being 0 to 3, p being 0 to 1, m+n+p being equal to 4 and q being 1 or, when m = 3, n = 0 and p = 1, q is 2. The method calls for a quaternary compound of formula (II), in which X-, Ra, Rb, Rc, m, n, p and q are as defined above, to be esterified, in the presence of an oxyacid of phosphorus and/or one of its alkali-metal or alkaline-earth salts as a catalyst, with a saturated and/or unsaturated aliphatic C1-C22 carboxylic acid individually or in a mixture, the water formed being removed from the reaction mixture.

Подробнее
30-11-1945 дата публикации

Verfahren zur Darstellung eines basischen Aralkyläthers.

Номер: CH0000240133A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-11-1945 дата публикации

Verfahren zur Darstellung eines basischen Aralkyläthers.

Номер: CH0000240135A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-11-1945 дата публикации

Verfahren zur Darstellung eines basischen Aralkyläthers.

Номер: CH0000240143A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269407A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269408A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269409A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269402A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269411A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269401A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
31-03-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000267634A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269406A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269405A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269410A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-06-1950 дата публикации

Verfahren zur Darstellung eines basischen Äthers.

Номер: CH0000269403A
Принадлежит: GEIGY AG J R, J. R. GEIGY AG.

Подробнее
30-04-1965 дата публикации

Verfahren zur Herstellung neuer sekundärer Amine

Номер: CH0000390943A
Принадлежит: CIBA GEIGY, CIBA AKTIENGESELLSCHAFT

Подробнее
31-10-1975 дата публикации

Номер: CH0000568284A5
Автор:

Подробнее
30-06-1971 дата публикации

Monoesterification of arylmalonic acids

Номер: CH0000509248A
Принадлежит: PFIZER, PFIZER INC.

The acid is esterified with an alcohol in the presence of thionyl chloride or bromide and a catalytic amount of HCON(Alkyl)2 or MeCON(Alkyl)2 in the ether as solvent. The products are useful for prepg. mono-ester acid chlorides for acylating 6-APA. The yield in the process is good.

Подробнее
30-06-2009 дата публикации

НОВЫЙ СПОСОБ СИНТЕЗА ЗАМЕЩЕННЫХ ГИДРОКСИМЕТИЛФЕНОЛОВ

Номер: EA200802399A1
Принадлежит:

Настоящее изобретение описывает способ получения 2-(3-диизопропиламино-1-фенилпропил)-4-(гидроксиметил)фенола или его сложных фенольных моноэфиров или их солей, включающий стадию а) реакции соединения формулы (II) со смесью инициатора Гриньяра и Mg в растворителе, b) при необходимости, снижения температуры реагента Гриньяра до уровня ниже температуры на шаге а) и реакцию полученного в результате реагента Гриньяра с избытком карбоната в растворителе с получением соединения формулы (III) где А представляет собой C1-С6-алкил, а затем реакцию соединения формулы (III) обычным способом для получения желаемого конечного продукта.

Подробнее
25-06-1998 дата публикации

METHOD OF PRODUCING N-METHYL 2 - (3.4 - DIMETHOXYPHENYL) ETHYLAMINE

Номер: EA0199700392A1
Автор:
Принадлежит:

Подробнее
25-07-1969 дата публикации

PROCESS FOR THE PRODUCTION OF DIARYLETHERS

Номер: FR0001576110A
Автор:
Принадлежит:

Подробнее
20-06-1980 дата публикации

Procédé de préparation d'esters basiques d'acides hydroxy-cyclohexane-carboxyliques substitués.

Номер: FR0002442225A
Автор: Giorgio Sagramora.
Принадлежит:

Procédé de préparation d'esters basiques d'acides hydroxy cyclohexane-carboxyliques substitués. On augmente fortement le rendement en composés répondant à la formule générale : ...

Подробнее
04-01-1980 дата публикации

METHOD FOR PREPARING COMPOSE ALKYLARYLIQUES

Номер: FR0002348909B1
Автор:
Принадлежит:

Подробнее
15-06-2012 дата публикации

METHOD OF PREPARATION OF (METH) ACRYLATES Of ALKYLAMINOALKYLE

Номер: FR0002968659A1
Принадлежит: ARKEMA FRANCE

L'invention concerne les monomères (méth)acryliques spéciaux et a trait plus particulièrement à un procédé amélioré de préparation de (méth)acrylates d'alkylaminoalkyle en présence d'un catalyseur choisi parmi les chélates de calcium avec les composés 1,3-dicarbonylés, comme l'acétylacétonate de calcium. Ce procédé est particulièrement avantageux pour la synthèse du méthacrylate de tert-butyle aminoéthyle avec une sélectivité améliorée.

Подробнее
15-06-2018 дата публикации

METHOD FOR THE PRODUCTION OF (METH-) ACRYLIC

Номер: FR0003060001A1
Принадлежит: ARKEMA FRANCE

L'invention a pour objet un procédé de fabrication en continu d'un ester (méth)acrylique par réaction de transestérification entre un (méth)acrylate d'alkyle léger en C1-C4, avec un alcool lourd en présence d'un catalyseur, caractérisé en ce que les flux alimentant le réacteur sont introduits par l'intermédiaire d'un mélangeur statique. L'utilisation d'un mélangeur statique permet d'améliorer la sélectivité de la réaction et en conséquence la productivité globale du procédé de synthèse d'esters (méth)acryliques.

Подробнее
26-06-2014 дата публикации

PROCESS FOR PRODUCING ALKYL ACRYLATE

Номер: WO2014096648A1
Принадлежит:

The invention relates to a process for continuously producing alkyl acrylate by transesterification reaction between a light alkyl acrylate and a heavy alcohol in the presence of at least one catalyst and of at least one polymerization inhibitor. The process of the invention is characterized in that the treatment of the crude reaction mixture is carried out by distillation using a single simple column producing an alkyl acrylate of high purity, while at the same time enabling the recycling of exploitable fractions.

Подробнее
06-12-2001 дата публикации

METHOD FOR THE PRODUCTION OF ESTERS OF UNSATURATED CARBOXYLIC ACIDS

Номер: WO2001092198A1
Принадлежит:

The invention relates to a method for the production of an ester of an unsaturated carboxylic acid by reaction of an ester formed from the unsaturated carboxylic acid and a C1-C4 alkanol with an alcohol R3OH in the presence of a transesterification catalyst, where R3 = a C4-C20 alkyl group, a C5-C7-cycloalkyl group, a phenyl-C1-C4 alkyl group, or a C2-C12 alkyl group, substituted by at least one NR5R5 group, or 1 to 3 hydroxy groups or C1-C4 alkoxy groups, or interrupted by one or more oxygen heteroatoms, whereby the group R5 = independently of each other, C1-C6 alkyl, or, together with the nitrogen atom, form a 5-7 membered heterocyclic ring which can optionally contain a further nitrogen or oxygen atom. At least one metal alkanoate is used as transesterification catalyst with at least one OR1 group, where R1 = a 4-(2,2,6,6-tetraalkylpiperidine-N-oxide). The invention further relates to a metal alcoholate with at least one OR1 group, where R1 = a 4-(2,2,6,6-tetraalkylpiperidine-N-oxide ...

Подробнее
22-08-2002 дата публикации

PROCESS FOR PRODUCING 1,3-BIS(3-AMINOPHENOXY)BENZENE

Номер: WO0002064544A1
Принадлежит:

A process for industrially producing in a high yield 1,3-bis(3-aminophenoxy)benzene, which is effective as, e.g., a material for polyimides having high heat resistance, which comprises reacting 1,3-difluorobenzene with an alkali metal salt of 3-aminophenol.

Подробнее
01-08-2013 дата публикации

PROCESSES FOR THE PREPARATION OF FESOTERODINE

Номер: US20130197260A1
Принадлежит: CADILA HEALTHCARE LIMITED

The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns. 1. Fesoterodine 2-chloro-mandelate.2. The fesoterodine 2-chloro-mandelate as claimed in claim 1 , which is in a crystalline form or an amorphous form.3. The fesoterodine 2-chloro-mandelate as claimed in claim 1 , wherein 2-chloro-mandelic acid is racemic(±) 2-chloro-mandelic acid claim 1 , S-(+)-2-chloro-mandelic acid claim 1 , or R-(−)-2-chloro-mandelic acid.4. The festerodine 2-chloro mandelate as claimed in claim 3 , wherein the 2-chloro-mandelic acid is S-(+)-2-chloro-mandelic acid.5. Fesoterodine 2-chloro-mandelate as claimed in claim 1 , with one or more of the following properties:i) a powder X-ray diffraction pattern having peaks at about 9.9, 12.9, 14.2, 19.2, 20.7 and 24.9±0.2 degrees 2-theta;{'figref': {'@idref': 'DRAWINGS', 'FIG. 5'}, 'ii) a powder X-ray diffraction pattern as depicted in ;'}{'figref': {'@idref': 'DRAWINGS', 'FIG. 6'}, 'iii) a DSC thermogram having an endotherm peak at about 162° C. or substantially as depicted in ; or'}{'sup': '−1', 'figref': {'@idref': 'DRAWINGS', 'FIG. 7'}, 'iv) an infrared spectrum having absorption bands at about 3346, 2985, 2970, 2939, 2873, 2603, 2368, 1755, 1620, 1492, 1388, 1328, 1224, 1190, 1120, 1087, 1062, 1031, 970, 916, 867, 819, 759, 732, 705, 607, 582. 561, 522 and 501 cmor a spectrum depicted in .'}6. A process for the preparation of fesoterodine 2-chloro-mandelate claim 1 , the process comprising obtaining a solution of fesoterodine in one or more ...

Подробнее
20-07-2017 дата публикации

MULTIFUNCTIONAL (METH)ACRYLATE MANUFACTURING METHOD

Номер: US20170204044A1
Принадлежит: TOAGOSEI CO., LTD.

[Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. 1. A multifunctional (meth)acrylate manufacturing method , wherein the following catalyst A and catalyst B are used in combination for manufacturing a multifunctional (meth)acrylate by a transesterification of a polyhydric alcohol and a monofunctional (meth)acrylate:Catalyst A: one or more kinds of compounds selected from the group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof,Catalyst B: one or more kinds of compounds selected from the group consisting of zinc-containing compounds.2. The multifunctional (meth)acrylate manufacturing method according to claim 1 , wherein the polyhydric alcohol is a polyhydric alcohol having 3 or more alcoholic hydroxyl groups.3. The multifunctional (meth)acrylate manufacturing method according to claim 1 , wherein the polyhydric alcohol is any one of trimethylolethane claim 1 , trimethylolpropane claim 1 , glycerin claim 1 , an alkylene oxide adduct of glycerin claim 1 , tris(2-hydroxyethyl)isocyanurate claim 1 , triethanolamine claim 1 , ditrimethylolethane claim 1 , ditrimethylolpropane claim 1 , diglycerin claim 1 , an alkylene oxide adduct of diglycerin claim 1 , pentaerythritol claim 1 , an alkylene oxide adduct of pentaerythritol claim 1 , xylitol claim 1 , dipentaerythritol claim 1 , an alkylene oxide adduct of dipentaerythritol claim 1 , and D-sorbitol.4. The multifunctional (meth)acrylate manufacturing method according to claim 1 , wherein the polyhydric alcohol is pentaerythritol or dipentaerythritol.5. The multifunctional (meth)acrylate manufacturing method according claim 1 , wherein the monofunctional (meth)acrylate is any one ...

Подробнее
27-05-2004 дата публикации

Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor

Номер: US20040102651A1
Автор: Alexander Zelenin

The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-1-propen-1-one with sodium borohydride and acetic acid.

Подробнее
09-10-1984 дата публикации

P-Chlorophenoxyacetic acid derivative, its method of preparation, the pharmaceutical compositions containing it and its use in medicine

Номер: US0004476319A1

A new compound derived from p-chlorophenoxyacetic acid, the p-chlorophenocetate of 1-aminoadamantine-2-ethanol of the following structural formula I: см. иллюстрацию в PDF-документе as well as its pharmaceutically acceptable salts, possessing properties for the treatment of various pathological conditions of the central nervous system. Also disclosed are its method of preparation; pharmaceutical compositions containing the said compounds; and the treatment of various pathological conditions of the central nervous system with the use of the said compositions.

Подробнее
06-04-1999 дата публикации

Preparation and uses of N-methylnitrone

Номер: US0005892117A1
Автор: Theriot; Kevin J.
Принадлежит: Albemarle Corporation

Oxidation of secondary amines with hydrogen peroxide and sodium tungstate is reported to give good yields of nitrones. However, when using dimethylamine in this manner, a considerable amount of N,N-dimethylformamide was produced as a co-product. To more selectively produce N-methylnitrone from dimethylamine, a two-step process is used which comprises (a) mixing together dimethylamine and a peroxidic compound, and subjecting the resultant mixture to reaction conditions effective to form a reaction mixture in which N,N-dimethylhydroxylamine has been formed; and (b) mixing together (i) reaction mixture from (a), (ii) a peroxidic compound, and (iii) a transition metal-containing oxidation catalyst, and subjecting the resultant mixture to reaction conditions effective to form a reaction mixture in which N-methylnitrone has been formed. Highest yields of N-methylnitrone are achieved by conducting step (b) at a pH in the range of 7 to about 12, and at a temperature in the range of about -10° to ...

Подробнее
12-05-1998 дата публикации

Surfactants based on quaternary ammonium compounds preparation processes softening bases and compositions derived

Номер: US0005750492A
Автор:
Принадлежит:

Cationic surfactant compound comprising, in the form of a quaternary ammonium salt, a product of condensation between, on the one hand a fraction of saturated or unsaturated fatty acids, or of derivatives of said acids chosen from the group comprising esters, anhydrides and acid chlorides, and on the other hand at least one tertiary amine, characterized in that, in combination: the alkyl chains of the tertiary amine together contain from 4 to 12 carbon atoms the alkyl chains of the tertiary amine together contain from 1 to 4 functions each chosen from the group comprising hydroxyl and amine functions the fatty acids fraction/tertiary amine mole ratio is between 1.85 and 1.40 the fatty acids each possess a hydrocarbon chain in which the number of carbon atoms is between 5 and 23.

Подробнее
08-08-2017 дата публикации

Functionalized choline chloride ionic liquid, preparation method thereof and use in electrochemical energy storage device

Номер: US0009728806B2

The present invention discloses a process for preparing a functionalized choline chloride ionic liquid as defined in formula (I), and thereof use in an electrochemical energy storage device, as an electrolyte solution or an additive for a lithium ion battery and a supercapacitor. The ionic liquid electrolyte material has better biocompatibility, flame retardance, high ionic conductivity, low viscosity, and wide electrochemical window. wherein R1is selected from the group consisting of: (CH2═CH—(CH2)n)—, CN(CH2)n—, or R23Si—; R2is selected from CH3—(CH2)m—, n is an integer selected from 1 to 3, m is an integer selected from 0 to 2; or one of R2is (CH3)3Si—O—. Anion A in Formula I is selected from the group consisting of: Cl−, Br−, I−, BF4−, NO3−, SO42−, CF3COO−, CF3SO3−, (CF3SO2)2N−, PF6−, BF2C2O4−, or B(C2O4)2−.

Подробнее
15-03-2016 дата публикации

Star-shaped hyperbranched polymer with triethanolamine core, carboxylate lateral group and dithiocarboxylate end group, and preparing method as well as application thereof

Номер: US0009283416B2
Принадлежит: Tongji University

A star-shaped hyperbranched polymer with a triethanolamine core, a carboxylate lateral group and a dithiocarboxylate end group has a formula of N[CH2CH2OCOCH2CH2(COOM)N(CSSM)CH2CH2N(CSSM)2]3, wherein M is Na+, NH4+ or K+. The star-shaped hyperbranched polymer has an effectively stabilization effect on heavy metals in MSWI fly ash. A method thereof for stabilizing is simple, low in dosage, cheap and without secondary pollution. Therefore, heavy metals leaching concentration in fly ash stabilized production is lower than a limit of Chinese national standard. Furthermore, acid and alkali resistance thereof is sufficient, which decreases a long-term pollution risk in natural environment.

Подробнее
28-02-2002 дата публикации

High Di(alkyl fatty ester) amines and quaternary ammonium compounds derived therefrom

Номер: US2002025915A1
Автор:
Принадлежит:

The present invention generally relates to a textile softening composition which comprises, as the softening agent, a quaternary ammonium salt which comprises a mixture of mono-, di- and tri-ester components, wherein the amount of diester quaternary is greater than about 50% by weight, and the amount of triester quaternary is less than about 25% by weight based on the total amount of quaternary ammonium salt. The invention also relates to a softening agent which comprises a high diester quaternary ammonium salt mixture comprising mono- and diester components derived for ether dialkanolamines. The invention also relates to processes for preparing said softening agents, and methods of use as a fabric softener and as a hair and skin conditioner.

Подробнее
22-10-2020 дата публикации

PROCESS FOR PREPARING DIMETHYLAMINOALKYL (METH)ACRYLATES

Номер: US20200331845A1
Принадлежит: EVONIK OPERATIONS GMBH

The present invention relates to a process for preparing dimethylaminoalkyl (meth)acrylates from alkyl (meth)acrylate and dimethylaminoalkanol. It likewise relates to the use of a catalyst system comprising a solution of a lithium alkoxide in alcohol in the preparation of a dimethylaminoalkyl (meth)acrylate. 115-. (canceled)16. A process for preparing dimethylaminoalkyl (meth)acrylate , comprising reacting a mixture comprising: (a) alkyl (meth)acrylate , (b) dimethylaminoalkanol and (c) a catalyst system comprising a solution of a lithium alkoxide in alcohol to produce said dimethylaminoalkyl (meth)acrylate , wherein the catalyst system contains no alkaline earth metal compounds.17. The process of claim 16 , wherein during the reaction claim 16 , additional amounts of (a) the alkyl (meth)acrylate claim 16 , (b) the dimethylaminoalkanol and claim 16 , optionally claim 16 , (c) the catalyst system are added to the reaction mixture and the dimethylaminoalkyl (meth)acrylate which forms is removed partly or completely from the reaction mixture.18. The process of claim 16 , wherein the dimethylaminoalkanol is selected from the group consisting of: 2-dimethylamino-1-ethanol claim 16 , 3-dimethylamino-1-propanol claim 16 , 4-dimethylamino-1-butanol claim 16 , 5-dimethylamino-1-pentanol claim 16 , 6-dimethylamino-1-hexanol claim 16 , 7-dimethylamino-1-heptanol claim 16 , and 8-dimethylamino-1-octanol.19. The process of claim 16 , wherein the alkyl (meth)acrylate is selected from the group consisting of: methyl (meth)acrylate claim 16 , ethyl(meth)acrylate claim 16 , propyl (meth)acrylate claim 16 , butyl (meth)acrylate claim 16 , pentyl (meth)acrylate claim 16 , hexyl (meth)acrylate claim 16 , heptyl (meth)acrylate claim 16 , and octyl (meth)acrylate.20. The process of claim 16 , wherein the dimethylaminoalkanol is 2-dimethylamino-1-ethanol and the alkyl (meth)acrylate is methyl methacrylate.21. The process of claim 16 , wherein the lithium alkoxide is selected from the ...

Подробнее
26-06-1996 дата публикации

Quaternary fatty-acid triethanolamine esters

Номер: EP0000718275A1
Принадлежит:

Prodn. of quaternised tri:ethanolamine fatty acid di:ester(s) Prodn. of quaternised triethanolamine fatty acid diesters(I) comprises: (a) reacting triethanolamine (II) with 1.5-2.5 equivs. of a mixt. of 70-90 wt.% fatty acid and 10-30 wt.% fatty acid ester and quaternising the prod.; or (b) reacting (II) with 1.5-2.5 equivs. of a fatty acid, reacting (II) with 1.5-2.5 equivs. of a fatty acid ester, mixing the resulting diesters in a wt. ratio of 70:30 to 90:10 and quaternising the mixt.; or (c) reacting (II) with 1.5-2.5 equivs. of a fatty acid, reacting (II) with 1.5-2.5 equivs. of a fatty acid ester, quaternising the resulting diesters and mixing the prods. in a wt. ratio of 70:30 to 90:10. Also claimed are (I) produced as above.

Подробнее
15-07-1987 дата публикации

A method for preparing bis(beta-(N,N,-dimethylamino)-ethyl)ether

Номер: EP0000106353B1
Принадлежит: TOYO SODA MANUFACTURING CO., LTD.

Подробнее
10-08-2022 дата публикации

AMINOALKYL (METH)ACRYLATE STABILISATION

Номер: EP3860971B1
Принадлежит: ARKEMA FRANCE

Подробнее
26-09-2018 дата публикации

АНИОННО-КАТИОННО-НЕИОНОГЕННОЕ ПОВЕРХНОСТНО-АКТИВНОЕ ВЕЩЕСТВО, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ

Номер: RU2668104C1

Настоящее изобретение относится к анионно-катионно-неионогенному поверхностно-активному веществу для добычи нефти. Анионно-катионно-неионогенное поверхностно-активное вещество – АКНПАВ - для добычи нефти представляет собой одно или более соединений, представленных приведенной формулой с указанным видом и сочетанием радикалов. Способ получения указанного выше АКНПАВ включает стадии взаимодействия указанных многофункциональных соединений с одним или более указанными алкиленоксидами в присутствии щелочного катализатора с получением простого эфира, взаимодействия полученного эфира с указанным кватернизирующим агентом при указанных условиях. Композиция заводняющей жидкости для добычи нефти третичным методом включает указанное выше АКНПАВ или АКНПАВ, полученное указанным выше способом, и воду, где содержание АКНПАВ составляет 0,001-19 вес. % в расчете на общий вес композиции указанной заводняющей жидкости. Способ получения композиции заводняющей жидкости для добычи нефти третичным методом включает ...

Подробнее
07-05-2019 дата публикации

Способ получения сложных эфиров таллового масла для изготовления жестких пенополиуретанов (варианты)

Номер: RU2687070C1

Изобретение относится к способу получения сложных эфиров таллового масла, которые могут найти применение для получения жёстких пенополиуретанов. По первому варианту способ получения сложных эфиров таллового масла для получения жёстких пенополиуретанов, включает этерификацию таллового масла многоатомными спиртами путём нагревания при температуре 140–150°С в течение 3 часов в присутствии катализатора на основе сульфатированного оксида циркония на силикагеле, с размерами частиц 120-200 нм, в количестве 2,5-3,5% от количества таллового масла. По второму варианту перед этерификацией многоатомными спиртами проводят термообработку путём нагревание таллового масла в присутствии катализатора на основе сульфатированного оксида циркония на силикагеле, с размерами частиц 120-200 нм, в количестве 1,5-2,0% от количества таллового масла при температуре 100–120°С в течение 3 часов , после чего проводят этерификацию многоатомными спиртами путём нагревания при температуре 140-150°С в течение 3 часов в присутствии ...

Подробнее
14-04-2017 дата публикации

СПОСОБ ОТВЕРЖДЕНИЯ СВЯЗУЮЩЕГО

Номер: RU2616295C1

Изобретение относится к улучшенному способу отверждения связующего на основе пропаргилзамещенных аминофенолов и может быть использовано для производства полимерных композиционных материалов. Способ отверждения связующего заключается в растворении соединения, выбранного из O,N,N-пропаргиламинофенола формулыгде группа N(CHC≡CH) находится в о-, м- или п-положении, и катализатора, выбранного из группы, включающей 2-этилгексаноат кобальта и трифенилфосфиновый комплекс хлорида кобальта в приемлемом растворителе. Из полученного раствора связующего и катализатора удаляют растворитель с получением раствора катализатора в связующем и осуществляют последующий нагрев упомянутого раствора катализатора в связующем до температуры отверждения с выдержкой при этой температуре в течение времени, обеспечивающего полное отверждение связующего. Нагрев до этой температуры осуществляют ступенчато с температурой на первой ступени нагревания на 10-20°С ниже температуры последующей ступени нагревания в условиях, ...

Подробнее
14-01-2021 дата публикации

Patent RU2017135548A3

Номер: RU2017135548A3
Автор: [UNK]
Принадлежит: [UNK]

ВУ"? 2017135548” АЗ Дата публикации: 14.01.2021 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017135548/04(061959) 08.06.2012 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [Х] приоритета 08.06.2012 по первоначальной заявке № 2013158456 из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 61/494,710 08.06.2011 05 2. 61/494,840 08.06.2011 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) СОЕДИНЕНИЯ ДЛЯ НАЦЕЛЕННОЙ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА И УСИЛЕНИЯ АКТИВНОСТИ яРНК Заявитель: НИТТО ДЕНКО КОРПОРЕЙШН, ]Р 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 237/08 (2006.01) С07С 333/04 (2006.01) Аб1Р 1/16 (2006.01) С07С 237/22 (2006.01) Аб1К 9/127 (2006.01) С07С 323/60 (2006.01) Аб1К 31/16 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С 237/08, С07С 237/22, С07С 323/60, С07С 333/04, Аб1К 9/127, Аб1К 31/16, Аб1Р 1/16 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины ...

Подробнее
10-05-2014 дата публикации

АКТИВНАЯ КОМПОЗИЦИЯ МЯГЧИТЕЛЯ ТКАНИ

Номер: RU2012146402A
Принадлежит:

... 1. Активная композиция мягчителя ткани, содержащаяa) не менее 50 мас.% бис-(2-гидроксипропил)-диметиламмонийметилсульфатного эфира жирной кислоты, обладающего отношением количества молей фрагментов жирной кислоты к количеству молей аминных фрагментов, равным от 1,5 до 1,99, где средняя длина цепи фрагментов жирной кислоты составляет от 16 до 18 атомов углерода и йодное число фрагментов жирной кислоты, рассчитанное для свободной жирной кислоты, равно от 0,5 до 50, иb) от 0,5 до 5 мас.% жирной кислоты.2. Активная композиция мягчителя ткани по п.1, отличающаяся тем, что отношение количества молей фрагментов жирной кислоты к количеству молей аминных фрагментов равно от 1,85 до 1,99.3. Активная композиция мягчителя ткани по п.1 или 2, отличающаяся тем, что йодное число фрагментов жирной кислоты, рассчитанное для свободной жирной кислоты, равно от 5 до 40, предпочтительно от 15 до 35.4. Активная композиция мягчителя ткани по п.1 или 2, отличающаяся тем, что она содержит от 1 до 5 мас.% и предпочтительно ...

Подробнее
20-10-2008 дата публикации

СЛОЖНЫЕ ЭФИРЫ ЖИРНЫХ КИСЛОТ И АЛКАНОЛАМИНОВ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ СМЯГЧАЮЩИХ АГЕНТОВ

Номер: RU2007113818A
Принадлежит:

... 1. Применение соединений, полученных посредством реакции этерификации алканоламина общей формулы (I) карбоновой кислотой или ее реакционным производным, общей формулы R5COOH, или дикарбоновой кислотой или ее реакционным производным, общей формулы HOOC-R6-COOH, в которых, по крайней мере, один из радикалов от R1 до R4 является -[CH2CHR7O]p-H, остальные являются H или С1-C6 алкилами, R5 является линейной или разветвленной C2-C22-алкильной или -алкенильной группой, R6 является C1-C36 -алкиленовой группой, необязательно насыщенной или ненасыщенной, или ариленовой группой, R7 является H или С1-С4-алкилом, n является числом от 1 до 20, m является числом от 1 до 5, и p является числом от 1 до 10, в качестве смягчающих или разрыхляющих агентов или наполнителей в целлюлозно-бумажной промышленности. 2. Применение по п.1, где реакционные производные карбоновых кислот представляют их сложные эфиры, их ангидриды или их хлорангидриды, и где R1-R4 представляют -[CH2CHR7O]P-H, n=1-4, m=1-3, p=1-5, R5 является ...

Подробнее
08-12-2011 дата публикации

Quartäre Dialkanolaminester

Номер: DE102010029610A1
Принадлежит:

Gegenstand der vorliegenden Erfindung sind neue quartäre Ammoniumverbindungen vom Typ der Esterquats, sowie ein Verfahren zu deren Herstellung, als auch die Verwendung dieser in Formulierungen.

Подробнее
27-12-1982 дата публикации

PROCEDURE FOR THE PRODUCTION 2 ' - DIAETHYLAMINO-1'METHYL [THYL-2-HYDROXY-2-CYCLOHEXYL-ODER -2-PHENYL-CYCLOHEXANCARBOXYLAT

Номер: AT0000369355B
Автор:
Принадлежит:

Подробнее
25-08-1993 дата публикации

VERFAHREN ZUR HERSTELLUNG VON SUCCINYLCHOLINHALOGENIDEN

Номер: AT0000396361B
Автор:
Принадлежит:

Подробнее
15-06-2010 дата публикации

DISTANCE OF SULFUR DIOXIDE ARREARS FROM DIMETHYL SULFATE

Номер: AT0000468320T
Принадлежит:

Подробнее
15-05-1982 дата публикации

PROCEDURE FOR THE PRODUCTION 2 ' - DIAETHYLAMINO-1'METHYL [THYL-2-HYDROSY-2-CYCLOHEXYL-ODER -2-PHENYL-CYCLOHEXANCARBOXYLAT

Номер: AT0000739979A
Автор:
Принадлежит:

Подробнее
01-03-2012 дата публикации

Alkoxylated alkylamines/alkyl ether amines with peaked distribution

Номер: US20120053054A1
Принадлежит: Akzo Nobel NV

The present invention generally relates to a process for preparing the alkoxylated alkylamines and/or alkyl ether amines. The process consists of three stages, and utilizes an alkali catalyst. The alkoxylated alkyl amines and alkoxylated alkyl ether amines prepared by the process possess the peaked distribution and contain less hazardous by-product.

Подробнее
05-07-2012 дата публикации

Compositions, Synthesis, and Methods of Using Cycloalkylmethylamine Derivatives

Номер: US20120172426A1
Принадлежит: Reviva Pharmaceuticals Inc

The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

Подробнее
28-03-2013 дата публикации

QUATERNARY DIALKANOLAMINE ESTERS

Номер: US20130078208A1
Принадлежит: EVONIK GOLDSCHMIDT GMBH

The invention relates to novel quaternary ammonium compounds of the esterquat type, to a method for the production thereof, and to the use thereof in formulations. 2. The quaternary dialkanolamine ester as claimed in claim 1 , wherein{'sub': 5', '11', '7', '15', '9', '19', '11', '23', '13', '27, 'acyl radicals from group (a) are selected from CHCO—, CHCO—, CHCO—, CHCO— and CHCO—,'}{'sub': 15', '29', '17', '33', '17', '31', '17', '29', '19', '37', '19', '31', '19', '29, 'acyl radicals from group (b) are selected from CHCO—, CHCO—, CHCO—, CHCO—, CHCO—, CHCO— and CHCO—,'}{'sub': 19', '39', '21', '43', '23', '47, 'acyl radicals from group (c) are selected from CHCO—, CHCO— and CHCO— and'}acyl radicals from group (d) are selected from acyl radicals of the carboxylic acids which are additionally present in technical mixtures of the carboxylic acids which determine the acyl radical from groups (a), (b) and (c).3. The quaternary dialkanolamine ester as claimed in claim 1 , wherein{'sub': 11', '23, 'acyl radicals from group (a) are selected from CHCO—,'}{'sub': 15', '29', '17', '33', '17', '31', '17', '29', '19', '37, 'acyl radicals from group (b) are selected from CHCO—, CHCO, CHCO—, CHCO— and CHCO— in a weight ratio of 3-7:68-76:5-13:1-3:0-2,'}{'sub': 19', '39', '21', '43', '23', '47, 'acyl radicals from group (c) are selected from CHCO—, CHCO—, CHCO— in a weight ratio of 4-8:85-99:0-3.'}4. A quaternary dialkanolamine ester as claimed in claim 1 , wherein the acyl radicals from groups (a) to (d) are determined via the acyl radicals of a mixture consisting oftechnical lauric acid,technical oleic acid andtechnical behenic acid.5. A quaternary dialkanolamine ester as claimed in claim 1 , wherein the numerical average of the molar ratio of the sum of acyl radicals from group (a) and group (b) to acyl radicals from group (c) is 1:0.67 to 4.6. A process for preparing quaternary dialkanolamine esters claim 1 , comprising the process steps of{'sub': 2', '2', '4', '3', '6', '4', '8 ...

Подробнее
11-04-2013 дата публикации

GOLD COMPLEXES FOR USE IN THE TREATMENT OF CANCER

Номер: US20130090472A1
Принадлежит: UNIVERSITY OF KWAZULU-NATAL

The invention provides compounds of the Formula (I), in which W is independently selected from W, W, W, W, W, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Z—Zbonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Yor Y represents a pair of substituents independently selected from H, C--Calkyl, Zor Zaryl, or Y is optionally a bridging structure that may comprise one or more C--Camide, C--Cether, or C--Cester groups, R-Rare independently selected from no substituent, a lone pair of electrons, H, halogen, C-Caryl, C- C-alkyl, amine, C--Calkylamine, C--Camide, nitro, cyano, carboxyl, C--Cester, phosphane, thiol, C--Cthioether, OR′, and suitable pairs of adjacent R groups (R-R) may optionally together form part of a Cor Caryl ring, a Zor Zring, R′ is independently selected from H, C--Calkyl, Zor Zaryl, C--Cester, poly(—CO—), amine, and C--Calkylamine, Z-Zare independently selected from C, N, P, O, and S, and X is a pharmaceutically acceptable anion, for the treatment of cancer. 2. The compound of claim 1 , in which the anion is selected from halide claim 1 , hexafluorophosphate claim 1 , nitrate claim 1 , and triflate.3. The compound of claim 1 , in which Y represents two hydrogen atoms or Y.4. The compound of claim 3 , in which Y is Yand Zand Zare N.5. The compound of claim 4 , in which Z-Zare C.6. The compound of claim 1 , in which R-Rare selected from H claim 1 , C-Calkyl claim 1 , O—C-Calkyl claim 1 , hydroxyl and halogen.7. The compound of claim 6 , in which C-Calkyl is methyl claim 6 , O—C-Calkyl is O-ethyl claim 6 , and halogen is chlorine.8. The compound of claim 1 , in which W is selected from W claim 1 , W claim 1 , WWor W.9. The compound of claim 8 , in which R-Rare selected from H claim 8 , C-Calkyl claim 8 , O—C-Calkyl and halogen.10. The compound of claim 9 , in which C-Calkyl is methyl claim 9 , O—C-Calkyl is O-ethyl and ...

Подробнее
10-04-2014 дата публикации

PROCESS FOR PREPARATION OF SUCCINYLCHOLINE CHLORIDE

Номер: US20140100385A1
Принадлежит: Sequent Scientific Limited

The present invention relates to a process for the preparation of succinylcholine chloride, a pharmaceutically active compound used as skeletal muscle relaxant which comprises condensing succinic anhydride with N,N-diemthylaminoethanol using a catalyst in presence of a solvent to form bis[2-(dimethylamino)ethyl]succinate; in situ purifying the bis[2-(dimethylamino)ethyl]succinate using a base; reacting pure bis[2-(dimethylamino)ethyl]succinate with methyl chloride gas using an alcohol; and purifying the obtained crude succinylcholine chloride using water and alcohol. 2. The process of claim 1 , wherein the catalyst in step a) is selected from the group consisting of mineral acids claim 1 , trifluoro acetic acid claim 1 , and p-toluene sulfonic acid (PTSA).3. The process of claim 1 , wherein the acid catalyst in step a) is p-toluene sulfonic acid.4. The process of claim 1 , wherein the acidic resin is an amberlite.5. The process of claim 1 , wherein the solvent in step a) is an inert organic solvent selected from the group consisting of toluene claim 1 , benzene claim 1 , and xylene.6. The process of claim 1 , wherein the solvent in step a) is toluene.7. The process of claim 1 , wherein the condensation in step a) is carried out at about 110-120° C.8. The process of claim 1 , wherein the base used in step b) is an alkali metal carbonate or alkali metal bicarbonate or an organic base.9. The process of claim 1 , wherein the base used in step b) is potassium carbonate.10. The process of claim 1 , wherein the reaction in step c) is carried out at about 55-65° C.11. The process of claim 1 , wherein step c) occurs in a solvent.12. The process of claim 11 , wherein the solvent is isopropanol.13. The process of claim 1 , the alcohol in step d) is isopropanol. This application claims the priority of Indian Patent Application No. 2938/MUM/2012, filed Oct. 8, 2012, which is incorporated herein by reference.The present invention relates to a novel process for the preparation of ...

Подробнее
11-01-2018 дата публикации

RECLAMATION OF NOBLE PRODUCTS IN A METHOD FOR PRODUCING (METH)ACRYLIC ESTER

Номер: US20180009736A1
Принадлежит:

The invention relates to a method for producing a (meth)acrylic ester with improved productivity, by transesterfication of a light alkyl (meth)acrylate with a heavy alcohol. The method of the invention includes the recycling of noble products recovered after the thermal treatment of heavy fractions generated during the synthesis, said thermal treatment being carried out in the presence of a dialkyl phthalate, the alkyl chain of which corresponds to that of the light alkyl (meth)acrylate. The invention applies to the production of N,N-dimethyaminoethyl acrylate from ethyl acrylate. 1. A process for recovering unreacted reagents and (meth)acrylic ester products from a heavy (meth)acrylic fraction generated during production of a (meth)acrylic ester by transesterification reaction of a light C-Calkyl (meth)acrylate with a heavy alcohol in the presence of a catalyst , the heavy fraction comprising at least unreacted reagents and (meth)acrylic ester products and Michael adducts resulting from addition reactions on the (meth)acrylic double bonds and also the catalyst , said process comprising heat treating said heavy fraction at a temperature sufficient to crack the Michael adducts into their constituent components , recovering unreacted reagents and (meth)acrylic ester products in the form of a distillate , and eliminating fluid final residue by means of a pump , wherein the heat treatment is carried out in the presence of at least one dialkyl phthalate , the alkyl chain of which corresponds to that of the light alkyl (meth)acrylate.2. The process as claimed in claim 1 , wherein the light alkyl (meth)acrylate is methyl acrylate and the dialkyl phthalate is dimethyl phthalate.3. The process as claimed in claim 1 , wherein the light alkyl (meth)acrylate is ethyl acrylate and the dialkyl phthalate is diethyl phthalate.4. The process as claimed in claim 1 , wherein the light alkyl (meth)acrylate is butyl acrylate and the dialkyl phthalate is dibutyl phthalate.5. The process ...

Подробнее
03-02-2022 дата публикации

Anionic-cationic-nonionic surfactant, production and use thereof

Номер: US20220033705A1

An anionic-cationic-nonionic surfactant as substantially represented by the formula (I) exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. In the formula (I), each group is as defined in the specification.

Подробнее
04-02-2016 дата публикации

ANTIMUSCARINIC COMPOUND HAVING A LOW CONTENT OF IMPURITIES

Номер: US20160031796A1
Принадлежит: DIPHARMA FRANCIS S.R.L.

Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed. 1. A process for the preparation of a substantially stable to degradation Fesoterodine fumarate , comprising:the salification of Fesoterodine base with fumaric acid in the presence of a solvent wherein the molar ratio between Fesoterodine base and fumaric acid is comprised between about 1:0.10 and about 1:0.88;the precipitation of Fesoterodine fumarate from the resulting solution;the recovery of the solid.2. Process according to wherein the Fesoterodine base to fumaric acid molar ratio is comprised between about 1:0.5 and about 1:0.85.4. Process according to wherein the molar ratio of the compound of formula (IV) to fumaric acid is comprised between about 1:0.4 and about 1:0.80.6. A substantially stable to degradation Fesoterodine fumarate as obtainable according to the process of .7. Fesoterodine fumarate according to claim 5 , having a total content of the impurities of formula (VI) claim 5 , (VII) (VIII) or (IX) equal to or lower than 0.1% claim 5 , and preferably comprised between about 0.1% and about 0.01% claim 5 , calculated as Area % by HPLC.8. A pharmaceutical composition comprising substantially stable to degradation Fesoterodine fumarate according to and a pharmaceutically acceptable carrier and/or excipient.9. A substantially stable to degradation Fesoterodine fumarate claim 5 , according to claim 5 , for use as a medicament claim 5 , in particular in a method of treatment of urinary incontinence in a mammal in need thereof. The invention relates to a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol isobutyrate (Fesoterodine) as fumarate salt, substantially stable as herein defined, that is Fesoterodine fumarate which substantially does not develop degradation impurities; and a method for the preparation of ...

Подробнее
15-02-2018 дата публикации

Y-TYPE DISCRETE POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREOF

Номер: US20180044280A1
Принадлежит:

The present invention discloses a Y-type discrete polyethylene glycol derivative and a preparation method thereof, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative, meanwhile the preparation method has simple steps, mild conditions, without need for strictly anhydrous environment or performing protection and deprotection steps. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity. 2. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein m is an integer of 2 to 10 claim 1 , and/or claim 1 , n is an integer of 2 to 10.3. The Y-type discrete polyethylene glycol derivative of claim 2 , wherein m is 2 claim 2 , 3 claim 2 , 4 or 5 claim 2 , and/or claim 2 , n is 2 claim 2 , 3 claim 2 , 4 or 5.4. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein the linking group X is —(CH)— claim 1 , —(CH)NH— or (CH)CONH—.5. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein for the linking group X claim 1 , i is 0 claim 1 , 1 claim 1 , 2 claim 1 , 3 or 4.6. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein the reactive group Y is selected from the group consisting of methoxy claim 1 , hydroxy claim 1 , amino claim 1 , mercapto claim 1 , carboxy claim 1 , ester claim 1 , aldehyde group claim 1 , acrylic or maleimide.7. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein for the discrete polyethylene glycol group E claim 1 , j is an integer of 0 to 20; and/or claim 1 ,{'sub': '2', 'for the discrete polyethylene glycol group E, k is an integer of 0 to 20.'}8. The Y-type discrete polyethylene glycol derivative of claim 7 , ...

Подробнее
29-05-2014 дата публикации

Process for making tertiary aminoalcohol compounds

Номер: US20140145108A1
Принадлежит: ANGUS CHEMIE GMBH

A process for making a tertiary aminoalcohol compound is disclosed. The process comprises using an excess amount of a carbonyl compound in a condensation step between the carbonyl compound and a nitroalkane in the presence of a catalytic amount of a tertiary aminoalcohol compound, and conducting a hydrogenation/alkylation step to produce the tertiary aminoalcohol. The tertiary aminoalcohol compound used to catalyze the condensation step is preferably the same tertiary aminoalcohol compound produced in the hydrogenation/alkylation step. The process uses fewer steps than conventional processes.

Подробнее
09-03-2017 дата публикации

POLY ALKANOLAMINE EMULSION BREAKERS

Номер: US20170066881A1
Принадлежит: Jacam Chemical Company 2013, LLC

Poly alkanolamines formed as the reaction products of secondary or tertiary alkanolamines, C8-C24 fatty acids, and shorter chain organic acids are provided, which serve as excellent petroleum/water emulsion breakers for water-in-oil emulsions and reverse oil-in-water emulsions. The polymers are preferably prepared using a reaction mixture of triethanolamine, tall oil fatty acids, and acetic acid. 2. The polymer of claim 1 , said alkanolamine being a tertiary alkanolamine.3. The polymer of claim 2 , said tertiary alkanolamine being selected from the group consisting of trimethylanolamine claim 2 , triethylanolamine claim 2 , tripropylanolamine claim 2 , and mixtures thereof.4. The polymer of claim 1 , where R has from about 12-24 carbon atoms.5. The polymer of claim 4 , where said fatty acid is tall oil fatty acid.6. The polymer of claim 1 , where said organic acid is selected from the group consisting of methanoic claim 1 , ethanoic claim 1 , propanoic claim 1 , butanoic claim 1 , pentanoic claim 1 , and hexanoic acids claim 1 , and mixtures thereof.7. The polymer of claim 6 , said organic acid being acetic acid.8. The polymer of claim 1 , said polymer having a molecular weight of from about 500-10 claim 1 ,000.9. The polymer of claim 8 , said molecular weight being from about 3000-5000.10. The polymer of claim 1 , said polymer being in aqueous dispersion and having a viscosity of from about 35-85 cps.12. The method of claim 11 , said alkanolamine being a tertiary alkanolamine.13. The method of claim 11 , said tertiary alkanolamine being selected from the group consisting of trimethylanolamine claim 11 , triethylanolamine claim 11 , tripropylanolamine claim 11 , and mixtures thereof.14. The method of claim 11 , where R has from about 12-24 carbon atoms.15. The method of claim 13 , where said fatty acid is tall oil fatty acid.16. The method of claim 11 , where said organic acid is selected from the group consisting of methanoic claim 11 , ethanoic claim 11 , ...

Подробнее
15-03-2018 дата публикации

AROMATIC DIAMINE, AN INTERMEDIATE THEREFOR, A METHOD FOR PRODUCING THE AROMATIC DIAMINE, AND A METHOD FOR PRODUCING THE INTERMEDIATE THEREFOR

Номер: US20180072655A1
Принадлежит: SEIKA CORPORATION

An asymmetric diamine suitable for preparing a soluble polyimide and a method for preparing the same, including a compound represented by the following formula (1): 2. The compound according to claim 1 , wherein A and B are both an amino group. The present invention relates to diamino-2-phthalimidodiphenyl ether, derivatives therefor and methods for preparing them. These compounds are useful as raw materials for highly functional polymers including polyimides, and various organic compounds. The present invention further relates to an intermediate for diamino-2-phthalimidodiphenyl ether, i.e., aminonitro-2-phthalimidodiphenyl ether, dinitro-2-phthalimidodiphenyl ether and derivatives from these, and methods for preparing them.Recently, polymer materials have been desired which have high heat resistance, high tenacity in extreme conditions such as in cosmic space, and easy moldability. Patent Literature 1 describes a method of attaining high heat resistance in molding without generating volatile components by heat curing while maintaining good processability wherein a polyimide oligomer is heated and capped with a capping agent such as phenylethynylphthalic anhydride, molded, heated and, then, crosslinked and cured at the phenylethynyl group. Patent Literature 2 discloses a method for improving flowability and processability of an oligomer using asymmetric tetracarboxylic anhydride in the preparation of a composite of carbon fiber and polyimide. A cardo-type diamine is used in Patent Literature 3. The asymmetric diamine disclosed in Patent Literature 4 is 2-(4-aminophenoxy)-5-aminobiphenyl.In particular, 2-(4-aminophenoxy)-5-aminobiphenyl described in Patent Literature 4 is a raw material for preparing a polymer having high heat resistance, high tenacity and easy moldability and broadens the potentiality of asymmetric polyimides (Non-Patent Literature 1). Non-Patent Literature 2 describes that many of asymmetric polyimides have a high melt flowability on account of ...

Подробнее
09-06-2022 дата публикации

Continuous Production of Active Pharmaceutical Ingredients

Номер: US20220176270A1
Автор: Sirkar Kamalesh
Принадлежит: NEW JERSEY INSTITUTE OF TECHNOLOGY

The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs. 1. A method of producing active pharmaceutical ingredients (APIs) , comprising:(a) subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor;(b) concentrating the API precursor in the reactant stream using at least one membrane;(c) carrying out a reaction in a membrane reactor;(d) separating the API precursor from the reaction stream using a separator; and(e) crystallizing the API precursor using a crystallizer to produce APIs.2. The method of claim 1 , wherein at least one of a reactor for performing step (a) claim 1 , the separator of step (d) claim 1 , or the crystallizer of step (e) is a membrane-based device.3. The method of claim 1 , comprising heating claim 1 , cooling claim 1 , and/or quenching of solutions containing active pharmaceutical ingredients using solid hollow fiber heat exchangers.4. The method of claim 3 , wherein the heat exchangers are membrane-based.5. The method of claim 1 , comprising removing impurities from organic process streams using membrane adsorbers.6. A method for solvent exchange and nanofiltration or reverse osmosis claim 1 , comprising:(a) adding a solvent to a reaction mixture; and(b) removing preexisting solvent from the reaction mixture through a membrane by organic solvent nanofiltration or organic solvent reverse osmosis.7. A method to immobilize catalysts in pores of ...

Подробнее
13-05-2021 дата публикации

CATIONIC SURFACTANTS COMPRISING AN ETHER LINK

Номер: US20210139409A1
Принадлежит:

A cationic surfactant and a method of making the cationic surfactant are described. The method comprises reacting a lipophilic bio-based material having at least one epoxy functional group and a hydrophilic organic compound having at least one cationic functional group and at least one hydroxyl functional group to form a reaction product containing a stable ether linkage connecting the lipophilic bio-based material to the organic compound. At least a portion of the cationic functional groups is neutralized or ion exchanged with an organic acid. Incorporation of the simple organic acid reduces the surfactant's aquatic toxicity and acts as a substrate to encourage co-digestion of the surfactant molecule, making the compound more biodegradable. 1. A method of making a cationic surfactant comprising:reacting a lipophilic bio-based material having at least one epoxy functional group with a hydrophilic organic compound having at least one cationic functional group and at least one hydroxyl functional group to form a reaction product containing an ether linkage connecting the lipophilic bio-based material to the organic compound.2. The method of further comprising:neutralizing the cationic functional group in the reaction product; orion exchanging the counter ion in the cationic functional group.3. The method of wherein the lipophilic bio-based material having at least one epoxy functional group comprises epoxidized soybean oil claim 1 , epoxidized canola oil claim 1 , epoxidized linseed oil claim 1 , epoxidized high oleic soybean oil claim 1 , epoxidized olive oil claim 1 , epoxidized peanut oil claim 1 , epoxidized palm oil claim 1 , epoxidized hemp oil claim 1 , epoxidized algal oil claim 1 , epoxidized marine oils epoxidized microorganism oils claim 1 , vernonia oil claim 1 , epoxidized methyl soyate claim 1 , epoxidized methyl oleate claim 1 , epoxidized methyl linolinate claim 1 , epoxidized methyl linoleate claim 1 , vernolic acid claim 1 , or combinations thereof.4 ...

Подробнее
05-05-2016 дата публикации

New Telescoping Synthesis Of 2- Methoxymethyl-P-Phenylenediamine

Номер: US20160122286A1
Принадлежит:

A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-hydroxymethylaniline. 2. The process according to claim 1 , wherein the process further comprises the step of converting 2-methoxymethyl-p-phenylenediamine (I) into a cosmetically acceptable salt.3. The process according to claim 2 , wherein the cosmetically acceptable salt is selected from chloride claim 2 , sulfate claim 2 , hydrogensulfate or malonate salt.4. The process according to claim 1 , wherein step a) is carried out in the presence of at least one nitrosation agent.5. The process according to claim 4 , wherein the nitrosation agent is selected from the group consisting of sodium nitrite claim 4 , potassium nitrite claim 4 , dinitrogen pentoxide claim 4 , nitrosylsulfuric acid and mixtures thereof.6. The process according to claim 1 , wherein step a) is carried out in the presence of at least one radical scavenger.7. The process according to claim 1 , wherein step a) or b) is carried out in the presence of at least one mineral or organic acid.8. The process according to claim 7 , wherein the mineral or organic acid is selected from the group consisting of hydrogen chloride claim 7 , trifluoroacetic acid claim 7 , sulfuric acid claim 7 , sulfurous acid claim 7 , carbonic acid claim 7 , nitric acid claim 7 , acetic acid claim 7 , propionic acid claim 7 , phosphoric acid and mixtures thereof.9. The process according to claim 7 , wherein the mineral or organic acid is selected from the group consisting of hydrogen chloride claim 7 , sulfuric acid claim 7 , sulfurous acid claim 7 , acetic acid and mixtures thereof.10. The process according to claim 1 , ...

Подробнее
23-04-2020 дата публикации

ACETYLSALICYLIC ACID DERIVATIVE CRYSTAL, ITS PREPARATION METHOD AND USE

Номер: US20200123098A1
Автор: Zhang Jing
Принадлежит:

A disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°. 2. The method of claim 1 , wherein the indication which can be treated by acetylsalicylic acid is selected from cold and fever claim 1 , headache claim 1 , neuralgia claim 1 , muscle pain claim 1 , dysmenorrhea claim 1 , rheumatism claim 1 , rheumatoid arthritis claim 1 , gout claim 1 , cancer claim 1 , diabetes claim 1 , diabetic complications claim 1 , cardiovascular and cerebrovascular diseases claim 1 , prevention of stroke claim 1 , prevention of ischemic heart disease claim 1 , prevention of transient cerebral ischemia claim 1 , prevention of myocardial embolism claim 1 , and reduction of the incidence and mortality of arrhythmia.3. A method for preparing the 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride crystal claim 1 , wherein the method comprises the steps of:(1) mixing a crude 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride raw material with anhydrous acetonitrile, and completely dissolving the raw materials to obtain a solution where the final mass-volume ratio of the crude 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride raw material to the anhydrous acetonitrile is 1: 4-1:10 w/v; and(2) cooling the solution to 0-30° C. to precipitate the 2-(diethylamino) ethyl 2-acetoxybenzoate hydrochloride crystal having a chemical structure as represented by formula I, wherein the X-ray powder diffraction (XRPD) pattern of the crystal having characteristic peaks at the following 2θ angles: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.4. The method of claim 3 , wherein heating to refluxing anhydrous acetonitrile is required in the dissolution process.5. ( ...

Подробнее
15-09-2022 дата публикации

Synthesis method of hydroxybenzylamine

Номер: US20220289664A1
Автор: Changping Xu, Yanrong JIA

The present invention relates to a synthesis method of hydroxybenzylamine, belonging to the technical field of organic synthesis. The principle of the method is a demethylation reaction of methoxybenzylamine in the presence of hydrobromic acid. The present invention has the characteristics that methoxybenzylamine and hydrobromic acid are distilled at reflux to remove redundant water to improve a reaction temperature and increase the concentration of hydrobromic acid in a reaction mixture, thereby enhancing the demethylation of hydrobromic acid on methoxybenzylamine and then shortening a reaction time and increasing a conversion rate; when generation of a methyl bromide gas is not observed, distillation is continued, excess hydrobromic acid is recycled to further improve the reaction temperature and increase the conversion rate and meanwhile reduce the consumption of raw material hydrobromic acid and decrease the processing capacity of the subsequent steps and the consumption of raw material sodium hydroxide.

Подробнее
25-06-2015 дата публикации

The novel reference markers for fesoterodine fumarate

Номер: US20150175526A2
Принадлежит: Alembic Pharmaceuticals Ltd

The present invention relates to the new impurities of Fesoterodine, Fesoterodine symmetric dimer impurity and asymmetric dimer impurity, process for preparing and isolating thereof. The invention also deals with analytical standards and analytical methods used for the control of the production process and final quality of Fesoterodine.

Подробнее
23-06-2016 дата публикации

PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS AT LOW TEMPERATURES

Номер: US20160176803A1
Принадлежит: BASF SE

A process for the preparation of the ether of formula I 2: The process of claim 1 , wherein Ris hydrogen or an alkyl group with 1 to 4 C atoms claim 1 , Ris hydrogen claim 1 , Ris an alkyl group with 1 to 4 C atoms and X is a bond or an alkylene group with 1 to 10 carbon atoms.3: The process of claim 1 , wherein Ris a methyl group claim 1 , Ris hydrogen claim 1 , Ris a methyl group and X is a bond.4: The process of claim 1 , wherein the compound of formula II is a pure (R) or (S) enantiomer.5: The process of claim 1 , wherein in a) an imine group is formed by reacting the primary amino group with a carbonyl compound as the protection agent.6: The process of claim 1 , wherein the deprotonating agent in b) is an alkali or earth alkali alcoholate.7: The process of claim 1 , wherein the alkylation agent in c) is selected from the group consisting of alkyl chloride claim 1 , dialkyl sulfate claim 1 , and dialkyl carbonate.8: The process of claim 1 , wherein b) and c) are performed at a temperature from 0 to 80° C.9: The process of claim 1 , wherein b) and c) are performed in the presence of a solvent.10: The process of claim 1 , wherein a) to d) are performed in the same solvent without separation of intermediate products. The present invention relates to a process for the preparation of the ether of formula Ifrom an amino alcohol of formula IIwhere Rand Rindependently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, Ris an alkyl group with 1 to 10 carbon atoms and X is a bond or a hydrocarbon group with 1 to 10 carbon atoms comprising a) protecting the primary amino group in formula II with a protecting agent b) deprotonating the protected amino alcohol obtained in step a) with a deprotonating agent c) alkylation of the anion obtained in step b) with an alkylation agent to give the corresponding ether and finally d) removal of the protecting group getting back the primary amino group and giving the ether of formula I, wherein process step b) is ...

Подробнее
13-06-2019 дата публикации

SYSTEMS AND METHODS FOR PRODUCING A CHEMICAL PRODUCT

Номер: US20190176122A1
Принадлежит:

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product. 1. A system for producing a chemical product , the system comprising:a chemical product production unit comprising a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow; anda droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.2. The system according to claim 1 , further comprising a controller.3. The system according to claim 2 , wherein the system comprises one or more sensors.4. The system according to claim 3 , wherein the controller is configured to receive data from the sensors that allow the controller to monitor a process occurring in one or more of the microfluidic modules.5. The system according to claim 4 , wherein the controller is configured to adjust one or more parameters within the one or more of the microfluidic modules based on the received data.6. The system according to claim 2 , wherein the chemical product is a pharmaceutical drug and the controller comprises a program that determines an optimal drug ...

Подробнее
09-07-2015 дата публикации

METHOD FOR MANUFACTURING TERTIARY AMINO GROUP-CONTAINING LIPID

Номер: US20150191416A1
Принадлежит: NOF CORPORATION

In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from a cis form to a trans form is suppressed. 2. The method according to claim 1 , wherein the saturated hydrocarbon solvent is hexane or methylcyclohexane.36-. (canceled)7. The method according to claim 1 , wherein Ris a linoleyl group.8. The method according to claim 2 , wherein Ris a linoleyl group.13. The method according to claim 1 , wherein X is a methane sulfonate group (—OSOCH).14. The method according to claim 2 , wherein X is a methane sulfonate group (—OSOCH).15. The method according to claim 7 , wherein X is a methane sulfonate group (—OSOCH).16. The method according to claim 8 , wherein X is a methane sulfonate group (—OSOCH).17. The method according to claim 1 , wherein the alkali catalyst is potassium hydroxide.18. The method according to claim 2 , wherein the alkali catalyst is potassium hydroxide.19. The method according to claim 7 , wherein the alkali catalyst is potassium hydroxide.20. The method according to claim 8 , wherein the alkali catalyst is potassium hydroxide. The present invention relates to a method for manufacturing a tertiary amino group-containing lipid.In recent years, gene therapy is a medical treatment which can be expected to rehabilitate and normalize, at a gene level, irregularities causing various diseases. However, the gene is very unstable. For example, in the case where the gene is administered as-is, the gene undergoes decomposition due to nuclease and the like in vivo. Therefore, selection of a vector used for gene therapy is very important.Virus vectors used in the past are effective vectors exhibiting a high degree of gene transfer efficiency. However, cases in which clinical trials linked to death have also been reported, so that there is anxiety for the safety. Consequently, development of nonviral vectors with high safety and high gene introduction efficiency has ...

Подробнее
07-07-2016 дата публикации

PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS

Номер: US20160194272A1
Принадлежит: BASF SE

A process for the preparation of the ether of formula I 2: The process according to claim 1 , wherein{'sub': '1', 'Ris hydrogen or an alkyl group with 1 to 4 C atoms,'}{'sub': '2', 'Ris hydrogen,'}{'sub': '3', 'Ris an alkyl group with 1 to 4 C atoms, and'}X is a bond or an alkylene group with 1 to 10 carbon atoms.3: The process according to claim 1 , wherein{'sub': '1', 'Ris a methyl group,'}{'sub': '2', 'Ris hydrogen,'}{'sub': '3', 'Ris a methyl group, and'}X is a bond.4: The process according to claim 1 , wherein the compound of formula II is a pure (R) or (S) enantiomer.5: The process according to claim 1 , wherein the metal used as deprotonating agent is an alkali or earth alkali metal.6: The process according to claim 1 , wherein the metal used as deprotonating agent is sodium.7: The process according to claim 1 , wherein step a) is performed at a temperature of at least the melting temperature of the metal used as deprotonating agent.8: The process according to claim 1 , wherein the alkylation agent is selected from alkyl chloride claim 1 , dialkyl sulfate or dialkyl carbonate.9: The process according to claim 1 , wherein process steps a) and b) are performed in presence of a solvent.10: The process according to claim 1 , wherein process steps a) and b) are performed in presence of a solvent of formula IV{'br': None, 'sub': a', '2', 'n', 'b, 'R—O—(CH—O—)R'}wherein{'sub': a', 'b, 'Rand Rare a C1- to C6 alkyl group, and'}n is an integral number from 1 to 4. The present invention relates a process for the preparation of the ether of formula Iwhere R1 and R2 independently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, R3 is an alkyl group with 1 to 10 carbon atoms and X is a bond or a hydrocarbon group with 1 to 10 carbon atoms comprisingEthers of formula I are chemical intermediates which are, for example, used for the synthesis of pharmaceuticals, plant protecting agents as herbicides, insecticides or fungicides.Compounds of formula I may ...

Подробнее
07-07-2016 дата публикации

PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS WITH METAL ALCOHOLATES

Номер: US20160194273A1
Принадлежит: BASF SE

Process for the etherification of amino alcohols with metal alcoholates 2. A process according to claim 1 , wherein the deprotonating agent in step a) is used in less than equimolar amounts compared to the amino alcohol and the alkylation agent in step b) is used in less than equimolar amounts compared to the anion of formula III.3. A process according to claim 1 , wherein Ris hydrogen or an alkyl group with 1 to 4 C atoms claim 1 , Ris hydrogen claim 1 , Ris an alkyl group with 1 to 4 C atoms andX is a bond or an alkylene group with 1 to 10 carbon atoms.4. A process according to claim 1 , wherein Ris a methyl group claim 1 , Ris hydrogen claim 1 , Ris a methyl group and X is a bond.5. A process according to claim 1 , wherein the compound of formula II is a pure (R) or (S) enantiomer.6. A process according to claim 1 , wherein the metal alcoholate used as deprotonating agent is an alkali or earth alkali metal alcoholate.7. A process according to claim 1 , wherein the metal alcoholate used as deprotonating agent is sodium methylate.8. A process according to claim 1 , wherein the alkylation agent is selected from alkyl chloride claim 1 , dialkyl sulfate or dialkyl carbonate.9. A process according to claim 1 , wherein process steps a) and b) are performed in presence of a solvent.10. A process according to claim 1 , wherein process steps a) and b) are performed in presence of an aromatic solvent. The present invention relates to a process for the preparation of the ether of formula Iwhere Rand Rindependently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, Ris an alkyl group with 1 to 10 carbon atoms and X is a bond or a hydrocarbon group with 1 to 10 carbon atoms comprising a) deprotonating the amino alcohol of formula IIwhere R, Rand X have the meaning abovewith a metal alcoholat as deprotonating agent to give the anion of formula IIIwhere R, Rand X have the meaning aboveandb) alkylation of the anion obtained in step a) with an alkylation agent ...

Подробнее
07-07-2016 дата публикации

BIS(PERFLUOROETHER CARBOXYLIC ACID ALKYL)AMINO ESTER AND METHOD FOR PRODUCING THE SAME

Номер: US20160194275A1
Автор: KOKIN Keisuke
Принадлежит:

A bis(perfluoroether carboxylic acid alkyl)amino ester represented by the general formula: {CFO[CF(CF)CFO]CF(CF)COO(CH)}NR, wherein R is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group; preferably an alkyl group having 1 to 6 carbon atoms or an aryl group; n is an integer of 1 to 3; a is an integer of 0 to 20, preferably an integer of 1 to 6; and b is an integer of 1 to 12, preferably an integer of 1 to 4. The bis(perfluoroether carboxylic acid alkyl)amino ester having an amino group at the end of the ester group is produced by reacting a perfluoroether carboxylic acid fluoride compound of the formula: CFO[CF(CF)CFO]CF(CF)COF and a bis(hydroxyalkyl)amine compound of the formula: HO(CH)NR(CH)OH at a molar ratio of 2:1 in the presence of an alkali metal fluoride. 1: A bis(perfluoroether carboxylic acid alkyl)amino ester represented by the general formula:{'br': None, 'sub': n', '2n+1', '3', '2', 'a', '3', '2', 'b', '2, '{CF[CF(CF)CFO]CF(CF)COO(CH)}NR\u2003\u2003[I]'}wherein R is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or a phenyl group; n is an integer of 1 to 3; a is an integer of 0 to 20; and b is an integer of 1 to 12.2: A method for producing the bis(perfluoroether carboxylic acid alkyl)amino ester according to claim 1 , the method comprising reacting a perfluoroether carboxylic acid fluoride compound represented by the general formula:{'br': None, 'sub': n', '2n+1', '3', '2', 'a', '3, 'CFO[CF(CF)CFO]CF(CF)COF\u2003\u2003[II]'} {'br': None, 'sub': 2', 'b', '2', 'b, 'HO(CH)NR(CH)OH\u2003\u2003[III]'}, 'wherein n is an integer of 1 to 3, and a is an integer of 0 to 20; and a bis(hydroxyalkyl)amine compound represented by the general formulawherein R is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or a phenyl group; and b is an integer of 1 to 12; in the presence of an alkali metal fluoride.3: The method for producing the bis(perfluoroether carboxylic acid alkyl)amino ester according ...

Подробнее
03-08-2017 дата публикации

TRANSPARENT TEXTILE CARE AGENT

Номер: US20170218304A1
Принадлежит:

The present disclosure relates to textile care agents and to optically clear and transparent fabric softener formulations which also have a viscous consistency, containing a combination of special ester quats with nonionic emulsifiers and cationic thickeners, to the use of said textile care agents and fabric softener formulations. The present disclosure also relates to a method for washing textiles using said textile care agent and fabric softener formulations. The present disclosure relates to methods for producing the special ester quats, to the thus resulting ester quats and to the use thereof. 2. The liquid composition according to claim 1 , wherein:(i) the ratio of (c) to (b) in the liquid composition amounts to at least about 0.5:1 and/or(ii) the amount of (b) in the composition amounts to about 0.1-30% by weight, and/or(iii) the amount of (c) in the composition is about 0.1 to about 50% by weight, and(iv) the liquid composition comprises enzyme mixture with an amount of 0.01-5.0% by weight, based on the total weight of the liquid composition.3. The liquid composition according to claim 1 , wherein(a) the composition has at least one second nonionic emulsifier, wherein the HLB value of an emulsified mixture of the at least one first and at least one second nonionic emulsifier amounts to at least about 12.0 and/or(b) the at least one nonionic emulsifier (c) is selected from the group consisting of addition products of about 15 to about 60 mol ethylene oxide onto castor oil, hydrogenated castor or mixtures thereof.4. The liquid composition according to claim 1 , wherein the composition further comprises at least one thickener.5. The liquid composition according to claim 4 , wherein the at least one thickener is chosen from at least one nonionic thickener selected from the group consisting of hydroxyethyl cellulose (HEC) claim 4 , hydroxypropyl cellulose (HPC) claim 4 , hydroxypropylmethyl cellulose (HPMC) and methyl cellulose (MC) claim 4 , guar claim 4 , guar ...

Подробнее
08-10-2015 дата публикации

Star-shaped hyperbranched polymer with triethanolamine core, carboxylate lateral group and dithiocarboxylate end group, and preparing method as well as application thereof

Номер: US20150283417A1
Принадлежит:

A star-shaped hyperbranched polymer with a triethanolamine core, a carboxylate lateral group and a dithiocarboxylate end group has a formula of N[CHCHOCOCHCH(COOM)N(CSSM)CHCHN(CSSM)], wherein M is Na, NHor K. The star-shaped hyperbranched polymer has an effectively stabilization effect on heavy metals in MSWI fly ash. A method thereof for stabilizing is simple, low in dosage, cheap and without secondary pollution. Therefore, heavy metals leaching concentration in fly ash stabilized production is lower than a limit of Chinese national standard. Furthermore, acid and alkali resistance thereof is sufficient, which decreases a long-term pollution risk in natural environment. 3. The method claim 2 , as recited in claim 2 , wherein a mole ratio of the TEA claim 2 , the MA claim 2 , and the alkali is 1:(3.0-3.1):(3.0-3.1); a mole ration of the TEA/MA-3COOM claim 2 , the EDA claim 2 , and the alkali is 1:(4.0-6.0):(4.0-6.0); a mole ratio of the TME-3COOM claim 2 , the carbon disulfide claim 2 , and the alkali is 1:(11.25-13.50):(11.25-13.50).4. The method claim 2 , as recited in claim 2 , wherein the alcohol is methanol claim 2 , ethanol claim 2 , propanol or butanol; the alkali liquid is a water solution of ammonia claim 2 , sodium hydroxide or potassium hydroxide.5. A method for stabilizing incinerated fly ash of waste claim 1 , comprising applying the star-shaped hyperbranched polymer as recited in .6. The method claim 5 , as recited in claim 5 , specifically comprising steps of:preparing a water solution of TME-3COOM-9CSSM as a stabilizer, then dissolving the stabilizer in water and adding to the incinerated fly ash, wherein a dosage thereof is 0.5-5% of a fly ash weight; keeping stirring for 15-30 min, then drying with natural ventilation for obtaining a stabilized product of the incinerated fly ash. The present invention claims priority under 35 U.S.C. 119(a-d) to CN 201410137960.2, filed Apr. 8, 2014.1. Field of InventionThe present invention relates to a technical ...

Подробнее
29-09-2016 дата публикации

Fabric Softener Compositions

Номер: US20160281033A1
Принадлежит: Stepan Co

A fabric conditioning active composition comprising an esterquat mixture of quaternized mono-, di-, and tri-esters of alkanolamine in which the tri-esterquat content of the quaternized esterquat mixture is greater than 25% by weight of the esterquat mixture, and the combined di-esterquat and tri-esterquat content in the esterquat mixture is greater than 78% by weight of the esterquat mixture. Additionally, the free fatty acid content of the composition is greater than 1% by weight based on the weight of the esterquat mixture. The fabric conditioning active composition provides high viscosity when dispersed into water at low concentrations of 0.5% to 12%, without the need for additional polymeric thickeners or other thickening additives.

Подробнее
28-09-2017 дата публикации

TRANSESTERIFICATION REACTION BY MEANS OF IRON CATALYST

Номер: US20170275241A1

Provided is a catalyst for transesterification reactions, which contains an iron salen complex. Also provided is a method for producing an ester compound, which is characterized by carrying out a transesterification reaction between a starting material ester and a starting material alcohol with use of the catalyst. 113.-. (canceled)14. A catalyst for transesterification reaction comprising an iron-salen complex.15. The catalyst according to claim 14 , capable of performing a transesterification reaction in an alcohol-selective manner.17. The catalyst according to claim 14 , wherein the iron-salen complex has a tert-butyl group at a 4-position or a 5-position.18. The catalyst according to claim 14 , wherein the solvent for the iron-salen complex is toluene.19. The catalyst according to claim 14 , having enantioselectivity.20. The catalyst according to claim 14 , for producing a tert-butyl ester.21. A method for producing an ester compound claim 14 , wherein a transesterification reaction between a starting material ester and a starting material alcohol is performed by using the catalyst according to .22. The method according to claim 21 , wherein the starting material alcohol is ethanol claim 21 , tert-butyl alcohol claim 21 , cyclohexanol claim 21 , benzyl alcohol claim 21 , adamantanol or an amino alcohol.23. The method according to or claim 21 , wherein the starting material ester is an active ester or a methyl ester.25. The method according to claim 21 , wherein the ester compound is a tert-butyl ester.26. A method for using the iron-salen complex claim 21 , wherein the iron-salen complex is used as a catalyst when the transesterification reaction between the starting material ester and the starting material alcohol is performed. The present invention relates to an iron catalyst for the transesterification reaction.Esters and amides synthesized by using alcohols and amines are important functional groups frequently found in natural products and organic synthetic ...

Подробнее
15-10-2015 дата публикации

Method for Preparation of Bis (2-dialkyaminoethyl) Ether

Номер: US20150291506A1
Принадлежит:

A bis (2-dialkylaminoethyl) ether synthesizing method is disclosed, which includes steps of: 1) synthesizing: wherein N,N-dialkylethanolamine, N,N-dialkylamine and ethyne are mixed at a mole ratio of 4:3:1-2:1:1 as a raw material; and the raw material, catalyst and solvent are added in a high-pressure clave for reaction in a sealed condition; a weight of catalyst accounts for 2.0%-10.5% of the total weight of the raw material; a reaction temperature is 50-120° C. and the reaction time is 3-7 hours; the clave is then opened after reaction and a filtrate is collected by filtering the reaction mixture; and 2) separating: wherein the filtrate obtained in the step 1) is rectified to obtain the bis (2-dialkylaminoethyl) ether as a product. The synthetic method of the bis (2-dialkylaminoethyl) ether in the present invention has many characteristics, such as simple process, high atomic economy, etc. 1. A bis (2-dialkylaminoethyl) ether synthesizing method comprising steps of:1) synthesizing:wherein N,N-dialkylethanolamine, N,N-dialkylamine and ethyne are mixed at a mole ratio of 4:3:1-2:1:1 as a raw material;the raw material, catalyst and solvent are added in a high-pressure clave for reaction in a sealed condition; a weight of catalyst accounts for 2.0%-10.5% of the total weight of the raw material; a reaction temperature is 50-120° C. and the reaction time is 3-7 hours; and the clave is opened after reaction, the catalyst is removed by filtering and a filtrate is collected; and2) separating:wherein the filtrate obtained in the step 1 is rectified with bis (2-dialkylaminoethyl) ether as product.2. The bis (2-dialkylaminoethyl) ether synthesizing method claim 1 , as recited in claim 1 , whereinin the step 2):solvent and excessive, the N,N-dialkylethanolamine and the N,N-dialkylamine, are collected as the raw material.3. The bis (2-dialkylaminoethyl) ether synthesizing method claim 1 , as recited in claim 1 , wherein:when the N,N-dialkylethanolamine is N,N- ...

Подробнее
09-12-2021 дата публикации

Aminoalkyl (meth)acrylate stabilisation

Номер: US20210380523A1
Принадлежит: Arkema France SA

The present invention relates to the use of a stabilizing composition comprising at least one N-oxyl compound and at least one polymerization inhibitor other than an N-oxyl compound, for inhibiting transesterification catalyst degradation in a process for the synthesis of aminoalkyl (meth)acrylates. Preferably, the transesterification catalyst is a titanium organometallic compound and the stabilising composition comprises at least one N-oxyl derivative and at least one polymerization inhibitor chosen from phenolic compounds and phenothiazine compounds in a weight ratio of between 1 and 10, preferably between 4 and 10, limits inclusive.

Подробнее
25-12-2014 дата публикации

NOVEL REFERENCE MARKERS FOR FESOTERODINE FUMARATE

Номер: US20140374284A1
Принадлежит:

The present invention relates to the new impurities of Fesoterodine, Fesoterodine symmetric dimer impurity and asymmetric dimer impurity, process for preparing and isolating thereof. The invention also deals with analytical standards and analytical methods used for the control of the production process and final quality of Fesoterodine. 122.-. (canceled)24. An isolated specific impurity of Fesoterodine Fumarate claim 23 , compound of formula II as claimed in claim 23 , characterized by chemical purity of more than 50% for use in setting the analytic methods designed tor quality control of Fesoterodine Fumarate.25. Fesoterodine Fumarate having a content of compound of formula II as claimed in claim 23 , less than 0.3% by mole.26. A pharmaceutical composition comprising Fesoterodine or a pharmaceutically acceptable salt thereof claim 23 , and an amount of a compound of formula (II) as claimed in .28. A vacuum sealed pack comprising Fesoterodine Fumarate which is free of compound of formula (II) as claimed in claim 23 , wherein the Fesoterodine Fumarate is packaged in a moisture and oxygen impermeable package.29. A vacuum sealed pack according to claim 28 , wherein the pack comprises three layers:a. an Innermost layer comprises a (LDPE) low density polyethylene bag or (HM, HDPE; high molecular high-density polyethylene which is vacuum sealed and sealed using heat induction;b. a Middle layer that is a special plastic bag of (HM, HDPE) high molecular high-density polyethylene or Triple Laminate Sunlight Barrier (TLSB) bag comprising a moisture absorber and nitrogen gas purged and sealed using heat induction;3330. A pharmaceutical composition comprising Fesoterodine or a pharmaceutically acceptable salt thereof claim 28 , and an amount of a compound of formula (III) as claimed in claim .3530. A vacuum sealed pack comprising Fesoterodine Fumarate which is free of compound of formula (II) as claimed in claim claim 28 , wherein the Fesoterodine Fumarate is packaged in ...

Подробнее
22-10-2015 дата публикации

FUNCTIONALIZED CHOLINE CHLORIDE IONIC LIQUID, PREPARATION METHOD THEREOF AND USE IN ELECTROCHEMICAL ENERGY STORAGE DEVICE

Номер: US20150303511A1
Принадлежит:

The present invention discloses a process for preparing a functionalized choline chloride ionic liquid as defined in formula (I), and thereof use in an electrochemical energy storage device, as an electrolyte solution or an additive for a lithium ion battery and a supercapacitor. The ionic liquid electrolyte material has better biocompatibility, flame retardance, high ionic conductivity, low viscosity, and wide electrochemical window. 2. The functionalized choline chloride ionic liquid according to claim 1 , wherein anion A is selected from the group consisting of: Cl claim 1 , Br claim 1 , I claim 1 , BF claim 1 , NO claim 1 , SO claim 1 , CFCOO claim 1 , CFSO claim 1 , CFSO)N claim 1 , PF claim 1 , BFCO claim 1 , or B(CO).3. A process for preparing the functionalized choline chloride ionic liquid according to claim 1 , wherein the process comprises the steps of: under a condition of cooling in ice bath claim 1 , reacting choline chloride with an equi-molar amount of sodium hydroxide in an acetonitrile as solvent at room temperature for 20 minutes claim 1 , and adding drop-wise 1.1 times molar amount of halogenated alkane thereto claim 1 , followed by reacting under reflux for 8 hours; or reacting choline chloride with an equi-molar amount of organosilicon reagent under reflux for 16 hours; removing solid by filtering after completion of the reaction claim 1 , removing solvent by rotary evaporation claim 1 , and subsequently using dichloromethane and diethyl ether as solvents for recrystallization to obtain the functionalized choline chloride ionic liquid; dissolving the functionalized choline chloride ionic liquid and an equi-molar amount of alkali metal or alkaline earth metal salt in water or other solvents for anion exchange claim 1 , stirring the reaction for 4 to 6 hours claim 1 , followed by extracting the product after the ion exchange by using the dichloromethane as a solvent claim 1 , removing the solvent claim 1 , and drying to yield the target ion ...

Подробнее
10-09-2020 дата публикации

HALOGENATED HETEROALKENYL- AND HETEROALKYL-FUNCTIONALIZED ORGANIC COMPOUNDS AND METHODS FOR PREPARING SUCH COMPOUNDS

Номер: US20200283351A1
Принадлежит:

A method for synthesizing halogenated organic compounds, such as halogenated alkenyl group-containing and halogenated alkyl group-containing compounds having a heteroatom (e.g., O,N.S) coupled to a carbon atom of a halogenated alkenyl or halogenated alkyl group, involves reacting a halogenated olefin such as a chloro-substituted trifluoropropenyl compound with an active hydrogen-containing organic compound such as an alcohol (e.g., an aliphatic monoalcohol, aliphatic polyalcohol, or a phenolic compound), a primary amine, a secondary amine or a thiol. 1. A method of making a halogenated organic compound , comprising reacting an active hydrogen-containing organic compound selected from the group consisting of alcohols , primary amines , secondary amines and thiols with a halogenated olefin containing a carbon-carbon double bond , wherein at least one carbon of the carbon-carbon double bond is substituted with at least one substituent selected from the group consisting of halogens and halogenated alkyl groups , to produce the halogenated organic compound.2. The method of claim 1 , wherein the halogenated olefin contains one or more fluorine atoms.3. The method of claim 1 , wherein the halogenated organic compound is a halogenated heteroalkenyl-functionalized organic compound.4. The method of claim 1 , wherein the halogenated organic compound is a halogenated heteroalkyl-functionalized organic compound.5. The method of claim 1 , wherein the halogenated olefin has a fluorinated alkyl group substituted on one carbon of the carbon-carbon double bond.6. The method of claim 1 , wherein the halogenated olefin has a perfluorinated alkyl group substituted on one carbon of the carbon-carbon double bond.7. The method of claim 1 , wherein the halogenated olefin has a structure in accordance with formula (1):{'br': None, 'sup': 1', '2', '3', '4, 'CXX═CXX\u2003\u2003(1)'}{'sup': 1', '2', '3', '4', '1', '2', '3', '4, 'wherein X, X, Xand Xare independently selected from the group ...

Подробнее
25-10-2018 дата публикации

ACETYLSALICYLIC ACID DERIVATIVE CRYSTAL, ITS PREPARATION METHOD AND USE

Номер: US20180305296A1
Автор: Zhang Jing
Принадлежит:

Disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°. 2. The crystal of claim 1 , wherein the X-ray powder diffraction (XRPD) pattern of the crystal further having a characteristic peak at the following 2θ angle: 10.8°±0.2°.3. The crystal of claim 1 , wherein the X-ray powder diffraction (XRPD) pattern of the crystal further having characteristic peaks at the following 2θ angles: 22.8°±0.2° claim 1 , 30.4°±0.2° claim 1 , 19.2°±0.2° claim 1 , 17.6°±0.2° claim 1 , 10.6°±0.2° claim 1 , 23.0°±0.2° claim 1 , 35.7°±0.2° claim 1 , 27.9°±0.2° claim 1 , 18.2°±0.2° claim 1 , 24.8°±0.2° claim 1 , 22.1°±0.2°.4. The crystal of claim 1 , wherein the infrared absorption spectrum of the crystal having absorption peaks at 2988.0 cm claim 1 , 2974.6 cm claim 1 , 2953.7 cm claim 1 , 2889.1 cm claim 1 , 1725.9 cm claim 1 , 1759.1 cm claim 1 , 1605.6 cm claim 1 , 1576.1 cm claim 1 , 1484.0 cm claim 1 , 1448.2 cm claim 1 , 1389.9 cm claim 1 , 1068.7 cm claim 1 , 1087.1 cm claim 1 , 757.0 cm claim 1 , and in a range of 2487.3 cmto 2563.4 cm.6. The crystal of claim 5 , wherein the crystal further comprises the following characteristics claim 5 , as determined by X-ray single crystal diffraction:a crystallographic space group: Pbca;{'sup': 3', '3, 'a unit lattice volume: V=3311.4 ű1.0 Å;'}{'sup': '3', 'a crystal size: 0.211×0.176×0.112 mm;'}{'sup': '3', 'a crystal density: 1.267 mg/m;'}a number of asymmetrical units in lattice: 8; anda number of electrons in a unit cell: F(0000)=1344.7. A method for preparing the 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride crystal of claim 1 , wherein the method comprises the steps of:(1) mixing a crude 2-(diethylamino)ethyl 2-acetoxybenzoate ...

Подробнее
02-11-2017 дата публикации

ANIONIC-CATIONIC-NONIONIC SURFACTANT,PRODUCTION AND USE THEREOF

Номер: US20170313928A1
Принадлежит:

This invention relates to an anionic-cationic-nonionic surfactant as substantially represented by the formula (I), production and use thereof in tertiary oil recovery. The anionic-cationic-nonionic surfactant of this invention exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. 4. The anionic-cationic-nonionic surfactant according to claim 1 , wherein at least a part of the group X and the group (M) presents in the form of (M)X and independently from the anionic-cationic-nonionic surfactant claim 1 , preferably claim 1 , throughout the molecular structure of the anionic-cationic-nonionic surfactant claim 1 , assuming that the total number of the group X is e1 claim 1 , the total number of the group N is e2 claim 1 , the total number of the group A is e3 claim 1 , the total number of the group (M) is e4 claim 1 , if e2=e3 claim 1 , then 0≦e1≦e2 claim 1 , 0≦e4≦e3; or claim 1 , if e2>e3 claim 1 , then 0 Подробнее

31-10-2019 дата публикации

Anionic-cationic-nonionic surfactant, production and use thereof

Номер: US20190330516A1

This invention relates to an anionic-cationic-nonionic surfactant as substantially represented by the formula (I), production and use thereof in tertiary oil recovery. The anionic-cationic-nonionic surfactant of this invention exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. In the formula (I), each group is as defined in the specification.

Подробнее
19-11-2020 дата публикации

ADDITIVE FOR INCREASING EARLY ACTIVITY INDEX OF NICKEL SLAG AND PREPARATION METHOD THEREOF

Номер: US20200361822A1
Принадлежит: BEIJING UNIVERSITY OF TECHNOLOGY

An additive for increasing an early activity index of nickel slag and a preparation method thereof, belonging to the field of additive technologies, are provided. The preparation method includes: successively adding maleic anhydride and triethanolamine to a reactor; setting the heating temperature to 50° C. for reaction, where a large amount of heat is released during the reaction; when the reaction temperature decreases to 60° C. after heat is released in the reaction, allowing triethanolamine maleate to react with a solution of bromine in carbon tetrachloride; adding water to the mixture, where the weight percentage content of the added water is 60%; separating and removing carbon tetrachloride from water; and conducting uniform stirring to obtain the additive. A molar ratio of the maleic anhydride, the triethanolamine, and bromine is (0.2-1):1:(0.2-1), and a molar ratio of the maleic anhydride to the bromine is 1:1. 1. A preparation method of an additive for increasing an early activity index of nickel slag , comprising the following steps: successively adding maleic anhydride and triethanolamine to a reactor; setting the heating temperature to 50° C. for reaction , wherein a large amount of heat is released during the reaction; when the reaction temperature decreases to 60° C. after heat is released in the reaction , allowing triethanolamine maleate to react with a solution of bromine in carbon tetrachloride; adding water to the mixture , wherein the weight percentage content of the added water is 60%; separating and removing carbon tetrachloride from water; and conducting uniform stirring to obtain the additive , wherein a molar ratio of the maleic anhydride , the triethanolamine , and bromine is (0.2-1):1:(0.2-1) , and a molar ratio of the maleic anhydride to the bromine is 1:1.2. The preparation method according to claim 1 , wherein the molar ratio of the maleic anhydride claim 1 , the triethanolamine claim 1 , and the bromine is 0.8:1:0.8.3. An additive ...

Подробнее
05-01-2012 дата публикации

New process for the synthesis of tapentadol and intermediates thereof

Номер: WO2012001571A1
Принадлежит: Archimica Srl

The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. A further object of the present invention is constituted by the tapentadol free base in solid form, obtainable by means of the process of the invention. Still another object of the invention is represented by the crystalline forms I and II of the tapentadol free base. A further object of the present invention is the mixture of the crystalline forms I and II of the tapentadol free base.

Подробнее
10-12-2013 дата публикации

Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives

Номер: US8604244B2
Принадлежит: Reviva Pharmaceuticals Inc

The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

Подробнее
19-06-1997 дата публикации

METHOD FOR PRODUCING POLYOXYALKYLENAMINE

Номер: DE69310728D1
Принадлежит: CHRYSO CHILLY MAZARIN FR SA, Chryso SAS

Подробнее
07-06-2007 дата публикации

거울상 이성체적으로 순수한 아토목세틴 및 토목세틴만델레이트

Номер: KR20070057703A

본 발명은 거울상 이성체적으로 순수한 (R)-(-)-토목세틴 (S)-(+)-만델레이트 및 아토목세틴 HCl을 제공한다. 본 발명은 라세미체 5 토목세틴으로부터 제조한 거울상 이성체적으로 순수한 (R)-(-)-토목세틴 (S)-(+)-만델레이트를 추가로 제공한다. 본 발명은 또한 (R)-(-)-토목세틴 (S)-(+)-만델레이트로부터 제조한 거울상 이성체적으로 순수한 아토목세틴 HCl를 제공한다.

Подробнее
05-04-2017 дата публикации

Method for producing tertiary amino group-containing lipid

Номер: JP6108197B2
Принадлежит: NOF Corp

Подробнее
18-11-2020 дата публикации

A preparing method of diethylamino hydroxybenzoyl hexylbenzoate

Номер: KR102179649B1
Автор: 백현우, 윤종배, 최은화
Принадлежит: (주)에이에스텍

본 발명은 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법에 관한 것으로서, 구체적으로는 제조 공정이 용이하고 상업적 대량생산이 가능한 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법 및 이에 의하여 제조된 디에틸아미노하이드록시벤조일헥실벤조에이트 결정성 입자에 관한 것이다. 본 발명에 의하면 자외선 차단효과가 우수한 디에틸아미노하이드록시벤조일헥실벤조에이트 결정성 입자를 안정적이며 높은 수율로 얻을 수 있다. The present invention relates to a method for preparing diethylaminohydroxybenzoylhexylbenzoate, specifically, a method for preparing diethylaminohydroxybenzoylhexylbenzoate, which is easy to manufacture and can be mass-produced commercially, and the diethylaminohydroxybenzoylhexylbenzoate prepared thereby. It relates to ethylaminohydroxybenzoylhexylbenzoate crystalline particles. According to the present invention, diethylaminohydroxybenzoylhexylbenzoate crystalline particles having excellent UV blocking effect can be obtained in a stable and high yield.

Подробнее
04-05-2016 дата публикации

制造含有叔氨基的脂质的方法

Номер: CN104428280B
Принадлежит: NOF Corp

在分子中具有至少一个夹在相邻的两个顺式形式的双键之间的亚甲基的阳离子脂质的生产中,从顺式形式向反式形式的异构化受到抑制。使由下式(I)所表示的化合物:R 1 -X…(I)(式中,R 1 表示在分子中具有至少一个夹在相邻的两个顺式形式的双键之间的亚甲基并具有8至24的碳数的烃基,X表示释放基团)与(B)在分子中具有叔氨基和羟基各至少一个的化合物,在具有5至10的碳数的饱和烃类溶剂中,在碱催化剂存在下进行反应。

Подробнее
03-02-2022 дата публикации

A preparing method of diethylamino hydroxybenzoyl hexylbenzoate

Номер: KR102357197B1
Автор: 백현우, 윤종배, 최은화
Принадлежит: (주)에이에스텍

본 발명은 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법에 관한 것으로서, 구체적으로는 제조 공정이 용이하고 상업적 대량생산이 가능한 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법 및 이에 의하여 제조된 디에틸아미노하이드록시벤조일헥실벤조에이트 결정성 입자에 관한 것이다. 본 발명에 의하면 자외선 차단효과가 우수한 디에틸아미노하이드록시벤조일헥실벤조에이트 결정성 입자를 안정적이며 높은 수율로 얻을 수 있다. The present invention relates to a method for preparing diethylaminohydroxybenzoylhexylbenzoate, and specifically, to a method for preparing diethylaminohydroxybenzoylhexylbenzoate, which is easy to manufacture and commercially mass-produced, and diethylaminohydroxybenzoylhexylbenzoate prepared by the method Ethylaminohydroxybenzoylhexylbenzoate relates to crystalline particles. According to the present invention, diethylaminohydroxybenzoylhexylbenzoate crystalline particles having excellent UV blocking effect can be obtained in a stable and high yield.

Подробнее
18-03-2015 дата публикации

制造含有叔氨基的脂质的方法

Номер: CN104428280A
Принадлежит: NOF Corp

在分子中具有至少一个夹在相邻的两个顺式形式的双键之间的亚甲基的阳离子脂质的生产中,从顺式形式向反式形式的异构化受到抑制。使由下式(I)所表示的化合物:R 1 -X…(I)(式中,R 1 表示在分子中具有至少一个夹在相邻的两个顺式形式的双键之间的亚甲基并具有8至24的碳数的烃基,X表示释放基团)与(B)在分子中具有叔氨基和羟基各至少一个的化合物,在具有5至10的碳数的饱和烃类溶剂中,在碱催化剂存在下进行反应。

Подробнее
07-04-2022 дата публикации

COMPOUNDS FOR TARGETED DRUG DELIVERY AND ENHANCING siRNA ACTIVITY

Номер: RU2769872C2

FIELD: pharmaceutics. SUBSTANCE: invention relates to a compound consisting of the structure (retinoid) m -linker-(retinoid) n , which can be used to deliver therapeutic agents. In the structure (retinoid) m -linker-(retinoid) n m and n are independently 1, 2 or 3, the retinoid is selected from the group, consisting of vitamin A, retinoic acid, tretinoin, adapalene, 4-hydroxy(phenyl)retinamide (4-HPR), retinyl palmitate, retinal, saturated retinoic acid and saturated demethylated retinoic acid, and the linker is selected from the group consisting of polyethylene glycol (PEG), bis-amido-PEG, tris-amido-PEG, tetra-amido-PEG, Lys-bis-amido-PEG-Lys, Lys-tris-amido-PEG-Lys , Lys-tetra-amido-PEG-Lys, Lys-PEG-Lys, PEG2000, PEG1250, PEG1000, PEG750, PEG550 and PEG-Glu. Invention also relates to specific compounds and a carrier for a drug for treating fibrous disease or cancer, comprising a retinoid molecule, consisting of a structure (retinoid) m -linker-(retinoid) n , and a liposomal composition containing a compound of formula I. In formula I R 1 and R 2 are independently selected from a group, consisting of C 12 -C 18 alkyl, C 12 -C 18 alkenyl and oleyl groups; R 3 and R 4 are independently selected from the group consisting of C 1 -C 6 alkyl and C 2 -C 6 alkanol; X is selected from the group consisting of -CH 2 - and -S-, or is absent; Y is selected from -(CH 2 ) n and -S (CH 2 ) n , n=1–4; a=1–4; b=1–4; c=1–4; Z is a counterion. EFFECT: disclosed are compounds for targeted drug delivery and enhancing siRNA activity. 15 cl, 16 dwg, 14 tbl, 43 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) (19) RU (11) (13) 2 769 872 C2 (51) МПК C07C 237/08 (2006.01) C07C 237/22 (2006.01) C07C 323/60 (2006.01) C07C 333/04 (2006.01) A61K 9/127 (2006.01) A61K 31/16 (2006.01) A61P 1/16 (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 237/08 (2021.01); C07C 237/22 (2021.01); C07C 323/60 (2021.01); C07C 333/04 (2021.01); A61K 9/1271 (2021.01); A61K 31/ ...

Подробнее
02-02-2018 дата публикации

A kind of glucose amide type gemini cationic surfactant and its synthetic method

Номер: CN107652203A
Автор: 李鸿, 甘昌胜, 蔡坤良
Принадлежит: Hefei University of Technology

本发明公开了一种葡萄糖酰胺型双子阳离子表面活性剂及其合成方法,包括长链环氧季铵盐的合成、烷基二胺与环氧丙基长链季铵盐反应生成双长链烷基双子季铵盐和长链双季铵盐与葡萄糖酸内酯反应生成葡萄糖酰胺双子阳离子表面活性剂三个步骤,是一种新型的葡萄糖酰胺型双子阳离子表面活性剂,在日用化工、农业、食品、纺织以及生物医药等领域有着广泛的应用空间。此外,醛糖酸内酯与合适的烷基胺进行胺酯反应制备烷基醛糖酰胺是一个选择性反应,无需对糖分子中的羟基进行繁琐、复杂的保护,操作简单,适于工业化生产。

Подробнее
05-01-1995 дата публикации

Process for preparing phenethanol ethers

Номер: WO1995000467A1
Принадлежит: Hoechst Celanese Corporation

Substituted phenethanol ethers are prepared by the etherification of corresponding substituted phenethyl alcohols with an aliphatic primary alcohol. The etherification is carried out by reacting a substituted phenethyl alcohol with an aliphatic primary alcohol in the presence of an acid catalyst.

Подробнее
29-10-2013 дата публикации

Fabric softener active composition

Номер: US8569224B2
Принадлежит: EVONIK DEGUSSA GmbH

A fabric softener active composition, comprising at least 50% by weight of a bis-(2-hydroxypropyl)-dimethylammonium methylsulphate fatty acid ester having a molar ratio of fatty acid moieties to amine moieties of from 1.5 to 1.99, wherein the average chain length of the fatty acid moieties is from 16 to 18 carbon atoms and the iodine value of the fatty acid moieties, calculated for the free fatty acid, is from 0.5 to 50, and from 0.5 to 5% by weight fatty acid provides high softening performance and good storage stability in aqueous dispersion and can be handled and processed in a liquid state without addition of a flammable solvent.

Подробнее
11-11-2014 дата публикации

Fabric softening composition

Номер: US8883712B2
Принадлежит: EVONIK DEGUSSA GmbH

A fabric softening composition which comprises as component A a tertiary or quaternary ammonium salt of formulae (I) or (II): R 1 R 2 R 3 N + CH 2 CHR 4 OC(═O)R 5 X −   (I) R 1 R 2 R 3 N + (CH 2 ) 3 NHR(═O)R 5 X −   (II) in which R 1 is hydrogen, methyl or ethyl, R 2 and R 3 , independently of one another, are C 1-4 alkyl or C 2-4 hydroxyalkyl, R 4 is hydrogen or methyl, R 5 is a linear C 15-21 alkyl or alkenyl radical and X − is a monovalent anion, and as component B a nonionic softener with only one long-chain hydrocarbon radical bonded to a polar radical having at least one free hydroxy group, where fatty alcohol alkoxylate or fatty acid alkoxylate are excluded as component B, exhibits a good softening effect and forms storage-stable dispersions if the molar ratio of component A to component B is in the range from 2:1 to 1:3, the difference between the average chain length of the long-chain hydrocarbon radicals of components A and B is at most 2 carbon atoms and the hydrocarbon radicals of components A and B have on average in each case at most 0.5 double bonds per hydrocarbon radical. Such a composition can be produced by reacting a fatty acid, a C 2-6 diol or C 3-9 polyol, and a tertiary alkanolamine or a diamine having a tertiary and primary amino group in a suitable molar ratio with the removal of water and subsequent alkylation or protonation.

Подробнее
18-02-2003 дата публикации

Quaternary fatty acid triethanolamine ester salts and their use as fabric softeners

Номер: US6521589B2
Принадлежит: Procter and Gamble Co

The present invention relates to biodegradable softener compounds of the formula (1): [(R) 4-m —N( + )—[(CH 2 ) n —Y—R 1 ] m ]X( − ) with an acid value of no more than 6.5. A process for making said compound is also provided. The softener can be incorporated into softener compositions to form solid and liquid compositions, including liquid dispersions and clear compositions.

Подробнее
27-11-2012 дата публикации

Capped structured organic film compositions

Номер: US8318892B2
Принадлежит: Xerox Corp

A capped structured organic film comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.

Подробнее
08-08-2017 дата публикации

New process for the preparation of tapentadol and intermediates thereof

Номер: KR101766503B1
Принадлежит: 유티칼스 에스피에이

본 발명은 (2R,3R)-O,O'-다이벤조일타르타르 키랄 산을 사용하는 하기 반응식 2에 따라 라세미 혼합물(V)을 정량적으로 분해시켜 (S)-3-(다이메틸아미노)-2-메틸-1-(3-니트로페닐)-프로판-1-온(VII)의 입체 이성질체(V, VI, VII)를 수득함을 포함하는, 타펜타돌의 신규한 제조 방법에 관한 것이다. 본 발명은 또한 타펜타돌의 신규한 제조 방법에서 일부 중간체 화합물에 관한 것이다: 반응식 2 The present invention quantitatively decomposes the racemic mixture (V) according to the following scheme 2 using (2R, 3R) -O, O'- dibenzoyl tartaric chiral acid to give (S) -3- (dimethylamino) (V, VI, VII) of 2-methyl-1- (3-nitrophenyl) -propan-1-one (VII). The present invention also relates to some intermediate compounds in a novel process for preparing &lt; RTI ID = 0.0 &gt; Scheme 2

Подробнее
21-08-2017 дата публикации

The production of n,n-dialkylaminoethyl (meth)acrylates

Номер: KR101770001B1
Принадлежит: 날코 컴퍼니

Method and apparatus for preparing N, N-dialkylaminoalkyl acrylate in a continuous ester exchange reaction. The reaction comprises adding an alkyl acrylate such as methacrylate or ethacrylate to the reboiler mechanism and efficiently removing the alcohol co-product. Because the reaction is continuous, the alkyl acrylate can be added as needed to increase the product, reduce the output, or to fine tune the reaction kinetics. The azeotropic additive is used to form volatile azeotropic mixtures which contain both alcohol and azeotropic additives and which are easily removed from the reboiler mechanism. The method reduces the amount of required azeotropic additive per unit of alkyl acrylate used and eliminates the need to purify the final product from azeotropic contaminant contamination of the resulting N, N-dialkylaminoalkyl acrylate product.

Подробнее
30-01-2014 дата публикации

Compounds and organic electronic devices

Номер: WO2014015935A2
Принадлежит: Merck Patent GmBH

The present invention concerns particular fluorenes, the use of the compound in an electronic device, and an electronic device containing at least one of these compounds. The present invention further concerns a method for producing the compound and a formulation and composition containing one or more of the compounds.

Подробнее
12-10-2016 дата публикации

Connections and Organic Electronic Devices

Номер: DE202013012401U1
Автор: [UNK]
Принадлежит: Merck Patent GmBH

Verbindung der allgemeinen Formel (6)Formel (6) wobei für die verwendeten Symbole und Indices gilt: R1 ist, bei jedem Auftreten gleich oder verschieden, D, F, Cl, Br, I, C(=O)R4, CN, Si(R4)3, NO2, P(=O)(R4)2, S(=O)R4, S(=O)2R4, eine geradkettige Alkyl-, Alkoxy- oder Thioalkylgruppe mit 1 bis 20 C-Atomen oder eine verzweigte oder cyclische Alkyl-, Alkoxy- oder Thioalkylgruppe mit 3 bis 20 C-Atomen oder eine Alkenyl- oder Alkinylgruppe mit 2 bis 20 C-Atomen, wobei die oben genannten Gruppen jeweils mit einem oder mehreren Resten R4 substituiert sein können und wobei eine oder mehrere CH2-Gruppen in den oben genannten Gruppen durch -R4C=CR4-, -C≡C-, Si(R4)2, C=O, C=S, C=NR4, -C(=O)O-, -C(=O)NR4-, P(=O)(R4), -O-, -S-, SO oder SO2 ersetzt sein können und wobei ein oder mehrere H-Atome in den oben genannten Gruppen durch D, F, Cl, Br, I, CN oder NO2 ersetzt sein können, oder ein aromatisches oder heteroaromatisches Ringsystem mit 6 bis 30 aromatischen Ringatomen, das jeweils durch einen oder mehrere Reste R4 substituiert sein kann, oder eine Aryloxygruppe mit 5 bis 60 aromatischen Ringatomen, die mit einem oder mehreren Resten R4 substituiert sein kann, oder einer Aralkylgruppe mit 5 bis 60 aromatischen Ringatomen, die jeweils mit einem oder mehreren Resten R4 substituiert sein kann, wobei die beiden Reste R1 miteinander verknüpft sein können und einen Ring bilden können, so dass eine Spiroverbindung in Position 9 des Fluorens entsteht, wobei Spirobifluorene ausgeschlossen sind; R2, R3 sind bei jedem Auftreten gleich oder verschieden, bevorzugt gleich, H, D, F, Cl, Br, I, C(=O)R4, CN, Si(R4)3, NO2, P(=O)(R4)2, S(=O)R4, S(=O)2R4, N(R4)2, eine geradkettige Alkyl-, Alkoxy- oder Thioalkylgruppe mit 1 bis 20 C-Atomen oder eine verzweigte oder cyclische Alkyl-, Alkoxy- oder Thioalkylgruppe mit 3 bis 20 C-Atomen oder eine Alkenyl- oder Alkinylgruppe mit 2 bis 20 C-Atomen, wobei die oben genannten Gruppen jeweils mit einem oder mehreren Resten R4 substituiert sein können und ...

Подробнее
09-01-2019 дата публикации

Connections and organic electronic devices

Номер: EP3424907A2
Принадлежит: Merck Patent GmBH

Die vorliegende Erfindung betrifft bestimmte Fluorene, die Verwendung der Verbindung in einer elektronischen Vorrichtung, sowie eine elektronische Vorrichtung enthaltend wenigstens eine dieser Verbindungen. Weiterhin betrifft die vorliegende Erfindung ein Verfahren zur Herstellung der Verbindung sowie eine Formulierung und Zusammensetzung enthaltend eine oder mehrere der Verbindungen. The present invention relates to certain fluorenes, the use of the compound in an electronic device, and an electronic device containing at least one of these compounds. Furthermore, the present invention relates to a process for the preparation of the compound and to a formulation and composition comprising one or more of the compounds.

Подробнее
20-07-2018 дата публикации

Smooth opening master batch of one kind and preparation method thereof

Номер: CN108299719A
Автор: 高嘉芃
Принадлежит: Guangzhou Grasses Mstar Technology Ltd

本发明涉及高分子材料技术领域,具体公开了一种爽滑开口母粒及其制备方法。所述的爽滑开口母粒包含如下重量份的原料组分:PE树脂80~100份;爽滑剂30~50份;开口剂30~50份;马来酸酐接枝相容剂20~30份;抗氧化剂1~3份。该母粒是一种全新组成的爽滑开口母粒,所述的爽滑开口母粒加入了全新制备得到的有机开口剂,其开口性以及润滑性能好。

Подробнее
27-11-2018 дата публикации

Diamine compounds, and polyimide compounds and moldings using the same

Номер: KR101922417B1

본 발명은 유기용제에 대한 높은 용해성 및 높은 용융 성형성을 갖는 폴리이미드 화합물을 합성할 수 있는 신규 디아민 화합물을 제공하는 것으로서, 본 발명에 의한 디아민 화합물은, 하기 일반식 (1)로 표시되는 것을 특징으로 한다. (상기 식 중, R 1 ∼R 8 이, 각각 독립하여, 수소, 불소, 치환 또는 무치환의 알킬기 및 치환 또는 무치환의 방향족기로 이루어지는 군으로부터 선택되는 것이지만, R 1 ∼R 8 중 적어도 1개가 치환 또는 무치환의 방향족기이다.) The present invention provides a novel diamine compound capable of synthesizing a polyimide compound having high solubility in an organic solvent and high melt moldability, The diamine compound according to the present invention is characterized by being represented by the following general formula (1). (Wherein, R 1 to R 8 are each independently selected from the group consisting of hydrogen, fluorine, substituted or unsubstituted alkyl groups and substituted or unsubstituted aromatic groups, provided that at least one of R 1 to R 8 is substituted or unsubstituted Aromatic group.)

Подробнее
19-07-2019 дата публикации

The synthesis and application of laccol analog

Номер: CN110028467A
Принадлежит: Huazhong Normal University

本发明公开了漆酚类似物的合成与应用,属于高分子功能材料领域。本发明为利用Mannich反应和植物油进行漆酚类似物合成的方法,包括合成酰胺类和酯类漆酚类似物:(1)以二级二元胺对植物油进行胺解,再与邻苯二酚和甲醛进行Mannich反应,得到酰胺类漆酚类似物;(2)以邻苯二酚、甲醛和含羟基二级胺为原料,通过Mannich反应得到含羟基的3‑位取代邻苯二酚中间体,再与来自植物油的羧酸经过酯化反应,得到酯类漆酚类似物。本发明合成方法具有原料廉价易得、合成路线短、原子经济效率高、产物易于分离纯化等优点。所合成的漆酚类似物通过紫外光照射下固化成膜,涂膜具有优异的附着力、柔韧性、热稳定性和抗腐蚀性能。

Подробнее
18-03-2019 дата публикации

Process for recovering noble products in a process for producing dialkylaminoalkyl (meth)acrylates

Номер: KR101959591B1
Принадлежит: 아르끄마 프랑스

본 발명은 알킬 (메트)아크릴레이트와 아미노 알코올의 에스테르교환 반응에 의한 디알킬아미노알킬 (메트)아크릴레이트, 특히 N,N-디메틸아미노에틸 아크릴레이트의 제조에 관한 것이고, 이의 주제는 보다 특히 상기 제조 동안 발생되는 중질 부산물을 회수하고 디알킬아미노알킬 (메트)아크릴레이트 정제 단위 상에서 특정 생성물의 재활용을 가능하게 하는 방법이다. The present invention relates to the preparation of dialkylaminoalkyl (meth) acrylates, in particular N, N-dimethylaminoethyl acrylate, by transesterification of alkyl (meth) acrylates with aminoalcohols, To recover heavy byproducts generated during manufacturing and to enable the recycling of certain products over dialkylaminoalkyl (meth) acrylate purification units.

Подробнее
09-07-2021 дата публикации

Preparation method of meclofenoxate hydrochloride

Номер: CN109400489B
Автор: 尚伟, 谭珍友, 黎万

本发明公开了一种盐酸甲氯芬酯的制备方法,包括以下步骤:(A)将对氯苯氧乙酸与氯化亚砜发生酰氯化反应,得到对氯苯氧乙酰氯;(B)将步骤(A)得到的对氯苯氧乙酰氯和二甲氨基乙醇经缩合反应得到甲氯芬酯游离碱;(C)将步骤(B)得到的游离碱成盐酸盐,保温过滤得到盐酸甲氯芬酯。本发明原料易得,反应温度低,操作方便,粗品纯度高,质量稳定,本发明提供了一种更易于操作、更环保、更经济的盐酸甲氯芬酯的合成途径。

Подробнее
30-07-1985 дата публикации

Method of producing 1-isopropylamino-3-/4-(2-methoxyethyl)-phenoxy/-2-propanol

Номер: SU1170968A3
Принадлежит: Аб Хэссле (Фирма)

A process for the preparation of metoprolol or 1isopropylamino-3-(4-(2-methoxy)ethylphenoxy)-2-propanol wherein 3-(4-(2-methoxy)ethyl)phenoxy-1,2-propanediol is reacted with thionyl chloride in dichlormethane in the presence of triethylamine to form 4-(4-((2-methoxy-ethyl)phenoxy)methyl)-1,3,2-dioxathiolane-2-oxide < IMG > which is then reacted with isopropylamine in acetonitrile.

Подробнее
14-09-2020 дата публикации

Fluorenes and electronic devices containing them

Номер: KR102155492B1
Принадлежит: 메르크 파텐트 게엠베하

본 발명은 특정 플루오렌에 관한 것이며, 전자 소자에서 상기 화합물의 용도 및 이들 화합물을 하나 이상 포함하는 전자 소자에 관한 것이다. 또한, 본 발명은 상기 화합물의 제조 방법 및 상기 화합물을 하나 이상 포함하는 제형 및 조성물에 관한 것이다. The present invention relates to certain fluorenes, to the use of such compounds in electronic devices and to electronic devices comprising one or more of these compounds. In addition, the present invention relates to a method for preparing the compound and to formulations and compositions comprising at least one of the compounds.

Подробнее
06-11-2013 дата публикации

Softener composition

Номер: CN102245828B
Принадлежит: Kao Corp

本发明涉及柔软剂组合物。本发明的柔软剂组合物含有用通式(I)表示的特定的双(聚烷氧基烷醇)型季铵盐。 (式中,R 1 和R 2 相同或不同,分别是碳原子数为11~23的烃基,R 3 和R 4 相同或不同,分别是具有或不具有羟基的碳原子数为1~4的烃基,k和l相同或不同,分别是5~10的整数,X - 是阴离子)。

Подробнее
20-03-2003 дата публикации

Synthesis of alkylaminoalkyl (meth)acrylate by transesterification

Номер: WO2003022796A1
Принадлежит: Röhm Gbmh & Co. Kg

The invention relates to a method for transesterifying methyl methacrylate involving catalysis, particularly zirconium acetylacetonate catalysis. The obtained esters of formula (I) are characterized by having an extremely low content of cross-linking agents.

Подробнее
04-07-2006 дата публикации

Synthesis of alkylaminoalkyl (meth)acrylate by transesterification

Номер: US7071351B2
Принадлежит: Roehm GmbH Darmstadt

The invention relates to a method for transesterifying methyl methacrylate involving catalysis, particularly zirconium acetylacetonate catalysis. The obtained esters of formula (I) are characterized by having an extremely low content of cross-linking agents.

Подробнее
27-12-2018 дата публикации

PRODUCTION OF N, N- (DI) ALKYLAMINOALKYL (MET) ACRYLAMIDE OR N, N- (DI) ALKYLAMINOALKYL (MET) ACRYLATE AND THEIR QUARTERLY AMMONIUM SALTS AS CARBON STORAGE

Номер: RU2017122606A
Принадлежит: Эвоник Рём ГмбХ

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2017 122 606 A (51) МПК C07D 251/70 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2017122606, 27.06.2017 (71) Заявитель(и): ЭВОНИК РЁМ ГМБХ (DE) Приоритет(ы): (30) Конвенционный приоритет: 28.06.2016 EP 16176555.7 36 Адрес для переписки: 105082, Москва, Спартаковский пер., 2, стр. 1, секция 1, этаж 3, ЕВРОМАРКПАТ A 2 0 1 7 1 2 2 6 0 6 A R U (57) Формула изобретения 1. Способ получения N,N-(ди)алкиламиноалкил(мет)акриламида или N,N-(ди) алкиламиноалкил(мет)акрилата общей формулы (I), 2 0 1 7 1 2 2 6 0 6 (54) ПОЛУЧЕНИЕ N,N-(ДИ)АЛКИЛАМИНОАЛКИЛ(МЕТ)АКРИЛАМИДА ИЛИ N,N-(ДИ) АЛКИЛАМИНОАЛКИЛ(МЕТ)АКРИЛАТА И ИХ ЧЕТВЕРТИЧНЫХ АММОНИЕВЫХ СОЛЕЙ В КАЧЕСТЕ ФЛОККУЛИРУЮЩИХ ВСПОМОГАТЕЛЬНЫХ ВЕЩЕСТВ И ГЕЛЕОБРАЗУЮЩИХ АГЕНТОВ R U (43) Дата публикации заявки: 27.12.2018 Бюл. № (72) Автор(ы): КРИЛЛЬ Штеффен (DE), ХАРТМАНН Патрик (DE) в которой R0 обозначает водород или метил, X обозначает NH или О, R2, R3, R4 все обозначают линейный, разветвленный или циклический алкильный радикал, арильный радикал, который также может быть замещен одной или большим количеством алкильных групп, линейный, разветвленный или циклический алкильный радикал может содержать 1-12 атомов углерода и им является, например, метил, этил, пропил, изопропил, бутил, изобутил, трет-бутил, пентил, гексил, гептил, октил, изооктил, нонил, децил, ундецил, додецил, содержащих менее 1200 част./млн соединения общей формулы (IV), Стр.: 1 A 2 0 1 7 1 2 2 6 0 6 A R U 2 0 1 7 1 2 2 6 0 6 Стр.: 2 R U в которой R5 в каждом случае обозначает линейный, разветвленный или циклический алкильный радикал, арильный радикал, который также может быть замещен одной или большим количеством алкильных групп, линейный, разветвленный или циклический алкильный радикал может содержать 1-12 атомов углерода и им является, например, метил, этил, пропил, изопропил, бутил, изобутил, трет-бутил, пентил, гексил, гептил, октил, изооктил, нонил, децил, ундецил, ...

Подробнее
21-11-2007 дата публикации

Method for producing (meth) acrylic acid esters

Номер: CN100349851C
Принадлежит: BASF SE

本发明涉及一种在催化剂或催化剂混合物存在下,通过(甲基)丙烯酸酯I与醇R 2 OH的酯交换制备(甲基)丙烯酸酯IV的方法,所述醇R 2 OH所具有的碳原子比待酯化的(甲基)丙烯酸酯中的醇组分(R 1 O-)的碳原子至少多一个。其中,从酯交换的反应产物中,首先将(甲基)丙烯酸酯I基本上分离,并随后通过蒸馏分离所用的催化剂(催化剂除去);或者,首先通过蒸馏分离所用的催化剂(催化剂除去),并随后基本上分离出(甲基)丙烯酸酯I。随后,通过蒸馏,从得到的混合物中基本上分离沸点低于(甲基)丙烯酸酯IV的成分(低沸点物除去),并且随后通过蒸馏纯化(甲基)丙烯酸酯IV(蒸馏纯化)。

Подробнее
22-11-2001 дата публикации

Process for the preparation of ester quats

Номер: DE10022966A1
Принадлежит: Cognis Deutschland GmbH and Co KG

Vorgeschlagen wird ein Verfahren zur Herstellung von Esterquats, bei dem man Triglyceride mit Alkanolaminen umestert und die resultierenden Fettsäurealkanolaminester anschließend in Gegenwart von Lösungsmitteln mit Alkylhalogeniden oder Dialkylsulfaten quaterniert, welches sich dadurch auszeichnet, dass man während der Umesterung freiwerdendes Glycerin kontinuierlich aus dem Reaktionsgleichgewicht entfernt. A process for the preparation of ester quats is proposed, in which triglycerides are transesterified with alkanolamines and the resulting fatty acid alkanolamine esters are then quaternized in the presence of solvents with alkyl halides or dialkyl sulfates, which is characterized in that glycerol liberated during the transesterification is continuously removed from the reaction equilibrium.

Подробнее
22-08-2017 дата публикации

Conveyed for targeted drug and strengthen the compound of siRNA activity

Номер: CN107082747A
Принадлежит: Nitto Denko Corp

本文描述式I的化合物: 其中R 1 和R 2 独立地选自C10至C18的烷基、C12至C18的烯基、和油基;其中R 3 和R 4 独立地选自C1至C6烷基、和C2至C6链烷醇;其中X选自‑CH 2 ‑、‑S‑、和‑O‑或不存在;其中Y选自‑(CH 2 ) n 、‑S(CH 2 ) n 、‑O(CH 2 ) n ‑、噻吩、‑SO 2 (CH 2 ) n ‑、和酯,其中n=1‑4;其中a=1‑4;其中b=1‑4;其中c=1‑4;和其中Z是抗衡离子;化合物由以下结构组成:(定向分子) m ‑接头‑(定向分子) n ,其中所述定向分子是类视黄醇或脂溶性维生素,其在靶细胞上具有特异性受体;其中m和n独立地是0、1、2和3;其中接头包含聚乙二醇(PEG)或类PEG分子,以及包含这些化合物中的一种或两种的组合物和药物制剂,所述化合物对于输送治疗剂有用;和使用这些组合物和药物制剂的方法。

Подробнее
23-03-2018 дата публикации

A kind of (2,3 dioleoyl propyl group) three changes ammonio methacrylate and its production and use

Номер: CN107827762A
Принадлежит: SUZHOU SOUTHEAST PHARMACEUTICALS CO Ltd

本发明公开了一种(2,3‑二油酰基‑丙基)三化甲基氯化铵的制备方法,采用如下方法制备:首先,将3‑二甲胺基‑1,2‑丙二醇与油酸或油酰氯发生反应得到1,2‑二油酰基‑3‑二胺基‑丙烷,然后在0.1‑10兆帕下与氯甲烷发生反应得到(2,3‑二油酰基‑丙基)三化甲基氯化铵。本发明所述方法适合中试规模生产,制备得到的(2,3‑二油酰基‑丙基)三化甲基氯化铵是一种阳离子脂质体用磷脂,可作为药用辅料用于注射液、片剂、胶囊等各种类型药物。

Подробнее
09-02-2021 дата публикации

Patent RU2017122606A3

Номер: RU2017122606A3
Автор: [UNK]
Принадлежит: [UNK]

ВУ"? 2017122606” АЗ Дата публикации: 09.02.2021 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017122606/04(039143) 27.06.2017 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 16176555.7 28.06.2016 ЕР Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) ПОЛУЧЕНИЕ М,М-(ДИ)АЛКИЛАМИНОАЛКИЛ(МЕТ)АКРИЛАМИДА ИЛИ М,М- (ДИ)АЛКИЛАМИНОАЛКИЛ(МЕТ)АКРИЛАТА И ИХ ЧЕТВЕРТИЧНЫХ АММОНИЕВЫХ СОЛЕЙ В КАЧЕСТЕ ФЛОККУЛИРУЮЩИХ ВСПОМОГАТЕЛЬНЫХ ВЕЩЕСТВ И ГЕЛЕОБРАЗУЮЩИХ АГЕНТОВ Заявитель: Эвоник Оперейшнс ГмбХ, РЕ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 213/06 (2006.01) С07С 219/05 (2006.01) С07С 231/02 (2006.01) С07С 233/36 (2006.01) СОЗЕ 220/60 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С 213/06, С07С 219/08, С07С 231/02, СО7С 233/38, СО8Е 220/60 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые ...

Подробнее
29-06-2022 дата публикации

Reclamation of noble products in a method for producing (meth)acrylic ester

Номер: KR102415174B1
Принадлежит: 아르끄마 프랑스

본 발명은 경질 알킬 (메트)아크릴레이트와 중질 알코올의 에스테르교환에 의해 개선된 생산성으로 (메트)아크릴 에스테르를 제조하는 방법에 관한 것이다. 본 발명의 방법은 합성 동안 생성된 중질 분획물의 열 처리 후 회수된 귀중 생성물의 재순환을 포함하는데, 상기 열 처리는 그의 알킬 사슬이 경질 알킬 (메트)아크릴레이트의 알킬 사슬에 상응하는 디알킬 프탈레이트의 존재 하에 실행된다. 본 발명은 유리하게는 에틸 아크릴레이트로부터 N,N-디메틸아미노에틸 아크릴레이트를 제조하는데 적용된다. The present invention relates to a process for preparing (meth)acrylic esters with improved productivity by transesterification of light alkyl (meth)acrylates with heavy alcohols. The process of the present invention comprises the recycling of the recovered valuable product after heat treatment of the heavy fraction produced during synthesis, wherein the heat treatment of the dialkyl phthalate whose alkyl chain corresponds to the alkyl chain of the light alkyl (meth)acrylate run in existence. The present invention is advantageously applied to the preparation of N,N-dimethylaminoethyl acrylate from ethyl acrylate.

Подробнее
14-10-2022 дата публикации

Process for producing hexahydrofurofuranol derivative, intermediate therefor, and process for producing the intermediate

Номер: CN110372641B

本发明涉及医药合成领域,具体涉及六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法。该制备方法包括卤化反应、酰化反应、酶法还原反应、与胺类化合物反应、还原关环反应步骤, 其中,R 1 ,R 2 ,R 3 为氢或羟基保护基;R 4 ,R 5 相同或不同地为苯基,烷基或取代苯基。在六氢呋喃并呋喃醇衍生物的制备过程中,通过酶法来构建手性,采用这样的技术手段能够非常高光学纯度制备得到产物。该制备方法能商业化生产制备达芦那韦关键中间体(3R,3aS,6aR)‑六氢呋喃并[2,3‑b]‑3‑醇,是一条非常经济,适合于工业化生产的路线。

Подробнее
22-07-2010 дата публикации

Softener composition

Номер: JP2010159529A
Принадлежит: Kao Corp

【課題】良好な柔軟性を示しながら、吸水性を両立でき、且つ優れたハンドリング性を示す柔軟剤組成物を提供する。 【解決手段】一般式(I)で表される、ビス(ポリアルコキシアルカノール)型の特定の第四級アンモニウム塩を含有する柔軟剤組成物。 【選択図】なし

Подробнее
20-07-2011 дата публикации

Fabric softener and preparation method thereof

Номер: KR101050726B1
Принадлежит: 주식회사 선진화학

PURPOSE: A fiber softener and a manufacturing method thereof are provided to reduce contents of unchanged glyceride, glyceryl ester or their mixture. CONSTITUTION: The fiber softener and the manufacturing method thereof are as follows. Fatty acid hydroxyalkylamine ester includes a first ester exchange reaction, and a second ester exchange reaction. The first ester exchange reaction proceeds an exchange reaction into oil and third class hydroxyalkylamine under a pressure condition of below 50 mmHg and at 110-130 °C. The second ester exchange reaction increases temperature in the point of change of 40-60% of oil into a reactant and is proceeded at 130-160 °C. Esterquat reacts fatty acid hydroxyalkylamine ester among solvent with the quaternizing agent.

Подробнее
03-06-2021 дата публикации

Method for synthesis of dimethylaminoalkyl(meth)acrylates

Номер: RU2749072C1

FIELD: chemistry.SUBSTANCE: present invention relates to a method for synthesis of dimethylaminoalkyl(meth)acrylates from alkyl(meth)acrylate and dimethylaminoalkanol. It also relates to an application of a catalytic system containing a solution of lithium alkoxide in alcohol during synthesis of dimethylaminoalkyl(meth)acrylate. The method for synthesis of dimethylaminoalkyl(meth)acrylate is executed by a reaction of a mixture containing (a) alkyl(meth)acrylate, (b) dimethylaminoalkanol, (c) a catalytic system containing a solution of lithium alkoxide in alcohol and one or more inhibitors selected from hydroquinone monomethyl ether and 2,4-dimethyl-6-tert-butylphenol, wherein the catalytic system does not comprise alkaline earth metal compounds.EFFECT: implementation of the method according to the present invention can result in relatively high temperatures and therefore shorter reaction time values.10 cl, 2 dwg, 2 tbl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 749 072 C1 (51) МПК C07C 213/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 213/06 (2021.02) (21)(22) Заявка: 2020113482, 28.09.2018 (24) Дата начала отсчета срока действия патента: Дата регистрации: 03.06.2021 (73) Патентообладатель(и): ЭВОНИК ОПЕРЕЙШЕНС ГМБХ (DE) (56) Список документов, цитированных в отчете о поиске: GB 2162516 A, 05.02.1986. US 4672105 A, 09.06.1987. US 6706910 B2, 16.03.2004. DE 1965308 A, 16.07.1970. RU 2014145246 A, 10.06.2016. 04.10.2017 DE 10 2017 217 620.2 (45) Опубликовано: 03.06.2021 Бюл. № 16 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 06.05.2020 (86) Заявка PCT: 2 7 4 9 0 7 2 (87) Публикация заявки PCT: WO 2019/068578 (11.04.2019) C 1 C 1 EP 2018/076447 (28.09.2018) 2 7 4 9 0 7 2 Приоритет(ы): (30) Конвенционный приоритет: R U R U 28.09.2018 (72) Автор(ы): ТРЕСКОВ, Марцель (DE), КРЮГЕР, Торстен (DE), ЩЮЦ, Торбен (DE), КРИЛЛЬ, Штеффен (DE) Адрес для переписки: 123242, Москва, пл. ...

Подробнее
12-08-2015 дата публикации

The preparation method of tapentadol hydrochloride and the compound for the preparation of tapentadol hydrochloride

Номер: CN103159633B
Принадлежит: Nhwa Pharmaceutical Corp

本发明公开了一种他喷他多的制备方法及用于制备他喷他多的化合物,所述制备方法,包括以式V化合物的盐酸盐为原料制备他喷他多的步骤,其特征在于,所述的式V化合物的盐酸盐制备方法,包括如下步骤:在溶剂中,将式IV化合物的盐酸盐,在氢解试剂和催化剂存在下反应,然后从反应产物中收集式V化合物的盐酸盐,本工艺无需经过手性柱拆分,保护基烯丙基的脱除条件温和;收率较高,易于工业化生产。反应式如下。

Подробнее
05-08-2014 дата публикации

Fabric softener active composition

Номер: KR101426635B1
Принадлежит: 에보니크 데구사 게엠베하

아민 모이어티에 대한 지방산 모이어티의 몰비가 1.5 내지 1.99이고 지방산 모이어티의 평균 사슬 길이가 16 내지 18개의 탄소 원자이고 지방산 모이어티의 아이오딘가가, 유리 지방산으로부터 계산했을 때, 0.5 내지 50인 비스-(2-히드록시프로필)-디메틸암모늄 메틸술페이트 지방산 에스테르 50중량% 이상, 및 지방산 0.5 내지 5중량%를 포함하는 섬유 유연제 활성 조성물은, 높은 유연화 성능 및 수성 분산액 중에서의 우수한 저장 안정성을 제공하고, 인화성 용매의 첨가 없이 액체 상태로 취급 및 가공할 수 있다. Wherein the molar ratio of the fatty acid moiety to the amine moiety is from 1.5 to 1.99 and the average chain length of the fatty acid moiety is from 16 to 18 carbon atoms and the iodine value of the fatty acid moiety is from 0.5 to 50, (2-hydroxypropyl) -dimethylammonium methylsulfate fatty acid esters, and 0.5 to 5 wt.% Fatty acids, provide high softening performance and good storage stability in aqueous dispersions , And can be handled and processed in a liquid state without adding a flammable solvent.

Подробнее
02-08-2016 дата публикации

Method of manufacturing DMAEA and Apparatus therefor

Номер: KR101644629B1
Автор: 이종천
Принадлежит: 이종천

The present invention relates to a method and an apparatus for producing dimethylaminoethyl acrylate (DMAEA). According to the present invention, the method for producing DMAEA comprises the following steps: preparing a column-type reactor; and supplying acrylate and dimethylaminoethanol (DMAE) to the reactor, wherein the DMAE and acrylate are supplied to the reactor through an additional stream, and the DMAE is supplied from an upper part than a portion where acrylate is supplied from.

Подробнее
13-12-2007 дата публикации

Accelerated synthesis of substituted hydroxymethyl phenols

Номер: WO2007140965A1
Автор: Bryan Kennedy, Seth Ennis
Принадлежит: Schwarz Pharma Ltd.

This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof , comprising the following steps: a) adding to a suspension of Mg a compound of formula (II) R1 (MgX)n- LiY wherein n is 1 or 2; R1 is an aromatic, aliphatic, carbocyclic or heterocyclic organic group having 1 to 24 carbon atoms; X and Y are independently selected from Cl, Br and I, b) reacting said reaction mixture with a suitable halogenated compound in a solvent to form a Grignard reagent, c) reacting said Grignard reagent with a suitable linear, branched or cyclic carbonate to obtain a compound of formula (IV) wherein A is a linear, branched or cyclic C1-C6 alkyl group, and preferably a methyl group, and then further reacting the compound of formula (IV) in a known manner to obtain a compound of formula (I) and optionally salt formation.

Подробнее
21-12-2007 дата публикации

Shortened synthesis using paraformaldehyde or trioxane

Номер: WO2007144091A1
Принадлежит: Schwarz Pharma Ltd.

The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.

Подробнее
30-10-2012 дата публикации

Accelerated synthesis of substituted hydroxymethyl phenols

Номер: US8299306B2
Принадлежит: UCB Manufacturing Ireland Ltd

This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C 1 -C 6 alkyl-carbonyl group or a phenylcarbonyl group, or a salt thereof, comprising the following steps: a) adding to a suspension of Mg a compound of formula (II) R 1 (MgX) n —LiY wherein n is 1 or 2; R 1 is an aromatic, aliphatic, carbocyclic or heterocyclic organic group having 1 to 24 carbon atoms; X and Y are independently selected from Cl, Br and I, b) reacting said reaction mixture with a suitable halogenated compound in a solvent to form a Grignard reagent, c) reacting said Grignard reagent with a suitable linear, branched or cyclic carbonate to obtain a compound of formula (IV) wherein A is a linear, branched or cyclic C 1 -C 6 alkyl group, and preferably a methyl group, and then further reacting the compound of formula (IV) in a known manner to obtain a compound of formula (I) and optionally salt formation.

Подробнее
14-02-2012 дата публикации

Shortened synthesis using paraformaldehyde or trioxane

Номер: US8115028B2
Принадлежит: Schwarz Pharma Ltd

The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C 1 -C 6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.

Подробнее
01-06-2021 дата публикации

Method for simultaneously producing bis (dimethylaminoethyl) ether and tetramethylethylenediamine

Номер: CN112876371A
Автор: 叶开天, 张超, 李珍名

本发明公开了一种能同时生产双(二甲氨基乙基)醚和四甲基乙二胺的方法,以CN110028413A的步骤1)所得的醚化液为原料,包括以下步骤:在反应器中设置氢氧化钠水溶液,于搅拌条件、50℃~回流条件下向反应器中滴加醚化液形成反应体系,反应体系在反应器中进行蒸馏,通过汽升管一进入分离加热段中进行精馏,精馏蒸出水的一部分经过回流管进行循环套用,直至馏分经检测DMEA含量小于1%后停止套用,反应器停止蒸馏;分离加热段中的物料进行精馏,分别得水馏分、TMEDA馏分、DMEA馏分、BDMAEE馏分。

Подробнее
25-08-2020 дата публикации

Systems and methods for producing a chemical product

Номер: US10751685B2
Принадлежит: PURDUE RESEARCH FOUNDATION

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

Подробнее
10-08-2014 дата публикации

Active fabric softener composition

Номер: RU2524954C2
Принадлежит: Эвоник Дегусса Гмбх

Изобретение относится к активным композициям мягчителя ткани. Описана активная композиция мягчителя ткани, содержащая a) не менее 50 мас.% бис-(2-гидроксипропил)-диметиламмонийметилсульфатного эфира жирной кислоты, обладающего отношением количества молей фрагментов жирной кислоты к количеству молей аминных фрагментов, равным от 1,5 до 1,99, средней длиной цепи фрагментов жирной кислоты, составляющей от 16 до 18 атомов углерода, и йодным числом для фрагментов жирной кислоты, рассчитанным для свободной жирной кислоты, равным от 0,5 до 50, и b) от 0,5 до 5 мас.% жирной кислоты, также описан способ получения композиции мягчителя ткани. Технический результат - хорошая смягчающая способность, хорошая стабильность при хранении в водной дисперсии, при этом композиции мягчителей можно использовать и перерабатывать в жидком состоянии без добавления воспламеняющегося растворителя. 2 н. и 13 з.п. ф-лы, 2 табл., 19 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 524 954 C2 (51) МПК C11D 1/62 (2006.01) C11D 3/00 (2006.01) C11D 3/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012146402/04, 18.03.2011 (24) Дата начала отсчета срока действия патента: 18.03.2011 Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): Ханс-Юрген КЁЛЕ (DE), Ульрике КОТТКЕ (DE), Харальд ЯКОБ (DE), Йенс ХИЛЬДЕБРАНД (US) (43) Дата публикации заявки: 10.05.2014 Бюл. № 13 R U (73) Патентообладатель(и): ЭВОНИК ДЕГУССА ГМБХ (DE) 01.04.2010 US 61/319,950 (45) Опубликовано: 10.08.2014 Бюл. № 22 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 01.11.2012 (86) Заявка PCT: EP 2011/054107 (18.03.2011) (87) Публикация заявки PCT: 2 5 2 4 9 5 4 (56) Список документов, цитированных в отчете о поиске: EP 1018541 A1, 12.07.2000 (см. прод.) 2 5 2 4 9 5 4 R U Адрес для переписки: 105082, Москва, Спартаковский пер., д. 2, стр. 1, секция 1, этаж 3, "Евромаркпат" (54) АКТИВНАЯ КОМПОЗИЦИЯ МЯГЧИТЕЛЯ ТКАНИ (57) Реферат: Изобретение относится ...

Подробнее