ПРОИЗВОДНЫЕ БЕНЗИМИДАЗОЛОНА И ХИНАЗОЛИНА КАК АГОНИСТЫ ORL1-РЕЦЕПТОРОВ ЧЕЛОВЕКА

Изобретение относится к новым соединениям общей формулы (1), их оптически активным стереоизомерам, а также фармакологически пригодным солям, обладающим свойствами ORL1 и µ-опиатных рецепторов. Соединения могут быть использованы для приготовления лекарственного средства для лечения нарушений и заболеваний, таких как нарушения пищевого поведения, артериальная гипертензия. В общей формуле (1) ! ! R1 представляет собой Н, алкил(1-6С), []m означает -(СН2)m-, в котором m равно 0 или 1, R2 представляет собой галоген, СF3, алкил(1-6С), фенил, циано, цианоалкил(1-3С), гидрокси, (1-3С)алкокси, ОСF3, ацил(2-7С), трифторацетил, (1-3С)алкилсульфонил или трифторметилсульфонил, и n означает целое число 0-4 при условии, что, когда n равно 2, 3 или 4, заместители R2 могут быть одинаковыми или разными, А означает насыщенное кольцо, ! []о и []р представляют собой -(СН2)о- и -(СH2)р, и о и р независимо соответствуют 0, 1 или 2, R3, R4, R5 и R6 независимо представляют собой водород, алкил(1-3С), или (R4 и R6 ...

ПРОИЗВОДНЫЕ БЕНЗИМИДАЗОЛОНА И ХИНАЗОЛИНА КАК АНГОНИСТЫ ORL-РЕЦЕПТОРОВ ЧЕЛОВЕКА

... 1. Соединения общей формулы (1) в которой R1 представляет собой Н, алкил(1-6С), алкил(1-3С)циклоалкил(3-6С), карбалкокси(2-7С) или ацил(2-7С), []m означает -(CH2)m-, в котором m равно 0 или 1, R2 представляет собой галоген, CF3, алкил(1-6С), алкил(1-3С)циклоалкил(3-6С), фенил, амино, аминоалкил(1-3С), алкил(1-3С)амино, диалкил(1-3С)амино, циано, цианоалкил(1-3С), гидрокси, гидроксиалкил(1-3С), (1-3С)алкокси, OCF3, ацил(2-7С), трифторацетил, аминокарбоксил, (1-3С)алкилсульфонил или трифторметилсульфонил, и n означает целое число 0-4, при условии, что, когда n равно 2, 3 или 4, заместители R2 могут быть одинаковыми или разными, А означает насыщенное или частично насыщенное кольцо, []о и []р представляют собой -(СН2)о- и -(СН2)р соответственно, при условии, что также значение -СН- возможно, когда А представляет собой частично ненасыщенное кольцо, и о и р независимо соответствуют 0, 1 или 2, R3, R4, R5 и R6 независимо представляют собой водород, алкил(1-3С), алкил(1-3С)циклоалкил(3-6С), СН2ОН ...

PROCEDURE FOR THE PRODUCTION OF A IMINZWISCHENPRODUKTS

POLYMERIZATION PROCEDURE FOR OLEFINEN

Use of natural vegetable components as flavouring agents in the coating of chewing gum

Iminoalcohol-oxazolidine mixtures and their use

CATALYSTS CONTAINING PER-ORTHO ARYL SUBSTITUTED ARYL OR HETEROARYL SUBSTITUTED NITROGEN DONORS

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising two nitrogen donor atoms independently substituted by an aromatic of heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are proceses for the polymerization of olefins using the catalyst compositions.

SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS

This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

AMINOPROPANOL DERIVATIVES, THESE CONNECTIONS AS ACTIVE SUBSTANCE ABSTENTION OF DRUG PREPARATIONS AS WELL AS PROCEDURES FOR THE PRODUCTION THE SAME.

ENAMINE QUATERNARY COMPOUNDS, METHODS OF MAKING AND THEIR USE AS MUSCLE RELAXANTS

ＵＶ 차단을 위한 국소용 제형

... 2-가지 사이클릭 구조를 갖는 신규한 화합물이 기술된다. 이러한 신규한 화합물은 자외선(UV)-A 및 UV-B 방사선 둘 모두를 흡수하고, 피검체의 피부에 적용될 때 광보호성인 국소 조성물을 형성시키기 위해 약제학적으로 허용 가능한 부형제와 제형화된다. 신규한 화합물의 광보호 성질을 측정하는 방법, 및 기술된 바와 같이 제형화된 국소 조성물의 적용을 통해 일광 화상 또는 일광 손상에 대해 보호하는 방법이 기술된다.

ENANTIOSELECTIVE ADDITION OF HYDROCARBONS TO ALPHA,BETA-UNSATURATED CARBONYL COMPOUNDS

The conjugate addition of hydrocarbon equivalents to alpha,beta-unsaturated carbonyl compounds using a series of novel catalysts is described. The catalysts comprise copper(I) complexes with ligand systems comprising either tropocoronand macrocycles or N,N'-dialkylsubstituted aminotroponeimines.

Disazo disulfonamides compounds

The new azo compounds are represented by the following general formula I см. иллюстрацию в PDF-документе Wherein R and R1 are hydrogen, --COCR34 --COCHR24, --SO2 CH3, --CO2 C2 H5, --CH2 CH2 R4, --( CH2 CH2 R4)2, --CH2 CH2 OH, --CONHCH2 CH2 R4 or --CH2 CH2 OCONH2 and R4 is Cl or a group of the formula см. иллюстрацию в PDF-документе --NHCO2 CH3 CH2 OH, --NHCO2 C2 H5, --NHOH, --NHCONHOH, or --NHCH3, whereby R1 and R2 are similar or dissimilar.

Bis(arylimino)acenaphthene nickel(II) complexes

Certain olefins such as ethylene, α-olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium α-diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or a catalyst system containing certain nickel[II] or palladium[II] compounds, an α-diimine, a metal containing hydrocarbylation compound, and optionally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

MICHAEL ADDITION PRODUCT AND SCHIFF'S BASE AROMACHEMICALS

Derivatives of N-phenyl-trinitrofluorenonimine and electron transporting material

The present invention provides trinitrofluorenonimine derivatives which are represented by formulae (I)-(IV) of which formula (I) is an example wherein R1, R2 and R3 are the same or different and indicate an alkyl group which may have a substituent. Such a derivative is superior in electron transferring capability. Accordingly, the electro-photosensitive material having the photosensitive layer containing this derivative is superior in sensitivity. ...

Electrophotographic photoreceptor

An electrophotographic photoreceptor is disclosed. The photoreceptor contains a 9-substituted imidefluorene as a electron transfermaterial as defined in the specification. It provides a multilayered photoreceptor for positive charge having an excellent electron transferability.

VERWENDUNG NATUERLICHER PFLANZLICHER KOMPONENTEN ALS GESCHMACKSWIRKSTOFFE ZUM BESCHICHTEN VON KAUGUMMI

VERFAHREN ZUR HERSTELLUNG VON AZOMETHINEN

Michael addition product and schiff's base aromachemicals

Compounds and their use

NEUE AMINOPROPOXYIMINO-CYCLOALKANDERIVATE, DEREN HERSTELLUNG, ARZNEIMITTEL, DIE DIESE VERBINDUNGEN ALS WIRKSTOFF ENTHALTEN SOWIE VERFAHREN ZUR HERSTELLUNG DERSELBEN

USE OF NATURAL OF VEGETABLE COMPONENTS AS TASTE ACTIVE SUBSTANCES FOR COATING CHEWING RUBBER

Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors

Small molecules for the modulation of MCL-1 and methods of modulatiing cell death, cell division, cell differentiation and methods of treating disorders

This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS

... 2108889 9221660 PCTABS00017 Certain tricyclic polyhydroxylic compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).

USE OF NATURAL VEGETABLE COMPONENTS AS FLAVOURING AGENTS IN CHEWING GUM COATING

APPLICATION OF NATURAL VEGETABLE COMPONENTS AS AROMATIC AGENTS IN THE COATING CHEWING GUM

ПОХІДНІБЕНЗІМІДАЗОЛОНУ ТА ХІНАЗОЛІНОНУ ЯК АГОНІСТИ ЛЮДСЬКИХ РЕЦЕПТОРІВ ORL1

Винахід стосується групи нових похідних бензімідазолону та хіназолінону, які є агоністами людських рецепторів ORL1 (ноцицептину). Винахід стосується також одержання цих сполук, фармацевтичних композицій, які містять фармакологічно дієву кількість принаймні одного з цих похідних бензімідазолону та хіназолінону як діючу речовину, а також застосування цих фармацевтичних композицій для лікування розладів, пов'язаних з рецепторами ORL1. Винахід стосується сполук загальної формули (1) , (1) де позначки мають значення, наведені в описі.

Process for the production of 1, 5-naphthalenediamine and 1,5-naphthalenediisocyanate

ALPHA,BETA-UNSATURATED IMINES

COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT

Embodiments of the present disclosure provide compositions including ketamine analogues, salts, and disalts, pharmaceutical compositions including ketamine analogues, salts, or disalts, methods of treatment of a condition or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

SEPARATION OF UNSYMMETRICAL DIIMINES BY LIQUID CHROMATOGRAPHY

Novel unsymmetrical diimines containing a polar group are made by preparing a mixture of the unsymmetrical diimine and two symmetrical diimines, for example by reacting a dicarbonyl compound with two primary amines. The unsymmetrical diimine is then purified by liquid chromatography. The unsymmetrical diimines are useful as ligands in olefin polymerization catalysts.

N-cycloalkyl substituted-10,11-dihydro 5H-dibenzo[a,d] cyclohepten-5-imines

... 5H-dibenzo[a,d]cyclohepten-5-imines having a cyclic alkyl group, such as cyclopropyl or cyclobutyl, and their 10,11-dihydro derivatives, are useful as plasticizers for polymers and also for their effect on the central nervous systems of mammals.

Complexes of AZO compounds and/or their salts and an antitumor agent and a method for reducing the growth of tumors

A complex of an azo compound of the formula см. иллюстрацию в PDF-документе wherein R and R' are selected from the group consisting of hydrogen, --COCR43, --COCHR24, --CO2 C2 H5, --CH2 CH2 R4, --(CH2 CH2 R4)2, --CH2 CH2 OH, --CONHCH2 CH2 R4 and --CH2 CH2 OCOHN2, R4 is selected from the group consisting of chlorine, см. иллюстрацию в PDF-документе --NHCO2 CH2 CH2 OH, --HNCO2 C2 H5, --NHOH, --NHCONHOH and --NHCH3 ; R1 and R2 are individually selected from the group consisting of см. иллюстрацию в PDF-документе --NHCH2 CH2 Cl, --NHCONHOH, --NHCO2 C2 H5, 6-mercapropurin, 5-fluoruracil and prenissolin, R3 is selected from the group consisting of hydrogen, --COCHR24, --SO2 CH3, --COC2 H5, --CH2 CH2 R4 and --CONH2, R4 is the same as defined herein above, or their pharmaceutically acceptable metal salts, and an antitumor agent selected from the group consisting of nitrogen mustard, cyclophosphamid, thyothepa, 6-mercaptopurine, 5-fluoruracil, vinblastine, L-asparaginase and prednisolone and treatment ...

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ АМИНОПРОПАНОЛА

Сущность: продукт-производные пропанола ф-лы 1. Реагент 1: соединение ф-лы 2. Реагент 2: соединение ф-лы 3. Реагент 3: соединение ф-лы 4. Структура соединений ф-лы 1, 2, 3, 4: (R)(R1)C6H4- CH2(R2)CH2(R3)-C = N-O-CH2-CH2)OH-(CH2)n -CH2-NR4, R5 (I) (R)(R1C6H4-CH2(R2)-CH2(R3-)-C = A (1) H-NR4R5 (3) 6 табл.

NEUE AMINOPROPOXYIMINO-CYCLOALKANDERIVATE, DEREN HERSTELLUNG, ARZNEIMITTEL, DIE DIESE VERBINDUNGEN ALS WIRKSTOFF ENTHALTEN SOWIE VERFAHREN ZUR HERSTELLUNG DERSELBEN

The invention relates to novel racemic or optically active aminopropanol derivatives of formula I I wherein R and R1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group, R2 and R3 together represent a chemical bond or independently stand for a hydrogen atom, R4 and R5 are independently hydrogen atom, C3-7 cycloalkyl group or straight or branched, saturated or unsaturated C1-12 alkyl group optionally substituted by one or more dialkylaminoalkyl, dimethoxyphenyl or phenyl groups, or R4 and R5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoromethyl groups, or R4 and R5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a ...

IMINOALKOHOL OXAZOLIDIN MIXTURES AS HUMIDITY TARGETS.

ANTI-AGING AGENTS FOR RUBBER VULCANIZATES BASED ON ORGANIC COMPOUNDS CONTAINING CONJUGATES AZADIENES

The present invention relates to anti-aging agents based on organic compounds containing conjugated azadiene groups, which are capable of providing rubber vulcanizates with long-term protection against thermal aging, fatigue and aging as a result of the effects of oxygen. The anti-aging agents according to the present invention are further characterized in that they are hardly ever extracted from the vulcanizates by water, oils and/or gasolines or hydraulic fluids.

POLYMERIZATION PROCESSES FOR OLEFINS

Certain olefins such as ethylene, .alpha.-olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium .alpha.-diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or catalyst system containing certain nickel[II] or palladium[II] compounds, an .alpha.-diimine, a metal containing hydrocarbylation compound, and optimally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

PHENALENIMINE FLUORESCENT DYES AND THEIR USE IN ANALYTICAL METHODS

METHOD FOR THE PRODUCTION OF 1,5-NAPHTHALENEDIAMINE

The invention relates to a method for the production of 1,5-naphthalenediamine and the intermediates obtained in the course of said synthesis, 4-(2-nitrophenyl)-butyronitrile, 5-nitro-3,4-dihydro-1(2H)-naphthylimine, 5-nitroso-1-naphthylamine, 5-nitro-1-naphthylamine, 4-(2-aminophenyl)-butyronitrile, 5-amino-3,4-dihydro-1(2H)-naphthalenimine, ethyl 4-(2-nitrophenyl)-butyrate and 4-(2-nitrophenyl)-butyramide.

CATALYSTS CONTAINING PER-ORTHO ARYL SUBSTITUTED ARYL OR HETEROARYL SUBSTITUTED NITROGEN DONORS

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising two nitrogen donor atoms independently substituted by an aromatic of heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are proceses for the polymerization of olefins using the catalyst compositions.

Использование N-[(1RS,2RS)-камфан-2-ил]-4-метоксианилина в качестве противостарителя для резиновой смеси на основе бутадиен-нитрильного каучука

Изобретение относится к использованию N-[(1RS,2RS)-камфан-2-ил]-4-метоксианилина в качестве противостарителя для резиновой смеси на основе бутадиен-нитрильного каучука. Изобретение обеспечивает разработку нового противостарителя, обеспечивающего резиновым изделиям стойкость к термоокислительному старению. 1 табл., 4 пр.

RACEMISCH SERTRALIN SYNTHESIS

NOVEL ALKALINE EARTH METAL COMPLEXES AND USE THEREOF

Pro-fragrance and pro-flavorant compositions

ENAMINE QUATERNARY COMPOUNDS, METHODS OF MAKING AND THEIR USE AS MUSCLE RELAXANTS

UROLITHIN A AND DERIVATIVES THEREOF FOR USE IN THERAPY

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

미생물을 사용한 미코스포린 유사 아미노산을 생산하는 방법

... 본 발명은 미코스포린 유사 아미노산(MAA)을 생산하는 방법이며, MAA를 균체 외에서 산생하는 미생물을 배양하는 공정, 균체와 균체 외 배양액을 분리하는 공정, 및 균체 외 배양액으로부터 MAA를 회수하는 공정을 포함하는 방법, 하기 식 1로 표시되는 MAA, 본 발명의 방법에 의해 생산되는 MAA 또는 하기 식 1로 표시되는 MAA를 포함하는 자외선 흡수용 조성물, 및 급성 피부 반응, 피부 노화 및 피부암으로 이루어지는 군에서 선택되는 1 이상의 증상 또는 질환을 예방하기 위한, 본 발명의 방법에 의해 생산되는 MAA 또는 하기 식 1로 표시되는 MAA를 포함하는 조성물을 제공한다.

مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية

Çelatlama maddeleri ve manganik çelatları.

MICHAEL ADDITION PRODUCT AND SCHIFF'S BASE AROMACHEMICALS

A pro-odorant or pro-flavorant having the formula (I): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; R3, R4 and R6 are each independently hydrogen or organic moieties which together with C(O)R5 render a compound of formula R5C(O)R6C=CR3R4 a material having odorant or flavourant characteristics and R5 is hydrogen or an organic moiety; or having the formula (II): R8R9C=NR10 wherein R10 is an aliphatic group or an aromatic group having at least 10 carbon atoms; R8 and R9 are each independently hydrogen or organic moieties which together with C=O render a compound of formula R8R9C=O a material having odorant or flavourant characteristics, provided that only one of R8 and R9 is hydrogen; or having the formula (III): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number ...

PRO-FRAGRANCE AND PRO-FLAVORANT COMPOSITIONS

A pro-odorant or pro-flavorant that is liquid at room temperature and has a relatively low viscosity and has the formula (I): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; R5 is CN, COOH, COOR7, CHO or C(O)R8; R3, R4 and R6 are each independently hydrogen or organic moieties which together with R5 render a compound of formula R5R6C=CR3R4 a material having odorant or flavourant characteristics and R7 and R8 are each independently an organic moiety; or the formula (II): R9R10C=NR11 wherein R11 has at least 10 carbon atoms and is an aliphatic group or an aromatic group; R9 and R10 are each independently H or organic moieties which together with C=O render a compound of formula : R9R10C=O a material having odorant or flavourant characteristics, provided that only one of R9 and R10 is hydrogen; or the formula (III): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; Z is CH2 or O, n is 0 or 1, such that the ring is a 5 or 6 membered ring, R12 is H, alkyl or alkenyl or alkoxy having up to 10 carbon atoms so as to render a compound of formula (V): a material having odorant or flavorant characteristics; or formula (IV): wherein R11 has at least 10 carbon atoms and is an aliphatic group or an aromatic group; the or each R13 is independently a straight or branched chain, saturated or unsaturated hydrocarbyl group or alkoxy group having from 1 to 8 carbon atoms or two groups R13 together with the carbon atoms to which they are attached form a five or six membered ring which may be saturated or unsaturated (including aromatic) and which may be optionally substituted with from 1 to 3 alkyl groups having from 1 to 6 carbon atoms; and x is from 1 to 5 so as to render a compound of formula (VI): a ...

Iminoalcohol-oxazolidine mixtures and their use

Methods of using a mixture as a corrosion inhibitor, moisture or formaldehyde scavenger, reactive diluent, rheological modifier, thermoplastic foam inhibitor, antifreezing agent, decolorizing agent, or drying agent. The mixture consists of from 0 to 100 mole percent of an iminoalcohol compound: см. иллюстрацию в PDF-документе wherein: R1 is a methyl or methylol group, an ethyl or ethylol group, a branched or straight chain alkyl or alkanol group, a cycloalkyl group, or an aryl group; R2 is a hydrogen atom, a methyl or methylol group, an ethyl or ethylol group, a straight chain or branched chain alkyl or alkanol group, a cycloalkyl group, or an aryl group, or R1 and R2 are fused together with the attached carbon to form a cycloalkane ring; R3, R4 and R5 are, individually, a hydrogen atom, a methyl or methylol group, an ethyl or ethylol group, or a straight chain or branched chain alkyl or alkanol group; R6 is a hydrogen atom, a methyl group, an ethyl group, or a straight chain or branched ...

Catalytic enantioselective addition of hydrocarbon equivalents to alpha, beta-unsaturated carbonyl compounds

The conjugate addition of Grignard reagents to alpha, beta-unsaturated carbonyl compounds using a series of novel catalysts is described. The catalysts comprise copper(I) complexes with ligand systems comprising either tropocoronand macrocycles or N,N'-dialkylsubstituted aminotroponeimines.

Catalysts containing N-pyrrolyl substituted nitrogen donors

Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise metal complexes of mono through tetradentate ligands comprising N-pyrrolyl substituted nitrogen donors bonded to the metal. Also disclosed are processes for the polymerization or oligomerization of olefins using the catalyst compositions.

Single-site catalysts based on caged diimide ligands

Single-site catalysts useful for polymerizing olefins are disclosed. The organometallic catalysts incorporate a Group 3 to 10 transition, lanthanide or actinide metal and a caged diimide ligand. The diimide ligands are made by a tandem Diels-Alder and photochemical [2+2] cycloaddition sequence to give a multicyclic dione, followed by condensation with a primary amine. Because a wide variety of caged diimide ligands are easy to prepare from commercially available dienes and dienophiles, the invention enables the preparation of a new family of single-site catalysts. Based on their unique structure and geometry, the catalysts offer polyolefin producers new ways to improve activity, control comonomer incorporation, or regulate polyolefin tacticity.

Alkaline earth metal complexes and their use

Chelate complexes of calcium, strontium and barium formed with ligands that are beta-ketiminate compounds having a scorpion tail; intermediate compounds useful in producing the aforementioned complexes; a method for producing such complexes, and the use of such complexes for depositing layers containing calcium, barium or strontium.

Azasteroidal mimics

An azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic is formed via an oxocycloalkenyl isoxazolium anhydrobase and its dimer. The dimer can be used to form mono- and dihydrazones, which can be an azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic. A method of preparation of the dimer and the azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic occurs with hydrazonation and, optionally, a subsequent dehydrazonation. The dimer can be converted by inserting a nitrogen atom into the six membered ring of to a C-17 position cyclohexenone moiety of the dimer to yield a reduced tetrazolo[1,5-a]azepin-8-yl group. A subsequent hydrozone formation at a benzylic ketone can be carried out to generate an azasteroid mimic with a (triazol-4-yl)imino substituent. Monohydrazones can be converted to their thione equivalents.

Productivity catalysts and microstructure control

Improved Group 3-11 transition metal based catalysts and processes for the polymerization of olefins are described. Some of the ligands are characterized by a preferred substitution pattern which allows for higher productivities of highly branched olefins; substitution patterns which boost productivity or alter the polymer microstructure are also described.

ИМИНОПРОИЗВОДНЫЕ КАМФОРЫ, СОДЕРЖАЩИЕ АРОМАТИЧЕСКИЙ ИЛИ ГЕТЕРОАРОМАТИЧЕСКИЙ ФРАГМЕНТ, - ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ГРИППА (штамм A/California/07/09 (H1N1)pdm09)

FIELD: medicine. SUBSTANCE: invention relates to medicine and pharmaceutics, namely to use of camphor imine derivatives of general formula I, where n=0, 1, 2; X=CH or N, R – hydroxy, alkoxy group, as inhibitors of reproduction of flu virus (strain A/California/07/09(H1N1)pdm09). EFFECT: said imine compounds exhibit evident antiviral activity along with low toxicity. 1 cl, 1 tbl, 10 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 607 451 C1 (51) МПК C07C 251/20 (2006.01) C07D 213/53 (2006.01) A61K 31/13 (2006.01) A61K 31/4406 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ 2015143596, 12.10.2015 (24) Дата начала отсчета срока действия патента: 12.10.2015 Дата регистрации: Приоритет(ы): (22) Дата подачи заявки: 12.10.2015 (45) Опубликовано: 10.01.2017 Бюл. № 1 C 1 2 6 0 7 4 5 1 (56) Список документов, цитированных в отчете о поиске: В.Н. ЦАРЕВ и др., Первый R U P,N-бидентатный фосфит с хиральным кетиминным фрагментом. Каталитические свойства его комплексов с Rh I и Pd II и их сравнение со свойствами фосфиновых аналогов, ИЗВЕСТИЯ АКАДЕМИИ НАУК. СЕРИЯ ХИМИЧЕСКАЯ, 2004, 9, стр.1942-1945. B.E. LOVE et al., Synthesis of Sterically Hindered Imines, J. ORG. CHEM., 1993, Vol. 58, (см. прод.) (54) ИМИНОПРОИЗВОДНЫЕ КАМФОРЫ, СОДЕРЖАЩИЕ АРОМАТИЧЕСКИЙ ИЛИ ГЕТЕРОАРОМАТИЧЕСКИЙ ФРАГМЕНТ, - ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ГРИППА (штамм A/California/07/09 (H1N1)pdm09) (57) Формула изобретения Стр.: 1 C 1 (73) Патентообладатель(и): Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (RU), Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ гриппа" Минздрава России) (RU), Общество с ограниченной ответственностью "Инновационные Фармакологические Разработки" (ООО "Ифар") (RU) 2 6 0 7 4 5 ...

(Aminopropoxyimino)-cycloalkanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

N-PHENYL-2,2,6,6-TETRAHALOGENCYCLOHEXANIMIN UND VERFAHREN ZUR HERSTELLUNG VON DERIVATEN DES 2,2,6,6-TETRAHALOGENCYCLOHEXANIMINS UND VON DERIVATEN DES 2,6-DIHALOGENANILINS.

POLYMERISATIONSVERFAHREN FÜR OLEFINEN

Pro-fragrance and pro-flavorant compositions

NOVEL AMINOPROPANOL DERIVATIVES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

N-(SUBSTITUTED BENZYLOXY)IMINE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF, USE THEREOF, AND METHOD OF USE THEREOF

REDUCTION OF HAIR GROWTH

Compositions including a conjugate of .alpha.-difluoromethylornithine can be applied topically to reduce hair growth.

SINGLE-SITE CATALYSTS BASED ON CAGED DIIMIDE LIGANDS

Single-site catalysts useful for polymerizing olefins are disclosed. The organometallic catalysts incorporate a Group 3 to 10 transition, lanthanide or actinide metal and a caged diimide ligand. The diimide ligands are made by a tandem Diels-Alder and photochemical [2+2] cycloaddition sequence to give a multicyclic dione, followed by condensation with a primary amine. Because a wide variety of caged diimide ligands are easy to prepare from commercially available dienes and dienophiles, the invention enables the preparation of a new family of single-site catalysts. Based on their unique structure and geometry, the catalysts offer polyolefin producers new ways to improve activity, control comonomer incorporation, or regulate polyolefin tacticity.

N-(SUBSTITUTED BENZYLOXY)IMINE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF, USE THEREOF, AND METHOD OF USE THEREOF

Compound of the general formula (I), which is useful as an agricultural and horticultural fungicide, an agricultural and horticultural fungicidal composition containing the compound, use of the composition for controlling plant disease, and process for the production of the compound: (I) wherein: R1 and R2 each independently represent a C1-C6 alkyl group; one of R3 and R4 represents a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6 alkoxy group, a C1-C6 alkoxy-C1-C6 alkyl group, a phenyl group or d benzyloxy group, and the other is a nitrogen atom-containing hetero ring which is selected from the group consisting of pyrrolidino, piperidine, morpholine, thiomorpholine, piperazine, hexamethyleneimine, tetrahydroquinoline, tetrahydroisoquinoline, 2,3-dihydro-1,4-benzoxazine and octahydro-1,4-benzoxazine and which is attached at its nitrogen atom to the rest of the derivative, the nitrogen atom-containing hetero ring being unsubstituted or substituted by at least one substituent selected ...

N-(SUBSTITUTED BENZYLOXY)IMINE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF, USE THEREOF, AND METHOD OF USE THEREOF

PREPOLYMER, PREPOLYMER COMPOSITION, HIGH MOLECULAR WEIGHT POLYMER HAVING STRUCTURE CONTAINING HOLE AND ELECTRICALLY INSULATING FILM

A prepolymer, characterized in that it is prepared by the reaction of two compounds A and B which have two or more functional moieties or two or more groups of functional moieties, respectively, and are capable of undergoing a polymerization through the bonding of a functional moiety or a group of functional moieties of one compound with a functional moiety or a group of functional moieties of the other compound to form a high molecular weight polymer having a structure containing a hole. The prepolymer has a weight average molecular weight of ca. 200 to 100000. In a preferred embodiment, the compound A has a carboxyl moiety or an amino moiety as the above functional moiety or a group of functional moieties, and the compound B has two amino moieties, an amino moiety and a hydroxyl moiety, an amino moiety and a mercapto moiety, or two carboxyl moieties as the above functional moiety or a group of functional moieties. © KIPO & WIPO 2007 ...

MICHAEL ADDITION PRODUCT AND SCHIFF'S BASE AROMACHEMICALS

A pro-odorant or pro-flavorant having the formula (I): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; R3, R4 and R6 are each independently hydrogen or organic moieties which together with C(O)R5 render a compound of formula R5C(O)R6C=CR3R4 a material having odorant or flavourant characteristics and R5 is hydrogen or an organic moiety; or having the formula (II): R8R9C=NR10 wherein R10 is an aliphatic group or an aromatic group having at least 10 carbon atoms; R8 and R9 are each independently hydrogen or organic moieties which together with C=O render a compound of formula R8R9C=O a material having odorant or flavourant characteristics, provided that only one of R8 and R9 is hydrogen; or having the formula (III): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number ...

Productivity catalysts and microstructure control

Improved Group 3-11 transition metal based catalysts and processes for the polymerization of olefins are described. Some of the ligands are characterized by a preferred substitution pattern which allows for higher productivities of highly branched olefins; substitution patterns which boost productivity or alter the polymer microstructure are also described.

Method for manufacturing 3-amino-2-cyclohexene-1-one, and a novel polymer ingredient and its preparation

A method of manufacturing 3-amino-2-cyclohexene-1-one by hydrogenating m-phenylenediamene to produce a novel intermediate salt of 3-amino-2-cyclohexene-1-imine followed by hydrolysis to produce 3-amino-2-cyclohexene-1-one. The novel intermediate 3-amino-2-cyclohexene-1-imine has also be isolated.

PRODUCTION OF ISOTACTIC AND REGIORANDOM POLYPROPYLENE BASED POLYMER AND BLOCK COPOLYMERS

CATALYST SYSTEMS BASED ON AROMATIC DIAMINE LIGANDS

The present invention discloses the use of aromatic diamine ligands to prepare catalyst systems suitable for the oligomerisation or polymerisation of ethylene and alpha-olefins.

Способ получения симметричных дииминов на основе камфоры

Изобретение относится к способу получения азотсодержащих производных на основе камфоры, в частности к способу получения симметричных дииминов на основе камфоры, которые могут быть использованы в качестве ускорителей вулканизации для резиновых смесей на основе каучуков общего назначения. Способ заключается во взаимодействии камфоры с алифатическим диамином при кипячении в присутствии катализатора в среде толуола с азеотропной отгонкой воды. В качестве катализатора используют карбоксилат цинка при мольном соотношении камфора : диамин : карбоксилат цинка, равном 2,6:1:0,2. Технический результат: повышение выхода и уменьшение времени реакции. 5 пр.

Pro-fragrance & pro-flavorant compounds, by reacting alkene & carbonyl groups in fragrant & flavorant compounds with non-tert amines having 10 or more C-atoms

A pro-odorant or pro-flavorant that is liquid at room temperature and has a relatively low viscosity and has the formula (I): wherein R<1> is H, an aliphatic group or an aromatic group, R<2> is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R<1> and R<2> is 10 or more; R<5> is CN, COOH, COOR<7>, CHO or C(O)R<8>; R<3>, R<4> and R<6> are each independently hydrogen or organic moieties which together with R<5> render a compound of formula R<5>R<6>C=CR<3>R<4> a material having odorant or flavourant characteristics and R<7> and R<8> are each independently an organic moiety; or the formula (II) R<9>R<10>C=NR<11> wherein R<11> has at least 10 carbon atoms and is an aliphatic group or an aromatic group; R<9> and R<10> are each independently H or organic moieties which together with C=O render a compound of formula R<9>R<10>C=O a material having odorant or flavourant characteristics, provided ...

PROCESS FOR PRODUCING ss-HYDROXYAMINO ACID DERIVATIVE AND INTERMEDIATE THEREFOR

Reduction of hair growth

Small molecules for the modulation of MCL-1 and methods of modulatiing cell death, cell division, cell differentiation and methods of treating disorders

This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

PERFORMING AN ENZYME CATALYSED REACTION

MOISTURE-SCAVENGING IMINOALCOHOL-OXAZOLIDINE MIXTURES

IMINO COMPOUNDS AS PROTECTING AGENTS AGAINST ULTRAVIOLET RADIATIONS

The present invention relates to compounds having the general Formula I: which absorb UV radiations and protect biological materials as well as non-biological materials from damaging exposure to UV radiations. The present invention also relates to formulations and compositions comprising such compounds for use in absorbing UV radiations and in protecting biological materials as well as non-biological materials against UV radiations.

IMINO COMPOUNDS AS PROTECTING AGENTS AGAINST ULTRAVIOLET RADIATIONS

The present invention relates to compounds having the general Formula I: which absorb UV radiations and protect biological materials as well as non-biological materials from damaging exposure to UV radiations. The present invention also relates to formulations and compositions comprising such compounds for use in absorbing UV radiations and in protecting biological materials as well as non-biological materials against UV radiations.

MICHAEL ADDITION PRODUCT AND SCHIFF'S BASE AROMACHEMICALS

METHOD OF PREPARATION ENANTIOSELECTIVE Of ADDUITS OF PHENYLETHYLIMINO-CYCLOALCANES ALPHA SUBSTITUTE AND OF 2-ACETOXYACRYLONITRILE, INTERMEDIARIES IN SYNTHESIS ENANTOSELECTIVE OF the SIDE CHAIN OF the HARRINGTONINES

The invention relates to a method for the enantioselective preparation of adducts of alpha -substituted phenylethylimino-cycloalkanes and of 2-acetoxyacrylonitrile with the formula (I), wherein the carbon atom in position 1' has the stereochemistry 1'S or 1'R; n = 0 to 3; Z is a protected alcohol radical having the formula OGP<1>; GP<1> is a protective group such as a carbon-containing ether, a silylated ether or an ester; GP<2> is a protective group of enols such as a silylated ether; and involving a Michael reaction between the methyl cyanoacetate and a chiral imine.

Novel alkaline earth metal complexes and use thereof

The invention relates to novel chelate complexes of calcium, strontium and barium. The ligands that, together with the metal cation, form the complex are -ketiminate compounds having a scorpion tail structure. The invention also relates to the production of these compounds, to the use thereof, and to their intermediate products.

SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATIING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS

This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

ANTHRACEN DERIVATIVES AND THEIR USE FOR THE TREATMENT OF BENIGN AND MALIGNANT TUMOROUS DISEASES

The present invention provides anthracen derivatives according to the general formulas (I) and (II), as well as selected anthracen derivative compounds. Further, the present invention provides a method for the production of such anthracen derivatives. Further, pharmaceutical formulations containing these anthracen derivatives are provided. The anthracen derivatives provided are particularly suited to be used for the treatment or prophylaxis of physiological and/or pathophysiological conditions that can be treated by means of the inhibition of the tubulin polymerization, and/or by means of the inhibition of microtubuli-based motor proteins, particularly of diverse tumorous diseases.

Phenalenimine Fluorescent dyes and their use in analytical methods

Certain phenalenimine fluorescent compounds represented by the structure см. иллюстрацию в PDF-документе wherein R' and R" are independently hydrogen, alkyl, cycloalkyl, aryl or a heterocycle, or R' comprises the carbon and heteroatoms which forms a fused ring with the compound nucleus, are useful in biomedical and analytical determinations. These compounds can be used for staining cells, as well as for the determination of various analytes found in human or animal biological fluids. Such determination can be carried out in solution or by using dry analytical elements. The fluorescent compounds can be reacted with quinone nuclei to form reducible compounds which are also useful in analytical methods. In addition, the compounds can be incorporated into what are known as "loadable" latex particles to form detectable labels and biological reagents.

Process for the preparation of ramipril

An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided.

POLYMERIZATION PROCESSES FOR OLEFINS

Certain olefins such as ethylene, α-olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium α-diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or catalyst system containing certain nickel[II] or palladium[II] compounds, an α-diimine, a metal containing hydrocarbylation compound, and optimally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

Pro-fragrance and pro-flavorant compositions

Single-site catalysts based on caged diimide ligands

Michael addition product and Schiff's base aromachemicals

METHOD FOR PRODUCING MYCOSPORINE-LIKE AMINO ACID USING MICROBES

Prepolymer, prepolymer composition, high molecular weight polymer having hole structures and insulating membrane

This invention provides a prepolymer which is obtained by reacting compound A and compound B, each compound comprising at least 2 intermolecular functional groups or a group of functional groups, and the functional groups or a group of functional groups in one compound can bind to polymerization with the functional groups or a group of functional groups in another compound, resulting in forming a high molecular weight polymer having hole structure. The weight average molecular weight of the prepolymer is about 200 to 100000. In a preferred embodiment, the functional groups or a group of functional groups in compound A is carboxyl groups or amino groups, and the functional groups or a group of functional groups in compound B are two amino groups, amino group and hydroxyl group, amino group and mercapto group, or two carboxyl groups.

Alpha, beta-unsaturated imines

The present application relates to novel alpha, beta-unsaturated imines, to processes for their preparation, to their use for controlling animal pests including arthropods and in particular insects and to their use in the control of vectors. 2. The compound according to claim 1 , where Arepresents —C(R claim 1 ,R)—.3. The compound according to claim 1 , where Arepresents a —C(R claim 1 ,R)— group and where{'sup': 2', '3, 'said C(R,R)— group forms a double bond with the adjacent B position, or'}{'sup': 2', '3', '1', '2', '1', '2, 'sub': 'n', 'said C(R,R)— group is a bridging group which, together with a further bridging group and any B groups, located between these bridging groups, of the C(═C(W,X-Q)-C(═N-Q)-A-[B]-Aring and a corresponding bridge U forms an unsubstituted or substituted cyclic system, or'}{'sup': 2', '3, 'this said C(R,R)— group carries a substituent V.'}4. The compound according to claim 1 , where Ais part of a cyclic system.5. The compound according to claim 1 , where Ais part of a carbocyclic system comprising 6 ring atoms or part of a 5- or 6-membered heterocyclic system.6. The compound according to claim 5 , where Ais part of an aromatic system comprising 6 ring atoms or part of a 5- or 6-membered heteroaromatic system.7. The compound according to claim 1 , where n is 2.11. An insecticidal composition claim 1 , wherein said insecticidal composition comprises at least one compound according to claim 1 , and an extender and/or surfactant.12. A method for protecting transgenic and/or conventional seed and a plant generated therefrom against attack by pests claim 1 , comprising treating the seed with at least one compound according to .13. A compound according claim 1 , capable of being used for controlling pests.14. A compound according to claim 1 , capable of being used for controlling vectors.15. A seed in which a compound according to claim 1 , has been applied to said seed as a constituent of a casing and/or as a further layer and/or further ...

Catalytic system for preparation of high branched alkane from olefins

The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.

ANTI-TUMOR EFFECTS OF ALLOSTERIC FOCAL ADHESION KINASE INHIBITOR, METHYL VIOLET DERIVATIVES

Disclosed is a methyl violet derivative having inhibitory activity against allosteric focal adhesion kinase (FAK) and is useful as an agent for preventing or treating cancer. 2. The anti-cancer agent according to claim 1 , wherein each of R-Ris C-Calkyl claim 1 , Ris hydrogen or C-Calkyl and Xis a halide ion.5. The anti-cancer agent according to claim 1 , which exhibits inhibitory activity against focal adhesion kinase (FAK).6. The anti-cancer agent according to claim 1 , which is used to prevent and treat cancers selected from the group consisting of colorectal cancer claim 1 , rectal cancer claim 1 , skin cancer claim 1 , breast cancer claim 1 , lung cancer claim 1 , brain cancer claim 1 , prostate cancer claim 1 , lymphoma claim 1 , multiple myeloma and melanoma.7. The anti-cancer agent according to claim 2 , which exhibits inhibitory activity against focal adhesion kinase (FAK).8. The anti-cancer agent according to claim 3 , which exhibits inhibitory activity against focal adhesion kinase (FAK).9. The anti-cancer agent according to claim 4 , which exhibits inhibitory activity against focal adhesion kinase (FAK).10. The anti-cancer agent according to claim 2 , which is used to prevent and treat cancers selected from the group consisting of colorectal cancer claim 2 , rectal cancer claim 2 , skin cancer claim 2 , breast cancer claim 2 , lung cancer claim 2 , brain cancer claim 2 , prostate cancer claim 2 , lymphoma claim 2 , multiple myeloma and melanoma.11. The anti-cancer agent according to claim 3 , which is used to prevent and treat cancers selected from the group consisting of colorectal cancer claim 3 , rectal cancer claim 3 , skin cancer claim 3 , breast cancer claim 3 , lung cancer claim 3 , brain cancer claim 3 , prostate cancer claim 3 , lymphoma claim 3 , multiple myeloma and melanoma.12. The anti-cancer agent according to claim 4 , which is used to prevent and treat cancers selected from the group consisting of colorectal cancer claim 4 , rectal cancer ...

TOPICAL FORMULATIONS FOR UV PROTECTION

Novel compounds having a two-armed cyclic structure are described. These novel compounds absorb both ultraviolet (UV)-A and UV-B radiation and are formulated with pharmaceutically acceptable excipients to generate a topical composition which is photoprotective when applied to the skin of a subject. Methods for measuring the photoprotective properties of the novel compounds are described as are methods of protecting against sunburn or sun damage through the application of the topical compositions formulated as described. 1111-. (canceled)115. The compound of claim 112 , wherein Rand Rare the same.116. The compound of claim 113 , wherein Rand Rare the same.117. The compound of claim 114 , wherein Rand Rare the same.118. A topical composition claim 112 , comprising a compound of claim 112 , a chemical sunscreen claim 112 , a physical sunscreen claim 112 , a pharmaceutically acceptable carrier claim 112 , or a combination thereof.119. A topical composition claim 113 , comprising a compound of claim 113 , a chemical sunscreen claim 113 , a physical sunscreen claim 113 , a pharmaceutically acceptable carrier claim 113 , or a combination thereof.120. A topical composition claim 114 , comprising a compound of claim 114 , a chemical sunscreen claim 114 , a physical sunscreen claim 114 , a pharmaceutically acceptable carrier claim 114 , or a combination thereof.121. The topical composition of claim 118 , wherein the physical sunscreen comprising either zinc oxide or titanium oxide.122. The topical composition of claim 118 , further comprising an additional UV filter claim 118 , wherein the additional UV filter comprising:p-aminobenzoic acid, its salts and its derivatives (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic acid); anthranilates (o-aminobenzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl esters); salicylates (octyl, amyl, phenyl, benzyl, menthyl (homosalate), glyceryl, and dipropyleneglycol esters); cinnamic acid ...

Compositions, Methods of Use, and Methods of Treatment

Embodiments of the present disclosure provide compositions including ketamine analogues, salts, and disalts, pharmaceutical compositions including ketamine analogues, salts, or disalts, methods of treatment of a condition or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

IMINO COMPOUNDS AS PROTECTING AGENTS AGAINTS ULTRAVIOLET RADIATIONS

The present invention relates to compounds having the general Formula I: which absorb UV radiations and protect biological materials as well as non-biological materials from damaging exposure to UV radiations. The present invention also relates to formulations and compositions comprising such compounds for use in absorbing UV radiations and in protecting biological materials as well as non-biological materials against UV radiations. 196-. (canceled)98. The compound of claim 97 , wherein Ris selected from the group consisting of alkyl claim 97 , alkoxy claim 97 , and —CHCOOH.99. The compound of claim 97 , wherein X is selected from the group consisting of carbon claim 97 , nitrogen or oxygen.100. The compound of claim 97 , wherein Ris selected from the group consisting of alkoxy claim 97 , —OCH claim 97 , halogen claim 97 , fluorine claim 97 , alkanoyl claim 97 , —CONC(CH) claim 97 , amine claim 97 , and —N(CHCH).101. The compound of claim 97 , wherein n is 1.103. The compound of claim 102 , wherein:{'sub': '3', 'Ris selected from the group consisting of —CH3 and hydrogen;'}{'sub': 4', '3, 'Ris selected from the group consisting of —CHand hydrogen;'}{'sub': '5', 'Ris —COOH;'}Y is selected from the group consisting of O, S, and NH;{'sub': '6', 'Ris selected from the group consisting of hydrogen and —COOH; or'}n is 1.106. The compound of claim 105 , wherein:{'sub': '5', 'Ris selected from the group consisting of carboxyl and —COOH;'}Y is selected from the group consisting of S, O, and N;{'sub': '6', 'Ris hydrogen;'}X is selected from the group consisting of O and N; orn is 1.109. The compound of claim 108 , wherein:{'sub': '6', 'Ris hydrogen;'}{'sub': 7', '3, 'Ris selected from the group consisting of hydrogen, alkoxy, and —OCH;'}X is selected from the group consisting of N and O; orn is 1.112. The compound of claim 111 , wherein:{'sub': '3', 'Rand R4 are each independently selected from the group consisting of hydrogen and alkyl;'}{'sub': 3', '3, 'Ris —CH;'}{'sub': 4 ...

Azasteroidal Mimics

An azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic is formed via an oxocycloalkenyl isoxazolium anhydrobase and its dimer. The dimer can be used to form mono- and dihydrazones, which can be an azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic. A method of preparation of the dimer and the azasteroid mimic or an intermediate for the preparation of an azasteroid and azasteroid mimic occurs with hydrazonation and, optionally, a subsequent dehydrazonation. The dimer can be converted by inserting a nitrogen atom into the six membered ring of to a C-17 position cyclohexenone moiety of the dimer to yield a reduced tetrazolo[1,5-a]azepin-8-yl group. A subsequent hydrozone formation at a benzylic ketone can be carried out to generate an azasteroid mimic with a (triazol-4-yl)imino substituent. Monohydrazones can be converted to their thione equivalents.

PROCESS FOR THE PREPARATION OF RAMIPRIL

An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided. 5. The compound according to claim 4 , wherein the carbon atom bearing the R1 group has the (S) configuration.8. The compound of claim 7 , wherein the carbon atom bearing the COOR4 group has the (S) configuration.10. The compound of claim 9 , wherein the carbon atom bearing the CN group has the R-configuration.12. The compound according to any one of claim 9 , claim 9 , or claim 9 , whereinR1 in any one of the compounds of formulae (VI), (VI′) and (VII′) is COOR4.13. The compound according to any one of to claim 9 , whereinR2 in any one of the compounds of formulae (VI), (VI′), (VIIa), (VIIb) and (VII′) is methyl or ethyl.14. The compound according to any one of claim 9 , claim 9 , claim 9 , claim 9 , or claim 9 , whereinR3 in any one of the compounds of formulae (VI), (VIIa) and (VIIb) is methyl, ethyl, propyl, butyl, trifluoromethyl, methoxy, ethoxy, propoxy, butoxy, or phenyl.15. The compound according to any one of claim 9 , claim 9 , claim 9 , claim 9 , or claim 9 , whereinR4 in any one of the compounds of formulae (VI), (VI′), (VIIa) and (VII′) is methyl or ethyl.16. The compound according to any one of to claim 9 , wherein“Ar” in any one of the compounds of formulae (IVb), (VI) and (VI′) is phenyl, 4-methoxyphenyl, 4-chlorophenyl or naphtyl. The present invention relates to a new process for making Ramipril. The present invention further relates to an improved process for preparing (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid as an intermediate for manufacturing Ramipril. The present invention also relates to new intermediates and to a process for making them.Ramipril as shown in formula (I) is a known ACE inhibitor which is frequently employed in pharmacy to treat high blood pressure (hypertension), heart failure and related diseases.The production of Ramipril involves the coupling of the amino acid N-[1-( ...

METHOD FOR PRODUCING MYCOSPORINE-LIKE AMINO ACID USING MICROBES

Provided are: a method for producing a mycrosporine-like amino acid (MAA) that includes a step in which microbes are cultivated that produce MAA on the outside of bacterial cells, a step in which the bacterial cells and extracellular culture fluid are separated, and a step in which the MAA is recovered from the extracellular culture fluid; an MAA indicated by formula (1), an MAA produced using this method, or an ultraviolet-absorbing composition including the MAA indicated by formula (1); and a composition including the MAA produced using this method or the MAA indicated by formula (1), for preventing at least one symptom or disease selected from a group comprising acute skin reactions, aging of the skin, and skin cancer. 1. A method for producing a mycosporine-like amino acid , comprising:culturing a microorganism extracellularly producing the mycosporine-like amino acid,separating the microbial cell and extracellular culture solution, andrecovering the mycosporine-like amino acid from the extracellular culture solution.2. The method according to claim 1 , further comprising purifying the recovered mycosporine-like amino acid.3Escherichia coli. The method according to claim 1 , wherein the microorganism is a microorganism belonging to claim 1 , yeast claim 1 , actinomycetes claim 1 , microalgae or labyrinthulea.4. The method according to claim 3 , wherein the microorganism is an actinomycete.5StreptomycesActinosynnemaPseudonocardiaCorynebacterium.. The method according to claim 4 , wherein the actinomycete belongs to the genus claim 4 , the genus claim 4 , the genus or the genus6Aurantiochytrium.. The method according to claim 3 , wherein the microorganism is labyrinthulea and belongs to the genus7Saccharomyces.. The method according to claim 3 , wherein the microorganism is yeast and belongs to the genus8. The method according to claim 1 , wherein the microorganism comprises heterologous mycosporine-like amino acid biosynthetic enzyme genes.9Actinosynnema mirum.. ...

Compounds for Modulating Integrin CD11B/CD18

The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.

SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS

This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients. 136-. (canceled)38. The compound of claim 37 , wherein n is 0.39. The compound of claim 37 , wherein q is 0.40. The compound of claim 37 , wherein X is ═O.41. The compound of claim 37 , wherein Ris —SO—R claim 37 , in which Ris substituted aryl.42. The compound of claim 41 , wherein Ris 4-methylphenyl.43. The compound of claim 37 , wherein Ris —S—Rin which Ris unsubstituted heteroaryl.44. The compound of claim 43 , wherein Ris 1 claim 43 ,2 claim 43 ,4-triazolyl.46. A pharmaceutical composition comprising the compound of or a physiologically acceptable salt claim 37 , solvate claim 37 , hydrate or stereoisomer thereof and a pharmaceutically acceptable diluent or carrier.47. A method of selectively modulating MCL-1 in a cell claim 37 , comprising contacting the cell with one or more compounds of claim 37 , thereby regulating MCL-1 in the cell.48. A method for modulating apoptotic cell death in a cell claim 37 , comprising contacting the cell with one or more compounds of claim 37 , thereby regulating apoptotic cell death in the cell.49. A method for modulating autophagy in a cell claim 37 , comprising contacting the cell with one or more compounds of claim 37 , thereby regulating autophagy in the cell.50. A method for modulating necrotic cell death in a cell claim 37 , comprising contacting the cell with one or more compounds of claim 37 , thereby regulating necrotic cell death in the cell.51. A method for ...

COMPOUNDS AND MIXTURES WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND COMPOSITIONS INLUDING SUCH COMPOUNDS

Antidegradant compounds are disclosed, and methods of making them, that are represented by the formula I: 2. The compound of claim 1 , wherein each X is hydrogen.3. The compound of claim 1 , wherein each X is methyl.5. The method of claim 4 , wherein the p-phenylenediamine is reacted with the dicarbonyl in the presence of an acid catalyst.7. The method of claim 6 , wherein the p-phenylenediamine is reacted with the dicarbonyl in the presence of an acid catalyst.9. The method of claim 8 , wherein the p-phenylenediamine is reacted with the diol or the dicarbonyl in the presence of an acid catalyst. This continuation-in part application claims the priority benefit of U.S. Nonprovisional patent application Ser. No. 15/371,257 filed Dec. 7, 2016, which in turn claims priority to Provisional Patent Application Ser. No. 62/270,909, titled “COMPOUNDS WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND COMPOSITIONS INCLUDING SAID COMPOUNDS,” filed Dec. 22, 2015, the entire disclosures of which are incorporated herein by reference.The present invention relates generally to compounds, and methods of making them, that have antidegradant and antifatigue efficacy and are useful as an additive for vulcanized rubber articles, vulcanizable elastomeric formulations, lubricants, fuels, fuel additives and other compositions which require such efficacy or in compositions which are themselves useful as compositions to impart such efficacy.Many materials such as plastics, elastomers, lubricants, cosmetics and petroleum products (such as hydraulic fluids, oils, fuels and oil/fuel additives for automotive and aviation applications) are prone to degradation upon prolonged exposure to light, heat, oxygen, ozone, repetitive mechanical actions and the like. Accordingly, compounds and compositions demonstrating antidegradant efficacy are well known the art. For example, U.S. Pat. No. 8,987,515 discloses an aromatic polyamine useful in inhibiting oxidative degradation particularly in lubricant ...

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Olefin polymerization processes using supported catalysts

Improved Group 8-10 transition metal based supported catalyst processes for the polymerization of olefins are described. Some of the improvements pertain to protocols for catalyst preparation and activation which improve the catalyst productivity in the presence of hydrogen as a molecular weight control agent.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Single-site catalysts based on caged diimide ligands

Single-site catalysts useful for polymerizing olefins are disclosed. The organometallic catalysts incorporate a Group 3 to 10 transition, lanthanide or actinide metal and a caged diimide ligand. The diimide ligands are made by a tandem Diels-Alder and photochemical [2+2] cycloaddition sequence to give a multicyclic dione, followed by condensation with a primary amine. Because a wide variety of caged diimide ligands are easy to prepare from commercially available dienes and dienophiles, the invention enables the preparation of a new family of single-site catalysts. Based on their unique structure and geometry, the catalysts offer polyolefin producers new ways to improve activity, control comonomer incorporation, or regulate polyolefin tacticity.

Productivity catalysts and microstructure control

Improved Group 3-11 transition-metal based catalysts and processes for the polymerization of olefins are described. Some of the ligands are characterized by a preferred substitution pattern which allows for higher productivities of highly branched olefins; substitution patterns which boost productivity or alter the polymer microstructure are also described.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromafic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Polymerization processes for olefins

Certain olefins such as ethylene, α-olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium α-diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or catalyst system containing certain nickel[II] or palladium[II] compounds, an α-diimine, a metal containing hydrocarbylation compound, and optimally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

Catalysts containing n-pyrrolyl substituted nitrogen donors

Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or oligomerization of olefins using the catalyst compositions.

Catalytic system for preparation of high branched alkane from olefins

Production of isotactic and regiorandom polypropylene based polymer and block copolymers

One step ortho-alkylation of anilines with styrenes to give chiral anilines is obtained using a strong acid catalyst, e.g. CF 3 SO 3 H. Condensation of the product to give ligand and metallation gives complex which catalyzes polymerization of propylene to give isotactic propylene or regiorandom propylene of low PDI or blocks thereof, depending on polymerization temperature.

Polymerization processes for olefins

Certain olefins such as ethylene, α-olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium α-diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or a catalyst system containing certain nickel II! or palladium II! compounds, an α-diimine, a metal containing hydrocarbylation compound, and optionally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

Catalysts containing n-pyrrolyl substituted nitrogen donors

Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or oligomerization of olefins using the catalyst compositions.

Catalytic system for preparation of high branched alkane from olefins

The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.

Catalytic system for preparation of high branched alkane from olefins

The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.

POLYMERIZATION PROCESS FOR OLEFINES

Polymerization processes for olefins

Certain olefins such as ethylene, α-olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium α-diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or catalyst system containing certain nickel[II] or palladium[II] compounds, an α-diimine, a metal containing hydrocarbylation compound, and optimally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

Polimerization Processes for Olefins

에틸렌, α-올레핀 및 시클로펜텐과 같은 특정 올레핀은 니켈 또는 팔라듐 α-디이민 복합체, 금속을 함유하는 히드로카빌화 화합물, 및 선택된 루이스 산으로 구성된 촉매계, 또는 특정 니켈(II) 또는 팔라듐(II) 화합물들, α-디이민, 금속을 함유하는 히드로카빌화 화합물, 및 임의로 선택된 루이스 산으로 구성된 촉매계를 이용하여 중합될 수 있다. 본 방법은 주물 수지, 필름, 탄성 중합체, 및 기타의 용도에 유용한 폴리올레핀을 용이하게 생산한다. Certain olefins, such as ethylene, α-olefins and cyclopentene, are catalyst systems consisting of nickel or palladium α-diimine complexes, hydrocarbylated compounds containing metals, and selected Lewis acids, or specific nickel (II) or palladium (II) It can be polymerized using a catalyst system consisting of compounds, α-diimine, hydrocarbylated compounds containing metal, and optionally selected Lewis acids. The method readily produces polyolefins useful for casting resins, films, elastomers, and other applications.

烯烃聚合法

某些烯烃例如乙烯、α－烯烃和环烯烃能够通过使用包含镍或钯α－二亚胺配合物、一种含金属的烃基化反应化合物、和被选择的路易斯酸的催化剂体系,或包含镍[Ⅱ]或把[Ⅱ]化合物、一种α－二亚胺、一种含金属的烃基化反应化合物、和非强制有的路易斯酸的催化剂体系而被聚合。该方法有利地生产出用于模塑树脂、薄膜、弹性体和其他用途。

Polymerization processes for olefins

Certain olefins such as ethylene, alpha -olefins and cyclopentene can be polymerized by using catalyst system containing a nickel or palladium alpha -diimine complex, a metal containing hydrocarbylation compound, and a selected Lewis acid, or a catalyst system containing certain nickel[II] or palladium[II] compounds, an alpha -diimine, a metal containing hydrocarbylation compound, and optionally a selected Lewis acid. The process advantageously produces polyolefins useful for molding resins, films, elastomers and other uses.

Processo para a polimerização de olefinas e composto.

<B>"PROCESSO PARA A POLIMERIZAçãO DE OLEFINAS E COMPOSTO"<D>. A presente invenção refere-se a determinadas olefinas, tais como etileno, alfa-olefinas e ciclopenteno, que podem ser polimerizadas mediante o emprego de um sistema catalisador contendo um complexo de níquel ou paládio alfa-diimina, um composto de hidrocarbilação contendo metal e um ácido de Lewis selecionado, ou um sistema catalisador contendo determinados compostos de níquel [II] ou paládio [II], alfa-diimina, um composto de hidrocarbilação contendo metal, e opcionalmente um ácido de Lewis selecionado. O processo produz vantajosamente poliolefinas úteis para a moldagem de resinas, películas, elastómeros e outros usos.

METHOD OF POLYMERIZATION OF OLEFINS

Некоторые олефины, такие как этилен, α-олефины и циклопентен, могут полимеризоваться с использованием каталитической системы, содержащей никелевый или палладиевый α-дииминовый комплекс, металлсодержащее гидрокарбилирующее соединение и выбранную кислоту Льюиса, или каталитической системы, содержащей некоторые соединения никеля (II) или палладия (II), α-диимин, металлсодержащее гидрокарбилирующее соединение и, в оптимальном варианте, выбранную кислоту Льюиса. Такой способ позволяет успешно получать полиолефины, используемые в качестве формовочных смол, пленок, эластомеров и находящие другие применения.Международная заявка была опубликована вместе с отчетом о международном поиске. Some olefins, such as ethylene, α-olefins and cyclopentene, can be polymerized using a catalytic system containing a nickel or palladium α-diimine complex, a metal-containing hydrocarbyl compound and a selected Lewis acid, or a catalytic system containing some nickel (II) or palladium compounds (Ii) α-diimine, a metal-containing hydrocarbyl compound, and, optimally, a selected Lewis acid. This method allows you to successfully obtain polyolefins used as molding resins, films, elastomers and other applications. The international application was published together with an international search report.

Separation of unsymmetrical diimines by liquid chromatography

Novel unsymmetrical diimines containing a polar group are made by preparing a mixture of the unsymmetrical diimine and two symmetrical diimines, for example by reacting a dicarbonyl compound with two primary amines. The unsymmetrical diimine is then purified by liquid chromatography. The unsymmetrical diimines are useful as ligands in olefin polymerization catalysts.

不对称α二亚胺镍配合物催化剂及其制备方法与应用

本发明公开了不对称α二亚胺镍配合物催化剂及其制备方法与应用。该配合物如式I所示，R 1 为二苯甲基，R 2 为甲基或二苯甲基，R 3 为甲基、乙基、异丙基、二苯甲基或卤素，R 4 为碳原子总数为1-3的烷基，R 5 为氢或碳原子总数为1-3的烷基，X为氯或溴。制备方法为：在无氧条件下，配体与(DME)NiBr 2 或NiCl 2 ·4H 2 O反应，得到产物。本发明合成了含有不对称α二亚胺配体以及镍金属配合物，该配合物在助催化剂氯化二乙基铝、甲基铝氧烷或改性甲基铝氧烷作用下，能够较好的催化乙烯聚合，得到高分子量的聚合物，同时其活性也很高，最高活性可以10 7 g·mol -1 (M)·h -1 ；具有广泛的工业应用前景。

Catalytic system for preparation of high branched alkane from olefins

An α-diimine metal complex catalyst, wherein the metal may be nickel or palladium. The catalyst may be used for direct catalytic polymerization of olefins to provide the olefin polymer, further preparing the highly branched alkane mixtures as oil. The alkane mixtures may be used for preparation of the lubricating oils. Provided also are the method for preparation of the catalyst and uses of the oily olefin polymer.

Catalysts containing per-ortho aryl substituted aryl or heteroaryl substituted nitrogen donors

Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms independently substituted by an aromatic or heteroaromatic ring(s), wherein the ortho positions of said ring(s) are substituted by aryl or heteroaryl groups. Also disclosed are processes for the polymerization of olefins using the catalyst compositions.

Catalysts containing n-pyrrolyl substituted nitrogen donors

Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N- pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or oligomerization of olefins using the catalyst compositions .

胺基亚胺配体、胺基亚胺配合物及其应用

本发明公开了一种胺基亚胺配体，其具有式Ⅰ所示的结构， R 1 ‑R 4 各自独立地选自H、卤素、C 1 ‑C 30 饱和或不饱和的烃基和取代的C 1 ‑C 30 饱和或不饱和的烃基，R 1 ‑R 4 任选地相互成环；R 5 选自H和C 1 ‑C 20 饱和或不饱和的烃基；R 9 ‑R 10 各自独立地选自饱和或不饱和的烃基和取代的饱和或不饱和的烃基。由该胺基亚胺配体形成的配合物应用于烯烃聚合具有高的催化活性，得到的产物的分子量分布窄。

一种带有羟基的芳香胺及其α-二亚胺配合物和在烯烃聚合中的应用

本发明为一种带有羟基的芳香胺及其α‑二亚胺配合物和在烯烃聚合中的应用。所述带有羟基的芳香胺的结构式如下式I：其中，X为CH 2 或OCH 2 CH 2 ；Ar为有取代基的或未取代的C 6 ‑C 60 芳烃基、C 3 ‑C 60 的杂环芳烃基中的一种；n＝0‑30之间的任一自然数。该芳香胺带有羟基以及大的位阻基团。该带有羟基的胺的制备过程比较简单，它们以及基于它们的α‑二亚胺催化剂的制备成本很低，有利于实现产业化的推广。

一类二(苯基)甲基取代的氟代苯基苊二亚胺镍配合物制备方法与乙烯聚合

本发明公开一种二(苯基)甲基取代的氟代苯基苊二亚胺镍配合物催化剂的制备方法及其应用。该配合物的结构式如式I所示，本发明的二(苯基)甲基取代的氟代苯基苊二亚胺镍配合物在助催化剂甲基铝氧烷、改性甲基铝氧烷或氯化二乙基铝作用下，能够高活性地催化乙烯聚合，得到高分子量聚合物，最高活性达10 7 g·mol –1 (Ni)·h –1 ，最高分子量(M w )达10 6 g·mol –1 。具有很好的工业应用前景。

Ｎ−ピロリル置換窒素ドナーを含む触媒

(57)【要約】 オレフィンの重合またはオリゴマー化に有用な触媒組成物が開示される。この触媒組成物の一部は、Ｎ−ピロリル置換窒素ドナーを含む。また、この触媒組成物を用いたオレフィンの重合またはオリゴマー化方法も開示される。

Compounds and mixtures having antidegradants and antifatigue efficacy and compositions comprising such compounds

本发明公开了由式(I)表示的抗降解剂化合物及其制备方法： ，其中每个X独立地选自乙基、甲基或氢。还公开了对应于式(III)的二亚胺中间体：

Overlapped steric hindrance-enhanced alpha-diimine ligand, nickel catalyst, preparation method and application thereof

本发明提供一类叠加大位阻α‑二亚胺配体、镍催化剂及其制备方法和应用。属于催化剂领域。该配体的结构如式(I)所示。本发明还提供一类叠加大位阻α‑二亚胺配体的制备方法。本发明还提供一种镍催化剂，结构如式(II)所示。本发明还提供一种镍催化剂的制备方法。该类镍催化剂在一定条件下，催化乙烯聚合活性可高达1026.0×10 6 g mol ‑1 h ‑1 ，且可得到超高分子量，支化度可调的聚乙烯。此外，在110～150℃高温下，该类催化剂仍然具有相当高的催化活性。其中，超高分子量低支化度聚乙烯具有良好的工业应用前景，在一定程度上可考虑作为超高分子量聚乙烯纤维使用。

Production of isotactic and regiorandom polypropylene based polymer and block copolymers

One step ortho-alkylation of anilines with styrenes to give chiral anilines is obtained using a strong acid catalyst, e.g. CF 3 SO 3 H. Condensation of the product to give ligand and metallation gives complex which catalyzes polymerization of propylene to give isotactic propylene or regiorandom propylene of low PDI or blocks thereof, depending on polymerization temperature.

Large steric hindrance alpha-diimine ligand, nickel catalyst, preparation method and application thereof

本发明涉及一类大位阻α‑二亚胺配体、镍催化剂及其制备方法与应用，属于催化剂技术领域。解决了现有技术中α‑二亚胺催化剂存在的两点问题：1)得到的共聚物分子量很低，一般在一万以下；2)条件比较苛刻，通常需要高温高压。本发明的镍催化剂，结构式如式(II)所示。该镍催化剂具有超大的轴向空间位阻，能够有效地抑制链转移，具有高活性的优点(高达6.9×10 7 gmol ‑1 h ‑1 )，并且在高温下仍然能保持高活性，还具备优异的热稳定性，在常温常压下即可制备得到超高分子量功能化聚烯烃材料。

Large steric hindrance alpha-diimine ligand, nickel catalyst, preparation method and application thereof

本发明涉及一类大位阻α‑二亚胺配体、镍催化剂及其制备方法与应用，属于催化剂技术领域。解决了现有技术中α‑二亚胺催化剂存在的两点问题：1)得到的共聚物分子量很低，一般在一万以下；2)条件比较苛刻，通常需要高温高压。本发明的镍催化剂，结构式如式(II)所示。该镍催化剂具有超大的轴向空间位阻，能够有效地抑制链转移，具有高活性的优点(高达6.9×10 7 gmol ‑1 h ‑1 )，并且在高温下仍然能保持高活性，还具备优异的热稳定性，在常温常压下即可制备得到超高分子量功能化聚烯烃材料。

Catalysts containing N-pyrrolyl substituted nitrogen donors

Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or oligomerization of olefins using the catalyst compositions.

Alpha,beta-unsaturated imines

The invention relates to novel alpha,beta-unsaturated imines, to a method for producing same, to the use thereof for combating animal pests, including anthropods and in particular insects, and to the use thereof in vector control.

Alpha, beta-unsaturated imines

The present application relates to novel alpha, beta-unsaturated imines, to processes for their preparation, to their use for controlling animal pests including arthropods and in particular insects and to their use in the control of vectors.

Compound, colorant composition comprising the same and resin composition comprising the same

본 명세서는 신규한 화합물, 이를 포함하는 색재 조성물 및 이를 포함하는 수지 조성물에 관한 것이다. The present specification relates to a novel compound, a colorant composition comprising the same, and a resin composition comprising the same.

A kind of big steric hindrance α diimine compounds of acenaphthenyl skeleton and its synthetic method

本发明属于化合物合成领域，具体涉及一种苊基骨架大位阻α‑二亚胺化合物及其合成方法，该化合物结构式如式（Ⅰ）所示： ，本发明提供的合成苊基骨架大位阻α‑二亚胺化合物的方法具有较好的底物普适性；产率高，且分离容易，具有很好的工业化价值。利用本申请提供的合成方法，可以合成一系列新型的苊基骨架大位阻α‑二亚胺化合物。

N-(substituted benzyloxy)imine derivatives, process for the production thereof, use thereof, and method of use thereof

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N-(substituted benzyloxy)imine derivatives, process for the production thereof, use thereof, and method of use thereof

Compound of the general formula (I), which is useful as an agricultural and horticultural fungicide, an agricultural and horticultural fungicidal composition containing said compound, use of said composition for controlling plant disease, and process for the production of said compound: shows a case in which R 3 and R 4 together form a cyclic substituent, and R 1 to R 4 are substituents disclosed in the specification.

Method of preparing (S)-2-amino-5-methoxytetralin hydrochloride

A method of preparing (S)-2-amino-5-methoxytetralin hydrochloride[(S)-2-amino-5-methoxyl-1,2,3,4-tetrahydronaphthalene hydrochloride], comprising the steps of: (1) producing a compound (I) by addition-elimination reaction of 5-methoxy-2-tetralone and R-(+)-a-phenylethylamine; (2) producing a compound (II) by reduction reaction of the compound (I) with a reducing agent; and (3) producing a compound (II) hydrochloride by reacting the compound (II) with a salt-forming agent, then carrying out reduction reaction with a palladium-carbon catalyst to produce (S)-2-amino-5-methoxytetralin hydrochloride. The method can significantly increase the yield of (S)-2-amino-5-methoxytetralin hydrochloride with short synthetic path, low preparation cost and less pollution, which is environmentally friendly and is suitable for medical industrialized production. The structural formulae of the compound (I) and the compound (II) are: respectively.

Compounds for organic photovoltaic devices

Process for the preparation of an imine intermediate

The invention is directed to a process for the preparation of [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1-ylidene]-methyl-amine of the Formula (I) by reacting 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalene-l-one of the Formula (II) with monomethyl amine which comprises carrying out the reaction in the presence of thionyl chloride in an ether-type solvent. The [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1-ylidene]-methyl-amine of the Formula I is a valuable pharmaceutical intermediate.

NOVEL AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES.

Nouveaux dérivés racémiques ou actifs du point de vue optique d'aminopropanol répondant à la formule (CF DESSIN DANS BOPI) où R et R1 sont un atome d'hydrogène, un atome d'un halogène, un alcoxy inférieur, ou sont tous deux un groupe méthylène dioxy, R2 et R3 représentent tous deux une liaison chimique ou chacun un atome d'hydrogène, R4 et R5 sont un atome d'hydrogène, un groupe cycloalkyle C3 -7 ou un groupe alkyle C1 -12 linéaire ou ramifié, saturé ou insaturé, remplacé facultativement par un ou des groupes dialkyle-aminoalkyle, diméthoxyphényle ou phényle, R6 est un atome d'hydrogène ou un groupe benzoyle, et n un entier entre 3 et 6, sels formés par addition d'acides et dérivés d'ammonium quaternaire de ces produits. Application notamment aux produits améliorant la circulation cardiaque et/ou tranquillisant le système nerveux central.

Chelating agents and their manganic chelates

Chelating agents (chelants) of general structure: (I), or (II) wherein: n = 2-4, X = -CR1R2-, or whereby at least two of X are of formula (III); Y = COOH, -PO3H2 or o-hydroxyphenyl; R1, R2 or R3 are independently H or C1-C8alkyls; m = 1, 2 or 3 and most preferably m = 1; Z and Z1 are unsubstituted or substituted C; C+ = C or CH or N; Z¿1?, Z2, Z'1 and Z'2 are independently selected from H (or nothing for Z2 and Z'2 if C* is N) and C1-C10 groups that optionally contain one or more N atoms (optionally attached directly to C*), whereby one of the pairs Z/Z1, Z/Z2 and Z1/Z2 and one of the pairs Z'/Z'1, Z'/Z'2 and Z'1/Z'2 may be connected to form substituted or unsubstituted (hetero)(poly)cyclic structures of less than 20 atoms; C* is either part of an aromatic (hetero)(poly)cyclic structure or linked by a double bond to Z or Z2 and/or Z' or Z'2.

Method of obraining novel aminopropanel derivatives

Racemic or optically active aminopropanol derivatives of formula I <IMAGE> wherein R and R<1> are hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene @@@@@@@dioxy group, R<2> and R<3> together represent a chemical bond or independently stand for a hydrogen atom, R<4> and R<5> are independently hydrogen atom, C3-7 cycloalkyl group or @@@@@@@saturated or unsaturated C1-12 @@@@@@@alkyl group optionally substituted by one @@@@@@@or more dialkylaminoalkyl, @@@@@@@dimethoxyphenyl or phenyl groups, or R<4> and R<5> together with the adjacents nitrogen atom form a 4 to 7 membered ring optionally @@@@@@@comprising an oxygen sulfur, or a further @@@@@@@nitrogen atom, which ring is optionally @@@@@@@substituted by a phenyl, @@@@@@@benzyl or C1-3 alkyl group and @@@@@@@the said substituents may carry a hydroxyl @@@@@@@group, one or two methoxy groups, halogen @@@@@@@atoms or trifluoro-methyl groups, or R<4> and R<5> together with the adjacent nitrogen atom form a piperidine ring which is optionally @@@@@@@substituted by a phenyl or benzyl group @@@@@@@and, if desired, it comprises a double @@@@@@@bond, R<6> stands for hydrogen atom or benzoyl group, and n represents an integer from 3 to 6, acid-addition salts and quaternary ammonium derivates thereof, exert cardiac circulation controlling and/or improving, central nervous system tranquilizing and/or digestive system irregulations improving effects.

Pro-fragrance and pro-flavorant compositions

A pro-odorant or pro-flavorant that is liquid at room temperature and has a relatively low viscosity and has the formula (I): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; R5 is CN, COOH, COOR7, CHO or C(O)R8; R3, R4 and R6 are each independently hydrogen or organic moieties which together with R5 render a compound of formula R5R6C=CR3R4 a material having odorant or flavourant characteristics and R7 and R8 are each independently an organic moiety; or the formula (II): R9R10C=NR11 wherein R11 has at least 10 carbon atoms and is an aliphatic group or an aromatic group; R9 and R10 are each independently H or organic moieties which together with C=O render a compound of formula : R9R10C=O a material having odorant or flavourant characteristics, provided that only one of R9 and R10 is hydrogen; or the formula (III): wherein R1 is H, an aliphatic group or an aromatic group, R2 is an aliphatic group or an aromatic group, provided that the total number of carbon atoms in the groups R1 and R2 is 10 or more; Z is CH2 or O, n is 0 or 1, such that the ring is a 5 or 6 membered ring, R12 is H, alkyl or alkenyl or alkoxy having up to 10 carbon atoms so as to render a compound of formula (V): a material having odorant or flavorant characteristics; or formula (IV): wherein R11 has at least 10 carbon atoms and is an aliphatic group or an aromatic group; the or each R13 is independently a straight or branched chain, saturated or unsaturated hydrocarbyl group or alkoxy group having from 1 to 8 carbon atoms or two groups R13 together with the carbon atoms to which they are attached form a five or six membered ring which may be saturated or unsaturated (including aromatic) and which may be optionally substituted with from 1 to 3 alkyl groups having from 1 to 6 carbon atoms; and x is from 1 to 5 so as to render a compound of formula (VI): a ...

Alpha, beta-unsaturated imines

Ethenylidene acenaphthene alpha-diimine nickel alkene catalyst and its preparation method and application

本发明公开了一种基于亚乙烯基苊醌为骨架的大位阻不对称(α‑二亚胺)镍烯烃催化剂及其制备方法和应用。本发明的基于亚乙烯基苊醌为骨架的大位阻不对称(α‑二亚胺)镍烯烃催化剂的结构式如式(Ⅰ)所示。其中R 1 为二苯甲基或双(4‑氟苯基)甲基，R 2 为二苯甲基、双(4‑氟苯基)甲基或甲基，R 3 为甲基、乙基、异丙基、二苯甲基、双(4‑氟苯基)甲基、卤素、三氟甲基或甲氧基，R 4 为甲基、乙基或异丙基，R 5 为甲基、乙基或异丙基，R 6 为氢、甲基、乙基或异丙基，X为氯或溴。该催化剂制备工艺简单，能在助催化剂的作用下催化乙烯聚合，表现出较好的热稳定性和聚合活性，具有良好的工业应用前景。

N-phenyl-s,2,6,6-tetrahalocyclo hexaneimine and process for preparing 2,2,6,6-tetrahalocyclohexaneimine derivative and 2,6-dihaloaniline derivative

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Composition containing oxocarbon and use thereof

Use of natural vegetable components as flavouring agents in the coating of chewing gum

The present invention relates to the use of natural vegetable flavouring components as flavouring agents in chewing gum coating. The addition of a natural vegetable component to a chewing gum coating results in increased flavour sensation. The invention also relates to a method for the preparation of a chewing gum wherein the coating comprises a natural vegetable component as flavouring agent. The chewing gum comprises a) an insoluble gum base; b) a water soluble portion; c) a coating comprising a flavouring agent wherein at least 10% by weight of the flavouring agent is a natural vegetable flavouring agent.

PROCESS FOR THE PREPARATION OF N-OE4- (3,4-DICHLORPHENYL) -3,4-DIHYDRO-1 (2H) NAPHTHALENYLIDENAMETHANAMINE

NEW AMINOPROPANOL DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Prepolymer, prepolymer composition, high molecular weight polymer having structure containing hole and electrically insulating film

A prepolymer, characterized in that it is prepared by the reaction of two compounds A and B which have two or more functional moieties or two or more groups of functional moieties, respectively, and are capable of undergoing a polymerization through the bonding of a functional moiety or a group of functional moieties of one compound with a functional moiety or a group of functional moieties of the other compound to form a high molecular weight polymer having a structure containing a hole. The prepolymer has a weight average molecular weight of ca. 200 to 100000. In a preferred embodiment, the compound A has a carboxyl moiety or an amino moiety as the above functional moiety or a group of functional moieties, and the compound B has two amino moieties, an amino moiety and a hydroxyl moiety, an amino moiety and a mercapto moiety, or two carboxyl moieties as the above functional moiety or a group of functional moieties.

Method for decarboxylation of amino acids via imine formation

The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under pressurized and superheated conditions in either a microwave or oil bath.

Process for preparing a ketimine

P.C. (Ph) 7371 IMPROVED PROCESS FOR PREPARING A KETIMINE Abstract An improved condensation process for preparing N-[4-(3,4-dichlorophenvl)-3,4-dihydro-1(2H)-naphtha-lenylidene]methanamine from 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone and methylamine is disclosed. The process involves the use of a hydratable molecular sieve having a pore size that is at least about three Angstrom units in diameter as the dehydrating agent (catalyst) in a reaction-inert aprotic organic solvent. The ketimine final product so produced is known to be useful as an intermediate leading to cis-(1S)(4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (sertraline), which is an anti-depressant agent.

Urolithin a and derivatives thereof for use in therapy

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Cyclic ketone derivatives and pharmaceutical compositions containing same as well as a process for their preparation

NOVEL AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME A B S T R A C T The invention relates to novel racemic or optically active aminopropanol derivatives of formula I I wherein R and R1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group, R2 and R3 together represent a chemical bond or independently stand for a hydrogen atom, R4 and R5 are independently hydrogen atom, C3-7 cycloalkyl group or straight or branched, saturated or unsaturated C1-12 alkyl group optionally substituted by one or more dialkyl--aminoalkyl, dimethoxyphenyl or phenyl groups, or R4 and R5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoro-methyl groups, or R4 and R5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a phenyl or benzyl group and, if desired, it comprises a double bond, R6 stands for hydrogen atom or benzoyl group, and n represents an integer from 3 to 6, acid-addition salts and quaternary ammonium derivatives thereof. Further the invention relates to processes for preparing these compounds. The compounds of the invention exert cardiac circulation controlling and/or improving, central nervous system tranquillizing and/or digestive system irregulations improving effects.

Cyclopentadiene derivative compounds and electrophotographic photoconductor comprising one cyclopentadiene derivative compound

Cycolpentadiene derivative compounds, and an electrophotographic photoconductor comprising one cyclopentadiene derivative compound are disclosed. The cyclopentadiene derivative compounds are novel and useful for use in a photoconductive layer, and readily soluble in a binder resin. The electrophotographic photoconductor can be prepared by using a simple, effective production method. The electrophotographic photoconductor comprising one cyclopentadiene derivative compound provides a good light sensitivity and high durability.

Method for producing mycosporine-like amino acid using microbes

本发明提供：生产类菌孢素氨基酸(MAA)的方法，所述方法包括：培养在菌体外产生MAA的微生物的步骤、将菌体与菌体外培养液分离的步骤和从菌体外培养液回收MAA的步骤；由下述式1表示的MAA；通过本发明的方法生产的MAA；或包含由下述式1表示的MAA的紫外线吸收用组合物；以及，用于预防选自急性皮肤反应、皮肤老化和皮肤癌的一种以上的症状或疾病的、包含通过本发明的方法生产的MAA或由下述式1表示的MAA的组合物。 (1)。

α -diimine compound capable of forming double hydrogen bonds, metal complex containing compound, load and application of load

本发明为一种能形成双氢键的α‑二亚胺化合物和包含该化合物的金属配合物、负载物以及其应用。该α‑二亚胺化合物，连接在苊环的取代基上的两个羟基或氨基可以使α‑二亚胺化合物与载体可以形成两个氢键作用，从而表现出更大的相互作用，牢牢地负载在载体上；可以进一步得到含有该α‑二亚胺化合物的金属配合物，及含有该α‑二亚胺化合物的金属配合物的负载物。该负载型α‑二亚胺金属配合物的负载方式简便，所述的负载型α‑二亚胺金属配合物作为主催化剂用于烯烃的聚合中，可以克服粘釜、聚合物形态难以控制、助催化剂用量多、热稳定性差等不足。

Process for production of bicyclo[2.2.2]octylamine derivative

本发明提供可作为药品制造中间体的二环[2.2.2]辛胺衍生物的有效的、并且能够利用温和条件大量合成的制造方法。通过使通式(1)所示的化合物和通式(2)：R 2 -NH 2 (2)环化，并进行还原，制造二环[2.2.2]辛胺衍生物。通式(1)中，R 1 表示可具有取代基的碳原子数1～6的烷基、可具有取代基的芳甲基、或可具有取代基的芳乙基。通式(2)中，R 2 表示可具有取代基的碳原子数1～6的烷基、可具有取代基的芳烷基、羟基、可具有取代基的碳原子数1～6的烷氧基、或可具有取代基的芳烷氧基。

Urolithin A and derivatives thereof for use in therapy

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Electronic device and compound

The invention relates to an electronic device comprising a compound having Formula (1): AB X (1), wherein A is a structural moiety that consists of at least two atoms and comprises a conjugated system of delocalized electrons, each B is independently selected from an imine functional group (la), wherein R 1 , R 2 , R 3 , R 4 are independently selected from C 1 -C 30 alkyl, C 2 -C 30 alkenyl, C 2 -C 3 alkinyl, C 3 -C 30 cycloalkyl, C 6 -C 30 aryl, C 2 -C 30 heteroaryl, C 7 -C 30 arylalkyl, C 3 -C 30 heteroarylalkyl, the wave line represents a covalent bond to the imine nitrogen atom, G is in each group (la) independently selected from a quarternary carbon atom and from a cyclopropenylidene structural moiety, x is an integer equal one or higher, preferably equal two or higher, and the lone electron pair of the imine nitrogen atom and/or the pi-electrons of the imine double bond of at least one group B is conjugated with the conjugated system of delocalized electrons comprised in the structural moiety A, with the proviso that two or more of the substituents R 1 , R 2 , R 3 , R 4 may be connected to form a ring that may contain also unsaturation and, if any of the substituents R 1 , R 2 , R 3 , R 4 comprises two or more carbon atoms, up to one third of the overall count of the carbon atoms in the substituent or in any ring formed by two connected substituents can be replaced with heteroatoms independently selected from O, S, N and B as well as to an electrically semiconducting material and a compound for use in the electronic device.

Compounds for organic photovoltaic devices

本发明涉及如下的有机太阳能电池，该太阳能电池包含用作受体、电子传输材料和掺杂电子传输材料的新型吐昔醌（truxequinone）衍生物。

Imino compounds as protecting agents against ultraviolet radiations

Aromatic polyamine derivative

Aromatic polyamine derivatives of this invention are represented by following Formula (1): wherein Ring Z represents a monocyclic or polycyclic aromatic ring; R a , R b , R c , and R d are each a substituent bonded to Ring Z, where R a and R b are the same as or different from each other and each represent a protected or unprotected amino group, and R c and R d are the same as or different from each other and each represent a protected or unprotected amino group, a protected or unprotected hydroxy group, or a protected or unprotected mercapto group, and wherein at least one of R a , R b , R c , and R d represents an amino group protected by an alkylidene group.

Gadusol-containing sunscreen formulations

Embodiments of sunscreen formulations are disclosed herein. In one example, a sunscreen formulation includes a) a physical/inorganic sunscreen active ingredient at from about 5% to about 25% on a weight/weight (w/w) basis, wherein the active ingredient generates a first sun protection factor (“SPF”) value to a sunscreen formulation; b) gadusol; and c) a plurality of ingredients configured to deliver ingredients a) and b) in the sunscreen formulation, wherein the gadusol is present in the sunscreen formulation in an amount sufficient to generate a SPF booster effect in the sunscreen formulation.